Aliases for PIK3R4 Gene
External Ids for PIK3R4 Gene
Previous GeneCards Identifiers for PIK3R4 Gene
GeneCards Summary for PIK3R4 Gene
PIK3R4 (Phosphoinositide-3-Kinase Regulatory Subunit 4) is a Protein Coding gene. Among its related pathways are CTLA4 Signaling and p70S6K Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and binding.
UniProtKB/Swiss-Prot for PIK3R4 Gene
Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123).
PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.