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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PIK3R3 Gene

protein-coding   GIFtS: 64
GCID: GC01M046505

Phosphoinositide-3-Kinase, Regulatory Subunit 3 (Gamma)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phosphoinositide-3-Kinase, Regulatory Subunit 3 (Gamma)1 2     100% Homology To SWISS-PROT Q925692
Phosphatidylinositol 3-Kinase 55 KDa Regulatory Subunit Gamma2 3     p552
PtdIns-3-Kinase Regulatory Subunit Gamma2 3     p55-GAMMA2
PtdIns-3-Kinase Regulatory Subunit P55-Gamma2 3     Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma2
p55PIK2 3     Phosphatidylinositol 3-Kinase, Regulatory Subunit, Polypeptide 3 (P55,
Gamma)2
PI3-Kinase Regulatory Subunit Gamma2 3     Phosphoinositide-3-Kinase, Regulatory Subunit 3 (P55, Gamma)2
PI3-Kinase Subunit P55-Gamma2 3     Phosphoinositide-3-Kinase, Regulatory Subunit, Polypeptide 3 (P55, Gamma)2
PI3K Regulatory Subunit Gamma2 3     

External Ids:    HGNC: 89811   Entrez Gene: 85032   Ensembl: ENSG000001174617   OMIM: 6060765   UniProtKB: Q925693   

Export aliases for PIK3R3 gene to outside databases

Previous GC identifers: GC01M046199 GC01M045462 GC01M045892 GC01M045875 GC01M046217 GC01M044621


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PIK3R3 Gene: 
PIK3R3 (phosphoinositide-3-kinase, regulatory subunit 3 (gamma)) is a protein-coding gene. Diseases associated with PIK3R3 include cblc, and trypanosomiasis, and among its related super-pathways are IL-9 Signaling Pathways and Signal transduction AKT signaling. GO annotations related to this gene include 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-3-kinase regulator activity. An important paralog of this gene is PIK3R2.

UniProtKB/Swiss-Prot: P55G_HUMAN, Q92569
Function: Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their
kinase activity. During insulin stimulation, it also binds to IRS-1

summary for PIK3R3 Gene:
PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the
3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of
cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell
migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric
consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and
delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst
p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have
recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes
(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI
3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to
play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3R3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PIK3R3 gene promoter:
         Pax-5   Cart-1   c-Myb   Nkx2-5   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIK3R3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PIK3R3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIK3R3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p34.1

PIK3R3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIK3R3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M046505:  view genomic region     (about GC identifiers)

Start:
46,505,812 bp from pter      End:
46,642,160 bp from pter
Size:
136,349 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: P55G_HUMAN, Q92569 (See protein sequence)
Recommended Name: Phosphatidylinositol 3-kinase regulatory subunit gamma  
Size: 461 amino acids; 54448 Da
Subunit: Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD).
Interacts with AXL
Secondary accessions: B2R9C1 D3DQ12 O60482 Q5T4P1 Q5T4P2
Alternative splicing: 3 isoforms:  Q92569-1   Q92569-2   Q92569-3   

Explore the universe of human proteins at neXtProt for PIK3R3: NX_Q92569

Explore proteomics data for PIK3R3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92569

  • PIK3R3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PIK3R3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001107644.1  NP_003620.3  

    ENSEMBL proteins: 
     ENSP00000262741   ENSP00000361075   ENSP00000391431   ENSP00000416647   ENSP00000439913  
     ENSP00000412546   ENSP00000346188   ENSP00000342484  
    Reactome Protein details: Q92569
    Human Recombinant Protein Products for PIK3R3: 
    EMD Millipore Purified and/or Recombinant PIK3R3 Protein
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    Novus Biologicals PIK3R3 Proteins
    Novus Biologicals PIK3R3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PIK3R3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005942phosphatidylinositol 3-kinase complex IEA--

    PIK3R3 for ontologies           About GeneDecksing



    PIK3R3 Antibody Products: 
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    Abcam antibodies for PIK3R3
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    ThermoFisher Antibodies for PIK3R3
    LSBio Antibodies in human, mouse, rat for PIK3R3 

    Assay Products for PIK3R3: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SH2D: SH2 domain containing

    2 InterPro protein domains:
     IPR001720 PI3kinase_P85
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q92569

    ProtoNet protein and cluster: Q92569

    2 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001720 PI3 kinase P85 regulatory subunit signature


    UniProtKB/Swiss-Prot: P55G_HUMAN, Q92569
    Similarity: Belongs to the PI3K p85 subunit family
    Similarity: Contains 2 SH2 domains


    PIK3R3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P55G_HUMAN, Q92569
    Function: Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their
    kinase activity. During insulin stimulation, it also binds to IRS-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16273093
    GO:00163031-phosphatidylinositol-3-kinase activity TAS9524259
    GO:0035014phosphatidylinositol 3-kinase regulator activity IEA--
    GO:00469351-phosphatidylinositol-3-kinase regulator activity ----
         
    PIK3R3 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for PIK3R3:
     Decreased cilium length after   Decreased focal adhesion (FA)   Increased Salmonella enterica   Increased Salmonella enterica  
     Increased Salmonella enterica   Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PIK3R3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PIK3R3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PIK3R3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PIK3R3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIK3R3
    8/113 QIAGEN miScript miRNA Assays for microRNAs that regulate PIK3R3 (see all 113):
    hsa-miR-520e hsa-miR-607 hsa-miR-1321 hsa-miR-3074-3p hsa-miR-578 hsa-miR-4267 hsa-miR-298 hsa-miR-4274
    SwitchGear 3'UTR luciferase reporter plasmidPIK3R3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PIK3R3
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of PIK3R3

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): PIK3R3 (NM_003629)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIK3R3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3R3
    Sirion Biotech Customized lentivirus for stable overexpression of PIK3R3 
                         Customized lentivirus expression plasmids for stable overexpression of PIK3R3 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3R3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PIK3R3 About   (see all 134)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-4 Signaling Pathways0.84
    IL-7 Signaling Pathways0.90
    Immune response IL-9 signaling pathway0.42
    IL-21 Signaling Pathways0.90
    Development Thrombopoietin-regulated cell processes0.38
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    IL-9 Pathway0.36
    2Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    3Development FGF-family signaling
    Development FGF-family signaling0.63
    FGF Pathway0.38
    Development FGFR signaling pathway0.50
    4Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Development CNTF receptor signaling0.43
    Regulation of lipid metabolism Insulin signaling:generic cascades0.59
    Cell adhesion PLAU signaling0.35
    Transcription Receptor-mediated HIF regulation0.51
    mTOR signaling pathway0.34
    Translation Regulation activity of EIF20.47
    Insulin signaling pathway0.31
    5Development HGF signaling pathway
    Development HGF signaling pathway0.78
    Development EGFR signaling via PIP30.40
    Development Neurotrophin family signaling0.45
    Apoptosis and survival NGF signaling pathway0.36
    Development EGFR signaling via small GTPases0.44
    Neurotrophin signaling pathway0.36
    Development PDGF signaling via MAPK cascades0.41
    Renal cell carcinoma0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/50 EMD Millipore Pathways for PIK3R3 (see all 50)
        Immune response CD16 signaling in NK cells
    Cell adhesion PLAU signaling
    Cytoskeleton remodeling FAK signaling
    Signal transduction IP3 signaling
    Development Ligand-independent activation of ESR1 and ESR2

    5/10 R&D Systems Pathways for PIK3R3 (see all 10)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    IL-7 Signaling Pathways

    5/132 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PIK3R3 (see all 132)
        Fc-GammaR Pathway
    Toll-Like Receptors Pathway
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    JNK Pathway

    1 Cell Signaling Technology (CST) Pathway for PIK3R3
        PI3K / Akt Signaling

    5/9 Tocris Bioscience Pathways for PIK3R3 (see all 9)
        Akt Pathway
    Insulin Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    Toll-like Receptor Pathway

    5/51 GeneGo (Thomson Reuters) Pathways for PIK3R3 (see all 51)
        Development FGF-family signaling
    Development CNTF receptor signaling
    Signal transduction AKT signaling
    Development Endothelin-1/EDNRA signaling
    Immune response IL-9 signaling pathway

    5/9 BioSystems Pathways for PIK3R3 (see all 9)
        MicroRNAs in cardiomyocyte hypertrophy
    EGFR1 Signaling Pathway
    Insulin Signaling
    AMPK signaling
    Alpha6-Beta4 Integrin Signaling Pathway

    5/54        Reactome Pathways for PIK3R3 (see all 54)
        Costimulation by the CD28 family
    G alpha (12/13) signalling events
    Signaling by EGFR in Cancer
    Downstream signal transduction
    Signal Transduction

    3 PharmGKB Pathways for PIK3R3
        Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Sorafenib Pharmacodynamics

    5/54         Kegg Pathways  (Kegg details for PIK3R3) (see all 54):
        ErbB signaling pathway
    Chemokine signaling pathway
    HIF-1 signaling pathway
    Phosphatidylinositol signaling system
    mTOR signaling pathway


    PIK3R3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIK3R3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/318 Interacting proteins for PIK3R3 (Q925692, 3 ENSP000002627414) via UniProtKB, MINT, STRING, and/or I2D (see all 318)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046262, 3, ENSP000002695714MINT-74664 MINT-74642 MINT-74650 MINT-74662 MINT-74660 MINT-74649 MINT-74663 MINT-74641 MINT-74661 I2D: score=2 STRING: ENSP00000269571
    ERBB3P218602, 3, ENSP000002671014MINT-74643 MINT-74669 MINT-74652 MINT-74647 MINT-74651 MINT-74656 MINT-74653 MINT-74672 MINT-74644 MINT-74668 MINT-74646 MINT-74645 MINT-74667 MINT-74654 MINT-74666 MINT-74665 MINT-74657 MINT-74670 MINT-74655 MINT-74671 I2D: score=2 STRING: ENSP00000267101
    ABI1Q8IZP02, 3, ENSP000003653124MINT-7908283 MINT-7908490 I2D: score=1 STRING: ENSP00000365312
    C7orf55-LUC7L2Q9Y3832, 3MINT-8266271 I2D: score=2 
    LUC7L2Q9Y3832, 3MINT-8266271 I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0008286insulin receptor signaling pathway TAS9524259
    GO:0036092phosphatidylinositol-3-phosphate biosynthetic process TAS9524259
    GO:0044281small molecule metabolic process TAS--

    PIK3R3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PIK3R3 for compounds           About GeneDecksing

    EMD Millipore small molecules for PIK3R3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PIK3R3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CZC 24832Selective inhibitor of PI 3-Kinase gamma[1159824-67-5]
    QuercetinNon-selective PI 3-kinase inhibitor[117-39-5]
    PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK [371935-74-9]
    AS 605240Potent and selective PI 3-kinase gamma (PI3Kgamma) inhibitor[648450-29-7]
    740 Y-PCell-permeable PI 3-kinase activator[1236188-16-1]

    1 DrugBank Compound for PIK3R3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    IsoproterenolEpinephrine Isopropyl Homolog (see all 14)7683-59-2targetagonist15985706 15527548 15381832 15618457 15110780

    3 Novoseek inferred chemical compound relationships for PIK3R3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 73.6 18 16513646 (3), 20093365 (3), 15266020 (2), 11042169 (2) (see all 11)
    phosphoinositide 54.2 6 17360667 (2), 16321969 (1)
    tyrosine 11.9 2 15266020 (1), 9391111 (1)

    Search CenterWatch for drugs/clinical trials and news about PIK3R3 / P55G

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PIK3R3 gene (2 alternative transcripts): 
    NM_001114172.1  NM_003629.3  

    Unigene Cluster for PIK3R3:

    Phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
    Hs.655387  [show with all ESTs]
    Unigene Representative Sequence: NM_003629
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262741(uc001cpb.4 uc009vyb.3) ENST00000372006(uc010olv.2 uc009vyc.3 uc010olw.2)
    ENST00000488808 ENST00000423209 ENST00000493202 ENST00000425892 ENST00000540385
    ENST00000420542(uc001cpc.4) ENST00000354242 ENST00000340332
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidPIK3R3 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIK3R3
    Clone
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    OriGene clones in human, mouse for PIK3R3 (see all 13)
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    GenScript: all cDNA clones in your preferred vector (see all 2): PIK3R3 (NM_003629)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIK3R3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3R3
    Sirion Biotech Customized lentivirus for stable overexpression of PIK3R3 
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIK3R3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIK3R3

    Additional mRNA sequence: 

    AF028785.1 AK123886.1 AK128500.1 AK302049.1 AK304713.1 AK313726.1 BC005381.1 BC021622.1 
    BC094768.1 BX537388.1 CR749649.1 D88532.1 U90907.1 Y13809.1 

    14 DOTS entries:

    DT.121350532  DT.455730  DT.99952226  DT.101977808  DT.91793082  DT.100795757  DT.40295165  DT.97845680 
    DT.100675455  DT.100721516  DT.121350502  DT.121350508  DT.92020310  DT.95163427 

    24/228 AceView cDNA sequences (see all 228):

    BC021622 BG289247 AW341542 AW188066 AA843698 AW151842 H64719 BG286826 
    AW008883 BX106694 BC005381 AW274231 CB158818 BF437723 AA346603 AW473512 
    BM684922 AA256997 BM475009 AW592318 CB163121 U90907 BU682687 BM455418 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PIK3R3 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a ·
    SP1:                                -     -     -                 -                                                     -           -     -     -               
    SP2:                                                              -                                                     -           -     -     -               
    SP3:                                                              -                                                     -     -     -     -     -               
    SP4:                          -     -     -     -     -     -     -                                                                                             
    SP5:                          -     -     -     -                                                                                                               

    ExUns: 13b ^ 14a · 14b · 14c
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for PIK3R3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PIK3R3 expression in normal human tissues (normalized intensities)      PIK3R3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PIK3R3 Expression
    About this image


    PIK3R3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
             brain/midbrain   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             seminal vesicle ; glandular cells   
             sperm   
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             nasopharynx ; respiratory epithelial cells   
             sensory organ/nose/nasal cavity   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See PIK3R3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PIK3R3

    SOURCE GeneReport for Unigene cluster: Hs.655387

    UniProtKB/Swiss-Prot: P55G_HUMAN, Q92569
    Tissue specificity: Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and
    skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including PIK3R3: 
              VEGF Signaling in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PIK3R3 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pik3r31 , 5 phosphatidylinositol 3 kinase, regulatory subunit, more1, 5 91.83(n)1
    95.88(a)1
      4 (53.10 cM)5
    187101  NM_181585.51  NP_853616.11 
     1162216185 
    chicken
    (Gallus gallus)
    Aves PIK3R36
    phosphoinositide-3-kinase, regulatory subunit 3 (g...
    53(a)
    1 ↔ 1
    8(20334389-20385736)
    lizard
    (Anolis carolinensis)
    Reptilia PIK3R36
    Uncharacterized protein
    89(a)
    1 ↔ 1
    4(111456407-111502112)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.71102 Transcribed sequence with moderate similarity to protein more 82.43(n)    137713018 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc555642 similar to phosphoinositide-3-kinase, regulatory subunit, more 81.28(n)   394118  BC045386.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pi3K21B6
    Pi3K21B
    28(a)
    1 → many
    2L(297880-305233)
    worm
    (Caenorhabditis elegans)
    Secernentea aap-16
    Protein AAP-1
    20(a)
    1 → many
    I(5107841-5110164)


    ENSEMBL Gene Tree for PIK3R3 (if available)
    TreeFam Gene Tree for PIK3R3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PIK3R3 gene
    PIK3R22  PIK3R12  ENSG000002681732  
    5 SIMAP similar genes for PIK3R3 using alignment to 6 protein entries:     P55G_HUMAN (see all proteins):
    DKFZp686F1293    DKFZp686P05226    PIK3R1    PIK3R2    PTPN11

    PIK3R3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1745 SNPs in PIK3R3 are shown (see all 1745)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs567680761,2
    C--44653689(+) TATAT-/ATTAGGC 2 -- int11Minor allele frequency- AT:0.00NA 2
    rs106479441,2
    C--44708008(+) aaaaa-/T/TAT 
            
    aTATA
    4 -- int1 cds1 trp30--------
    rs1906104811,2
    --46505313(+) AATATC/TCTATG 2 -- int10--------
    rs1818682501,2
    --46505342(+) TGTTGA/GCTCAT 2 -- int10--------
    rs1864295731,2
    --46505343(+) GTTGGC/GTCATT 2 -- int10--------
    rs1908826541,2
    --46505351(+) ATTACA/GTTCCC 2 -- int10--------
    rs1456671181,2
    C--46505403(+) CAAGGA/GCCTGG 2 -- int10--------
    rs1167035701,2
    C,F--46505514(+) ACAGCT/GTATTA 2 -- int11Minor allele frequency- G:0.01NA 120
    rs114441021,2
    C--46505589(+) ACTTCC/-TGTGT 2 -- int11Minor allele frequency- -:0.00NA 2
    rs793665761,2
    C--46505589(+) AGACTC/TCTGTG 2 -- int10--------

    HapMap Linkage Disequilibrium report for PIK3R3 (46505812 - 46642160 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PIK3R3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508012CNV Loss20534489
    nsv829737CNV Gain17160897
    nsv871928CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606076    OMIM disorders: --

    20/29 diseases for PIK3R3 (see all 29):    About MalaCards
    cblc    trypanosomiasis    chagas disease    toxoplasmosis
    measles    chronic myeloid leukemia    myeloid leukemia    huntington's disease
    acute myeloid leukemia    influenza    glioblastoma    ovarian cancer
    renal cell carcinoma    hepatitis c    diabetes mellitus    pancreatic cancer
    colon cancer    leukemia    colorectal cancer    pancreatitis


    PIK3R3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PIK3R3
    Human Genome Epidemiology (HuGE) Navigator: PIK3R3 (3 documents)

    Export disorders for PIK3R3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PIK3R3 gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with PIK3R3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor. (PubMed id 9524259)1, 2, 3 Dey B.R.... Nissley S.P. (1998)
    2. Pooled analysis of phosphatidylinositol 3-kinase path way variants and risk of prostate cancer. (PubMed id 20197460)1, 4 Koutros S....Berndt S.I. (2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin. (PubMed id 12470648)1, 2 Hafizi S.... Dahlbaeck B. (2002)
    6. Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma. (PubMed id 17360667)1, 9 Soroceanu L....Phillips H.S. (2007)
    7. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (2013)
    8. MicroRNA-7-regulated TLR9 signaling-enhanced growth an d metastatic potential of human lung cancer cells by altering the phosphoinositi de-3-kinase, regulatory subunit 3/Akt pathway. (PubMed id 23135998)1 Xu L....Ren T. (2013)
    9. Blocking p55PIK signaling inhibits proliferation and i nduces differentiation of leukemia cells. (PubMed id 22722333)1 Wang G....Hu J. (2012)
    10. Genetic and bioinformatic analyses of the expression a nd function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library. (PubMed id 22876838)1 Zhou J....Yen P.M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8503 HGNC: 8981 AceView: PIK3R3 Ensembl:ENSG00000117461 euGenes: HUgn8503
    ECgene: PIK3R3 Kegg: 8503 H-InvDB: PIK3R3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PIK3R3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PIK3R3 gene:
    Search GeneIP for patents involving PIK3R3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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