Aliases for PIK3R3 Gene
External Ids for PIK3R3 Gene
Previous GeneCards Identifiers for PIK3R3 Gene
GeneCards Summary for PIK3R3 Gene
PIK3R3 (Phosphoinositide-3-Kinase, Regulatory Subunit 3 (Gamma)) is a Protein Coding gene. Diseases associated with PIK3R3 include intravenous leiomyomatosis. Among its related pathways are PI3K-Akt signaling pathway and PI3K/AKT Signaling in Cancer. GO annotations related to this gene include 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-3-kinase regulator activity. An important paralog of this gene is PIK3R1.
UniProtKB/Swiss-Prot for PIK3R3 Gene
Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1
PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.