Aliases for PIK3R2 Gene
- Phosphoinositide-3-Kinase, Regulatory Subunit 2 (Beta) 2 3
- Phosphatidylinositol 3-Kinase 85 KDa Regulatory Subunit Beta 3 4
- PtdIns-3-Kinase Regulatory Subunit P85-Beta 3 4
- PI3K Regulatory Subunit Beta 3 4
- PI3-Kinase Subunit P85-Beta 3 4
- MPPH 3 6
- Phosphatidylinositol 3-Kinase, Regulatory Subunit, Polypeptide 2 (P85 Beta) 3
- Phosphatidylinositol 3-Kinase Regulatory Subunit Beta 3
External Ids for PIK3R2 Gene
Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012]
GeneCards Summary for PIK3R2 Gene
PIK3R2 (Phosphoinositide-3-Kinase, Regulatory Subunit 2 (Beta)) is a Protein Coding gene. Diseases associated with PIK3R2 include megalencephaly - polymicrogyria - postaxial polydactyly - hydrocephalus and megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include receptor tyrosine kinase binding and phosphatidylinositol 3-kinase regulator activity. An important paralog of this gene is PIK3R3.
UniProtKB/Swiss-Prot for PIK3R2 Gene
Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).
PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the 3OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes (C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI 3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.