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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PIK3CG Gene

protein-coding GIFtS: 70
GCID: GC07P106505

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic...

(Previous names: phosphoinositide-3-kinase, catalytic, gamma polypeptide...)

Explore 171 diseases affiliated with
PIK3CG via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic Subunit Gamma¹ ²		PI3K²
Phosphoinositide-3-Kinase, Catalytic, Gamma Polypeptide¹ ²		PIK3²
Phosphatidylinositol 4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit Gamma² ³		P110-Gamma¹
PtdIns-3-Kinase Subunit Gamma² ³		Phosphatidylinositol 3 Kinase Gamma, P110 Gamma²
PtdIns-3-Kinase Subunit P110-Gamma² ³		Phosphatidylinositol 3-Kinase Catalytic 110-KD Gamma²
Serine/Threonine Protein Kinase PIK3CG² ³		Phosphatidylinositol 3-Kinase, Catalytic, Gamma Polypeptide²
PI3K-Gamma¹		Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform²
PI3Kgamma² ³		Phosphatidylinositol-4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit Gamma²
P110gamma¹		Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform²
P120-PI3K¹		Phosphoinositide-3-Kinase Gamma Catalytic Subunit²
PI3-Kinase Subunit Gamma² ³		EC 2.7.11.1³
EC 2.7.1.153³ ⁸		Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide³
1-Phosphatidylinositol 3-Kinase²		EC 2.7.1⁸
PI3CG²

External Ids:	HGNC: 8978¹	Entrez Gene: 5294²	Ensembl: ENSG00000105851⁷	OMIM: 601232⁵	UniProtKB: P48736³

Export aliases for PIK3CG gene to outside databases

Previous GC identifers: GC07P104989 GC07P106052 GC07P106066 GC07P106099 GC07P106292 GC07P100864

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PIK3CG:

This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that

phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of

extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important

role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting

assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK

cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PK3CG_HUMAN, P48736

Function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to

generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing

proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival,

proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in

immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to

chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of

PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls

motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration

towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and

cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte

development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is

involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and

thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12

through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in

platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility.

Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels.

Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to ADRBK1 and by

non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein

kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in

modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous

binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is

activated by RAPGEF3 and which is involved in angiogenesis

summary for PIK3CG:

PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the

3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of

cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell

migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric

consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and

delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst

p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have

recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes

(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI

3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to

play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3CG

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PIK3CG gene promoter:
MEF-2A CREB MEF-2 deltaCREB STAT3 aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PIK3CG promoter sequence

Search SABiosciences Chromatin IP Primers for PIK3CG

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIK3CG

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.3 Ensembl cytogenetic band: 7q22.3 HGNC cytogenetic band: 7q22

PIK3CG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIK3CG gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P106505: view genomic region (about GC identifiers)

Start:	106,505,723 bp from pter	End:	106,547,592 bp from pter
Size:	41,870 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 105,867,019-105,908,676

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PK3CG_HUMAN, P48736 (See protein sequence)

Recommended Name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Size: 1102 amino acids; 126454 Da

Subunit: Heterodimer of a catalytic subunit PIK3CG and a PIK3R5 or PIK3R6 regulatory subunit. Interacts with ADRBK1

through the PIK helical domain. Interaction with ADRBK1 is required for targeting to agonist-occupied receptor.

Interacts with PDE3B (By similarity). Interacts with TPM2. Interacts with EPHA8; regulates integrin-mediated cell

adhesion to substrate. Interacts with HRAS1; the interaction is required for membrane recruitment and beta-gamma G

protein dimer-dependent activation of the PI3K gamma complex PIK3CG:PIK3R6 (By similarity)

Subcellular location: Cytoplasm. Cell membrane

Miscellaneous: Candidate target in therapy for inflammatory diseases. Selective inhibitors and protein ablation are

anti-inflammatory in multiple disease models such as asthma, rheumatoid arthritis, allergy, systemic lupus

erythematosus, airway inflammation, lung injury and pancreatitis (PubMed:18278175)

6/62 PDB 3D structures from and Proteopedia for PIK3CG (see all 62):

1E8Y (3D)

1E8Z (3D)

1HE8 (3D)

2A4Z (3D)

2A5U (3D)

2CHW (3D)

Secondary accessions: A4D0Q6 Q8IV23 Q9BZC8

Explore the universe of human proteins at neXtProt for PIK3CG: NX_P48736

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P48736

4/10 DME Specific Peptides for PIK3CG (P48736) (see all 10)

IGHFLFW

NVRAIAV

SCAGYCV

IVAKTYQ

PIK3CG Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002640.2

ENSEMBL proteins:

ENSP00000392258 ENSP00000419260 ENSP00000417623 ENSP00000352121

Reactome Protein details: P48736
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant PIK3CG Protein
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for PIK3CG
	OriGene Purified Protein: PIK3CG OriGene Protein Over-expression Lysate: PIK3CG OriGene Custom Protein Services for PIK3CG
	GenScript Custom Purified and Recombinant Proteins Services for PIK3CG
	Novus Biologicals PIK3CG Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for PIK3CG
	Browse Proteins at Uscn

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	12507995
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	IEA	--
GO:0005944	1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex	IDA	12507995
GO:0016020	membrane	IDA	12507995

PIK3CG for ontologies About GeneDecksing

PIK3CG Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PIK3CG
	R&D Systems Antibodies for PIK3CG (PI 3-Kinase p110 gamma)
	Cell Signaling Technology (CST) Antibodies for PIK3CG
	OriGene Antibodies (see all 17): PIK3CG OriGene Custom Antibody Services for PIK3CG
	GenScript Custom Superior Antibodies Services for PIK3CG
	Novus Biologicals PIK3CG Antibodies
	Abcam antibodies for PIK3CG
	Browse Antibodies at Uscn
	ThermoFisher Antibody for PIK3CG

Assay Products for PIK3CG:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PIK3CG
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PIK3CG for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR001263 PInositide-3_kin_accessory_dom

IPR003113 PI3K_adapt-bd_dom

IPR002420 PI3K_C2_dom

IPR011009 Kinase-like_dom

IPR000403 PI3/4_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry P48736

ProtoNet protein and cluster: P48736

2 Blocks protein families:

IPB000341 Phosphoinositide 3-kinase

IPB000403 Phosphatidylinositol 3- and 4-kinase

UniProtKB/Swiss-Prot: PK3CG_HUMAN, P48736

Similarity: Belongs to the PI3/PI4-kinase family

Similarity: Contains 1 C2 PI3K-type domain

Similarity: Contains 1 PI3K-ABD domain

Similarity: Contains 1 PI3K-RBD domain

Similarity: Contains 1 PI3K/PI4K domain

Similarity: Contains 1 PIK helical domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary: