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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PIK3CB Gene

protein-coding GIFtS: 69
GCID: GC03M138372

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic...

(Previous names: phosphoinositide-3-kinase, catalytic, beta polypeptide...)
(Previous symbol: PIK3C1)

Explore 63 diseases affiliated with
PIK3CB via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic Subunit Beta¹ ²		PI3K²
PIK3C1¹ ² ³		PI3KBETA²
Phosphoinositide-3-Kinase, Catalytic, Beta Polypeptide¹ ²		Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform²
Phosphatidylinositol 4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit Beta² ³		Phosphatidylinositol-4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit Beta²
PtdIns-3-Kinase Subunit Beta² ³		PI3-Kinase P110 Subunit Beta²
PtdIns-3-Kinase Subunit P110-Beta² ³		PtdIns-3-Kinase P110²
PI3K-Beta¹		PI3Kbeta³
PI3-Kinase Subunit Beta² ³		P110beta¹
EC 2.7.1.153³ ⁸		PI3KCB⁵
P110BETA²		EC 2.7.1⁸

External Ids:	HGNC: 8976¹	Entrez Gene: 5291²	Ensembl: ENSG00000051382⁷	OMIM: 602925⁵	UniProtKB: P42338³

Export aliases for PIK3CB gene to outside databases

Previous GC identifers: GC03M135330 GC03M139174 GC03M139654 GC03M139693 GC03M139855 GC03M135748

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PIK3CB:

This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important

in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic

subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the

activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative

splicing results in multiple transcript variants. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: PK3CB_HUMAN, P42338

Function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P

(Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate

phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to

the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival,

proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled

receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream

receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation.

Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM

(immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of

ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet

aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell

migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P

(Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its

lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in

which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell

proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid

kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven

tumors

summary for PIK3CB:

PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the

3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of

cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell

migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric

consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and

delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst

p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have

recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes

(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI

3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to

play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3CB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PIK3CB gene promoter:
ER-alpha POU3F1 FOXO3 Tal-1beta FOXO3b E47 PPAR-alpha Hand1 FOXO3a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PIK3CB promoter sequence

Search SABiosciences Chromatin IP Primers for PIK3CB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIK3CB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.3 Ensembl cytogenetic band: 3q22.3 HGNC cytogenetic band: 3q21-qter

PIK3CB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIK3CB gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M138372: view genomic region (about GC identifiers)

Start:	138,372,860 bp from pter	End:	138,553,780 bp from pter
Size:	180,921 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PK3CB_HUMAN, P42338 (See protein sequence)

Recommended Name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

Size: 1070 amino acids; 122762 Da

Subunit: Heterodimer of a catalytic subunit PIK3CB and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interaction

with PIK3R2 is required for nuclear localization and nuclear export. Part of a complex with PIK3R1 and PTEN. Binding

to PTEN may antagonize the lipid kinase activity under normal growth conditions. Part of a complex involved in

autophagosome formation composed of PIK3C3 and PIK3R4 (By similarity). Interacts with BECN1, ATG14 and RAB5A (By

similarity)

Subcellular location: Cytoplasm. Nucleus. Note=Interaction with PIK3R2 is required for nuclear localization and export

Secondary accessions: D3DNF0 Q24JU2

Explore the universe of human proteins at neXtProt for PIK3CB: NX_P42338

Post-translational modifications:

Phosphorylation at Ser-1070 down-regulates lipid kinase activity¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P42338

4/13 DME Specific Peptides for PIK3CB (P42338) (see all 13)

SCAGYCV

DLRQDML

LFHIDFG

VDFLLPTG

PIK3CB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001242974.1 NP_006210.1

ENSEMBL proteins:

ENSP00000418143 ENSP00000419513 ENSP00000420108 ENSP00000417869 ENSP00000419091

ENSP00000418834 ENSP00000419857 ENSP00000420399 ENSP00000417329 ENSP00000289153

ENSP00000438259

Reactome Protein details: P42338
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant PIK3CB Protein
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: PIK3CB OriGene Custom Protein Services for PIK3CB
	GenScript Custom Purified and Recombinant Proteins Services for PIK3CB
	Novus Biologicals PIK3CB Proteins Novus Biologicals PIK3CB Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for PIK3CB
	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005829	cytosol	TAS	--
GO:0005942	phosphatidylinositol 3-kinase complex	--	--
GO:0031526	brush border membrane	--	--

PIK3CB for ontologies About GeneDecksing

PIK3CB Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PIK3CB
	R&D Systems Antibodies for PIK3CB (PI 3-Kinase p110 beta)
	Cell Signaling Technology (CST) Antibodies for PIK3CB
	OriGene Antibodies (see all 2): PIK3CB OriGene Custom Antibody Services for PIK3CB
	GenScript Custom Superior Antibodies Services for PIK3CB
	Novus Biologicals PIK3CB Antibodies
	Abcam antibodies for PIK3CB
	Browse Antibodies at Uscn
	ThermoFisher Antibody for PIK3CB

Assay Products for PIK3CB:

	EMD Millipore Kits and Assays for the Analysis of PIK3CB
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PIK3CB
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PIK3CB for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR001263 PInositide-3_kin_accessory_dom

IPR003113 PI3K_adapt-bd_dom

IPR002420 PI3K_C2_dom

IPR011009 Kinase-like_dom

IPR000403 PI3/4_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry P42338

ProtoNet protein and cluster: P42338

3 Blocks protein families:

IPB000341 Phosphoinositide 3-kinase

IPB000403 Phosphatidylinositol 3- and 4-kinase

IPB003113 Phosphatidylinositol 3-kinase

UniProtKB/Swiss-Prot: PK3CB_HUMAN, P42338

Domain: The inhibitory interactions with PIK3R1 are mediated by the PI3K-ABD domain and the C2 PI3K-type domain with

the iSH2 (inter-SH2) region of PIK3R1; the C2 PI3K-type domain, the PI3K helical domain, and the PI3K/PI4K kinase

domain with the nSH2 (N-terminal SH2) region of PIK3R1; and the PI3K/PI4K kinase domain with the cSH2 (C-terminal SH2)

region of PIK3R1. The inhibitory interaction between the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2

(inter-SH2) region of PIK3R1 is weak. The nuclear localization signal (NLS) is required for its function in cell

survival

Similarity: Belongs to the PI3/PI4-kinase family

Similarity: Contains 1 C2 PI3K-type domain

Similarity: Contains 1 PI3K-ABD domain

Similarity: Contains 1 PI3K-RBD domain

Similarity: Contains 1 PI3K/PI4K domain

Similarity: Contains 1 PIK helical domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary: