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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PIM2 Gene

protein-coding   GIFtS: 67
GCID: GC0XM048770

pim-2 oncogene
 Explore 21 diseases affiliated with
PIM2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PIM2    

Aliases
for PIM2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Pim-2 Oncogene1 2     Serine/Threonine Protein Kinase Pim-22
EC 2.7.11.13 8     Serine/Threonine-Protein Kinase Pim-22
Pim-2h3     Pim-2h3
Proto-Oncogene Pim-2 (Serine Threonine Kinase)2     

External Ids:    HGNC: 89871   Entrez Gene: 110402   Ensembl: ENSG000001020967   OMIM: 3002955   UniProtKB: Q9P1W93   

Export aliases for PIM2 gene to outside databases

Previous GC identifers: GC0XM047573 GC0XM047031 GC0XM047816 GC0XM048526 GC0XM048655 GC0XM046426


Summaries
for PIM2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PIM2:
This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded
protein functions to prevent apoptosis and to promote cell survival.(provided by RefSeq, Nov 2009)

UniProtKB/Swiss-Prot: PIM2_HUMAN, Q9P1W9
Function: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts
its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle
progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of
a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an
increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism
between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of
rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling
through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell
survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B
cascade; this process requires phosphorylation of MAP3K8/COT. Isoform 1 is less active in this respect. Promotes
growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved
in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate

Gene Wiki entry for PIM2


Genomic Views
for PIM2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_079573.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PIM2 gene promoter:
         SRF   C/EBPbeta   SRF (504 AA)   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PIM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PIM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

PIM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIM2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM048770:  view genomic region     (about GC identifiers)

Start:
 48,770,459 bp from pter      End:
 48,776,413 bp from pter
Size:
 5,955 bases      Orientation:
 minus strand

Proteins
for PIM2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PIM2_HUMAN, Q9P1W9 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase pim-2  
Size: 311 amino acids; 34190 Da
Subunit: Interacts with MYC (By similarity)
Sequence caution: Sequence=AAC78506.1; Type=Frameshift; Positions=293;
1 PDB 3D structure from and Proteopedia for PIM2:
2IWI (3D)    
Secondary accessions: A8K4G6 Q99739

Explore the universe of human proteins at neXtProt for PIM2: NX_Q9P1W9

Post-translational modifications:

  • Autophosphorylated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P1W9

    • 3 DME Specific Peptides for PIM2 (Q9P1W9)
     HRDIKDEN  GVIRLLDWFE  LLYDMVCGDIPFE 

    PIM2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006866.2  
    ENSEMBL proteins: 
     ENSP00000365692   ENSP00000410960  

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    Uscn Proteins for PIM2


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    Uscn ELISAs and CLIAs for PIM2

    Protein Domains /
    Families
    for PIM2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PIM2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9P1W9

    ProtoNet protein and cluster: Q9P1W9

    UniProtKB/Swiss-Prot: PIM2_HUMAN, Q9P1W9
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for PIM2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PIM2_HUMAN, Q9P1W9
    Function: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts
    its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle
    progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of
    a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an
    increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism
    between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of
    rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling
    through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell
    survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B
    cascade; this process requires phosphorylation of MAP3K8/COT. Isoform 1 is less active in this respect. Promotes
    growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved
    in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Induction: Down-regulated in response to enterovirus 71 (EV71) infection

         Genatlas biochemistry entry for PIM2:
    pim-2 oncogene murine otholog,with a large transcript,expressed in hematopoietic tissues and leukemia and lymphoma cell
    lines,testis (primary germ cells),small intestine,colon and colorectal adenocarcinoma cells. A short transcript can be
    detected only in spleen,tissue,small intestine and colon,potentially involved in proliferating cells as well as during
    meiosis

    Enzyme Number (IUBMB): EC 2.7.11.11 2

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    SwitchGear 3'UTR luciferase reporter plasmid: PIM2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA18593906
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--


    PIM2 for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for PIM2:
     Decreased CYP1A1 activity afte  Decreased POU5F1-GFP protein e  Increased cell death in HCT116  Increases Tamoxifen sensitivit 
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for PIM2: Pim2tm1.1Lex Pim2tm1Brn
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Pim2):
     cellular  growth/size  hematopoietic system  immune system 

    PIM2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PIM2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptosis and Autophagy
    		Apoptosis and Autophagy1.00
    2Lymphocyte Signaling
    		Lymphocyte Signaling1.00
    3Endometrial cancer
    		Acute myeloid leukemia0.39

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for PIM2
        Apoptosis and Autophagy
    Lymphocyte Signaling


    1         Kegg Pathway  (Kegg details for PIM2):
        Acute myeloid leukemia


    PIM2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/15 Interacting proteins for PIM2 (Q9P1W92, 3 ENSP000003656924) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDUFB8O951692, 3, ENSP000002991664MINT-65723 I2D: score=5 STRING: ENSP00000299166
    ATXN1P542532, 3, ENSP000002447694MINT-2869125 I2D: score=3 STRING: ENSP00000244769
    GSK3BP498412, 3, ENSP000003248064MINT-8257570 I2D: score=2 STRING: ENSP00000324806
    MDM2Q009872, 3, ENSP000004172814MINT-6823574 I2D: score=1 STRING: ENSP00000417281
    CUTCQ9NTM92, 3, ENSP000003595074MINT-66534 I2D: score=4 STRING: ENSP00000359507
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IDA--
    GO:0006468protein phosphorylation ISS--
    GO:0007140male meiosis TAS9804974
    GO:0008283cell proliferation TAS9804974
    GO:0008285negative regulation of cell proliferation IDA--


    PIM2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PIM2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PIM2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PIM2

    2 HMDB Compounds for PIM2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    2 Novoseek chemical compound relationships for PIM2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 61.8 3 16508102 (1), 15525646 (1), 16123140 (1)
    serine 53.7 3 16508102 (1), 15525646 (1), 16123140 (1)

    Search CenterWatch for drugs/clinical trials and news about PIM2 

    Transcripts
    for PIM2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PIM2 gene: 
    NM_006875.3  

    Unigene Cluster for PIM2:

    Pim-2 oncogene
    Hs.727148  [show with all ESTs]
    Unigene Representative Sequence: NM_006875
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376509(uc004dls.3) ENST00000485431 ENST00000442430

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    hsa-miR-1226 hsa-miR-3607-3p hsa-miR-429 hsa-miR-1285 hsa-miR-3692 hsa-miR-4314 hsa-miR-3121-3p hsa-miR-3119
    SwitchGear 3'UTR luciferase reporter plasmid: PIM2 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AK290931.1 AK312745.1 BC018111.1 U77735.1 

    9 DOTS entries:

    DT.213231  DT.91840402  DT.92429251  DT.95169107  DT.40116951  DT.121284397  DT.97777014  DT.91956224 
    DT.99978061 

    24/125 AceView cDNA sequences (see all 125):

    CR595611 BP339116 AI080386 AA298669 BX956346 BX363312 AW376458 NM_006875 
    BI253854 BC018111 AI360425 BE218097 BQ921738 BM829012 BP432033 CR600151 
    BM799407 BP368140 AW192430 AI419792 BQ004236 AI950561 AA868876 AU125647 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PIM2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
    SP1:                          -     -                                 
    SP2:                          -                                       
    SP3:                          -     -                                 
    SP4:                                                                  
    SP5:              -           -     -                                 


    ECgene alternative splicing isoforms for PIM2

    Expression
    for PIM2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PIM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTGGAAACC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PIM2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    Rockefeller University embryonic stem cell line 2 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Mesenchymal Progenitor Cells - Passage 2 (Differentiation of ...)
    Matrigel embedded cells (Derivation of cardio...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PIM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PIM2

    SOURCE GeneReport for Unigene cluster: Hs.727148

    UniProtKB/Swiss-Prot: PIM2_HUMAN, Q9P1W9
    Tissue specificity: Highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small
    intestine, colon and colorectal adenocarcinoma cells. Weakly expressed in normal liver, but highly expressed in
    hepatocellular carcinoma tissues

        SABiosciences Expression via Pathway-Focused PCR Array including PIM2: 
              Apoptosis 384HT in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for PIM2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PIM2 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Pim21 , 5 proviral integration site 21, 5 86.39(n)1
    89.39(a)1    		   X (3.55 cM)5
    187151  NM_138606.21  NP_613072.11 
     78782625 
    lizard
    (Anolis carolinensis)    		 Reptilia PIM26
    		 --
    		 65(a)
    		 1 ↔ 1
    		 GL343326.1(1315726-1323614)
    zebrafish
    (Danio rerio)    		 Actinopterygii pim11 pim-1 oncogene 59.58(n)
    57.84(a)    		   58054  NM_131539.1  NP_571614.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea prk-23 serine/threonine kinase 42(a)
    (best of 2)    		   III(3436824-3438531)   --


    ENSEMBL Gene Tree for PIM2 (if available)
    TreeFam Gene Tree for PIM2 (if available) 

    Paralogs
    for PIM2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PIM2 gene
    PIM12  PIM32  PASK2  
    18/47 SIMAP similar genes for PIM2 using alignment to 2 protein entries:     PIM2_HUMAN (see all proteins) (see all similar genes):
    PIM3    PIM1    NUAK1    RPS6KA2    CDKL1    CHEK1
    HUNK    MARK1    PRKACA    Par1b    RPS6KA3    MARK2
    AKT2    BRSK2    PRKACB    CDKL3    PRKCH    MARK3

    PIM2 for paralogs           About GeneDecksing



    Genomic Variants
    for PIM2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/66 NCBI SNPs in PIM2 are shown (see all 66)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1421069121,2
    		C,Fother46427948(+) GCCGGG/AAGTGC 2 /L syn11Minor allele frequency- A:0.00NA 4544
    rs352085421,2
    		C--46427661(+) CAGGAT/CCTCTT 2 /I /V mis11Minor allele frequency- C:0.00NA 2
    rs1438894381,2
    		C,--46429064(+) AAACAC/TTTGAA 1 -- int10--------
    rs30275141,2
    		C,F,O,H,--46431095(-) GCCAGC/TCCATT 1 -- int116--NA NS EA WA CSA 1687
    rs22394521,2
    		C,--46431727(-) GGCAGG/CGGGCT 1 -- int12Minor allele frequency- C:0.33NA CSA 3
    rs30275121,2
    		C,F,H,--46432427(-) GGCGAA/GTCTCA 1 -- ut518Minor allele frequency- G:0.01NA NS EA CSA 541
    rs30275111,2
    		C,F,H--46432788(-) TTAAGT/GGTAAA 1 -- us2k1 tfbs32Minor allele frequency- G:0.01NS NA 228
    rs1383058601,2
    		C,F,--48771474(+) TCCTCG/AGCTGG 2 /A syn11Minor allele frequency- A:0.01NA 2866
    rs1475871551,2
    		F--48771790(+) GTGGCC/TGGGAG 2 P syn11Minor allele frequency- T:0.00NA 4544
    rs1501362761,2
    		C,F--48771800(+) GTGCAT/CGGTAC 2 /H /R mis11Minor allele frequency- C:0.00NA 4542

    HapMap Linkage Disequilibrium report for PIM2 (48770459 - 48776413 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PIM2
         1 CNV: 7789
    Locus Specific Mutation Databases (LSDB): PIM2

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    Disorders / Diseases
    for PIM2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PIM2 for disorders           About GeneDecksing

    OMIM gene information: 300295    OMIM disorders: --

    20/21 diseases for PIM2 (see all 21):    About MalaCards
    non-hodgkin lymphoma    leukemia/lymphoma    mantle cell lymphoma    leukemia/lymphoma, t-cell
    hodgkin's lymphoma    chronic lymphocytic leukemia    acute myeloid leukemia    lymphocytic leukemia
    myeloid leukemia    leukemia    rhabdomyosarcoma    hepatocellular carcinoma
    prostate cancer    myeloma    ataxia    prostatitis
    tuberculosis    adenocarcinoma    carcinoma    malaria

    2 Novoseek disease relationships for PIM2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma 52.8 2 16403219 (1), 18467333 (1)
    cancer 0 1 16403219 (1)


    Export disorders for PIM2 gene to outside databases

    Publications
    for PIM2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PIM2 gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with PIM2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Pim-2 proto-oncogene and its testicular expression. (PubMed id 9804974)1, 2, 3, 9 Baytel D.... Don J. (1998)
    2. Serine/threonine kinase Pim-2 promotes liver tumorigenesis induction through mediating survival and preventing apoptosis of liver cell. (PubMed id 18675992)1, 2, 9 Gong J....Shi Y. (2009)
    3. Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor. (PubMed id 19841674)1, 2 Bullock A.N....Knapp S. (2009)
    4. Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. (PubMed id 18593906)1, 2 Morishita D.... Fujita N. (2008)
    5. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PubMed id 16548883)1, 2 Leong W.F. and Chow V.T. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL. (PubMed id 16403219)1, 9 Macdonald A....Arthur J.S. (2006)
    8. Increased expression of the hPim-2 gene in human chronic lymphocytic leukemia and non-Hodgkin lymphoma. (PubMed id 15291354)1, 9 Cohen A.M....Don J. (2004)
    9. Activation of cell cycle arrest and apoptosis by the p roto-oncogene Pim-2. (PubMed id 22506047)1 Levy D....Don J. (2012)
    10. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)

    External Searches for PIM2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PIM2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11040 HGNC: 8987 AceView: PIM2 Ensembl:ENSG00000102096 euGenes: HUgn11040
    ECgene: PIM2 Kegg: 11040 H-InvDB: PIM2

    Other Databases showing PIM2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PIM2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PIM2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PIM2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PIM2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PIM2 gene:
    Search GeneIP for patents involving PIM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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