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Aliases for PIK3R3 Gene

Aliases for PIK3R3 Gene

  • Phosphoinositide-3-Kinase, Regulatory Subunit 3 (Gamma) 2 3
  • Phosphatidylinositol 3-Kinase 55 KDa Regulatory Subunit Gamma 3 4
  • PtdIns-3-Kinase Regulatory Subunit P55-Gamma 3 4
  • PI3-Kinase Regulatory Subunit Gamma 3 4
  • PI3K Regulatory Subunit Gamma 3 4
  • PI3-Kinase Subunit P55-Gamma 3 4
  • P55PIK 3 4
  • Phosphatidylinositol 3-Kinase, Regulatory Subunit, Polypeptide 3 (P55, Gamma) 3
  • Phosphoinositide-3-Kinase, Regulatory Subunit, Polypeptide 3 (P55, Gamma) 3
  • Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma 3
  • PtdIns-3-Kinase Regulatory Subunit Gamma 4
  • P55-GAMMA 3
  • P55 3

External Ids for PIK3R3 Gene

Previous GeneCards Identifiers for PIK3R3 Gene

  • GC01M046199
  • GC01M045462
  • GC01M045892
  • GC01M045875
  • GC01M046217
  • GC01M046505
  • GC01M044621

Summaries for PIK3R3 Gene

GeneCards Summary for PIK3R3 Gene

PIK3R3 (Phosphoinositide-3-Kinase, Regulatory Subunit 3 (Gamma)) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include 1-phosphatidylinositol-3-kinase activity and phosphatidylinositol 3-kinase regulator activity. An important paralog of this gene is PIK3R1.

UniProtKB/Swiss-Prot for PIK3R3 Gene

  • Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1

Tocris Summary for PIK3R3 Gene

  • PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes (C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI 3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3R3 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIK3R3 Gene

Genomics for PIK3R3 Gene

Regulatory Elements for PIK3R3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PIK3R3 Gene

46,040,140 bp from pter
46,133,036 bp from pter
92,897 bases
Minus strand

Genomic View for PIK3R3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIK3R3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIK3R3 Gene

Proteins for PIK3R3 Gene

  • Protein details for PIK3R3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphatidylinositol 3-kinase regulatory subunit gamma
    Protein Accession:
    Secondary Accessions:
    • B2R9C1
    • D3DQ12
    • O60482
    • Q5T4P1
    • Q5T4P2

    Protein attributes for PIK3R3 Gene

    461 amino acids
    Molecular mass:
    54448 Da
    Quaternary structure:
    • Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL.

    Alternative splice isoforms for PIK3R3 Gene


neXtProt entry for PIK3R3 Gene

Proteomics data for PIK3R3 Gene at MOPED

Post-translational modifications for PIK3R3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIK3R3 Gene

Antibody Products

  • R&D Systems Antibodies for PIK3R3 (PI 3-Kinase p55 gamma)
  • Cell Signaling Technology (CST) Antibodies for PIK3R3 (PIK3R3)

No data available for DME Specific Peptides for PIK3R3 Gene

Domains for PIK3R3 Gene

Gene Families for PIK3R3 Gene

  • SH2D :SH2 domain containing

Protein Domains for PIK3R3 Gene

Suggested Antigen Peptide Sequences for PIK3R3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q92569
  • Contains 2 SH2 domains.
  • Belongs to the PI3K p85 subunit family.
genes like me logo Genes that share domains with PIK3R3: view

Function for PIK3R3 Gene

Molecular function for PIK3R3 Gene

UniProtKB/Swiss-Prot Function: Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1

Gene Ontology (GO) - Molecular Function for PIK3R3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16273093
GO:0016303 1-phosphatidylinositol-3-kinase activity TAS 9524259
GO:0035014 phosphatidylinositol 3-kinase regulator activity --
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity IBA --
genes like me logo Genes that share ontologies with PIK3R3: view
genes like me logo Genes that share phenotypes with PIK3R3: view

miRNA for PIK3R3 Gene

miRTarBase miRNAs that target PIK3R3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIK3R3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PIK3R3 Gene

Localization for PIK3R3 Gene

Subcellular locations from

Jensen Localization Image for PIK3R3 Gene COMPARTMENTS Subcellular localization image for PIK3R3 gene
Compartment Confidence
cytosol 4
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PIK3R3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005942 phosphatidylinositol 3-kinase complex IBA --
genes like me logo Genes that share ontologies with PIK3R3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PIK3R3 Gene

Pathways for PIK3R3 Gene

SuperPathways for PIK3R3 Gene

Superpath Contained pathways
1 PI-3K cascade
2 Signaling by FGFR
3 IL-2 Pathway
4 IL-9 Signaling Pathways
5 Apoptotic Pathways in Synovial Fibroblasts
genes like me logo Genes that share pathways with PIK3R3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PIK3R3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0008286 insulin receptor signaling pathway TAS 9524259
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process TAS 9524259
GO:0043551 regulation of phosphatidylinositol 3-kinase activity IBA --
genes like me logo Genes that share ontologies with PIK3R3: view

Compounds for PIK3R3 Gene

(5) Tocris Compounds for PIK3R3 Gene

Compound Action Cas Number
740 Y-P Cell-permeable PI 3-kinase activator [1236188-16-1]
PF 05212384 Potent and selective dual PI 3-K/mTOR inhibitor [1197160-78-3]
PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK [371935-79-4]
PI 828 PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130) [942289-87-4]
Quercetin Non-selective PI 3-kinase inhibitor [117-39-5]

(28) ApexBio Compounds for PIK3R3 Gene

Compound Action Cas Number
A66 highly specific and selective p110alpha inhibitor [1166227-08-2]
AS-605240 Potent and selective inhibitor of PI 3-kinase beta.[648450-29-7]
AZD6482 Potent and selective inhibitor of PI 3-kinase beta. [1173900-33-8]
BEZ235 (NVP-BEZ235) imidazoquinoline derivative inhibiting both PI3K and mTOR kinases [915019-65-7]
BKM120 small-molecule inhibitor of pan-Class I PI3K [944396-07-0]
BYL-719 selective PI3Kalfa inhibitor [1217486-61-7]
CAL-101 (Idelalisib, GS-1101) p110delta selective PI3K inhibitor [870281-82-6]
CAL-130 novel PI3K inhibitor. [1431697-74-3]
CUDC-907 dual PI3K and HDAC inhibitor [1339928-25-4]
CZC24832 selective inhibitor of PI3Kgamma [1159824-67-5]
GDC-0941 PI3K inhibitor. [957054-30-7]
IC-87114 selectively inhibits PI3Ksigma [371242-69-2]
IPI-145 (INK1197) orally bioavailable, highly selective and potent small molecule inhibitor of PI3K [1201438-56-3]
LY 294002 selective PI3K inhibitor with a 2.7-fold greater potency than quercetin. [154447-36-6]
NVP-BGT226 suppresses the activation of the AKT/FRAP(mTOR) signal cascade. [1245537-68-1]
PF-04691502 potent and selective dual PI3K/mTOR (FRAP) inhibitor [1013101-36-4]
PI-103 potent inhibitor against recombinant PI3K [371935-74-9]
PIK-75 blocks production of PIP2 and/or PIP3 [372196-77-5]
PIK-90 selectively inhibits different subsets of four class I PI3K [677338-12-4]
PIK-93 novel and potent inhibitor of both PI3Kgamma and PI4KIIIbeta [593960-11-3]
PKI-402 selective, reversible, ATP-competitive, equipotent class I PI3K inhibitor [1173204-81-3]
SAR245409 (XL765) active against class I PI3K. [1349796-36-6]
TG100-115 inhibits PI3Kgamma and -delta [677297-51-7]
TGX-221 [663619-89-4]
VS-5584 (SB2343) all class I PI3K isoforms [1246560-33-7]
XL147 ATP-competitive inhibitor of class I PI3K isoforms. [956958-53-5]
XL765 mixed mTOR/PI3k inhibitor [1123889-87-1]
ZSTK474 binds to the ATP-binding site of Class PI3K and inhibits PI3K activity. [475110-96-4]

(1) Drugbank Compounds for PIK3R3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • Epinephrine Isopropyl Homolog
7683-59-2 target agonist

(3) Novoseek inferred chemical compound relationships for PIK3R3 Gene

Compound -log(P) Hits PubMed IDs
phosphatidylinositol 73.6 17
phosphoinositide 54.2 3
tyrosine 11.9 2
genes like me logo Genes that share compounds with PIK3R3: view

Transcripts for PIK3R3 Gene

Unigene Clusters for PIK3R3 Gene

Phosphoinositide-3-kinase, regulatory subunit 3 (gamma):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIK3R3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIK3R3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a ·
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - -
SP8: - -

ExUns: 13b ^ 14a · 14b · 14c

Relevant External Links for PIK3R3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PIK3R3 Gene

mRNA expression in normal human tissues for PIK3R3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PIK3R3 Gene

SOURCE GeneReport for Unigene cluster for PIK3R3 Gene Hs.655387

mRNA Expression by UniProt/SwissProt for PIK3R3 Gene

Tissue specificity: Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle
genes like me logo Genes that share expressions with PIK3R3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PIK3R3 Gene

Orthologs for PIK3R3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PIK3R3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PIK3R3 35
  • 99.78 (n)
  • 99.78 (a)
PIK3R3 36
  • 100 (a)
(Bos Taurus)
Mammalia PIK3R3 35
  • 93.78 (n)
  • 97.18 (a)
PIK3R3 36
  • 98 (a)
(Canis familiaris)
Mammalia PIK3R3 35
  • 94.96 (n)
  • 98.56 (a)
PIK3R3 36
  • 99 (a)
(Mus musculus)
Mammalia Pik3r3 35
  • 91.83 (n)
  • 95.88 (a)
Pik3r3 16
Pik3r3 36
  • 96 (a)
(Monodelphis domestica)
Mammalia PIK3R3 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia PIK3R3 36
  • 89 (a)
(Rattus norvegicus)
Mammalia Pik3r3 35
  • 90.89 (n)
  • 94.79 (a)
(Gallus gallus)
Aves PIK3R3 35
  • 83.61 (n)
  • 91.61 (a)
PIK3R3 36
  • 55 (a)
(Anolis carolinensis)
Reptilia PIK3R3 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pik3r3 35
  • 80.55 (n)
  • 88.94 (a)
Str.7110 35
(Danio rerio)
Actinopterygii pik3r3b 35
  • 75.05 (n)
  • 86.55 (a)
pik3r3b 36
  • 86 (a)
zgc55564 35
fruit fly
(Drosophila melanogaster)
Insecta Pi3K21B 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea aap-1 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 2 (a)
Species with no ortholog for PIK3R3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIK3R3 Gene

Gene Tree for PIK3R3 (if available)
Gene Tree for PIK3R3 (if available)

Paralogs for PIK3R3 Gene

Paralogs for PIK3R3 Gene

Selected SIMAP similar genes for PIK3R3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PIK3R3: view

Variants for PIK3R3 Gene

Sequence variations from dbSNP and Humsavar for PIK3R3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs785462 -- 46,060,079(-) tctgt(C/T)gccca intron-variant
rs785463 -- 46,058,562(-) gctga(C/T)gcaag intron-variant
rs785464 -- 46,057,417(-) tcccc(A/G)ttttc intron-variant
rs785465 -- 46,056,905(-) tcaga(G/T)gtagg intron-variant
rs785466 -- 46,056,120(-) tgagc(C/T)gagat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIK3R3 Gene

Variant ID Type Subtype PubMed ID
nsv871928 CNV Gain 21882294
nsv829737 CNV Gain 17160897
nsv508012 CNV Loss 20534489

Relevant External Links for PIK3R3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIK3R3 Gene

Disorders for PIK3R3 Gene

Relevant External Links for PIK3R3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PIK3R3: view

No data available for UniProtKB/Swiss-Prot for PIK3R3 Gene

Publications for PIK3R3 Gene

  1. Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor. (PMID: 9524259) Dey B.R. … Nissley S.P. (Gene 1998) 2 3 4
  2. Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin. (PMID: 12470648) Hafizi S. … Dahlbaeck B. (Biochem. Biophys. Res. Commun. 2002) 3 4
  3. Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer. (PMID: 20197460) Koutros S. … Berndt S.I. (Cancer Res. 2010) 3 48
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma. (PMID: 17360667) Soroceanu L. … Phillips H.S. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 23

Products for PIK3R3 Gene

Sources for PIK3R3 Gene

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