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Aliases for PIK3R2 Gene

Aliases for PIK3R2 Gene

  • Phosphoinositide-3-Kinase, Regulatory Subunit 2 (Beta) 2 3
  • Phosphatidylinositol 3-Kinase 85 KDa Regulatory Subunit Beta 3 4
  • PtdIns-3-Kinase Regulatory Subunit P85-Beta 3 4
  • PI3K Regulatory Subunit Beta 3 4
  • PI3-Kinase Subunit P85-Beta 3 4
  • MPPH 3 6
  • Phosphatidylinositol 3-Kinase, Regulatory Subunit, Polypeptide 2 (P85 Beta) 3
  • Phosphatidylinositol 3-Kinase Regulatory Subunit Beta 3
  • PtdIns-3-Kinase Regulatory Subunit Beta 4
  • PI3-Kinase Regulatory Subunit Beta 4
  • P85-BETA 3
  • MPPH1 3
  • P85B 3
  • P85 3

External Ids for PIK3R2 Gene

Previous GeneCards Identifiers for PIK3R2 Gene

  • GC19P018760
  • GC19P018658
  • GC19P018108
  • GC19P018127
  • GC19P018089
  • GC19P018263
  • GC19P017828

Summaries for PIK3R2 Gene

Entrez Gene Summary for PIK3R2 Gene

  • Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for PIK3R2 Gene

PIK3R2 (Phosphoinositide-3-Kinase, Regulatory Subunit 2 (Beta)) is a Protein Coding gene. Diseases associated with PIK3R2 include megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 and megalencephaly - polymicrogyria - postaxial polydactyly - hydrocephalus. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include receptor tyrosine kinase binding and phosphatidylinositol 3-kinase regulator activity. An important paralog of this gene is PIK3R3.

UniProtKB/Swiss-Prot for PIK3R2 Gene

  • Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).

Tocris Summary for PIK3R2 Gene

  • PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes (C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI 3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3R2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIK3R2 Gene

Genomics for PIK3R2 Gene

Regulatory Elements for PIK3R2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PIK3R2 Gene

Start:
18,153,118 bp from pter
End:
18,170,540 bp from pter
Size:
17,423 bases
Orientation:
Plus strand

Genomic View for PIK3R2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIK3R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIK3R2 Gene

Proteins for PIK3R2 Gene

  • Protein details for PIK3R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00459-P85B_HUMAN
    Recommended name:
    Phosphatidylinositol 3-kinase regulatory subunit beta
    Protein Accession:
    O00459
    Secondary Accessions:
    • Q5EAT5
    • Q9UPH9

    Protein attributes for PIK3R2 Gene

    Size:
    728 amino acids
    Molecular mass:
    81545 Da
    Quaternary structure:
    • Heterodimer of a regulatory subunit PIK3R2 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD) (PubMed:23604317). Interacts with AXL (PubMed:9178760). Interacts with FLT1 (tyrosine-phosphorylated) and FLT4 (tyrosine-phosphorylated) (PubMed:9600074, PubMed:15102829). Interacts with NYAP1, NYAP2 and MYO16 (By similarity). Interacts with FBXL2; PIK3R2 is a substrate of the SCF(FBXL2) complex (PubMed:23604317). Interacts with PTPN13; dephosphorylates PIK3R2 (PubMed:23604317). Interacts with XBP1 isoform 2; the interaction is direct and induces translocation of XBP1 isoform 2 into the nucleus in a ER stress-and/or insulin-dependent but PI3K-independent manner (By similarity). Interacts with PIK3R1; the interaction is dissociated in an insulin-dependent manner (By similarity).

    Three dimensional structures from OCA and Proteopedia for PIK3R2 Gene

neXtProt entry for PIK3R2 Gene

Proteomics data for PIK3R2 Gene at MOPED

Post-translational modifications for PIK3R2 Gene

  • Phosphorylated in response to signaling from activated receptor-type protein kinases (PubMed:19690332, PubMed:20068231). Dephosphorylated by PTPRJ (PubMed:18348712). Dephosphorylated at Tyr-655 by PTPN13. Phosphorylation of Tyr-655 impairs while its dephosphorylation promotes interaction with FBXL2 and SCF(FBXL2)-mediated polyubiquitination (PubMed:23604317).
  • Ubiquitinated. Polyubiquitination by the SCF(FBXL2) complex probably promotes proteasomal degradation of PIK3R2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIK3R2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PIK3R2 (PI 3-Kinase p85 beta)
  • Cell Signaling Technology (CST) Antibodies for PIK3R2 (PIK3R2)

No data available for DME Specific Peptides for PIK3R2 Gene

Domains for PIK3R2 Gene

Gene Families for PIK3R2 Gene

HGNC:
  • SH2D :SH2 domain containing

Graphical View of Domain Structure for InterPro Entry

O00459

UniProtKB/Swiss-Prot:

P85B_HUMAN :
  • O00459
Domain:
  • The SH2 2 domain is required for interaction with FBXL2 and PTPN13.
  • Contains 1 Rho-GAP domain.
  • Contains 2 SH2 domains.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the PI3K p85 subunit family.
genes like me logo Genes that share domains with PIK3R2: view

Function for PIK3R2 Gene

Molecular function for PIK3R2 Gene

GENATLAS Biochemistry:
phosphatidylinositol 3-kinase (p85 beta),regulatory subunit,class IA adaptor molecule associating 110-120kDa catalytic subunits,interacting with tyrosine kinase (signal transduction),interacting with inositol polyphosphatase 4-phosphatase and inositol polyphosphatase 5-phosphatase,expressed in B and T cells
UniProtKB/Swiss-Prot Function:
Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).

Gene Ontology (GO) - Molecular Function for PIK3R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16273093
GO:0016303 contributes_to 1-phosphatidylinositol-3-kinase activity ISS --
GO:0019903 protein phosphatase binding IPI 23604317
GO:0030971 receptor tyrosine kinase binding IPI 10627473
GO:0035014 phosphatidylinositol 3-kinase regulator activity --
genes like me logo Genes that share ontologies with PIK3R2: view

Phenotypes for PIK3R2 Gene

genes like me logo Genes that share phenotypes with PIK3R2: view

Animal Models for PIK3R2 Gene

MGI Knock Outs for PIK3R2:

miRNA for PIK3R2 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIK3R2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PIK3R2 Gene

Localization for PIK3R2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIK3R2 Gene COMPARTMENTS Subcellular localization image for PIK3R2 gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for PIK3R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus ISS --
GO:0005829 cytosol TAS --
GO:0005942 phosphatidylinositol 3-kinase complex IBA --
genes like me logo Genes that share ontologies with PIK3R2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PIK3R2 Gene

Pathways for PIK3R2 Gene

SuperPathways for PIK3R2 Gene

Superpath Contained pathways
1 PI-3K cascade
2 Signaling by FGFR
3 IL-2 Pathway
4 IL-9 Signaling Pathways
5 Apoptotic Pathways in Synovial Fibroblasts
genes like me logo Genes that share pathways with PIK3R2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for PIK3R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001678 cellular glucose homeostasis ISS --
GO:0006644 phospholipid metabolic process TAS --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0007165 signal transduction --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with PIK3R2: view

Compounds for PIK3R2 Gene

(5) Tocris Compounds for PIK3R2 Gene

Compound Action Cas Number
740 Y-P Cell-permeable PI 3-kinase activator [1236188-16-1]
PF 05212384 Potent and selective dual PI 3-K/mTOR inhibitor [1197160-78-3]
PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK [371935-79-4]
PI 828 PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130) [942289-87-4]
Quercetin Non-selective PI 3-kinase inhibitor [117-39-5]

(14) ApexBio Compounds for PIK3R2 Gene

Compound Action Cas Number
A66 P110α inhibitor [1166227-08-2]
AS-605240 Potent and selective PI 3-Kγ inhibitor [648450-29-7]
BEZ235 Tosylate MTOR/P13K inhibitor [1028385-32-1]
GSK2636771 PIK3 inhibitor [1372540-25-4]
HS-173 [1276110-06-5]
IC-87114 PI3Kδ inhibitor [371242-69-2]
IPI-145 (INK1197) PI3K-δ/PI3K-γ inhibitor [1201438-56-3]
LY 294002 Potent PI3K inhibitor [154447-36-6]
PI-3065 P110δkinase inhibitor [955977-50-1]
SAR245409 (XL765) mTOR/PI3K inhibitor [1349796-36-6]
TG100-115 PI3Kγ/PI3Kδ inhibitor [677297-51-7]
TG100713 [925705-73-3]
Wortmannin "PI3K inhibitor,selective and irreversible" [19545-26-7]
XL147 "PI3K inhibitor,selective and reversible" [956958-53-5]

(1) Drugbank Compounds for PIK3R2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Isoproterenol
  • Epinephrine Isopropyl Homolog
7683-59-2 target agonist

(3) Novoseek inferred chemical compound relationships for PIK3R2 Gene

Compound -log(P) Hits PubMed IDs
phosphatidylinositol 73.2 13
phosphoinositide 55.5 3
threonine 25.9 1
genes like me logo Genes that share compounds with PIK3R2: view

Transcripts for PIK3R2 Gene

Unigene Clusters for PIK3R2 Gene

Phosphoinositide-3-kinase, regulatory subunit 2 (beta):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIK3R2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIK3R2 Gene

No ASD Table

Relevant External Links for PIK3R2 Gene

GeneLoc Exon Structure for
PIK3R2
ECgene alternative splicing isoforms for
PIK3R2

Expression for PIK3R2 Gene

mRNA expression in normal human tissues for PIK3R2 Gene

Protein differential expression in normal tissues for PIK3R2 Gene

This gene is overexpressed in Breast (38.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIK3R2 Gene

SOURCE GeneReport for Unigene cluster for PIK3R2 Gene Hs.371344

genes like me logo Genes that share expressions with PIK3R2: view

Expression partners for PIK3R2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PIK3R2 Gene

Orthologs for PIK3R2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PIK3R2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PIK3R2 35
  • 89.86 (n)
  • 96.63 (a)
PIK3R2 36
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PIK3R2 35
  • 90.49 (n)
  • 96.78 (a)
-- 36
  • 97 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Pik3r2 35
  • 84.15 (n)
  • 89.59 (a)
Pik3r2 16
Pik3r2 36
  • 90 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia PIK3R2 35
  • 99.86 (n)
  • 100 (a)
PIK3R2 36
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pik3r2 35
  • 83.26 (n)
  • 88.75 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
OneToMany
chicken
(Gallus gallus)
Aves PIK3R2 35
  • 73.12 (n)
  • 74.36 (a)
-- 36
  • 71 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 76 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pik3r2 35
  • 62.25 (n)
  • 64.32 (a)
zebrafish
(Danio rerio)
Actinopterygii pik3r2 35
  • 64.94 (n)
  • 63.98 (a)
pik3r2 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pi3K21B 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea aap-1 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for PIK3R2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIK3R2 Gene

ENSEMBL:
Gene Tree for PIK3R2 (if available)
TreeFam:
Gene Tree for PIK3R2 (if available)

Paralogs for PIK3R2 Gene

Paralogs for PIK3R2 Gene

Selected SIMAP similar genes for PIK3R2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PIK3R2: view

Variants for PIK3R2 Gene

Sequence variations from dbSNP and Humsavar for PIK3R2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs13006 -- 18,169,835(+) CCTCC(A/T)AACCC utr-variant-3-prime, nc-transcript-variant
rs124216 -- 18,154,876(+) gtttg(C/G)gacca intron-variant
rs273269 -- 18,168,828(+) CTGAG(C/T)GGCAA synonymous-codon, reference, nc-transcript-variant
rs273270 -- 18,168,716(+) CGCCC(C/G)CCACC intron-variant
rs273271 -- 18,168,329(+) AGCCA(C/G)GTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIK3R2 Gene

Variant ID Type Subtype PubMed ID
nsv833773 CNV Loss 17160897
dgv3771n71 CNV Loss 21882294
dgv3772n71 CNV Loss 21882294
nsv911244 CNV Gain 21882294
dgv3773n71 CNV Loss 21882294
nsv833774 CNV Loss 17160897
nsv833775 CNV Loss 17160897
dgv3774n71 CNV Loss 21882294
nsv2429 CNV Loss 18451855
nsv911254 CNV Loss 21882294
dgv3775n71 CNV Loss 21882294
nsv911256 CNV Loss 21882294
dgv3776n71 CNV Loss 21882294
esv2677454 CNV Deletion 23128226

Relevant External Links for PIK3R2 Gene

HapMap Linkage Disequilibrium report
PIK3R2
Human Gene Mutation Database (HGMD)
PIK3R2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIK3R2 Gene

Disorders for PIK3R2 Gene

(1) OMIM Diseases for PIK3R2 Gene (603157)

UniProtKB/Swiss-Prot

P85B_HUMAN
  • Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 (MPPH1) [MIM:603387]: A syndrome characterized by megalencephaly, hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome. {ECO:0000269 PubMed:22729224}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) Novoseek inferred disease relationships for PIK3R2 Gene

Disease -log(P) Hits PubMed IDs
colon carcinoma 39.2 2

Relevant External Links for PIK3R2

Genetic Association Database (GAD)
PIK3R2
Human Genome Epidemiology (HuGE) Navigator
PIK3R2
genes like me logo Genes that share disorders with PIK3R2: view

No data available for University of Copenhagen DISEASES and Genatlas for PIK3R2 Gene

Publications for PIK3R2 Gene

  1. Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta. (PMID: 1314371) Volinia S. … Waterfield M.D. (Oncogene 1992) 2 3 4
  2. Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system. (PMID: 1334406) Gout I. … Waterfield M.D. (Biochem. J. 1992) 3 23
  3. Formation of signal transfer complexes between stem cell and platelet-derived growth factor receptors and SH2 domain proteins in vitro. (PMID: 7537096) Herbst R. … Ullrich A. (Biochemistry 1995) 3 23
  4. Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site. (PMID: 9178760) Braunger J. … Janssen J.W. (Oncogene 1997) 3 4
  5. An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme. (PMID: 9582025) Janssen J.W.G. … Schulz A.S. (Oncogene 1998) 3 4

Products for PIK3R2 Gene

Sources for PIK3R2 Gene

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