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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PIK3R2 Gene

protein-coding GIFtS: 66
GCID: GC19P018263

phosphoinositide-3-kinase, regulatory subunit 2 (beta)

Explore 39 diseases affiliated with
PIK3R2 via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phosphoinositide-3-Kinase, Regulatory Subunit 2 (Beta)¹ ²		MPPH²
P85B¹ ²		P85-BETA¹
P85¹		Phosphatidylinositol 3-Kinase Regulatory Subunit Beta²
Phosphatidylinositol 3-Kinase 85 KDa Regulatory Subunit Beta² ³		Phosphatidylinositol 3-Kinase, Regulatory Subunit, Polypeptide 2 (P85 Beta)²
PtdIns-3-Kinase Regulatory Subunit P85-Beta² ³		PI3-Kinase Regulatory Subunit Beta³
PI3-Kinase Subunit P85-Beta² ³		PtdIns-3-Kinase Regulatory Subunit Beta³
PI3K Regulatory Subunit Beta² ³

External Ids:	HGNC: 8980¹	Entrez Gene: 5296²	Ensembl: ENSG00000105647⁷	OMIM: 603157⁵	UniProtKB: O00459³

Export aliases for PIK3R2 gene to outside databases

Previous GC identifers: GC19P018760 GC19P018658 GC19P018108 GC19P018127 GC19P018089 GC19P017828

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PIK3R2:

Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds,

creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and

a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one

protein coding and the other non-protein coding, have been found for this gene. (provided by RefSeq, Dec 2012)

UniProtKB/Swiss-Prot: P85B_HUMAN, O00459

Function: Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter,

mediating the association of the p110 catalytic unit to the plasma membrane

summary for PIK3R2:

PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the

3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of

cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell

migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric

consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and

delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst

p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have

recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes

(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI

3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to

play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3R2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PIK3R2 gene promoter:
Spz1 Elk-1 SREBP-1c Egr-1 AP-4 CUTL1 SREBP-1b CREB SREBP-1a deltaCREB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PIK3R2 promoter sequence

Search SABiosciences Chromatin IP Primers for PIK3R2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIK3R2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2-q13.4 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19q13.2-q13.4

PIK3R2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIK3R2 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P018263: view genomic region (about GC identifiers)

Start:	18,263,928 bp from pter	End:	18,281,343 bp from pter
Size:	17,416 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: P85B_HUMAN, O00459 (See protein sequence)

Recommended Name: Phosphatidylinositol 3-kinase regulatory subunit beta

Size: 728 amino acids; 81545 Da

Subunit: Heterodimer of a regulatory subunit PIK3R2 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts

with AXL. Interacts with FLT1 (tyrosine-phosphorylated) and FLT4 (tyrosine-phosphorylated). Interacts with NYAP1,

NYAP2 and MYO16

4 PDB 3D structures from and Proteopedia for PIK3R2:

2KT1 (3D)

2XS6 (3D)

3MTT (3D)

3O5Z (3D)

Secondary accessions: Q5EAT5 Q9UPH9

Explore the universe of human proteins at neXtProt for PIK3R2: NX_O00459

Post-translational modifications:

Phosphorylated in response to signaling from activated receptor-type protein kinases. Dephosphorylated by PTPRJ¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O00459

PIK3R2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005018.1

ENSEMBL proteins:

ENSP00000222254 ENSP00000395636

Reactome Protein details: O00459
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant PIK3R2 Protein
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	Uscn Proteins for PIK3R2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0005942	phosphatidylinositol 3-kinase complex	IEA	--

PIK3R2 for ontologies About GeneDecksing

PIK3R2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Uscn Antibodies for PIK3R2
	ThermoFisher Antibodies for PIK3R2

Assay Products for PIK3R2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for PIK3R2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PIK3R2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PIK3R2 for domains About GeneDecksing

5 InterPro domains/families:

IPR008936 Rho_GTPase_activation_prot

IPR001720 PI3kinase_P85

IPR001452 SH3_domain

IPR000980 SH2

IPR000198 RhoGAP_dom

Graphical View of Domain Structure for InterPro Entry O00459

ProtoNet protein and cluster: O00459

3 Blocks protein families:

IPB000198 RhoGAP domain

IPB000980 SH2 domain signature

IPB001720 PI3 kinase P85 regulatory subunit signature

UniProtKB/Swiss-Prot: P85B_HUMAN, O00459

Similarity: Belongs to the PI3K p85 subunit family

Similarity: Contains 1 Rho-GAP domain

Similarity: Contains 2 SH2 domains

Similarity: Contains 1 SH3 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: P85B_HUMAN, O00459

Function: Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter,

mediating the association of the p110 catalytic unit to the plasma membrane

Genatlas biochemistry entry for PIK3R2:

phosphatidylinositol 3-kinase (p85 beta),regulatory subunit,class IA adaptor molecule associating 110-120kDa catalytic

subunits,interacting with tyrosine kinase (signal transduction),interacting with inositol polyphosphatase

4-phosphatase and inositol polyphosphatase 5-phosphatase,expressed in B and T cells

miRNA Products:		miRTarBase miRNAs that target PIK3R2: hsa-mir-126 (MIRT003894)

		OriGene 3'-UTR Clone: PIK3R2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIK3R2
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate PIK3R2 (see all 15):
		hsa-miR-30c hsa-miR-4271 hsa-miR-3607-3p hsa-miR-3678-5p hsa-miR-30d hsa-miR-4258 hsa-miR-3667-3p hsa-miR-135b

		SwitchGear 3'UTR luciferase reporter plasmid: PIK3R2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PIK3R2 (see all 7) OriGene shRNA RFP: PIK3R2 OriGene siRNA: PIK3R2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIK3R2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PIK3R2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: PIK3R2 (NM_005027)
		Browse Sino Biological Human cDNA Clones
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PIK3R2
		Search LifeMap BioReagents cell lines for PIK3R2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3R2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0016303	contributes to 1-phosphatidylinositol-3-kinase activity	ISS	--
GO:0030971	receptor tyrosine kinase binding	IPI	10627473
GO:0035014	phosphatidylinositol 3-kinase regulator activity	IEA	--

PIK3R2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for PIK3R2:

Decreased viability

Increased apoptosis

Animal Models:
Mouse knock-out Pik3r2^tm1Lca for PIK3R2
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pik3r2):

cardiovascular system

homeostasis/metabolism

muscle

tumorigenesis

PIK3R2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/161 super-pathways (see all 161) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development HGF signaling pathway

8/19 pathways (see all 19)
Development HGF signaling pathway	1.00	Apoptosis and survival_NGF signaling pathway	0.25
Development_HGF signaling pathway	0.78	Apoptosis and survival NGF signaling pathway	0.25
Development_Neurotrophin family signaling	0.45	Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR1	0.24
Development Neurotrophin family signaling	0.45	Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1	0.24

Development_CNTF receptor signaling

8/18 pathways (see all 18)
Development_CNTF receptor signaling	1.00	Translation Insulin regulation of translation	0.35
Development CNTF receptor signaling	1.00	Translation _Regulation of EIF4F activity	0.32
Transcription Receptor-mediated HIF regulation	0.43	Translation Regulation activity of EIF4F	0.32
Transcription_Receptor-mediated HIF regulation	0.43	Translation _Regulation of EIF2 activity	0.25

IL-9 Signaling Pathways

8/13 pathways (see all 13)
IL-9 Signaling Pathways	1.00	Immune response_IL-9 signaling pathway	0.42
IL-21 Signaling Pathways	0.90	Immune response IL-9 signaling pathway	0.42
IL-7 Signaling Pathways	0.90	Development_Thrombopoietin-regulated cell processes	0.36
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways	0.90	Development Thrombopoietin-regulated cell processes	0.36

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

ErbB4 Pathway

8/11 pathways (see all 11)
ErbB4 Pathway	1.00	LPS Stimulated MAPK Signaling	0.36
ErbB Family Pathway	0.59	TREM1 Pathway	0.32
Prolactin Signaling	0.54	HMGB1 Pathway	0.32
ErbB2-ErbB3 Heterodimers	0.47	Growth Hormone Signaling	0.32

Pathway sources
See GeneCards unified pathways
Show all pathways

5/62 EMD Millipore Pathways for PIK3R2 (see all 62)

	Immune response CD16 signaling in NK cells
	Cell adhesion PLAU signaling
	Cytoskeleton remodeling FAK signaling
	Signal transduction IP3 signaling
	Cytoskeleton remodeling Role of PDGFs in cell migration

5/9 R&D Systems Pathways for PIK3R2 (see all 9)

	IL-21 Signaling Pathways
	IL-2 Signaling Pathways
	IL-4 Signaling Pathways
	Adipocytokines & Insulin Signaling
	IL-7 Signaling Pathways

5/128 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PIK3R2 (see all 128)

	UVB-Induced MAPK Signaling
	Fc-GammaR Pathway
	Toll-Like Receptors Pathway
	Molecular Mechanisms of Cancer
	eIF2 Pathway

1 Cell Signaling Technology (CST) Pathway for PIK3R2

PI3K / Akt Signaling

5/9 Tocris Bioscience Pathways for PIK3R2 (see all 9)

	Akt Pathway
	Insulin Pathway
	Apoptosis Pathway
	NF-kappaB Pathway
	Toll-like Receptor Pathway

5/63 GeneGo (Thomson Reuters) Pathways for PIK3R2 (see all 63)

	Cytoskeleton remodeling Role of PDGFs in cell migration
	Development FGF-family signaling
	Development CNTF receptor signaling
	Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
	Development EGFR signaling pathway

5/30 BioSystems Pathways for PIK3R2 (see all 30)

	EGFR1 Signaling Pathway
	Focal Adhesion
	Integrin-mediated cell adhesion
	AMPK signaling
	MicroRNAs in cardiomyocyte hypertrophy

5/72 Reactome Pathways for PIK3R2 (see all 72)

	Nephrin interactions
	IRS-mediated signalling
	Signaling by PDGF
	Downstream Signaling Events Of B Cell Receptor (BCR)
	Signalling by NGF

3 PharmGKB Pathways for PIK3R2

	Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
	EGFR Inhibitor Pathway, Pharmacodynamics
	Sorafenib Pharmacodynamics

5/43 Kegg Pathways (Kegg details for PIK3R2) (see all 43):

	ErbB signaling pathway
	Chemokine signaling pathway
	Phosphatidylinositol signaling system
	mTOR signaling pathway
	Apoptosis

PIK3R2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PIK3R2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/367 Interacting proteins for PIK3R2 (O00459^{1, 2, 3} ENSP00000222254⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 367)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ERBB3	P21860²^,³, ENSP00000267101⁴	MINT-74627 MINT-74618 MINT-61512 MINT-74629 MINT-74637 MINT-61520 MINT-74625 MINT-74638 MINT-61513 MINT-74624 MINT-74636 MINT-74633 MINT-61519 MINT-74628 MINT-74626 MINT-74639 MINT-61516 MINT-74635 MINT-74634 MINT-61517 I2D: score=5 STRING: ENSP00000267101
ERBB2	P04626²^,³, ENSP00000269571⁴	MINT-74622 MINT-74623 MINT-74620 MINT-74631 MINT-74621 MINT-61505 MINT-74632 I2D: score=5 STRING: ENSP00000269571
GRB2	P62993¹^,³, ENSP00000339007⁴	EBI-346930,EBI-401755 I2D: score=5 STRING: ENSP00000339007
KIT	P10721²^,³, ENSP00000288135⁴	MINT-8037279 I2D: score=5 STRING: ENSP00000288135
YWHAB	P31946²^,³, ENSP00000300161⁴	MINT-50949 I2D: score=3 STRING: ENSP00000300161

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006644	phospholipid metabolic process	TAS	--
GO:0006661	phosphatidylinositol biosynthetic process	TAS	--
GO:0007165	signal transduction	--	--
GO:0007264	small GTPase mediated signal transduction	TAS	--
GO:0007596	blood coagulation	TAS	--

PIK3R2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PIK3R2 for compounds About GeneDecksing

EMD Millipore small molecules for PIK3R2:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for PIK3R2 available from Tocris Bioscience About this table

Compound	Action	CAS #
LY 294002 hydrochloride	Selective PI 3-kinase inhibitor	[154447-36-6]
Quercetin	Non-selective PI 3-kinase inhibitor	[117-39-5]
PI 103 hydrochloride	Inhibitor of PI 3-kinase, mTOR and DNA-PK	[371935-74-9]
BAG 956	Dual PI 3-kinase and PDK1 inhibitor	[853910-02-8]
PI 828	PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130)	[942289-87-4]

1 DrugBank Compound for PIK3R2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Isoproterenol	Epinephrine Isopropyl Homolog (see all 14)	7683-59-2	target	agonist	15985706 15527548 15381832 15618457 15110780

3 Novoseek chemical compound relationships for PIK3R2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphatidylinositol	73.2	15	8388374 (3), 7961856 (3), 9054447 (3), 9819398 (1) (see all 7)
phosphoinositide	55.5	4	14504291 (3)
threonine	25.9	1	8388374 (1)

Search CenterWatch for drugs/clinical trials and news about PIK3R2 / P85B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PIK3R2 gene:

NM_005027.3

Unigene Cluster for PIK3R2:

Phosphoinositide-3-kinase, regulatory subunit 2 (beta)

Hs.371344 [show with all ESTs]

Unigene Representative Sequence: NR_073517

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000222254(uc002nia.1 uc002nib.1 uc010ebi.1) ENST00000473973

ENST00000426902 ENST00000474310 ENST00000464016 ENST00000459743 ENST00000470732

miRNA Products:		OriGene 3'-UTR Clone: PIK3R2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIK3R2
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate PIK3R2 (see all 15):
		hsa-miR-30c hsa-miR-4271 hsa-miR-3607-3p hsa-miR-3678-5p hsa-miR-30d hsa-miR-4258 hsa-miR-3667-3p hsa-miR-135b

		SwitchGear 3'UTR luciferase reporter plasmid: PIK3R2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PIK3R2 (see all 7) OriGene shRNA RFP: PIK3R2 OriGene siRNA: PIK3R2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIK3R2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3R2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3R2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PIK3R2 (NM_005027)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIK3R2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3R2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PIK3R2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIK3R2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIK3R2

Additional cDNA sequence:

BC011917.2 BC014170.2 BC070082.1 BC090249.1 NR_073517.1 X80907.1

10 DOTS entries:

DT.100786670 DT.92448454 DT.112688 DT.95119443 DT.120809034 DT.100786666 DT.100829705 DT.121450173

DT.40303890 DT.95119465

24/288 AceView cDNA sequences (see all 288):

AI885397 BU196304 BQ681260 CA952441 AW168551 BQ880915 BU190893 AI692235

BF980333 BQ680415 BQ677884 BX442248 AI355747 AA342109 AA485731 NM_005027

BU838244 AI870794 BQ676382 BM551554 BM263834 BC014170 BQ924011 AW014221

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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PIK3R2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGGGTTTTG

About this image
See PIK3R2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PIK3R2

SOURCE GeneReport for Unigene cluster: Hs.371344

SABiosciences Expression via Pathway-Focused PCR Arrays including PIK3R2 (see all 6):

mTOR Signaling in human mouse rat

Insulin Signaling Pathway in human mouse rat

PI3K-AKT Signaling Pathway in human mouse rat

EGF / PDGF Signaling Pathway in human mouse rat

VEGF Signaling in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PIK3R2 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PIK3R2¹	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	73.01(n) 74.19(a)		771142 XM_001233340.2 XP_001233341.2
lizard (Anolis carolinensis)	Reptilia	PIK3R2⁶ --	--	76(a) 70(a)	many ↔ many many ↔ many	AAWZ02040215(987-6935) AAWZ02041587(1090-4649)
zebrafish (Danio rerio)	Actinopterygii	pik3r2¹	phosphoinositide-3-kinase, regulatory subunit, polypeptide more	64.71(n) 63.81(a)		404211 NM_212822.1 NP_997987.1
fruit fly (Drosophila melanogaster)	Insecta	Pi3K21B⁶	Pi3K21B	29(a)	possible ortholog	2L(297880-305233)
worm (Caenorhabditis elegans)	Secernentea	aap-1⁶	phosphoinositide kinase AdAPter subunit family mem...	20(a)	1 → many	I(5107844-5110167)

ENSEMBL Gene Tree for PIK3R2 (if available)
TreeFam Gene Tree for PIK3R2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PIK3R2 gene

PIK3R3² PIK3R1²

4 SIMAP similar genes for PIK3R2 using alignment to 6 protein entries: P85B_HUMAN (see all proteins):

DKFZp686P05226 PIK3R1 PIK3R3 DKFZp686F1293

PIK3R2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs58695150^1,2	C,	--	17825849(+)	`NNNNAA/C/TTCTGC`	1	--	us2k¹		2		CSA WA	119
rs75430718^1,2		--	17826063(+)	`CATGGC/TTCAAA`	1	--	us2k¹		2		CSA WA	120
rs192415087^1,2		--	18262238(+)	`TGGGCA/GTTGTC`	1	--	ut3¹		0	--	--	--	--
rs184302360^1,2		--	18262254(+)	`GGGAGC/GTTGAA`	1	--	ut3¹		0	--	--	--	--
rs150555522^1,2		--	18262420(+)	`TGGAGC/GGTAGA`	1	--	ut3¹		0	--	--	--	--
rs12977216^1,2	C,F,	--	18262670(+)	`AGCCTC/GCTGCT`	1	--	ds500¹		3		NA	6
rs116755954^1,2	F,	--	18262792(+)	`CTGTAA/GCCCAG`	1	--	ds500¹		1		WA	118
rs142843133^1,2	C,	--	18262939(+)	`GGGCGG/TATCTC`	1	--	ds500¹		0	--	--	--	--
rs190415956^1,2		--	18262971(+)	`CACCCC/TGACCA`	1	--	ds500¹		0	--	--	--	--
rs60438396^1,2	C	--	18274639(+)	`AAACAAATAAA AACA/-GAAAT`	1	--	int¹		1		NA	2

HapMap Linkage Disequilibrium report for PIK3R2 (18263928 - 18281343 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PIK3R2
2 CNVs: 5093 5092
Human Gene Mutation Database (HGMD): PIK3R2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PIK3R2 for disorders           About GeneDecksing

OMIM gene information: 603157    OMIM disorders: --

20/39 diseases for PIK3R2 (see all 39):    About MalaCards

wiskott-aldrich syndrome myeloid leukemia chronic myeloid leukemia acute myeloid leukemia

insulin resistance kaposi's sarcoma renal cell carcinoma cblc

chagas disease colon carcinoma multiple myeloma polycythemia

hepatitis c trypanosomiasis toxoplasmosis gout

measles aldosteronism endometrial cancer myeloma

1 Novoseek disease relationship for PIK3R2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
colon carcinoma	39.2	2	9822674 (1), 11042696 (1)

Human Genome Epidemiology (HuGE) Navigator: PIK3R2 (4 documents)

Export disorders for PIK3R2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PIK3R2 gene, integrated from 9 sources (see all 141):
(articles sorted by number of sources associating them with PIK3R2)

Utopia: connect your pdf to the dynamic
world of online information

Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta. (PubMed id 1314371)^{1, 2, 3} Volinia S.... Waterfield M.D. (1992)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme. (PubMed id 9582025)^{1, 2} Janssen J.W.G.... Schulz A.S. (1998)
Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site. (PubMed id 9178760)^{1, 2} Braunger J....Janssen J.W. (1997)
p85beta phosphoinositide 3-kinase regulates CD28 coreceptor function. (PubMed id 19190244)^{1, 9} AlcA!zar I....Carrera A.C. (2009)
Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system. (PubMed id 1334406)^{1, 9} Gout I....Waterfield M.D. (1992)
Formation of signal transfer complexes between stem cell and platelet-derived growth factor receptors and SH2 domain proteins in vitro. (PubMed id 7537096)^{1, 9} Herbst R....Ullrich A. (1995)
De novo germline and postzygotic mutations in AKT3, PI K3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes. (PubMed id 22729224)¹ Riviere J.B....Dobyns W.B. (2012)
The miR-126 regulates angiopoietin-1 signaling and ves sel maturation by targeting p85b. (PubMed id 22867989)¹ Sessa R....Primo L. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5296	HGNC: 8980	AceView: PIK3R2	Ensembl:ENSG00000105647	euGenes: HUgn5296
ECgene: PIK3R2	Kegg: 5296	H-InvDB: PIK3R2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PIK3R2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PIK3R2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PIK3R2 gene:
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PIK3R2 Gene

phosphoinositide-3-kinase, regulatory subunit 2 (beta)

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PIK3R2 Gene

phosphoinositide-3-kinase, regulatory subunit 2 (beta)

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