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Aliases for PIK3CB Gene

Aliases for PIK3CB Gene

  • Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic Subunit Beta 2 3
  • Phosphatidylinositol 4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit Beta 3 4
  • Phosphoinositide-3-Kinase, Catalytic, Beta Polypeptide 2 3
  • PtdIns-3-Kinase Subunit P110-Beta 3 4
  • PtdIns-3-Kinase Subunit Beta 3 4
  • PI3-Kinase Subunit Beta 3 4
  • EC 2.7.1.153 4 63
  • PI3K-Beta 3 4
  • P110BETA 3 4
  • PI3KBETA 3 4
  • PIK3C1 3 4
  • Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform 3
  • Phosphatidylinositol-4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit Beta 3
  • PI3-Kinase P110 Subunit Beta 3
  • PtdIns-3-Kinase P110 3
  • EC 2.7.1 63
  • PI3KCB 6
  • PI3K 3

External Ids for PIK3CB Gene

Previous HGNC Symbols for PIK3CB Gene

  • PIK3C1

Previous GeneCards Identifiers for PIK3CB Gene

  • GC03M135330
  • GC03M139174
  • GC03M139654
  • GC03M139693
  • GC03M139855
  • GC03M138372
  • GC03M135748

Summaries for PIK3CB Gene

Entrez Gene Summary for PIK3CB Gene

  • This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

GeneCards Summary for PIK3CB Gene

PIK3CB (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic Subunit Beta) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include insulin receptor substrate binding and 1-phosphatidylinositol-4-phosphate 3-kinase activity. An important paralog of this gene is PIK3C3.

UniProtKB/Swiss-Prot for PIK3CB Gene

  • Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors.

Tocris Summary for PIK3CB Gene

  • PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes (C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI 3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3CB Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIK3CB Gene

Genomics for PIK3CB Gene

Regulatory Elements for PIK3CB Gene

Genomic Location for PIK3CB Gene

Start:
138,652,698 bp from pter
End:
138,834,938 bp from pter
Size:
182,241 bases
Orientation:
Minus strand

Genomic View for PIK3CB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIK3CB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIK3CB Gene

Proteins for PIK3CB Gene

  • Protein details for PIK3CB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42338-PK3CB_HUMAN
    Recommended name:
    Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
    Protein Accession:
    P42338
    Secondary Accessions:
    • D3DNF0
    • Q24JU2

    Protein attributes for PIK3CB Gene

    Size:
    1070 amino acids
    Molecular mass:
    122762 Da
    Quaternary structure:
    • Heterodimer of a catalytic subunit PIK3CB and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interaction with PIK3R2 is required for nuclear localization and nuclear export. Part of a complex with PIK3R1 and PTEN. Binding to PTEN may antagonize the lipid kinase activity under normal growth conditions. Part of a complex involved in autophagosome formation composed of PIK3C3 and PIK3R4 (By similarity). Interacts with BECN1, ATG14 and RAB5A (By similarity).

neXtProt entry for PIK3CB Gene

Proteomics data for PIK3CB Gene at MOPED

Post-translational modifications for PIK3CB Gene

  • Phosphorylation at Ser-1070 down-regulates lipid kinase activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for PIK3CB Gene

Suggested Antigen Peptide Sequences for PIK3CB Gene

Graphical View of Domain Structure for InterPro Entry

P42338

UniProtKB/Swiss-Prot:

PK3CB_HUMAN :
  • P42338
Domain:
  • The inhibitory interactions with PIK3R1 are mediated by the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1; the C2 PI3K-type domain, the PI3K helical domain, and the PI3K/PI4K kinase domain with the nSH2 (N-terminal SH2) region of PIK3R1; and the PI3K/PI4K kinase domain with the cSH2 (C-terminal SH2) region of PIK3R1. The inhibitory interaction between the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1 is weak. The nuclear localization signal (NLS) is required for its function in cell survival
  • Contains 1 C2 PI3K-type domain.
  • Contains 1 PI3K-ABD domain.
  • Contains 1 PI3K-RBD domain.
  • Contains 1 PI3K/PI4K domain.
  • Contains 1 PIK helical domain.
Family:
  • Belongs to the PI3/PI4-kinase family.
genes like me logo Genes that share domains with PIK3CB: view

Function for PIK3CB Gene

Molecular function for PIK3CB Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
UniProtKB/Swiss-Prot Function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors.

Enzyme Numbers (IUBMB) for PIK3CB Gene

Gene Ontology (GO) - Molecular Function for PIK3CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 19380743
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity --
GO:0016303 1-phosphatidylinositol-3-kinase activity IBA --
genes like me logo Genes that share ontologies with PIK3CB: view
genes like me logo Genes that share phenotypes with PIK3CB: view

Animal Models for PIK3CB Gene

MGI Knock Outs for PIK3CB:

miRNA for PIK3CB Gene

miRTarBase miRNAs that target PIK3CB

No data available for Transcription Factor Targeting and HOMER Transcription for PIK3CB Gene

Localization for PIK3CB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIK3CB Gene

Cytoplasm. Nucleus. Note=Interaction with PIK3R2 is required for nuclear localization and export.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIK3CB Gene COMPARTMENTS Subcellular localization image for PIK3CB gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 3
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PIK3CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IBA --
GO:0005942 phosphatidylinositol 3-kinase complex IBA --
genes like me logo Genes that share ontologies with PIK3CB: view

Pathways for PIK3CB Gene

SuperPathways for PIK3CB Gene

Superpath Contained pathways
1 PI-3K cascade
2 Signaling by FGFR
3 Translation Insulin regulation of translation
4 IL-9 Signaling Pathways
5 Insulin receptor signalling cascade
genes like me logo Genes that share pathways with PIK3CB: view

UniProtKB/Swiss-Prot P42338-PK3CB_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis

Gene Ontology (GO) - Biological Process for PIK3CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS 10570282
GO:0001952 regulation of cell-matrix adhesion IMP 25139353
GO:0006644 phospholipid metabolic process TAS --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0006874 cellular calcium ion homeostasis IEA --
genes like me logo Genes that share ontologies with PIK3CB: view

Compounds for PIK3CB Gene

(5) Tocris Compounds for PIK3CB Gene

Compound Action Cas Number
740 Y-P Cell-permeable PI 3-kinase activator [1236188-16-1]
PF 05212384 Potent and selective dual PI 3-K/mTOR inhibitor [1197160-78-3]
PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK [371935-79-4]
PI 828 PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130) [942289-87-4]
Quercetin Non-selective PI 3-kinase inhibitor [117-39-5]

(382) HMDB Compounds for PIK3CB Gene

Compound Synonyms Cas Number PubMed IDs
1-Phosphatidyl-D-myo-inositol
  • 1-Phosphatidyl-1D-myo-inositol
Not Available
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Phosphatidylinositol-3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
Not Available
PI(16:0/16:0)
  • Phosphatidylinositol(32:0)
Not Available

(38) Novoseek inferred chemical compound relationships for PIK3CB Gene

Compound -log(P) Hits PubMed IDs
phosphoinositide 88.2 62
phosphatidylinositol 87.2 101
wortmannin 81.9 43
phosphatidylinositol-3,4,5-trisphosphate 76.1 5
rapamycin 64 18
genes like me logo Genes that share compounds with PIK3CB: view

Transcripts for PIK3CB Gene

Unigene Clusters for PIK3CB Gene

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIK3CB Gene

No ASD Table

Relevant External Links for PIK3CB Gene

GeneLoc Exon Structure for
PIK3CB
ECgene alternative splicing isoforms for
PIK3CB

Expression for PIK3CB Gene

mRNA expression in normal human tissues for PIK3CB Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIK3CB Gene

SOURCE GeneReport for Unigene cluster for PIK3CB Gene Hs.239818

mRNA Expression by UniProt/SwissProt for PIK3CB Gene

P42338-PK3CB_HUMAN
Tissue specificity: Expressed ubiquitously
genes like me logo Genes that share expressions with PIK3CB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PIK3CB Gene

Orthologs for PIK3CB Gene

This gene was present in the common ancestor of animals.

Orthologs for PIK3CB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIK3CB 35
  • 99.81 (n)
  • 100 (a)
PIK3CB 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PIK3CB 35
  • 93.18 (n)
  • 96.64 (a)
PIK3CB 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIK3CB 35
  • 93.96 (n)
  • 97.29 (a)
PIK3CB 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pik3cb 35
  • 88.44 (n)
  • 95.86 (a)
Pik3cb 16
Pik3cb 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIK3CB 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIK3CB 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pik3cb 35
  • 88.69 (n)
  • 95.89 (a)
chicken
(Gallus gallus)
Aves PIK3CB 35
  • 80.2 (n)
  • 87.12 (a)
PIK3CB 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIK3CB 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pik3cb 35
  • 71.98 (n)
  • 78.25 (a)
zebrafish
(Danio rerio)
Actinopterygii pik3cb 35
  • 66.82 (n)
  • 69.03 (a)
pik3cb 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pi3K92E 36
  • 37 (a)
OneToMany
Pi3K92E 37
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for PIK3CB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PIK3CB Gene

ENSEMBL:
Gene Tree for PIK3CB (if available)
TreeFam:
Gene Tree for PIK3CB (if available)

Paralogs for PIK3CB Gene

Paralogs for PIK3CB Gene

genes like me logo Genes that share paralogs with PIK3CB: view

Variants for PIK3CB Gene

Sequence variations from dbSNP and Humsavar for PIK3CB Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs168633 -- 138,776,917(+) gactc(C/T)acctc intron-variant
rs181729 -- 138,708,293(+) AGGGT(C/T)TCTGT upstream-variant-2KB, intron-variant
rs187244 -- 138,685,378(-) actct(C/T)ttacc intron-variant
rs187245 -- 138,696,230(+) cagcc(A/T)ggagt intron-variant
rs187246 -- 138,662,274(+) acccc(A/G)caaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIK3CB Gene

Variant ID Type Subtype PubMed ID
nsv428422 CNV Gain+Loss 18775914
esv271132 CNV Insertion 20981092
esv269442 CNV Insertion 20981092
esv2571713 CNV Deletion 19546169

Relevant External Links for PIK3CB Gene

HapMap Linkage Disequilibrium report
PIK3CB
Human Gene Mutation Database (HGMD)
PIK3CB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIK3CB Gene

Disorders for PIK3CB Gene

(20) Novoseek inferred disease relationships for PIK3CB Gene

Disease -log(P) Hits PubMed IDs
cancer 37.8 25
colon cancer 23.2 4
tumors 22.4 15
metastasis 4.1 2
leukemia 0 1

Relevant External Links for PIK3CB

Genetic Association Database (GAD)
PIK3CB
Human Genome Epidemiology (HuGE) Navigator
PIK3CB
genes like me logo Genes that share disorders with PIK3CB: view

No data available for UniProtKB/Swiss-Prot for PIK3CB Gene

Publications for PIK3CB Gene

  1. Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase: cloning, genomic structure, and screening for variants in patients with type 2 diabetes. (PMID: 11016459) Kossila M. … Laakso M. (Diabetes 2000) 4 23 48
  2. Mutation analysis of PIK3CA and PIK3CB in esophageal cancer and Barrett's esophagus. (PMID: 16380997) Phillips W.A. … Campbell I.G. (Int. J. Cancer 2006) 3 23 48
  3. PTEN-deficient cancers depend on PIK3CB. (PMID: 18755892) Wee S. … Lengauer C. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 23
  4. Impact of rs361072 in the phosphoinositide 3-kinase p110beta gene on whole-body glucose metabolism and subunit protein expression in skeletal muscle. (PMID: 20107106) Ribel-Madsen R. … Vaag A. (Diabetes 2010) 3 23 48
  5. Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85. (PMID: 8246984) Hu P. … Schlessinger J. (Mol. Cell. Biol. 1993) 2 3 4

Products for PIK3CB Gene

Sources for PIK3CB Gene

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