Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PILRB Gene

Aliases for PILRB Gene

  • Paired Immunoglobin-Like Type 2 Receptor Beta 2 3
  • Activating Receptor PILR-Beta 3 4
  • Cell Surface Receptor FDFACT 3 4
  • Paired Immunoglobulin-Like Type 2 Receptor Beta 3
  • Paired Immunoglobulin-Like Receptor Beta 3
  • Paired Immunoglobin-Like Receptor Beta 3
  • Cell Surface Receptor FDFACT1 3
  • Cell Surface Receptor FDFACT2 3
  • Activating Receptor PILRbeta 3
  • FDFACT1 3
  • FDFACT2 3
  • FDFACT 4

External Ids for PILRB Gene

Previous GeneCards Identifiers for PILRB Gene

  • GC07P099546
  • GC07P099545
  • GC07P099578
  • GC07P099771
  • GC07P099936
  • GC07P099938
  • GC07P094588
  • GC07P099940
  • GC07P099945

Summaries for PILRB Gene

Entrez Gene Summary for PILRB Gene

  • The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. [provided by RefSeq, Jun 2013]

GeneCards Summary for PILRB Gene

PILRB (Paired Immunoglobin-Like Type 2 Receptor Beta) is a Protein Coding gene. Among its related pathways are B Cell Receptor Signaling Pathway (WikiPathways) and IL-3 Signaling Pathway. An important paralog of this gene is PILRA.

UniProtKB/Swiss-Prot for PILRB Gene

  • Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface

Gene Wiki entry for PILRB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PILRB Gene

Genomics for PILRB Gene

Regulatory Elements for PILRB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PILRB Gene

Start:
100,352,176 bp from pter
End:
100,367,831 bp from pter
Size:
15,656 bases
Orientation:
Plus strand

Genomic View for PILRB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PILRB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PILRB Gene

Proteins for PILRB Gene

  • Protein details for PILRB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKJ0-PILRB_HUMAN
    Recommended name:
    Paired immunoglobulin-like type 2 receptor beta
    Protein Accession:
    Q9UKJ0
    Secondary Accessions:
    • Q69YF9
    • Q9HBS0

    Protein attributes for PILRB Gene

    Size:
    227 amino acids
    Molecular mass:
    25542 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PILRB Gene

    Alternative splice isoforms for PILRB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PILRB Gene

Proteomics data for PILRB Gene at MOPED

Post-translational modifications for PILRB Gene

  • Glycosylation at Asn100
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for PILRB Gene

Domains for PILRB Gene

Gene Families for PILRB Gene

HGNC:
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for PILRB Gene

Suggested Antigen Peptide Sequences for PILRB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKJ0

UniProtKB/Swiss-Prot:

PILRB_HUMAN :
  • Q9UKJ0
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with PILRB: view

Function for PILRB Gene

Molecular function for PILRB Gene

UniProtKB/Swiss-Prot Function: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface

Gene Ontology (GO) - Molecular Function for PILRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10660620
genes like me logo Genes that share ontologies with PILRB: view

Phenotypes for PILRB Gene

genes like me logo Genes that share phenotypes with PILRB: view

Animal Models for PILRB Gene

MGI Knock Outs for PILRB:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PILRB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PILRB Gene

Localization for PILRB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PILRB Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PILRB Gene COMPARTMENTS Subcellular localization image for PILRB gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PILRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane NAS 10660620
genes like me logo Genes that share ontologies with PILRB: view

Pathways for PILRB Gene

genes like me logo Genes that share pathways with PILRB: view

Pathways by source for PILRB Gene

2 BioSystems pathways for PILRB Gene

Interacting Proteins for PILRB Gene

Gene Ontology (GO) - Biological Process for PILRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS 10660620
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity NAS 10660620
genes like me logo Genes that share ontologies with PILRB: view

Transcripts for PILRB Gene

Unigene Clusters for PILRB Gene

Paired immunoglobin-like type 2 receptor beta:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PILRB

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PILRB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6: -
SP7: - -

Relevant External Links for PILRB Gene

GeneLoc Exon Structure for
PILRB
ECgene alternative splicing isoforms for
PILRB

Expression for PILRB Gene

mRNA expression in normal human tissues for PILRB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for PILRB Gene Hs.632314

genes like me logo Genes that share expressions with PILRB: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for PILRB Gene

Orthologs for PILRB Gene

This gene was present in the common ancestor of mammals.

Orthologs for PILRB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PILRB 35
  • 97.89 (n)
  • 96.1 (a)
PILRB 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 34 (a)
ManyToMany
PILRA 36
  • 32 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 37 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Pilra 36
  • 31 (a)
ManyToMany
Pilrb1 35
  • 65.2 (n)
  • 50 (a)
Pilrb1 16
Pilrb1 36
  • 38 (a)
ManyToMany
Pilrb2 36
  • 40 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC100910801 35
  • 65.13 (n)
  • 52.31 (a)
Species with no ortholog for PILRB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PILRB Gene

ENSEMBL:
Gene Tree for PILRB (if available)
TreeFam:
Gene Tree for PILRB (if available)

Paralogs for PILRB Gene

Paralogs for PILRB Gene

Selected SIMAP similar genes for PILRB Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for PILRB Gene

genes like me logo Genes that share paralogs with PILRB: view

Variants for PILRB Gene

Sequence variations from dbSNP and Humsavar for PILRB Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
VAR_059406 -
VAR_059407 -

Structural Variations from Database of Genomic Variants (DGV) for PILRB Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
nsv428180 CNV Gain 18775914
nsv888774 CNV Gain 21882294
esv26986 CNV Gain 19812545
esv2734890 CNV Deletion 23290073
nsv436898 CNV Insertion 17901297
nsv8183 CNV Gain+Loss 18304495
nsv831071 CNV Loss 17160897
nsv888775 CNV Loss 21882294
esv270384 CNV Insertion 20981092
esv2734891 CNV Deletion 23290073

Relevant External Links for PILRB Gene

HapMap Linkage Disequilibrium report
PILRB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PILRB Gene

Disorders for PILRB Gene

No disorders were found for PILRB Gene.

No data available for UniProtKB/Swiss-Prot for PILRB Gene

Publications for PILRB Gene

  1. PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif- bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta. (PMID: 10660620) Mousseau D.D. … Shen S.H. (J. Biol. Chem. 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Comparative analysis of the paired immunoglobulin-like receptor (PILR) locus in six mammalian genomes: duplication, conversion, and the birth of new genes. (PMID: 16926269) Wilson M.D. … Koop B.F. (Physiol. Genomics 2006) 3

Products for PILRB Gene

Sources for PILRB Gene

Back to Top

Content