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PIN1 Gene

protein-coding   GIFtS: 74
GCID: GC19P009945

Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 1

(Previous name: protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting...)
  See PIN1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 11 2     DOD2 5
Protein (Peptidyl-Prolyl Cis/Trans Isomerase) NIMA-Interacting 11 2     UBL52
Rotamase Pin12 3     Peptidyl-Prolyl Cis-Trans Isomerase NIMA-Interacting 12
PPIase Pin12 3     Peptidyl-Prolyl Cis-Trans Isomerase Pin13
EC 5.2.1.83 8     

External Ids:    HGNC: 89881   Entrez Gene: 53002   Ensembl: ENSG000001274457   OMIM: 6010525   UniProtKB: Q135263   
ORGUL members:         

Export aliases for PIN1 gene to outside databases

Previous GC identifers: GC19P010067 GC19P010168 GC19P009791 GC19P009807 GC19P009784 GC19P009806 GC19P009526


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PIN1 Gene:
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide
bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to
catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation
catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth,
genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell
development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of
Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this
gene.(provided by RefSeq, Jun 2011)

GeneCards Summary for PIN1 Gene:
PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1) is a protein-coding gene. Diseases associated with PIN1 include adenoid cystic carcinoma, and alzheimer's disease. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and GTPase activating protein binding.

UniProtKB/Swiss-Prot: PIN1_HUMAN, Q13526
Function: Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its
mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline
bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate
multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required
for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML and
BCL6 for degradation in a phosphorylation-dependent manner

Gene Wiki entry for PIN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the PIN1 gene promoter:
         Elk-1   Pax-5   AP-1   ATF-2   CBF-C   CBF-A   CBF-B   STAT3   c-Jun   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIN1 promoter sequence
   Search Chromatin IP Primers for PIN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13

PIN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIN1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P009945:  view genomic region     (about GC identifiers)

Start:
9,945,883 bp from pter      End:
9,960,365 bp from pter
Size:
14,483 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for PIN1

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PIN1_HUMAN, Q13526 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1  
Size: 163 amino acids; 18243 Da
Subunit: Interacts with STIL. Interacts with KIF20B. Interacts with NEK6. Interacts (via WW domain) with PRKX.
Interacts with BTK. Interacts (via PpiC domain) with DAPK1. Interacts with the phosphorylated form of RAF1.
Interacts (via WW domain) with ATCAY; upon NGF stimulation. Interacts with PML (isoform PML-4) and BCL-6
Selected PDB 3D structures from and Proteopedia for PIN1 (see all 55):
1F8A (3D)        1I6C (3D)        1I8G (3D)        1I8H (3D)        1NMV (3D)        1NMW (3D)    
Secondary accessions: A8K4V9 Q53X75

Explore the universe of human proteins at neXtProt for PIN1: NX_Q13526

Explore proteomics data for PIN1 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-71 by DAPK1 results in inhibition of its catalytic activity, nuclear localization, and its
    ability to induce centrosome amplification, chromosome instability and cell transformation1
  • Ubiquitination2 at Lys13, Lys82, Lys97, Lys117, Lys132
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for PIN1 (Q13526)
     SRRPSSW  QMQKPFE  KEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGD 


    See PIN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006212.1  
    ENSEMBL proteins: 
     ENSP00000466656   ENSP00000247970   ENSP00000466962   ENSP00000467197   ENSP00000466780  
    Reactome Protein details: Q13526

    PIN1 Human Recombinant Protein Products:

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    Enzo Life Sciences proteins for PIN1
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    OriGene Protein Over-expression Lysate for PIN1
    OriGene MassSpec for PIN1
    OriGene Custom Protein Services for PIN1
    GenScript Custom Purified and Recombinant Proteins Services for PIN1
    Novus Biologicals PIN1 Proteins
    Novus Biologicals PIN1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PIN1
    Cloud-Clone Corp. Proteins for PIN1

     
    Search eBioscience for Proteins for PIN1 

     
    antibodies-online proteins for PIN1 (16 products) 

     
    antibodies-online peptides for PIN1

    PIN1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PIN1
    R&D Systems Antibodies for PIN1
    Cell Signaling Technology (CST) Antibodies for PIN1 
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    Novus Biologicals PIN1 Antibodies
    Abcam antibodies for PIN1
    Cloud-Clone Corp. Antibodies for PIN1
    ThermoFisher Antibodies for PIN1
    antibodies-online antibodies for PIN1 (132 products) 

    PIN1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for PIN1
    Cloud-Clone Corp. CLIAs for PIN1
    Search eBioscience for ELISAs for PIN1 
    antibodies-online kits for PIN1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000297 PPIase_PpiC
     IPR023058 PPIase_PpiC_CS
     IPR001202 WW_dom

    Graphical View of Domain Structure for InterPro Entry Q13526

    ProtoNet protein and cluster: Q13526

    2 Blocks protein domains:
    IPB000297 PpiC-type peptidyl-prolyl cis-trans isomerase
    IPB002349 WW domain signature


    UniProtKB/Swiss-Prot: PIN1_HUMAN, Q13526
    Domain: The WW domain is required for the interaction with STIL and KIF20B
    Similarity: Contains 1 PpiC domain
    Similarity: Contains 1 WW domain


    Find genes that share domains with PIN1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIN1_HUMAN, Q13526
    Function: Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its
    mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline
    bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate
    multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required
    for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML and
    BCL6 for degradation in a phosphorylation-dependent manner
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)

         Genatlas biochemistry entry for PIN1:
    nuclear peptidyl-prolyl cis/trans isomerase,member of a family different from the cyclophilin and FK506 binding
    protein classes,homolog to Drosophila dodo,yeast ESS1,involved in the regulation of mitosis by modulating the
    NIMA pathway. Restoring the function of Alzheimer-associated phosphorylated tau protein (MAPT)

         Enzyme Number (IUBMB): EC 5.2.1.81 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IDA19122240
    GO:0005515protein binding IPI11470801
    GO:0016853isomerase activity ----
    GO:0031434mitogen-activated protein kinase kinase binding IPI--
    GO:0032794GTPase activating protein binding IPI--
         
    Find genes that share ontologies with PIN1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for PIN1:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pin1):
     cellular  endocrine/exocrine gland  growth/size/body  integument  nervous system 
     other  reproductive system  vision/eye 

    Find genes that share phenotypes with PIN1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pin1tm1Tuc for PIN1

       genOway: Develop your customized and physiologically relevant rodent model for PIN1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PIN1:
    hsa-mir-484 (MIRT042314), hsa-mir-324-5p (MIRT043127)

    Block miRNA regulation of human, mouse, rat PIN1 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate PIN1:
    hsa-miR-140-5p hsa-miR-200c hsa-miR-429 hsa-miR-4318 hsa-miR-200b hsa-miR-892a
    SwitchGear 3'UTR luciferase reporter plasmidPIN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PIN1
    Predesigned siRNA for gene silencing in human, mouse, rat PIN1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PIN1

    Clone
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    OriGene clones in human, mouse for PIN1 (see all 8)
    OriGene ORF clones in mouse, rat for PIN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PIN1 (NM_006221)
    Sino Biological Human cDNA Clone for PIN1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIN1
    Addgene plasmids for PIN1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PIN1
    Browse ESI BIO Cell Lines and PureStem Progenitors for PIN1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PIN1_HUMAN, Q13526: Nucleus. Nucleus speckle. Cytoplasm. Note=Colocalizes with NEK6 in the nucleus. Mainly
    localized in the nucleus but phosphorylation at Ser-71 by DAPK1 results in inhibition of its nuclear localization
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--
    GO:0016607nuclear speck IEA--
    GO:0030496midbody IDA19638580

    Find genes that share ontologies with PIN1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PIN1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    Negative regulators of RIG-I/MDA5 signaling0.42
    RIG-I-like receptor signaling pathway0.47
    2Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    3Wnt signaling pathway (KEGG)
    Wnt Signaling Pathway NetPath0.37
    4Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    5p53 pathway
    p53 pathway


    Find genes that share SuperPaths with PIN1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for PIN1
        Cell Cycle / Checkpoint Control

    3 BioSystems Pathways for PIN1
        Wnt Signaling Pathway NetPath
    p53 pathway
    C-MYC pathway


    2 Reactome Pathways for PIN1
        Negative regulators of RIG-I/MDA5 signaling
    ISG15 antiviral mechanism


    1 Kegg Pathway  (Kegg details for PIN1):
        RIG-I-like receptor signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PIN1: 
              Antiviral Response in human mouse rat
              Liver Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PIN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PIN1 (Q135261, 2, 3 ENSP000002479704) via UniProtKB, MINT, STRING, and/or I2D (see all 475)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADARB1P785631, 2, 3, ENSP000003539204EBI-714158,EBI-2967304 MINT-8298746 MINT-8299062 MINT-8299112 MINT-8298729 MINT-8299021 MINT-8299182 MINT-8299087 MINT-8298958 MINT-8299154 MINT-8299198 MINT-8299034 MINT-8298987 I2D: score=1 STRING: ENSP00000353920
    HIST1H4HP628053, ENSP000002893524I2D: score=1 STRING: ENSP00000289352
    HIST1H4FP628053, ENSP000003669744I2D: score=1 STRING: ENSP00000366974
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000413protein peptidyl-prolyl isomerization IDA19122240
    GO:0001934positive regulation of protein phosphorylation IGI19638580
    GO:0006457protein folding IEA--
    GO:0007049cell cycle IEA--
    GO:0007088regulation of mitosis TAS10391244

    Find genes that share ontologies with PIN1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PIN1

    2 DrugBank Compounds for PIN1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3,6,9,12,15,18-HEXAOXAICOSANE-- --target--10592235
    Beta-(2-Naphthyl)-Alanine-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for PIN1 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    juglone 87.5 24 18539601 (3), 11160900 (1), 15171797 (1), 17626162 (1) (see all 12)
    slyd 80.7 4 19356587 (3), 17397867 (2), 19920179 (1)
    proline 74.4 20 9395400 (3), 8718848 (1), 15171797 (1), 15474361 (1) (see all 17)
    phosphoserine 69.3 6 11090625 (2), 11723108 (2), 20110589 (1), 17892493 (1)
    miha 64.2 2 16841372 (1), 17383430 (1)
    threonine 57.7 14 17626162 (2), 15701524 (2), 15171797 (1), 19592546 (1) (see all 11)
    tacrolimus 53.5 8 7642551 (1), 16302169 (1), 19136015 (1), 8521476 (1) (see all 7)
    serine 50.9 16 17626162 (2), 9395400 (2), 15171797 (1), 19592546 (1) (see all 12)
    rapamycin 43.8 7 7642551 (1), 8635249 (1), 9124414 (1), 17518432 (1) (see all 5)
    cyclosporin a 40.1 5 7673124 (2), 15870468 (1), 9144255 (1)



    Find genes that share compounds with PIN1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PIN1 gene: 
    NM_006221.3  

    Unigene Cluster for PIN1:

    Peptidylprolyl cis/trans isomerase, NIMA-interacting 1
    Hs.465849  [show with all ESTs]
    Unigene Representative Sequence: BC031971
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592184 ENST00000587625 ENST00000247970(uc002mmk.2 uc021uor.1 uc002mml.2)
    ENST00000586025 ENST00000590540 ENST00000588695 ENST00000586352 ENST00000585442
    ENST00000589058 ENST00000380889(uc002mmn.2) ENST00000591777
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate PIN1:
    hsa-miR-140-5p hsa-miR-200c hsa-miR-429 hsa-miR-4318 hsa-miR-200b hsa-miR-892a
    SwitchGear 3'UTR luciferase reporter plasmidPIN1 3' UTR sequence
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PIN1
      QuantiTect SYBR Green Assays in human, mouse, rat PIN1
      QuantiFast Probe-based Assays in human, mouse, rat PIN1

    Additional mRNA sequence: 

    AF086512.1 AK291074.1 BC002899.1 BC031971.1 BT019331.1 CR407654.1 NR_038422.2 NR_038830.1 
    U49070.1 

    14 DOTS entries:

    DT.447950  DT.100796246  DT.100796249  DT.95151060  DT.102831158  DT.40124963  DT.97767920  DT.91693634 
    DT.95151061  DT.100796251  DT.121451437  DT.40237978  DT.91743544  DT.97820239 

    Selected AceView cDNA sequences (see all 283):

    CR407654 AI880008 AI268158 BF436199 BE617305 AI199634 R88944 AA744132 
    CF529035 BE797127 BU170813 BU557229 AA864841 BQ670394 AV726587 BM128520 
    CD367366 CD106920 AX747830 CR622196 BX463403 BU753564 CF528778 AA566019 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PIN1 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10a · 10b · 10c
    SP1:                    -     -           -     -                 -           -     -     -     -     -     -               
    SP2:                    -     -                                   -                                                         
    SP3:                                      -     -                 -           -     -     -     -     -     -               
    SP4:                    -     -     -     -     -                 -           -     -     -     -     -     -               
    SP5:                    -     -     -           -                 -                                                         


    ECgene alternative splicing isoforms for PIN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PIN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCCTCTGA
    PIN1 Expression
    About this image


    PIN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Spermatogonial Stem Cells Seminiferous Tubules
     
     Gonad
             Spermatogonial Stem Cells Seminiferous Tubules
     
     Brain (Nervous System)
             Cerebral Cortex
    PIN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.465849

    UniProtKB/Swiss-Prot: PIN1_HUMAN, Q13526
    Tissue specificity: The phosphorylated form at Ser-71 is expressed in normal breast tissue cells but not in breast
    cancer cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PIN1: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PIN1 gene from Selected species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pin11 , 5 protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting more1, 5 88.96(n)1
    96.32(a)1
      9 (7.60 cM)5
    239881  NM_023371.31  NP_075860.11 
     206521305 
    chicken
    (Gallus gallus)
    Aves PIN11 peptidylprolyl cis/trans isomerase, NIMA-interacting more 83.33(n)
    92.11(a)
      100859153  XM_003643565.2  XP_003643613.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia AF239760.12   -- 81.62(n)    AF239760.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc732062 hypothetical protein MGC73206 82.52(n)   393721  BC059553.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dod1 , 3 peptidyl-prolyl cis-trans isomerase3
    dodo1
    55(a)3
    61.08(n)1
    57.76(a)1
      1 19F53
    331111  NM_078704.31  NP_523428.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y110A2AL.131 , 3 Y110A2AL.131 54(a)3
    57.48(n)1
    58.97(a)1
      II(2886386-2888999)3
    1909411  NM_061992.21  NP_494393.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ESS1(YJR017C)4
    ESS11
    Peptidylprolyl-cis/trans-isomerase (PPIase) specific more4
    ESS11
    49.18(n)1
    46.91(a)1
      10(467033-466521)4
    8534751, 4  NP_012551.21, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PIN1AT1 PIN1AT 54.13(n)
    53.21(a)
      816316  NM_127360.3  NP_179395.1 
    rice
    (Oryza sativa)
    Liliopsida Os.376802 Transcribed sequence with strong similarity to protein more 78.85(n)    AU095312.1 


    ENSEMBL Gene Tree for PIN1 (if available)
    TreeFam Gene Tree for PIN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PIN1 gene
    1 SIMAP similar gene for PIN1 using alignment to 6 protein entries:     PIN1_HUMAN (see all proteins):
    PIN1P1

    Find genes that share paralogs with PIN1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PIN1
    PGOHUM00000244752


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PIN1 (see all 271)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs665774851,2
    C,F--9880454(+) AATTAT/CTTTTG 3 -- us2k15Minor allele frequency- C:0.26WA CSA NA 244
    rs1410490661,2
    --9880490(+) CCAGGA/CTGGTC 3 -- us2k10--------
    rs1857914451,2
    --9880592(+) TAATTC/TTTTTG 3 -- us2k10--------
    rs1917307831,2
    --9880598(+) TTTTGA/GTGGGG 3 -- us2k10--------
    rs1913748291,2
    --9884378(+) CTTGGC/TGCACT 3 -- int10--------
    rs1838281391,2
    --9884417(+) TTCTCC/TTGCCT 3 -- int10--------
    rs2016732851,2
    --9884613(+) GCCTG-/TTGTTT
            
    TTGTT
    3 -- int10--------
    rs1895753371,2
    --9884643(+) AGAGTC/TTCACT 3 -- int10--------
    rs1506856121,2
    --9884651(+) ACTCTA/GTCGCT 3 -- int10--------
    rs1391111501,2
    --9884775(+) ACGCCC/TGGCTA 3 -- int10--------

    HapMap Linkage Disequilibrium report for PIN1 (9945883 - 9960365 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PIN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv520683CNV Loss19592680
    esv33490CNV Loss17666407

    Human Gene Mutation Database (HGMD): PIN1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PIN1
    DNA2.0 Custom Variant and Variant Library Synthesis for PIN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601052    OMIM disorders: --

    2 diseases for PIN1:    
    About MalaCards
    adenoid cystic carcinoma    alzheimer's disease


    Find genes that share disorders with PIN1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PIN1 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 52.1 25 18007120 (3), 17361031 (2), 17965833 (2), 19909517 (2) (see all 17)
    frontotemporal dementia 45.6 3 20110589 (1), 19909517 (1), 16480979 (1)
    cancer 40.5 64 15111319 (5), 17965833 (2), 16449657 (2), 17275947 (2) (see all 36)
    neurofibrillary tangles 39.2 2 11212339 (1), 12410395 (1)
    neurodegeneration 30.2 11 16480979 (3), 20110589 (2), 16095818 (2), 17626162 (1) (see all 6)
    breast cancer 28.7 41 19077306 (7), 11533658 (2), 15257284 (2), 11432833 (2) (see all 22)
    tumors 24.8 56 17275947 (4), 15111319 (3), 11432833 (3), 17383430 (3) (see all 26)
    carcinoma squamous cell 18.1 15 12792768 (2), 12579289 (2), 19288014 (2), 19502098 (2) (see all 7)
    neurodegenerative diseases 17.3 8 20110589 (2), 18635547 (2), 19940183 (1), 16480979 (1)
    carcinoma adenoid cystic 15.1 7 16865250 (2), 17129455 (2)

    Genetic Association Database (GAD): PIN1
    Human Genome Epidemiology (HuGE) Navigator: PIN1 (16 documents)

    Export disorders for PIN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIN1 gene, integrated from 10 sources (see all 362):
    (articles sorted by number of sources associating them with PIN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human peptidyl-prolyl isomerase essential for regulation of mitosis. (PubMed id 8606777)1, 2, 3 Lu K.P.... Hunter T. (Nature 1996)
    2. PIN1 gene variants in Alzheimer's disease. (PubMed id 19909517)1, 4, 9 Maruszak A....Zekanowski C. (BMC Med. Genet. 2009)
    3. A novel functional variant (-842G&gt;C) in the PIN1 promoter contributes to decreased risk of squamous cell carcinoma of the head and neck by diminishing the promoter activity. (PubMed id 19625347)1, 4, 9 Lu J....Wei Q. (Carcinogenesis 2009)
    4. Association studies between common variants in prolyl isomerase Pin1 and the risk for late-onset Alzheimer's disease. (PubMed id 17482359)1, 4, 9 Nowotny P....Goate A. (Neurosci. Lett. 2007)
    5. Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients. (PubMed id 16476580)1, 2, 9 Chen J.... Yu L. (Biochem. Biophys. Res. Commun. 2006)
    6. DNA sequence variations in the prolyl isomerase Pin1 gene and Alzheimer's disease. (PubMed id 16095818)1, 4, 9 Poli M....Finazzi D. (Neurosci. Lett. 2005)
    7. PIN-1 promoter polymorphisms in mild cognitive impairment and susceptibility to Alzheimer's disease: a preliminary report. (PubMed id 18007120)1, 4, 9 Arosio B....Vergani C. (Aging Clin Exp Res 2007)
    8. Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function. (PubMed id 21497122)1, 2 Lee T.H.... Lu K.P. (Mol. Cell 2011)
    9. Mitogen-activated protein kinase extracellular signal-regulated kinase 2 phosphorylates and promotes Pin1 protein-dependent promyelocytic leukemia protein turnover. (PubMed id 22033920)1, 2 Lim J.H.... Kao H.Y. (J. Biol. Chem. 2011)
    10. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5300 HGNC: 8988 AceView: PIN1 Ensembl:ENSG00000127445 euGenes: HUgn5300
    ECgene: PIN1 Kegg: 5300 H-InvDB: PIN1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PIN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PIN1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PIN1 gene:
    Search GeneIP for patents involving PIN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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