Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PIM3 Gene

protein-coding   GIFtS: 54
GCID: GC22P050354

pim-3 oncogene
 Explore 10 diseases affiliated with
PIM3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PIM3    

Aliases
for PIM3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Pim-3 Oncogene1 2
EC 2.7.11.13 8
Pim-31
Serine/Threonine Kinase Pim-32
Serine/Threonine-Protein Kinase Pim-32

External Ids:    HGNC: 193101   Entrez Gene: 4151162   Ensembl: ENSG000001983557   OMIM: 6105805   UniProtKB: Q86V863   

Export aliases for PIM3 gene to outside databases

Previous GC identifers: GC00U917025 GC22P048643 GC22P048740 GC22P033300


Summaries
for PIM3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PIM3:
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is
overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the
regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a
selective advantage in tumorigenesis. (provided by RefSeq, Jun 2012)

UniProtKB/Swiss-Prot: PIM3_HUMAN, Q86V86
Function: Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and
protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through
phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle
progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on
tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2),
through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and
PPARGC1A protein levels and cell growth




Genomic Views
for PIM3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PIM3 gene promoter:
         USF1   p53   USF-1:USF-2   CUTL1   HNF-3beta   Egr-4   MZF-1   FAC1   USF-1   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PIM3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PIM3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13

PIM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIM3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P050354:  view genomic region     (about GC identifiers)

Start:
 50,354,143 bp from pter      End:
 50,357,728 bp from pter
Size:
 3,586 bases      Orientation:
 plus strand

Proteins
for PIM3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PIM3_HUMAN, Q86V86 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase pim-3  
Size: 326 amino acids; 35891 Da
Subunit: Interacts with BAD. Interacts with PPP2CA; this interaction promotes dephosphorylation of PIM3, ubiquitination
and proteasomal degradation. Interacts with SOCS6 (By similarity)
Subcellular location: Cytoplasm
Secondary accessions: A5D8X8 A8K7J0 B1B0P0 Q68BM2

Explore the universe of human proteins at neXtProt for PIM3: NX_Q86V86

Post-translational modifications:

  • Ubiquitinated, leading to proteasomal degradation1
  • Phosphorylated. Interaction with PPP2CA promotes dephosphorylation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86V86

    • 4/9 DME Specific Peptides for PIM3 (Q86V86) (see all 9)
     PVAVKHV  KERVTEWG  HRDIKDEN  WCLSLRPS 

    PIM3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001001852.2  
    ENSEMBL proteins: 
     ENSP00000353824  

    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant PIM3 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: PIM3
    OriGene Protein Over-expression Lysate: PIM3
    OriGene Custom Protein Services for PIM3 
    GenScript Custom Purified and Recombinant Proteins Services for PIM3
    Novus Biologicals PIM3 Protein
    Novus Biologicals PIM3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PIM3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--


    PIM3 for ontologies           About GeneDecksing



    PIM3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for PIM3 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PIM3 
    GenScript Custom Superior Antibodies Services for PIM3
    Novus Biologicals PIM3 Antibodies
    Abcam antibodies for PIM3 
    Uscn Antibodies for PIM3
    ThermoFisher Antibodies for PIM3

    Assay Products for PIM3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PIM3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PIM3

    Protein Domains /
    Families
    for PIM3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PIM3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q86V86

    ProtoNet protein and cluster: Q86V86

    UniProtKB/Swiss-Prot: PIM3_HUMAN, Q86V86
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for PIM3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PIM3_HUMAN, Q86V86
    Function: Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and
    protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through
    phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle
    progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on
    tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2),
    through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and
    PPARGC1A protein levels and cell growth
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

    Enzyme Number (IUBMB): EC 2.7.11.11 2

    miRNA
    Products:            		 OriGene 3'-UTR Clone: PIM3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIM3
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate PIM3 (see all 19):
    hsa-miR-3651 hsa-miR-15a hsa-miR-424 hsa-miR-124 hsa-miR-9 hsa-miR-3121-3p hsa-miR-330-3p hsa-miR-506
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PIM3 (see all 7)
    OriGene shRNA RFP: PIM3
    OriGene siRNA: PIM3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIM3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PIM3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIM3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIM3 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PIM3 (NM_001001852)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIM3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PIM3
    Search LifeMap BioReagents cell lines for PIM3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIM3

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity IDA18593906
    GO:0005515protein binding IPI17270021
    GO:0005524ATP binding IEA--


    PIM3 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for PIM3:
     Decreased focal adhesion (FA)   Downregulation of NF-kappaB pa  Wnt reporter downregulated 

    Animal Models:
         Mouse knock-out Pim3tm1Brn for PIM3
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pim3):
     cellular  growth/size  hematopoietic system  immune system  normal 

    PIM3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PIM3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptosis and Autophagy
    		Apoptosis and Autophagy1.00
    2Lymphocyte Signaling
    		Lymphocyte Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for PIM3
        Apoptosis and Autophagy
    Lymphocyte Signaling



    PIM3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PIM3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for PIM3 (Q86V862, 3 ENSP000003538244) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009872, 3, ENSP000004172814MINT-6823587 I2D: score=1 STRING: ENSP00000417281
    BADQ929343, ENSP000003091034I2D: score=1 STRING: ENSP00000309103
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA18593906
    GO:0006915apoptotic process IEA--
    GO:0007049cell cycle IEA--
    GO:0007346regulation of mitotic cell cycle IMP17270021
    GO:0016572histone phosphorylation IEA--


    PIM3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PIM3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PIM3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PIM3

    2 HMDB Compounds for PIM3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    2 Novoseek chemical compound relationships for PIM3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 68.4 6 16818649 (2), 16508102 (1), 15540201 (1), 17876606 (1) (see all 5)
    serine 57.9 6 16818649 (2), 16508102 (1), 15540201 (1), 17876606 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about PIM3 

    Transcripts
    for PIM3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PIM3 gene: 
    NM_001001852.3  

    Unigene Cluster for PIM3:

    Pim-3 oncogene
    Hs.530381  [show with all ESTs]
    Unigene Representative Sequence: NM_001001852
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360612(uc003bjb.3 uc011arj.2) ENST00000467480

    miRNA
    Products:             		 OriGene 3'-UTR Clone: PIM3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIM3
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate PIM3 (see all 19):
    hsa-miR-3651 hsa-miR-15a hsa-miR-424 hsa-miR-124 hsa-miR-9 hsa-miR-3121-3p hsa-miR-330-3p hsa-miR-506
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PIM3 (see all 7)
    OriGene shRNA RFP: PIM3
    OriGene siRNA: PIM3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIM3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIM3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIM3 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PIM3 (NM_001001852)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIM3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PIM3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PIM3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIM3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIM3

    Additional cDNA sequence: 

    AB114795.1 AK292005.1 BC017083.2 BC052239.1 BC064477.1 BC141855.1 

    10 DOTS entries:

    DT.95147709  DT.102845524  DT.97764644  DT.102845521  DT.91764086  DT.100820330  DT.95147711  DT.100820324 
    DT.40223604  DT.120646052 

    24/69 AceView cDNA sequences (see all 69):

    BE396808 AA377883 BE385979 CB178755 CA392046 CB178816 BM352839 AW013971 
    CB178511 BU527864 BM924984 BM352529 BM551740 BM834842 BE783961 CB178565 
    BF204865 BI910679 BM562103 AI636029 BI116752 CD110323 BI561145 BG104200 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PIM3    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
    SP1:        -                                             
    SP2:                    -                                 
    SP3:                                                      
    SP4:                                -     -               
    SP5:                                                      


    ECgene alternative splicing isoforms for PIM3

    Expression
    for PIM3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PIM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATAGTGGCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PIM3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PIM3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PIM3

    SOURCE GeneReport for Unigene cluster: Hs.530381

    UniProtKB/Swiss-Prot: PIM3_HUMAN, Q86V86
    Tissue specificity: Detected in various tissues, including the heart, brain, lung, kidney, spleen, placenta, skeletal
    muscle, and peripheral blood leukocytes. Not found or barely expressed in the normal adult endoderm-derived organs
    such as colon, thymus, liver, or small intestine. However, expression is augmented in premalignant and malignant
    lesions of these organs

        SABiosciences Custom PCR Arrays for PIM3
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PIM3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PIM3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIM3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIM3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIM3

    Orthologs
    for PIM3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PIM3 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC7686551 serine/threonine-protein kinase pim-3-like 77.61(n)
    80.8(a)    		   768655  XM_003640342.1  XP_003640390.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PIM36
    		 --
    		 80(a)
    		 1 ↔ 1
    		 GL343277.1(622507-626545)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1130286
    BX649628.16
    (see all 145)    		 --
    		 72(a)
    52(a)
    (see all 145)    		 1 ↔ 1
    possible ortholog
    (see all 145)    		 25(30652043-30656532)
    6(16965077-16966262)
    worm
    (Caenorhabditis elegans)    		 Secernentea prk-26
    prk-16
    		 Pim (mammalian oncogene) Related Kinase family mem...
    Pim (mammalian oncogene) Related Kinase family mem...
    		 27(a)
    20(a)
    		 many ↔ many
    many ↔ many
    		 III(3363220-3370201)
    III(6990116-7002255)


    ENSEMBL Gene Tree for PIM3 (if available)
    TreeFam Gene Tree for PIM3 (if available) 

    Paralogs
    for PIM3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PIM3 gene
    PIM22  PIM12  PASK2  
    18/20 SIMAP similar genes for PIM3 using alignment to 2 protein entries:     PIM3_HUMAN (see all proteins) (see all similar genes):
    PIM1    PIM2    MARK4    KIAA0999    SIK3    NUAK1
    SIK1    MARK2    NUAK2    Par1b    MARK1    MARK3
    SIK2    SNRK    TRIB1    BRSK2    BRSK1    MELK

    PIM3 for paralogs           About GeneDecksing



    Genomic Variants
    for PIM3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/109 NCBI SNPs in PIM3 are shown (see all 109)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1150359331,2
    		F,--50352220(+) TCACCG/AAGGCC 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs1811448961,2
    		--50352282(+) GAGTGA/GGCGGG 1 -- us2k10--------
    rs1512970291,2
    		--50352314(+) CACACC/TGTGCT 1 -- us2k10--------
    rs1124124251,2
    		--50352592(+) TCCAGC/TATCTC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1865885921,2
    		--50352614(+) GCTGCA/GTGTCC 1 -- us2k10--------
    rs284967281,2
    		C,F,--50352623(+) CCAGCA/GCAGAA 1 -- us2k16Minor allele frequency- G:0.30NA WA EA 364
    rs1889954901,2
    		--50352788(+) GGGTGC/TGTGGT 1 -- us2k10--------
    rs1477336961,2
    		--50352889(+) GGGAGA/GGGCCT 1 -- us2k10--------
    rs1426463961,2
    		--50353004(+) GCAGCA/GGGCGA 1 -- us2k10--------
    rs286398661,2
    		C,F,H,--50353010(+) GGCGAC/TGAAGC 1 -- us2k16Minor allele frequency- T:0.09NS NA WA 908

    HapMap Linkage Disequilibrium report for PIM3 (50354143 - 50357728 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PIM3: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PIM3
    DNA2.0 Custom Variant and Variant Library Synthesis for PIM3

    Disorders / Diseases
    for PIM3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PIM3 for disorders           About GeneDecksing

    OMIM gene information: 610580    OMIM disorders: --

    10 diseases for PIM3:    About MalaCards
    b-cell lymphomas    hepatocellular carcinoma    colon cancer    pancreatic cancer
    pancreatitis    adenoma    adenocarcinoma    carcinoma
    malaria    alcoholism


    Export disorders for PIM3 gene to outside databases

    Publications
    for PIM3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PIM3 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with PIM3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines. (PubMed id 15540201)1, 2, 9 Fujii C.... Mukaida N. (2005)
    2. Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. (PubMed id 18593906)1, 2 Morishita D.... Fujita N. (2008)
    3. Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad- mediated apoptosis. (PubMed id 17270021)1, 2 Popivanova B.K....Mukaida N. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Consistency checks for characterizing protein forms. (PubMed id 12798037)1, 2 Chichester C.... Lisacek F. (2003)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    7. Aberrant Pim-3 expression is involved in gastric adenoma-adenocarcinoma sequence and cancer progression. (PubMed id 17876606)2, 9 Zheng H.C....Takano Y. (2008)
    8. Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines. (PubMed id 16818649)2, 9 Li Y.Y....Mukaida N. (2006)
    9. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    10. A genome-wide association study of DSM-IV cannabis dep endence. (PubMed id 21668797)1 Agrawal A....Bierut L.J. (2011)

    External Searches for PIM3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PIM3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 415116 HGNC: 19310 AceView: PIM3 Ensembl:ENSG00000198355 euGenes: HUgn415116
    ECgene: PIM3 H-InvDB: PIM3

    Other Databases showing PIM3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PIM3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PIM3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PIM3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PIM3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PIM3 gene:
    Search GeneIP for patents involving PIM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for PIM3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Purified and/or Recombinant PIM3 Protein
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for PIM3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PIM3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PIM3  
     OriGene Protein Over-expression Lysate for PIM3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for PIM3   OriGene 3'-UTR Clone for PIM3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIM3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIM3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for PIM3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PIM3   OriGene Custom Protein Services for PIM3  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PIM3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PIM3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIM3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIM3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIM3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIM3
     GenScript Custom Purified and Recombinant Proteins Services for PIM3 GenScript cDNA clones with any tag delivered in your preferred vector for PIM3
     GenScript Custom Assay Services for PIM3 GenScript Custom Superior Antibodies Services for PIM3
     GenScript Custom overexpressing Cell Line Services for PIM3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for PIM3 

     Regulatory tfbs in PIM3 promoter
     Search Chromatin IP Primers for PIM3
     RT2 qPCR Primer Assay in human, mouse, rat PIM3
     Search GNC Networks for PIM3
     SABiosciences Custom PCR Arrays for PIM3
     Search Tocris compounds for PIM3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PIM3 antibodies
     PIM3 proteins
     PIM3 lysates
     Antibodies for PIM3
     See all of Abcam's Antibodies, Kits and Proteins for PIM3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     PIM3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for PIM3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIM3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for PIM3
     SwitchGear Promoter luciferase reporter plasmids for PIM3
     ThermoFisher Antibodies for PIM3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIM3
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      PIM3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4