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PIM1 Gene

protein-coding   GIFtS: 74
GCID: GC06P037137

Pim-1 Oncogene


(Previous symbol: PIM)
  See PIM1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pim-1 Oncogene1 2     Pim-1 Kinase 44 KDa Isoform2
PIM1 2     Pim-1 Oncogene (Proviral Integration Site 1)2
EC 2.7.11.13 8     Proto-Oncogene Serine/Threonine-Protein Kinase Pim-12
Oncogene PIM12     Serine/Threonine-Protein Kinase Pim-12

External Ids:    HGNC: 89861   Entrez Gene: 52922   Ensembl: ENSG000001371937   OMIM: 1649605   UniProtKB: P113093   

Export aliases for PIM1 gene to outside databases

Previous GC identifers: GC06P037140 GC06P037184 GC06P037245 GC06P036856


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PIM1 Gene:
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is
expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and
in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell
proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and
orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization)
resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and
downstream AUG codons (PMIDs:16186805, 1825810).(provided by RefSeq, Aug 2011)

GeneCards Summary for PIM1 Gene:
PIM1 (pim-1 oncogene) is a protein-coding gene. Diseases associated with PIM1 include nodal marginal zone b-cell lymphoma, and diffuse large b-cell lymphoma. GO annotations related to this gene include manganese ion binding and protein serine/threonine kinase activity. An important paralog of this gene is PIM2.

UniProtKB/Swiss-Prot: PIM1_HUMAN, P11309
Function: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation
and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation
of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition
of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein
stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might
explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling
through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1.
Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity
and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation
and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of
CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the
relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and
tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both
transcriptional and post-translational levels. Phosphorylation of CDKN1B,induces 14-3-3-proteins binding, nuclear
export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by
phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving
functional interaction with the CXCL12-CXCR4 signaling axis

summary for PIM1 Gene:
Pim kinases are constitutively active serine/threonine kinases that promote growth factor-independent
proliferation by phosphorylating, and thus inhibiting, a range of cellular proteins. Both Pim-1 and Pim-2
kinase are serine/threonine kinases that are involved in the control of cell growth, differentiation and
apoptosis.

Gene Wiki entry for PIM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PIM1 gene promoter:
         SRF   Max1   C/EBPbeta   MAZR   AP-1   SRF (504 AA)   ATF-2   Lmo2   E47   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIM1 promoter sequence
   Search Chromatin IP Primers for PIM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.2   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21

PIM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIM1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P037137:  view genomic region     (about GC identifiers)

Start:
37,137,922 bp from pter      End:
37,143,204 bp from pter
Size:
5,283 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PIM1_HUMAN, P11309 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase pim-1  
Size: 404 amino acids; 45412 Da
Cofactor: Magnesium
Subunit: Isoform 2 is isolated as a monomer whereas isoform 1 complexes with other proteins (By similarity). Binds
to RP9 (By similarity). Isoform 1, but not isoform 2, binds BMX. Isoform 2 interacts with CDKN1B and FOXO3.
Interacts with BAD. Interacts with PPP2CA; this interaction promotes dephosphorylation of PIM1, ubiquitination
and proteasomal degradation (By similarity). Interacts with HSP90, this interaction stabilizes PIM1 protein
levels. Interacts (ubiquitinated form) with HSP70 and promotes its proteosomal degradation. Interacts with
CDKN1A. Interacts with CDC25C. Interacts (via N-terminal 96 residues) with CDC25A (By similarity). Interacts with
MAP3K5. Interacts with MYC (By similarity)
Selected PDB 3D structures from and Proteopedia for PIM1 (see all 87):
1XQZ (3D)        1XR1 (3D)        1XWS (3D)        1YHS (3D)        1YI3 (3D)        1YI4 (3D)    
Secondary accessions: Q38RT9 Q5T7H7 Q96RG3
Alternative initiation: 2 isoforms:  P11309-1   P11309-2   (Initiates from CTG codon)

Explore the universe of human proteins at neXtProt for PIM1: NX_P11309

Explore proteomics data for PIM1 at MOPED

Post-translational modifications: 

  • Autophosphorylated on both serine/threonine and tyrosine residues. Phosphorylated. Interaction with PPP2CA
    promotes dephosphorylation1
  • Ubiquitinated, leading to proteasomal degradation1
  • Ubiquitination2 at Lys96, Lys285
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PIM1 (P11309) (see all 10)
     GQVFFRQ  GGFGSVY  HRDIKDEN  DLFDFITE 


    See PIM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001230115.1  NP_002639.1  

    ENSEMBL proteins: 
     ENSP00000362608  

    PIM1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PIM1 Protein
    R&D Systems Recombinant & Natural Proteins for PIM1
    Enzo Life Sciences proteins for PIM1
    OriGene Purified Protein for PIM1
    OriGene Protein Over-expression Lysate for PIM1
    OriGene MassSpec for PIM1
    OriGene Custom Protein Services for PIM1
    GenScript Custom Purified and Recombinant Proteins Services for PIM1
    Novus Biologicals PIM1 Proteins
    Novus Biologicals PIM1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PIM1
    Cloud-Clone Corp. Proteins for PIM1

     
    Search eBioscience for Proteins for PIM1 

     
    antibodies-online proteins for PIM1 (20 products) 

     
    antibodies-online peptides for PIM1

    PIM1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for PIM1 
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    Novus Biologicals PIM1 Antibodies
    Abcam antibodies for PIM1
    Cloud-Clone Corp. Antibodies for PIM1
    ThermoFisher Antibodies for PIM1
    antibodies-online antibodies for PIM1 (143 products) 

    PIM1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript PIM1-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PIM1
    Cloud-Clone Corp. CLIAs for PIM1
    Search eBioscience for ELISAs for PIM1 
    antibodies-online kits for PIM1 (21 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: pim-1 oncogene
    PIM family

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P11309

    ProtoNet protein and cluster: P11309

    UniProtKB/Swiss-Prot: PIM1_HUMAN, P11309
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with PIM1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIM1_HUMAN, P11309
    Function: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation
    and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation
    of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition
    of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein
    stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might
    explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling
    through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1.
    Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity
    and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation
    and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of
    CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the
    relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and
    tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both
    transcriptional and post-translational levels. Phosphorylation of CDKN1B,induces 14-3-3-proteins binding, nuclear
    export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by
    phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving
    functional interaction with the CXCL12-CXCR4 signaling axis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Induction: Strongly induced in leukocytes by the JAK/STAT pathway in response to cytokines. Induced by different
    cellular stresses, heat shock and cytotoxic agents

         Genatlas biochemistry entry for PIM1:
    pim-1 oncogene

         Enzyme Number (IUBMB): EC 2.7.11.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA1825810
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI16186805
    GO:0005524ATP binding IDA1825810
         
    Find genes that share ontologies with PIM1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for PIM1:
     Actin fiber cells  Decreased 12E8 tau but not tot  Decreased substrate adherent c  Upregulation of Wnt/beta-caten 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Pim1):
     cellular  growth/size/body  hematopoietic system  immune system  no phenotypic analysis 
     normal 

    Find genes that share phenotypes with PIM1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pim1tm1Pwl for PIM1

       genOway: Develop your customized and physiologically relevant rodent model for PIM1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PIM1:
    hsa-mir-210-3p (MIRT000151), hsa-mir-33a-5p (MIRT028248), hsa-mir-335-5p (MIRT017680), hsa-mir-16-5p (MIRT006870), hsa-mir-1 (MIRT004322), hsa-mir-192-5p (MIRT004857), hsa-mir-215-5p (MIRT024423)

    Block miRNA regulation of human, mouse, rat PIM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PIM1 (see all 66):
    hsa-miR-15a hsa-miR-877* hsa-miR-629* hsa-miR-208b hsa-miR-3613-3p hsa-miR-2113 hsa-miR-3612 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidPIM1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PIM1
    Predesigned siRNA for gene silencing in human, mouse, rat PIM1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PIM1

    Clone
    Products:
         
    OriGene clones in human, mouse for PIM1 (see all 8)
    OriGene ORF clones in mouse, rat for PIM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PIM1 (NM_002648)
    Sino Biological Human cDNA Clone for PIM1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIM1
    Addgene plasmids for PIM1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PIM1
    Browse ESI BIO Cell Lines and PureStem Progenitors for PIM1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PIM1_HUMAN, P11309: Isoform 2: Cytoplasm. Nucleus
    PIM1_HUMAN, P11309: Isoform 1: Cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol3
    mitochondrion2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA1825810
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----

    Find genes that share ontologies with PIM1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PIM1 About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    IL-6 Pathway0.61
    STAT3 Pathway0.47
    2Development EPO induced Jak STAT pathway
    Development EPO induced Jak STAT pathway0.42
    3Immune response IL 2 activation and signaling pathway
    Immune response IL 3 activation and signaling pathway0.41
    4Endometrial cancer
    Acute myeloid leukemia0.40
    5Validated targets of C-MYC transcriptional activation
    Validated targets of C-MYC transcriptional activation


    Find genes that share SuperPaths with PIM1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PIM1
        STAT3 Pathway
    IL-10 Pathway
    IL-6 Pathway

    2 Cell Signaling Technology (CST) Pathways for PIM1
        Apoptosis and Autophagy
    Lymphocyte Signaling

    2 GeneGo (Thomson Reuters) Pathways for PIM1
        Immune response IL-3 activation and signaling pathway
    Development EPO-induced Jak-STAT pathway

    4 BioSystems Pathways for PIM1
        IL-5 Signaling Pathway
    Role of Calcineurin-dependent NFAT signaling in lymphocytes
    C-MYB transcription factor network
    Validated targets of C-MYC transcriptional activation



    3 Kegg Pathways  (Kegg details for PIM1):
        Jak-STAT signaling pathway
    MicroRNAs in cancer
    Acute myeloid leukemia

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PIM1: 
              Hypoxia Signaling Pathway in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PIM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PIM1 (P113091, 2, 3 ENSP000003626084) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009872, 3, ENSP000004172814MINT-6823555 I2D: score=1 STRING: ENSP00000417281
    BMXP518131, 2, 3, ENSP000003087744EBI-696621,EBI-696657 MINT-68562 MINT-68561 MINT-68560 MINT-68563 I2D: score=2 STRING: ENSP00000308774
    HIST2H3CQ71DI33, ENSP000003581544I2D: score=1 STRING: ENSP00000358154
    HIST2H3AQ71DI33I2D: score=1 
    HIST2H3DQ71DI33I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA16266891
    GO:0006915apoptotic process IEA--
    GO:0007049cell cycle IEA--
    GO:0007275multicellular organismal development TAS2682662
    GO:0008283cell proliferation IDA16186805

    Find genes that share ontologies with PIM1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    8 ApexBio Compounds for PIM1     About this table
    CompoundAction CAS #
    AZD1208novel, orally bioavailable, highly selective PIM kinase inhibitor[1204144-28-4]
    CX-6258potent, orally efficacious pan-Pim kinases Inhibitor--
    LKB1 (AAK1 dual inhibitor)Pim-1 kinase inhibitor[1093222-27-5]
    PIM-1 Inhibitor 2Potent Pim-1 kinase inhibitor[477845-12-8]
    R8-T198wtCell-permeable peptide inhibitor of Pim-1 kinase--
    SGI-1776 free basepotent ATP-competitive inhibitor of the serine/threonine family of Pim kinase[1025065-69-3]
    SMI-4apotent inhibitor of Pim1[438190-29-5]
    TCS PIM-1 1ATP-competitive Pim-1 kinase inhibitor[491871-58-0]

    Compounds for PIM1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PIM-1 Inhibitor 2Pim-1 kinase inhibitor[477845-12-8]
    TCS PIM-1 1 Selective, ATP-competitive Pim-1 kinase inhibitor [491871-58-0]
    R8-T198wtPim-1 kinase inhibitor--
    TCS PIM-1 4a Selective, ATP-competitive Pim kinase inhibitor [438190-29-5]

    3 HMDB Compounds for PIM1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Manganesemanganese 7439-96-5--

    Selected DrugBank Compounds for PIM1 (see all 21)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (3e)-3-[(4-Hydroxyphenyl)Imino]-1h-Indol-2(3h)-One-- --target--17139284 17016423 10592235
    2-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-One-- 154447-36-6target--17139284 17016423 10592235
    3,4-Dihydroxy-1-Methylquinolin-2(1h)-One-- --target--17139284 17016423 10592235
    Rbt205 Inhibitor-- --target--17139284 17016423 10592235
    Adenosine monophosphate5'-Adenosine monophosphate (see all 15)61-19-8targetproduct of17139284 17016423
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target--17139284 17016423
    Phosphonoserine-- --target--17139284 17016423
    S,S-(2-Hydroxyethyl)Thiocysteine-- --target--17139284 17016423
    Staurosporine-- 62996-74-1target--17139284 17016423
    (2S)-1,3-benzothiazol-2-yl{2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}ethanenitrile-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for PIM1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 78 44 1713213 (4), 9099695 (2), 19687226 (2), 11591366 (2) (see all 35)
    serine 67.6 46 1713213 (4), 10664448 (3), 9099695 (2), 11591366 (2) (see all 33)
    tyrosine 46.4 16 7527668 (3), 14764533 (1), 1713213 (1), 9099695 (1) (see all 12)
    amp-pnp 46 4 15808862 (2), 16227208 (1)
    gp 130 38.1 3 10626893 (2), 18292512 (1)
    geldanamycin 35 3 15798097 (1), 11237709 (1)
    rapamycin 21.2 1 16123140 (1)
    ionomycin 11.1 6 7704900 (4), 9419425 (1)
    proline 8.63 1 15808862 (1)
    atp 0 5 15808862 (2), 15525646 (1), 16227208 (1)



    Find genes that share compounds with PIM1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PIM1 gene (2 alternative transcripts): 
    NM_001243186.1  NM_002648.3  

    Unigene Cluster for PIM1:

    Pim-1 oncogene
    Hs.81170  [show with all ESTs]
    Unigene Representative Sequence: DQ022562
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373509(uc003onk.3 uc011dtw.2) ENST00000468243 ENST00000479509

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    Additional mRNA sequence: 

    AK301158.1 AK301314.1 AK309347.1 BC020224.1 DQ022562.1 M16750.1 M24779.1 M54915.1 

    12 DOTS entries:

    DT.95170010  DT.99929343  DT.100776124  DT.100817023  DT.121312366  DT.121312377  DT.100817025  DT.100817029 
    DT.92362239  DT.95190821  DT.121312383  DT.91762631 

    Selected AceView cDNA sequences (see all 238):

    BM756311 AU142969 BE302402 AL528148 AA812195 BM740943 CA306464 AI273750 
    AA934565 AI133460 CR591847 AA844833 CN481625 T55957 BM824680 AW949330 
    BQ183003 AL528149 BM823689 AI126985 BQ647774 AA411092 BM719990 AI376098 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PIM1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c
    SP1:                                            -     -     -                           
    SP2:                                -                                                   
    SP3:                                                                                    
    SP4:                                                        -                           
    SP5:        -     -                                                                     


    ECgene alternative splicing isoforms for PIM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PIM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAGTATACA
    PIM1 Expression
    About this image


    PIM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Thoracic Perivascular Adipose
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical Veins
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Basophils Peripheral Blood
     
     Esophagus (Gastrointestinal Tract)
    PIM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.81170

    UniProtKB/Swiss-Prot: PIM1_HUMAN, P11309
    Tissue specificity: Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform
    2 are both expressed in prostate cancer cell lines

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PIM1: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PIM1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pim11 , 5 proviral integration site 11, 5 89.88(n)1
    94.25(a)1
      17 (15.38 cM)5
    187121  NM_008842.31  NP_032868.21 
     294910455 
    chicken
    (Gallus gallus)
    Aves PIM11 pim-1 oncogene 78.61(n)
    83.39(a)
      100858838  XM_003642712.2  XP_003642760.1 
    lizard
    (Anolis carolinensis)
    Reptilia PIM16
    pim-1 oncogene
    85(a)
    1 ↔ 1
    GL343382.1(247657-253681)
    African clawed frog
    (Xenopus laevis)
    Amphibia pim1-A-prov2 pim-1 oncogene 75.85(n)    L29495.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pim12 pim-1 oncogene 75.91(n)   58054  BC045836.1 
    worm
    (Caenorhabditis elegans)
    Secernentea prk-21 , 3 serine/threonine kinase3
    prk-21
    45(a)
    (best of 2)3
    52.31(n)1
    45.77(a)1
      III(3436824-3438531)3
    1754371  NM_065295.51  NP_497696.21 


    ENSEMBL Gene Tree for PIM1 (if available)
    TreeFam Gene Tree for PIM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PIM1 gene
    PIM22  PIM32  PASK2  
    2 SIMAP similar genes for PIM1 using alignment to 1 protein entry:     PIM1_HUMAN:
    PIM3    PIM2

    Find genes that share paralogs with PIM1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PIM1 (see all 202)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0410044
    A colorectal adenocarcinoma sample4--see VAR_0410042 Y H mis40--------
    rs789270141,2
    C,F--37135963(+) CAATTG/ATTTCC 2 -- us2k12Minor allele frequency- A:0.09WA EA 238
    rs360920471,2
    C,F,H--37136100(+) TCTGTT/CTGACT 2 -- us2k111Minor allele frequency- C:0.02MN NS NA 1284
    rs1816989781,2
    --37136186(+) TGTTCA/GGTGCC 2 -- us2k10--------
    rs1451423691,2
    --37136231(+) TTGAAC/TACTCA 2 -- us2k10--------
    rs1390120861,2
    --37136284(+) TATGAC/TCCTGT 2 -- us2k10--------
    rs94705101,2
    C,F--37136297(+) CATCCT/AATTTA 2 -- us2k1 tfbs35Minor allele frequency- A:0.01MN 408
    rs1854176761,2
    --37136384(+) AGTTCC/GGCCAC 2 -- us2k10--------
    rs1884564821,2
    --37136432(+) GGATAA/CATTCA 2 -- us2k10--------
    rs1812664361,2
    --37136446(+) AAGTTA/GTGGAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PIM1 (37137922 - 37143204 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PIM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5264CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PIM1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164960    OMIM disorders: --

    5 diseases for PIM1:    
    About MalaCards
    nodal marginal zone b-cell lymphoma    diffuse large b-cell lymphoma    marginal zone b-cell lymphoma    prostate cancer
    lung cancer


    Find genes that share disorders with PIM1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PIM1 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemogenesis 65.1 4 19687226 (2), 11237709 (1)
    prostate cancer 44.2 36 20215828 (6), 13679438 (3), 16186805 (3), 14981536 (3) (see all 14)
    leukemia 40.8 8 19703513 (5), 11368509 (1), 15498859 (1)
    lymphoma 38.5 11 9867250 (1), 16403219 (1), 8847898 (1), 15798097 (1) (see all 8)
    primary central nervous system lymphoma 32.7 1 16418334 (1)
    prostatic intraepithelial neoplasia 30.6 3 15264249 (2), 16505280 (1)
    solid tumor 29.3 6 19483729 (3), 14978971 (1)
    cancer 25.6 26 19568408 (3), 15264249 (2), 18708761 (2), 16403219 (1) (see all 12)
    tumors 24.8 33 18695914 (3), 20215828 (2), 16123140 (2), 15799824 (1) (see all 21)
    lymphoma b-cell 22.6 2 16418334 (1)

    Genetic Association Database (GAD): PIM1
    Human Genome Epidemiology (HuGE) Navigator: PIM1 (16 documents)
    Tumor Gene Database (TGDB): PIM1

    Export disorders for PIM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIM1 gene, integrated from 10 sources (see all 261):
    (articles sorted by number of sources associating them with PIM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma. (PubMed id 15808862)1, 2, 9 Kumar A.... Bremer R. (J. Mol. Biol. 2005)
    2. Pim-1 protein kinase is nuclear in Burkitt's lymphoma: nuclear localization is necessary for its biologic effects. (PubMed id 12680209)1, 2, 9 Ionov Y.... Kraft A.S. (Anticancer Res. 2003)
    3. Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase. (PubMed id 12431783)1, 2, 9 Wang Z....Magnuson N.S. (Biochim. Biophys. Acta 2002)
    4. Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1. (PubMed id 10664448)1, 2, 9 Koike N.... Iguchi-Ariga S.M.M. (FEBS Lett. 2000)
    5. Pim-1 kinase stability is regulated by heat shock proteins and the ubiquitin-proteasome pathway. (PubMed id 15798097)1, 2, 9 Shay K.P.... Magnuson N.S. (Mol. Cancer Res. 2005)
    6. Primary structure of the putative human oncogene, pim-1. (PubMed id 2205533)1, 2, 9 Reeves R.... Power M. (Gene 1990)
    7. The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs. (PubMed id 16186805)1, 2, 9 Xie Y.... Qiu Y. (Oncogene 2006)
    8. The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C. (PubMed id 16356754)1, 2, 9 Bachmann M.... Moroy T. (Int. J. Biochem. Cell Biol. 2006)
    9. IL-5 and granulocyte-macrophage colony-stimulating factor activate STAT3 and STAT5 and promote Pim-1 and cyclin D3 protein expression in human eosinophils. (PubMed id 15528381)1, 2, 9 Stout B.A.... Bertics P.J. (J. Immunol. 2004)
    10. Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. (PubMed id 18593906)1, 2, 9 Morishita D.... Fujita N. (Cancer Res. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5292 HGNC: 8986 AceView: PIM1 Ensembl:ENSG00000137193 euGenes: HUgn5292
    ECgene: PIM1 Kegg: 5292 H-InvDB: PIM1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PIM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PIM1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PIM1 gene:
    Search GeneIP for patents involving PIM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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