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Aliases for PILRB Gene

Aliases for PILRB Gene

  • Paired Immunoglobin-Like Type 2 Receptor Beta 2 3 5
  • Activating Receptor PILR-Beta 3 4
  • Cell Surface Receptor FDFACT 3 4
  • Paired Immunoglobulin-Like Type 2 Receptor Beta 3
  • Paired Immunoglobulin-Like Receptor Beta 3
  • Paired Immunoglobin-Like Receptor Beta 3
  • Cell Surface Receptor FDFACT1 3
  • Cell Surface Receptor FDFACT2 3
  • Activating Receptor PILRbeta 3
  • FDFACT1 3
  • FDFACT2 3
  • FDFACT 4

External Ids for PILRB Gene

Previous GeneCards Identifiers for PILRB Gene

  • GC07P099546
  • GC07P099545
  • GC07P099578
  • GC07P099771
  • GC07P099936
  • GC07P099938
  • GC07P094588
  • GC07P099940
  • GC07P099945

Summaries for PILRB Gene

Entrez Gene Summary for PILRB Gene

  • The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. [provided by RefSeq, Jun 2013]

GeneCards Summary for PILRB Gene

PILRB (Paired Immunoglobin-Like Type 2 Receptor Beta) is a Protein Coding gene. An important paralog of this gene is PILRA.

UniProtKB/Swiss-Prot for PILRB Gene

  • Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.

Gene Wiki entry for PILRB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PILRB Gene

Genomics for PILRB Gene

Regulatory Elements for PILRB Gene

Enhancers for PILRB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F100482 1.2 ENCODE 44.2 +131.6 131557 1.6 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 ZNF610 PILRA PILRB ZNF655 RN7SL416P RN7SL750P MIR6875 ZSCAN25 EPHB4 PCOLCE AGFG2
GH07F100214 1.2 Ensembl ENCODE 24.5 -132.9 -132874 9.8 HDGF PKNOX1 WRNIP1 YY1 GLIS2 ZNF143 ZNF207 FOS JUNB REST PILRB STAG3L5P PVRIG MBLAC1 AP4M1 GPC2 CNPY4 GIGYF1 PILRA ZCWPW1
GH07F100465 1.1 Ensembl ENCODE 22.4 +114.3 114348 1.9 ELF3 CBX3 ARNT SIN3A ARID4B DMAP1 RAD21 ZNF121 GLIS2 CREM PILRA PILRB C7orf61 TSC22D4
GH07F100269 1 ENCODE 24 -81.2 -81222 3.9 HDGF PKNOX1 CREB3L1 ARID4B SIN3A GLI4 ZNF2 ETS1 ZNF121 ZNF143 PILRB PVRIG MIR6875 EPHB4 PCOLCE STAG3 TRIM56 PLOD3 AP4M1 GATS
GH07F100364 1.3 FANTOM5 ENCODE 9.7 +15.9 15882 6.6 HDGF TBP PKNOX1 ATF1 TBL1XR1 WRNIP1 SIN3A YBX1 BMI1 ZBTB40 PILRA ZCWPW1 MOSPD3 MEPCE LAMTOR4 C7orf43 ENSG00000241357 GIGYF1 GPC2 GAL3ST4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PILRB on UCSC Golden Path with GeneCards custom track

Genomic Location for PILRB Gene

Chromosome:
7
Start:
100,352,176 bp from pter
End:
100,367,831 bp from pter
Size:
15,656 bases
Orientation:
Plus strand

Genomic View for PILRB Gene

Genes around PILRB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PILRB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PILRB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PILRB Gene

Proteins for PILRB Gene

  • Protein details for PILRB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKJ0-PILRB_HUMAN
    Recommended name:
    Paired immunoglobulin-like type 2 receptor beta
    Protein Accession:
    Q9UKJ0
    Secondary Accessions:
    • Q69YF9
    • Q9HBS0

    Protein attributes for PILRB Gene

    Size:
    227 amino acids
    Molecular mass:
    25542 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PILRB Gene

    Alternative splice isoforms for PILRB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PILRB Gene

Post-translational modifications for PILRB Gene

  • Glycosylation at Asn 100
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PILRB Gene

Domains & Families for PILRB Gene

Gene Families for PILRB Gene

Protein Domains for PILRB Gene

Suggested Antigen Peptide Sequences for PILRB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKJ0

UniProtKB/Swiss-Prot:

PILRB_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with PILRB: view

Function for PILRB Gene

Molecular function for PILRB Gene

UniProtKB/Swiss-Prot Function:
Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.

Gene Ontology (GO) - Molecular Function for PILRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10660620
GO:0042288 MHC class I protein binding IBA --
genes like me logo Genes that share ontologies with PILRB: view

Phenotypes for PILRB Gene

GenomeRNAi human phenotypes for PILRB:
genes like me logo Genes that share phenotypes with PILRB: view

Animal Model Products

miRNA for PILRB Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PILRB Gene

Localization for PILRB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PILRB Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PILRB gene
Compartment Confidence
plasma membrane 5
mitochondrion 3
extracellular 2
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PILRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane NAS 10660620
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PILRB: view

Pathways & Interactions for PILRB Gene

SuperPathways for PILRB Gene

No Data Available

Interacting Proteins for PILRB Gene

Gene Ontology (GO) - Biological Process for PILRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS 10660620
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity NAS 10660620
genes like me logo Genes that share ontologies with PILRB: view

No data available for Pathways by source and SIGNOR curated interactions for PILRB Gene

Transcripts for PILRB Gene

Unigene Clusters for PILRB Gene

Paired immunoglobin-like type 2 receptor beta:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PILRB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6: -
SP7: - -

Relevant External Links for PILRB Gene

GeneLoc Exon Structure for
PILRB
ECgene alternative splicing isoforms for
PILRB

Expression for PILRB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PILRB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of PILRB Gene:

PILRB

SOURCE GeneReport for Unigene cluster for PILRB Gene:

Hs.632314
genes like me logo Genes that share expression patterns with PILRB: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PILRB Gene

Orthologs for PILRB Gene

This gene was present in the common ancestor of mammals.

Orthologs for PILRB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PILRB 34 35
  • 97.89 (n)
mouse
(Mus musculus)
Mammalia Pilrb1 34 35
  • 65.2 (n)
Pilrb2 16 35
  • 40 (a)
Pilra 35
  • 31 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC100910801 34
  • 65.13 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 37 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 34 (a)
ManyToMany
PILRA 35
  • 32 (a)
ManyToMany
Species where no ortholog for PILRB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PILRB Gene

ENSEMBL:
Gene Tree for PILRB (if available)
TreeFam:
Gene Tree for PILRB (if available)

Paralogs for PILRB Gene

Paralogs for PILRB Gene

(1) SIMAP similar genes for PILRB Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for PILRB Gene

genes like me logo Genes that share paralogs with PILRB: view

Variants for PILRB Gene

Sequence variations from dbSNP and Humsavar for PILRB Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs111514415 -- 100,362,588(+) ACTGC(A/G)ACTTC intron-variant
rs111526201 -- 100,359,335(+) CTTCC(A/G/T)GCTGT splice-acceptor-variant
rs111877797 -- 100,358,634(+) CCTCT(C/T)TGTGT intron-variant
rs112187450 -- 100,359,761(+) GGCTC(A/G)TGCCT intron-variant
rs112697633 -- 100,359,080(+) CCAGG(C/G)TGAGT splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for PILRB Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
esv2734891 CNV deletion 23290073
nsv428180 CNV gain 18775914
nsv831071 CNV loss 17160897

Variation tolerance for PILRB Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.81; 79.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PILRB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PILRB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PILRB Gene

Disorders for PILRB Gene

Relevant External Links for PILRB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PILRB

No disorders were found for PILRB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PILRB Gene

Publications for PILRB Gene

  1. PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif- bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta. (PMID: 10660620) Mousseau D.D. … Shen S.H. (J. Biol. Chem. 2000) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. PILRI+ and PILRI^ have a siglec fold and provide the basis of binding to sialic acid. (PMID: 24843130) Lu Q. … Gao G.F. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 64

Products for PILRB Gene

Sources for PILRB Gene

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