Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PIK3CG Gene

protein-coding   GIFtS: 71
GCID: GC07P106505

Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic...

(Previous names: phosphoinositide-3-kinase, catalytic, gamma polypeptide)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic Subunit
Gamma1 2
     PIK32
PtdIns-3-Kinase Subunit Gamma2 3     Phosphatidylinositol 3 Kinase Gamma, P110 Gamma2
PtdIns-3-Kinase Subunit P110-Gamma2 3     Phosphatidylinositol 3-Kinase Catalytic 110-KD Gamma2
Serine/Threonine Protein Kinase PIK3CG2 3     Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma
Isoform2
PI3Kgamma2 3     Phosphatidylinositol-4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit
Gamma2
p110gamma2 3     Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma
Isoform2
p120-PI3K2 3     Phosphoinositide-3-Kinase Gamma Catalytic Subunit2
PI3-Kinase Subunit Gamma2 3     EC 2.7.11.13
EC 2.7.1.1533 8     PI3K-gamma3
Phosphoinositide-3-Kinase, Catalytic, Gamma Polypeptide1     Phosphatidylinositol 4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit
Gamma3
1-Phosphatidylinositol 3-Kinase2     Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide3
PI3CG2     EC 2.7.18
PI3K2     

External Ids:    HGNC: 89781   Entrez Gene: 52942   Ensembl: ENSG000001058517   OMIM: 6012325   UniProtKB: P487363   

Export aliases for PIK3CG gene to outside databases

Previous GC identifers: GC07P104989 GC07P106052 GC07P106066 GC07P106099 GC07P106292 GC07P100864


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PIK3CG Gene:
This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme
that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator
of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an
important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in
promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of
cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified
in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene.
(provided by RefSeq, Sep 2013)

GeneCards Summary for PIK3CG Gene: 
PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma) is a protein-coding gene. Diseases associated with PIK3CG include tuberous sclerosis complex, and myeloid leukemia, and among its related super-pathways are Glioma and Toll-like receptor signaling pathway. GO annotations related to this gene include ephrin receptor binding and protein serine/threonine kinase activity. An important paralog of this gene is PIK3C2B.

UniProtKB/Swiss-Prot: PK3CG_HUMAN, P48736
Function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol
4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by
recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades
involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor
activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte
chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization
and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin
formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with
PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation.
Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together
with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling.
Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil
chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates
alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid
kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet
aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility.
Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels.
Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to ADRBK1
and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and
protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role
in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through
simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma
complex is activated by RAPGEF3 and which is involved in angiogenesis

summary for PIK3CG Gene:
PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the
3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of
cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell
migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric
consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and
delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst
p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have
recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes
(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI
3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to
play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3CG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PIK3CG gene promoter:
         MEF-2A   CREB   MEF-2   deltaCREB   STAT3   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIK3CG promoter sequence
   Search SABiosciences Chromatin IP Primers for PIK3CG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIK3CG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.3   Ensembl cytogenetic band:  7q22.3   HGNC cytogenetic band: 7q22

PIK3CG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIK3CG gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P106505:  view genomic region     (about GC identifiers)

Start:
106,505,723 bp from pter      End:
106,547,592 bp from pter
Size:
41,870 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 105,867,019-105,908,676     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PK3CG_HUMAN, P48736 (See protein sequence)
Recommended Name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform  
Size: 1102 amino acids; 126454 Da
Subunit: Heterodimer of a catalytic subunit PIK3CG and a PIK3R5 or PIK3R6 regulatory subunit. Interacts with
ADRBK1 through the PIK helical domain. Interaction with ADRBK1 is required for targeting to agonist-occupied
receptor. Interacts with PDE3B (By similarity). Interacts with TPM2. Interacts with EPHA8; regulates
integrin-mediated cell adhesion to substrate. Interacts with HRAS1; the interaction is required for membrane
recruitment and beta-gamma G protein dimer-dependent activation of the PI3K gamma complex PIK3CG:PIK3R6 (By
similarity)
Subcellular location: Cytoplasm. Cell membrane
Miscellaneous: Candidate target in therapy for inflammatory diseases. Selective inhibitors and protein ablation
are anti-inflammatory in multiple disease models such as asthma, rheumatoid arthritis, allergy, systemic lupus
erythematosus, airway inflammation, lung injury and pancreatitis (PubMed:18278175)
6/68 PDB 3D structures from and Proteopedia for PIK3CG (see all 68):
1E8Y (3D)        1E8Z (3D)        1HE8 (3D)        2A4Z (3D)        2A5U (3D)        2CHW (3D)    
Secondary accessions: A4D0Q6 Q8IV23 Q9BZC8

Explore the universe of human proteins at neXtProt for PIK3CG: NX_P48736

Explore proteomics data for PIK3CG at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P48736

  • 4/10 DME Specific Peptides for PIK3CG (P48736) (see all 10)
     IGHFLFW  NVRAIAV  SCAGYCV  IVAKTYQ 

    PIK3CG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PIK3CG Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001269355.1  NP_001269356.1  NP_002640.2  

    ENSEMBL proteins: 
     ENSP00000392258   ENSP00000419260   ENSP00000417623   ENSP00000352121  
    Reactome Protein details: P48736
    Human Recombinant Protein Products for PIK3CG: 
    EMD Millipore Purified and/or Recombinant PIK3CG Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for PIK3CG
    OriGene Purified Protein for PIK3CG
    OriGene Protein Over-expression Lysate for PIK3CG
    OriGene MassSpec for PIK3CG 
    OriGene Custom Protein Services for PIK3CG
    GenScript Custom Purified and Recombinant Proteins Services for PIK3CG
    Novus Biologicals PIK3CG Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PIK3CG
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA12507995
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IBA--
    GO:0005942phosphatidylinositol 3-kinase complex ----
    GO:00059441-phosphatidylinositol-4-phosphate 3-kinase, class IB complex IDA12507995

    PIK3CG for ontologies           About GeneDecksing



    PIK3CG Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PIK3CG
    R&D Systems Antibodies for PIK3CG (PI 3-Kinase p110 gamma)
    Cell Signaling Technology (CST) Antibodies for PIK3CG 
    OriGene Antibodies for PIK3CG
    OriGene Custom Antibody Services for PIK3CG
    GenScript Custom Superior Antibodies Services for PIK3CG
    Novus Biologicals PIK3CG Antibodies
    Abcam antibodies for PIK3CG
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for PIK3CG
    LSBio Antibodies in human, mouse, rat for PIK3CG 

    Assay Products for PIK3CG: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PIK3CG
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PIK3CG
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 
    Phosphatidylinositol-4,5-bisphosphate 3-kinase family

    5/10 InterPro protein domains (see all 10):
     IPR001263 PInositide-3_kin_accessory_dom
     IPR003113 PI3K_adapt-bd_dom
     IPR002420 PI3K_C2_dom
     IPR011009 Kinase-like_dom
     IPR000403 PI3/4_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P48736

    ProtoNet protein and cluster: P48736

    2 Blocks protein domains:
    IPB000341 Phosphoinositide 3-kinase
    IPB000403 Phosphatidylinositol 3- and 4-kinase


    UniProtKB/Swiss-Prot: PK3CG_HUMAN, P48736
    Similarity: Belongs to the PI3/PI4-kinase family
    Similarity: Contains 1 C2 PI3K-type domain
    Similarity: Contains 1 PI3K-ABD domain
    Similarity: Contains 1 PI3K-RBD domain
    Similarity: Contains 1 PI3K/PI4K domain
    Similarity: Contains 1 PIK helical domain


    PIK3CG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PK3CG_HUMAN, P48736
    Function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol
    4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by
    recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades
    involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor
    activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte
    chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization
    and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin
    formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with
    PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation.
    Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together
    with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling.
    Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil
    chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates
    alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid
    kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet
    aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility.
    Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels.
    Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to ADRBK1
    and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and
    protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role
    in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through
    simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma
    complex is activated by RAPGEF3 and which is involved in angiogenesis
    Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol
    3,4,5-trisphosphate
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by both the alpha and the beta-gamma G proteins following stimulation of G
    protein-coupled receptors (GPCRs). Activation by GPCRs is assisted by the regulatory subunits (PIK3R5 or PIK3R6)
    leading to the translocation from the cytosol to the plasma membrane and to kinase activation. Inhibited by
    AS-604850 and AS-605240

         Enzyme Numbers (IUBMB): EC 2.7.1.1531 2 EC 2.7.11.11 EC 2.7.12

         Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS19376709
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI12507995
    GO:0005524ATP binding IEA--
         
    PIK3CG for ontologies           About GeneDecksing


    Phenotypes:
         11 GenomeRNAi human phenotypes for PIK3CG:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella-containin  Decreased cilium length  Decreased cilium length after   Decreased focal adhesion (FA)  
     Decreased number of cells in m  Increased cell death HMECs cel  Increased cell death in breast 

         11 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Pik3cg):
     cardiovascular system  cellular  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  mortality/aging  muscle  skeleton 
     vision/eye 

    PIK3CG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pik3cgtm1Pngr for PIK3CG

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PIK3CG 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PIK3CG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PIK3CG 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PIK3CG 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIK3CG
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate PIK3CG (see all 10):
    hsa-miR-142-3p hsa-miR-502-5p hsa-miR-634 hsa-miR-922 hsa-miR-3166 hsa-miR-4255 hsa-miR-519e* hsa-miR-515-5p
    SwitchGear 3'UTR luciferase reporter plasmidPIK3CG 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PIK3CG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIK3CG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PIK3CG
    Sirion Biotech Customized adenovirus for overexpression of PIK3CG

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PIK3CG (see all 9)
    OriGene ORF clones in mouse, rat for PIK3CG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PIK3CG (NM_002649)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIK3CG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3CG
    Sirion Biotech Customized lentivirus for stable overexpression of PIK3CG 
                         Customized lentivirus expression plasmids for stable overexpression of PIK3CG 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PIK3CG
    Search LifeMap BioReagents cell lines for PIK3CG
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3CG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PIK3CG About   (see all 79)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glioma
    Glioma0.51
    Prostate cancer0.39
    Non-small cell lung cancer0.51
    Signaling Pathways in Glioblastoma0.36
    Melanoma0.43
    2Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Chagas disease (American trypanosomiasis)0.33
    Toll-like receptor signaling pathway0.93
    Hepatitis B0.31
    3PI Metabolism
    PI Metabolism0.66
    3-phosphoinositide biosynthesis0.48
    Synthesis of PIPs at the plasma membrane0.66
    4Inositol phosphate metabolism
    Inositol phosphate metabolism0.61
    superpathway of inositol phosphate compounds0.60
    Phosphatidylinositol signaling system0.61
    5Focal Adhesion
    Focal Adhesion0.64
    Focal adhesion0.64

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/12 EMD Millipore Pathways for PIK3CG (see all 12)
        Development EDNRB signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Development A1 receptor signaling
    Development A3 receptor signaling
    Immune response CCR3 signaling in eosinophils

    5/12 R&D Systems Pathways for PIK3CG (see all 12)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    Akt Signaling Pathway

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PIK3CG
        CCR3 Pathway in Eosinophils
    Molecular Mechanisms of Cancer
    Ephrin-Eph Signaling
    Akt Signaling
    EphrinA-EphR Signaling

    1 Cell Signaling Technology (CST) Pathway for PIK3CG
        PI3K / Akt Signaling

    5/9 Tocris Bioscience Pathways for PIK3CG (see all 9)
        Akt Pathway
    Insulin Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    Toll-like Receptor Pathway

    5/15 GeneGo (Thomson Reuters) Pathways for PIK3CG (see all 15)
        Development EPO-induced MAPK pathway
    Cell adhesion Integrin inside-out signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Development ACM2 and ACM4 activation of ERK
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions

    5/16 BioSystems Pathways for PIK3CG (see all 16)
        MicroRNAs in cardiomyocyte hypertrophy
    Focal Adhesion
    EGFR1 Signaling Pathway
    Insulin Signaling
    AMPK signaling

    5/13        Reactome Pathways for PIK3CG (see all 13)
        GPCR downstream signaling
    Hemostasis
    Metabolism
    Signaling by GPCR
    Phospholipid metabolism

    3 PharmGKB Pathways for PIK3CG
        Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Sorafenib Pharmacodynamics

    5/55         Kegg Pathways  (Kegg details for PIK3CG) (see all 55):
        Inositol phosphate metabolism
    ErbB signaling pathway
    Chemokine signaling pathway
    HIF-1 signaling pathway
    Phosphatidylinositol signaling system

    UniProtKB/Swiss-Prot: PK3CG_HUMAN, P48736
    Pathway: Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis


    PIK3CG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIK3CG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/370 Interacting proteins for PIK3CG (P487361, 2, 3 ENSP000003521214) via UniProtKB, MINT, STRING, and/or I2D (see all 370)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 5/36 biological process terms (GO ID links to tree view) (see all 36):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001816cytokine production TAS19075988
    GO:0002250adaptive immune response TAS17290298
    GO:0002407dendritic cell chemotaxis TAS18278175
    GO:0002675positive regulation of acute inflammatory response IEA--

    PIK3CG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PIK3CG for compounds           About GeneDecksing

    EMD Millipore small molecules for PIK3CG:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for PIK3CG

    Compounds for PIK3CG available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CZC 24832Selective inhibitor of PI 3-Kinase gamma[1159824-67-5]
    QuercetinNon-selective PI 3-kinase inhibitor[117-39-5]
    PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK [371935-74-9]
    AS 605240Potent and selective PI 3-kinase gamma (PI3Kgamma) inhibitor[648450-29-7]
    740 Y-PCell-permeable PI 3-kinase activator[1236188-16-1]

    10/382 HMDB Compounds for PIK3CG (see all 382)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Phosphatidyl-D-myo-inositol1-Phosphatidyl-1D-myo-inositol (see all 6)----
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    PI(16:0/16:0)Phosphatidylinositol(32:0) (see all 8)----
    PI(16:0/16:1(9Z))Phosphatidylinositol(32:1) (see all 14)----
    PI(16:0/16:2(9Z,12Z))Phosphatidylinositol(16:0/16:2n4) (see all 18)----
    PI(16:0/18:0)Phosphatidylinositol(16:0/18:0) (see all 8)----
    PI(16:0/18:1(11Z))Phosphatidylinositol(16:0/18:1w7) (see all 14)----
    PI(16:0/18:1(9Z))Phosphatidylinositol(16:0/18:1) (see all 14)----
    PI(16:0/18:2(9Z,12Z))PIno(16:0/18:2) (see all 14)----

    10/12 DrugBank Compounds for PIK3CG (see all 12)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Myricetin3,3',4,4',5',7-Hexahydro-2-phenyl-4H-chromen-4-one (see all 8)529-44-2target--17139284 17016423 10592235
    Staurosporine-- 62996-74-1target--17139284 17016423
    (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE-- --target--10592235
    (5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONE-- --target--10592235
    1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine-- --target--10592235
    2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE-- --target--10592235
    2-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-One-- 154447-36-6target--10592235
    3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL-- --target--10592235
    5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-one-- --target--10592235
    5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE-- --target--10592235

    10/126 Novoseek inferred chemical compound relationships for PIK3CG gene (see all 126)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ly294002 98.3 1722 12788194 (4), 16397049 (4), 15752900 (3), 17302559 (3) (see all 99)
    wortmannin 96.5 1002 7875216 (6), 9182708 (6), 8010944 (5), 9489996 (4) (see all 99)
    phosphatidylinositol 96.3 1503 8106507 (9), 1325371 (6), 1323287 (6), 8999962 (6) (see all 99)
    phosphoinositide 92.4 529 18388257 (2), 20163786 (2), 15231713 (2), 18081863 (2) (see all 99)
    pd 98,059 90.4 228 14635227 (2), 12657249 (2), 20517899 (2), 10433244 (2) (see all 99)
    rapamycin 83.4 224 18660503 (3), 15010863 (3), 12807916 (3), 10749120 (2) (see all 99)
    tyrosine 82 515 12429728 (4), 9178638 (4), 12369712 (4), 12627965 (3) (see all 99)
    phosphatidylinositol-3,4,5-trisphosphate 81.4 37 11592957 (1), 12218155 (1), 15465874 (1), 15728722 (1) (see all 26)
    sb 203580 77.8 85 10585868 (1), 12749833 (1), 14516785 (1), 15271999 (1) (see all 75)
    ly 303511 77.8 11 15923340 (2), 7744808 (1), 19614922 (1), 16644476 (1) (see all 8)

    Search CenterWatch for drugs/clinical trials and news about PIK3CG / PK3CG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PIK3CG gene (3 alternative transcripts): 
    NM_001282426.1  NM_001282427.1  NM_002649.3  

    Unigene Cluster for PIK3CG:

    Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
    Hs.32942  [show with all ESTs]
    Unigene Representative Sequence: X83368
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000440650 ENST00000496166(uc003vdv.4 uc003vdu.3) ENST00000473541
    ENST00000359195(uc003vdw.3) ENST00000466738
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIK3CG
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate PIK3CG (see all 10):
    hsa-miR-142-3p hsa-miR-502-5p hsa-miR-634 hsa-miR-922 hsa-miR-3166 hsa-miR-4255 hsa-miR-519e* hsa-miR-515-5p
    SwitchGear 3'UTR luciferase reporter plasmidPIK3CG 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PIK3CG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIK3CG
    Clone
    Products:
         
    OriGene clones in human, mouse for PIK3CG (see all 9)
    OriGene ORF clones in mouse, rat for PIK3CG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PIK3CG (NM_002649)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIK3CG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3CG
    Sirion Biotech Customized lentivirus for stable overexpression of PIK3CG 
                         Customized lentivirus expression plasmids for stable overexpression of PIK3CG 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PIK3CG
    OriGene qSTAR qPCR primer pairs in human, mouse for PIK3CG
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PIK3CG
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIK3CG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIK3CG

    Additional mRNA sequence: 

    AF327656.1 AK127860.1 AK292684.1 AK313753.1 AY496423.1 BC035683.1 BX648341.1 X83368.1 

    4 DOTS entries:

    DT.95288415  DT.455667  DT.100011720  DT.101974317 

    24/50 AceView cDNA sequences (see all 50):

    NM_002649 AF327656 AA448135 BQ232683 AA768557 BQ072706 BG257475 AA810265 
    N63285 BG392445 AA464176 BU152888 AA826284 AI969070 BG389556 X83368 
    BX648341 BX956229 AI656737 AA447993 BM920113 BX474515 N90358 AA767085 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PIK3CG    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c
    SP1:                    -                                                                           
    SP2:              -     -                                                                           
    SP3:                                                                                                


    ECgene alternative splicing isoforms for PIK3CG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PIK3CG expression in normal human tissues (normalized intensities)      PIK3CG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCTGATGA
    PIK3CG Expression
    About this image


    PIK3CG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Muscoskeletal System)    fully expand to see all 2 entries
             cd14+ cells   
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells ( Derivation and purification of endothelial precursor cells...
     
     Bone (Muscoskeletal System)
             BONE MARROW   
     
     Testis (Reproductive System)

    See PIK3CG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PIK3CG

    SOURCE GeneReport for Unigene cluster: Hs.32942

    UniProtKB/Swiss-Prot: PK3CG_HUMAN, P48736
    Tissue specificity: Pancreas, skeletal muscle, liver and heart

        SABiosciences Expression via Pathway-Focused PCR Arrays including PIK3CG (see all 6): 
              mTOR Signaling in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Adherens Junctions in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Autophagy in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PIK3CG
    OriGene qSTAR qPCR primer pairs in human, mouse for PIK3CG
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PIK3CG
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIK3CG
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIK3CG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3CG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PIK3CG gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pik3cg1 , 5 phosphoinositide-3-kinase, catalytic, gamma polypeptide1, 5 87.02(n)1
    94.1(a)1
      12 (13.74 cM)5
    309551  NM_001146200.11  NP_001139672.11 
     321734735 
    chicken
    (Gallus gallus)
    Aves PIK3CG1 phosphoinositide-3-kinase, catalytic, gamma polypeptide 75.83(n)
    85.03(a)
      417706  NM_001199538.1  NP_001186467.1 
    lizard
    (Anolis carolinensis)
    Reptilia PIK3CG6
    Uncharacterized protein
    81(a)
    1 ↔ 1
    5(97116435-97144628)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.347572 Xenopus laevis transcribed sequence with weak similarity more 74.1(n)    48025226 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb15d072 Danio rerio cDNA clone IMAGE6793295, partial cds 73.83(n)    BC057425.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pi3K92E6
    Pi3K92E
    27(a)
    1 → many
    3R(16454694-16460430)


    ENSEMBL Gene Tree for PIK3CG (if available)
    TreeFam Gene Tree for PIK3CG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PIK3CG gene
    PIK3C2B2  PIK3CD2  PIK3CA2  PIK3C2G2  PIK3C32  PIK3CB2  PIK3C2A2  
    7 SIMAP similar genes for PIK3CG using alignment to 3 protein entries:     PK3CG_HUMAN (see all proteins):
    PIK3C2G    PIK3CB    PIK3C2A    PIK3CA    PIK3CA variant protein    PIK3C2B
    PIK3CD

    PIK3CG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/757 SNPs in PIK3CG are shown (see all 757)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30747671,2
    C--106542693(+) CTGTC-/TTGTGTC 1 -- int10--------
    rs30747681,2
    C--106544193(+) ATTTT-/TTTT  
            
    ATTTA
    1 -- int11Minor allele frequency- TTTT:0.00NA 2
    rs47302061,2
    C--106544193(+) ATTTTA/TTTTAT 1 -- int11Minor allele frequency- T:0.00CSA 1
    rs751640981,2
    C--109863134(+) GCCAAA/GAGGCT 1 -- us2k10--------
    rs1423672651,2
    C--109863195(+) CCAGAC/TTGGGA 1 -- us2k10--------
    rs593506011,2
    C,F--109863205(+) ACTTGG/ACCCCC 1 -- us2k12Minor allele frequency- A:0.05WA 120
    rs1465078201,2
    --109863211(+) CCCCCC/TGGAAG 1 -- us2k10--------
    rs1154339651,2
    C,F--109863260(+) CTGGGG/AAACAG 1 -- us2k11Minor allele frequency- A:0.07WA 118
    rs1113202121,2
    C,F--109863382(+) GCAAGG/CTCTCA 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs2020908471,2
    C--109863467(+) AAGCT-/GCCAGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PIK3CG (106505723 - 106547592 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PIK3CG:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv507407CNV Insertion20534489


    Human Gene Mutation Database (HGMD): PIK3CG
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PIK3CG
    DNA2.0 Custom Variant and Variant Library Synthesis for PIK3CG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601232    OMIM disorders: --

    20/145 diseases for PIK3CG (see all 145):    About MalaCards
    tuberous sclerosis complex    myeloid leukemia    tuberous sclerosis    pancreatic ductal carcinoma
    keloids    large granular lymphocyte leukemia    waldenstrom macroglobulinemia    macroglobulinemia
    glioblastoma    hepatoblastoma    bile duct carcinoma    malignant glioma
    meningioma    angiosarcoma    benign tumors    thyroid cancer
    toxic encephalopathy    pandas    ataxia telangiectasia    polycythemia vera


    PIK3CG for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/90 Novoseek inferred disease relationships for PIK3CG gene (see all 90)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 60.1 244 17964232 (4), 17826033 (4), 15143962 (4), 18167534 (3) (see all 99)
    cancer 59.2 177 19275602 (4), 15143962 (4), 17964232 (3), 15933740 (3) (see all 99)
    prostate cancer 47.4 46 19787273 (3), 16651432 (3), 16253776 (3), 14559232 (2) (see all 33)
    glioblastoma 43.5 18 10962556 (3), 16763818 (2), 17616812 (1), 19158403 (1) (see all 13)
    insulin resistance 42.3 25 11788651 (2), 11779863 (2), 19622194 (2), 19914265 (2) (see all 19)
    inflammation 42.1 23 16567384 (2), 15907913 (1), 15878979 (1), 15537868 (1) (see all 22)
    breast cancer 42.1 77 16424042 (4), 19567590 (4), 12838322 (3), 16432178 (2) (see all 51)
    glioma 42 49 20116920 (4), 13130092 (2), 16828967 (2), 17102612 (2) (see all 27)
    necrosis 40.4 26 14970864 (2), 11168638 (1), 12925953 (1), 15878979 (1) (see all 22)
    leukemia 37.1 13 19550116 (2), 11489474 (1), 18684865 (1), 19143758 (1) (see all 12)

    Genetic Association Database (GAD): PIK3CG
    Human Genome Epidemiology (HuGE) Navigator: PIK3CG (15 documents)

    Export disorders for PIK3CG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PIK3CG gene, integrated from 9 sources (see all 2628):
    (articles sorted by number of sources associating them with PIK3CG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cardiac regulation by phosphoinositide 3-kinases and PTEN. (PubMed id 19147653)1, 2, 9 Oudit G.Y. and Penninger J.M. (2009)
    2. p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma. (PubMed id 15797027)1, 2, 9 Suire S....Stephens L. (2005)
    3. Targeting phosphoinositide 3-kinase gamma to fight inflammation and more. (PubMed id 18278175)1, 2, 9 Barberis L. and Hirsch E. (2008)
    4. Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis. (PubMed id 16094730)1, 2, 9 Naga Prasad S.V....Rockman H.A. (2005)
    5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    6. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    7. Physiogenomic analysis of statin-treated patients: do main-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (2010)
    8. Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (2010)
    9. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    10. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5294 HGNC: 8978 AceView: PIK3CG Ensembl:ENSG00000105851 euGenes: HUgn5294
    ECgene: PIK3CG Kegg: 5294 H-InvDB: PIK3CG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PIK3CG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PIK3CG Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PIK3CG gene:
    Search GeneIP for patents involving PIK3CG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore small molecules (inhibitor) for PIK3CG
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PIK3CG
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Purified and/or Recombinant PIK3CG Protein
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for PIK3CG (PI 3-Kinase p110 gamma)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PIK3CG   OriGene RNAi products in human, mouse, rat for PIK3CG  
     OriGene qPCR primer pairs and template standards for PIK3CG   OriGene Protein Over-expression Lysate for PIK3CG  
     OriGene MassSpec something-or-other for PIK3CG   OriGene clones in human, mouse for PIK3CG  
     OriGene qSTAR qPCR primer pairs in human, mouse for PIK3CG   OriGene Purified Protein for PIK3CG  
     OriGene ORF clones in mouse, rat for PIK3CG   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PIK3CG   OriGene Custom Protein Services for PIK3CG  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PIK3CG
     QIAGEN SeqTarget long-range PCR primers for resequencing PIK3CG
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIK3CG
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIK3CG
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIK3CG
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIK3CG
     GenScript Custom Purified and Recombinant Proteins Services for PIK3CG GenScript cDNA clones with any tag delivered in your preferred vector for PIK3CG
     GenScript Custom Assay Services for PIK3CG GenScript Custom Superior Antibodies Services for PIK3CG
     GenScript Custom overexpressing Cell Line Services for PIK3CG CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for PIK3CG 

     Regulatory tfbs in PIK3CG promoter
     Search Chromatin IP Primers for PIK3CG
     RT2 qPCR Primer Assay in human, mouse, rat PIK3CG
     GNC Network for PIK3CG
     SABiosciences PCR Arrays including human, mouse, rat PIK3CG
     Tocris compounds for PIK3CG
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs/Proteins for PIK3CG
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PIK3CG antibodies
     PIK3CG lysates
     Antibodies for PIK3CG
     See all of Abcam's Antibodies, Kits and Proteins for PIK3CG
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for PIK3CG




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for PIK3CG
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3CG
     SwitchGear 3'UTR luciferase reporter plasmids for PIK3CG
     SwitchGear Promoter luciferase reporter plasmids for PIK3CG
     ThermoFisher Antibodies for PIK3CG
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3CG
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PIK3CG
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PIK3CG
    Customized:
     lentivirus for stable overexpression of PIK3CG
     lentivirus expression plasmids for stable overexpression of PIK3CG
     adenovirus for overexpression of PIK3CG
     LSBio Antibodies in human, mouse, rat for PIK3CG
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PIK3CG gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4