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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PIN1 Gene

protein-coding   GIFtS: 73
GCID: GC19P009945

Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 1

(Previous name: protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting...)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 11 2     DOD2 5
Protein (Peptidyl-Prolyl Cis/Trans Isomerase) NIMA-Interacting 11 2     UBL52
Rotamase Pin12 3     Peptidyl-Prolyl Cis-Trans Isomerase NIMA-Interacting 12
PPIase Pin12 3     Peptidyl-Prolyl Cis-Trans Isomerase Pin13
EC 5.2.1.83 8     

External Ids:    HGNC: 89881   Entrez Gene: 53002   Ensembl: ENSG000001274457   OMIM: 6010525   UniProtKB: Q135263   
ORGUL members:         
NONCODE14:n411007 n410960      

Export aliases for PIN1 gene to outside databases

Previous GC identifers: GC19P010067 GC19P010168 GC19P009791 GC19P009807 GC19P009784 GC19P009806 GC19P009526


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PIN1 Gene:
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide
bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to
catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation
catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth,
genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell
development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of
Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this
gene.(provided by RefSeq, Jun 2011)

GeneCards Summary for PIN1 Gene: 
PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with PIN1 include adenoiditis, and frontotemporal dementia, and among its related super-pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Interferon Signaling. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and GTPase activating protein binding.

UniProtKB/Swiss-Prot: PIN1_HUMAN, Q13526
Function: Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its
mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline
bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate
multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required
for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML for
degradation in a phosphorylation-dependent manner

Gene Wiki entry for PIN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PIN1 gene promoter:
         Elk-1   Pax-5   AP-1   ATF-2   CBF-C   CBF-A   CBF-B   STAT3   c-Jun   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PIN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13

PIN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIN1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P009945:  view genomic region     (about GC identifiers)

Start:
9,945,883 bp from pter      End:
9,960,365 bp from pter
Size:
14,483 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for PIN1

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PIN1_HUMAN, Q13526 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1  
Size: 163 amino acids; 18243 Da
Subunit: Interacts with STIL (By similarity). Interacts with KIF20B. Interacts with NEK6. Interacts (via WW
domain) with PRKX. Interacts with BTK. Interacts (via PpiC domain) with DAPK1. Interacts with the phosphorylated
form of RAF1. Interacts (via WW domain) with ATCAY; upon NGF stimulation. Interacts with PML (isoform PML-4)
Subcellular location: Nucleus. Nucleus speckle. Cytoplasm. Note=Co-localizes with NEK6 in the nucleus. Mainly
localized in the nucleus but phosphorylation at Ser-71 by DAPK1 results in inhibition of its nuclear localization
6/49 PDB 3D structures from and Proteopedia for PIN1 (see all 49):
1F8A (3D)        1I6C (3D)        1I8G (3D)        1I8H (3D)        1NMV (3D)        1NMW (3D)    
Secondary accessions: A8K4V9 Q53X75

Explore the universe of human proteins at neXtProt for PIN1: NX_Q13526

Explore proteomics data for PIN1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Ser-71 by DAPK1 results in inhibition of its catalytic activity, nuclear localization, and its
    ability to induce centrosome amplification, chromosome instability and cell transformation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13526

  • 3 DME Specific Peptides for PIN1 (Q13526)
     SRRPSSW  QMQKPFE  KEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGD 

    PIN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PIN1 Protein Expression
    REFSEQ proteins: NP_006212.1  
    ENSEMBL proteins: 
     ENSP00000466656   ENSP00000247970   ENSP00000466962   ENSP00000467197   ENSP00000466780  
    Reactome Protein details: Q13526
    Human Recombinant Protein Products for PIN1: 
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    R&D Systems Recombinant & Natural Proteins for PIN1
    Enzo Life Sciences proteins for PIN1
    OriGene Purified Protein for PIN1
    OriGene Protein Over-expression Lysate for PIN1
    OriGene MassSpec for PIN1 
    OriGene Custom Protein Services for PIN1
    GenScript Custom Purified and Recombinant Proteins Services for PIN1
    Novus Biologicals PIN1 Proteins
    Novus Biologicals PIN1 Lysate
    Sino Biological Recombinant Protein for PIN1
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PIN1
    Cloud-Clone Corp. Proteins for PIN1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--
    GO:0016607nuclear speck IEA--
    GO:0030496midbody IDA19638580

    PIN1 for ontologies           About GeneDecksing



    PIN1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PIN1
    R&D Systems Antibodies for PIN1
    Cell Signaling Technology (CST) Antibodies for PIN1 
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    Novus Biologicals PIN1 Antibodies
    Abcam antibodies for PIN1
    Cloud-Clone Corp. Antibodies for PIN1 
    ThermoFisher Antibodies for PIN1
    LSBio Antibodies in human, mouse, rat for PIN1 

    Assay Products for PIN1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PIN1
    R&D Systems ELISAs for PIN1
    GenScript Custom Assay Services for PIN1
    Enzo Life Sciences assays for PIN1
    Cloud-Clone Corp. ELISAs for PIN1 
    Cloud-Clone Corp. CLIAs for PIN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR000297 PPIase_PpiC
     IPR023058 PPIase_PpiC_CS
     IPR001202 WW_dom

    Graphical View of Domain Structure for InterPro Entry Q13526

    ProtoNet protein and cluster: Q13526

    2 Blocks protein domains:
    IPB000297 PpiC-type peptidyl-prolyl cis-trans isomerase
    IPB002349 WW domain signature


    UniProtKB/Swiss-Prot: PIN1_HUMAN, Q13526
    Domain: The WW domain is required for the interaction with STIL and KIF20B
    Similarity: Contains 1 PpiC domain
    Similarity: Contains 1 WW domain


    PIN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIN1_HUMAN, Q13526
    Function: Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its
    mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline
    bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate
    multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required
    for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML for
    degradation in a phosphorylation-dependent manner
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)

         Genatlas biochemistry entry for PIN1:
    nuclear peptidyl-prolyl cis/trans isomerase,member of a family different from the cyclophilin and FK506 binding
    protein classes,homolog to Drosophila dodo,yeast ESS1,involved in the regulation of mitosis by modulating the
    NIMA pathway. Restoring the function of Alzheimer-associated phosphorylated tau protein (MAPT)

         Enzyme Number (IUBMB): EC 5.2.1.81 2

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IDA19122240
    GO:0005515protein binding IPI11470801
    GO:0016853isomerase activity ----
    GO:0031434mitogen-activated protein kinase kinase binding IPI--
    GO:0032794GTPase activating protein binding IPI--
         
    PIN1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PIN1:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pin1):
     cellular  endocrine/exocrine gland  growth/size  integument  nervous system 
     other  reproductive system  vision/eye 

    PIN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pin1tm1Tuc for PIN1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PIN1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PIN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PIN1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PIN1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIN1
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate PIN1:
    hsa-miR-140-5p hsa-miR-200c hsa-miR-429 hsa-miR-4318 hsa-miR-200b hsa-miR-892a
    SwitchGear 3'UTR luciferase reporter plasmidPIN1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: PIN1 (NM_006221)
    Sino Biological Human cDNA Clone for PIN1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIN1
    Sirion Biotech Customized lentivirus for stable overexpression of PIN1 
                         Customized lentivirus expression plasmids for stable overexpression of PIN1 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIN1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PIN1 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.52
    Negative regulators of RIG-I/MDA5 signaling0.49
    RIG-I-like receptor signaling pathway0.52
    2Interferon Signaling
    Interferon Signaling0.61
    Antiviral mechanism by IFN-stimulated genes0.42
    Cytokine Signaling in Immune system0.61
    ISG15 antiviral mechanism0.42
    3Immune System
    Immune System0.56
    Innate Immune System0.50
    4Wnt signaling pathway
    Wnt Signaling Pathway NetPath0.37
    5DNA Damage
    Cell Cycle / Checkpoint Control0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for PIN1
        Cell Cycle / Checkpoint Control

    3 BioSystems Pathways for PIN1
        Wnt Signaling Pathway NetPath
    p53 pathway
    C-MYC pathway


    5/8        Reactome Pathways for PIN1 (see all 8)
        Antiviral mechanism by IFN-stimulated genes
    Cytokine Signaling in Immune system
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    Interferon Signaling
    Negative regulators of RIG-I/MDA5 signaling


    1         Kegg Pathway  (Kegg details for PIN1):
        RIG-I-like receptor signaling pathway


    PIN1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/359 Interacting proteins for PIN1 (Q135261, 2, 3 ENSP000002479704) via UniProtKB, MINT, STRING, and/or I2D (see all 359)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADARB1P785632, 3, ENSP000003539204MINT-8298746 MINT-8299062 MINT-8299112 MINT-8298729 MINT-8299021 MINT-8299182 MINT-8299087 MINT-8298958 MINT-8299154 MINT-8299198 MINT-8299034 MINT-8298987 I2D: score=1 STRING: ENSP00000353920
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000413protein peptidyl-prolyl isomerization IDA19122240
    GO:0001934positive regulation of protein phosphorylation IGI19638580
    GO:0006457protein folding IEA--
    GO:0007049cell cycle IEA--
    GO:0007088regulation of mitosis TAS10391244

    PIN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PIN1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PIN1

    2 DrugBank Compounds for PIN1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3,6,9,12,15,18-HEXAOXAICOSANE-- --target--10592235
    Beta-(2-Naphthyl)-Alanine-- --target--10592235

    10/19 Novoseek inferred chemical compound relationships for PIN1 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    juglone 87.5 24 18539601 (3), 11160900 (1), 15171797 (1), 17626162 (1) (see all 12)
    slyd 80.7 4 19356587 (3), 17397867 (2), 19920179 (1)
    proline 74.4 20 9395400 (3), 8718848 (1), 15171797 (1), 15474361 (1) (see all 17)
    phosphoserine 69.3 6 11090625 (2), 11723108 (2), 20110589 (1), 17892493 (1)
    miha 64.2 2 16841372 (1), 17383430 (1)
    threonine 57.7 14 17626162 (2), 15701524 (2), 15171797 (1), 19592546 (1) (see all 11)
    tacrolimus 53.5 8 7642551 (1), 16302169 (1), 19136015 (1), 8521476 (1) (see all 7)
    serine 50.9 16 17626162 (2), 9395400 (2), 15171797 (1), 19592546 (1) (see all 12)
    rapamycin 43.8 7 7642551 (1), 8635249 (1), 9124414 (1), 17518432 (1) (see all 5)
    cyclosporin a 40.1 5 7673124 (2), 15870468 (1), 9144255 (1)

    Search CenterWatch for drugs/clinical trials and news about PIN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PIN1 gene: 
    NM_006221.3  

    Unigene Cluster for PIN1:

    Peptidylprolyl cis/trans isomerase, NIMA-interacting 1
    Hs.465849  [show with all ESTs]
    Unigene Representative Sequence: BC031971
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592184 ENST00000587625 ENST00000247970(uc002mmk.2 uc021uor.1 uc002mml.2)
    ENST00000586025 ENST00000590540 ENST00000588695 ENST00000586352 ENST00000585442
    ENST00000589058 ENST00000380889(uc002mmn.2) ENST00000591777

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    Additional mRNA sequence: 

    AF086512.1 AK291074.1 BC002899.1 BC031971.1 BT019331.1 CR407654.1 NR_038422.2 NR_038830.1 
    U49070.1 

    14 DOTS entries:

    DT.447950  DT.100796246  DT.100796249  DT.95151060  DT.102831158  DT.40124963  DT.97767920  DT.91693634 
    DT.95151061  DT.100796251  DT.121451437  DT.40237978  DT.91743544  DT.97820239 

    24/283 AceView cDNA sequences (see all 283):

    AX747830 AI880008 BU683491 BU753564 AA994658 AI815708 BC002899 CR407654 
    CA422674 CB528395 BM128520 BE392505 CD365653 BI829812 BM711466 AA566019 
    CF529035 BI871560 BU557229 R88944 BQ678260 BM700455 BQ068942 BQ933579 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PIN1 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10a · 10b · 10c
    SP1:                    -     -           -     -                 -           -     -     -     -     -     -               
    SP2:                    -     -                                   -                                                         
    SP3:                                      -     -                 -           -     -     -     -     -     -               
    SP4:                    -     -     -     -     -                 -           -     -     -     -     -     -               
    SP5:                    -     -     -           -                 -                                                         


    ECgene alternative splicing isoforms for PIN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PIN1 expression in normal human tissues (normalized intensities)      PIN1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCCTCTGA
    PIN1 Expression
    About this image


    PIN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             orbitofrontal cortex   
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Spermatogonial Stem Cells Seminiferous Tubules
     
     Gonad
             Spermatogonial Stem Cells Seminiferous Tubules

    See PIN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PIN1

    SOURCE GeneReport for Unigene cluster: Hs.465849

    UniProtKB/Swiss-Prot: PIN1_HUMAN, Q13526
    Tissue specificity: The phosphorylated form at Ser-71 is expressed in normal breast tissue cells but not in breast
    cancer cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including PIN1: 
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              Liver Cancer in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PIN1 gene from 9/28 species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pin11 , 5 protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting more1, 5 88.96(n)1
    96.32(a)1
      9 (7.60 cM)5
    239881  NM_023371.31  NP_075860.11 
     206521305 
    chicken
    (Gallus gallus)
    Aves LOC1008591531 peptidyl-prolyl cis-trans isomerase NIMA-interacting more 85.39(n)
    94.52(a)
      100859153  XM_003643565.1  XP_003643613.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia AF239760.12   -- 81.62(n)    AF239760.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc732062 hypothetical protein MGC73206 82.52(n)   393721  BC059553.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dod1 , 3 peptidyl-prolyl cis-trans isomerase3
    dodo1
    55(a)3
    61.08(n)1
    57.76(a)1
      1 19F53
    331111  NM_078704.31  NP_523428.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y110A2AL.131 , 3 Protein Y110A2AL.131 54(a)3
    58.01(n)1
    59.74(a)1
      II(2886386-2888999)3
    1909411  NM_061992.11  NP_494393.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ESS1(YJR017C)4
    ESS11
    Peptidylprolyl-cis/trans-isomerase (PPIase) specific more4
    Ess1p1
    49.48(n)1
    47.2(a)1
      10(467033-466521)4
    8534751, 4  NP_012551.21, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PIN1AT1 Peptidyl-prolyl cis-trans isomerase Pin1 54.13(n)
    53.21(a)
      816316  NM_127360.3  NP_179395.1 
    rice
    (Oryza sativa)
    Liliopsida Os.376802 Transcribed sequence with strong similarity to protein more 78.85(n)    AU095312.1 


    ENSEMBL Gene Tree for PIN1 (if available)
    TreeFam Gene Tree for PIN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PIN1 gene
    1 SIMAP similar gene for PIN1 using alignment to 6 protein entries:     PIN1_HUMAN (see all proteins):
    PIN1P1

    PIN1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PIN1
    PGOHUM00000244752


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/271 SNPs in PIN1 are shown (see all 271)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs665774851,2
    C,F--9880454(+) AATTAT/CTTTTG 3 -- us2k15Minor allele frequency- C:0.26WA CSA NA 244
    rs1410490661,2
    --9880490(+) CCAGGA/CTGGTC 3 -- us2k10--------
    rs1857914451,2
    --9880592(+) TAATTC/TTTTTG 3 -- us2k10--------
    rs1917307831,2
    --9880598(+) TTTTGA/GTGGGG 3 -- us2k10--------
    rs1913748291,2
    --9884378(+) CTTGGC/TGCACT 3 -- int10--------
    rs1838281391,2
    --9884417(+) TTCTCC/TTGCCT 3 -- int10--------
    rs2016732851,2
    --9884613(+) GCCTG-/TTGTTT
            
    TTGTT
    3 -- int10--------
    rs1895753371,2
    --9884643(+) AGAGTC/TTCACT 3 -- int10--------
    rs1506856121,2
    --9884651(+) ACTCTA/GTCGCT 3 -- int10--------
    rs1391111501,2
    --9884775(+) ACGCCC/TGGCTA 3 -- int10--------

    HapMap Linkage Disequilibrium report for PIN1 (9945883 - 9960365 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PIN1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv520683CNV Loss19592680
    esv33490CNV Loss17666407


    Human Gene Mutation Database (HGMD): PIN1
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for PIN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601052    OMIM disorders: --

    20/45 diseases for PIN1 (see all 45):    About MalaCards
    adenoiditis    frontotemporal dementia    adenoid cystic carcinoma    familial adenomatous polyposis
    tauopathy    alzheimer's disease    spinal cord injury    human t-cell leukemia virus type 1
    dementia    cervical cancer    papilloma    oral squamous cell carcinoma
    t-cell leukemia    squamous cell carcinoma    esophageal squamous cell carcinoma    cervicitis
    hepatocellular carcinoma    colorectal cancer    acute myeloid leukemia    lung cancer


    PIN1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/18 Novoseek inferred disease relationships for PIN1 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 52.1 25 18007120 (3), 17361031 (2), 17965833 (2), 19909517 (2) (see all 17)
    frontotemporal dementia 45.6 3 20110589 (1), 19909517 (1), 16480979 (1)
    cancer 40.5 64 15111319 (5), 17965833 (2), 16449657 (2), 17275947 (2) (see all 36)
    neurofibrillary tangles 39.2 2 11212339 (1), 12410395 (1)
    neurodegeneration 30.2 11 16480979 (3), 20110589 (2), 16095818 (2), 17626162 (1) (see all 6)
    breast cancer 28.7 41 19077306 (7), 11533658 (2), 15257284 (2), 11432833 (2) (see all 22)
    tumors 24.8 56 17275947 (4), 15111319 (3), 11432833 (3), 17383430 (3) (see all 26)
    carcinoma squamous cell 18.1 15 12792768 (2), 12579289 (2), 19288014 (2), 19502098 (2) (see all 7)
    neurodegenerative diseases 17.3 8 20110589 (2), 18635547 (2), 19940183 (1), 16480979 (1)
    carcinoma adenoid cystic 15.1 7 16865250 (2), 17129455 (2)

    Genetic Association Database (GAD): PIN1
    Human Genome Epidemiology (HuGE) Navigator: PIN1 (16 documents)

    Export disorders for PIN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PIN1 gene, integrated from 9 sources (see all 345):
    (articles sorted by number of sources associating them with PIN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human peptidyl-prolyl isomerase essential for regulation of mitosis. (PubMed id 8606777)1, 2, 3 Lu K.P.... Hunter T. (1996)
    2. PIN1 gene variants in Alzheimer's disease. (PubMed id 19909517)1, 4, 9 Maruszak A....Zekanowski C. (2009)
    3. A novel functional variant (-842G>C) in the PIN1 p romoter contributes to decreased risk of squamous cell carcinoma of the head an d neck by diminishing the promoter activity. (PubMed id 19625347)1, 4, 9 Lu J....Wei Q. (2009)
    4. Association studies between common variants in prolyl isomerase Pin1 and the risk for late-onset Alzheimer's disease. (PubMed id 17482359)1, 4, 9 Nowotny P....Goate A. (2007)
    5. Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients. (PubMed id 16476580)1, 2, 9 Chen J....Yu L. (2006)
    6. DNA sequence variations in the prolyl isomerase Pin1 gene and Alzheimer's disease. (PubMed id 16095818)1, 4, 9 Poli M....Finazzi D. (2005)
    7. PIN-1 promoter polymorphisms in mild cognitive impairment and susceptibility to Alzheimer's disease: a preliminary report. (PubMed id 18007120)1, 4, 9 Arosio B....Vergani C. (2007)
    8. Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function. (PubMed id 21497122)1, 2 Lee T.H....Lu K.P. (2011)
    9. Mitogen-activated protein kinase extracellular signal- regulated kinase 2 phosphorylates and promotes Pin1 protein-dependent promyelocy tic leukemia protein turnover. (PubMed id 22033920)1, 2 Lim J.H....Kao H.Y. (2011)
    10. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5300 HGNC: 8988 AceView: PIN1 Ensembl:ENSG00000127445 euGenes: HUgn5300
    ECgene: PIN1 Kegg: 5300 H-InvDB: PIN1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PIN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PIN1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PIN1 gene:
    Search GeneIP for patents involving PIN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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