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Aliases for PIK3R3 Gene

Aliases for PIK3R3 Gene

  • Phosphoinositide-3-Kinase Regulatory Subunit 3 5 2 3
  • Phosphatidylinositol 3-Kinase 55 KDa Regulatory Subunit Gamma 3 4
  • Phosphoinositide-3-Kinase, Regulatory Subunit 3 (Gamma) 2 3
  • Phosphoinositide-3-Kinase Regulatory Subunit Gamma 2 3
  • PtdIns-3-Kinase Regulatory Subunit P55-Gamma 3 4
  • PI3-Kinase Regulatory Subunit Gamma 3 4
  • PI3K Regulatory Subunit Gamma 3 4
  • PI3-Kinase Subunit P55-Gamma 3 4
  • P55PIK 3 4
  • Phosphatidylinositol 3-Kinase, Regulatory Subunit, Polypeptide 3 (P55, Gamma) 3
  • Phosphoinositide-3-Kinase, Regulatory Subunit, Polypeptide 3 (P55, Gamma) 3
  • PtdIns-3-Kinase Regulatory Subunit Gamma 4
  • P55-GAMMA 3
  • P55 3

External Ids for PIK3R3 Gene

Previous GeneCards Identifiers for PIK3R3 Gene

  • GC01M046199
  • GC01M045462
  • GC01M045892
  • GC01M045875
  • GC01M046217
  • GC01M046505
  • GC01M044621

Summaries for PIK3R3 Gene

GeneCards Summary for PIK3R3 Gene

PIK3R3 (Phosphoinositide-3-Kinase Regulatory Subunit 3) is a Protein Coding gene. Diseases associated with PIK3R3 include Intravenous Leiomyomatosis. Among its related pathways are Glioma and CTLA4 Signaling. GO annotations related to this gene include 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-3-kinase regulator activity. An important paralog of this gene is ENSG00000278139.

UniProtKB/Swiss-Prot for PIK3R3 Gene

  • Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

Tocris Summary for PIK3R3 Gene

  • PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.

Gene Wiki entry for PIK3R3 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIK3R3 Gene

Genomics for PIK3R3 Gene

Regulatory Elements for PIK3R3 Gene

Enhancers for PIK3R3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PIK3R3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PIK3R3 Gene

46,040,140 bp from pter
46,176,495 bp from pter
136,356 bases
Minus strand

Genomic View for PIK3R3 Gene

Genes around PIK3R3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIK3R3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIK3R3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIK3R3 Gene

Proteins for PIK3R3 Gene

  • Protein details for PIK3R3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphatidylinositol 3-kinase regulatory subunit gamma
    Protein Accession:
    Secondary Accessions:
    • B2R9C1
    • D3DQ12
    • O60482
    • Q5T4P1
    • Q5T4P2

    Protein attributes for PIK3R3 Gene

    461 amino acids
    Molecular mass:
    54448 Da
    Quaternary structure:
    • Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL.

    Alternative splice isoforms for PIK3R3 Gene


neXtProt entry for PIK3R3 Gene

Proteomics data for PIK3R3 Gene at MOPED

Post-translational modifications for PIK3R3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for PIK3R3 (PI 3-Kinase p55 gamma)
  • Cell Signaling Technology (CST) Antibodies for PIK3R3 (PIK3R3)

No data available for DME Specific Peptides for PIK3R3 Gene

Domains & Families for PIK3R3 Gene

Gene Families for PIK3R3 Gene

Protein Domains for PIK3R3 Gene

Suggested Antigen Peptide Sequences for PIK3R3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 SH2 domains.
  • Belongs to the PI3K p85 subunit family.
  • Contains 2 SH2 domains.
  • Belongs to the PI3K p85 subunit family.
genes like me logo Genes that share domains with PIK3R3: view

Function for PIK3R3 Gene

Molecular function for PIK3R3 Gene

UniProtKB/Swiss-Prot Function:
Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.
genes like me logo Genes that share phenotypes with PIK3R3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIK3R3 Gene

Localization for PIK3R3 Gene

Subcellular locations from

Jensen Localization Image for PIK3R3 Gene COMPARTMENTS Subcellular localization image for PIK3R3 gene
Compartment Confidence
cytosol 5
nucleus 3
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PIK3R3 Gene

Pathways & Interactions for PIK3R3 Gene

SuperPathways for PIK3R3 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 PI3K events in ERBB4 signaling
3 IL-7 Signaling Pathways
4 IL-2 Pathway
5 Translation Insulin regulation of translation
genes like me logo Genes that share pathways with PIK3R3: view

Pathways by source for PIK3R3 Gene

SIGNOR curated interactions for PIK3R3 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for PIK3R3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process TAS 9524259
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with PIK3R3: view

Drugs & Compounds for PIK3R3 Gene

(26) Drugs for PIK3R3 Gene - From: DrugBank, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isoproterenol Approved Pharma Full agonist, Agonist, Target, agonist 20
Quercetin Experimental Nutra Antitumor agent, Non-selective PI 3-kinase inhibitor 36
SF1126 Investigational Pharma inhibitor, Target Kinase Inhibitors 0
XL147 Investigational Pharma inhibitor PI3K inhibitor,selective and reversible, Kinase Inhibitors, Phosphatidylinositol-3- kinase (PI-3K) inhibitors 0
BAY80-6946 Pharma Inhibition, Biomarker, inhibitor PI3K Inhibitors, Kinase Inhibitors 0

(4) Additional Compounds for PIK3R3 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LY 294002 hydrochloride
LY 303511

(5) Tocris Compounds for PIK3R3 Gene

Compound Action Cas Number
740 Y-P Cell-permeable PI 3-kinase activator 1236188-16-1
LY 294002 hydrochloride Prototypical PI 3-kinase inhibitor; also inhibits other kinases 934389-88-5
LY 303511 Negative control of LY 294002 (Cat. No. 1130) 154447-38-8
Quercetin Non-selective PI 3-kinase inhibitor 117-39-5
Wortmannin Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 19545-26-7
genes like me logo Genes that share compounds with PIK3R3: view

Transcripts for PIK3R3 Gene

Unigene Clusters for PIK3R3 Gene

Phosphoinositide-3-kinase, regulatory subunit 3 (gamma):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIK3R3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a ·
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - -
SP8: - -

ExUns: 13b ^ 14a · 14b · 14c

Relevant External Links for PIK3R3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PIK3R3 Gene

mRNA expression in normal human tissues for PIK3R3 Gene

Protein differential expression in normal tissues from HIPED for PIK3R3 Gene

This gene is overexpressed in Testis (56.2) and Spleen (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PIK3R3 Gene

SOURCE GeneReport for Unigene cluster for PIK3R3 Gene Hs.655387

mRNA Expression by UniProt/SwissProt for PIK3R3 Gene

Tissue specificity: Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle.
genes like me logo Genes that share expression patterns with PIK3R3: view

Protein tissue co-expression partners for PIK3R3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PIK3R3 Gene

Orthologs for PIK3R3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PIK3R3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PIK3R3 35
  • 93.78 (n)
  • 97.18 (a)
PIK3R3 36
  • 98 (a)
(Canis familiaris)
Mammalia PIK3R3 35
  • 94.96 (n)
  • 98.56 (a)
PIK3R3 36
  • 99 (a)
(Mus musculus)
Mammalia Pik3r3 35
  • 91.83 (n)
  • 95.88 (a)
Pik3r3 16
Pik3r3 36
  • 96 (a)
(Pan troglodytes)
Mammalia PIK3R3 35
  • 99.78 (n)
  • 99.78 (a)
PIK3R3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Pik3r3 35
  • 90.89 (n)
  • 94.79 (a)
(Monodelphis domestica)
Mammalia PIK3R3 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia PIK3R3 36
  • 89 (a)
(Gallus gallus)
Aves PIK3R3 35
  • 83.61 (n)
  • 91.61 (a)
PIK3R3 36
  • 55 (a)
(Anolis carolinensis)
Reptilia PIK3R3 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pik3r3 35
  • 80.55 (n)
  • 88.94 (a)
Str.7110 35
(Danio rerio)
Actinopterygii pik3r3b 35
  • 75.05 (n)
  • 86.55 (a)
zgc55564 35
pik3r3b 36
  • 86 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pi3K21B 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea aap-1 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 2 (a)
Species with no ortholog for PIK3R3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIK3R3 Gene

Gene Tree for PIK3R3 (if available)
Gene Tree for PIK3R3 (if available)

Paralogs for PIK3R3 Gene

Paralogs for PIK3R3 Gene

(5) SIMAP similar genes for PIK3R3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PIK3R3: view

Variants for PIK3R3 Gene

Sequence variations from dbSNP and Humsavar for PIK3R3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs785467 - 46,055,887(-) AAGAA(A/T)CAAGC intron-variant, reference, missense
rs785462 -- 46,060,079(-) tctgt(C/T)gccca intron-variant
rs785463 -- 46,058,562(-) gctga(C/T)gcaag intron-variant
rs785464 -- 46,057,417(-) tcccc(A/G)ttttc intron-variant
rs785465 -- 46,056,905(-) tcaga(G/T)gtagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIK3R3 Gene

Variant ID Type Subtype PubMed ID
nsv871928 CNV Gain 21882294
nsv829737 CNV Gain 17160897
nsv508012 CNV Loss 20534489

Variation tolerance for PIK3R3 Gene

Residual Variation Intolerance Score: 34.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIK3R3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIK3R3 Gene

Disorders for PIK3R3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PIK3R3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
intravenous leiomyomatosis
  • leiomyomatosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PIK3R3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PIK3R3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIK3R3 Gene

Publications for PIK3R3 Gene

  1. Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor. (PMID: 9524259) Dey B.R. … Nissley S.P. (Gene 1998) 2 3 4 67
  2. Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma. (PMID: 17360667) Soroceanu L. … Phillips H.S. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 23
  3. Activation of PI3K-Akt pathway mediates antiapoptotic effects of beta-adrenergic agonist in airway eosinophils. (PMID: 15618457) Machida K. … Nakanishi Y. (Am. J. Physiol. Lung Cell Mol. Physiol. 2005) 25 26
  4. Gastric mucin secretion in response to beta-adrenergic G protein-coupled receptor activation is mediated by SRC kinase-dependent epidermal growth factor receptor transactivation. (PMID: 15985706) SA8omiany B.L. … SA8omiany A. (J. Physiol. Pharmacol. 2005) 25 26
  5. Salivary phospholipid secretion in response to beta-adrenergic stimulation is mediated by Src kinase-dependent epidermal growth factor receptor transactivation. (PMID: 15110780) Slomiany B.L. … Slomiany A. (Biochem. Biophys. Res. Commun. 2004) 25 26

Products for PIK3R3 Gene

Sources for PIK3R3 Gene