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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PIK3R1 Gene

protein-coding GIFtS: 72
GCID: GC05P067511

phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

Explore 84 diseases affiliated with
PIK3R1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phosphoinositide-3-Kinase, Regulatory Subunit 1 (Alpha)¹ ²		PI3K Regulatory Subunit Alpha² ³
GRB1¹ ² ³ ⁵		Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha²
P85¹		Phosphatidylinositol 3-Kinase, Regulatory Subunit, Polypeptide 1 (P85 Alpha)²
P85-ALPHA¹		Phosphatidylinositol 3-Kinase-Associated P-85 Alpha²
Phosphatidylinositol 3-Kinase 85 KDa Regulatory Subunit Alpha² ³		Phosphoinositide-3-Kinase Regulatory Subunit²
PtdIns-3-Kinase Regulatory Subunit Alpha² ³		PI3-Kinase Regulatory Subunit Alpha³
PI3-Kinase Subunit P85-Alpha² ³		PtdIns-3-Kinase Regulatory Subunit P85-Alpha³

External Ids:	HGNC: 8979¹	Entrez Gene: 5295²	Ensembl: ENSG00000145675⁷	OMIM: 171833⁵	UniProtKB: P27986³

Export aliases for PIK3R1 gene to outside databases

Previous GC identifers: GC05P067677 GC05P069074 GC05P067492 GC05P067538 GC05P067558 GC05P064479

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PIK3R1:

Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The

enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the

85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin,

and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in

four transcript variants encoding different isoforms. (provided by RefSeq, Jun 2011)

UniProtKB/Swiss-Prot: P85A_HUMAN, P27986

Function: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter,

mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated

increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling

in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2

signaling

summary for PIK3R1:

PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the

3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of

cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell

migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric

consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and

delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst

p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have

recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes

(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI

3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to

play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3R1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006713.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PIK3R1 gene promoter:
AP-1 CUTL1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): PIK3R1 promoter sequence

Search SABiosciences Chromatin IP Primers for PIK3R1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIK3R1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.1 Ensembl cytogenetic band: 5q13.1 HGNC cytogenetic band: 5q13.1

PIK3R1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIK3R1 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P067511: view genomic region (about GC identifiers)

Start:	67,511,548 bp from pter	End:	67,597,649 bp from pter
Size:	86,102 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: P85A_HUMAN, P27986 (See protein sequence)

Recommended Name: Phosphatidylinositol 3-kinase regulatory subunit alpha

Size: 724 amino acids; 83598 Da

Subunit: Heterodimer of a regulatory subunit PIK3R1 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts

with FER. Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated). Interacts with PTK2/FAK1 (By

similarity). Interacts with phosphorylated TOM1L1. Interacts with phosphorylated LIME1 upon TCR and/or BCR activation.

Interacts with SOCS7. Interacts with RUFY3. Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated). Interacts

with LYN (via SH3 domain); this enhances enzyme activity (By similarity). Interacts with phosphorylated LAT, LAX1 and

TRAT1 upon TCR activation. Interacts with CBLB. Interacts with HIV-1 Nef to activate the Nef associated p21-activated

kinase (PAK). This interaction depends on the C-terminus of both proteins and leads to increased production of HIV.

Interacts with HCV NS5A. The SH2 domains interact with the YTHM motif of phosphorylated INSR in vitro. Also interacts

with tyrosine-phosphorylated IGF1R in vitro. Interacts with CD28 and CD3Z upon T-cell activation. Interacts with IRS1

and phosphorylated IRS4, as well as with NISCH and HCST. Interacts with FASLG, KIT and BCR. Interacts with AXL, FGFR1,

FGFR2, FGFR3 and FGFR4 (phosphorylated). Interacts with FGR and HCK. Interacts with PDGFRA (tyrosine phosphorylated)

and PDGFRB (tyrosine phosphorylated). Interacts with ERBB4 (phosphorylated). Interacts with NTRK1 (phosphorylated upon

ligand-binding)

6/18 PDB 3D structures from and Proteopedia for PIK3R1 (see all 18):

1A0N (3D)

1AZG (3D)

1H9O (3D)

1PBW (3D)

1PHT (3D)

1PIC (3D)

Secondary accessions: B3KT19 D3DWA0 E7EX19 Q15747 Q4VBZ7 Q53EM6 Q8IXA2 Q8N1C5

Alternative splicing: 5 isoforms: P27986-1 P27986-2 P27986-3 P27986-4 P27986-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PIK3R1: NX_P27986

Post-translational modifications:

Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28

and CD3Z upon T-cell activation¹

Phosphorylated. Tyrosine phosphorylated in response to signaling by FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylated by

CSF1R. Phosphorylated by ERBB4. Phosphorylated on tyrosine residues by TEK/TIE2. Dephosphorylated by PTPRJ.

Phosphorylated by PIK3CA at Ser-608; phosphorylation is stimulated by insulin and PDGF. The relevance of

phosphorylation by PIK3CA is however unclear (By similarity). Phosphorylated in response to KIT and KITLG/SCF.

Phosphorylated by FGR¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P27986

PIK3R1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001229395.1 NP_852556.2 NP_852664.1 NP_852665.1

ENSEMBL proteins:

ENSP00000428056 ENSP00000429277 ENSP00000428566 ENSP00000430126 ENSP00000429766

ENSP00000323512 ENSP00000431058 ENSP00000338554 ENSP00000430424 ENSP00000429156

ENSP00000430098 ENSP00000379855 ENSP00000274335

Reactome Protein details: P27986
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant PIK3R1 Protein
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: PIK3R1 OriGene Protein Over-expression Lysate (see all 2): PIK3R1 OriGene Custom Protein Services for PIK3R1
	GenScript Custom Purified and Recombinant Proteins Services for PIK3R1
	Novus Biologicals PIK3R1 Proteins Novus Biologicals PIK3R1 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for PIK3R1
	Uscn Proteins for PIK3R1

Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005625	soluble fraction	--	--
GO:0005634	nucleus	--	--
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	TAS	--

PIK3R1 for ontologies About GeneDecksing

PIK3R1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PIK3R1
	R&D Systems Antibodies for PIK3R1 (PI 3-Kinase p85 alpha)
	Cell Signaling Technology (CST) Antibodies for PIK3R1
	OriGene Antibodies (see all 6): PIK3R1 OriGene Custom Antibody Services for PIK3R1
	GenScript Superior Antibodies for PIK3R1
	Novus Biologicals PIK3R1 Antibodies
	Abcam antibodies for PIK3R1
	Uscn Antibodies for PIK3R1
	ThermoFisher Antibodies for PIK3R1

Assay Products for PIK3R1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PIK3R1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PIK3R1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PIK3R1 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR008936 Rho_GTPase_activation_prot

IPR001720 PI3kinase_P85

IPR001452 SH3_domain

IPR011511 SH3_2

IPR000980 SH2

Graphical View of Domain Structure for InterPro Entry P27986

ProtoNet protein and cluster: P27986

3 Blocks protein families:

IPB000198 RhoGAP domain

IPB000980 SH2 domain signature

IPB001720 PI3 kinase P85 regulatory subunit signature

UniProtKB/Swiss-Prot: P85A_HUMAN, P27986

Domain: The SH3 domain mediates the binding to CBLB, and to HIV-1 Nef

Similarity: Belongs to the PI3K p85 subunit family

Similarity: Contains 1 Rho-GAP domain

Similarity: Contains 2 SH2 domains

Similarity: Contains 1 SH3 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: P85A_HUMAN, P27986

Function: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter,

mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated

increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling

in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2

signaling

Genatlas biochemistry entry for PIK3R1:

phosphatidylinositol 3-kinase (p85 alpha),regulatory subunit,class IA adaptor molecule associating 110-120kDa catalytic

subunits,interacting with tyrosine kinase (signal transduction),interacting with inositol polyphosphatase

4-phosphatase and inositol polyphosphatase 5-phosphatase forming complex with SHIP (INPP5D) and SHP2

(PTPN11),expressed in B and T cells,also interacting with IRS1 and playing a potential role in glucose homeostasis

miRNA Products:		miRTarBase miRNAs that target PIK3R1: hsa-mir-29a (MIRT004103)

		OriGene 3'-UTR Clone (see all 3): PIK3R1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIK3R1
		8/114 QIAGEN miScript miRNA Assays for microRNAs that regulate PIK3R1 (see all 114):
		hsa-miR-607 hsa-miR-642a hsa-miR-361-5p hsa-miR-3607-3p hsa-miR-376b hsa-miR-15a hsa-miR-199a-3p hsa-miR-106a

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PIK3R1 (see all 7) OriGene shRNA RFP: PIK3R1 OriGene siRNA: PIK3R1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIK3R1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PIK3R1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3R1 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3R1 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): PIK3R1 (NM_181523)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIK3R1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3R1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PIK3R1
		Search LifeMap BioReagents cell lines for PIK3R1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3R1

Gene Ontology (GO): 5/24 molecular function terms (GO ID links to tree view) (see all 24): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	ISS	--
GO:0005102	receptor binding	--	--
GO:0005158	insulin receptor binding	IPI	8276809
GO:0005159	insulin-like growth factor receptor binding	IPI	7541045
GO:0005168	neurotrophin TRKA receptor binding	IPI	15488758

PIK3R1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for PIK3R1:

Increased cell death in breast

Increased homologous recombina

Animal Models:
Mouse knock-outs for PIK3R1: Pik3r1^tm2Dfr Pik3r1^tm1Tka Pik3r1^tm1Dfr Pik3r1^tm1Khn
13 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Pik3r1):

adipose tissue	cardiovascular system	cellular	growth/size	hematopoietic system
homeostasis/metabolism	immune system	liver/biliary system	mortality/aging	muscle
no phenotypic analysis	normal	tumorigenesis

PIK3R1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/214 super-pathways (see all 214) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development_CNTF receptor signaling

8/21 pathways (see all 21)
Development_CNTF receptor signaling	1.00	Development Growth hormone signaling via PI3K/AKT and MAPK cascades	0.34
Development CNTF receptor signaling	1.00	Translation _Regulation of EIF4F activity	0.32
Transcription Receptor-mediated HIF regulation	0.43	Translation Regulation activity of EIF4F	0.32
Transcription_Receptor-mediated HIF regulation	0.43	ErbB2/ErbB3 signaling events	0.31

Development HGF signaling pathway

8/20 pathways (see all 20)
Development HGF signaling pathway	1.00	Apoptosis and survival_NGF signaling pathway	0.25
Development_HGF signaling pathway	0.78	Apoptosis and survival NGF signaling pathway	0.25
Development_Neurotrophin family signaling	0.45	Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR1	0.24
Development Neurotrophin family signaling	0.45	Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1	0.24

IL-9 Signaling Pathways

8/15 pathways (see all 15)
IL-9 Signaling Pathways	1.00	Immune response_IL-9 signaling pathway	0.42
IL-21 Signaling Pathways	0.90	Immune response IL-9 signaling pathway	0.42
IL-7 Signaling Pathways	0.90	IL-7 Signaling Pathway	0.38
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways	0.90	Development_Thrombopoietin-regulated cell processes	0.36

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

Development_PDGF signaling via STATs and NF-kB

8/11 pathways (see all 11)
Development_PDGF signaling via STATs and NF-kB	1.00	Immune response_IL-10 signaling pathway	0.28
Development PDGF signaling via STATs and NF-kB	1.00	Immune response IL-10 signaling pathway	0.28
Immune response_IL-23 signaling pathway	0.44	IL23-mediated signaling events	0.15
Immune response IL-23 signaling pathway	0.41	Angiopoietin-TIE2 Signaling	0.13

Pathway sources
See GeneCards unified pathways
Show all pathways

5/66 EMD Millipore Pathways for PIK3R1 (see all 66)

	Translation Translation regulation by Alpha-1 adrenergic receptors
	Development Activation of ERK by Alpha-1 adrenergic receptors
	Immune response CD16 signaling in NK cells
	Cytoskeleton remodeling FAK signaling
	Cytoskeleton remodeling Role of PDGFs in cell migration

5/9 R&D Systems Pathways for PIK3R1 (see all 9)

	IL-21 Signaling Pathways
	IL-2 Signaling Pathways
	IL-4 Signaling Pathways
	Adipocytokines & Insulin Signaling
	IL-7 Signaling Pathways

5/131 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PIK3R1 (see all 131)

	Fc-GammaR Pathway
	Toll-Like Receptors Pathway
	Molecular Mechanisms of Cancer
	eIF2 Pathway
	JNK Pathway

1 Cell Signaling Technology (CST) Pathway for PIK3R1

PI3K / Akt Signaling

5/9 Tocris Bioscience Pathways for PIK3R1 (see all 9)

	Akt Pathway
	Insulin Pathway
	Apoptosis Pathway
	NF-kappaB Pathway
	Toll-like Receptor Pathway

5/67 GeneGo (Thomson Reuters) Pathways for PIK3R1 (see all 67)

	Development CNTF receptor signaling
	Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
	Development EGFR signaling pathway
	Signal transduction AKT signaling
	Immune response IL-9 signaling pathway

5/90 BioSystems Pathways for PIK3R1 (see all 90)

	Signaling Pathways in Glioblastoma
	Focal Adhesion
	AMPK signaling
	Apoptosis
	EGFR1 Signaling Pathway

5/78 Reactome Pathways for PIK3R1 (see all 78)

	Nephrin interactions
	IRS-mediated signalling
	Signaling by PDGF
	Downstream Signaling Events Of B Cell Receptor (BCR)
	Signalling by NGF

3 PharmGKB Pathways for PIK3R1

	Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
	EGFR Inhibitor Pathway, Pharmacodynamics
	Sorafenib Pharmacodynamics

5/43 Kegg Pathways (Kegg details for PIK3R1) (see all 43):

	ErbB signaling pathway
	Chemokine signaling pathway
	Phosphatidylinositol signaling system
	mTOR signaling pathway
	Apoptosis

PIK3R1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PIK3R1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/644 Interacting proteins for PIK3R1 (P27986^{1, 2, 3} ENSP00000274335⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 644)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ERBB3	P21860¹^,²^,³, ENSP00000267101⁴	EBI-79464,EBI-720706 MINT-74605 MINT-74600 MINT-74616 MINT-74613 MINT-74601 MINT-74612 MINT-74615 MINT-74597 MINT-74602 MINT-74596 MINT-74614 MINT-74611 MINT-74604 MINT-74617 MINT-74603 I2D: score=7 STRING: ENSP00000267101
PDGFRB	P09619²^,³, ENSP00000261799⁴	MINT-8029783 MINT-8029948 MINT-8029933 MINT-8029858 MINT-8030936 MINT-8031128 MINT-8029888 MINT-8031173 MINT-8029798 MINT-8030966 MINT-8030997 MINT-8031204 MINT-8029963 MINT-8030981 MINT-8031012 MINT-8031113 MINT-8031053 MINT-8031143 I2D: score=6 STRING: ENSP00000261799
CBL	P22681²^,³, ENSP00000264033⁴	MINT-50733 MINT-68500 MINT-14996 MINT-7103607 MINT-65975 MINT-7214865 MINT-50723 MINT-68494 MINT-65977 MINT-8036115 MINT-8036175 MINT-8028565 MINT-15294 MINT-7103683 MINT-8029727 I2D: score=5 STRING: ENSP00000264033
IRS1	P35568²^,³, ENSP00000304895⁴	MINT-8036617 MINT-8028908 MINT-8036602 MINT-8033089 MINT-8036587 MINT-8033340 MINT-8036572 MINT-8028923 MINT-8033074 MINT-68735 I2D: score=10 STRING: ENSP00000304895
CD28	P10747²^,³, ENSP00000324890⁴	MINT-8036648 MINT-8036674 MINT-8036765 MINT-8036633 MINT-8036690 MINT-8036705 MINT-8036750 MINT-8036780 I2D: score=4 STRING: ENSP00000324890

About this table

Gene Ontology (GO): 5/63 biological process terms (GO ID links to tree view) (see all 63): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001878	response to yeast	--	--
GO:0001934	positive regulation of protein phosphorylation	--	--
GO:0001953	negative regulation of cell-matrix adhesion	IEA	--
GO:0006006	glucose metabolic process	--	--
GO:0006468	protein phosphorylation	IEA	--

PIK3R1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PIK3R1 for compounds About GeneDecksing

EMD Millipore small molecules for PIK3R1:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for PIK3R1 available from Tocris Bioscience About this table

Compound	Action	CAS #
LY 294002 hydrochloride	Selective PI 3-kinase inhibitor	[154447-36-6]
Quercetin	Non-selective PI 3-kinase inhibitor	[117-39-5]
PI 103 hydrochloride	Inhibitor of PI 3-kinase, mTOR and DNA-PK	[371935-74-9]
BAG 956	Dual PI 3-kinase and PDK1 inhibitor	[853910-02-8]
PI 828	PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130)	[942289-87-4]

2 DrugBank Compounds for PIK3R1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Isoproterenol	Epinephrine Isopropyl Homolog (see all 14)	7683-59-2	target	agonist	15985706 15527548 15381832 15618457 15110780
(1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE	--	--	target	--	10592235

10/69 Novoseek chemical compound relationships for PIK3R1 gene (see all 69) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphatidylinositol	91.9	368	9054447 (6), 7961856 (4), 1372092 (3), 14683460 (3) (see all 99)
phosphoinositide	86.5	173	11027274 (5), 14504291 (3), 18516572 (3), 19207420 (3) (see all 99)
tyrosine	78.3	170	7678051 (3), 7509794 (3), 10358153 (3), 8816504 (3) (see all 99)
rapamycin	70.1	38	17908691 (3), 15641016 (1), 15653324 (1), 16916489 (1) (see all 27)
phosphotyrosine	69.1	18	15700969 (2), 1375321 (1), 8952511 (1), 9583121 (1) (see all 14)
glycogen	68.1	32	11334418 (1), 15691882 (1), 16055672 (1), 10330191 (1) (see all 28)
phosphatidylinositol-3,4,5-trisphosphate	65.6	11	11805146 (1), 17335807 (1), 12933652 (1), 15986137 (1) (see all 8)
pp36	62.6	4	7544353 (2), 9541596 (1)
threonine	55.1	15	17625596 (2), 15795286 (1), 18786649 (1), 11368419 (1) (see all 13)
serine	54.7	28	11313980 (4), 8388374 (2), 16873706 (2), 18948408 (2) (see all 18)

Search CenterWatch for drugs/clinical trials and news about PIK3R1 / P85A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PIK3R1 gene (4 alternative transcripts):

NM_001242466.1 NM_181504.3 NM_181523.2 NM_181524.1

Unigene Cluster for PIK3R1:

Phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

Hs.132225 [show with all ESTs]

Unigene Representative Sequence: NM_181523

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000521381(uc003jva.3 uc003jvc.3 uc003jvd.3 uc003jve.3 uc021xzn.1)

ENST00000521657 ENST00000517643 ENST00000517412 ENST00000520675 ENST00000523807

ENST00000522084 ENST00000320694 ENST00000521409 ENST00000336483 ENST00000518292

ENST00000517698 ENST00000518813 ENST00000519025 ENST00000523872 ENST00000520550(uc011crb.2)

ENST00000396611 ENST00000274335

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		hsa-miR-607 hsa-miR-642a hsa-miR-361-5p hsa-miR-3607-3p hsa-miR-376b hsa-miR-15a hsa-miR-199a-3p hsa-miR-106a

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Additional cDNA sequence:

AF279367.1 AK000121.1 AK094785.1 AK126345.1 AK223613.1 AK294919.1 AK299743.1 BC030815.1

BC094795.1 JX133164.1 JX133165.1 L26969.1 L30106.1 M61906.1 U49349.1

17 DOTS entries:

DT.85100648 DT.100798319 DT.99928781 DT.120820335 DT.95160311 DT.92425727 DT.120820321 DT.92425719

DT.100798321 DT.92425724 DT.95268235 DT.75176710 DT.95207719 DT.120820311 DT.120820329 DT.95268236

DT.91688907

24/295 AceView cDNA sequences (see all 295):

BM980356 F09178 BF108547 CF528903 AI190793 NM_181523 AI468333 BI769018

F11517 AI124626 AA463460 F11518 NM_181524 CF994983 Z41711 AA653383

Z44767 BU631300 BQ631779 AA010802 AV709741 AW016460 AW444493 AA354917

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for PIK3R1 (see all 9) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	^	10	^	11	^	12	^	13a	·	13b	^	14a	·	14b	^	15a	·	15b	·	15c	^	16	^	17	^	18	^	19a	·
SP1:													-		-		-		-		-				-		-
SP2:																	-		-		-				-		-
SP3:																					-				-		-
SP4:																									-		-
SP5:

ExUns:	19b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for PIK3R1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PIK3R1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGATAGCATT

About this image

PIK3R1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lateral Plate Mesoderm

Embryonic Blood Islands

Angioblasts

Endothelium

Lateral Plate Mesoderm

Embryonic Capillary Plexus

Angioblasts

Endothelium

Heart

Atrioventricular Canal

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

See PIK3R1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PIK3R1

SOURCE GeneReport for Unigene cluster: Hs.132225

UniProtKB/Swiss-Prot: P85A_HUMAN, P27986

Tissue specificity: Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac

muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level)

SABiosciences Expression via Pathway-Focused PCR Arrays including PIK3R1 (see all 10):

mTOR Signaling in human mouse rat

Insulin Signaling Pathway in human mouse rat

VEGF Signaling in human mouse rat

T-cell & B-cell Activation in human mouse rat

Diabetes in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PIK3R1 gene from 7/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pik3r1^{1 , 5}	phosphatidylinositol 3-kinase, regulatory subunit, more^{1, 5}	88.26(n)¹ 95.99(a)¹		13 (53.92 cM)⁵ 18708¹ NM_001077495.1¹ NP_001070963.1¹ 101680761⁵
chicken (Gallus gallus)	Aves	PIK3R1¹	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	83.15(n) 89.09(a)		427171 XM_424759.3 XP_424759.1
lizard (Anolis carolinensis)	Reptilia	PIK3R1⁶	--	87(a)	1 ↔ 1	2(11914900-11968040)
African clawed frog (Xenopus laevis)	Amphibia	AY062922.1²	--	74.15(n)		AY062922.1
zebrafish (Danio rerio)	Actinopterygii	pik3r1¹	phosphoinositide-3-kinase, regulatory subunit 1 (p85 more	72.15(n) 79.28(a)		557176 XM_678727.4 XP_683819.3
fruit fly (Drosophila melanogaster)	Insecta	Pi3K21B⁶	Pi3K21B	27(a)	possible ortholog	2L(297880-305233)
worm (Caenorhabditis elegans)	Secernentea	aap-1¹	Protein AAP-1	46.7(n) 33.79(a)		172141 NM_059121.6 NP_491522.1

ENSEMBL Gene Tree for PIK3R1 (if available)
TreeFam Gene Tree for PIK3R1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PIK3R1 gene

PIK3R2² PIK3R3²

6 SIMAP similar genes for PIK3R1 using alignment to 9 protein entries: P85A_HUMAN (see all proteins):

DKFZp686F1293 DKFZp686P05226 PIK3R3 PIK3R2 ARHGAP24 MYO9A

PIK3R1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75454926^1,2	F,	--	64466950(+)	`CTGAAT/CTTATT`	1	--	us2k¹		1		WA	118
rs111299764^1,2		--	64467196(+)	`CACTGG/TTAGAG`	1	--	us2k¹		1		CSA	1
rs62357323^1,2	C,F,	--	64467308(+)	`TATCAT/CTCCAT`	1	--	us2k¹		3		NA	124
rs55960571^1,2	C,	--	64467706(+)	`GGAACT/GATAAA`	1	--	us2k¹		2		CSA NA	122
rs62357324^1,2	F,	--	64468164(+)	`GAGGCG/AGCGGT`	1	--	us2k¹		4		NA CSA WA	242
rs73126552^1,2	C,	--	64468379(+)	`TCTGCT/AGGGGC`	1	--	us2k¹		4		WA CSA NA	242
rs193995^1,2		--	64468665(-)	`TGGCAG/ATGGGG`	1	--	us2k¹		2		MN NA	186
rs251395^1,2	C,	--	64468693(-)	`GCACGG/CCTCGG`	1	--	us2k¹		2		MN NA	186
rs72770171^1,2	C,	--	64469659(+)	`AGCTTG/TGGCAG`	1	--	int¹		1		NA	120
rs77461521^1,2		--	64469781(+)	`GCCAGC/GGAGCC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PIK3R1 (67511548 - 67597649 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PIK3R1
1 Indel: 51730
Human Gene Mutation Database (HGMD): PIK3R1

5/9 SABiosciences Cancer Mutation PCR Assays for PIK3R1 (see all 9):

Cosmic Id	AA Change
85926	p.R348*
33546	p.N453_T454insN
87219	p.R574_T576del
87544	p.R574T
85888	p.M582_D605>I

3 SABiosciences Cancer Mutation PCR Arrays containing PIK3R1:

PI3K-PTEN Pathway

Cancer Comprehensive Panel 384HT

Oncogene Panel 384HT

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PIK3R1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PIK3R1 for disorders           About GeneDecksing

OMIM gene information: 171833    OMIM disorders: --

20/84 diseases for PIK3R1 (see all 84):    About MalaCards

insulin resistance wiskott-aldrich syndrome polycystic ovary syndrome nonalcoholic steatohepatitis

type 2 diabetes mellitus gastrointestinal stromal tumor ataxia telangiectasia tuberous sclerosis

muscle hypertrophy hypersplenism systemic mastocytosis mastocytosis

leopard syndrome myeloid leukemia diabetes mellitus morbid obesity

gestational diabetes hepatitis c chronic myeloid leukemia acute myeloid leukemia

10/46 Novoseek disease relationships for PIK3R1 gene (see all 46) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
insulin resistance	53.9	29	16166093 (5), 16873706 (3), 18948408 (3), 16491394 (2) (see all 12)
cancer	45.5	50	19279572 (3), 19368348 (2), 20421047 (2), 15641016 (1) (see all 36)
breast cancer	40.5	38	19133120 (4), 15580312 (3), 16246546 (2), 16168140 (2) (see all 20)
insulin sensitivity	40.3	13	16491394 (2), 16166093 (2), 9032108 (1), 11270682 (1) (see all 7)
tumors	38.8	57	15678684 (4), 19509421 (3), 19685150 (3), 19095950 (2) (see all 39)
prostate cancer	29	9	18372911 (2), 16015604 (1), 18476967 (1), 20019190 (1) (see all 8)
leukemogenesis	27.8	2	11560856 (1)
tuberous sclerosis	22.3	2	15249583 (1), 15653324 (1)
niddm	21	4	15910625 (2), 9032108 (1), 12397383 (1)
wiskott-aldrich syndrome	18.1	2	8824280 (1), 11865026 (1)

Genetic Association Database (GAD): PIK3R1
Human Genome Epidemiology (HuGE) Navigator: PIK3R1 (28 documents)
Tumor Gene Database (TGDB): PIK3R1

Export disorders for PIK3R1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PIK3R1 gene, integrated from 9 sources (see all 1195):
(articles sorted by number of sources associating them with PIK3R1)

Utopia: connect your pdf to the dynamic
world of online information

Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain. (PubMed id 8628286)^{1, 2, 9} Antonetti D.A.... Kahn C.R. (1996)
Association analysis of the variant in the regulatory subunit of phosphoinositide 3-kinase (p85alpha) with Type 2 diabetes mellitus and hypertension in the Chinese Han population. (PubMed id 15910625)^{1, 4, 9} Chen S....Gu D. (2005)
Identification of a common amino acid polymorphism in the p85alpha regulatory subunit of phosphatidylinositol 3-kinase: effects on glucose disappearance constant, glucose effectiveness, and the insulin sensitivity index. (PubMed id 9032108)^{1, 2, 9} Hansen T.... Pedersen O. (1997)
Common polymorphisms in the genes regulating the early insulin signalling pathway: effects on weight change and the conversion from impaired glucose tolerance to Type 2 diabetes. The Finnish Diabetes Prevention Study. (PubMed id 15127203)^{1, 4, 9} Laukkanen O....Laakso M. (2004)
Large-scale investigation of genomic markers for severe periodontitis. (PubMed id 15490304)^{1, 4, 9} Suzuki A....Kamoi K. (2004)
Genetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease. (PubMed id 12185156)^{1, 4, 9} Liolitsa D....Lovestone S. (2002)
Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase. (PubMed id 12186904)^{1, 2, 9} He Y.... Katze M.G. (2002)
Structure of the PI3K SH3 domain and analysis of the SH3 family. (PubMed id 7681364)^{1, 2, 9} Koyama S....Schreiber S.L. (1993)
Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta. (PubMed id 1314371)^{1, 3, 9} Volinia S.... Waterfield M.D. (1992)
A novel interaction between fibroblast growth factor receptor 3 and the p85 subunit of phosphoinositide 3-kinase: activation-depende nt regulation of ERK by p85 in multiple myeloma cells. (PubMed id 19286672)^{1, 2} Salazar L....Thompson L.M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5295	HGNC: 8979	AceView: PIK3R1	Ensembl:ENSG00000145675	euGenes: HUgn5295
ECgene: PIK3R1	Kegg: 5295	H-InvDB: PIK3R1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PIK3R1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PIK3R1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PIK3R1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PIK3R1 gene:
Search GeneIP for patents involving PIK3R1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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Recombinant Protein for PIK3R1

PIK3R1 Proteins, Antibodies, CLIAs, and ELISAs

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3R1

	Browse SwitchGear 3'UTR luciferase reporter plasmids for PIK3R1
	SwitchGear Promoter luciferase reporter plasmids for PIK3R1

ThermoFisher Antibodies for PIK3R1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3R1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes PIK3R1 gene at Home site.

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PIK3R1 Gene

phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

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PIK3R1 Gene

phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

Aliasesfor PIK3R1 gene

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for PIK3R1 gene

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for PIK3R1 gene

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for PIK3R1 gene

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for PIK3R1 gene

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for PIK3R1 gene

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for PIK3R1 gene

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for PIK3R1 gene

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for PIK3R1 gene

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for PIK3R1 gene

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for PIK3R1 gene

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for PIK3R1 gene

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for PIK3R1 gene

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