PIK3R3 Gene
protein-coding GIFtS: 63
GCID: GC01M046505
|
|
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
| |
Aliases
for PIK3R3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Phosphoinositide-3-Kinase, Regulatory Subunit 3 (Gamma)1 2 | | PI3K Regulatory Subunit Gamma2 3 | | P551 | | 100% Homology To SWISS-PROT Q925692 | | Phosphatidylinositol 3-Kinase 55 KDa Regulatory Subunit Gamma2 3 | | P55-GAMMA1 | | PtdIns-3-Kinase Regulatory Subunit Gamma2 3 | | Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma2 | | PtdIns-3-Kinase Regulatory Subunit P55-Gamma2 3 | | Phosphatidylinositol 3-Kinase, Regulatory Subunit, Polypeptide 3 (P55, Gamma)2 | | P55PIK1 | | Phosphoinositide-3-Kinase, Regulatory Subunit 3 (P55, Gamma)2 | | PI3-Kinase Regulatory Subunit Gamma2 3 | | Phosphoinositide-3-Kinase, Regulatory Subunit, Polypeptide 3 (P55, Gamma)2 | | PI3-Kinase Subunit P55-Gamma2 3 | | |
Export aliases for PIK3R3 gene to outside databasesPrevious GC identifers: GC01M046199 GC01M045462 GC01M045892 GC01M045875 GC01M046217 GC01M044621 |
Summaries
for PIK3R3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: P55G_HUMAN, Q92569Function: Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates theirkinase activity. During insulin stimulation, it also binds to IRS-1
 summary
for PIK3R3: PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the
3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of
cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell
migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric
consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and
delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst
p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have
recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes
(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI
3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to
play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.
Gene Wiki entry for PIK3R3
|
Genomic Views
for PIK3R3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PIK3R3 gene promoter:
Pax-5 Cart-1 c-Myb Nkx2-5 Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for PIK3R3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIK3R3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p34.1 Ensembl cytogenetic band: 1p34.1 HGNC cytogenetic band: 1p34.1PIK3R3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M046505: view genomic region
(about GC identifiers)
Start:
|
46,505,812 bp from pter |
End:
|
46,642,160 bp from pter |
Size:
|
136,349 bases |
Orientation:
|
minus strand |
|
Proteins
for PIK3R3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: P55G_HUMAN, Q92569 (See
protein sequence)Recommended Name: Phosphatidylinositol 3-kinase regulatory subunit gamma Size: 461 amino acids; 54448 Da
Subunit: Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interactswith AXL
Secondary accessions: B2R9C1 D3DQ12 O60482 Q5T4P1 Q5T4P2Alternative splicing: 3 isoforms: Q92569-1 Q92569-2 Q92569-3 Explore the universe of human proteins at neXtProt for PIK3R3: NX_Q92569
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92569
PIK3R3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001107644.1 NP_003620.3
ENSEMBL proteins: ENSP00000361075 ENSP00000262741 ENSP00000391431 ENSP00000416647 ENSP00000439913 ENSP00000412546 ENSP00000346188 ENSP00000342484 Reactome Protein details: Q92569
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
TAS | -- | | GO:0005942 | phosphatidylinositol 3-kinase complex |
IEA | -- |
PIK3R3 for ontologies About GeneDecksing
PIK3R3 Antibody Products:
Assay Products for PIK3R3: |
Protein
Domains /
Families
for PIK3R3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PIK3R3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q92569ProtoNet protein and cluster: Q92569 2 Blocks protein families: IPB000980 SH2 domain signature IPB001720 PI3 kinase P85 regulatory subunit signature
UniProtKB/Swiss-Prot: P55G_HUMAN, Q92569Similarity: Belongs to the PI3K p85 subunit familySimilarity: Contains 2 SH2 domains |
Function
for PIK3R3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: P55G_HUMAN, Q92569Function: Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates theirkinase activity. During insulin stimulation, it also binds to IRS-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3R3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3R3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): PIK3R3 (NM_003629) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PIK3R3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3R3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3R3 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- | | GO:0016301 | kinase activity |
-- | -- | | GO:0016303 | 1-phosphatidylinositol-3-kinase activity |
TAS | 9524259 | | GO:0035014 | phosphatidylinositol 3-kinase regulator activity |
-- | -- | | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity |
IEA | -- |
PIK3R3 for ontologies About GeneDecksing
6 GenomeRNAi human phenotypes for PIK3R3:
|
Pathways & Interactions
for PIK3R3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/134 super-pathways (see all 134) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development_CNTF receptor signaling | | | 2 | Development HGF signaling pathway | | | 3 | IL-9 Signaling Pathways | | | 4 | Signaling by FGFR | | | 5 | ErbB4 Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/50 EMD Millipore Pathways for PIK3R3 (see all 50)
5/9  R&D Systems Pathways for PIK3R3 (see all 9)
5/132 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PIK3R3 (see all 132)
1 
Cell Signaling Technology (CST) Pathway for PIK3R3
5/9 Tocris Bioscience Pathways for PIK3R3 (see all 9)
5/51  GeneGo (Thomson Reuters) Pathways for PIK3R3 (see all 51)
5/9  BioSystems Pathways for PIK3R3 (see all 9)
5/54 
Reactome Pathways for PIK3R3 (see all 54)
3  PharmGKB Pathways for PIK3R3
5/43 
Kegg Pathways (Kegg details for PIK3R3) (see all 43):
PIK3R3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIK3R3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/314 Interacting proteins for PIK3R3 (Q925692, 3 ENSP000002627414) via UniProtKB, MINT, STRING, and/or I2D (see all 314)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006644 | phospholipid metabolic process |
TAS | -- | | GO:0006661 | phosphatidylinositol biosynthetic process |
TAS | -- | | GO:0007596 | blood coagulation |
TAS | -- | | GO:0008286 | insulin receptor signaling pathway |
IEA | -- | | GO:0030168 | platelet activation |
TAS | -- |
PIK3R3 for ontologies About GeneDecksing
|
Drugs & Compounds
for PIK3R3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PIK3R3 for compounds About GeneDecksing
Compounds for PIK3R3 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| LY 294002 hydrochloride | Selective PI 3-kinase inhibitor | [154447-36-6] | | Quercetin | Non-selective PI 3-kinase inhibitor | [117-39-5] | | PI 103 hydrochloride | Inhibitor of PI 3-kinase, mTOR and DNA-PK | [371935-74-9] | | BAG 956 | Dual PI 3-kinase and PDK1 inhibitor | [853910-02-8] | | PI 828 | PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130) | [942289-87-4] |
1 DrugBank Compound for PIK3R3 About this table
3 Novoseek chemical compound relationships for PIK3R3 gene About this table
Search CenterWatch for drugs/clinical trials and news about PIK3R3 / P55G
|
Transcripts
for PIK3R3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PIK3R3 gene (2 alternative transcripts): NM_001114172.1 NM_003629.3 Unigene Cluster for PIK3R3: Phosphoinositide-3-kinase, regulatory subunit 3 (gamma) Hs.655387 [show with all ESTs]Unigene Representative Sequence: NM_00362910 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372006(uc010olv.2 uc009vyc.3 uc010olw.2) ENST00000262741(uc001cpb.4 uc009vyb.3)
ENST00000488808 ENST00000423209 ENST00000493202 ENST00000425892 ENST00000540385
ENST00000420542(uc001cpc.4) ENST00000354242 ENST00000340332
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3R3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3R3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): PIK3R3 (NM_003629) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PIK3R3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3R3 |
Additional cDNA sequence: AF028785.1 AK123886.1 AK128500.1 AK302049.1 AK304713.1 AK313726.1 BC005381.1 BC021622.1 BC094768.1 BX537388.1 CR749649.1 D88532.1 U90907.1 Y13809.1 14 DOTS entries: DT.121350532 DT.455730 DT.99952226 DT.101977808 DT.91793082 DT.100795757 DT.40295165 DT.97845680 DT.100675455 DT.100721516 DT.121350502 DT.121350508 DT.92020310 DT.95163427 24/228 AceView cDNA sequences (see all 228): BF939650 BU509385 BX955117 AW341609 AI539154 AA365767 BM930832 BE673378 AW274231 AI289493 BF437723 AW473512 BG286826 AI273454 BX106694 BC021622 BC005381 BM475009 AW151374 BX955020 BG288110 Y13809 AI187850 BG289247
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PIK3R3 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 13b | ^ | 14a | · | 14b | · | 14c |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for PIK3R3
|
Expression
for PIK3R3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PIK3R3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See PIK3R3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PIK3R3
SOURCE GeneReport for Unigene cluster: Hs.655387
UniProtKB/Swiss-Prot: P55G_HUMAN, Q92569Tissue specificity: Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung andskeletal muscle
SABiosciences Expression via Pathway-Focused PCR Array including PIK3R3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PIK3R3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PIK3R3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIK3R3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIK3R3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3R3 |
Orthologs
for PIK3R3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PIK3R3 gene from 6/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PIK3R36 |
Uncharacterized protein |
53(a) |
1 ↔ 1 |
8(22149443-22201231) |
lizard
(Anolis carolinensis) |
Reptilia |
PIK3R36 |
-- |
92(a) |
1 ↔ 1 |
4(111456407-111467075) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.71102 |
Transcribed sequence with moderate similarity to protein more |
82.43(n) |
|
137713018 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc555642 |
similar to phosphoinositide-3-kinase, regulatory subunit, more |
81.28(n) |
|
394118 BC045386.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Pi3K21B6 |
Pi3K21B |
28(a) |
possible ortholog |
2L(297880-305233) |
worm
(Caenorhabditis elegans) |
Secernentea |
aap-16 |
phosphoinositide kinase AdAPter subunit family mem... |
21(a) |
1 → many |
I(5107844-5110167) |
ENSEMBL Gene Tree for PIK3R3 (if available)
TreeFam Gene Tree for PIK3R3 (if available) |
Paralogs
for PIK3R3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PIK3R3 gene
- PIK3R22 PIK3R12
5 SIMAP similar genes for PIK3R3 using alignment to 6 protein entries: P55G_HUMAN (see all proteins):DKFZp686F1293 DKFZp686P05226 PIK3R1 PIK3R2 PTPN11
PIK3R3 for paralogs About GeneDecksing
|
Genomic Variants
for PIK3R3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PIK3R3 (46505812 - 46642160 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PIK3R3
1 CNV: 4222 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PIK3R3 |
|
Disorders
/ Diseases
for PIK3R3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PIK3R3 for disorders About GeneDecksing
OMIM gene information: 606076
OMIM disorders: --
20/31  diseases for PIK3R3 (see all 31): About MalaCardsmyeloid leukemia chronic myeloid leukemia acute myeloid leukemia epithelial ovarian cancer
renal cell carcinoma cblc chagas disease hepatitis c
ovarian cancer trypanosomiasis toxoplasmosis measles
aldosteronism endometrial cancer leukemia colon cancer
influenza pancreatic cancer colorectal cancer lung cancer
Human Genome Epidemiology (HuGE) Navigator: PIK3R3 (3 documents)
Export disorders for PIK3R3 gene to outside databases
|
Publications
for PIK3R3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PIK3R3 gene, integrated from 9 sources (see all 48):
(articles sorted by number of sources associating them with PIK3R3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor. (PubMed id 9524259)1, 2, 3 Dey B.R.... Nissley S.P. (1998)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin. (PubMed id 12470648)1, 2 Hafizi S.... Dahlbaeck B. (2002)
- Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma. (PubMed id 17360667)1, 9 Soroceanu L....Phillips H.S. (2007)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Pooled analysis of phosphatidylinositol 3-kinase path way variants and risk of prostate cancer. (PubMed id 20197460)1 Koutros S....Berndt S.I. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (2009)
- Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. (PubMed id 18624398)1 Wang J....He F. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
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External Searches for PIK3R3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing PIK3R3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing PIK3R3 gene
(According to HUGE)
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Specialized Databases showing PIK3R3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for PIK3R3 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for PIK3R3 gene:
Search GeneIP for patents involving PIK3R3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PIK3R3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for PIK3R3 | | OriGene shRNA RFP for PIK3R3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PIK3R3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PIK3R3 | | | OriGene Protein Over-expression Lysate for PIK3R3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PIK3R3 | | OriGene 3'-UTR Clone for PIK3R3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3R3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3R3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PIK3R3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PIK3R3 | | OriGene Custom Protein Services for PIK3R3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PIK3R3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PIK3R3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIK3R3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIK3R3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIK3R3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIK3R3 |
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| | Antibodies & Assays for PIK3R3 |
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 | | | PIK3R3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3R3 |
|  |  |  | | | | ThermoFisher Antibodies for PIK3R3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3R3 |
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