Aliases for PILRB Gene
External Ids for PILRB Gene
Previous GeneCards Identifiers for PILRB Gene
The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. [provided by RefSeq, Jun 2013]
GeneCards Summary for PILRB Gene
PILRB (Paired Immunoglobin-Like Type 2 Receptor Beta) is a Protein Coding gene. Among its related pathways are B Cell Receptor Signaling Pathway (WikiPathways) and IL-3 Signaling Pathway. An important paralog of this gene is PILRA.
UniProtKB/Swiss-Prot for PILRB Gene
Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.