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Aliases for PIM3 Gene

Aliases for PIM3 Gene

  • Pim-3 Proto-Oncogene, Serine/Threonine Kinase 2 3
  • Pim-3 Oncogene 2 3
  • EC 2.7.11.1 4 63
  • Serine/Threonine Kinase Pim-3 3
  • Pim-3 3

External Ids for PIM3 Gene

Previous GeneCards Identifiers for PIM3 Gene

  • GC00U917025
  • GC22P048643
  • GC22P048740
  • GC22P050354
  • GC22P033300

Summaries for PIM3 Gene

Entrez Gene Summary for PIM3 Gene

  • The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a selective advantage in tumorigenesis. [provided by RefSeq, Jun 2012]

GeneCards Summary for PIM3 Gene

PIM3 (Pim-3 Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Among its related pathways are NF-kappaB Signaling and Apoptosis and Autophagy. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PIM1.

UniProtKB/Swiss-Prot for PIM3 Gene

  • Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIM3 Gene

Genomics for PIM3 Gene

Regulatory Elements for PIM3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PIM3 Gene

Chromosome:
22
Start:
49,960,495 bp from pter
End:
49,964,080 bp from pter
Size:
3,586 bases
Orientation:
Plus strand

Genomic View for PIM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIM3 Gene

Proteins for PIM3 Gene

  • Protein details for PIM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86V86-PIM3_HUMAN
    Recommended name:
    Serine/threonine-protein kinase pim-3
    Protein Accession:
    Q86V86
    Secondary Accessions:
    • A5D8X8
    • A8K7J0
    • B1B0P0
    • Q68BM2

    Protein attributes for PIM3 Gene

    Size:
    326 amino acids
    Molecular mass:
    35891 Da
    Quaternary structure:
    • Interacts with BAD. Interacts with PPP2CA; this interaction promotes dephosphorylation of PIM3, ubiquitination and proteasomal degradation. Interacts with SOCS6 (By similarity).

neXtProt entry for PIM3 Gene

Proteomics data for PIM3 Gene at MOPED

Post-translational modifications for PIM3 Gene

  • Phosphorylated. Interaction with PPP2CA promotes dephosphorylation.
  • Ubiquitinated, leading to proteasomal degradation.
  • Ubiquitination at Lys 5, Lys 38, and Lys 172
  • Modification sites at PhosphoSitePlus

Other Protein References for PIM3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PIM3 (Pim3)

Domains & Families for PIM3 Gene

Gene Families for PIM3 Gene

IUPHAR :

Suggested Antigen Peptide Sequences for PIM3 Gene

Graphical View of Domain Structure for InterPro Entry

Q86V86

UniProtKB/Swiss-Prot:

PIM3_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
genes like me logo Genes that share domains with PIM3: view

Function for PIM3 Gene

Molecular function for PIM3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function:
Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.

Enzyme Numbers (IUBMB) for PIM3 Gene

Gene Ontology (GO) - Molecular Function for PIM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 18593906
GO:0005515 protein binding IPI 17270021
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PIM3: view
genes like me logo Genes that share phenotypes with PIM3: view

Animal Models for PIM3 Gene

MGI Knock Outs for PIM3:

Animal Model Products

No data available for Transcription Factor Targets and HOMER Transcription for PIM3 Gene

Localization for PIM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIM3 Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for PIM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with PIM3: view

No data available for Subcellular locations from COMPARTMENTS for PIM3 Gene

Pathways & Interactions for PIM3 Gene

genes like me logo Genes that share pathways with PIM3: view

Pathways by source for PIM3 Gene

2 Cell Signaling Technology pathways for PIM3 Gene

Gene Ontology (GO) - Biological Process for PIM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 18593906
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0007346 regulation of mitotic cell cycle IMP 17270021
GO:0043066 negative regulation of apoptotic process IMP 17270021
genes like me logo Genes that share ontologies with PIM3: view

No data available for SIGNOR curated interactions for PIM3 Gene

Drugs & Compounds for PIM3 Gene

(10) Drugs for PIM3 Gene - From: HMDB, ApexBio, DGIdb, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
AZD1208 Pharma PIM kinase inhibitor 0
CX-6258 Pharma Pan-Pim kinases Inhibitor 0
SGI-1776 free base Pharma Pim kinase inhibitor,ATP-competitive 0
SMI-4a Pharma Potent Pim inhibitor 0

(1) Additional Compounds for PIM3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with PIM3: view

Transcripts for PIM3 Gene

mRNA/cDNA for PIM3 Gene

Unigene Clusters for PIM3 Gene

Pim-3 oncogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIM3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP2: -
SP3:
SP4: - -
SP5:

Relevant External Links for PIM3 Gene

GeneLoc Exon Structure for
PIM3
ECgene alternative splicing isoforms for
PIM3

Expression for PIM3 Gene

mRNA expression in normal human tissues for PIM3 Gene

Protein differential expression in normal tissues from HIPED for PIM3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PIM3 Gene



SOURCE GeneReport for Unigene cluster for PIM3 Gene Hs.530381

mRNA Expression by UniProt/SwissProt for PIM3 Gene

Q86V86-PIM3_HUMAN
Tissue specificity: Detected in various tissues, including the heart, brain, lung, kidney, spleen, placenta, skeletal muscle, and peripheral blood leukocytes. Not found or barely expressed in the normal adult endoderm-derived organs such as colon, thymus, liver, or small intestine. However, expression is augmented in premalignant and malignant lesions of these organs.
genes like me logo Genes that share expression patterns with PIM3: view

Protein tissue co-expression partners for PIM3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PIM3 Gene

Orthologs for PIM3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PIM3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PIM3 35
  • 91.21 (n)
  • 95.09 (a)
PIM3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pim3 35
  • 89.57 (n)
  • 95.71 (a)
Pim3 16
Pim3 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pim3 35
  • 89.67 (n)
  • 95.71 (a)
dog
(Canis familiaris)
Mammalia PIM3 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIM3 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIM3 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIM3 35
  • 77.71 (n)
  • 80.8 (a)
PIM3 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIM3 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497723 35
  • 71.93 (n)
  • 79.57 (a)
zebrafish
(Danio rerio)
Actinopterygii pim3 36
  • 73 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for PIM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PIM3 Gene

ENSEMBL:
Gene Tree for PIM3 (if available)
TreeFam:
Gene Tree for PIM3 (if available)

Paralogs for PIM3 Gene

Paralogs for PIM3 Gene

(19) SIMAP similar genes for PIM3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PIM3: view

Variants for PIM3 Gene

Sequence variations from dbSNP and Humsavar for PIM3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs13811 -- 49,963,768(-) GGGCC(A/G/T)GGACA utr-variant-3-prime
rs11541019 -- 49,963,712(-) CACCC(A/C)CTCCC utr-variant-3-prime
rs28375915 -- 49,960,607(+) CGCCC(A/G)CCCGA utr-variant-5-prime
rs28424067 -- 49,960,363(+) AAACG(A/G)CTCGC upstream-variant-2KB
rs28465520 -- 49,960,269(+) AAGCG(A/C/G)AGGTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PIM3 Gene

Variant ID Type Subtype PubMed ID
dgv5046n71 CNV Loss 21882294
nsv915495 CNV Loss 21882294
dgv5049n71 CNV Loss 21882294
dgv5050n71 CNV Loss 21882294
nsv915508 CNV Loss 21882294
nsv915512 CNV Gain 21882294
dgv5051n71 CNV Loss 21882294
nsv829329 CNV Gain 20364138
dgv5052n71 CNV Loss 21882294
dgv5053n71 CNV Loss 21882294
nsv915519 CNV Loss 21882294
esv2672626 CNV Deletion 23128226

Variation tolerance for PIM3 Gene

Residual Variation Intolerance Score: 35.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIM3 Gene

HapMap Linkage Disequilibrium report
PIM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIM3 Gene

Disorders for PIM3 Gene

Relevant External Links for PIM3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIM3
genes like me logo Genes that share disorders with PIM3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIM3 Gene

Publications for PIM3 Gene

  1. Aberrant Pim-3 expression is involved in gastric adenoma- adenocarcinoma sequence and cancer progression. (PMID: 17876606) Zheng H.C. … Takano Y. (J. Cancer Res. Clin. Oncol. 2008) 23 67
  2. Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines. (PMID: 16818649) Li Y.Y. … Mukaida N. (Cancer Res. 2006) 23 67
  3. Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines. (PMID: 15540201) Fujii C. … Mukaida N. (Int. J. Cancer 2005) 23 67
  4. Structure and substrate specificity of the Pim-1 kinase. (PMID: 16227208) Bullock A.N. … Turk B.E. (J. Biol. Chem. 2005) 23 67
  5. Expression, purification, crystallization and preliminary crystallographic analysis of human Pim-1 kinase. (PMID: 16508102) Qian K.C. … Farmer B. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2005) 23 67

Products for PIM3 Gene

Sources for PIM3 Gene

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