Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PIK3CD Gene

protein-coding   GIFtS: 71
GCID: GC01P009711

Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic...

(Previous names: phosphoinositide-3-kinase, catalytic, delta polypeptide)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic Subunit
Delta1 2
     p110D2
Phosphoinositide-3-Kinase C1 2     Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta
Isoform2
PtdIns-3-Kinase Subunit P110-Delta2 3     Phosphatidylinositol-4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit
Delta2
PI3Kdelta2 3     Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta
Isoform2
EC 2.7.1.1533 8     Phosphoinositide-3-Kinase, Catalytic, Delta Polypeptide Variant P37delta2
APDS2 5     PI3-Kinase P110 Subunit Delta2
IMD142 5     PI3K-delta3
catalytic1     p110delta3
Delta Polypeptide1     Phosphatidylinositol 4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit
Delta3
Phosphatidylinositol 3-Kinase1     PI3-Kinase Subunit Delta3
Phosphoinositide-3-Kinase, Catalytic, Delta Polypeptide1     PtdIns-3-Kinase Subunit Delta3
P110DELTA2     EC 2.7.18
PI3K2     

External Ids:    HGNC: 89771   Entrez Gene: 52932   Ensembl: ENSG000001716087   OMIM: 6028395   UniProtKB: O003293   

Export aliases for PIK3CD gene to outside databases

Previous GC identifers: GC01P009715 GC01P009555 GC01P009321 GC01P009421 GC01P009646 GC01P008867


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PIK3CD Gene:
Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The
protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks
(p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS.
However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.(provided by RefSeq,
Jul 2010)

GeneCards Summary for PIK3CD Gene:
PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta) is a protein-coding gene. Diseases associated with PIK3CD include activated pi3k-delta immunodeficiency syndrome, and mast-cell leukemia. GO annotations related to this gene include phosphatidylinositol 3-kinase activity and 1-phosphatidylinositol-3-kinase activity. An important paralog of this gene is PIK3C2B.

UniProtKB/Swiss-Prot: PK3CD_HUMAN, O00329
Function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol
4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by
recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades
involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a
role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling.
Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production
in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen
presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate
(S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells.
Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by
TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG
participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for
T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of
T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites
of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine
production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG
participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell
mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration.
Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for
its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK
phosphorylation and increased PI3K activity

summary for PIK3CD Gene:
PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the
3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of
cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell
migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric
consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and
delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst
p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have
recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes
(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI
3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to
play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3CD (P110δ) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PIK3CD gene promoter:
         Pax-5   GATA-3   Pax-2   FOXO3   Pax-2a   NF-kappaB   FOXO3b   NF-kappaB2   FOXO3a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PIK3CD promoter sequence
   Search Chromatin IP Primers for PIK3CD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIK3CD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.2   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.2

PIK3CD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIK3CD gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P009711:  view genomic region     (about GC identifiers)

Start:
9,711,790 bp from pter      End:
9,789,172 bp from pter
Size:
77,383 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PK3CD_HUMAN, O00329 (See protein sequence)
Recommended Name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform  
Size: 1044 amino acids; 119479 Da
Subunit: Heterodimer of a catalytic subunit PIK3CD and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3).
Interacts with ERAS (By similarity). Interacts with HRAS
Miscellaneous: IC87114 inhibitor reduces passive cutaneous anaphylaxis, attenuates allergic airway inflammation
and hyperresponsiveness and allergen induced rhinitis response. Inhibitors may have therapeutic potential for the
treatment of immune system-mediated diseases such as auto-immune diseases, inflammation and allergy
(PubMed:20940048; PubMed:17290298)
Secondary accessions: A6NCG0 G1FFP1 O15445 Q5SR49
Alternative splicing: 2 isoforms:  O00329-1   O00329-2   

Explore the universe of human proteins at neXtProt for PIK3CD: NX_O00329

Explore proteomics data for PIK3CD at MOPED

Post-translational modifications: 

  • Autophosphorylation on Ser-1039 results in the almost complete inactivation of the lipid kinase activity1
  • Ubiquitination2 at Lys46, Lys841
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PIK3CD (O00329) (see all 15)
     IGHFLFW  SCAGYCV  DLRQDML  LFHIDFG 


    See PIK3CD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005017.3  
    ENSEMBL proteins: 
     ENSP00000366563   ENSP00000354410   ENSP00000446444   ENSP00000443811  
    Reactome Protein details: O00329

    PIK3CD Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PIK3CD Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PIK3CD
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PIK3CD
    GenScript Custom Purified and Recombinant Proteins Services for PIK3CD
    Novus Biologicals PIK3CD Protein
    Novus Biologicals PIK3CD Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    PIK3CD Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PIK3CD
    R&D Systems Antibodies for PIK3CD (PI 3-Kinase p110 delta)
    OriGene Antibodies for PIK3CD
    OriGene Custom Antibody Services for PIK3CD
    Novus Biologicals PIK3CD Antibodies
    Abcam antibodies for PIK3CD
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for PIK3CD
    LSBio Antibodies in human, mouse, rat for PIK3CD

    PIK3CD Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PIK3CD
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PIK3CD
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
    Phosphatidylinositol-4,5-bisphosphate 3-kinase family

    Selected InterPro protein domains (see all 10):
     IPR001263 PInositide-3_kin_accessory_dom
     IPR003113 PI3K_adapt-bd_dom
     IPR002420 PI3K_C2_dom
     IPR011009 Kinase-like_dom
     IPR000403 PI3/4_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry O00329

    ProtoNet protein and cluster: O00329

    3 Blocks protein domains:
    IPB000341 Phosphoinositide 3-kinase
    IPB000403 Phosphatidylinositol 3- and 4-kinase
    IPB003113 Phosphatidylinositol 3-kinase


    UniProtKB/Swiss-Prot: PK3CD_HUMAN, O00329
    Similarity: Belongs to the PI3/PI4-kinase family
    Similarity: Contains 1 C2 PI3K-type domain
    Similarity: Contains 1 PI3K-ABD domain
    Similarity: Contains 1 PI3K-RBD domain
    Similarity: Contains 1 PI3K/PI4K domain
    Similarity: Contains 1 PIK helical domain


    PIK3CD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PK3CD_HUMAN, O00329
    Function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol
    4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by
    recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades
    involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a
    role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling.
    Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production
    in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen
    presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate
    (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells.
    Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by
    TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG
    participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for
    T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of
    T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites
    of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine
    production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG
    participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell
    mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration.
    Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for
    its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK
    phosphorylation and increased PI3K activity
    Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol
    3,4,5-trisphosphate
    Enzyme regulation: Activated by growth factors and cytokine receptors through a tyrosine-kinase-dependent
    mechanism. Activated by RAS. IC87114 inhibits lipid kinase activity and is selective in cells at doses up to 5-10
    uM. IC87114 blocks T-cell receptor signaling in naive and memory T-cells and reduces cytokine production by
    memory T-cells

         Genatlas biochemistry entry for PIK3CD:
    phosphatidylinositol 3-kinase,catalytic,class 1,delta,subunit,expressed in leukocytes,binding p85 adaptor proteins
    (PIK3R1,PIK3R2,PIK3R3) and associating with activated receptor protein-tyrosine kinases,regulating cellular
    responses

         Enzyme Numbers (IUBMB): EC 2.7.1.1531 2 EC 2.7.12

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
    GO:00163031-phosphatidylinositol-3-kinase activity NAS9235916
         
    PIK3CD for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PIK3CD:
     Decreased focal adhesion (FA)  

         9 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Pik3cd):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  hematopoietic system 
     homeostasis/metabolism  immune system  no phenotypic analysis  skeleton 

    PIK3CD for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PIK3CD: Pik3cdtm1Tnr Pik3cdtm1Jni

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PIK3CD
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PIK3CD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PIK3CD
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PIK3CD

    miRNA
    Products:
        
    miRTarBase miRNAs that target PIK3CD:
    hsa-mir-10b-5p (MIRT047463), hsa-mir-30a-5p (MIRT007097)

    Block miRNA regulation of human, mouse, rat PIK3CD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PIK3CD (see all 39):
    hsa-miR-576-3p hsa-miR-142-5p hsa-miR-513a-5p hsa-miR-30d hsa-miR-759 hsa-miR-29b-1* hsa-miR-30a hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmidPIK3CD 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PIK3CD
    Predesigned siRNA for gene silencing in human, mouse, rat PIK3CD

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PIK3CD

    Clone
    Products:
         
    OriGene clones in human, mouse for PIK3CD (see all 13)
    OriGene ORF clones in mouse, rat for PIK3CD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PIK3CD (NM_005026)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIK3CD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3CD

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PIK3CD
    Browse ESI BIO Cell Lines and PureStem Progenitors for PIK3CD 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3CD


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PK3CD_HUMAN, O00329: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    plasma membrane4
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0005942phosphatidylinositol 3-kinase complex NAS9113989
    GO:0042629mast cell granule TAS--

    PIK3CD for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PIK3CD About   (see all 99)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    VEGF signaling pathway0.39
    Immune response BCR pathway0.43
    VEGF - VEGF R2 Signaling Pathways0.35
    Fc epsilon RI signaling pathway0.41
    2Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    Immune response IL 4 signaling pathway0.39
    3IL-9 Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-15 Signaling Pathways0.88
    IL-7 Signaling Pathways0.90
    IL-4 Signaling Pathways0.84
    IL-21 Signaling Pathways0.90
    Immune response IL 9 signaling pathway0.42
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    Development Thrombopoietin regulated cell processes0.38
    4Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Development CNTF receptor signaling0.43
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Cell adhesion PLAU signaling0.35
    Transcription Receptor mediated HIF regulation0.51
    Transcription PPAR Pathway0.34
    Translation Regulation activity of EIF20.47
    mTOR signaling pathway0.34
    5Development HGF signaling pathway
    Development HGF signaling pathway0.45
    Apoptosis and survival Role of CDK5 in neuronal death and survival0.37
    Development Neurotrophin family signaling0.45
    Apoptosis and survival NGF signaling pathway0.36
    Development EGFR signaling via small GTPases0.44
    Neurotrophin signaling pathway0.36
    Development PDGF signaling via MAPK cascades0.41
    Apoptosis and survival Anti apoptotic action of membrane bound ESR10.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for PIK3CD (see all 12)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    Akt Signaling Pathway

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PIK3CD
        BAD Phosphorylation

    Selected Tocris Bioscience Pathways for PIK3CD (see all 9)
        Akt Pathway
    Insulin Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    Toll-like Receptor Pathway

    Selected GeneGo (Thomson Reuters) Pathways for PIK3CD (see all 65)
        G-protein signaling H-RAS regulation pathway
    Development A2A receptor signaling
    Development CNTF receptor signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway

    Selected BioSystems Pathways for PIK3CD (see all 16)
        MicroRNAs in cardiomyocyte hypertrophy
    Focal Adhesion
    EGFR1 Signaling Pathway
    Insulin Signaling
    G13 Signaling Pathway

    Selected Reactome Pathways for PIK3CD (see all 7)
        Interleukin receptor SHC signaling
    Interleukin-3, 5 and GM-CSF signaling
    Synthesis of PIPs at the plasma membrane
    Regulation of signaling by CBL
    Constitutive PI3K/AKT Signaling in Cancer

    3 PharmGKB Pathways for PIK3CD
        Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Sorafenib Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for PIK3CD) (see all 62):
        Inositol phosphate metabolism
    ErbB signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    Chemokine signaling pathway

    UniProtKB/Swiss-Prot: PK3CD_HUMAN, O00329
    Pathway: Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis


    PIK3CD for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PIK3CD: 

              mTOR Signaling in human mouse rat
              VEGF Signaling in human mouse rat
              Diabetes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PIK3CD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PIK3CD (O003291, 3 ENSP000003665634) via UniProtKB, MINT, STRING, and/or I2D (see all 237)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HRASP011121, 3, ENSP000003098454EBI-718309,EBI-350145 I2D: score=5 STRING: ENSP00000309845
    PIK3R2O004593, ENSP000002222544I2D: score=3 STRING: ENSP00000222254
    NCK1P163333, ENSP000002889864I2D: score=2 STRING: ENSP00000288986
    PIK3CGP487363, ENSP000003521214I2D: score=2 STRING: ENSP00000352121
    IL3P087003, ENSP000002968704I2D: score=1 STRING: ENSP00000296870
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001779natural killer cell differentiation TAS--
    GO:0001782B cell homeostasis IEA--
    GO:0001816cytokine production TAS--
    GO:0002250adaptive immune response TAS17290298
    GO:0002551mast cell chemotaxis TAS--

    PIK3CD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PIK3CD available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CZC 24832Selective inhibitor of PI 3-Kinase gamma[1159824-67-5]
    QuercetinNon-selective PI 3-kinase inhibitor[117-39-5]
    PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK [371935-74-9]
    AS 605240Potent and selective PI 3-kinase gamma (PI3Kgamma) inhibitor[648450-29-7]
    740 Y-PCell-permeable PI 3-kinase activator[1236188-16-1]

    Selected HMDB Compounds for PIK3CD (see all 382)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Phosphatidyl-D-myo-inositol1-Phosphatidyl-1D-myo-inositol (see all 6)----
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    PI(16:0/16:0)Phosphatidylinositol(32:0) (see all 8)----
    PI(16:0/16:1(9Z))Phosphatidylinositol(32:1) (see all 14)----
    PI(16:0/16:2(9Z,12Z))Phosphatidylinositol(16:0/16:2n4) (see all 18)----
    PI(16:0/18:0)Phosphatidylinositol(16:0/18:0) (see all 8)----
    PI(16:0/18:1(11Z))Phosphatidylinositol(16:0/18:1w7) (see all 14)----
    PI(16:0/18:1(9Z))Phosphatidylinositol(16:0/18:1) (see all 14)----
    PI(16:0/18:2(9Z,12Z))PIno(16:0/18:2) (see all 14)----

    1 DrugBank Compound for PIK3CD    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for PIK3CD gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphoinositide 88.2 26 12147247 (1), 12501193 (1), 15242973 (1), 19176369 (1) (see all 24)
    phosphatidylinositol-3,4,5-trisphosphate 78.3 3 9230105 (1), 17403925 (1), 18471983 (1)
    phosphatidylinositol 74.1 27 9235916 (3), 16341040 (1), 18377769 (1), 18332138 (1) (see all 21)
    ly294002 55.8 6 18332138 (1), 12849077 (1), 16702948 (1), 10064595 (1) (see all 5)
    tyrosine 39.7 11 7691885 (2), 15242973 (1), 10064595 (1), 19075915 (1) (see all 9)
    wortmannin 38 5 19106158 (1), 10064595 (1), 11252727 (1)
    lipid 36.7 10 10064595 (2), 16516442 (2), 17178602 (1), 19931507 (1) (see all 7)
    inositol 35.6 1 16516442 (1)
    threonine 32.8 4 16341040 (1), 19745197 (1), 12244133 (1), 16516442 (1)
    serine 17.5 4 16341040 (1), 12244133 (1), 12502714 (1), 16516442 (1)



    PIK3CD for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PIK3CD gene: 
    NM_005026.3  

    Unigene Cluster for PIK3CD:

    Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
    Hs.518451  [show with all ESTs]
    Unigene Representative Sequence: NM_005026
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377346 ENST00000484851 ENST00000361110 ENST00000481137 ENST00000479223
    ENST00000536656(uc001aqb.4 uc010oaf.2 uc021ogb.1 uc001aqe.4)
    ENST00000543390
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PIK3CD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PIK3CD (see all 39):
    hsa-miR-576-3p hsa-miR-142-5p hsa-miR-513a-5p hsa-miR-30d hsa-miR-759 hsa-miR-29b-1* hsa-miR-30a hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmidPIK3CD 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PIK3CD
    Predesigned siRNA for gene silencing in human, mouse, rat PIK3CD
    Clone
    Products:
         
    OriGene clones in human, mouse for PIK3CD (see all 13)
    OriGene ORF clones in mouse, rat for PIK3CD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PIK3CD (NM_005026)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIK3CD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3CD
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PIK3CD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PIK3CD
      QuantiTect SYBR Green Assays in human, mouse, rat PIK3CD
      QuantiFast Probe-based Assays in human, mouse, rat PIK3CD

    Additional mRNA sequence: 

    AB208835.1 AK303425.1 AK314191.1 BC030263.1 BC132919.1 BC132921.1 BC144264.1 BC150297.1 
    DQ263594.1 DQ263595.1 DQ263596.1 JN190435.1 U57843.1 U86453.1 Y10055.2 

    14 DOTS entries:

    DT.100816073  DT.121376768  DT.92454075  DT.102837436  DT.91751970  DT.95376344  DT.92454050  DT.97790994 
    DT.100816072  DT.121376620  DT.121376712  DT.91883164  DT.95283013  DT.303358 

    Selected AceView cDNA sequences (see all 207):

    AW501532 BQ641415 CA307257 CA306388 BC030263 AW235367 BQ677923 AW504513 
    BQ050479 AW205444 AW590419 AL699862 BM466963 BE327346 AI969548 BQ436769 
    AA047473 AW499827 BQ883233 BE048397 AL707253 AA281784 BQ683169 BU164465 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PIK3CD (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a ·
    SP1:              -           -     -                                   -                       -                                         -     -     -         
    SP2:                                                                    -           -           -                                         -                     
    SP3:                                                                                                                                      -     -     -         
    SP4:                                                                                                                                                            
    SP5:              -     -                                                                                                                                       

    ExUns: 15b ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27a · 27b
    SP1:              -                       -                                                                     
    SP2:              -                       -                                                                     
    SP3:                                                                                                            
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for PIK3CD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PIK3CD expression in normal human tissues (normalized intensities)      PIK3CD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCTGTCTG
    PIK3CD Expression
    About this image


    PIK3CD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
    PIK3CD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIK3CD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.518451

    UniProtKB/Swiss-Prot: PK3CD_HUMAN, O00329
    Tissue specificity: Isoform 2 is expressed in normal thymus, lung and spleen tissues, and is detected at low
    levels in normal lysates from colon and ovarian biopsies, at elevated levels in lysates from colorectal tumors
    and is abundantly expressed in some ovarian tumors (at protein level). Both isoform 1 and isoform 2 are widely
    expressed. Isoform 1 is expressed predominantly in leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PIK3CD: 
              mTOR Signaling in human mouse rat
              VEGF Signaling in human mouse rat
              Diabetes in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PIK3CD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PIK3CD
    QuantiTect SYBR Green Assays in human, mouse, rat PIK3CD
    QuantiFast Probe-based Assays in human, mouse, rat PIK3CD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3CD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for PIK3CD gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pik3cd1 , 5 phosphatidylinositol 3-kinase catalytic delta polypeptide1, 5 88.57(n)1
    94.64(a)1
      4 (80.15 cM)5
    187071  NM_008840.31  NP_032866.21 
     1496491685 
    chicken
    (Gallus gallus)
    Aves PIK3CD1 phosphoinositide-3-kinase, catalytic, delta polypeptide 76.89(n)
    82.17(a)
      419444  NM_001012696.1  NP_001012714.1 
    lizard
    (Anolis carolinensis)
    Reptilia PIK3CD6
    phosphatidylinositol-4,5-bisphosphate 3-kinase, ca...
    76(a)
    1 ↔ 1
    LGh(43576-98773)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc634732 similar to phosphoinositide-3-kinase, catalytic, delta more 75.82(n)   394174  BC054896.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pi3K92E1 , 3 insulin receptor signaling pathway
    phosphatidylinositol more3
    Pi3K92E1
    39(a)3
    53.18(n)1
    40.74(a)1
      92F33
    424461  NM_169910.21  NP_732536.11 


    ENSEMBL Gene Tree for PIK3CD (if available)
    TreeFam Gene Tree for PIK3CD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PIK3CD gene
    PIK3C2B2  PIK3CA2  PIK3C2G2  PIK3CG2  PIK3C32  PIK3CB2  PIK3C2A2  
    7 SIMAP similar genes for PIK3CD using alignment to 5 protein entries:     PK3CD_HUMAN (see all proteins):
    DKFZp779K1237    PIK3CB    DKFZp686G16234    PIK3CA    PIK3CA variant protein    PIK3C2A
    PIK3CG

    PIK3CD for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PIK3CD
    PGOHUM00000239970


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PIK3CD (see all 1713)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1136985471,2
    C--8915817(+) CTTTC-/TTTTTT 1 -- int11Minor allele frequency- T:0.00CSA 2
    rs348855741,2
    C--8926853(+) TGCTC-/AGAGAGA 1 -- int10--------
    rs726338651,2
    C,F--8926877(+) AGAGAC/GACAGA 1 -- int11Minor allele frequency- G:0.11NA 120
    rs744680241,2
    C--8926877(+) AGAGA-/CACAGAT
    AGACAGACA
    GACAG
    1 -- int10--------
    rs57723731,2
    C--9710192(+) GAATA-/GGGGCT 1 -- us2k10--------
    rs1154299081,2
    C--9727674(+) CACCAA/CCCCCA 1 -- us2k10--------
    rs768993651,2
    F--9727905(+) TGCATG/AGGAAT 1 -- us2k11Minor allele frequency- A:0.09WA 118
    rs42929651,2
    C,F,A--9728062(+) tgaggC/Tgggtg 1 -- us2k13Minor allele frequency- T:0.50NA 6
    rs1848428351,2
    --9728107(+) GAACAC/TGGCGA 1 -- us2k10--------
    rs45343871,2
    C,A--9728204(+) agaatC/Tgcttg 1 -- us2k18Minor allele frequency- T:0.07NA WA CSA 14

    HapMap Linkage Disequilibrium report for PIK3CD (9711790 - 9789172 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PIK3CD:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508847CNV Insertion20534489
    nsv160151CNV Loss16902084
    nsv832203CNV Loss17160897
    nsv871610CNV Gain21882294
    esv259473OTHER Complex20981092

    Human Gene Mutation Database (HGMD): PIK3CD
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PIK3CD
    DNA2.0 Custom Variant and Variant Library Synthesis for PIK3CD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602839   
    OMIM disorders: 615513  
    Selected diseases for PIK3CD (see all 54):    About MalaCards
    activated pi3k-delta immunodeficiency syndrome    mast-cell leukemia    megakaryocytic leukemia    systemic mastocytosis
    mastocytosis    toxic encephalopathy    cblc    trypanosomiasis
    toxoplasmosis    chagas disease    acute promyelocytic leukemia    measles
    brain disease    acute myeloid leukemia    myeloid leukemia    mantle cell lymphoma
    kaposi's sarcoma    chronic myeloid leukemia    medulloblastoma    hyperglycemia


    PIK3CD for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for PIK3CD gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 32.9 8 11772237 (2), 16341040 (1), 20197460 (1), 17568777 (1) (see all 5)
    autoimmunity 13.5 3 12669022 (1), 17598985 (1)
    glioblastoma 10.2 2 15605984 (1)
    breast cancer 0 2 12670921 (2)
    tumors 0 5 14655756 (2), 15605984 (1), 12670921 (1)
    allergy 0 1 19357769 (1)
    lymphoma 0 5 17371233 (2), 17215104 (1)
    immunodeficiency 0 6 16984281 (4), 12669022 (1)

    Genetic Association Database (GAD): PIK3CD
    Human Genome Epidemiology (HuGE) Navigator: PIK3CD (9 documents)

    Export disorders for PIK3CD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PIK3CD gene, integrated from 10 sources (see all 181):
    (articles sorted by number of sources associating them with PIK3CD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. P110delta, a novel phosphoinositide 3-kinase in leukocytes. (PubMed id 9113989)1, 2, 3, 9 Vanhaesebroeck B.A.M.... Waterfield M.D. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. Autophosphorylation of p110 delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo. (PubMed id 10064595)1, 2, 9 Vanhaesebroeck B.... Waterfield M.D. (EMBO J. 1999)
    3. PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans. (PubMed id 20081091)1, 2, 9 Soond D.R.... Okkenhaug K. (Blood 2010)
    4. p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. (PubMed id 9235916)1, 2, 9 Chantry D.... Hoekstra M.F. (J. Biol. Chem. 1997)
    5. Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer. (PubMed id 20197460)1, 4, 9 Koutros S....Berndt S.I. (Cancer Res. 2010)
    6. p37delta is a new isoform of PI3K p110delta that increases cell proliferation and is overexpressed in tumors. (PubMed id 22020336)1, 2 Fransson S.... Ejeskar K. (Oncogene 2012)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    9. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    10. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PubMed id 18996102)1, 4 RuaA+o G....Hanks S. ( international journal of clinical chemistry 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5293 HGNC: 8977 AceView: PIK3CD Ensembl:ENSG00000171608 euGenes: HUgn5293
    ECgene: PIK3CD Kegg: 5293 H-InvDB: PIK3CD

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PIK3CD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PIK3CD Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PIK3CD gene:
    Search GeneIP for patents involving PIK3CD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Purified and/or Recombinant PIK3CD Protein
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PIK3CD
     
     EMD Millipore genomic analysis products

      
     Antibodies for PIK3CD (PI 3-Kinase p110 delta)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PIK3CD   OriGene RNAi products in human, mouse, rat for PIK3CD  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PIK3CD  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PIK3CD  
     OriGene qSTAR qPCR primer pairs in human, mouse for PIK3CD   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PIK3CD   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PIK3CD   OriGene Custom Protein Services for PIK3CD  

     
     
     Block miRNA regulation of human, mouse, rat PIK3CD using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PIK3CD
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIK3CD Predesigned siRNA for gene silencing in human, mouse, rat PIK3CD
     QuantiFast Probe-based Assays in human, mouse, rat PIK3CD QuantiTect SYBR Green Assays in human, mouse, rat PIK3CD
     PCR Arrays including human, mouse, rat PIK3CD Search Chromatin IP Primers for PIK3CD
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PIK3CD  GeneGlobe Interaction Network for PIK3CD
     Regulatory tfbs in PIK3CD promoter
     GenScript Custom Purified and Recombinant Proteins Services for PIK3CD GenScript cDNA clones with any tag delivered in your preferred vector for PIK3CD
     GenScript Custom Assay Services for PIK3CD GenScript Custom overexpressing Cell Line Services for PIK3CD
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for PIK3CD
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PIK3CD antibodies
     PIK3CD proteins
     PIK3CD lysates
     Antibodies for PIK3CD
     See all of Abcam's Antibodies, Kits and Proteins for PIK3CD
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for PIK3CD
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3CD
     SwitchGear 3'UTR luciferase reporter plasmids for PIK3CD
     SwitchGear Promoter luciferase reporter plasmids for PIK3CD
     ThermoFisher Antibodies for PIK3CD
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3CD
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PIK3CD
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PIK3CD
     LSBio Antibodies in human, mouse, rat for PIK3CD
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PIK3CD gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4