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Aliases for PIK3R5 Gene

Aliases for PIK3R5 Gene

  • Phosphoinositide-3-Kinase, Regulatory Subunit 5 2 3
  • Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Regulatory Subunit 3 4
  • PI3-Kinase P101 Subunit 3 4
  • PtdIns-3-Kinase P101 3 4
  • Protein FOAP-2 3 4
  • P101-PI3K 3 4
  • P101 3 6
  • Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Regulatory Subunit 3
  • Phosphoinositide 3-Kinase Regulatory Subunit 5 3
  • PtdIns-3-Kinase Regulatory Subunit 4
  • PI3-Kinase Regulatory Subunit 5 4
  • F730038I15Rik 3
  • FOAP-2 3

External Ids for PIK3R5 Gene

Summaries for PIK3R5 Gene

Entrez Gene Summary for PIK3R5 Gene

  • Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]

GeneCards Summary for PIK3R5 Gene

PIK3R5 (Phosphoinositide-3-Kinase, Regulatory Subunit 5) is a Protein Coding gene. Diseases associated with PIK3R5 include ataxia-oculomotor apraxia 3 and ataxia-ocular apraxia-2. Among its related pathways are PI3K-Akt signaling pathway and Glioma. GO annotations related to this gene include G-protein beta/gamma-subunit complex binding and 1-phosphatidylinositol-3-kinase regulator activity.

UniProtKB/Swiss-Prot for PIK3R5 Gene

  • Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity).

Tocris Summary for PIK3R5 Gene

  • PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the 3OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes (C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI 3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3R5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIK3R5 Gene

Genomics for PIK3R5 Gene

Genomic Location for PIK3R5 Gene

Start:
8,878,911 bp from pter
End:
8,965,712 bp from pter
Size:
86,802 bases
Orientation:
Minus strand

Genomic View for PIK3R5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIK3R5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIK3R5 Gene

Regulatory Elements for PIK3R5 Gene

Proteins for PIK3R5 Gene

  • Protein details for PIK3R5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WYR1-PI3R5_HUMAN
    Recommended name:
    Phosphoinositide 3-kinase regulatory subunit 5
    Protein Accession:
    Q8WYR1
    Secondary Accessions:
    • B0LPH4
    • D3DTS3
    • Q5G936
    • Q5G938
    • Q5G939
    • Q8IZ23
    • Q9Y2Y2

    Protein attributes for PIK3R5 Gene

    Size:
    880 amino acids
    Molecular mass:
    97348 Da
    Quaternary structure:
    • Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with beta-gamma G protein dimers.

    Alternative splice isoforms for PIK3R5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIK3R5 Gene

Proteomics data for PIK3R5 Gene at MOPED

Post-translational modifications for PIK3R5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys429

No data available for DME Specific Peptides for PIK3R5 Gene

Domains for PIK3R5 Gene

Protein Domains for PIK3R5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PIK3R5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WYR1

UniProtKB/Swiss-Prot:

PI3R5_HUMAN
Domain:
  • The heterodimerization region allows the binding to the catalytic subunit:
    • Q8WYR1
genes like me logo Genes that share domains with PIK3R5: view

No data available for Gene Families for PIK3R5 Gene

Function for PIK3R5 Gene

Molecular function for PIK3R5 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Greatly activated by G gamma proteins.
UniProtKB/Swiss-Prot Function: Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity).

Gene Ontology (GO) - Molecular Function for PIK3R5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031683 G-protein beta/gamma-subunit complex binding ISS --
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity IEA --
genes like me logo Genes that share ontologies with PIK3R5: view
genes like me logo Genes that share phenotypes with PIK3R5: view

Animal Models for PIK3R5 Gene

MGI Knock Outs for PIK3R5:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PIK3R5 Gene

Localization for PIK3R5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIK3R5 Gene

Nucleus. Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIK3R5 Gene COMPARTMENTS Subcellular localization image for PIK3R5 gene
Compartment Confidence
cytosol 4
nucleus 3
extracellular 1

Gene Ontology (GO) - Cellular Components for PIK3R5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
GO:0005942 phosphatidylinositol 3-kinase complex --
GO:0005944 phosphatidylinositol 3-kinase complex, class IB ISS --
genes like me logo Genes that share ontologies with PIK3R5: view

Pathways for PIK3R5 Gene

genes like me logo Genes that share pathways with PIK3R5: view

Gene Ontology (GO) - Biological Process for PIK3R5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0007186 G-protein coupled receptor signaling pathway ISS --
GO:0007596 blood coagulation TAS --
GO:0008219 cell death --
genes like me logo Genes that share ontologies with PIK3R5: view

Compounds for PIK3R5 Gene

(28) ApexBio Compounds for PIK3R5 Gene

Compound Action Cas Number
A66 highly specific and selective p110alpha inhibitor [1166227-08-2]
AS-605240 Potent and selective inhibitor of PI 3-kinase beta.[648450-29-7] http://www.apexbt.com/search.php?catalog=A5176
AZD6482 Potent and selective inhibitor of PI 3-kinase beta. [1173900-33-8]
BEZ235 (NVP-BEZ235) imidazoquinoline derivative inhibiting both PI3K and mTOR kinases [915019-65-7]
BKM120 small-molecule inhibitor of pan-Class I PI3K [944396-07-0]
BYL-719 selective PI3Kalfa inhibitor [1217486-61-7]
CAL-101 (Idelalisib, GS-1101) p110delta selective PI3K inhibitor [870281-82-6]
CAL-130 novel PI3K inhibitor. [1431697-74-3]
CUDC-907 dual PI3K and HDAC inhibitor [1339928-25-4]
CZC24832 selective inhibitor of PI3Kgamma [1159824-67-5]
GDC-0941 PI3K inhibitor. [957054-30-7]
IC-87114 selectively inhibits PI3Ksigma [371242-69-2]
IPI-145 (INK1197) orally bioavailable, highly selective and potent small molecule inhibitor of PI3K [1201438-56-3]
LY 294002 selective PI3K inhibitor with a 2.7-fold greater potency than quercetin. [154447-36-6]
NVP-BGT226 suppresses the activation of the AKT/FRAP(mTOR) signal cascade. [1245537-68-1]
PF-04691502 potent and selective dual PI3K/mTOR (FRAP) inhibitor [1013101-36-4]
PI-103 potent inhibitor against recombinant PI3K [371935-74-9]
PIK-75 blocks production of PIP2 and/or PIP3 [372196-77-5]
PIK-90 selectively inhibits different subsets of four class I PI3K [677338-12-4]
PIK-93 novel and potent inhibitor of both PI3Kgamma and PI4KIIIbeta [593960-11-3]
PKI-402 selective, reversible, ATP-competitive, equipotent class I PI3K inhibitor [1173204-81-3]
SAR245409 (XL765) active against class I PI3K. [1349796-36-6]
TG100-115 inhibits PI3Kgamma and -delta [677297-51-7]
TGX-221 [663619-89-4]
VS-5584 (SB2343) all class I PI3K isoforms [1246560-33-7]
XL147 ATP-competitive inhibitor of class I PI3K isoforms. [956958-53-5]
XL765 mixed mTOR/PI3k inhibitor [1123889-87-1]
ZSTK474 binds to the ATP-binding site of Class PI3K and inhibits PI3K activity. [475110-96-4]

(5) Tocris Compounds for PIK3R5 Gene

Compound Action Cas Number
740 Y-P Cell-permeable PI 3-kinase activator [1236188-16-1]
AS 605240 Potent and selective PI 3-kinase gamma (PI3Kgamma) inhibitor [648450-29-7]
CZC 24832 Selective inhibitor of PI 3-Kinase gamma [1159824-67-5]
PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK [371935-74-9]
Quercetin Non-selective PI 3-kinase inhibitor [117-39-5]
genes like me logo Genes that share compounds with PIK3R5: view

Transcripts for PIK3R5 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PIK3R5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20a · 20b · 20c
SP1: -
SP2: - -
SP3: - - -
SP4: -
SP5: -
SP6: -
SP7:
SP8:
SP9:

Relevant External Links for PIK3R5 Gene

GeneLoc Exon Structure for
PIK3R5
ECgene alternative splicing isoforms for
PIK3R5

Expression for PIK3R5 Gene

mRNA expression in normal human tissues for PIK3R5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIK3R5 Gene

This gene is overexpressed in Whole Blood (22.8) and Spleen (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PIK3R5 Gene

SOURCE GeneReport for Unigene cluster for PIK3R5 Gene Hs.278901

mRNA Expression by UniProt/SwissProt for PIK3R5 Gene

Q8WYR1-PI3R5_HUMAN
Tissue specificity: Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli.
genes like me logo Genes that share expressions with PIK3R5: view

Orthologs for PIK3R5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PIK3R5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIK3R5 35
  • 99.36 (n)
  • 99.66 (a)
PIK3R5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PIK3R5 35
  • 87.1 (n)
  • 88.67 (a)
PIK3R5 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIK3R5 35
  • 88.52 (n)
  • 91.53 (a)
PIK3R5 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pik3r5 35
  • 84.69 (n)
  • 86.68 (a)
Pik3r5 16
Pik3r5 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIK3R5 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIK3R5 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pik3r5 35
  • 84.75 (n)
  • 86.81 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 60 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
PIK3R5 35
  • 68 (n)
  • 65.33 (a)
PIK3R5 36
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia PIK3R5 36
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2361 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pik3r5 35
  • 60.9 (n)
  • 53.92 (a)
Str.19584 35
zebrafish
(Danio rerio)
Actinopterygii pik3r5 35
  • 53.76 (n)
  • 49.17 (a)
pik3r5 36
  • 45 (a)
OneToOne
Species with no ortholog for PIK3R5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PIK3R5 Gene

ENSEMBL:
Gene Tree for PIK3R5 (if available)
TreeFam:
Gene Tree for PIK3R5 (if available)

Paralogs for PIK3R5 Gene

No data available for Paralogs for PIK3R5 Gene

Variants for PIK3R5 Gene

Sequence variations from dbSNP and Humsavar for PIK3R5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs14681 -- 8,879,094(+) GAGAC(G/T)GCCAG utr-variant-3-prime
rs25598 -- 8,882,879(+) CCTAA(-/TTTCT)CTTCT intron-variant
rs92535 -- 8,905,758(-) CATTC(C/T)CCTTC intron-variant
rs103033 -- 8,889,870(-) CACAG(G/T)CACTC intron-variant
rs181530 -- 8,905,216(+) TGTTA(C/T)GGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIK3R5 Gene

Variant ID Type Subtype PubMed ID
nsv1970 CNV Loss 18451855
nsv510696 CNV Loss 20534489
esv2715621 CNV Deletion 23290073
esv2282824 CNV Deletion 18987734
esv2715622 CNV Deletion 23290073
esv2715623 CNV Deletion 23290073
nsv827881 CNV Loss 20364138
esv259863 OTHER Complex 20981092
nsv833354 CNV Loss 17160897
esv2658276 CNV Deletion 23128226

Relevant External Links for PIK3R5 Gene

HapMap Linkage Disequilibrium report
PIK3R5
Human Gene Mutation Database (HGMD)
PIK3R5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIK3R5 Gene

Disorders for PIK3R5 Gene

(1) OMIM Diseases for PIK3R5 Gene (611317)

UniProtKB/Swiss-Prot

PI3R5_HUMAN
  • Ataxia-oculomotor apraxia 3 (AOA3) [MIM:615217]: An autosomal recessive disease characterized by cerebellar ataxia, oculomotor apraxia, areflexia and peripheral neuropathy. {ECO:0000269 PubMed:22065524}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for PIK3R5 Gene

Relevant External Links for PIK3R5

Genetic Association Database (GAD)
PIK3R5
Human Genome Epidemiology (HuGE) Navigator
PIK3R5
genes like me logo Genes that share disorders with PIK3R5: view

Publications for PIK3R5 Gene

  1. p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma. (PMID: 15797027) Suire S. … Stephens L. (Curr. Biol. 2005) 3 4
  2. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 48
  3. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L. … Crovella S. (Vaccine 2010) 3 48
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. A missense mutation in PIK3R5 gene in a family with ataxia and oculomotor apraxia. (PMID: 22065524) Tassan N.A. … Bohlega S. (Hum. Mutat. 2012) 3 4

Products for PIK3R5 Gene

Sources for PIK3R5 Gene

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