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PIK3CG Gene

protein-coding   GIFtS: 71
GCID: GC07P106505

Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic...

(Previous names: phosphoinositide-3-kinase, catalytic, gamma polypeptide)
  See PIK3CG-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic Subunit
Gamma1 2
     PIK32
PtdIns-3-Kinase Subunit Gamma2 3     Phosphatidylinositol 3 Kinase Gamma, P110 Gamma2
PtdIns-3-Kinase Subunit P110-Gamma2 3     Phosphatidylinositol 3-Kinase Catalytic 110-KD Gamma2
Serine/Threonine Protein Kinase PIK3CG2 3     Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma
Isoform2
PI3Kgamma2 3     Phosphatidylinositol-4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit
Gamma2
p110gamma2 3     Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma
Isoform2
p120-PI3K2 3     Phosphoinositide-3-Kinase Gamma Catalytic Subunit2
PI3-Kinase Subunit Gamma2 3     EC 2.7.11.13
EC 2.7.1.1533 8     PI3K-gamma3
Phosphoinositide-3-Kinase, Catalytic, Gamma Polypeptide1     Phosphatidylinositol 4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit
Gamma3
1-Phosphatidylinositol 3-Kinase2     Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide3
PI3CG2     EC 2.7.18
PI3K2     

External Ids:    HGNC: 89781   Entrez Gene: 52942   Ensembl: ENSG000001058517   OMIM: 6012325   UniProtKB: P487363   

Export aliases for PIK3CG gene to outside databases

Previous GC identifers: GC07P104989 GC07P106052 GC07P106066 GC07P106099 GC07P106292 GC07P100864


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PIK3CG Gene:
This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme
that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator
of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an
important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in
promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of
cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified
in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene.
(provided by RefSeq, Sep 2013)

GeneCards Summary for PIK3CG Gene:
PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma) is a protein-coding gene. Diseases associated with PIK3CG include meningioma. GO annotations related to this gene include ephrin receptor binding and protein serine/threonine kinase activity. An important paralog of this gene is PIK3C2B.

UniProtKB/Swiss-Prot: PK3CG_HUMAN, P48736
Function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol
4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by
recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades
involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor
activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte
chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization
and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin
formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with
PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation.
Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together
with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling.
Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil
chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates
alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid
kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet
aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility.
Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels.
Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to ADRBK1
and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and
protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role
in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through
simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma
complex is activated by RAPGEF3 and which is involved in angiogenesis

summary for PIK3CG Gene:
PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the
3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of
cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell
migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric
consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and
delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst
p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have
recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes
(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI
3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to
play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3CG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PIK3CG gene promoter:
         MEF-2A   CREB   MEF-2   deltaCREB   STAT3   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIK3CG promoter sequence
   Search Chromatin IP Primers for PIK3CG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIK3CG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.3   Ensembl cytogenetic band:  7q22.3   HGNC cytogenetic band: 7q22

PIK3CG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIK3CG gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P106505:  view genomic region     (about GC identifiers)

Start:
106,505,723 bp from pter      End:
106,547,592 bp from pter
Size:
41,870 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 105,867,019-105,908,676     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PK3CG_HUMAN, P48736 (See protein sequence)
Recommended Name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform  
Size: 1102 amino acids; 126454 Da
Subunit: Heterodimer of a catalytic subunit PIK3CG and a PIK3R5 or PIK3R6 regulatory subunit. Interacts with
ADRBK1 through the PIK helical domain. Interaction with ADRBK1 is required for targeting to agonist-occupied
receptor. Interacts with PDE3B (By similarity). Interacts with TPM2. Interacts with EPHA8; regulates
integrin-mediated cell adhesion to substrate. Interacts with HRAS; the interaction is required for membrane
recruitment and beta-gamma G protein dimer-dependent activation of the PI3K gamma complex PIK3CG:PIK3R6 (By
similarity)
Miscellaneous: Candidate target in therapy for inflammatory diseases. Selective inhibitors and protein ablation
are anti-inflammatory in multiple disease models such as asthma, rheumatoid arthritis, allergy, systemic lupus
erythematosus, airway inflammation, lung injury and pancreatitis (PubMed:18278175)
Selected PDB 3D structures from and Proteopedia for PIK3CG (see all 72):
1E8Y (3D)        1E8Z (3D)        1HE8 (3D)        2A4Z (3D)        2A5U (3D)        2CHW (3D)    
Secondary accessions: A4D0Q6 Q8IV23 Q9BZC8

Explore the universe of human proteins at neXtProt for PIK3CG: NX_P48736

Explore proteomics data for PIK3CG at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PIK3CG (P48736) (see all 10)
     IGHFLFW  NVRAIAV  IVAKTYQ  SCAGYCV 


    See PIK3CG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001269355.1  NP_001269356.1  NP_002640.2  

    ENSEMBL proteins: 
     ENSP00000392258   ENSP00000419260   ENSP00000417623   ENSP00000352121  
    Reactome Protein details: P48736

    PIK3CG Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PIK3CG Protein
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    Enzo Life Sciences proteins for PIK3CG
    OriGene Purified Protein for PIK3CG
    OriGene Protein Over-expression Lysate for PIK3CG
    OriGene MassSpec for PIK3CG
    OriGene Custom Protein Services for PIK3CG
    GenScript Custom Purified and Recombinant Proteins Services for PIK3CG
    Novus Biologicals PIK3CG Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PIK3CG
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PIK3CG 

     
    Search antibodies-online for proteins for PIK3CG 

     
    antibodies-online peptides for PIK3CG

    PIK3CG Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PIK3CG
    R&D Systems Antibodies for PIK3CG (PI 3-Kinase p110 gamma)
    Cell Signaling Technology (CST) Antibodies for PIK3CG 
    OriGene Antibodies for PIK3CG
    OriGene Custom Antibody Services for PIK3CG
    Novus Biologicals PIK3CG Antibodies
    Abcam antibodies for PIK3CG
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for PIK3CG
    antibodies-online antibodies for PIK3CG (101 products) 

    PIK3CG Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PIK3CG 
    antibodies-online kits for PIK3CG (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
    Phosphatidylinositol-4,5-bisphosphate 3-kinase family

    Selected InterPro protein domains (see all 10):
     IPR001263 PInositide-3_kin_accessory_dom
     IPR003113 PI3K_adapt-bd_dom
     IPR002420 PI3K_C2_dom
     IPR011009 Kinase-like_dom
     IPR000403 PI3/4_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P48736

    ProtoNet protein and cluster: P48736

    2 Blocks protein domains:
    IPB000341 Phosphoinositide 3-kinase
    IPB000403 Phosphatidylinositol 3- and 4-kinase


    UniProtKB/Swiss-Prot: PK3CG_HUMAN, P48736
    Similarity: Belongs to the PI3/PI4-kinase family
    Similarity: Contains 1 C2 PI3K-type domain
    Similarity: Contains 1 PI3K-ABD domain
    Similarity: Contains 1 PI3K-RBD domain
    Similarity: Contains 1 PI3K/PI4K domain
    Similarity: Contains 1 PIK helical domain


    Find genes that share domains with PIK3CG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PK3CG_HUMAN, P48736
    Function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol
    4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by
    recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades
    involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor
    activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte
    chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization
    and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin
    formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with
    PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation.
    Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together
    with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling.
    Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil
    chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates
    alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid
    kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet
    aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility.
    Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels.
    Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to ADRBK1
    and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and
    protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role
    in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through
    simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma
    complex is activated by RAPGEF3 and which is involved in angiogenesis
    Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol
    3,4,5-trisphosphate
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by both the alpha and the beta-gamma G proteins following stimulation of G
    protein-coupled receptors (GPCRs). Activation by GPCRs is assisted by the regulatory subunits (PIK3R5 or PIK3R6)
    leading to the translocation from the cytosol to the plasma membrane and to kinase activation. Inhibited by
    AS-604850 and AS-605240

         Enzyme Numbers (IUBMB): EC 2.7.1.1531 2 EC 2.7.11.11 EC 2.7.12

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS19376709
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI12507995
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with PIK3CG           About GenesLikeMe


    Phenotypes:
         11 GenomeRNAi human phenotypes for PIK3CG:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella-containin  Decreased cilium length  Decreased cilium length after   Decreased focal adhesion (FA)  
     Decreased number of cells in m  Increased cell death HMECs cel  Increased cell death in breast 

         11 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Pik3cg):
     cardiovascular system  cellular  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  mortality/aging  muscle  skeleton 
     vision/eye 

    Find genes that share phenotypes with PIK3CG           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pik3cgtm1Pngr for PIK3CG

       genOway: Develop your customized and physiologically relevant rodent model for PIK3CG

    miRNA
    Products:
        
    miRTarBase miRNAs that target PIK3CG:
    hsa-mir-26b-5p (MIRT029342), hsa-mir-148b-3p (MIRT019349)

    Block miRNA regulation of human, mouse, rat PIK3CG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PIK3CG (see all 10):
    hsa-miR-142-3p hsa-miR-502-5p hsa-miR-634 hsa-miR-922 hsa-miR-3166 hsa-miR-4255 hsa-miR-519e* hsa-miR-515-5p
    SwitchGear 3'UTR luciferase reporter plasmidPIK3CG 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat PIK3CG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PIK3CG

    Clone
    Products:
         
    OriGene clones in human, mouse for PIK3CG (see all 9)
    OriGene ORF clones in mouse, rat for PIK3CG
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    GenScript: all cDNA clones in your preferred vector: PIK3CG (NM_002649)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIK3CG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3CG
    Addgene plasmids for PIK3CG 

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    eBioscience FlowRNA Probe Sets ( VA1-12246) for PIK3CG 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PK3CG_HUMAN, P48736: Cytoplasm. Cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    plasma membrane5
    mitochondrion2
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA12507995
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IBA--
    GO:0005942phosphatidylinositol 3-kinase complex ----
    GO:00059441-phosphatidylinositol-4-phosphate 3-kinase, class IB complex IDA12507995

    Find genes that share ontologies with PIK3CG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PIK3CG About   (see all 85)  
    See pathways by source

    SuperPathContained pathways About
    1Glioma
    Glioma0.51
    Prostate cancer0.39
    Non-small cell lung cancer0.51
    Signaling Pathways in Glioblastoma0.36
    Melanoma0.43
    2Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Chagas disease (American trypanosomiasis)0.32
    Toll-like receptor signaling pathway0.94
    Hepatitis B0.31
    Regulation of toll-like receptor signaling pathway0.93
    3PI Metabolism
    PI Metabolism0.65
    3-phosphoinositide biosynthesis0.47
    Synthesis of PIPs at the plasma membrane0.65
    4Inositol phosphate metabolism (KEGG)
    Inositol phosphate metabolism0.61
    superpathway of inositol phosphate compounds0.60
    Phosphatidylinositol signaling system0.61
    5Immune response Fc epsilon RI pathway
    Fc epsilon RI signaling pathway0.41
    VEGF - VEGF R2 Signaling Pathways0.35
    VEGF signaling pathway0.39


    Find genes that share SuperPaths with PIK3CG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for PIK3CG (see all 12)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    Akt Signaling Pathway

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PIK3CG
        CCR3 Pathway in Eosinophils
    Molecular Mechanisms of Cancer
    Ephrin-Eph Signaling
    Akt Signaling
    EphrinA-EphR Signaling

    1 Cell Signaling Technology (CST) Pathway for PIK3CG
        PI3K / Akt Signaling

    Selected Tocris Bioscience Pathways for PIK3CG (see all 9)
        Akt Pathway
    Insulin Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    Toll-like Receptor Pathway

    Selected GeneGo (Thomson Reuters) Pathways for PIK3CG (see all 15)
        Development EPO-induced MAPK pathway
    Cell adhesion Integrin inside-out signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Development ACM2 and ACM4 activation of ERK
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions

    Selected BioSystems Pathways for PIK3CG (see all 17)
        MicroRNAs in cardiomyocyte hypertrophy
    Focal Adhesion
    EGFR1 Signaling Pathway
    Insulin Signaling
    AMPK signaling

    3 Reactome Pathways for PIK3CG
        Synthesis of PIPs at the plasma membrane
    GPVI-mediated activation cascade
    G beta:gamma signalling through PI3Kgamma

    3 PharmGKB Pathways for PIK3CG
        Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Sorafenib Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for PIK3CG) (see all 62):
        Inositol phosphate metabolism
    ErbB signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    Chemokine signaling pathway

    UniProtKB/Swiss-Prot: PK3CG_HUMAN, P48736
    Pathway: Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PIK3CG (see all 6): 

              mTOR Signaling in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Adherens Junctions in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Autophagy in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PIK3CG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PIK3CG (P487361, 2, 3 ENSP000003521214) via UniProtKB, MINT, STRING, and/or I2D (see all 421)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 38):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001816cytokine production TAS19075988
    GO:0002250adaptive immune response TAS17290298
    GO:0002407dendritic cell chemotaxis TAS18278175
    GO:0002675positive regulation of acute inflammatory response IEA--

    Find genes that share ontologies with PIK3CG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for PIK3CG
      Browse compounds at ApexBio 

    Compounds for PIK3CG available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CZC 24832Selective inhibitor of PI 3-Kinase gamma[1159824-67-5]
    QuercetinNon-selective PI 3-kinase inhibitor[117-39-5]
    PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK [371935-74-9]
    AS 605240Potent and selective PI 3-kinase gamma (PI3Kgamma) inhibitor[648450-29-7]
    740 Y-PCell-permeable PI 3-kinase activator[1236188-16-1]

    Selected HMDB Compounds for PIK3CG (see all 382)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Phosphatidyl-D-myo-inositol1-Phosphatidyl-1D-myo-inositol (see all 6)----
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    PI(16:0/16:0)Phosphatidylinositol(32:0) (see all 8)----
    PI(16:0/16:1(9Z))Phosphatidylinositol(32:1) (see all 14)----
    PI(16:0/16:2(9Z,12Z))Phosphatidylinositol(16:0/16:2n4) (see all 18)----
    PI(16:0/18:0)Phosphatidylinositol(16:0/18:0) (see all 8)----
    PI(16:0/18:1(11Z))Phosphatidylinositol(16:0/18:1w7) (see all 14)----
    PI(16:0/18:1(9Z))Phosphatidylinositol(16:0/18:1) (see all 14)----
    PI(16:0/18:2(9Z,12Z))PIno(16:0/18:2) (see all 14)----

    Selected DrugBank Compounds for PIK3CG (see all 12)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Myricetin3,3',4,4',5',7-Hexahydro-2-phenyl-4H-chromen-4-one (see all 8)529-44-2target--17139284 17016423 10592235
    Staurosporine-- 62996-74-1target--17139284 17016423
    (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE-- --target--10592235
    (5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONE-- --target--10592235
    1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine-- --target--10592235
    2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE-- --target--10592235
    2-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-One-- 154447-36-6target--10592235
    3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL-- --target--10592235
    5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-one-- --target--10592235
    5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for PIK3CG gene (see all 126)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ly294002 98.3 1722 12788194 (4), 16397049 (4), 15752900 (3), 17302559 (3) (see all 99)
    wortmannin 96.5 1002 7875216 (6), 9182708 (6), 8010944 (5), 9489996 (4) (see all 99)
    phosphatidylinositol 96.3 1503 8106507 (9), 1325371 (6), 1323287 (6), 8999962 (6) (see all 99)
    phosphoinositide 92.4 529 18388257 (2), 20163786 (2), 15231713 (2), 18081863 (2) (see all 99)
    pd 98,059 90.4 228 14635227 (2), 12657249 (2), 20517899 (2), 10433244 (2) (see all 99)
    rapamycin 83.4 224 18660503 (3), 15010863 (3), 12807916 (3), 10749120 (2) (see all 99)
    tyrosine 82 515 12429728 (4), 9178638 (4), 12369712 (4), 12627965 (3) (see all 99)
    phosphatidylinositol-3,4,5-trisphosphate 81.4 37 11592957 (1), 12218155 (1), 15465874 (1), 15728722 (1) (see all 26)
    sb 203580 77.8 85 10585868 (1), 12749833 (1), 14516785 (1), 15271999 (1) (see all 75)
    ly 303511 77.8 11 15923340 (2), 7744808 (1), 19614922 (1), 16644476 (1) (see all 8)



    Find genes that share compounds with PIK3CG           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for PIK3CG gene (3 alternative transcripts): 
    NM_001282426.1  NM_001282427.1  NM_002649.3  

    Unigene Cluster for PIK3CG:

    Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
    Hs.32942  [show with all ESTs]
    Unigene Representative Sequence: X83368
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000440650 ENST00000496166(uc003vdv.4 uc003vdu.3) ENST00000473541
    ENST00000359195(uc003vdw.3) ENST00000466738
    miRNA
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    hsa-miR-142-3p hsa-miR-502-5p hsa-miR-634 hsa-miR-922 hsa-miR-3166 hsa-miR-4255 hsa-miR-519e* hsa-miR-515-5p
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    Addgene plasmids for PIK3CG 
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12246) for PIK3CG 

    Additional mRNA sequence: 

    AF327656.1 AK127860.1 AK292684.1 AK313753.1 AY496423.1 BC035683.1 BX648341.1 X83368.1 

    4 DOTS entries:

    DT.95288415  DT.455667  DT.100011720  DT.101974317 

    Selected AceView cDNA sequences (see all 50):

    NM_002649 BG257475 AA768557 BQ072706 AA448135 AA810265 BQ232683 AF327656 
    BX956229 AA885030 BM920113 BX648341 BX504620 X83368 N63285 BG392445 
    N90358 AK127860 AI656737 BC035683 BG389556 BU598381 AW576563 BX474515 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PIK3CG    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c
    SP1:                    -                                                                           
    SP2:              -     -                                                                           
    SP3:                                                                                                


    ECgene alternative splicing isoforms for PIK3CG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PIK3CG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCTGATGA
    PIK3CG Expression
    About this image


    PIK3CG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             Mature follicles
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells
     
     Testis (Reproductive System)
    PIK3CG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIK3CG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.32942

    UniProtKB/Swiss-Prot: PK3CG_HUMAN, P48736
    Tissue specificity: Pancreas, skeletal muscle, liver and heart

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PIK3CG (see all 6): 
              mTOR Signaling in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Adherens Junctions in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Autophagy in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat PIK3CG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3CG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PIK3CG gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pik3cg1 , 5 phosphoinositide-3-kinase, catalytic, gamma polypeptide1, 5 86.99(n)1
    94.1(a)1
      12 (13.74 cM)5
    309551  NM_001146201.11  NP_001139673.11 
     321734735 
    chicken
    (Gallus gallus)
    Aves PIK3CG1 phosphoinositide-3-kinase, catalytic, gamma polypeptide 75.59(n)
    84.75(a)
      417706  NM_001199538.1  NP_001186467.1 
    lizard
    (Anolis carolinensis)
    Reptilia PIK3CG6
    phosphatidylinositol-4,5-bisphosphate 3-kinase, ca...
    81(a)
    1 ↔ 1
    5(97116435-97144628)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.347572 Xenopus laevis transcribed sequence with weak similarity more 74.1(n)    48025226 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb15d072 Danio rerio cDNA clone IMAGE6793295, partial cds 73.83(n)    BC057425.1 
    worm
    (Caenorhabditis elegans)
    Secernentea age-16
    Protein AGE-1 (age-1) mRNA, complete cds
    24(a)
    1 ↔ 1
    II(11519499-11527062) WBGene00000090


    ENSEMBL Gene Tree for PIK3CG (if available)
    TreeFam Gene Tree for PIK3CG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PIK3CG gene
    PIK3C2B2  PIK3CD2  PIK3CA2  PIK3C2G2  PIK3C32  PIK3CB2  PIK3C2A2  
    7 SIMAP similar genes for PIK3CG using alignment to 3 protein entries:     PK3CG_HUMAN (see all proteins):
    PIK3C2G    PIK3CB    PIK3C2A    PIK3CA    PIK3CA variant protein    PIK3C2B
    PIK3CD

    Find genes that share paralogs with PIK3CG           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PIK3CG (see all 757)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30747671,2
    C--106542693(+) CTGTC-/TTGTGTC 1 -- int10--------
    rs30747681,2
    C--106544193(+) ATTTT-/TTTT  
            
    ATTTA
    1 -- int11Minor allele frequency- TTTT:0.00NA 2
    rs47302061,2
    C--106544193(+) ATTTTA/TTTTAT 1 -- int11Minor allele frequency- T:0.00CSA 1
    rs751640981,2
    C--109863134(+) GCCAAA/GAGGCT 1 -- us2k10--------
    rs1423672651,2
    C--109863195(+) CCAGAC/TTGGGA 1 -- us2k10--------
    rs593506011,2
    C,F--109863205(+) ACTTGG/ACCCCC 1 -- us2k12Minor allele frequency- A:0.05WA 120
    rs1465078201,2
    --109863211(+) CCCCCC/TGGAAG 1 -- us2k10--------
    rs1154339651,2
    C,F--109863260(+) CTGGGG/AAACAG 1 -- us2k11Minor allele frequency- A:0.07WA 118
    rs1113202121,2
    C,F--109863382(+) GCAAGG/CTCTCA 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs2020908471,2
    C--109863467(+) AAGCT-/GCCAGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PIK3CG (106505723 - 106547592 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PIK3CG:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv507407CNV Insertion20534489

    Human Gene Mutation Database (HGMD): PIK3CG
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PIK3CG
    DNA2.0 Custom Variant and Variant Library Synthesis for PIK3CG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601232    OMIM disorders: --

    1 disease for PIK3CG:    
    About MalaCards
    meningioma


    Find genes that share disorders with PIK3CG           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PIK3CG gene (see all 90)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 60.1 244 17964232 (4), 17826033 (4), 15143962 (4), 18167534 (3) (see all 99)
    cancer 59.2 177 19275602 (4), 15143962 (4), 17964232 (3), 15933740 (3) (see all 99)
    prostate cancer 47.4 46 19787273 (3), 16651432 (3), 16253776 (3), 14559232 (2) (see all 33)
    glioblastoma 43.5 18 10962556 (3), 16763818 (2), 17616812 (1), 19158403 (1) (see all 13)
    insulin resistance 42.3 25 11788651 (2), 11779863 (2), 19622194 (2), 19914265 (2) (see all 19)
    inflammation 42.1 23 16567384 (2), 15907913 (1), 15878979 (1), 15537868 (1) (see all 22)
    breast cancer 42.1 77 16424042 (4), 19567590 (4), 12838322 (3), 16432178 (2) (see all 51)
    glioma 42 49 20116920 (4), 13130092 (2), 16828967 (2), 17102612 (2) (see all 27)
    necrosis 40.4 26 14970864 (2), 11168638 (1), 12925953 (1), 15878979 (1) (see all 22)
    leukemia 37.1 13 19550116 (2), 11489474 (1), 18684865 (1), 19143758 (1) (see all 12)

    Genetic Association Database (GAD): PIK3CG
    Human Genome Epidemiology (HuGE) Navigator: PIK3CG (15 documents)

    Export disorders for PIK3CG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIK3CG gene, integrated from 10 sources (see all 2631):
    (articles sorted by number of sources associating them with PIK3CG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cardiac regulation by phosphoinositide 3-kinases and PTEN. (PubMed id 19147653)1, 2, 9 Oudit G.Y. and Penninger J.M. (Cardiovasc. Res. 2009)
    2. p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma. (PubMed id 15797027)1, 2, 9 Suire S....Stephens L. (Curr. Biol. 2005)
    3. Targeting phosphoinositide 3-kinase gamma to fight inflammation and more. (PubMed id 18278175)1, 2, 9 Barberis L. and Hirsch E. (Thromb. Haemost. 2008)
    4. Protein kinase activity of phosphoinositide 3-kinase regulates beta- adrenergic receptor endocytosis. (PubMed id 16094730)1, 2, 9 Naga Prasad S.V.... Rockman H.A. (Nat. Cell Biol. 2005)
    5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    6. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    7. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    8. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    9. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    10. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5294 HGNC: 8978 AceView: PIK3CG Ensembl:ENSG00000105851 euGenes: HUgn5294
    ECgene: PIK3CG Kegg: 5294 H-InvDB: PIK3CG

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PIK3CG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PIK3CG Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PIK3CG gene:
    Search GeneIP for patents involving PIK3CG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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