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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PIK3CB Gene

protein-coding   GIFtS: 69
GCID: GC03M138372

Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic...

(Previous names: phosphoinositide-3-kinase, catalytic, beta polypeptide)
(Previous symbol: PIK3C1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic Subunit
Beta1 2
     PI3K2
PIK3C11 2 3     PI3KBETA2
Phosphoinositide-3-Kinase, Catalytic, Beta Polypeptide1 2     Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta
Isoform2
Phosphatidylinositol 4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit
Beta2 3
     Phosphatidylinositol-4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit
Beta2
PtdIns-3-Kinase Subunit Beta2 3     PI3-Kinase P110 Subunit Beta2
PtdIns-3-Kinase Subunit P110-Beta2 3     PtdIns-3-Kinase P1102
PI3K-beta2 3     PI3Kbeta3
PI3-Kinase Subunit Beta2 3     p110beta3
EC 2.7.1.1533 8     PI3KCB5
P110BETA2     EC 2.7.18

External Ids:    HGNC: 89761   Entrez Gene: 52912   Ensembl: ENSG000000513827   OMIM: 6029255   UniProtKB: P423383   

Export aliases for PIK3CB gene to outside databases

Previous GC identifers: GC03M135330 GC03M139174 GC03M139654 GC03M139693 GC03M139855 GC03M135748


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PIK3CB Gene:
This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are
important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for
their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown
to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or
infection. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Dec 2011)

GeneCards Summary for PIK3CB Gene: 
PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta) is a protein-coding gene. Diseases associated with PIK3CB include estrogen-receptor positive breast cancer, and tuberous sclerosis complex, and among its related super-pathways are Translation Insulin regulation of translation and Signal transduction AKT signaling. GO annotations related to this gene include insulin receptor substrate binding and phosphatidylinositol 3-kinase activity. An important paralog of this gene is PIK3C2B.

UniProtKB/Swiss-Prot: PK3CB_HUMAN, P42338
Function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P
(Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate
phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing
proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth,
survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by
G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid.
May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet
adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3
integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as
GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular
transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2
(TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of
autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and
activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively
regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase
activity is not required. May have a kinase-independent function in regulating cell proliferation and in
clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity
is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors

summary for PIK3CB Gene:
PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the
3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of
cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell
migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric
consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and
delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst
p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have
recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes
(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI
3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to
play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3CB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PIK3CB gene promoter:
         ER-alpha   POU3F1   FOXO3   Tal-1beta   FOXO3b   E47   PPAR-alpha   Hand1   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PIK3CB promoter sequence
   Search SABiosciences Chromatin IP Primers for PIK3CB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIK3CB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.3   Ensembl cytogenetic band:  3q22.3   HGNC cytogenetic band: 3q22.3

PIK3CB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIK3CB gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M138372:  view genomic region     (about GC identifiers)

Start:
138,372,860 bp from pter      End:
138,553,780 bp from pter
Size:
180,921 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PK3CB_HUMAN, P42338 (See protein sequence)
Recommended Name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform  
Size: 1070 amino acids; 122762 Da
Subunit: Heterodimer of a catalytic subunit PIK3CB and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3).
Interaction with PIK3R2 is required for nuclear localization and nuclear export. Part of a complex with PIK3R1
and PTEN. Binding to PTEN may antagonize the lipid kinase activity under normal growth conditions. Part of a
complex involved in autophagosome formation composed of PIK3C3 and PIK3R4 (By similarity). Interacts with BECN1,
ATG14 and RAB5A (By similarity)
Subcellular location: Cytoplasm. Nucleus. Note=Interaction with PIK3R2 is required for nuclear localization and
export
Secondary accessions: D3DNF0 Q24JU2

Explore the universe of human proteins at neXtProt for PIK3CB: NX_P42338

Explore proteomics data for PIK3CB at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Ser-1070 down-regulates lipid kinase activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P42338

  • 4/13 DME Specific Peptides for PIK3CB (P42338) (see all 13)
     SCAGYCV  DLRQDML  LFHIDFG  VDFLLPTG 

    PIK3CB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PIK3CB Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001242974.1  NP_006210.1  

    ENSEMBL proteins: 
     ENSP00000418143   ENSP00000419513   ENSP00000420108   ENSP00000417869   ENSP00000419091  
     ENSP00000418834   ENSP00000419857   ENSP00000420399   ENSP00000417329   ENSP00000289153  
     ENSP00000438259  
    Reactome Protein details: P42338
    Human Recombinant Protein Products for PIK3CB: 
    EMD Millipore Purified and/or Recombinant PIK3CB Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
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    Novus Biologicals PIK3CB Proteins
    Novus Biologicals PIK3CB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PIK3CB
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IBA--
    GO:0005942phosphatidylinositol 3-kinase complex IBA--

    PIK3CB for ontologies           About GeneDecksing



    PIK3CB Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PIK3CB
    R&D Systems Antibodies for PIK3CB (PI 3-Kinase p110 beta)
    Cell Signaling Technology (CST) Antibodies for PIK3CB 
    OriGene Antibodies for PIK3CB
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    Novus Biologicals PIK3CB Antibodies
    Abcam antibodies for PIK3CB
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    ThermoFisher Antibody for PIK3CB
    LSBio Antibodies in human, mouse, rat for PIK3CB 

    Assay Products for PIK3CB: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 
    Phosphatidylinositol-4,5-bisphosphate 3-kinase family

    5/10 InterPro protein domains (see all 10):
     IPR001263 PInositide-3_kin_accessory_dom
     IPR003113 PI3K_adapt-bd_dom
     IPR002420 PI3K_C2_dom
     IPR011009 Kinase-like_dom
     IPR000403 PI3/4_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P42338

    ProtoNet protein and cluster: P42338

    3 Blocks protein domains:
    IPB000341 Phosphoinositide 3-kinase
    IPB000403 Phosphatidylinositol 3- and 4-kinase
    IPB003113 Phosphatidylinositol 3-kinase


    UniProtKB/Swiss-Prot: PK3CB_HUMAN, P42338
    Domain: The inhibitory interactions with PIK3R1 are mediated by the PI3K-ABD domain and the C2 PI3K-type domain
    with the iSH2 (inter-SH2) region of PIK3R1; the C2 PI3K-type domain, the PI3K helical domain, and the PI3K/PI4K
    kinase domain with the nSH2 (N-terminal SH2) region of PIK3R1; and the PI3K/PI4K kinase domain with the cSH2
    (C-terminal SH2) region of PIK3R1. The inhibitory interaction between the PI3K-ABD domain and the C2 PI3K-type
    domain with the iSH2 (inter-SH2) region of PIK3R1 is weak. The nuclear localization signal (NLS) is required for
    its function in cell survival
    Similarity: Belongs to the PI3/PI4-kinase family
    Similarity: Contains 1 C2 PI3K-type domain
    Similarity: Contains 1 PI3K-ABD domain
    Similarity: Contains 1 PI3K-RBD domain
    Similarity: Contains 1 PI3K/PI4K domain
    Similarity: Contains 1 PIK helical domain


    PIK3CB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PK3CB_HUMAN, P42338
    Function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P
    (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate
    phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing
    proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth,
    survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by
    G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid.
    May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet
    adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3
    integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as
    GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular
    transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2
    (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of
    autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and
    activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively
    regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase
    activity is not required. May have a kinase-independent function in regulating cell proliferation and in
    clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity
    is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors
    Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol
    3,4,5-trisphosphate

         Enzyme Numbers (IUBMB): EC 2.7.1.1531 2 EC 2.7.12

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI19380743
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
    GO:00163031-phosphatidylinositol-3-kinase activity IBA--
         
    PIK3CB for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for PIK3CB:
     Decreased cilium length after   Decreased influenza A/WSN/33 r  Increased HPV18 LCR reporter a  Increased cell death in breast 
     Upregulation of Wnt/beta-caten 

         10 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Pik3cb):
     cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland  growth/size 
     hematopoietic system  homeostasis/metabolism  integument  mortality/aging  tumorigenesis 

    PIK3CB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PIK3CB: Pik3cbtm1.1Bvan Pik3cbtm1Nbm

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PIK3CB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PIK3CB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PIK3CB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PIK3CB 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIK3CB
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    Inhib. RNA
    Products:
        
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    Gene Editing
    Products:
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    Clone
    Products:
         
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    GenScript: all cDNA clones in your preferred vector: PIK3CB (NM_006219)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3CB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PIK3CB About   (see all 113)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Development CNTF receptor signaling0.43
    Regulation of lipid metabolism Insulin signaling:generic cascades0.59
    Cell adhesion PLAU signaling0.35
    Transcription Receptor-mediated HIF regulation0.51
    mTOR signaling pathway0.34
    Translation Regulation activity of EIF20.47
    Insulin signaling pathway0.31
    2Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    3Development Prolactin receptor signaling
    Development Prolactin receptor signaling0.39
    Prolactin signaling pathway0.33
    Prolactin Signaling Pathway0.39
    4Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-2 Signaling Pathways0.88
    IL-7 Signaling Pathways0.90
    IL-4 Signaling Pathways0.84
    IL-21 Signaling Pathways0.90
    Immune response IL-9 signaling pathway0.42
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    Development Thrombopoietin-regulated cell processes0.38
    5Development HGF signaling pathway
    Development HGF signaling pathway0.78
    Apoptosis and survival Role of CDK5 in neuronal death and survival0.37
    Development Neurotrophin family signaling0.45
    Apoptosis and survival NGF signaling pathway0.36
    Development EGFR signaling via small GTPases0.44
    Neurotrophin signaling pathway0.36
    Development PDGF signaling via MAPK cascades0.41
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR10.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/66 EMD Millipore Pathways for PIK3CB (see all 66)
        Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling FAK signaling
    Cytoskeleton remodeling Role of PDGFs in cell migration

    5/12 R&D Systems Pathways for PIK3CB (see all 12)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    Akt Signaling Pathway


    1 Cell Signaling Technology (CST) Pathway for PIK3CB
        PI3K / Akt Signaling

    5/9 Tocris Bioscience Pathways for PIK3CB (see all 9)
        Akt Pathway
    Insulin Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    Toll-like Receptor Pathway

    5/67 GeneGo (Thomson Reuters) Pathways for PIK3CB (see all 67)
        G-protein signaling H-RAS regulation pathway
    Development A2A receptor signaling
    Development CNTF receptor signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway

    5/26 BioSystems Pathways for PIK3CB (see all 26)
        MicroRNAs in cardiomyocyte hypertrophy
    Focal Adhesion
    EGFR1 Signaling Pathway
    G13 Signaling Pathway
    Insulin Signaling

    5/61        Reactome Pathways for PIK3CB (see all 61)
        Nephrin interactions
    Signaling by EGFR in Cancer
    Downstream signal transduction
    IRS-mediated signalling
    Signal Transduction

    3 PharmGKB Pathways for PIK3CB
        Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Sorafenib Pharmacodynamics

    5/55         Kegg Pathways  (Kegg details for PIK3CB) (see all 55):
        Inositol phosphate metabolism
    ErbB signaling pathway
    Chemokine signaling pathway
    HIF-1 signaling pathway
    Phosphatidylinositol signaling system

    UniProtKB/Swiss-Prot: PK3CB_HUMAN, P42338
    Pathway: Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis


    PIK3CB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIK3CB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/187 Interacting proteins for PIK3CB (P423381, 2, 3 ENSP000002891534) via UniProtKB, MINT, STRING, and/or I2D (see all 187)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HCKP086311, 3, ENSP000003650124EBI-2609540,EBI-346340 I2D: score=2 STRING: ENSP00000365012
    HPS6Q86YV92, 3, ENSP000002992384MINT-8266172 I2D: score=2 STRING: ENSP00000299238
    PIK3R2O004591, 3, ENSP000002222544EBI-2609540,EBI-346930 I2D: score=1 STRING: ENSP00000222254
    YWHAQP273482, 3, ENSP000002380814MINT-16257 MINT-16256 I2D: score=3 STRING: ENSP00000238081
    DVL3Q929972, 3, ENSP000003160544MINT-8266161 I2D: score=2 STRING: ENSP00000316054
    About this table

    Gene Ontology (GO): 5/32 biological process terms (GO ID links to tree view) (see all 32):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity TAS10570282
    GO:0001952regulation of cell-matrix adhesion IEA--
    GO:0006644phospholipid metabolic process TAS--
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0006874cellular calcium ion homeostasis IEA--

    PIK3CB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PIK3CB for compounds           About GeneDecksing

    EMD Millipore small molecules for PIK3CB:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for PIK3CB

    Compounds for PIK3CB available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CZC 24832Selective inhibitor of PI 3-Kinase gamma[1159824-67-5]
    QuercetinNon-selective PI 3-kinase inhibitor[117-39-5]
    PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK [371935-74-9]
    AS 605240Potent and selective PI 3-kinase gamma (PI3Kgamma) inhibitor[648450-29-7]
    740 Y-PCell-permeable PI 3-kinase activator[1236188-16-1]

    10/382 HMDB Compounds for PIK3CB (see all 382)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Phosphatidyl-D-myo-inositol1-Phosphatidyl-1D-myo-inositol (see all 6)----
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    PI(16:0/16:0)Phosphatidylinositol(32:0) (see all 8)----
    PI(16:0/16:1(9Z))Phosphatidylinositol(32:1) (see all 14)----
    PI(16:0/16:2(9Z,12Z))Phosphatidylinositol(16:0/16:2n4) (see all 18)----
    PI(16:0/18:0)Phosphatidylinositol(16:0/18:0) (see all 8)----
    PI(16:0/18:1(11Z))Phosphatidylinositol(16:0/18:1w7) (see all 14)----
    PI(16:0/18:1(9Z))Phosphatidylinositol(16:0/18:1) (see all 14)----
    PI(16:0/18:2(9Z,12Z))PIno(16:0/18:2) (see all 14)----

    10/38 Novoseek inferred chemical compound relationships for PIK3CB gene (see all 38)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphoinositide 88.2 74 18285463 (2), 14767610 (2), 15194438 (1), 17021257 (1) (see all 60)
    phosphatidylinositol 87.2 116 11016459 (3), 9761720 (1), 9824294 (1), 12734380 (1) (see all 99)
    wortmannin 81.9 52 9162091 (2), 8547643 (2), 15048882 (2), 11241349 (1) (see all 40)
    phosphatidylinositol-3,4,5-trisphosphate 76.1 5 17911247 (1), 9822674 (1), 19689267 (1), 20197379 (1) (see all 5)
    rapamycin 64 22 15048882 (3), 15708965 (2), 15209374 (2), 16841034 (1) (see all 14)
    ly294002 60.5 15 18718566 (1), 9337861 (1), 16546986 (1), 18653476 (1) (see all 11)
    phosphatidylinositol 3-phosphate 55.1 4 18843041 (2), 18802925 (1)
    tyrosine 53.8 28 20231295 (2), 10362672 (1), 9256157 (1), 18285463 (1) (see all 25)
    lipid 50.8 59 10947948 (5), 11278889 (3), 9824294 (2), 10698680 (2) (see all 35)
    pkcs 45.3 2 20179209 (2)

    Search CenterWatch for drugs/clinical trials and news about PIK3CB / PK3CB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PIK3CB gene (2 alternative transcripts): 
    NM_001256045.1  NM_006219.2  

    Unigene Cluster for PIK3CB:

    Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
    Hs.239818  [show with all ESTs]
    Unigene Representative Sequence: NM_006219
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477593 ENST00000469284 ENST00000462898 ENST00000481749(uc011bmn.2)
    ENST00000493568 ENST00000487552 ENST00000473435 ENST00000485060 ENST00000462294
    ENST00000483968 ENST00000461451 ENST00000465581 ENST00000289153(uc011bmo.2 uc011bmp.2 uc011bmq.2)
    ENST00000544716
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK293754.1 AK302937.1 BC003393.1 BC022049.2 BC033948.2 BC035432.2 BC045790.1 BC114432.1 
    CR749357.1 S67334.1 

    10 DOTS entries:

    DT.100761754  DT.455585  DT.91983273  DT.91746382  DT.95359332  DT.95376428  DT.100008223  DT.100761758 
    DT.95141049  DT.40288977 

    24/160 AceView cDNA sequences (see all 160):

    AI336926 AI955905 AL528255 BM786028 AW951418 BC003393 AW769150 BM557370 
    CA446594 CR595543 CA430309 S67334 CR749357 BX115428 AA782818 AI627546 
    AI349100 AA916375 BC035432 BF223707 BM128081 CA420622 NM_006219 AI150901 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PIK3CB expression in normal human tissues (normalized intensities)      PIK3CB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PIK3CB Expression
    About this image


    PIK3CB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...

     -- (Respiratory System)
             visceral organ   

    See PIK3CB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PIK3CB

    SOURCE GeneReport for Unigene cluster: Hs.239818

    UniProtKB/Swiss-Prot: PK3CB_HUMAN, P42338
    Tissue specificity: Expressed ubiquitously

        SABiosciences Expression via Pathway-Focused PCR Arrays including PIK3CB: 
              mTOR Signaling in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              VEGF Signaling in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PIK3CB gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pik3cb1 , 5 phosphatidylinositol 3-kinase, catalytic, beta polypeptide1, 5 88.44(n)1
    95.86(a)1
      9 (51.41 cM)5
    747691  NM_029094.31  NP_083370.21 
     990384025 
    chicken
    (Gallus gallus)
    Aves PIK3CB1 phosphoinositide-3-kinase, catalytic, beta polypeptide 80.2(n)
    87.12(a)
      424826  NM_001031311.1  NP_001026482.1 
    lizard
    (Anolis carolinensis)
    Reptilia PIK3CB6
    Uncharacterized protein
    86(a)
    1 ↔ 1
    3(27824432-27931495)
    zebrafish
    (Danio rerio)
    Actinopterygii pik3cb1 phosphoinositide-3-kinase, catalytic, beta polypeptide 66.95(n)
    69.32(a)
      100002263  XM_001923222.3  XP_001923257.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pi3K92E1 , 3 insulin receptor signaling pathway
    phosphatidylinositol more3
    CG4141-PA1
    37(a)3
    47.84(n)1
    39.65(a)1
      92F33
    424461  NM_142645.21  NP_650902.11 


    ENSEMBL Gene Tree for PIK3CB (if available)
    TreeFam Gene Tree for PIK3CB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PIK3CB gene
    PIK3C2B2  PIK3CD2  PIK3CA2  PIK3C2G2  PIK3CG2  PIK3C32  PIK3C2A2  
    11 SIMAP similar genes for PIK3CB using alignment to 10 protein entries:     PK3CB_HUMAN (see all proteins):
    DKFZp779K1237    PIK3CD    PIK3C2B variant protein    PIK3CA variant protein    DKFZp686G16234    PIK3C2B
    PIK3C2G    PIK3CA    PIK3CG    PIK3C2A    PIK3C3

    PIK3CB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2005 SNPs in PIK3CB are shown (see all 2005)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1414173541,2
    --138371110(+) GGGGGC/TTCCAC 2 -- int10--------
    rs790942811,2
    C--138371251(+) ACCTCC/TGCCTC 2 -- int10--------
    rs787078351,2
    C--138371252(+) CCTCCG/TCCTCC 2 -- int10--------
    rs789497141,2
    C--138371253(+) CTCCGC/GCTCCT 2 -- int10--------
    rs1815902141,2
    --138371513(+) AATAAC/GATCTA 2 -- int10--------
    rs1392493211,2
    --138371550(+) ATAGTC/TGATAA 2 -- ut310--------
    rs6240991,2
    C,F,A,H--138371699(+) atgtaT/Ccccat 2 -- ut3113Minor allele frequency- C:0.42MN NS EA NA WA CSA 956
    rs1866531261,2
    --138371773(+) CTCTGA/GTGATG 2 -- ut310--------
    rs1453163681,2
    --138371898(+) AAACAC/TAGAAT 2 -- ut310--------
    rs1167673371,2
    --138371918(+) CATTGC/TGGATA 2 -- ut311Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for PIK3CB (138372860 - 138553780 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PIK3CB:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2571713CNV Deletion19546169
    esv269442CNV Insertion20981092
    esv271132CNV Insertion20981092
    nsv428422CNV Gain+Loss18775914


    Human Gene Mutation Database (HGMD): PIK3CB
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602925    OMIM disorders: --

    20/58 diseases for PIK3CB (see all 58):    About MalaCards
    estrogen-receptor positive breast cancer    tuberous sclerosis complex    toxic encephalopathy    cblc
    trypanosomiasis    keloids    chagas disease    toxoplasmosis
    hyperglycemia    tuberous sclerosis    barrett's esophagus    wiskott-aldrich syndrome
    measles    acute promyelocytic leukemia    insulin resistance    chondrosarcoma
    gout    brain disease    chronic myeloid leukemia    choriocarcinoma


    PIK3CB for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/20 Novoseek inferred disease relationships for PIK3CB gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 37.8 34 18755892 (6), 19962660 (3), 10956212 (2), 16772787 (1) (see all 17)
    colon cancer 23.2 6 16772787 (2), 11042696 (2)
    tumors 22.4 18 16772787 (2), 19805051 (2), 20103642 (2), 14767610 (2) (see all 10)
    metastasis 4.1 2 14767610 (1), 17169389 (1)
    leukemia 0 2 16239435 (1)
    carcinoma squamous cell 0 1 14767610 (1)
    insulin resistance 0 2 12231075 (1), 20107106 (1)
    asthma 0 2 19689267 (1), 12529321 (1)
    inflammation 0 3 17021257 (1), 16085391 (1), 12529321 (1)
    glioma 0 1 16700623 (1)

    Genetic Association Database (GAD): PIK3CB
    Human Genome Epidemiology (HuGE) Navigator: PIK3CB (19 documents)

    Export disorders for PIK3CB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PIK3CB gene, integrated from 9 sources (see all 407):
    (articles sorted by number of sources associating them with PIK3CB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85. (PubMed id 8246984)1, 2, 3 Hu P.... Schlessinger J. (1993)
    2. PTEN-deficient cancers depend on PIK3CB. (PubMed id 18755892)1, 2, 9 Wee S....Lengauer C. (2008)
    3. Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase: cloning, genomic structure, and screening for variants in patients with type 2 diabetes. (PubMed id 11016459)2, 4, 9 Kossila M....Laakso M. (2000)
    4. Impact of rs361072 in the phosphoinositide 3-kinase p 110beta gene on whole-body glucose metabolism and subunit protein expression in skeletal muscle. (PubMed id 20107106)1, 4, 9 Ribel-Madsen R....Vaag A. (2010)
    5. Mutation analysis of PIK3CA and PIK3CB in esophageal cancer and Barrett's esophagus. (PubMed id 16380997)1, 4, 9 Phillips W.A....Campbell I.G. (2006)
    6. Nuclear but not cytosolic phosphoinositide 3-kinase b eta has an essential function in cell survival. (PubMed id 21383062)1, 2 Kumar A....Carrera A.C. (2011)
    7. Genetic associations of brain structural networks in schizophrenia: a preliminary study. (PubMed id 20691427)1, 4 Jagannathan K....Pearlson G.D. (2010)
    8. A beta version of life: p110I^ takes center stage. (PubMed id 21321382)1, 2 Dbouk H.A. and Backer J.M. (2010)
    9. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    10. Physiogenomic analysis of statin-treated patients: do main-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5291 HGNC: 8976 AceView: PIK3CB Ensembl:ENSG00000051382 euGenes: HUgn5291
    ECgene: PIK3CB Kegg: 5291 H-InvDB: PIK3CB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PIK3CB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PIK3CB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PIK3CB gene:
    Search GeneIP for patents involving PIK3CB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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     ThermoFisher Antibody for PIK3CB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3CB
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PIK3CB
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PIK3CB
    Customized:
     lentivirus for stable overexpression of PIK3CB
     lentivirus expression plasmids for stable overexpression of PIK3CB
     adenovirus for overexpression of PIK3CB
     LSBio Antibodies in human, mouse, rat for PIK3CB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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