PIK3CA Gene
protein-coding GIFtS: 70
GCID: GC03P178865
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phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic...(Previous names: phosphoinositide-3-kinase, catalytic, alpha polypeptide...)
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Aliases
for PIK3CA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic Subunit Alpha1 2 | | Phosphatidylinositol 3-Kinase, Catalytic, Alpha Polypeptide2 | | PI3K1 2 | | Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform2 | | Phosphoinositide-3-Kinase, Catalytic, Alpha Polypeptide1 2 | | Phosphatidylinositol-4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit Alpha2 | | Phosphatidylinositol 4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit Alpha2 3 | | Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit, Alpha Isoform2 | | PtdIns-3-Kinase Subunit P110-Alpha2 3 | | PI3-Kinase P110 Subunit Alpha2 | | Serine/Threonine Protein Kinase PIK3CA2 3 | | EC 2.7.1.1533 | | PI3K-Alpha1 | | EC 2.7.11.13 | | CLOVE2 | | PI3Kalpha3 | | MCAP2 | | P110alpha1 | | MCM2 | | Phosphoinositide-3-Kinase Catalytic Alpha Polypeptide3 | | MCMTC2 | | PI3-Kinase Subunit Alpha3 | | P110-Alpha1 | | PtdIns-3-Kinase Subunit Alpha3 | | Phosphatidylinositol 3-Kinase, Catalytic, 110-KD, Alpha2 | | EC 2.7.18 |
Export aliases for PIK3CA gene to outside databasesPrevious GC identifers: GC03P175570 GC03P179758 GC03P180318 GC03P180237 GC03P180399 GC03P180349 GC03P176269 |
Summaries
for PIK3CA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PIK3CA:
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The proteinencoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P andPtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PK3CA_HUMAN, P42336Function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P(Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generatephosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins tothe membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival,proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors.Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1,VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cellmigration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required forlymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF.Regulates invadopodia formation in breast cancer cells through the PDPK1-AKT1 pathway. Participates incardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stemcells through PDK1 and protein kinase C pathway. Has also serine-protein kinase activity: phosphorylates PIK3R1(p85alpha regulatory subunit), EIF4EBP1 and HRAS
 summary
for PIK3CA: PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the
3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of
cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell
migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric
consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and
delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst
p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have
recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes
(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI
3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to
play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.
Gene Wiki entry for PIK3CA (P110α)
|
Genomic Views
for PIK3CA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PIK3CA gene promoter:
PPAR-gamma1 FOXO4 FOXO1a CUTL1 PPAR-gamma2 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PIK3CA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIK3CA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q26.3 Ensembl cytogenetic band: 3q26.32 HGNC cytogenetic band: 3q26.3PIK3CA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P178865: view genomic region
(about GC identifiers)
Start:
|
178,865,902 bp from pter |
End:
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178,957,881 bp from pter |
Size:
|
91,980 bases |
Orientation:
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plus strand |
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Proteins
for PIK3CA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PK3CA_HUMAN, P42336 (See
protein sequence)Recommended Name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Size: 1068 amino acids; 124284 Da
Subunit: Heterodimer of a catalytic subunit PIK3CA and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interactswith IRS1 in nuclear extracts. Interacts with RUFY3 (By similarity). Interacts with RASD2 (By similarity). Interactswith APPL1. Interacts with HRAS1 and KRAS (By similarity). Interaction with HRAS1/KRAS is required for PI3K pathwaysignaling and cell proliferation stimulated by EGF and FGF2 (By similarity)
Miscellaneous: The avian sarcoma virus 16 genome encodes an oncogene derived from PIK3CA (PubMed:18418043)
5 PDB 3D structures from  and Proteopedia  for PIK3CA:2ENQ (3D)
2RD0 (3D)
3HHM (3D)
3HIZ (3D)
3ZIM (3D)
Secondary accessions: Q14CW1 Q99762Explore the universe of human proteins at neXtProt for PIK3CA: NX_P42336
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P42336
4/7 DME Specific Peptides for PIK3CA (P42336) (see all 7)
PIK3CA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006209.2
ENSEMBL proteins: ENSP00000418145 ENSP00000263967 ENSP00000417479 Reactome Protein details: P42336
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
TAS | -- | | GO:0005942 | phosphatidylinositol 3-kinase complex |
ISS | -- | | GO:0005943 | 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex |
IDA | -- | | GO:0030027 | lamellipodium |
IEA | -- |
PIK3CA for ontologies About GeneDecksing
PIK3CA Antibody Products:
Assay Products for PIK3CA: |
Protein
Domains /
Families
for PIK3CA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PIK3CA for domains About GeneDecksing
5/11 InterPro domains/families (see all 11):Graphical View of Domain Structure for InterPro Entry P42336ProtoNet protein and cluster: P42336 4 Blocks protein families: IPB000008 C2 domain IPB000341 Phosphoinositide 3-kinase IPB000403 Phosphatidylinositol 3- and 4-kinase IPB003113 Phosphatidylinositol 3-kinase
UniProtKB/Swiss-Prot: PK3CA_HUMAN, P42336Domain: The PI3K-ABD domain and the PI3K-RBD domain interact with the PI3K/PI4K kinase domain. The C2 PI3K-type domainmay facilitate the recruitment to the plasma membrane. The inhibitory interactions with PIK3R1 are mediated by thePI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1, and the C2 PI3K-type domain,the PI3K helical domain, and the PI3K/PI4K kinase domain with the nSH2 (N-terminal SH2) region of PIK3R1Similarity: Belongs to the PI3/PI4-kinase familySimilarity: Contains 1 C2 PI3K-type domainSimilarity: Contains 1 PI3K-ABD domainSimilarity: Contains 1 PI3K-RBD domainSimilarity: Contains 1 PI3K/PI4K domainSimilarity: Contains 1 PIK helical domain |
Function
for PIK3CA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PK3CA_HUMAN, P42336Function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P(Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generatephosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins tothe membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival,proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors.Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1,VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cellmigration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required forlymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF.Regulates invadopodia formation in breast cancer cells through the PDPK1-AKT1 pathway. Participates incardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stemcells through PDK1 and protein kinase C pathway. Has also serine-protein kinase activity: phosphorylates PIK3R1(p85alpha regulatory subunit), EIF4EBP1 and HRASCatalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol3,4,5-trisphosphateCatalytic activity: ATP + a protein = ADP + a phosphoprotein Genatlas biochemistry entry for PIK3CA:phosphatidylinositol-3-kinase,catalytic,class 1,alpha subunit,widely expressed, activated by growth factors,throughbinding p785 adaptor proteins (PIK3R1,PIK3R2,PIK3R3),activating Akts in the antiapoptotic PIK3 pathway,antagonized byPTEN,mediating angiogenes is and expression of VEGF in endothelial cells,involved in the regulation of cellularprocesses,potentially oncogenic in ovarian cancer
Enzyme Numbers (IUBMB): EC 2.7.11.11 EC 2.7.1.1531 EC 2.7.12
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3CA
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for PIK3CA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3CA |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3CA |
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table
PIK3CA for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for PIK3CA:
Animal Models:
Mouse knock-outs for PIK3CA: Pik3catm1Nbm Pik3catm1.1Jjz
15/16 MGI mutant phenotypes (inferred from 10 alleles ) (MGI details for Pik3ca) (see all 16):
PIK3CA for phenotypes About GeneDecksing
|
Pathways & Interactions
for PIK3CA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/157 super-pathways (see all 157) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development HGF signaling pathway | | | 2 | Development_CNTF receptor signaling | | | 3 | Signaling by FGFR | | | 4 | Development_PDGF signaling via STATs and NF-kB | | | 5 | PIP3 activates AKT signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/68 EMD Millipore Pathways for PIK3CA (see all 68)
1 
Cell Signaling Technology (CST) Pathway for PIK3CA
5/9 Tocris Bioscience Pathways for PIK3CA (see all 9)
5/68  GeneGo (Thomson Reuters) Pathways for PIK3CA (see all 68)
5/81  BioSystems Pathways for PIK3CA (see all 81)
5/72 
Reactome Pathways for PIK3CA (see all 72)
3  PharmGKB Pathways for PIK3CA
5/44 
Kegg Pathways (Kegg details for PIK3CA) (see all 44):
PIK3CA for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIK3CA
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/406 Interacting proteins for PIK3CA (P423361, 2, 3 ENSP000002639674) via UniProtKB, MINT, STRING, and/or I2D (see all 406)About this table
Gene Ontology (GO): 5/29 biological process terms (GO ID links to tree view) (see all 29): About this table
PIK3CA for ontologies About GeneDecksing
|
Drugs & Compounds
for PIK3CA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PIK3CA for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for PIK3CA |
Compounds for PIK3CA available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| LY 294002 hydrochloride | Selective PI 3-kinase inhibitor | [154447-36-6] | | Quercetin | Non-selective PI 3-kinase inhibitor | [117-39-5] | | PI 103 hydrochloride | Inhibitor of PI 3-kinase, mTOR and DNA-PK | [371935-74-9] | | BAG 956 | Dual PI 3-kinase and PDK1 inhibitor | [853910-02-8] | | PI 828 | PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130) | [942289-87-4] |
10/382 HMDB Compounds for PIK3CA (see all 382) About this table
1 DrugBank Compound for PIK3CA About this table
| Compound | Synonyms |
CAS
# | Type | Actions | PubMed Ids |
|---|
| (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE | -- | -- | target | -- | 10592235 |
10/86 Novoseek chemical compound relationships for PIK3CA gene (see all 86) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| phosphatidylinositol |
93.1 |
425 |
8663584 (4), 12897244 (3), 7713498 (2), 17377809 (2) (see all 99) |
| phosphoinositide |
89 |
184 |
11882383 (2), 10926936 (2), 19679877 (2), 12545728 (2) (see all 99) |
| wortmannin |
87.1 |
162 |
10794659 (3), 11559593 (3), 8657148 (2), 10671571 (2) (see all 99) |
| rapamycin |
81.3 |
71 |
20115955 (2), 18676851 (2), 12433206 (1), 19061482 (1) (see all 55) |
| phosphatidylinositol-3,4,5-trisphosphate |
74.2 |
14 |
12897244 (2), 20054340 (1), 9593670 (1), 19509113 (1) (see all 10) |
| naphtho(1,2-b)furan-4,5-dione |
71.6 |
1 |
20371243 (1), 20036260 (1) |
| ly294002 |
70.2 |
50 |
19383818 (3), 18262558 (2), 15277479 (2), 12621049 (2) (see all 28) |
| ctmp |
64.1 |
1 |
16150119 (1) |
| tyrosine |
60.1 |
62 |
10763917 (2), 16311104 (2), 18449193 (2), 10963852 (1) (see all 47) |
| glycogen |
60.1 |
22 |
17055733 (1), 18782353 (1), 20471052 (1), 16170333 (1) (see all 22) |
2 PharmGKB related drug/compound annotation for PIK3CA geneAbout this table
Search CenterWatch for drugs/clinical trials and news about PIK3CA / PK3CA
|
Transcripts
for PIK3CA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PIK3CA gene: NM_006218.2 Unigene Clusters for PIK3CA: Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Hs.553498 [show with all ESTs], Hs.715194 [show with all ESTs]Unigene Representative Sequences: AK021510, NM_0062184 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000477735 ENST00000263967(uc003fjk.3) ENST00000468036 ENST00000462255
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3CA (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3CA
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PIK3CA (NM_006218) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PIK3CA | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3CA |
Additional cDNA sequence: AB210020.1 AK292940.1 AK297203.1 AK302608.1 BC113601.1 BC113603.1 HM437241.1 U79143.1 4 DOTS entries: DT.313816 DT.99950166 DT.99939096 DT.100737416 24/74 AceView cDNA sequences (see all 74): AA331546 BG497751 BP337031 AA732379 BX437220 BX108528 N33289 AA905413 AI679006 AL706270 AI245465 AW951459 BG391265 U79143 BX482711 BX503208 CB267213 BX484734 AA298585 N44835 AU134684 CA310666 CB267994 AA661803
GeneLoc Exon Structure
|
Expression
for PIK3CA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PIK3CA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCGATTTCA
About this image
See PIK3CA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PIK3CA
SOURCE GeneReport for Unigene clusters: Hs.553498 Hs.715194
SABiosciences Expression via Pathway-Focused PCR Arrays including PIK3CA (see all 14):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PIK3CA
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PIK3CA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIK3CA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIK3CA | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3CA |
Orthologs
for PIK3CA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PIK3CA gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PIK3CA1 |
phosphoinositide-3-kinase, catalytic, alpha polypeptide |
85.3(n)
96.25(a) |
|
424971 NM_001004410.1 NP_001004410.1 |
lizard
(Anolis carolinensis) |
Reptilia |
PIK3CA6 |
-- |
95(a) |
1 ↔ 1 |
3(2309806-2331133) |
African clawed frog
(Xenopus laevis) |
Amphibia |
pik3ca-A2 |
phosphoinositide-3-kinase, catalytic, alpha subunit |
79.45(n) |
|
AF204924.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5617371 |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic more |
76.28(n)
91.76(a) |
|
561737 XM_685143.4 XP_690235.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
age-11 |
Protein AGE-1 |
45.18(n)
31.66(a) |
|
174762 NM_064061.3 NP_496462.1 |
ENSEMBL Gene Tree for PIK3CA (if available)
TreeFam Gene Tree for PIK3CA (if available) |
Paralogs
for PIK3CA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PIK3CA gene
- PIK3CD2 PIK3C2B2 PIK3C2G2 PIK3CG2 PIK3C32 PIK3CB2 PIK3C2A2
5 SIMAP similar genes for PIK3CA using alignment to 4 protein entries: PK3CA_HUMAN (see all proteins):PIK3CA variant protein DKFZp779K1237 PIK3CB PIK3CD PIK3CG
PIK3CA for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for PIK3CA
PGOHUM00000246382
|
Genomic Variants
for PIK3CA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PIK3CA (178865902 - 178957881 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PIK3CA
1 CNV: 91720
1 Indel: 59111
Human Gene Mutation Database (HGMD): PIK3CA
| 5/63 SABiosciences Cancer Mutation PCR Assays for PIK3CA (see all 63): |
| 5/31 SABiosciences Cancer Mutation PCR Arrays containing PIK3CA (see all 31): |
| 3 SABiosciences qBiomarker Copy Number PCR Arrays containing PIK3CA: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PIK3CA |
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Disorders
/ Diseases
for PIK3CA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PIK3CA for disorders About GeneDecksing
OMIM gene information: 171834
OMIM disorders: 604370 114480 114500 137215 114550 211980 182000 162900
UniProtKB/Swiss-Prot: PK3CA_HUMAN, P42336
Note=Most of the cancer-derived mutations are missense mutations and map to one of the three hotspots:Glu-542; Glu-545 and His-1047. Mutated isoforms participate in cellular transformation and tumorigenesis induced byoncogenic receptor tyrosine kinases (RTKs) and HRAS1/KRAS. Interaction with HRAS1/KRAS is required for Ras-driventumor formation. Mutations increasing the lipid kinase activity are required for oncogenic signaling. The proteinkinase activity may not be required for tumorigenesis Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500] Defects in PIK3CA are a cause of susceptibility to breast cancer (BC) [MIM:114480]. A common malignancyoriginating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasiveductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous.Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more thanone locus can be involved in different families or even in the same case Defects in PIK3CA are a cause of susceptibility to ovarian cancer (OC) [MIM:167000]. Ovarian cancer commonmalignancy originating from ovarian tissue. Although many histologic types of ovarian neoplasms have been described,epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signsand symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease Defects in PIK3CA may underlie hepatocellular carcinoma (HCC) [MIM:114550] Defects in PIK3CA are a cause of keratosis seborrheic (KERSEB) [MIM:182000]. A common benign skin tumor.Seborrheic keratoses usually begin with the appearance of one or more sharply defined, light brown, flat macules. Thelesions may be sparse or numerous. As they initially grow, they develop a velvety to finely verrucous surface,followed by an uneven warty surface with multiple plugged follicles and a dull or lackluster appearance Defects in PIK3CA are the cause of congenital lipomatous overgrowth, vascular malformations, and epidermalnevi (CLOVE) [MIM:612918]. CLOVE is a sporadically occurring, non-hereditary disorder characterized by asymmetricsomatic hypertrophy and anomalies in multiple organs. It is defined by four main clinical findings: congenitallipomatous overgrowth, vascular malformations, epidermal nevi, and skeletal/spinal abnormalities. The presence oftruncal overgrowth and characteristic patterned macrodactyly at birth differentiates CLOVE from other syndromic formsof overgrowth
20/158  diseases for PIK3CA (see all 158): About MalaCardscervical cancer keratosis, seborrheic, somatic nonsmall cell lung cancer, somatic cervicitis
estrogen-receptor positive breast cancer ethmoid sinusitis diffuse large b-cell lymphoma focal cortical dysplasia
ethmoid sinus adenocarcinoma b-cell lymphomas lung cancer, somatic ampulla of vater carcinoma
anaplastic large cell lymphoma adult glioblastoma multiforme malignant pleural mesothelioma non-hodgkin lymphoma
clear cell adenocarcinoma squamous cell carcinoma hepatocellular carcinoma, somatic cervical intraepithelial neoplasia
6 diseases from the University of Copenhagen DISEASES database for PIK3CA:Colorectal cancer Carcinoma Breast cancer Endometrial cancer
Lung cancer Ovarian cancer 10/80 Novoseek disease relationships for PIK3CA gene (see all 80) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cancer |
68.6 |
291 |
19573809 (6), 19384426 (5), 18059185 (4), 17575152 (4) (see all 99) |
| somatic mutations |
68.1 |
59 |
16168105 (4), 17052259 (3), 16533766 (2), 18951408 (2) (see all 33) |
| tumors |
65.5 |
343 |
17714348 (7), 15928251 (6), 19237633 (5), 16322209 (4) (see all 99) |
| glioblastoma |
65.2 |
58 |
17235514 (5), 18676851 (5), 17050665 (4), 12782577 (4) (see all 22) |
| follicular thyroid cancer |
61.6 |
4 |
15928251 (2), 17426084 (1) |
| thyroid carcinoma anaplastic |
60.9 |
5 |
16288007 (2), 15928251 (1), 18000091 (1), 18502332 (1) |
| breast cancer |
56.5 |
135 |
16168105 (7), 19685490 (5), 17202311 (5), 18676830 (4) (see all 57) |
| cowden disease |
55.9 |
1 |
19897009 (1) |
| glioblastoma multiforme |
51.8 |
4 |
17050665 (1), 15924253 (1), 15143086 (1) |
| ovarian cancer |
51.7 |
46 |
12874030 (4), 16839745 (3), 15028555 (3), 18270270 (3) (see all 23) |
Genetic Association Database (GAD): PIK3CA
Human Genome Epidemiology (HuGE) Navigator: PIK3CA (129 documents)
Export disorders for PIK3CA gene to outside databases
|
Publications
for PIK3CA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PIK3CA gene, integrated from 9 sources (see all 1415):
(articles sorted by number of sources associating them with PIK3CA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- PIK3CA mutation and histological type in breast carcinoma: high frequency of mutations in lobular carcinoma. (PubMed id 16353168)1, 2, 4 Buttitta F....Marchetti A. (2006)
- The prevalence of PIK3CA mutations in gastric and colon cancer. (PubMed id 15994075)1, 2, 4 Velho S....Seruca R. (2005)
- Mutations of PIK3CA in gastric adenocarcinoma. (PubMed id 15784156)1, 2, 9 Li V.S.W.... Leung S.Y. (2005)
- Somatic mutation and gain of copy number of PIK3CA in human breast cancer. (PubMed id 16168105)1, 4, 9 Wu G....Sidransky D. (2005)
- High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma. (PubMed id 16322209)1, 2, 9 Oda K.... McCormick F. (2005)
- PIK3CA mutations in head and neck squamous cell carcinoma. (PubMed id 16533766)1, 2, 9 Qiu W.... Su G.H. (2006)
- Uncommon mutation, but common amplifications, of the PIK3CA gene in thyroid tumors. (PubMed id 15928251)1, 4, 9 Wu G....Xing M. (2005)
- Mutation of the PIK3CA gene in ovarian and breast cancer. (PubMed id 15520168)1, 2, 9 Campbell I.G....Phillips W.A. (2004)
- Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern. (PubMed id 17673550)1, 2, 9 Hafner C....Real F.X. (2007)
- PIK3CA mutations in breast cancer are associated with poor outcome. (PubMed id 16317585)1, 4, 9 Li S.Y....Iacopetta B. (2006)
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External Searches for PIK3CA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing PIK3CA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing PIK3CA gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PIK3CA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
|
About This Section
| Patent Information for PIK3CA gene:
Search GeneIP for patents involving PIK3CA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PIK3CA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | OriGene Antibodies for PIK3CA | | OriGene shRNA RFP for PIK3CA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PIK3CA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PIK3CA | | | OriGene Protein Over-expression Lysate for PIK3CA | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PIK3CA | | OriGene 3'-UTR Clone for PIK3CA | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3CA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3CA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PIK3CA | | OriGene Custom Protein Services for PIK3CA | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PIK3CA | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PIK3CA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIK3CA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIK3CA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIK3CA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIK3CA |
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| | Antibodies & Assays for PIK3CA |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3CA |
|  |  |  | | | | ThermoFisher Antibodies for PIK3CA |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3CA |
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