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Aliases for PIN1 Gene

Aliases for PIN1 Gene

  • Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 1 2 3 5
  • Protein (Peptidyl-Prolyl Cis/Trans Isomerase) NIMA-Interacting 1 2 3
  • Rotamase Pin1 3 4
  • PPIase Pin1 3 4
  • EC 5.2.1.8 4 63
  • Peptidyl-Prolyl Cis-Trans Isomerase Pin1 4
  • UBL5 3
  • DOD 3

External Ids for PIN1 Gene

Previous GeneCards Identifiers for PIN1 Gene

  • GC19P010067
  • GC19P010168
  • GC19P009791
  • GC19P009807
  • GC19P009784
  • GC19P009806
  • GC19P009945
  • GC19P009526

Summaries for PIN1 Gene

Entrez Gene Summary for PIN1 Gene

  • Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]

GeneCards Summary for PIN1 Gene

PIN1 (Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 1) is a Protein Coding gene. Diseases associated with PIN1 include meibomian cyst and erythema infectiosum. Among its related pathways are Gene Expression and Immune System. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and mitogen-activated protein kinase kinase binding.

UniProtKB/Swiss-Prot for PIN1 Gene

  • Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs in a subset of proteins, resulting in conformational changes in the proteins (PubMed:21497122, PubMed:22033920). Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923).

Gene Wiki entry for PIN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIN1 Gene

Genomics for PIN1 Gene

Regulatory Elements for PIN1 Gene

Promoters for PIN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PIN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PIN1 Gene

Chromosome:
19
Start:
9,835,207 bp from pter
End:
9,849,689 bp from pter
Size:
14,483 bases
Orientation:
Plus strand

Genomic View for PIN1 Gene

Genes around PIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIN1 Gene

Proteins for PIN1 Gene

  • Protein details for PIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13526-PIN1_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
    Protein Accession:
    Q13526
    Secondary Accessions:
    • A8K4V9
    • Q53X75

    Protein attributes for PIN1 Gene

    Size:
    163 amino acids
    Molecular mass:
    18243 Da
    Quaternary structure:
    • Interacts with STIL. Interacts with KIF20B. Interacts with NEK6. Interacts (via WW domain) with PRKX. Interacts with BTK. Interacts (via PpiC domain) with DAPK1. Interacts with the phosphorylated form of RAF1. Interacts (via WW domain) with ATCAY; upon NGF stimulation. Interacts with PML (isoform PML-4) and BCL-6. Interacts with FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation (PubMed:22608923).

    Three dimensional structures from OCA and Proteopedia for PIN1 Gene

neXtProt entry for PIN1 Gene

Proteomics data for PIN1 Gene at MOPED

Selected DME Specific Peptides for PIN1 Gene

Post-translational modifications for PIN1 Gene

  • Phosphorylation at Ser-71 by DAPK1 results in inhibition of its catalytic activity, nuclear localization, and its ability to induce centrosome amplification, chromosome instability and cell transformation.
  • Ubiquitination at Lys 82, Lys 97, Lys 117, and Lys 132
  • Modification sites at PhosphoSitePlus

Other Protein References for PIN1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PIN1 (PIN1)

Domains & Families for PIN1 Gene

Gene Families for PIN1 Gene

Suggested Antigen Peptide Sequences for PIN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13526

UniProtKB/Swiss-Prot:

PIN1_HUMAN :
  • The WW domain is required for the interaction with STIL and KIF20B.
Domain:
  • The WW domain is required for the interaction with STIL and KIF20B.
  • Contains 1 PpiC domain.
  • Contains 1 WW domain.
genes like me logo Genes that share domains with PIN1: view

Function for PIN1 Gene

Molecular function for PIN1 Gene

GENATLAS Biochemistry:
nuclear peptidyl-prolyl cis/trans isomerase,member of a family different from the cyclophilin and FK506 binding protein classes,homolog to Drosophila dodo,yeast ESS1,involved in the regulation of mitosis by modulating the NIMA pathway. Restoring the function of Alzheimer-associated phosphorylated tau protein (MAPT)
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs in a subset of proteins, resulting in conformational changes in the proteins (PubMed:21497122, PubMed:22033920). Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923).

Enzyme Numbers (IUBMB) for PIN1 Gene

Gene Ontology (GO) - Molecular Function for PIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031434 mitogen-activated protein kinase kinase binding IPI 20179103
GO:0050816 phosphothreonine binding IPI 10037602
genes like me logo Genes that share ontologies with PIN1: view
genes like me logo Genes that share phenotypes with PIN1: view

Animal Models for PIN1 Gene

MGI Knock Outs for PIN1:

Animal Model Products

  • Taconic Biosciences Mouse Models for PIN1

miRNA for PIN1 Gene

miRTarBase miRNAs that target PIN1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIN1 Gene

Localization for PIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIN1 Gene

Nucleus. Nucleus speckle. Cytoplasm. Note=Colocalizes with NEK6 in the nucleus (PubMed:16476580). Mainly localized in the nucleus but phosphorylation at Ser-71 by DAPK1 results in inhibition of its nuclear localization (PubMed:21497122). {ECO:0000269 PubMed:16476580}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIN1 Gene COMPARTMENTS Subcellular localization image for PIN1 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 3
cytoskeleton 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with PIN1: view

Pathways & Interactions for PIN1 Gene

genes like me logo Genes that share pathways with PIN1: view

SIGNOR curated interactions for PIN1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization TAS 11533658
GO:0007088 regulation of mitotic nuclear division TAS 10391244
GO:0030182 neuron differentiation ISS --
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA 19122240
GO:0032465 regulation of cytokinesis IMP 19638580
genes like me logo Genes that share ontologies with PIN1: view

Drugs & Compounds for PIN1 Gene

(13) Drugs for PIN1 Gene - From: Novoseek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
3,6,9,12,15,18-HEXAOXAICOSANE Experimental Pharma Target 0
Beta-(2-Naphthyl)-Alanine Experimental Pharma Target 0

(8) Additional Compounds for PIN1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PIN1: view

Transcripts for PIN1 Gene

Unigene Clusters for PIN1 Gene

Peptidylprolyl cis/trans isomerase, NIMA-interacting 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIN1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10a · 10b · 10c
SP1: - - - - - - - - - - -
SP2: - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - -
SP8: - - - - -
SP9:
SP10: -

Relevant External Links for PIN1 Gene

GeneLoc Exon Structure for
PIN1
ECgene alternative splicing isoforms for
PIN1

Expression for PIN1 Gene

mRNA expression in normal human tissues for PIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIN1 Gene



SOURCE GeneReport for Unigene cluster for PIN1 Gene Hs.465849

mRNA Expression by UniProt/SwissProt for PIN1 Gene

Q13526-PIN1_HUMAN
Tissue specificity: The phosphorylated form at Ser-71 is expressed in normal breast tissue cells but not in breast cancer cells.
genes like me logo Genes that share expression patterns with PIN1: view

Protein tissue co-expression partners for PIN1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for PIN1 Gene

Orthologs for PIN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PIN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PIN1 35
  • 93.66 (n)
  • 98.16 (a)
PIN1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIN1 35
  • 93.46 (n)
  • 98.77 (a)
PIN1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pin1 35
  • 88.96 (n)
  • 96.32 (a)
Pin1 16
Pin1 36
  • 94 (a)
OneToMany
Pin1rt1 36
  • 93 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia PIN1 35
  • 99.18 (n)
  • 100 (a)
PIN1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pin1 35
  • 89.16 (n)
  • 96.93 (a)
oppossum
(Monodelphis domestica)
Mammalia PIN1 36
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIN1 35
  • 83.33 (n)
  • 92.11 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pin1 35
  • 80.29 (n)
  • 89.31 (a)
zebrafish
(Danio rerio)
Actinopterygii pin1 35
  • 76.37 (n)
  • 81.01 (a)
zgc73206 35
pin1 36
  • 77 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4858 35
fruit fly
(Drosophila melanogaster)
Insecta dod 37
  • 55 (a)
dod 35
  • 61.08 (n)
  • 57.76 (a)
dod 36
  • 55 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004321 35
  • 57.14 (n)
  • 58.39 (a)
worm
(Caenorhabditis elegans)
Secernentea Y110A2AL.13 37
  • 54 (a)
Y110A2AL.13 35
  • 57.48 (n)
  • 58.97 (a)
pinn-1 36
  • 58 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL120W 35
  • 53.42 (n)
  • 46.58 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E16567g 35
  • 47.96 (n)
  • 52.26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ESS1 35
  • 49.18 (n)
  • 46.91 (a)
ESS1 36
  • 44 (a)
OneToOne
ESS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PIN1AT 35
  • 54.13 (n)
  • 53.21 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7834 35
rice
(Oryza sativa)
Liliopsida Os.37680 35
Os04g0663800 35
  • 59.9 (n)
  • 60.87 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3441 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08554 35
  • 54.58 (n)
  • 56.87 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pin1 35
  • 49.03 (n)
  • 52.26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
OneToOne
Species with no ortholog for PIN1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIN1 Gene

ENSEMBL:
Gene Tree for PIN1 (if available)
TreeFam:
Gene Tree for PIN1 (if available)

Paralogs for PIN1 Gene

(1) SIMAP similar genes for PIN1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for PIN1 Gene

genes like me logo Genes that share paralogs with PIN1: view

No data available for Paralogs for PIN1 Gene

Variants for PIN1 Gene

Sequence variations from dbSNP and Humsavar for PIN1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs889162 -- 9,841,240(-) AACTC(A/G)GCTTC intron-variant
rs752813 -- 9,848,420(-) CTTGG(C/T)GGGCC intron-variant
rs2010457 -- 9,848,202(-) CCTCC(C/T)GGCCT intron-variant
rs1862472 -- 9,847,181(-) TGTGT(G/T)CACGT intron-variant
rs2287838 -- 9,848,338(-) AAGTG(C/T)TGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIN1 Gene

Variant ID Type Subtype PubMed ID
nsv520683 CNV Loss 19592680
esv33490 CNV Loss 17666407

Variation tolerance for PIN1 Gene

Residual Variation Intolerance Score: 46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIN1 Gene

HapMap Linkage Disequilibrium report
PIN1
Human Gene Mutation Database (HGMD)
PIN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIN1 Gene

Disorders for PIN1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for PIN1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
meibomian cyst
  • chalazion
erythema infectiosum
  • fifth disease
viral exanthem
alzheimer disease
  • alzheimer disease, late-onset
dementia, frontotemporal
  • dementia, frontotemporal, with or without parkinsonism
- elite association - COSMIC cancer census association via MalaCards
Search PIN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PIN1

Genetic Association Database (GAD)
PIN1
Human Genome Epidemiology (HuGE) Navigator
PIN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIN1
genes like me logo Genes that share disorders with PIN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIN1 Gene

Publications for PIN1 Gene

  1. A human peptidyl-prolyl isomerase essential for regulation of mitosis. (PMID: 8606777) Lu K.P. … Hunter T. (Nature 1996) 2 3 4 67
  2. Pin1 promotes transforming growth factor-beta-induced migration and invasion. (PMID: 19920136) Matsuura I. … Liu F. (J. Biol. Chem. 2010) 3 23
  3. Pin1 expression contributes to lung cancer: Prognosis and carcinogenesis. (PMID: 20009523) Tan X. … He J. (Cancer Biol. Ther. 2010) 3 23
  4. Prolyl-peptidyl isomerase, Pin1, phosphorylation is compromised in association with the expression of the HFE polymorphic allele, H63D. (PMID: 20060900) Hall E.C. … Connor J.R. (Biochim. Biophys. Acta 2010) 3 23
  5. Phosphorylation-specific peptidyl-prolyl isomerization of neuronal cytoskeletal proteins by Pin1: implications for therapeutics in neurodegeneration. (PMID: 20110589) Rudrabhatla P. … Pant H.C. (J. Alzheimers Dis. 2010) 3 23

Products for PIN1 Gene

Sources for PIN1 Gene

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