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PIK3CA Gene

protein-coding   GIFtS: 73
GCID: GC03P178865

Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic...

(Previous names: phosphoinositide-3-kinase, catalytic, alpha polypeptide)
  See PIK3CA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic Subunit
Alpha1 2
     Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha
Isoform2
Phosphoinositide-3-Kinase, Catalytic, Alpha Polypeptide1 2     Phosphatidylinositol-4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit
Alpha2
PtdIns-3-Kinase Subunit P110-Alpha2 3     Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit, Alpha
Isoform2
Serine/Threonine Protein Kinase PIK3CA2 3     PI3-Kinase P110 Subunit Alpha2
PI3K-alpha2 3     EC 2.7.1.1533
CLOVE2 5     EC 2.7.11.13
CWS52 5     PI3Kalpha3
MCAP2 5     p110alpha3
MCM2 5     Phosphatidylinositol 4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit
Alpha3
MCMTC2 5     Phosphoinositide-3-Kinase Catalytic Alpha Polypeptide3
PI3K2     PI3-Kinase Subunit Alpha3
p110-alpha2     PtdIns-3-Kinase Subunit Alpha3
Phosphatidylinositol 3-Kinase, Catalytic, 110-KD, Alpha2     EC 2.7.18
Phosphatidylinositol 3-Kinase, Catalytic, Alpha Polypeptide2     

External Ids:    HGNC: 89751   Entrez Gene: 52902   Ensembl: ENSG000001218797   OMIM: 1718345   UniProtKB: P423363   

Export aliases for PIK3CA gene to outside databases

Previous GC identifers: GC03P175570 GC03P179758 GC03P180318 GC03P180237 GC03P180399 GC03P180349 GC03P176269


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PIK3CA Gene:
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The
protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P
and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.
(provided by RefSeq, Jul 2008)

GeneCards Summary for PIK3CA Gene:
PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha) is a protein-coding gene. Diseases associated with PIK3CA include macrodactyly of fingers, unilateral, and cowden syndrome 5. GO annotations related to this gene include protein kinase activator activity and protein serine/threonine kinase activity. An important paralog of this gene is PIK3C2B.

UniProtKB/Swiss-Prot: PK3CA_HUMAN, P42336
Function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P
(Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate
phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing
proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth,
survival, proliferation, motility and morphology. Participates in cellular signaling in response to various
growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as
EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins.
Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by
regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by
activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation in breast cancer cells through the
PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates
in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Has also serine-protein
kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS

summary for PIK3CA Gene:
PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the
3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of
cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell
migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric
consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and
delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst
p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have
recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes
(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI
3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to
play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3CA (P110α) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PIK3CA gene promoter:
         PPAR-gamma1   FOXO4   FOXO1a   CUTL1   PPAR-gamma2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIK3CA promoter sequence
   Search Chromatin IP Primers for PIK3CA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIK3CA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.3   Ensembl cytogenetic band:  3q26.32   HGNC cytogenetic band: 3q26.3

PIK3CA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIK3CA gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P178865:  view genomic region     (about GC identifiers)

Start:
178,865,902 bp from pter      End:
178,957,881 bp from pter
Size:
91,980 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PK3CA_HUMAN, P42336 (See protein sequence)
Recommended Name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform  
Size: 1068 amino acids; 124284 Da
Subunit: Heterodimer of a catalytic subunit PIK3CA and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3).
Interacts with IRS1 in nuclear extracts. Interacts with RUFY3 (By similarity). Interacts with RASD2 (By
similarity). Interacts with APPL1. Interacts with HRAS and KRAS (By similarity). Interaction with HRAS/KRAS is
required for PI3K pathway signaling and cell proliferation stimulated by EGF and FGF2 (By similarity)
Miscellaneous: The avian sarcoma virus 16 genome encodes an oncogene derived from PIK3CA (PubMed:18418043)
Selected PDB 3D structures from and Proteopedia for PIK3CA (see all 8):
2ENQ (3D)        2RD0 (3D)        3HHM (3D)        3HIZ (3D)        3ZIM (3D)        4L1B (3D)    
Secondary accessions: Q14CW1 Q99762

Explore the universe of human proteins at neXtProt for PIK3CA: NX_P42336

Explore proteomics data for PIK3CA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys100
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PIK3CA (P42336) (see all 7)
     SCAGYCV  DLRQDML  LFHIDFG  LTDILKQ 


    See PIK3CA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006209.2  
    ENSEMBL proteins: 
     ENSP00000418145   ENSP00000263967   ENSP00000417479  
    Reactome Protein details: P42336

    PIK3CA Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PIK3CA Protein
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    Novus Biologicals PIK3CA Protein
    Novus Biologicals PIK3CA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PIK3CA 

     
    antibodies-online proteins for PIK3CA (3 products) 

     
    antibodies-online peptides for PIK3CA

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    antibodies-online antibodies for PIK3CA (96 products) 

    PIK3CA Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for PIK3CA 
    antibodies-online kits for PIK3CA (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
    Phosphatidylinositol-4,5-bisphosphate 3-kinase family

    Selected InterPro protein domains (see all 10):
     IPR001263 PInositide-3_kin_accessory_dom
     IPR003113 PI3K_adapt-bd_dom
     IPR002420 PI3K_C2_dom
     IPR011009 Kinase-like_dom
     IPR000403 PI3/4_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P42336

    ProtoNet protein and cluster: P42336

    4 Blocks protein domains:
    IPB000008 C2 domain
    IPB000341 Phosphoinositide 3-kinase
    IPB000403 Phosphatidylinositol 3- and 4-kinase
    IPB003113 Phosphatidylinositol 3-kinase


    UniProtKB/Swiss-Prot: PK3CA_HUMAN, P42336
    Domain: The PI3K-ABD domain and the PI3K-RBD domain interact with the PI3K/PI4K kinase domain. The C2 PI3K-type
    domain may facilitate the recruitment to the plasma membrane. The inhibitory interactions with PIK3R1 are
    mediated by the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1, and the
    C2 PI3K-type domain, the PI3K helical domain, and the PI3K/PI4K kinase domain with the nSH2 (N-terminal SH2)
    region of PIK3R1
    Similarity: Belongs to the PI3/PI4-kinase family
    Similarity: Contains 1 C2 PI3K-type domain
    Similarity: Contains 1 PI3K-ABD domain
    Similarity: Contains 1 PI3K-RBD domain
    Similarity: Contains 1 PI3K/PI4K domain
    Similarity: Contains 1 PIK helical domain


    Find genes that share domains with PIK3CA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PK3CA_HUMAN, P42336
    Function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P
    (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate
    phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing
    proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth,
    survival, proliferation, motility and morphology. Participates in cellular signaling in response to various
    growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as
    EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins.
    Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by
    regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by
    activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation in breast cancer cells through the
    PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates
    in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Has also serine-protein
    kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS
    Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol
    3,4,5-trisphosphate
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for PIK3CA:
    phosphatidylinositol-3-kinase,catalytic,class 1,alpha subunit,widely expressed, activated by growth
    factors,through binding p785 adaptor proteins (PIK3R1,PIK3R2,PIK3R3),activating Akts in the antiapoptotic PIK3
    pathway,antagonized by PTEN,mediating angiogenes is and expression of VEGF in endothelial cells,involved in the
    regulation of cellular processes,potentially oncogenic in ovarian cancer

         Enzyme Numbers (IUBMB): EC 2.7.11.11 EC 2.7.1.1531 EC 2.7.12

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI10490823
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity TAS--
         
    Find genes that share ontologies with PIK3CA           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PIK3CA:
     Increased cell death in HCT116 

         Selected MGI mutant phenotypes (inferred from 11 alleles(MGI details for Pik3ca) (see all 17):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  embryogenesis 
     endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  immune system  integument 
     mortality/aging  muscle  nervous system  no phenotypic analysis  reproductive system 

    Find genes that share phenotypes with PIK3CA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PIK3CA: Pik3catm1Nbm Pik3catm1.1Jjz

       genOway: Develop your customized and physiologically relevant rodent model for PIK3CA

    miRNA
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    miRTarBase miRNAs that target PIK3CA:
    hsa-mir-335-5p (MIRT017306), hsa-mir-148b-3p (MIRT007316), hsa-mir-17-5p (MIRT050839)

    Block miRNA regulation of human, mouse, rat PIK3CA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PIK3CA (see all 13):
    hsa-miR-3910 hsa-miR-203 hsa-miR-1206 hsa-miR-561 hsa-miR-10b hsa-miR-10a hsa-miR-124 hsa-miR-19b
    SwitchGear 3'UTR luciferase reporter plasmidPIK3CA 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PIK3CA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PIK3CA

    Clone
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    GenScript: all cDNA clones in your preferred vector: PIK3CA (NM_006218)
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    Addgene plasmids for PIK3CA 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    plasma membrane3
    cytoskeleton2
    nucleus2
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IBA--
    GO:0005942phosphatidylinositol 3-kinase complex ISS--
    GO:00059431-phosphatidylinositol-4-phosphate 3-kinase, class IA complex IDA--
    GO:0030027lamellipodium IEA--

    Find genes that share ontologies with PIK3CA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PIK3CA About   (see all 166)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Cell adhesion PLAU signaling0.35
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Transcription PPAR Pathway0.34
    Transcription Receptor mediated HIF regulation0.51
    Development Growth hormone signaling via PI3K AKT and MAPK cascades0.34
    Translation Regulation activity of EIF20.47
    mTOR signaling pathway0.34
    2Development HGF signaling pathway
    Development HGF signaling pathway0.45
    Apoptosis and survival Role of CDK5 in neuronal death and survival0.37
    Development Neurotrophin family signaling0.45
    Apoptosis and survival NGF signaling pathway0.36
    Development EGFR signaling via small GTPases0.44
    Neurotrophin signaling pathway0.36
    Development PDGF signaling via MAPK cascades0.41
    Signaling of Hepatocyte Growth Factor Receptor0.35
    3Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    VEGF signaling pathway0.39
    Immune response BCR pathway0.43
    Fc-epsilon receptor I signaling in mast cells0.34
    Fc epsilon RI signaling pathway0.41
    4Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    Immune response IL 4 signaling pathway0.39
    5Prolactin Signaling Pathway
    Development Prolactin receptor signaling0.39
    Prolactin signaling pathway0.33
    Prolactin Signaling Pathway0.39


    Find genes that share SuperPaths with PIK3CA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for PIK3CA
        PI3K / Akt Signaling

    Selected Tocris Bioscience Pathways for PIK3CA (see all 9)
        Akt Pathway
    Insulin Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    Toll-like Receptor Pathway

    Selected GeneGo (Thomson Reuters) Pathways for PIK3CA (see all 68)
        G-protein signaling H-RAS regulation pathway
    Development A2A receptor signaling
    Development CNTF receptor signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway

    Selected BioSystems Pathways for PIK3CA (see all 83)
        MicroRNAs in cardiomyocyte hypertrophy
    Angiogenesis
    Focal Adhesion
    Keap1-Nrf2 Pathway
    EGFR1 Signaling Pathway

    Selected Reactome Pathways for PIK3CA (see all 28)
        Nephrin interactions
    G alpha (12/13) signalling events
    Costimulation by the CD28 family
    Regulation of signaling by CBL
    GAB1 signalosome

    3 PharmGKB Pathways for PIK3CA
        Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Sorafenib Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for PIK3CA) (see all 63):
        Inositol phosphate metabolism
    ErbB signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    Chemokine signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PIK3CA (see all 14): 
              mTOR Signaling in human mouse rat
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              VEGF Signaling in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PIK3CA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PIK3CA (P423361, 2, 3 ENSP000002639674) via UniProtKB, MINT, STRING, and/or I2D (see all 474)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279861, 2, 3, ENSP000002743354EBI-2116585,EBI-79464 MINT-6170530 MINT-7383676 MINT-7298487 I2D: score=9 STRING: ENSP00000274335
    IRS1P355681, 2, 3, ENSP000003048954EBI-2116585,EBI-517592 MINT-68707 I2D: score=2 STRING: ENSP00000304895
    ERBB3P218601, 3, ENSP000002671014EBI-2116585,EBI-720706 I2D: score=1 STRING: ENSP00000267101
    PIK3R3Q925693, ENSP000002627414I2D: score=6 STRING: ENSP00000262741
    GNAQP501483, ENSP000002865484I2D: score=3 STRING: ENSP00000286548
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001944vasculature development TAS19200708
    GO:0006006glucose metabolic process IEA--
    GO:0006468protein phosphorylation ----
    GO:0006644phospholipid metabolic process TAS--

    Find genes that share ontologies with PIK3CA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for PIK3CA
      Browse compounds at ApexBio 

    Compounds for PIK3CA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CZC 24832Selective inhibitor of PI 3-Kinase gamma[1159824-67-5]
    QuercetinNon-selective PI 3-kinase inhibitor[117-39-5]
    PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK [371935-74-9]
    AS 605240Potent and selective PI 3-kinase gamma (PI3Kgamma) inhibitor[648450-29-7]
    740 Y-PCell-permeable PI 3-kinase activator[1236188-16-1]

    Selected HMDB Compounds for PIK3CA (see all 382)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Phosphatidyl-D-myo-inositol1-Phosphatidyl-1D-myo-inositol (see all 6)----
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    PI(16:0/16:0)Phosphatidylinositol(32:0) (see all 8)----
    PI(16:0/16:1(9Z))Phosphatidylinositol(32:1) (see all 14)----
    PI(16:0/16:2(9Z,12Z))Phosphatidylinositol(16:0/16:2n4) (see all 18)----
    PI(16:0/18:0)Phosphatidylinositol(16:0/18:0) (see all 8)----
    PI(16:0/18:1(11Z))Phosphatidylinositol(16:0/18:1w7) (see all 14)----
    PI(16:0/18:1(9Z))Phosphatidylinositol(16:0/18:1) (see all 14)----
    PI(16:0/18:2(9Z,12Z))PIno(16:0/18:2) (see all 14)----

    1 DrugBank Compound for PIK3CA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for PIK3CA gene (see all 86)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 93.1 425 8663584 (4), 12897244 (3), 7713498 (2), 17377809 (2) (see all 99)
    phosphoinositide 89 184 11882383 (2), 10926936 (2), 19679877 (2), 12545728 (2) (see all 99)
    wortmannin 87.1 162 10794659 (3), 11559593 (3), 8657148 (2), 10671571 (2) (see all 99)
    rapamycin 81.3 71 20115955 (2), 18676851 (2), 12433206 (1), 19061482 (1) (see all 55)
    phosphatidylinositol-3,4,5-trisphosphate 74.2 14 12897244 (2), 20054340 (1), 9593670 (1), 19509113 (1) (see all 10)
    naphtho(1,2-b)furan-4,5-dione 71.6 1 20371243 (1), 20036260 (1)
    ly294002 70.2 50 19383818 (3), 18262558 (2), 15277479 (2), 12621049 (2) (see all 28)
    ctmp 64.1 1 16150119 (1)
    tyrosine 60.1 62 10763917 (2), 16311104 (2), 18449193 (2), 10963852 (1) (see all 47)
    glycogen 60.1 22 17055733 (1), 18782353 (1), 20471052 (1), 16170333 (1) (see all 22)

    2 PharmGKB related drug/compound annotations for PIK3CA gene    About this table
    Drug/compound PharmGKB Annotation
    docetaxelCA  
    everolimus



    Find genes that share compounds with PIK3CA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PIK3CA gene: 
    NM_006218.2  

    Unigene Cluster for PIK3CA:

    Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
    Hs.553498  [show with all ESTs]
    Unigene Representative Sequence: AK021510
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477735 ENST00000263967(uc003fjk.3) ENST00000468036 ENST00000462255

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PIK3CA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PIK3CA (see all 13):
    hsa-miR-3910 hsa-miR-203 hsa-miR-1206 hsa-miR-561 hsa-miR-10b hsa-miR-10a hsa-miR-124 hsa-miR-19b
    SwitchGear 3'UTR luciferase reporter plasmidPIK3CA 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PIK3CA
    Predesigned siRNA for gene silencing in human, mouse, rat PIK3CA
    Clone
    Products:
         
    OriGene clones in human, mouse for PIK3CA (see all 7)
    OriGene ORF clones in mouse, rat for PIK3CA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PIK3CA (NM_006218)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIK3CA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3CA
    Addgene plasmids for PIK3CA 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PIK3CA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PIK3CA
      QuantiTect SYBR Green Assays in human, mouse, rat PIK3CA
      QuantiFast Probe-based Assays in human, mouse, rat PIK3CA
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11121) for PIK3CA 

    Additional mRNA sequence: 

    AK021510.1 DQ787424.1 DQ910907.1 

    2 DOTS entries:

    DT.99950166  DT.313816 

    Selected AceView cDNA sequences (see all 74):

    BX108528 AA732379 AA905413 AA331546 AL706270 BG497751 BX437220 BP337031 
    N33289 AI679006 AU134684 CB267213 AU129890 AA661803 AI245465 CA310666 
    BQ228953 U79143 AW951459 BX484734 BE246374 BX473473 BM470620 BE279196 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PIK3CA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGATTTCA
    PIK3CA Expression
    About this image


    PIK3CA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PIK3CA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIK3CA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553498
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PIK3CA (see all 14): 
              mTOR Signaling in human mouse rat
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              VEGF Signaling in human mouse rat
              Cell Motility in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PIK3CA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PIK3CA
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    QuantiFast Probe-based Assays in human, mouse, rat PIK3CA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3CA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PIK3CA gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pik3ca1 , 5 phosphatidylinositol 3-kinase, catalytic, alpha polypeptide1, 5 89.64(n)1
    98.69(a)1
      3 (15.70 cM)5
    187061  NM_008839.21  NP_032865.21 
     323976715 
    chicken
    (Gallus gallus)
    Aves PIK3CA1 phosphoinositide-3-kinase, catalytic, alpha polypeptide 85.3(n)
    96.25(a)
      424971  NM_001004410.1  NP_001004410.1 
    lizard
    (Anolis carolinensis)
    Reptilia PIK3CA6
    phosphatidylinositol-4,5-bisphosphate 3-kinase, ca...
    95(a)
    1 ↔ 1
    3(2307494-2331193)
    African clawed frog
    (Xenopus laevis)
    Amphibia pik3ca-A2 phosphoinositide-3-kinase, catalytic, alpha subunit 79.45(n)    AF204924.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5617371 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic more 76.25(n)
    91.76(a)
      561737  XM_685143.5  XP_690235.2 
    worm
    (Caenorhabditis elegans)
    Secernentea age-11 age-1 47.81(n)
    34.13(a)
      174762  NM_064061.4  NP_496462.2 


    ENSEMBL Gene Tree for PIK3CA (if available)
    TreeFam Gene Tree for PIK3CA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PIK3CA gene
    PIK3C2B2  PIK3CD2  PIK3C2G2  PIK3CG2  PIK3C32  PIK3CB2  PIK3C2A2  
    5 SIMAP similar genes for PIK3CA using alignment to 4 protein entries:     PK3CA_HUMAN (see all proteins):
    PIK3CA variant protein    DKFZp779K1237    PIK3CB    PIK3CD    PIK3CG

    Find genes that share paralogs with PIK3CA           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PIK3CA
    PGOHUM00000246382


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PIK3CA (see all 1826)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0692524
    Megalencephaly-capillary malformation-polymicrogyria syndrome (MCAP)4--see VAR_0692522 G R mis40--------
    VAR_0261694
    Cancer4--see VAR_0261692 Y C mis40--------
    VAR_0692584
    Megalencephaly-capillary malformation-polymicrogyria syndrome (MCAP)4--see VAR_0692582 T A mis40--------
    VAR_0261964
    Cancer4--see VAR_0261962 H L mis40--------
    VAR_0261904
    Megalencephaly-capillary malformation-polymicrogyria syndrome (MCAP)4--see VAR_0261902 M I mis40--------
    VAR_0261804
    Cancer4--see VAR_0261802 Q K mis40--------
    VAR_0692564
    Megalencephaly-capillary malformation-polymicrogyria syndrome (MCAP)4--see VAR_0692562 E K mis40--------
    VAR_0261844
    Megalencephaly-capillary malformation-polymicrogyria syndrome (MCAP)4--see VAR_0261842 Y C mis40--------
    VAR_0261954
    Cancer4--see VAR_0261952 T K mis40--------
    VAR_0261724
    Cancer4--see VAR_0261722 E Q mis40--------

    HapMap Linkage Disequilibrium report for PIK3CA (178865902 - 178957881 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PIK3CA (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659099CNV Deletion23128226
    esv2726256CNV Deletion23290073
    esv1007496CNV Loss20482838
    nsv524471CNV Loss19592680
    nsv822351CNV Loss20364138
    nsv878037CNV Loss21882294
    dgv5352n71CNV Loss21882294
    nsv461026CNV Gain19166990
    nsv829806CNV Gain17160897
    nsv819800CNV Gain19587683

    Human Gene Mutation Database (HGMD): PIK3CA
    Selected Site Specific Mutation Identification with PCR Assays for PIK3CA (see all 63):
    Cosmic IdAA Change
    12458p.E545A
    17443p.G1007R
    12590p.T1025S
    12580p.K111N
    771p.T1025A
    Selected Site Specific Cancer Mutation PCR Panels containing PIK3CA (see all 31):
    Breast Cancer
    Receptor Tyrosine Kinase (RTK) (Panel II)
    Cancer Comprehensive Panel 384HT
    Lung Cancer
    3 Copy Number PCR Panels containing PIK3CA:
    Oncogenes & Tumor Suppressor Genes 384HC
    Lung Cancer
    Kinases & Phosphatases
    SeqTarget long-range PCR primers for resequencing PIK3CA
    DNA2.0 Custom Variant and Variant Library Synthesis for PIK3CA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 171834   
    OMIM disorders: 167000  114480  114500  613659  114550  211980  182000  162900  612918  602501  603387  615108  
    UniProtKB/Swiss-Prot: PK3CA_HUMAN, P42336
  • Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from
    the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with
    progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon
    and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The gene
    represented in this entry may be involved in disease pathogenesis
  • Breast cancer (BC) [MIM:114480]: A common malignancy originating from breast epithelial tissue. Breast
    neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common
    type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated
    by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different
    families or even in the same case. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry
  • Ovarian cancer (OC) [MIM:167000]: The term ovarian cancer defines malignancies originating from ovarian
    tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the
    most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of
    late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry
  • Hepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The
    major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV)
    infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. Note=The
    gene represented in this entry may be involved in disease pathogenesis
  • Note=Most of the cancer-derived mutations are missense mutations and map to one of the three hotspots:
    Glu-542; Glu-545 and His-1047. Mutated isoforms participate in cellular transformation and tumorigenesis induced
    by oncogenic receptor tyrosine kinases (RTKs) and HRAS/KRAS. Interaction with HRAS/KRAS is required for
    Ras-driven tumor formation. Mutations increasing the lipid kinase activity are required for oncogenic signaling.
    The protein kinase activity may not be required for tumorigenesis
  • Keratosis, seborrheic (KERSEB) [MIM:182000]: A common benign skin tumor. Seborrheic keratoses usually
    begin with the appearance of one or more sharply defined, light brown, flat macules. The lesions may be sparse or
    numerous. As they initially grow, they develop a velvety to finely verrucous surface, followed by an uneven warty
    surface with multiple plugged follicles and a dull or lackluster appearance. Note=The disease is caused by
    mutations affecting the gene represented in this entry
  • Megalencephaly-capillary malformation-polymicrogyria syndrome (MCAP) [MIM:602501]: A syndrome
    characterized by a spectrum of anomalies including primary megalencephaly, prenatal overgrowth, brain and body
    asymmetry, cutaneous vascular malformations, digital anomalies consisting of syndactyly with or without postaxial
    polydactyly, connective tissue dysplasia involving the skin, subcutaneous tissue, and joints, and cortical brain
    malformations, most distinctively polymicrogyria. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome (MPPH) [MIM:603387]: A syndrome
    characterized by megalencephaly, hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is
    considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE) [MIM:612918]: A
    sporadically occurring, non-hereditary disorder characterized by asymmetric somatic hypertrophy and anomalies in
    multiple organs. It is defined by four main clinical findings: congenital lipomatous overgrowth, vascular
    malformations, epidermal nevi, and skeletal/spinal abnormalities. The presence of truncal overgrowth and
    characteristic patterned macrodactyly at birth differentiates CLOVE from other syndromic forms of overgrowth.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Cowden syndrome 5 (CWS5) [MIM:615108]: A form of Cowden syndrome, a hamartomatous polyposis syndrome with
    age-related penetrance. Cowden syndrome is characterized by hamartomatous lesions affecting derivatives of
    ectodermal, mesodermal and endodermal layers, macrocephaly, facial trichilemmomas (benign tumors of the hair
    follicle infundibulum), acral keratoses, papillomatous papules, and elevated risk for development of several
    types of malignancy, particularly breast carcinoma in women and thyroid carcinoma in both men and women. Colon
    cancer and renal cell carcinoma have also been reported. Hamartomas can be found in virtually every organ, but
    most commonly in the skin, gastrointestinal tract, breast and thyroid. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • Selected diseases for PIK3CA (see all 40):    
    About MalaCards
    macrodactyly of fingers, unilateral    cowden syndrome 5    clove syndrome, somatic    megalencephaly-capillary malformation-polymicrogyria syndrome, somatic
    macrodactyly of toes, unilateral    segmental progressive overgrowth syndrome with fibroadipose hyperplasia    megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome, somatic    cloves syndrome
    ethmoid sinus adenocarcinoma    hemihyperplasia-multiple lipomatosis syndrome    pik3ca-related segmental overgrowth    keratosis, seborrheic, somatic
    dermatosis papulosa nigra    hemimegalencephaly    nonsmall cell lung cancer, somatic    epidermal nevus, somatic
    acute urate nephropathy    megalencephaly    urinary tract obstruction    breast cancer, somatic

    6 diseases from the University of Copenhagen DISEASES database for PIK3CA:
    Colorectal cancer     Carcinoma     Breast cancer     Endometrial cancer
    Ovarian cancer     Lung cancer

    Find genes that share disorders with PIK3CA           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PIK3CA gene (see all 80)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 68.6 291 19573809 (6), 19384426 (5), 18059185 (4), 17575152 (4) (see all 99)
    somatic mutations 68.1 59 16168105 (4), 17052259 (3), 16533766 (2), 18951408 (2) (see all 33)
    tumors 65.5 343 17714348 (7), 15928251 (6), 19237633 (5), 16322209 (4) (see all 99)
    glioblastoma 65.2 58 17235514 (5), 18676851 (5), 17050665 (4), 12782577 (4) (see all 22)
    follicular thyroid cancer 61.6 4 15928251 (2), 17426084 (1)
    thyroid carcinoma anaplastic 60.9 5 16288007 (2), 15928251 (1), 18000091 (1), 18502332 (1)
    breast cancer 56.5 135 16168105 (7), 19685490 (5), 17202311 (5), 18676830 (4) (see all 57)
    cowden disease 55.9 1 19897009 (1)
    glioblastoma multiforme 51.8 4 17050665 (1), 15924253 (1), 15143086 (1)
    ovarian cancer 51.7 46 12874030 (4), 16839745 (3), 15028555 (3), 18270270 (3) (see all 23)

    Genetic Association Database (GAD): PIK3CA
    Human Genome Epidemiology (HuGE) Navigator: PIK3CA (129 documents)

    Export disorders for PIK3CA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIK3CA gene, integrated from 10 sources (see all 1552):
    (articles sorted by number of sources associating them with PIK3CA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PIK3CA mutation and histological type in breast carcinoma: high frequency of mutations in lobular carcinoma. (PubMed id 16353168)1, 2, 4 Buttitta F....Marchetti A. (J. Pathol. 2006)
    2. The prevalence of PIK3CA mutations in gastric and colon cancer. (PubMed id 15994075)1, 2, 4 Velho S....Seruca R. (Eur. J. Cancer 2005)
    3. Mutations of PIK3CA in gastric adenocarcinoma. (PubMed id 15784156)1, 2, 9 Li V.S.W.... Leung S.Y. (BMC Cancer 2005)
    4. Molecular analysis of PIK3CA, BRAF, and RAS oncogenes in periampullary and ampullary adenomas and carcinomas. (PubMed id 19440799)1, 4, 9 SchAPnleben F....Su G.H. (J. Gastrointest. Surg. 2009)
    5. Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer. (PubMed id 19789368)1, 4, 9 Kure S....Ogino S. (amp 2009)
    6. Clinicopathological analysis of papillary thyroid cancer with PIK3CA alterations in a Middle Eastern population. (PubMed id 18000091)1, 4, 9 Abubaker J....Al-Kuraya K.S. (J. Clin. Endocrinol. Metab. 2008)
    7. PIK3CA mutation is predictive of poor survival in patients with colorectal cancer. (PubMed id 17590872)1, 4, 9 Kato S....Sugihara K. (Int. J. Cancer 2007)
    8. Somatic mutation and gain of copy number of PIK3CA in human breast cancer. (PubMed id 16168105)1, 4, 9 Wu G....Sidransky D. (Breast Cancer Res. 2005)
    9. High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma. (PubMed id 16322209)1, 2, 9 Oda K.... McCormick F. (Cancer Res. 2005)
    10. PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer. (PubMed id 19237633)1, 4, 9 Ogino S....Fuchs C.S. (J. Clin. Oncol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5290 HGNC: 8975 AceView: PIK3CA Ensembl:ENSG00000121879 euGenes: HUgn5290
    ECgene: PIK3CA Kegg: 5290 H-InvDB: PIK3CA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PIK3CA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PIK3CA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PIK3CA gene:
    Search GeneIP for patents involving PIK3CA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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