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PIM2 Gene

protein-coding   GIFtS: 65
GCID: GC0XM048770

Pim-2 Oncogene

  See PIM2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pim-2 Oncogene1 2     Serine/Threonine Protein Kinase Pim-22
EC 2.7.11.13 8     Serine/Threonine-Protein Kinase Pim-22
pim-2h2     Pim-2h3
Proto-Oncogene Pim-2 (Serine Threonine Kinase)2     

External Ids:    HGNC: 89871   Entrez Gene: 110402   Ensembl: ENSG000001020967   OMIM: 3002955   UniProtKB: Q9P1W93   

Export aliases for PIM2 gene to outside databases

Previous GC identifers: GC0XM047573 GC0XM047031 GC0XM047816 GC0XM048526 GC0XM048655 GC0XM046426


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PIM2 Gene:
This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded
protein functions to prevent apoptosis and to promote cell survival.(provided by RefSeq, Nov 2009)

GeneCards Summary for PIM2 Gene:
PIM2 (pim-2 oncogene) is a protein-coding gene. Diseases associated with PIM2 include colorectal adenocarcinoma, and mantle cell lymphoma. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is PIM1.

UniProtKB/Swiss-Prot: PIM2_HUMAN, Q9P1W9
Function: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.
Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell
cycle progression, the regulation of cap-dependent protein translation and through survival signaling by
phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein
stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might
explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein
translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the
PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the
anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals
via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of
MAP3K8/COT. Isoform 1 is less active in this respect. Promotes growth factor-independent proliferation by
phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of
chondrocyte survival and autophagy in the epiphyseal growth plate

Gene Wiki entry for PIM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PIM2 gene promoter:
         SRF   C/EBPbeta   SRF (504 AA)   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIM2 promoter sequence
   Search Chromatin IP Primers for PIM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

PIM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIM2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM048770:  view genomic region     (about GC identifiers)

Start:
48,770,459 bp from pter      End:
48,776,413 bp from pter
Size:
5,955 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PIM2_HUMAN, Q9P1W9 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase pim-2  
Size: 311 amino acids; 34190 Da
Subunit: Interacts with MYC (By similarity)
Sequence caution: Sequence=AAC78506.1; Type=Frameshift; Positions=293;
1 PDB 3D structure from and Proteopedia for PIM2:
2IWI (3D)    
Secondary accessions: A8K4G6 Q99739

Explore the universe of human proteins at neXtProt for PIM2: NX_Q9P1W9

Explore proteomics data for PIM2 at MOPED

Post-translational modifications: 

  • Autophosphorylated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for PIM2 (Q9P1W9)
     HRDIKDEN  GVIRLLDWFE  LLYDMVCGDIPFE 


    See PIM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006866.2  
    ENSEMBL proteins: 
     ENSP00000365692   ENSP00000410960  

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    Cloud-Clone Corp. Proteins for PIM2

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: pim-2 oncogene
    PIM family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9P1W9

    ProtoNet protein and cluster: Q9P1W9

    UniProtKB/Swiss-Prot: PIM2_HUMAN, Q9P1W9
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with PIM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIM2_HUMAN, Q9P1W9
    Function: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.
    Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell
    cycle progression, the regulation of cap-dependent protein translation and through survival signaling by
    phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein
    stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might
    explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein
    translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the
    PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the
    anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals
    via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of
    MAP3K8/COT. Isoform 1 is less active in this respect. Promotes growth factor-independent proliferation by
    phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of
    chondrocyte survival and autophagy in the epiphyseal growth plate
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Induction: Down-regulated in response to enterovirus 71 (EV71) infection

         Genatlas biochemistry entry for PIM2:
    pim-2 oncogene murine otholog,with a large transcript,expressed in hematopoietic tissues and leukemia and lymphoma
    cell lines,testis (primary germ cells),small intestine,colon and colorectal adenocarcinoma cells. A short
    transcript can be detected only in spleen,tissue,small intestine and colon,potentially involved in proliferating
    cells as well as during meiosis

         Enzyme Number (IUBMB): EC 2.7.11.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA18593906
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with PIM2           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for PIM2:
     Decreased CYP1A1 activity afte  Decreased POU5F1-GFP protein e  Increased cell death in HCT116  Increases Tamoxifen sensitivit 
     Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pim2):
     growth/size/body  hematopoietic system  immune system 

    Find genes that share phenotypes with PIM2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PIM2: Pim2tm1.1Lex Pim2tm1Brn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PIM2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PIM2

    miRNA
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    miRTarBase miRNAs that target PIM2:
    hsa-mir-1226-3p (MIRT036440), hsa-mir-26b-5p (MIRT030307), hsa-mir-24-3p (MIRT030617)

    Block miRNA regulation of human, mouse, rat PIM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PIM2 (see all 18):
    hsa-miR-1226 hsa-miR-3607-3p hsa-miR-429 hsa-miR-1285 hsa-miR-3692 hsa-miR-4314 hsa-miR-3121-3p hsa-miR-3119
    SwitchGear 3'UTR luciferase reporter plasmidPIM2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PIM2

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    Sino Biological Human cDNA Clone for PIM2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIM2
    Addgene plasmids for PIM2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIM2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----

    Find genes that share ontologies with PIM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PIM2 About    
    See pathways by source

    SuperPathContained pathways About
    1Endometrial cancer
    Acute myeloid leukemia0.40
    2Lymphocyte Signaling
    Lymphocyte Signaling
    3Apoptosis and Autophagy
    Apoptosis and Autophagy


    Find genes that share SuperPaths with PIM2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for PIM2
        Apoptosis and Autophagy
    Lymphocyte Signaling



    1 Kegg Pathway  (Kegg details for PIM2):
        Acute myeloid leukemia

        Pathway & Disease-focused RT2 Profiler PCR Array including PIM2: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PIM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for PIM2 (Q9P1W92, 3 ENSP000003656924) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDUFB8O951692, 3, ENSP000002991664MINT-65723 I2D: score=5 STRING: ENSP00000299166
    ATXN1P542532, 3, ENSP000002447694MINT-2869125 I2D: score=3 STRING: ENSP00000244769
    GSK3BP498412, 3, ENSP000003248064MINT-8257570 I2D: score=2 STRING: ENSP00000324806
    MDM2Q009872, 3, ENSP000004172814MINT-6823574 I2D: score=1 STRING: ENSP00000417281
    CUTCQ9NTM92, 3, ENSP000003595074MINT-66534 I2D: score=4 STRING: ENSP00000359507
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IDA--
    GO:0006468protein phosphorylation ISS--
    GO:0007140male meiosis TAS9804974
    GO:0008283cell proliferation TAS9804974
    GO:0008285negative regulation of cell proliferation IDA--

    Find genes that share ontologies with PIM2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    8 ApexBio Compounds for PIM2     About this table
    CompoundAction CAS #
    AZD1208novel, orally bioavailable, highly selective PIM kinase inhibitor[1204144-28-4]
    CX-6258potent, orally efficacious pan-Pim kinases Inhibitor--
    LKB1 (AAK1 dual inhibitor)Pim-1 kinase inhibitor[1093222-27-5]
    PIM-1 Inhibitor 2Potent Pim-1 kinase inhibitor[477845-12-8]
    R8-T198wtCell-permeable peptide inhibitor of Pim-1 kinase--
    SGI-1776 free basepotent ATP-competitive inhibitor of the serine/threonine family of Pim kinase[1025065-69-3]
    SMI-4apotent inhibitor of Pim1[438190-29-5]
    TCS PIM-1 1ATP-competitive Pim-1 kinase inhibitor[491871-58-0]

    Browse Tocris compounds for PIM2

    2 HMDB Compounds for PIM2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 Novoseek inferred chemical compound relationships for PIM2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 61.8 3 16508102 (1), 15525646 (1), 16123140 (1)
    serine 53.7 3 16508102 (1), 15525646 (1), 16123140 (1)



    Find genes that share compounds with PIM2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PIM2 gene: 
    NM_006875.3  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376509(uc004dls.3) ENST00000485431 ENST00000442430
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PIM2 (see all 18):
    hsa-miR-1226 hsa-miR-3607-3p hsa-miR-429 hsa-miR-1285 hsa-miR-3692 hsa-miR-4314 hsa-miR-3121-3p hsa-miR-3119
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      QuantiTect SYBR Green Assays in human, mouse, rat PIM2
      QuantiFast Probe-based Assays in human, mouse, rat PIM2

    Selected AceView cDNA sequences (see all 125):

    BP368140 BP432033 AI419792 BX363312 BP339116 BQ004236 CR595611 AW192430 
    BI253854 BC018111 BE218097 CR600151 BM829012 AI950561 BX956346 AW376458 
    AU124437 BQ921738 BM799407 BP340337 AA868876 NM_006875 AA298669 BM457909 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PIM2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
    SP1:                          -     -                                 
    SP2:                          -                                       
    SP3:                          -     -                                 
    SP4:                                                                  
    SP5:              -           -     -                                 


    ECgene alternative splicing isoforms for PIM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PIM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGGAAACC
    PIM2 Expression
    About this image


    PIM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Cells Epiblast
             Epiblast Stem Cell line 5
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Rockefeller University embryonic stem cell line 2
     
     NULL (Uncategorized)
             Mesenchymal Progenitor Cells - Passage 2
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Spleen (Hematopoietic System)
    PIM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIM2 Protein Expression

    UniProtKB/Swiss-Prot: PIM2_HUMAN, Q9P1W9
    Tissue specificity: Highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small
    intestine, colon and colorectal adenocarcinoma cells. Weakly expressed in normal liver, but highly expressed in
    hepatocellular carcinoma tissues

        Pathway & Disease-focused RT2 Profiler PCR Array including PIM2: 
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PIM2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pim21 , 5 proviral integration site 21, 5 86.39(n)1
    89.39(a)1
      X (3.55 cM)5
    187151  NM_138606.21  NP_613072.11 
     78782625 
    lizard
    (Anolis carolinensis)
    Reptilia PIM26
    pim-2 oncogene
    59(a)
    1 ↔ 1
    GL343326.1(1309499-1324129)
    zebrafish
    (Danio rerio)
    Actinopterygii pim11 pim-1 oncogene 59.45(n)
    57.84(a)
      58054  NM_131539.1  NP_571614.1 


    ENSEMBL Gene Tree for PIM2 (if available)
    TreeFam Gene Tree for PIM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PIM2 gene
    PIM12  PIM32  PASK2  
    Selected SIMAP similar genes for PIM2 using alignment to 2 protein entries:     PIM2_HUMAN (see all proteins) (see all similar genes):
    PIM3    PIM1    NUAK1    RPS6KA2    CDKL1    CHEK1
    HUNK    MARK1    PRKACA    Par1b    RPS6KA3    MARK2
    AKT2    BRSK2    CSNK2A3    CDKL3    PRKCH    MARK3

    Find genes that share paralogs with PIM2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PIM2 (see all 114)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1421069121,2
    C,Funtested148691383(+) GCCGGG/AAGTGC 2 /L syn11Minor allele frequency- A:0.00NA 4544
    rs2010795271,2
    --46430587(+) TCTCC-/AAAAAA 1 -- int10--------
    rs1885427911,2
    C--48689581(+) GTATGC/TAAGGG 1 -- int10--------
    rs1905000981,2
    --48689597(+) ATGGGG/TGAAGA 1 -- int10--------
    rs2000108961,2
    --48689630(+) AGGTG-/ACTACACC 1 -- int10--------
    rs30275151,2
    C--48689824(-) GGAGAT/CACTGT 1 -- int11Minor allele frequency- C:0.00NA 2
    rs1490134351,2
    --48689880(+) GGCAGA/GGGAAT 1 -- int10--------
    rs1436391651,2
    C--48690190(+) ACAATA/CCCGGC 1 -- ut310--------
    rs1830864311,2
    --48690249(+) GAGAAA/CAAACA 1 -- ut310--------
    rs1877363841,2
    --48690509(+) GGTAAA/GCAGCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PIM2 (48770459 - 48776413 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PIM2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6894CNV Insertion18451855
    nsv528292CNV Gain19592680
    esv32909CNV Gain+Loss17666407

    Locus Specific Mutation Databases (LSDB): PIM2

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PIM2
    DNA2.0 Custom Variant and Variant Library Synthesis for PIM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300295    OMIM disorders: --

    2 diseases for PIM2:    
    About MalaCards
    colorectal adenocarcinoma    mantle cell lymphoma


    Find genes that share disorders with PIM2           About GenesLikeMe

    2 Novoseek inferred disease relationships for PIM2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma 52.8 2 16403219 (1), 18467333 (1)
    cancer 0 1 16403219 (1)


    Export disorders for PIM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIM2 gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with PIM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Pim-2 proto-oncogene and its testicular expression. (PubMed id 9804974)1, 2, 3, 9 Baytel D.... Don J. (Biochim. Biophys. Acta 1998)
    2. Serine/threonine kinase Pim-2 promotes liver tumorigenesis induction through mediating survival and preventing apoptosis of liver cell. (PubMed id 18675992)1, 2, 9 Gong J.... Shi Y. (J. Surg. Res. 2009)
    3. Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor. (PubMed id 19841674)1, 2 Bullock A.N.... Knapp S. (PLoS ONE 2009)
    4. Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. (PubMed id 18593906)1, 2 Morishita D.... Fujita N. (Cancer Res. 2008)
    5. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PubMed id 16548883)1, 2 Leong W.F. and Chow V.T. (Cell. Microbiol. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL. (PubMed id 16403219)1, 9 Macdonald A....Arthur J.S. (BMC Cell Biol. 2006)
    8. Increased expression of the hPim-2 gene in human chronic lymphocytic leukemia and non-Hodgkin lymphoma. (PubMed id 15291354)1, 9 Cohen A.M....Don J. (amp 2004)
    9. eIF4B phosphorylation by pim kinases plays a critical role in cellular transformation by Abl oncogenes. (PubMed id 23749639)1 Yang J....Chen J.L. (Cancer Res. 2013)
    10. Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation. (PubMed id 23209281)1 Tahvanainen J....Lahesmaa R. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11040 HGNC: 8987 AceView: PIM2 Ensembl:ENSG00000102096 euGenes: HUgn11040
    ECgene: PIM2 Kegg: 11040 H-InvDB: PIM2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PIM2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PIM2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PIM2 gene:
    Search GeneIP for patents involving PIM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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