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PIM1 Gene

protein-coding GIFtS: 72

GC06P037245

pim-1 oncogene
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PIM)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.11.1 ^³
OTTHUMP00000018046 ^²
PIM ^²

Descriptions
Oncogene PIM1 ^²
non-specific serine/threonine protein kinase ^²
pim-1 kinase 44 kDa isoform ^²
pim-1 oncogene ^²
pim-1 oncogene (proviral integration site 1) ^²

External Ids
HGNC: 8986¹
Entrez Gene: 5292²
UniProtKB: P11309³
Ensembl: ENSG00000137193⁷

Search outside databases for aliases for PIM1 gene

Previous GC identifers: GC06P037140 GC06P037184

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PIM1:

The protooncogene PIM1 encodes a protein kinase upregulated in prostate cancer (Dhanasekaran et

al., 2001 [PubMed 11518967]).[supplied by OMIM]

UniProtKB/Swiss-Prot: PIM1_HUMAN, P11309

Function: Plays a role in signal transduction in blood cells. Contributes to both cell

proliferation and survival and thus provide a selective advantage in tumorigenesis. May affect the

structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3

Gene Wiki entry for PIM1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PIM1 gene

Entrez Gene cytogenetic band: 6p21.2 Ensembl cytogenetic band: 6p21.2 HGNC cytogenetic band: 6p21

PIM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P037245: (about GC identifiers)

Start:	37,245,964 bp from pter
End:	37,251,182 bp from pter
Size:	5,219 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000006.10 NT_007592.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PIM1_HUMAN, P11309 (See protein sequence)

Recommended Name: Proto-oncogene serine/threonine-protein kinase Pim-1

Size: 404 amino acids; 45412 Da

Cofactor: Manganese

Subunit: Binds to RP9. Isoform 2 is isolated as a monomer whereas isoform 1 complexes with other

proteins. Isoform 1, but not isoform 2, binds BMX

Subcellular location: Isoform 2: Cytoplasm. Nucleus

Subcellular location: Isoform 1: Cell membrane

PDB structures from and Proteopedia :

1XQZ (3D)

1XR1 (3D)

1XWS (3D)

1YHS (3D)

1YI3 (3D)

1YI4 (3D)

1YWV (3D)

1YXS (3D)

1YXT (3D)

1YXU (3D)

1YXV (3D)

1YXX (3D)

2BIK (3D)

2BIL (3D)

2BZH (3D)

2BZI (3D)

2BZJ (3D)

2BZK (3D)

2C3I (3D)

2J2I (3D)

2O3P (3D)

2O63 (3D)

2O64 (3D)

2O65 (3D)

2OBJ (3D)

2OI4 (3D)

3BGP (3D)

3BGQ (3D)

3BGZ (3D)

3BWF (3D)

3C4E (3D)

3CXW (3D)

3CY2 (3D)

3CY3 (3D)

3DCV (3D)

3F2A (3D)

Secondary accessions: Q38RT9 Q96RG3

Alternative initiation: 2 isoforms: P11309-1 P11309-2

Post-translational modifications:

Autophosphorylated on both serine/threonine and tyrosine residues¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002639.1

ENSEMBL proteins:

ENSP00000362608 ENSP00000362606

Human Recombinant Proteins

	Invitrogen human recombinant proteins for PIM1
	Millipore Purified and/or Recombinant PIM1 Protein
	Sigma-Aldrich Proteins and CompoZr ZFN for PIM1
	R&D Systems Recombinant & Natural Proteins for PIM1
	Enzo Life Sciences proteins for PIM1
	Recombinant Proteins from Abcam (PIM1)
	Human Recombinant Proteins from Abnova (PIM1)

OriGene Purified Recombinant Human Protein: PIM1

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IDA	1825810
GO:0005886	plasma membrane	IEA	--

About this table

Antibodies for PIM1:

	Invitrogen Antibodies for PIM1
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PIM1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for PIM1 (Pim-1)
	Antibodies from Abcam (PIM1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PIM1)
	Novus Biologicals Antibodies for PIM1

Assays for PIM1:

	Invitrogen Assays for PIM1
	Millipore Kits and Assays for the Analysis of PIM1
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P11309

ProtoNet protein and cluster: P11309

UniProtKB/Swiss-Prot: PIM1_HUMAN, P11309

Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM

subfamily

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PIM1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PIM1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002648

Applied Biosystems Silencer® siRNAs for PIM1

Sigma-Aldrich siRNA and siRNA Panels for PIM1

Sigma-Aldrich shRNA Panels and shRNA for PIM1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PIM1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002648
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002648
untagged cDNA clones in CMV expression vector (see all 2): NM_002648

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002648

UniProtKB/Swiss-Prot: PIM1_HUMAN, P11309

Function: Plays a role in signal transduction in blood cells. Contributes to both cell

proliferation and survival and thus provide a selective advantage in tumorigenesis. May affect the

structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Induction: Strongly induced in leukocytes by the JAK/STAT pathway in response to cytokines

Enzyme Number (IUBMB): EC 2.7.11.1

Genatlas biochemistry entry for PIM1:

pim-1 oncogene

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pim1):

growth/size

hematopoietic system

immune system

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004674	protein serine/threonine kinase activity	IDA	1825810
GO:0005515	protein binding	IPI	16186805 18056989
GO:0005524	ATP binding	IDA	1825810
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for PIM1 (Your Favorite Gene powered by Ingenuity)

GM-CSF Signaling
Acute Myeloid Leukemia Signaling
Inositol Phosphate Metabolism
Nicotinate and Nicotinamide Metabolism

GeneDecks PIM1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for PIM1

5/26 Interacting proteins for PIM1 (P11309^{1, 2} ENSP00000362606³) via UniProtKB, MINT, and/or STRING (see all 26 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABCG2	Q9UNQ0¹, ENSP00000237612³	EBI-1018629, EBI-1569435 STRING (score=.901)
MDM2	Q00987², ENSP00000258149³	MINT-6823555 STRING (score=.852)
BMX	P51813¹^,²	EBI-696621, EBI-696657 MINT-68562 MINT-68561 MINT-68560 MINT-68563 EBI-696621, EBI-696657 MINT-68562 MINT-68561 MINT-68560 MINT-68563
BMX	P51813¹^,²	EBI-696621, EBI-696657 MINT-68562 MINT-68561 MINT-68560 MINT-68563 EBI-696621, EBI-696657 MINT-68562 MINT-68561 MINT-68560 MINT-68563
NFATC1	ENSP00000327850³	STRING (score=.975)

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	IDA	1825810
GO:0007275	multicellular organismal development	TAS	2682662
GO:0008283	cell proliferation	IDA	16186805
GO:0043066	negative regulation of apoptosis	IDA	16186805

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for PIM1 available from Tocris Bioscience

Compound	Action	CAS number
PIM-1 Inhibitor 2	Pim-1 kinase inhibitor	[477845-12-8]
TCS PIM-1 1	Selective, ATP-competitive Pim-1 kinase inhibitor

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9 Novoseek chemical compound relationships for PIM1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	77.22	39	1713213 (4), 9099695 (2), 11591366 (2), 7704900 (1) (see all 32)
amp-pnp	47.66	4	15808862 (2), 16227208 (1)
tyrosine	47.44	15	7527668 (3), 14764533 (1), 1713213 (1), 9099695 (1) (see all 11)
gp 130	40.02	3	10626893 (2), 18292512 (1)
ionomycin	12.87	6	7704900 (4), 9419425 (1)
proline	11.12	1	15808862 (1)
atp	0.00	5	15808862 (2), 15525646 (1), 16227208 (1)
hydrogen	0.00	4	15808862 (2), 18790640 (1), 15525646 (1)
calcium	0.00	4	7704900 (1), 16403219 (1), 7594647 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PIM1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PIM1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002648

Sigma-Aldrich siRNA and siRNA Panels for PIM1

Sigma-Aldrich shRNA Panels and shRNA for PIM1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002648

REFSEQ mRNAs for PIM1 gene:

NM_002648.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002648

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002648
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002648
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002648

Additional cDNA sequence:

AK301158.1 AK301314.1 AK309347.1 BC020224.1 CR591847.1 DQ022562.1 M16750.1 M24779.1

M54915.1

12 DOTS entries:

DT.95170010 DT.99929343 DT.100776124 DT.121312366 DT.121312377 DT.100817023 DT.100817025 DT.100817029

DT.91762631 DT.92362239 DT.95190821 DT.121312383

24/238 AceView cDNA sequences (see all 238 ):

D57905 AA812195 BQ183003 BM824680 BU739833 CA431420 BX483333 BM823689

AA844833 BU623403 AI133460 CN481625 AA411092 BM740943 T55957 BQ647774

AA928975 AU142969 CA306464 CR591847 AL528149 AL528148 AI376098 BM756311

highest scoring ESTs for PIM1:

M16750 M54915 AA004462 AA005379 AA069282 AA115475 AA115609 AA232041 AA232339 AA292377

Unigene Cluster for PIM1:

Pim-1 oncogene

Hs.81170 [show with all ESTs]

Unigene Representative Sequence: DQ022562

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for PIM1

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	·	8c
SP1:															-		-		-
SP2:											-
SP3:
SP4:																			-
SP5:			-		-

About this scheme

ECgene alternative splicing isoforms for PIM1

2 Ensembl transcripts including schematic representations:

ENST00000373509 ENST00000373507

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PIM1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PIM1

¹ / ² / ³

4 probe-sets matching PIM1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1779_s_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.95	M16750	1.00	1.00	1.00	1
883_s_at²^{, 3}	U95-A	1	1.00	1.00	0.94	1.05	M54915	1.00	1.00	1.00	1
209193_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M24779	0.80	1.00	0.91	1
209193_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks PIM1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTAGTATACA

SOURCE GeneReport for Unigene cluster: Hs.81170
Expression variation in blood from EXPOLDB for PIM1
UniProtKB/Swiss-Prot: PIM1_HUMAN, P11309
Tissue specificity: Expressed primarily in cells of the hematopoietic and germline lineages.
Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PIM1 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PIM1¹	--	pim-1 oncogene	95.53(n) 99.04(a)	481772 XM_538893.2 XP_538893.2
cow (Bos taurus)	PIM1¹	--	pim-1 oncogene	94.78(n) 98.72(a)	281402 NM_174144.2 NP_776569.1
rat (Rattus norvegicus)	Pim1¹	--	pim-1 oncogene	89.99(n) 97.12(a)	24649 NM_017034.1 NP_058730.1
mouse (Mus musculus)	Pim1^{1, 5}	17 (16.40 cM)⁵	proviral integration site 1^{1, 5}	89.88(n)¹ 94.25(a)¹	18712¹ NM_008842.2¹ NP_032868.2¹ AK047301⁵ AK154127⁵ (see all 12)
zebrafish (Danio rerio)	pim1²	--	pim-1 oncogene	75.91(n)	58054 BC045836.1

About this table Species with no ortholog for PIM1

ENSEMBL Gene Tree for PIM1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PIM1 gene

PIM2² PIM3² PASK²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/60 NCBI SNPs in PIM1 are shown (see all 60 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 38)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs10507^1,2	A,C,F,H	37250400(+)	`CTGTCC/TTCCCT`	1	--	ut3¹		18		EA NA MN CSAM EU WA	1398
	rs262935^1,2	C,F,H	37245404(+)	`CAAAAA/CCCTCA`	1	--	ng5¹		5		MN EU EA	662
	rs9470511^1,2	C,F	37249859(+)	`CTGGCA/TGGTCC`	1	--	ut3¹ ese³		5		MN CSAM EA	408
	rs2070892^1,2	C,F	37250012(+)	`GCTGCC/ATCCCA`	1	--	ut3¹ ese³		5		MN CSAM EA	400
--	rs9470510^1,2	C,F	37244275(+)	`CATCCT/AATTTA`	1	--	ng5¹ tfbs³		5		MN CSAM EA	408
--	rs12197850^1,2	C,F	37249940(+)	`TCTCGC/ACAAGC`	1	--	ut3¹		5		MN CSAM EA	408
--	rs262936^1,2	A,F	37246198(+)	`gcagcG/Cacagc`	1	--	ut5¹ ese³		1		MN	184
	rs262928^1,2	A,C	37251635(+)	`TGAGCA/GTGTCC`	1	--	ng3¹		0	--	--	--	--
--	rs35111462^1,2	C,F	37249939(+)	`GTCTCG/TCCAAG`	1	--	ut3¹		5		MN CSAM EA	408
	rs35760989^1,2	C,F	37247008(+)	`GGCCCG/CAGCCG`	1	Q/E	mis¹		4		EU EA WA	420

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HapMap Linkage Disequilibrium images for PIM1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 164960

10/17 Novoseek disease relationships for PIM1 gene (see all 17 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemogenesis	64.48	1	11237709 (1)
lymphoma	40.62	11	9867250 (1), 16403219 (1), 8847898 (1), 15798097 (1) (see all 8)
prostate cancer	38.56	26	13679438 (3), 16186805 (3), 14981536 (3), 17908456 (2) (see all 11)
primary central nervous system lymphoma	34.80	1	16418334 (1)
leukemia	33.27	2	11368509 (1), 15498859 (1)
prostatic intraepithelial neoplasia	32.69	3	15264249 (2), 16505280 (1)
lymphoma b-cell	25.65	2	16418334 (1)
myeloid leukemia	18.83	1	1314369 (1)
cancer	16.41	16	15264249 (2), 18708761 (2), 16403219 (1), 15067357 (1) (see all 9)
tumors	16.22	25	18695914 (3), 16123140 (2), 15799824 (1), 18181176 (1) (see all 15)

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1 PharmGKB disease relationship for PIM1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872 12730115

About this table

Human Genome Epidemiology Navigator: PIM1 (5 documents)
Tumor Gene Database: PIM1

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/175 PubMed articles for PIM1 gene (see all 175 ):

Pim-1 protein kinase is nuclear in Burkitt's lymphoma: nuclear localization is necessary for its biologic effects. (PubMed id 12680209)^{1, 3, 4} Ionov Y.... Kraft A.S. (2003)
Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1. (PubMed id 10664448)^{1, 3, 4} Koike N.... Iguchi-Ariga S.M.M. (2000)
Primary structure of the putative human oncogene, pim-1. (PubMed id 2205533)^{1, 3, 4} Reeves R.... Power M. (1990)
The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs. (PubMed id 16186805)^{1, 3, 4} Xie Y.... Qiu Y. (2006)
IL-5 and granulocyte-macrophage colony-stimulating factor activate STAT3 and STAT5 and promote Pim-1 and cyclin D3 protein expression in human eosinophils. (PubMed id 15528381)^{1, 3, 4} Stout B.A.... Bertics P.J. (2004)
The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG. (PubMed id 1825810)^{1, 3, 4} Saris C.J.... Berns A. (1991)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Hypermutation of multiple proto-oncogenes in B-cell diffuse large- cell lymphomas. (PubMed id 11460166)^{3, 4} Pasqualucci L.... Dalla-Favera R. (2001)
Identification of the human pim-1 gene product as a 33-kilodalton cytoplasmic protein with tyrosine kinase activity. (PubMed id 2837645)^{3, 4} Telerman A.... Givol D. (1988)
Comparison of the human and mouse PIM-1 cDNAs: nucleotide sequence and immunological identification of the in vitro synthesized PIM-1 protein. (PubMed id 3329709)^{3, 4} Domen J....Berns A. (1987)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5292	HGNC: 8986	AceView: PIM1	Ensembl:ENSG00000137193	euGenes: HUgn5292
ECgene: PIM1	H-InvDB: PIM1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for PIM1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for PIM1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PIM1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PIM1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PIM1		Antibodies for PIM1
	Explore super-pooled esiRNAs		Proteins for PIM1
	Lentivirus-delivered shRNAs for PIM1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PIM1)
	Antibodies (PIM1)
	Chimera RNAi (PIM1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for PIM1 (Pim-1)

	Recombinant Proteins (PIM1)
	Antibodies (PIM1)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for PIM1

	Proteins for PIM1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PIM1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
PIM1 Gene at Home site.
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PIM1 Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for PIM1

Summaries
for PIM1

Genomic Location
for PIM1

Proteins
for PIM1

Protein Domains/
Families
for PIM1

Gene Function
for PIM1

Pathways & Interactions
for PIM1

Drugs & Compounds
for PIM1

Transcripts
for PIM1

Expression
for PIM1

Orthologs
for PIM1

Paralogs
for PIM1

SNPs/Variants
for PIM1

Disorders & Mutations
for PIM1

Medical News
for PIM1

Publications
for PIM1

Search for PIM1

Genome Databases showing PIM1

Other Databases showing PIM1

Specialized Databases showing PIM1

Licensable Technologies
for PIM1

Services
for PIM1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PIM1 Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor PIM1

Summariesfor PIM1

Genomic Locationfor PIM1

Proteinsfor PIM1

Protein Domains/Familiesfor PIM1

Gene Functionfor PIM1

Pathways & Interactionsfor PIM1

Drugs & Compoundsfor PIM1

Transcriptsfor PIM1

Expression for PIM1

Orthologsfor PIM1

Paralogsfor PIM1

SNPs/Variantsfor PIM1

Disorders & Mutationsfor PIM1

Medical Newsfor PIM1

Publicationsfor PIM1

Search for PIM1

Genome Databases showing PIM1

Other Databases showing PIM1

Specialized Databases showing PIM1

Licensable Technologiesfor PIM1

Servicesfor PIM1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PIM1

Summaries
for PIM1

Genomic Location
for PIM1

Proteins
for PIM1

Protein Domains/
Families
for PIM1

Gene Function
for PIM1

Pathways & Interactions
for PIM1

Drugs & Compounds
for PIM1

Transcripts
for PIM1

Expression
for PIM1

Orthologs
for PIM1

Paralogs
for PIM1

SNPs/Variants
for PIM1

Disorders & Mutations
for PIM1

Medical News
for PIM1

Publications
for PIM1

Licensable Technologies
for PIM1

Services
for PIM1