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PIK3R1 Gene

protein-coding   GIFtS: 72
GCID: GC05P067511

Phosphoinositide-3-Kinase, Regulatory Subunit 1 (Alpha)

  See PIK3R1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phosphoinositide-3-Kinase, Regulatory Subunit 1 (Alpha)1 2     p85-ALPHA2
GRB12 3 5     Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha2
Phosphatidylinositol 3-Kinase 85 KDa Regulatory Subunit Alpha2 3     Phosphatidylinositol 3-Kinase, Regulatory Subunit, Polypeptide 1 (P85
Alpha)2
PtdIns-3-Kinase Regulatory Subunit Alpha2 3     Phosphatidylinositol 3-Kinase-Associated P-85 Alpha2
PI3-Kinase Subunit P85-Alpha2 3     Phosphoinositide-3-Kinase Regulatory Subunit2
PI3K Regulatory Subunit Alpha2 3     PI3-Kinase Regulatory Subunit Alpha3
AGM72 5     PtdIns-3-Kinase Regulatory Subunit P85-Alpha3
p852     SHORT5

External Ids:    HGNC: 89791   Entrez Gene: 52952   Ensembl: ENSG000001456757   OMIM: 1718335   UniProtKB: P279863   

Export aliases for PIK3R1 gene to outside databases

Previous GC identifers: GC05P067677 GC05P069074 GC05P067492 GC05P067538 GC05P067558 GC05P064479


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PIK3R1 Gene:
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position.
The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene
encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic
actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing
of this gene results in four transcript variants encoding different isoforms. (provided by RefSeq, Jun 2011)

GeneCards Summary for PIK3R1 Gene:
PIK3R1 (phosphoinositide-3-kinase, regulatory subunit 1 (alpha)) is a protein-coding gene. Diseases associated with PIK3R1 include short syndrome, and agammaglobulinemia 7, autosomal recessive. GO annotations related to this gene include protein phosphatase binding and 1-phosphatidylinositol binding. An important paralog of this gene is PIK3R2.

UniProtKB/Swiss-Prot: P85A_HUMAN, P27986
Function: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter,
mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated
increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in
signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in
ITGB2 signaling

summary for PIK3R1 Gene:
PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the
3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of
cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell
migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric
consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and
delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst
p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have
recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes
(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI
3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to
play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3R1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PIK3R1 gene promoter:
         AP-1   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): PIK3R1 promoter sequence
   Search Chromatin IP Primers for PIK3R1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIK3R1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.1   Ensembl cytogenetic band:  5q13.1   HGNC cytogenetic band: 5q13.1

PIK3R1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIK3R1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P067511:  view genomic region     (about GC identifiers)

Start:
67,511,548 bp from pter      End:
67,597,649 bp from pter
Size:
86,102 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: P85A_HUMAN, P27986 (See protein sequence)
Recommended Name: Phosphatidylinositol 3-kinase regulatory subunit alpha  
Size: 724 amino acids; 83598 Da
Subunit: Heterodimer of a regulatory subunit PIK3R1 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD).
Interacts with FER. Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated). Interacts with PTK2/FAK1
(By similarity). Interacts with phosphorylated TOM1L1. Interacts with phosphorylated LIME1 upon TCR and/or BCR
activation. Interacts with SOCS7. Interacts with RUFY3. Interacts (via SH2 domain) with CSF1R (tyrosine
phosphorylated). Interacts with LYN (via SH3 domain); this enhances enzyme activity (By similarity). Interacts
with phosphorylated LAT, LAX1 and TRAT1 upon TCR activation. Interacts with CBLB. Interacts with HIV-1 Nef to
activate the Nef associated p21-activated kinase (PAK). This interaction depends on the C-terminus of both
proteins and leads to increased production of HIV. Interacts with HCV NS5A. The SH2 domains interact with the
YTHM motif of phosphorylated INSR in vitro. Also interacts with tyrosine-phosphorylated IGF1R in vitro. Interacts
with CD28 and CD3Z upon T-cell activation. Interacts with IRS1 and phosphorylated IRS4, as well as with NISCH and
HCST. Interacts with FASLG, KIT and BCR. Interacts with AXL, FGFR1, FGFR2, FGFR3 and FGFR4 (phosphorylated).
Interacts with FGR and HCK. Interacts with PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated).
Interacts with ERBB4 (phosphorylated). Interacts with NTRK1 (phosphorylated upon ligand-binding)
Selected PDB 3D structures from and Proteopedia for PIK3R1 (see all 21):
1A0N (3D)        1AZG (3D)        1H9O (3D)        1PBW (3D)        1PHT (3D)        1PIC (3D)    
Secondary accessions: B3KT19 D3DWA0 E7EX19 Q15747 Q4VBZ7 Q53EM6 Q8IXA2 Q8N1C5
Alternative splicing: 5 isoforms:  P27986-1   P27986-2   P27986-3   P27986-4   P27986-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PIK3R1: NX_P27986

Explore proteomics data for PIK3R1 at MOPED

Post-translational modifications: 

  • Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with
    CD28 and CD3Z upon T-cell activation1
  • Phosphorylated. Tyrosine phosphorylated in response to signaling by FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylated
    by CSF1R. Phosphorylated by ERBB4. Phosphorylated on tyrosine residues by TEK/TIE2. Dephosphorylated by PTPRJ.
    Phosphorylated by PIK3CA at Ser-608; phosphorylation is stimulated by insulin and PDGF. The relevance of
    phosphorylation by PIK3CA is however unclear (By similarity). Phosphorylated in response to KIT and KITLG/SCF.
    Phosphorylated by FGR1
  • Ubiquitination2 at Lys419
  • Modification sites at PhosphoSitePlus

  • See PIK3R1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001229395.1  NP_852556.2  NP_852664.1  NP_852665.1  

    ENSEMBL proteins: 
     ENSP00000428056   ENSP00000429277   ENSP00000428566   ENSP00000430126   ENSP00000429766  
     ENSP00000323512   ENSP00000431058   ENSP00000338554   ENSP00000430424   ENSP00000429156  
     ENSP00000430098   ENSP00000379855   ENSP00000274335  
    Reactome Protein details: P27986

    PIK3R1 Human Recombinant Protein Products:

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    Novus Biologicals PIK3R1 Proteins
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    Browse Sino Biological Recombinant Proteins
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    ProSpec Recombinant Protein for PIK3R1
    Cloud-Clone Corp. Proteins for PIK3R1

     
    Search eBioscience for Proteins for PIK3R1 

     
    antibodies-online proteins for PIK3R1 (11 products) 

     
    antibodies-online peptides for PIK3R1

    PIK3R1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PIK3R1
    R&D Systems Antibodies for PIK3R1 (PI 3-Kinase p85 alpha)
    Cell Signaling Technology (CST) Antibodies for PIK3R1 
    OriGene Antibodies for PIK3R1
    OriGene Custom Antibody Services for PIK3R1
    Novus Biologicals PIK3R1 Antibodies
    Abcam antibodies for PIK3R1 (O00459, Q92569, P27986)
    Cloud-Clone Corp. Antibodies for PIK3R1
    ThermoFisher Antibody for PIK3R1
    antibodies-online antibodies for PIK3R1 (166 products) 

    PIK3R1 Assay Products:

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    Cloud-Clone Corp. ELISAs for PIK3R1
    Cloud-Clone Corp. CLIAs for PIK3R1
    Search eBioscience for ELISAs for PIK3R1 
    antibodies-online kits for PIK3R1 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    Selected InterPro protein domains (see all 6):
     IPR008936 Rho_GTPase_activation_prot
     IPR001720 PI3kinase_P85
     IPR001452 SH3_domain
     IPR011511 SH3_2
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry P27986

    ProtoNet protein and cluster: P27986

    3 Blocks protein domains:
    IPB000198 RhoGAP domain
    IPB000980 SH2 domain signature
    IPB001720 PI3 kinase P85 regulatory subunit signature


    UniProtKB/Swiss-Prot: P85A_HUMAN, P27986
    Domain: The SH3 domain mediates the binding to CBLB, and to HIV-1 Nef
    Similarity: Belongs to the PI3K p85 subunit family
    Similarity: Contains 1 Rho-GAP domain
    Similarity: Contains 2 SH2 domains
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with PIK3R1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P85A_HUMAN, P27986
    Function: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter,
    mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated
    increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in
    signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in
    ITGB2 signaling

         Genatlas biochemistry entry for PIK3R1:
    phosphatidylinositol 3-kinase (p85 alpha),regulatory subunit,class IA adaptor molecule associating 110-120kDa
    catalytic subunits,interacting with tyrosine kinase (signal transduction),interacting with inositol
    polyphosphatase 4-phosphatase and inositol polyphosphatase 5-phosphatase forming complex with SHIP (INPP5D) and
    SHP2 (PTPN11),expressed in B and T cells,also interacting with IRS1 and playing a potential role in glucose
    homeostasis

         Gene Ontology (GO): Selected molecular function terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005068transmembrane receptor protein tyrosine kinase adaptor activity ISS--
    GO:0005158insulin receptor binding IPI7537849
    GO:0005159insulin-like growth factor receptor binding IPI7541045
    GO:0005168neurotrophin TRKA receptor binding IPI15488758
         
    Find genes that share ontologies with PIK3R1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PIK3R1:
     Increased cell death in breast  Increased homologous recombina 

         13 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Pik3r1):
     adipose tissue  cardiovascular system  cellular  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  muscle 
     no phenotypic analysis  normal  tumorigenesis 

    Find genes that share phenotypes with PIK3R1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PIK3R1: Pik3r1tm2Dfr Pik3r1tm1Tka Pik3r1tm1Dfr Pik3r1tm1Khn

       genOway: Develop your customized and physiologically relevant rodent model for PIK3R1

    miRNA
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    miRTarBase miRNAs that target PIK3R1:
    hsa-mir-21-5p (MIRT030860), hsa-mir-376a-3p (MIRT006724), hsa-mir-29a-3p (MIRT004103), hsa-let-7a-5p (MIRT052505)

    Block miRNA regulation of human, mouse, rat PIK3R1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PIK3R1 (see all 114):
    hsa-miR-607 hsa-miR-642a hsa-miR-361-5p hsa-miR-3607-3p hsa-miR-376b hsa-miR-15a hsa-miR-199a-3p hsa-miR-106a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PIK3R1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PIK3R1

    Clone
    Products:
         
    OriGene clones in human, mouse for PIK3R1 (see all 18)
    OriGene ORF clones in mouse, rat for PIK3R1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PIK3R1 (NM_181523)
    Sino Biological Human cDNA Clone for PIK3R1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIK3R1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3R1
    Addgene plasmids for PIK3R1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3R1

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-11967) for PIK3R1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane4

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0005942phosphatidylinositol 3-kinase complex ISS--

    Find genes that share ontologies with PIK3R1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PIK3R1 About   (see all 219)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1IL-9 Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-9 Signaling Pathway0.42
    IL-7 Signaling Pathways0.90
    Immune response IL 9 signaling pathway0.42
    IL-21 Signaling Pathways0.90
    IL-7 Signaling Pathway0.40
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    Development Thrombopoietin regulated cell processes0.38
    2Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    VEGF signaling pathway0.39
    Immune response BCR pathway0.43
    VEGF - VEGF R2 Signaling Pathways0.35
    Fc epsilon RI signaling pathway0.41
    Fc-epsilon receptor I signaling in mast cells0.34
    3Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Cell adhesion PLAU signaling0.35
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Transcription PPAR Pathway0.34
    Transcription Receptor mediated HIF regulation0.51
    Development Growth hormone signaling via PI3K AKT and MAPK cascades0.34
    Translation Regulation activity of EIF20.47
    mTOR signaling pathway0.34
    4Immune response IL 23 signaling pathway
    Immune response IL 23 signaling pathway0.41
    IL23-mediated signaling events0.38
    Development PDGF signaling via STATs and NF kB0.41
    Angiopoietin-TIE2 Signaling0.36
    Development Angiopoietin Tie2 signaling0.38
    Angiopoietin receptor Tie2-mediated signaling0.32
    Immune response IL 10 signaling pathway0.38
    5Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    Immune response IL 4 signaling pathway0.39


    Find genes that share SuperPaths with PIK3R1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for PIK3R1 (see all 12)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PIK3R1 (see all 131)
        Fc-GammaR Pathway
    Toll-Like Receptors Pathway
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    JNK Pathway

    1 Cell Signaling Technology (CST) Pathway for PIK3R1
        PI3K / Akt Signaling

    Selected Tocris Bioscience Pathways for PIK3R1 (see all 9)
        Akt Pathway
    Insulin Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    Toll-like Receptor Pathway

    Selected GeneGo (Thomson Reuters) Pathways for PIK3R1 (see all 67)
        Development CNTF receptor signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway
    Signal transduction AKT signaling
    Immune response IL-9 signaling pathway

    Selected BioSystems Pathways for PIK3R1 (see all 93)
        MicroRNAs in cardiomyocyte hypertrophy
    Focal Adhesion
    Apoptosis
    EGFR1 Signaling Pathway
    Insulin Signaling


    Selected Reactome Pathways for PIK3R1 (see all 31)
        Nephrin interactions
    G alpha (12/13) signalling events
    Costimulation by the CD28 family
    GP1b-IX-V activation signalling
    Regulation of signaling by CBL

    3 PharmGKB Pathways for PIK3R1
        Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Sorafenib Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for PIK3R1) (see all 61):
        ErbB signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    Chemokine signaling pathway
    HIF-1 signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PIK3R1 (see all 10): 
              mTOR Signaling in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              VEGF Signaling in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Diabetes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PIK3R1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PIK3R1 (P279861, 2, 3 ENSP000002743354) via UniProtKB, MINT, STRING, and/or I2D (see all 669)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB3P218601, 2, 3, ENSP000002671014EBI-79464,EBI-720706 MINT-74605 MINT-74600 MINT-74616 MINT-74613 MINT-74601 MINT-74612 MINT-74615 MINT-74597 MINT-74602 MINT-74596 MINT-74614 MINT-74611 MINT-74604 MINT-74617 MINT-74603 I2D: score=7 STRING: ENSP00000267101
    PDGFRBP096191, 2, 3, ENSP000002617994EBI-79464,EBI-641237 MINT-8029783 MINT-8029948 MINT-8029933 MINT-8029858 MINT-8030936 MINT-8031128 MINT-8029888 MINT-8031173 MINT-8029798 MINT-8030966 MINT-8030997 MINT-8031204 MINT-8029963 MINT-8030981 MINT-8031012 MINT-8031113 MINT-8031053 MINT-8031143 I2D: score=6 STRING: ENSP00000261799
    CBLP226811, 2, 3, ENSP000002640334EBI-79464,EBI-518228 MINT-50733 MINT-68500 MINT-14996 MINT-7103607 MINT-65975 MINT-7214865 MINT-50723 MINT-68494 MINT-65977 MINT-8036115 MINT-8036175 MINT-8028565 MINT-15294 MINT-7103683 MINT-8029727 I2D: score=5 STRING: ENSP00000264033
    IRS1P355681, 2, 3, ENSP000003048954EBI-79464,EBI-517592 MINT-8036617 MINT-8028908 MINT-8036602 MINT-8033089 MINT-8036587 MINT-8033340 MINT-8036572 MINT-8028923 MINT-8033074 MINT-68735 I2D: score=10 STRING: ENSP00000304895
    CD28P107471, 2, 3, ENSP000003248904EBI-79464,EBI-4314301 MINT-8036648 MINT-8036674 MINT-8036765 MINT-8036633 MINT-8036690 MINT-8036705 MINT-8036750 MINT-8036780 I2D: score=4 STRING: ENSP00000324890
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 39):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001953negative regulation of cell-matrix adhesion IEA--
    GO:0006468protein phosphorylation IEA--
    GO:0006644phospholipid metabolic process TAS--
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0007165signal transduction ----

    Find genes that share ontologies with PIK3R1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for PIK3R1 (see all 28)     About this table
    CompoundAction CAS #
    A66highly specific and selective p110alpha inhibitor[1166227-08-2]
    AS-605240Potent and selective inhibitor of PI 3-kinase beta.[648450-29-7]http://www.apexbt.com/search.php?catalog=A5176
    AZD6482Potent and selective inhibitor of PI 3-kinase beta[1173900-33-8]
    BEZ235 (NVP-BEZ235)imidazoquinoline derivative inhibiting both PI3K and mTOR kinases[915019-65-7]
    BKM120small-molecule inhibitor of pan-Class I PI3K[944396-07-0]
    BYL-719selective PI3Kalfa inhibitor[1217486-61-7]
    CAL-101 (Idelalisib, GS-1101)p110delta selective PI3K inhibitor[870281-82-6]
    CAL-130novel PI3K inhibitor. [1431697-74-3]
    CUDC-907dual PI3K and HDAC inhibitor[1339928-25-4]
    CZC24832selective inhibitor of PI3Kgamma[1159824-67-5]

    Compounds for PIK3R1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CZC 24832Selective inhibitor of PI 3-Kinase gamma[1159824-67-5]
    QuercetinNon-selective PI 3-kinase inhibitor[117-39-5]
    PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK [371935-74-9]
    AS 605240Potent and selective PI 3-kinase gamma (PI3Kgamma) inhibitor[648450-29-7]
    740 Y-PCell-permeable PI 3-kinase activator[1236188-16-1]

    2 DrugBank Compounds for PIK3R1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    IsoproterenolEpinephrine Isopropyl Homolog (see all 14)7683-59-2targetagonist15985706 15527548 15381832 15618457 15110780
    (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for PIK3R1 gene (see all 69)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 91.9 368 9054447 (6), 7961856 (4), 1372092 (3), 14683460 (3) (see all 99)
    phosphoinositide 86.5 173 11027274 (5), 14504291 (3), 18516572 (3), 19207420 (3) (see all 99)
    tyrosine 78.3 170 7678051 (3), 7509794 (3), 10358153 (3), 8816504 (3) (see all 99)
    rapamycin 70.1 38 17908691 (3), 15641016 (1), 15653324 (1), 16916489 (1) (see all 27)
    phosphotyrosine 69.1 18 15700969 (2), 1375321 (1), 8952511 (1), 9583121 (1) (see all 14)
    glycogen 68.1 32 11334418 (1), 15691882 (1), 16055672 (1), 10330191 (1) (see all 28)
    phosphatidylinositol-3,4,5-trisphosphate 65.6 11 11805146 (1), 17335807 (1), 12933652 (1), 15986137 (1) (see all 8)
    pp36 62.6 4 7544353 (2), 9541596 (1)
    threonine 55.1 15 17625596 (2), 15795286 (1), 18786649 (1), 11368419 (1) (see all 13)
    serine 54.7 28 11313980 (4), 8388374 (2), 16873706 (2), 18948408 (2) (see all 18)



    Find genes that share compounds with PIK3R1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for PIK3R1 gene (4 alternative transcripts): 
    NM_001242466.1  NM_181504.3  NM_181523.2  NM_181524.1  

    Unigene Cluster for PIK3R1:

    Phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
    Hs.132225  [show with all ESTs]
    Unigene Representative Sequence: NM_181523
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521381(uc003jva.3 uc003jvc.3 uc003jvd.3 uc003jve.3 uc021xzn.1)
    ENST00000521657 ENST00000517643 ENST00000517412 ENST00000520675 ENST00000523807
    ENST00000522084 ENST00000320694 ENST00000521409 ENST00000336483 ENST00000518292
    ENST00000517698 ENST00000518813 ENST00000519025 ENST00000523872 ENST00000520550(uc011crb.2)
    ENST00000396611 ENST00000274335
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PIK3R1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PIK3R1 (see all 114):
    hsa-miR-607 hsa-miR-642a hsa-miR-361-5p hsa-miR-3607-3p hsa-miR-376b hsa-miR-15a hsa-miR-199a-3p hsa-miR-106a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PIK3R1
    Predesigned siRNA for gene silencing in human, mouse, rat PIK3R1
    Clone
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    OriGene clones in human, mouse for PIK3R1 (see all 18)
    OriGene ORF clones in mouse, rat for PIK3R1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PIK3R1 (NM_181523)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIK3R1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3R1
    Addgene plasmids for PIK3R1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PIK3R1
    OriGene qSTAR qPCR primer pairs in human, mouse for PIK3R1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PIK3R1
      QuantiTect SYBR Green Assays in human, mouse, rat PIK3R1
      QuantiFast Probe-based Assays in human, mouse, rat PIK3R1
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11967) for PIK3R1 

    Additional mRNA sequence: 

    AF279367.1 AK000121.1 AK094785.1 AK126345.1 AK223613.1 AK294919.1 AK299743.1 BC030815.1 
    BC094795.1 JX133164.1 JX133165.1 L26969.1 L30106.1 M61906.1 U49349.1 

    17 DOTS entries:

    DT.85100648  DT.100798319  DT.99928781  DT.120820335  DT.95160311  DT.92425727  DT.120820321  DT.92425719 
    DT.100798321  DT.92425724  DT.95268235  DT.75176710  DT.95207719  DT.120820311  DT.120820329  DT.95268236 
    DT.91688907 

    Selected AceView cDNA sequences (see all 295):

    Z44767 AA091104 AV709741 NM_181504 AF279367 BM980356 Z41711 AI124626 
    AI560484 AI424553 AI190793 F11518 R44393 BM917201 AK126345 F11517 
    BQ773891 NM_181523 CF994983 T33598 AI468333 Z44713 F09179 AA463460 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PIK3R1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19a ·
    SP1:                                      -     -     -     -     -           -     -                                                                           
    SP2:                                                  -     -     -           -     -                                                                           
    SP3:                                                              -           -     -                                                                           
    SP4:                                                                          -     -                                                                           
    SP5:                                                                                                                                                            

    ExUns: 19b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for PIK3R1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PIK3R1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGATAGCATT
    PIK3R1 Expression
    About this image


    PIK3R1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Bone marrow-derived hematopoietic stem cells (family)
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
    PIK3R1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIK3R1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.132225

    UniProtKB/Swiss-Prot: P85A_HUMAN, P27986
    Tissue specificity: Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac
    muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PIK3R1 (see all 10): 
              mTOR Signaling in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              VEGF Signaling in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Diabetes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PIK3R1
    OriGene qSTAR qPCR primer pairs in human, mouse for PIK3R1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PIK3R1
    QuantiTect SYBR Green Assays in human, mouse, rat PIK3R1
    QuantiFast Probe-based Assays in human, mouse, rat PIK3R1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3R1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PIK3R1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pik3r11 , 5 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) less1, 5 88.26(n)1
    95.99(a)1
      13 (53.92 cM)5
    187081  NM_001077495.21  NP_001070963.11 
     1016807615 
    chicken
    (Gallus gallus)
    Aves PIK3R11 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) less 83.15(n)
    89.09(a)
      427171  XM_424759.4  XP_424759.1 
    lizard
    (Anolis carolinensis)
    Reptilia PIK3R16
    phosphoinositide-3-kinase, regulatory subunit 1 (a...
    87(a)
    1 ↔ 1
    2(11914900-11972983)
    African clawed frog
    (Xenopus laevis)
    Amphibia AY062922.12   -- 74.15(n)    AY062922.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pik3r11 phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) less 72.15(n)
    79.28(a)
      557176  XM_678727.5  XP_683819.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pi3K21B6
    Pi3K21B
    28(a)
    1 → many
    2L(297880-305233)
    worm
    (Caenorhabditis elegans)
    Secernentea aap-11 aap-1 47.2(n)
    34.71(a)
      172141  NM_059121.7  NP_491522.1 


    ENSEMBL Gene Tree for PIK3R1 (if available)
    TreeFam Gene Tree for PIK3R1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PIK3R1 gene
    PIK3R22  PIK3R32  ENSG000002681732  
    6 SIMAP similar genes for PIK3R1 using alignment to 9 protein entries:     P85A_HUMAN (see all proteins):
    DKFZp686F1293    DKFZp686P05226    PIK3R3    PIK3R2    ARHGAP24    MYO9A

    Find genes that share paralogs with PIK3R1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PIK3R1 (see all 1867)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0702234
    SHORT syndrome (SHORTS)4--see VAR_0702232 R W mis40--------
    VAR_0702214
    SHORT syndrome (SHORTS)4--see VAR_0702212 E K mis40--------
    rs589523181,2
    C--64476257(+) CATCATCATC   
      ATCA
    /-
    CCCAA
    2 -- int1 cds11Minor allele frequency- -:0.50NA 2
    rs581889581,2
    C--64494483(+) TTTTT-/G/TGTTTT 1 -- int10--------
    rs1851801,2
    C,F--64497603(+) AGGACT/CGCCCC 1 -- int11Minor allele frequency- C:0.00NA 2
    rs1996966511,2
    --64497604(+) GACCG-/CCCCCC 1 -- int10--------
    rs113511051,2
    C--64499406(+) GTATA-/TTTTTT 1 -- int1 trp31Minor allele frequency- T:0.00NA 2
    rs2010976911,2
    --64499407(+) TATAT-/ATTTTT 1 -- int10--------
    rs737710331,2
    C--64507931(+) TTTTCC/TTTTTT 1 -- int11Minor allele frequency- T:0.50WA 2
    rs2514001,2
    H--64507941(-) ATCATA/TAAAAA 1 -- int1 trp34Minor allele frequency- T:0.00NS EA 414

    HapMap Linkage Disequilibrium report for PIK3R1 (67511548 - 67597649 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PIK3R1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1041177CNV Insertion17803354
    nsv462210CNV Loss19166990
    nsv517504CNV Loss19592680
    esv28511CNV Loss19812545
    nsv830331CNV Gain17160897

    Human Gene Mutation Database (HGMD): PIK3R1
    Selected Site Specific Mutation Identification with PCR Assays for PIK3R1 (see all 9):
    Cosmic IdAA Change
    85926p.R348*
    33546p.N453_T454insN
    87219p.R574_T576del
    87544p.R574T
    85888p.M582_D605>I
    3 Site Specific Cancer Mutation PCR Panels containing PIK3R1:
    PI3K-PTEN Pathway
    Cancer Comprehensive Panel 384HT
    Oncogene Panel 384HT
    SeqTarget long-range PCR primers for resequencing PIK3R1
    DNA2.0 Custom Variant and Variant Library Synthesis for PIK3R1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 171833   
    OMIM disorders: 615214  269880  
    UniProtKB/Swiss-Prot: P85A_HUMAN, P27986
  • Agammaglobulinemia 7, autosomal recessive (AGM7) [MIM:615214]: A primary immunodeficiency characterized
    by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of
    B-cell development. Affected individuals develop severe infections in the first years of life. Note=The disease
    is caused by mutations affecting the gene represented in this entry
  • SHORT syndrome (SHORTS) [MIM:269880]: A rare, multisystem disease characterized by short stature,
    anomalies of the anterior chamber of the eye, characteristic facial features such as triangular facies, lack of
    facial fat, and hypoplastic nasal alae with overhanging columella, partial lipodystrophy, hernias,
    hyperextensibility, and delayed dentition. The clinical phenotype can include insulin resistance,
    nephrocalcinosis, and hearing deficits. Developmental milestones and cognition are normal. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • 8 diseases for PIK3R1:    
    About MalaCards
    short syndrome    agammaglobulinemia 7, autosomal recessive    diaphragmatic hernia 3    leopard syndrome
    agammaglobulinemia    agammaglobulinemia 3    hypersplenism    insulin resistance


    Find genes that share disorders with PIK3R1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PIK3R1 gene (see all 46)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin resistance 53.9 29 16166093 (5), 16873706 (3), 18948408 (3), 16491394 (2) (see all 12)
    cancer 45.5 50 19279572 (3), 19368348 (2), 20421047 (2), 15641016 (1) (see all 36)
    breast cancer 40.5 38 19133120 (4), 15580312 (3), 16246546 (2), 16168140 (2) (see all 20)
    insulin sensitivity 40.3 13 16491394 (2), 16166093 (2), 9032108 (1), 11270682 (1) (see all 7)
    tumors 38.8 57 15678684 (4), 19509421 (3), 19685150 (3), 19095950 (2) (see all 39)
    prostate cancer 29 9 18372911 (2), 16015604 (1), 18476967 (1), 20019190 (1) (see all 8)
    leukemogenesis 27.8 2 11560856 (1)
    tuberous sclerosis 22.3 2 15249583 (1), 15653324 (1)
    niddm 21 4 15910625 (2), 9032108 (1), 12397383 (1)
    wiskott-aldrich syndrome 18.1 2 8824280 (1), 11865026 (1)

    Genetic Association Database (GAD): PIK3R1
    Human Genome Epidemiology (HuGE) Navigator: PIK3R1 (28 documents)
    Tumor Gene Database (TGDB): PIK3R1

    Export disorders for PIK3R1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for PIK3R1 gene, integrated from 10 sources (see all 1229):
    (articles sorted by number of sources associating them with PIK3R1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain. (PubMed id 8628286)1, 2, 9 Antonetti D.A.... Kahn C.R. (Mol. Cell. Biol. 1996)
    2. Association between phosphatidylinositol 3-kinase regulatory subunit p85alpha Met326Ile genetic polymorphism and colon cancer risk. (PubMed id 18245521)1, 4, 9 Li L....Casey G. (Clin. Cancer Res. 2008)
    3. Association analysis of the variant in the regulatory subunit of phosphoinositide 3-kinase (p85alpha) with Type 2 diabetes mellitus and hypertension in the Chinese Han population. (PubMed id 15910625)1, 4, 9 Chen S....Gu D. (Diabet. Med. 2005)
    4. Identification of a common amino acid polymorphism in the p85alpha regulatory subunit of phosphatidylinositol 3-kinase: effects on glucose disappearance constant, glucose effectiveness, and the insulin sensitivity index. (PubMed id 9032108)1, 2, 9 Hansen T.... Pedersen O. (Diabetes 1997)
    5. Common polymorphisms in the genes regulating the early insulin signalling pathway: effects on weight change and the conversion from impaired glucose tolerance to Type 2 diabetes. The Finnish Diabetes Prevention Study. (PubMed id 15127203)1, 4, 9 Laukkanen O....Laakso M. (Diabetologia 2004)
    6. Large-scale investigation of genomic markers for severe periodontitis. (PubMed id 15490304)1, 4, 9 Suzuki A....Kamoi K. (Odontology 2004)
    7. Genetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease. (PubMed id 12185156)1, 4, 9 Liolitsa D....Lovestone S. (J. Neurol. Neurosurg. Psychiatr. 2002)
    8. Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase. (PubMed id 12186904)1, 2, 9 He Y.... Katze M.G. (J. Virol. 2002)
    9. Structure of the PI3K SH3 domain and analysis of the SH3 family. (PubMed id 7681364)1, 2, 9 Koyama S....Schreiber S.L. (Cell 1993)
    10. Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta. (PubMed id 1314371)1, 3, 9 Volinia S.... Waterfield M.D. (Oncogene 1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5295 HGNC: 8979 AceView: PIK3R1 Ensembl:ENSG00000145675 euGenes: HUgn5295
    ECgene: PIK3R1 Kegg: 5295 H-InvDB: PIK3R1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PIK3R1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PIK3R1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PIK3R1 gene:
    Search GeneIP for patents involving PIK3R1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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