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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PIK3R5 Gene

protein-coding GIFtS: 59
GCID: GC17M008724

phosphoinositide-3-kinase, regulatory subunit 5

Explore 28 diseases affiliated with
PIK3R5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phosphoinositide-3-Kinase, Regulatory Subunit 5¹ ²		F730038I15Rik²
P101-PI3K¹ ²		FOAP-2²
P101¹		Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Regulatory Subunit²
Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Regulatory Subunit² ³		Phosphoinositide 3-Kinase Regulatory Subunit 5²
Protein FOAP-2² ³		P101-PI3K¹ ²
PtdIns-3-Kinase P101² ³		PI3-Kinase Regulatory Subunit 5³
PI3-Kinase P101 Subunit² ³		PtdIns-3-Kinase Regulatory Subunit³

External Ids:	HGNC: 30035¹	Entrez Gene: 23533²	Ensembl: ENSG00000141506⁷	OMIM: 611317⁵	UniProtKB: Q8WYR1³

Export aliases for PIK3R5 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PIK3R5:

Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position,

and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular

trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in

oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric

enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This

protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with

G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been

found. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: PI3R5_HUMAN, Q8WYR1

Function: Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma

membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By

similarity)

summary for PIK3R5:

PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the

3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of

cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell

migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric

consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and

delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst

p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have

recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes

(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI

3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to

play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3R5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PIK3R5 gene promoter:
Elk-1 AML1a Tal-1 AP-4 Tal-1beta E47 PPAR-alpha ZIC2/Zic2 ITF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PIK3R5 promoter sequence

Search SABiosciences Chromatin IP Primers for PIK3R5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIK3R5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1

PIK3R5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIK3R5 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M008724: view genomic region (about GC identifiers)

Start:	8,782,233 bp from pter	End:	8,869,029 bp from pter
Size:	86,797 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PI3R5_HUMAN, Q8WYR1 (See protein sequence)

Recommended Name: Phosphoinositide 3-kinase regulatory subunit 5

Size: 880 amino acids; 97348 Da

Subunit: Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with

beta-gamma G protein dimers

Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By

similarity)

Secondary accessions: B0LPH4 D3DTS3 Q5G936 Q5G938 Q5G939 Q8IZ23 Q9Y2Y2

Alternative splicing: 2 isoforms: Q8WYR1-1 Q8WYR1-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PIK3R5: NX_Q8WYR1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8WYR1

PIK3R5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001136105.1 NP_001238780.1 NP_001238781.1 NP_001238782.1 NP_001238784.1 NP_055123.2

ENSEMBL proteins:

ENSP00000269300 ENSP00000462433 ENSP00000462824 ENSP00000462680 ENSP00000461966

ENSP00000392812

Reactome Protein details: Q8WYR1
Human Recombinant Protein Products:

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	Uscn Proteins for PIK3R5

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	ISS	--
GO:0005829	cytosol	TAS	--
GO:0005942	phosphatidylinositol 3-kinase complex	--	--
GO:0005944	1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex	ISS	--

PIK3R5 for ontologies About GeneDecksing

PIK3R5 Antibody Products:

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	Novus Biologicals PIK3R5 Antibodies
	Search for Antibodies for PIK3R5 at Abcam
	Uscn Antibodies for PIK3R5
	ThermoFisher Antibodies for PIK3R5

Assay Products for PIK3R5:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PIK3R5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PIK3R5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PIK3R5 for domains About GeneDecksing

1 InterPro domain/family:

IPR019522 PI3K_1B_gamma_p101_su

Graphical View of Domain Structure for InterPro Entry Q8WYR1

ProtoNet protein and cluster: Q8WYR1

UniProtKB/Swiss-Prot: PI3R5_HUMAN, Q8WYR1

Domain: The heterodimerization region allows the binding to the catalytic subunit

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PI3R5_HUMAN, Q8WYR1

Function: Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma

membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By

similarity)

Enzyme regulation: Greatly activated by G gamma proteins (By similarity)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): PIK3R5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIK3R5
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		hsa-miR-516b hsa-miR-514 hsa-miR-514b-3p hsa-miR-512-3p
		SwitchGear 3'UTR luciferase reporter plasmid: PIK3R5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PIK3R5 (see all 4) OriGene shRNA RFP: PIK3R5 OriGene siRNA: PIK3R5
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for PIK3R5

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PIK3R5
		Search LifeMap BioReagents cell lines for PIK3R5

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3R5

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0031683	G-protein beta/gamma-subunit complex binding	ISS	--
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	IEA	--

PIK3R5 for ontologies About GeneDecksing

7 GenomeRNAi human phenotypes for PIK3R5:

Decreased cilium length after	Decreased focal adhesion (FA)	Decreased influenza A H1N1 (A/	Decreased influenza A/WSN/33 r
Gemcitabine induced cell-death	Increased circadian period len	Weaker migration

Animal Models:
Mouse knock-out Pik3r5^tm1Lste for PIK3R5
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pik3r5):

cellular

immune system

PIK3R5 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/52 super-pathways (see all 52) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development_A3 receptor signaling

	Development_A3 receptor signaling	1.00			Development_A1 receptor signaling	0.65
	Development A3 receptor signaling	1.00			Development A1 receptor signaling	0.65

Glioma

	Glioma	1.00			Melanoma	0.43
	Non-small cell lung cancer	0.53			Prostate cancer	0.39

mTOR Pathway

	mTOR Pathway	1.00			Insulin Pathway	0.32
	TGF-beta Pathway	0.38

Immune response _CCR3 signaling in eosinophils

	Immune response _CCR3 signaling in eosinophils	1.00			Inhibitory action of Lipoxins on neutrophil migration	0.51
	Immune response CCR3 signaling in eosinophils	1.00

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 EMD Millipore Pathways for PIK3R5 (see all 8)

	Development EDNRB signaling
	Development Beta-adrenergic receptors regulation of ERK
	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
	G-protein signaling G-Protein beta/gamma signaling cascades
	Development A1 receptor signaling

1 Cell Signaling Technology (CST) Pathway for PIK3R5

PI3K / Akt Signaling

5/9 Tocris Bioscience Pathways for PIK3R5 (see all 9)

	Akt Pathway
	Insulin Pathway
	Apoptosis Pathway
	NF-kappaB Pathway
	Toll-like Receptor Pathway

5/11 GeneGo (Thomson Reuters) Pathways for PIK3R5 (see all 11)

	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
	Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
	Development A3 receptor signaling
	Development EDNRB signaling
	Inhibitory action of Lipoxins on neutrophil migration

5/7 BioSystems Pathways for PIK3R5 (see all 7)

	Focal Adhesion
	ErbB signaling pathway
	Toll-like receptor signaling pathway
	Regulation of Actin Cytoskeleton
	Type II diabetes mellitus

5/14 Reactome Pathways for PIK3R5 (see all 14)

	GPCR downstream signaling
	Hemostasis
	Metabolism
	Signaling by GPCR
	Phospholipid metabolism

2 PharmGKB Pathways for PIK3R5

	Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
	Proton Pump Inhibitor Pathway, Pharmacodynamics

5/43 Kegg Pathways (Kegg details for PIK3R5) (see all 43):

	ErbB signaling pathway
	Chemokine signaling pathway
	Phosphatidylinositol signaling system
	mTOR signaling pathway
	Apoptosis

PIK3R5 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PIK3R5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/166 Interacting proteins for PIK3R5 (Q8WYR1³ ENSP00000269300⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 166)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SDHB	P21912³, ENSP00000364649⁴	I2D: score=2 STRING: ENSP00000364649
ADAMTS2	O95450³, ENSP00000251582⁴	I2D: score=1 STRING: ENSP00000251582
PIK3CG	P48736³, ENSP00000352121⁴	I2D: score=3 STRING: ENSP00000352121
CYP4A11	Q02928³, ENSP00000311095⁴	I2D: score=1 STRING: ENSP00000311095
TTR	P02766³, ENSP00000237014⁴	I2D: score=1 STRING: ENSP00000237014

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006644	phospholipid metabolic process	TAS	--
GO:0006661	phosphatidylinositol biosynthetic process	TAS	--
GO:0007186	G-protein coupled receptor signaling pathway	ISS	--
GO:0007596	blood coagulation	TAS	--
GO:0014065	phosphatidylinositol 3-kinase cascade	ISS	--

PIK3R5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for PIK3R5:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for PIK3R5 available from Tocris Bioscience About this table

Compound	Action	CAS #
LY 294002 hydrochloride	Selective PI 3-kinase inhibitor	[154447-36-6]
Quercetin	Non-selective PI 3-kinase inhibitor	[117-39-5]
PI 103 hydrochloride	Inhibitor of PI 3-kinase, mTOR and DNA-PK	[371935-74-9]
BAG 956	Dual PI 3-kinase and PDK1 inhibitor	[853910-02-8]
PI 828	PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130)	[942289-87-4]

Search CenterWatch for drugs/clinical trials and news about PIK3R5 / PI3R5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PIK3R5 gene (6 alternative transcripts):

NM_001142633.2 NM_001251851.1 NM_001251852.1 NM_001251853.1 NM_001251855.1 NM_014308.3

Unigene Clusters for PIK3R5:

Phosphoinositide-3-kinase, regulatory subunit 5

Hs.278901 [show with all ESTs], Hs.738684

Unigene Representative Sequences: NM_001251851, AK129627

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000269300 ENST00000581552 ENST00000585260 ENST00000583810 ENST00000584803

ENST00000578515 ENST00000578743 ENST00000577214 ENST00000583039 ENST00000584456

ENST00000578457 ENST00000580959 ENST00000583812 ENST00000577981 ENST00000581895

ENST00000583222 ENST00000447110(uc002glt.3 uc010vuz.2 uc021tqc.1 uc010cob.2 uc010coa.2 uc002glu.4)

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		hsa-miR-516b hsa-miR-514 hsa-miR-514b-3p hsa-miR-512-3p
		SwitchGear 3'UTR luciferase reporter plasmid: PIK3R5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence: AK129627.1

8 DOTS entries:

DT.40228263 DT.413468 DT.120915088 DT.91916131 DT.120915086 DT.97809619 DT.97826869 DT.99959317

24/94 AceView cDNA sequences (see all 94):

BE042519 AI299749 AW188135 AW572143 AF128881 NM_014308 BG231785 BQ012026

CD370815 BG236366 AA868047 CD743007 CB045516 AI224130 BX415964 BQ706151

BE219115 AI298753 CD742744 BU626695 AB028925 BU859135 BQ011125 H79281

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for PIK3R5 (see all 9) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17a	·	17b	·	17c	^	18	^	19	^	20a	·	20b	·	20c
SP1:									-
SP2:									-										-
SP3:									-						-				-
SP4:																			-
SP5:																																					-

ECgene alternative splicing isoforms for PIK3R5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PIK3R5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCATAACCAG

About this image

PIK3R5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Definitive endoderm-like cells (Generation and expan...)

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PIK3R5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PIK3R5

SOURCE GeneReport for Unigene clusters: Hs.278901 Hs.738684

UniProtKB/Swiss-Prot: PI3R5_HUMAN, Q8WYR1

Tissue specificity: Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant

expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli

SABiosciences Expression via Pathway-Focused PCR Array including PIK3R5:

VEGF Signaling in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for PIK3R5 gene from 5/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pik3r5^{1 , 5}	phosphoinositide-3-kinase, regulatory subunit 5, p1 more^{1, 5}	84.85(n)¹ 87.03(a)¹		11 (41.69 cM)⁵ 320207¹ NM_177320.2¹ NP_796294.2¹ 68432121⁵
chicken (Gallus gallus)	Aves	PIK3R5¹	phosphoinositide 3-kinase regulatory subunit 5	67.44(n) 63.59(a)		417319 NM_001030697.1 NP_001025868.1
lizard (Anolis carolinensis)	Reptilia	PIK3R5⁶	--	60(a)	1 ↔ 1	2(105265992-105293229)
African clawed frog (Xenopus laevis)	Amphibia	Xl.2361²	Xenopus laevis transcribed sequence with weak similarity more	77.21(n)		BQ399922.1
zebrafish (Danio rerio)	Actinopterygii	pik3r5¹	phosphoinositide-3-kinase, regulatory subunit 5	54.33(n) 48.47(a)		323588 XM_002662345.1 XP_002662391.1

ENSEMBL Gene Tree for PIK3R5 (if available)
TreeFam Gene Tree for PIK3R5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs144629073^1,2	C	other	8689685(+)	`TCAGGG/AGGCAG`	12	/P	syn¹		1		NA	4540
rs73973253^1,2	C,	--	8681052(+)	`CTAAAG/CGCAGT`	6	--	ds500¹		2		WA	120
rs61761143^1,2	C,F,	--	8681213(-)	`GAAATA/GTATAC`	6	--	ds500¹		3		NS WA	202
rs61761141^1,2	C,	--	8681299(-)	`GCCTCA/GTCATA`	6	--	ds500¹		2		NS	84
rs112805290^1,2	C,	--	8681327(+)	`GGGGAA/GAATTT`	6	--	ds500¹		0	--	--	--	--
rs7342822^1,2	C,F,A,H,	--	8681864(+)	`TCTAGC/TCCATG`	6	--	ut3¹ ese³		13		NS EA NA WA CSA	1302
rs61761140^1,2	C,F,	--	8682085(-)	`CTCTGC/TGTGTA`	6	--	ut3¹		5		NS WA CSA	214
rs61761139^1,2	C,F,	--	8682973(-)	`TTCCTG/CGCAGT`	6	--	ut3¹		4		NS CSA WA	214
rs61761138^1,2	C,F,	--	8683070(-)	`GAGCAG/AGGGCT`	6	--	ut3¹		4		NS CSA WA	210
rs61761135^1,2	C,F,	--	8683826(-)	`NNNNCA/GGGCAG`	6	--	int¹		4		NS NA	214

HapMap Linkage Disequilibrium report for PIK3R5 (8782233 - 8869029 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PIK3R5: --
Human Gene Mutation Database (HGMD): PIK3R5

1 SABiosciences Cancer Mutation PCR Assay for PIK3R5:

Cosmic Id	AA Change
33390	p.R28C

2 SABiosciences Cancer Mutation PCR Arrays containing PIK3R5:

PI3K-PTEN Pathway

Cancer Comprehensive Panel 384HT

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PIK3R5

DNA2.0 Custom Variant and Variant Library Synthesis for PIK3R5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PIK3R5 for disorders About GeneDecksing

OMIM gene information: 611317 OMIM disorders: --

UniProtKB/Swiss-Prot: PI3R5_HUMAN, Q8WYR1

Note=Defects in PIK3R5 may be a cause of autosomal recessive ataxia with oculomotor apraxia (AOA). A PIK3R5

mutation segregates with the disease phenotype in a family affected by gait ataxia, cerebellar dysarthric speech, and

impaired ocular movement. Additional features include reduced or absent tendon reflexes, severe cerebellar atrophy,

marked vermal atrophy, moderately severe axonal sensory polyneuropathy with absent sensory nerve action potential in

the lower extremities, and persistently elevated alpha-fetoprotein levels

20/28 diseases for PIK3R5 (see all 28): About MalaCards

myeloid leukemia chronic myeloid leukemia acute myeloid leukemia apraxia

renal cell carcinoma cblc chagas disease hepatitis c

trypanosomiasis toxoplasmosis measles aldosteronism

endometrial cancer leukemia influenza pancreatic cancer

colorectal cancer lung cancer prostate cancer pancreatitis

2 diseases from the University of Copenhagen DISEASES database for PIK3R5:

Apraxia DOID:4019

Human Genome Epidemiology (HuGE) Navigator: PIK3R5 (5 documents)

Export disorders for PIK3R5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PIK3R5 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with PIK3R5)

Utopia: connect your pdf to the dynamic
world of online information

A missense mutation in PIK3R5 gene in a family with ataxia and oculomotor apraxia. (PubMed id 22065524)^{1, 2} Tassan N.A.... Bohlega S. (2012)
p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma. (PubMed id 15797027)^{1, 2} Suire S....Stephens L. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma. (PubMed id 12507995)^{1, 3} Brock C....Nurnberg B. (2003)
Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)¹ Lin Y.Y....Boeke J.D. (2012)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)¹ Segat L....Crovella S. (2010)
Phosphatidylinositol 3-kinase: the oncoprotein. (PubMed id 20582532)¹ Vogt P.K....Denley A. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23533	HGNC: 30035	AceView: P101-PI3K	Ensembl:ENSG00000141506	euGenes: HUgn23533
ECgene: PIK3R5	Kegg: 23533	H-InvDB: PIK3R5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PIK3R5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PIK3R5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PIK3R5 gene:
Search GeneIP for patents involving PIK3R5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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phosphoinositide-3-kinase, regulatory subunit 5

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PIK3R5 Gene

phosphoinositide-3-kinase, regulatory subunit 5

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