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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PIK3CA Gene

protein-coding   GIFtS: 73
GCID: GC03P178865

Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic...

(Previous names: phosphoinositide-3-kinase, catalytic, alpha polypeptide)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic Subunit
Alpha1 2
     Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha
Isoform2
Phosphoinositide-3-Kinase, Catalytic, Alpha Polypeptide1 2     Phosphatidylinositol-4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit
Alpha2
PtdIns-3-Kinase Subunit P110-Alpha2 3     Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit, Alpha
Isoform2
Serine/Threonine Protein Kinase PIK3CA2 3     PI3-Kinase P110 Subunit Alpha2
PI3K-alpha2 3     EC 2.7.1.1533
CLOVE2     EC 2.7.11.13
CWS52     PI3Kalpha3
MCAP2     p110alpha3
MCM2     Phosphatidylinositol 4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit
Alpha3
MCMTC2     Phosphoinositide-3-Kinase Catalytic Alpha Polypeptide3
PI3K2     PI3-Kinase Subunit Alpha3
p110-alpha2     PtdIns-3-Kinase Subunit Alpha3
Phosphatidylinositol 3-Kinase, Catalytic, 110-KD, Alpha2     EC 2.7.18
Phosphatidylinositol 3-Kinase, Catalytic, Alpha Polypeptide2     

External Ids:    HGNC: 89751   Entrez Gene: 52902   Ensembl: ENSG000001218797   OMIM: 1718345   UniProtKB: P423363   

Export aliases for PIK3CA gene to outside databases

Previous GC identifers: GC03P175570 GC03P179758 GC03P180318 GC03P180237 GC03P180399 GC03P180349 GC03P176269


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PIK3CA Gene:
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The
protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P
and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.
(provided by RefSeq, Jul 2008)

GeneCards Summary for PIK3CA Gene: 
PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha) is a protein-coding gene. Diseases associated with PIK3CA include hemimegalencephaly, and ethmoid sinus adenocarcinoma, and among its related super-pathways are Development EGFR signaling via small GTPases and Translation Insulin regulation of translation. GO annotations related to this gene include protein kinase activator activity and protein serine/threonine kinase activity. An important paralog of this gene is PIK3C2B.

UniProtKB/Swiss-Prot: PK3CA_HUMAN, P42336
Function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P
(Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate
phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing
proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth,
survival, proliferation, motility and morphology. Participates in cellular signaling in response to various
growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as
EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins.
Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by
regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by
activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation in breast cancer cells through the
PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates
in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Has also serine-protein
kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS

summary for PIK3CA Gene:
PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the
3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of
cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell
migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric
consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and
delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst
p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have
recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes
(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI
3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to
play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3CA (P110α) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PIK3CA gene promoter:
         PPAR-gamma1   FOXO4   FOXO1a   CUTL1   PPAR-gamma2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIK3CA promoter sequence
   Search SABiosciences Chromatin IP Primers for PIK3CA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIK3CA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.3   Ensembl cytogenetic band:  3q26.32   HGNC cytogenetic band: 3q26.3

PIK3CA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIK3CA gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P178865:  view genomic region     (about GC identifiers)

Start:
178,865,902 bp from pter      End:
178,957,881 bp from pter
Size:
91,980 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PK3CA_HUMAN, P42336 (See protein sequence)
Recommended Name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform  
Size: 1068 amino acids; 124284 Da
Subunit: Heterodimer of a catalytic subunit PIK3CA and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3).
Interacts with IRS1 in nuclear extracts. Interacts with RUFY3 (By similarity). Interacts with RASD2 (By
similarity). Interacts with APPL1. Interacts with HRAS1 and KRAS (By similarity). Interaction with HRAS1/KRAS is
required for PI3K pathway signaling and cell proliferation stimulated by EGF and FGF2 (By similarity)
Miscellaneous: The avian sarcoma virus 16 genome encodes an oncogene derived from PIK3CA (PubMed:18418043)
5 PDB 3D structures from and Proteopedia for PIK3CA:
2ENQ (3D)        2RD0 (3D)        3HHM (3D)        3HIZ (3D)        3ZIM (3D)    
Secondary accessions: Q14CW1 Q99762

Explore the universe of human proteins at neXtProt for PIK3CA: NX_P42336

Explore proteomics data for PIK3CA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P42336

  • 4/7 DME Specific Peptides for PIK3CA (P42336) (see all 7)
     SCAGYCV  DLRQDML  LFHIDFG  LTDILKQ 

    PIK3CA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PIK3CA Protein Expression
    REFSEQ proteins: NP_006209.2  
    ENSEMBL proteins: 
     ENSP00000418145   ENSP00000263967   ENSP00000417479  
    Reactome Protein details: P42336
    Human Recombinant Protein Products for PIK3CA: 
    EMD Millipore Purified and/or Recombinant PIK3CA Protein
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    OriGene Custom Protein Services for PIK3CA
    GenScript Custom Purified and Recombinant Proteins Services for PIK3CA
    Novus Biologicals PIK3CA Protein
    Novus Biologicals PIK3CA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IBA--
    GO:0005942phosphatidylinositol 3-kinase complex ISS--
    GO:00059431-phosphatidylinositol-4-phosphate 3-kinase, class IA complex IDA--
    GO:0030027lamellipodium IEA--

    PIK3CA for ontologies           About GeneDecksing



    PIK3CA Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 
    Phosphatidylinositol-4,5-bisphosphate 3-kinase family

    5/11 InterPro protein domains (see all 11):
     IPR001263 PInositide-3_kin_accessory_dom
     IPR003113 PI3K_adapt-bd_dom
     IPR002420 PI3K_C2_dom
     IPR011009 Kinase-like_dom
     IPR000403 PI3/4_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P42336

    ProtoNet protein and cluster: P42336

    4 Blocks protein domains:
    IPB000008 C2 domain
    IPB000341 Phosphoinositide 3-kinase
    IPB000403 Phosphatidylinositol 3- and 4-kinase
    IPB003113 Phosphatidylinositol 3-kinase


    UniProtKB/Swiss-Prot: PK3CA_HUMAN, P42336
    Domain: The PI3K-ABD domain and the PI3K-RBD domain interact with the PI3K/PI4K kinase domain. The C2 PI3K-type
    domain may facilitate the recruitment to the plasma membrane. The inhibitory interactions with PIK3R1 are
    mediated by the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1, and the
    C2 PI3K-type domain, the PI3K helical domain, and the PI3K/PI4K kinase domain with the nSH2 (N-terminal SH2)
    region of PIK3R1
    Similarity: Belongs to the PI3/PI4-kinase family
    Similarity: Contains 1 C2 PI3K-type domain
    Similarity: Contains 1 PI3K-ABD domain
    Similarity: Contains 1 PI3K-RBD domain
    Similarity: Contains 1 PI3K/PI4K domain
    Similarity: Contains 1 PIK helical domain


    PIK3CA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PK3CA_HUMAN, P42336
    Function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P
    (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate
    phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing
    proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth,
    survival, proliferation, motility and morphology. Participates in cellular signaling in response to various
    growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as
    EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins.
    Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by
    regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by
    activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation in breast cancer cells through the
    PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates
    in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Has also serine-protein
    kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS
    Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol
    3,4,5-trisphosphate
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for PIK3CA:
    phosphatidylinositol-3-kinase,catalytic,class 1,alpha subunit,widely expressed, activated by growth
    factors,through binding p785 adaptor proteins (PIK3R1,PIK3R2,PIK3R3),activating Akts in the antiapoptotic PIK3
    pathway,antagonized by PTEN,mediating angiogenes is and expression of VEGF in endothelial cells,involved in the
    regulation of cellular processes,potentially oncogenic in ovarian cancer

         Enzyme Numbers (IUBMB): EC 2.7.11.11 EC 2.7.1.1531 EC 2.7.12

         Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI10490823
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity TAS--
         
    PIK3CA for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PIK3CA:
     Increased cell death in HCT116 

         15/17 MGI mutant phenotypes (inferred from 11 alleles(MGI details for Pik3ca) (see all 17):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  embryogenesis 
     endocrine/exocrine gland  growth/size  homeostasis/metabolism  immune system  integument 
     mortality/aging  muscle  nervous system  no phenotypic analysis  reproductive system 

    PIK3CA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PIK3CA: Pik3catm1Nbm Pik3catm1.1Jjz

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PIK3CA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PIK3CA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PIK3CA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PIK3CA 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIK3CA
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate PIK3CA (see all 13):
    hsa-miR-3910 hsa-miR-203 hsa-miR-1206 hsa-miR-561 hsa-miR-10b hsa-miR-10a hsa-miR-124 hsa-miR-19b
    SwitchGear 3'UTR luciferase reporter plasmidPIK3CA 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for PIK3CA
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    Gene Editing
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                         Customized adenovirus for overexpression of PIK3CA

    Clone
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PIK3CA About   (see all 163)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development HGF signaling pathway
    Development HGF signaling pathway0.78
    Apoptosis and survival NGF signaling pathway0.36
    Development Neurotrophin family signaling0.45
    Neurotrophin signaling pathway0.36
    Development EGFR signaling via small GTPases0.44
    Signaling of Hepatocyte Growth Factor Receptor0.35
    Development PDGF signaling via MAPK cascades0.41
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR10.35
    2Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Cell adhesion PLAU signaling0.35
    Regulation of lipid metabolism Insulin signaling:generic cascades0.59
    Development Growth hormone signaling via PI3K/AKT and MAPK cascades0.34
    Transcription Receptor-mediated HIF regulation0.51
    mTOR signaling pathway0.34
    Translation Regulation activity of EIF20.47
    Insulin signaling pathway0.31
    3Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.45
    Fc-epsilon receptor I signaling in mast cells0.33
    Immune response BCR pathway0.45
    Immune response CD16 signaling in NK cells0.32
    Fc epsilon RI signaling pathway0.40
    Immune response Role of DAP12 receptors in NK cells0.32
    VEGF signaling pathway0.39
    Natural killer cell mediated cytotoxicity0.31
    4Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    5Development Prolactin receptor signaling
    Development Prolactin receptor signaling0.39
    Prolactin signaling pathway0.33
    Prolactin Signaling Pathway0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/68 EMD Millipore Pathways for PIK3CA (see all 68)
        Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling FAK signaling
    Cytoskeleton remodeling Role of PDGFs in cell migration
    Development PDGF signaling via MAPK cascades
    Development A2A receptor signaling


    1 Cell Signaling Technology (CST) Pathway for PIK3CA
        PI3K / Akt Signaling

    5/9 Tocris Bioscience Pathways for PIK3CA (see all 9)
        Akt Pathway
    Insulin Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    Toll-like Receptor Pathway

    5/68 GeneGo (Thomson Reuters) Pathways for PIK3CA (see all 68)
        G-protein signaling H-RAS regulation pathway
    Development A2A receptor signaling
    Development CNTF receptor signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway

    5/82 BioSystems Pathways for PIK3CA (see all 82)
        Angiogenesis
    MicroRNAs in cardiomyocyte hypertrophy
    Focal Adhesion
    Keap1-Nrf2 Pathway
    EGFR1 Signaling Pathway

    5/73        Reactome Pathways for PIK3CA (see all 73)
        Nephrin interactions
    IRS-mediated signalling
    Signaling by PDGF
    Downstream Signaling Events Of B Cell Receptor (BCR)
    Signalling by NGF

    3 PharmGKB Pathways for PIK3CA
        Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Sorafenib Pharmacodynamics

    5/56         Kegg Pathways  (Kegg details for PIK3CA) (see all 56):
        Inositol phosphate metabolism
    ErbB signaling pathway
    Chemokine signaling pathway
    HIF-1 signaling pathway
    Phosphatidylinositol signaling system


    PIK3CA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIK3CA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/406 Interacting proteins for PIK3CA (P423361, 2, 3 ENSP000002639674) via UniProtKB, MINT, STRING, and/or I2D (see all 406)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279861, 2, 3, ENSP000002743354EBI-2116585,EBI-79464 MINT-6170530 MINT-7383676 MINT-7298487 I2D: score=9 STRING: ENSP00000274335
    IRS1P355682, 3, ENSP000003048954MINT-68707 I2D: score=2 STRING: ENSP00000304895
    GNAQP501483, ENSP000002865484I2D: score=3 STRING: ENSP00000286548
    LCKP062393, ENSP000003378254I2D: score=3 STRING: ENSP00000337825
    TICAM1Q8IUC63, ENSP000002482444I2D: score=3 STRING: ENSP00000248244
    About this table

    Gene Ontology (GO): 5/33 biological process terms (GO ID links to tree view) (see all 33):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001944vasculature development TAS19200708
    GO:0006006glucose metabolic process IEA--
    GO:0006468protein phosphorylation ----
    GO:0006644phospholipid metabolic process TAS--

    PIK3CA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PIK3CA for compounds           About GeneDecksing

    EMD Millipore small molecules for PIK3CA:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for PIK3CA

    Compounds for PIK3CA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CZC 24832Selective inhibitor of PI 3-Kinase gamma[1159824-67-5]
    QuercetinNon-selective PI 3-kinase inhibitor[117-39-5]
    PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK [371935-74-9]
    AS 605240Potent and selective PI 3-kinase gamma (PI3Kgamma) inhibitor[648450-29-7]
    740 Y-PCell-permeable PI 3-kinase activator[1236188-16-1]

    10/382 HMDB Compounds for PIK3CA (see all 382)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Phosphatidyl-D-myo-inositol1-Phosphatidyl-1D-myo-inositol (see all 6)----
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    PI(16:0/16:0)Phosphatidylinositol(32:0) (see all 8)----
    PI(16:0/16:1(9Z))Phosphatidylinositol(32:1) (see all 14)----
    PI(16:0/16:2(9Z,12Z))Phosphatidylinositol(16:0/16:2n4) (see all 18)----
    PI(16:0/18:0)Phosphatidylinositol(16:0/18:0) (see all 8)----
    PI(16:0/18:1(11Z))Phosphatidylinositol(16:0/18:1w7) (see all 14)----
    PI(16:0/18:1(9Z))Phosphatidylinositol(16:0/18:1) (see all 14)----
    PI(16:0/18:2(9Z,12Z))PIno(16:0/18:2) (see all 14)----

    1 DrugBank Compound for PIK3CA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE-- --target--10592235

    10/86 Novoseek inferred chemical compound relationships for PIK3CA gene (see all 86)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 93.1 425 8663584 (4), 12897244 (3), 7713498 (2), 17377809 (2) (see all 99)
    phosphoinositide 89 184 11882383 (2), 10926936 (2), 19679877 (2), 12545728 (2) (see all 99)
    wortmannin 87.1 162 10794659 (3), 11559593 (3), 8657148 (2), 10671571 (2) (see all 99)
    rapamycin 81.3 71 20115955 (2), 18676851 (2), 12433206 (1), 19061482 (1) (see all 55)
    phosphatidylinositol-3,4,5-trisphosphate 74.2 14 12897244 (2), 20054340 (1), 9593670 (1), 19509113 (1) (see all 10)
    naphtho(1,2-b)furan-4,5-dione 71.6 1 20371243 (1), 20036260 (1)
    ly294002 70.2 50 19383818 (3), 18262558 (2), 15277479 (2), 12621049 (2) (see all 28)
    ctmp 64.1 1 16150119 (1)
    tyrosine 60.1 62 10763917 (2), 16311104 (2), 18449193 (2), 10963852 (1) (see all 47)
    glycogen 60.1 22 17055733 (1), 18782353 (1), 20471052 (1), 16170333 (1) (see all 22)

    1 PharmGKB related drug/compound annotation for PIK3CA gene    About this table
    Drug/compound PharmGKB Annotation
    docetaxelCA  

    Search CenterWatch for drugs/clinical trials and news about PIK3CA / PK3CA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PIK3CA gene: 
    NM_006218.2  

    Unigene Clusters for PIK3CA:

    Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
    Hs.553498  [show with all ESTs], Hs.715194  [show with all ESTs]
    Unigene Representative Sequences: AK021510, NM_006218
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477735 ENST00000263967(uc003fjk.3) ENST00000468036 ENST00000462255

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIK3CA
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate PIK3CA (see all 13):
    hsa-miR-3910 hsa-miR-203 hsa-miR-1206 hsa-miR-561 hsa-miR-10b hsa-miR-10a hsa-miR-124 hsa-miR-19b
    SwitchGear 3'UTR luciferase reporter plasmidPIK3CA 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIK3CA
    Clone
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    OriGene clones in human, mouse for PIK3CA (see all 7)
    OriGene ORF clones in mouse, rat for PIK3CA
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    GenScript: all cDNA clones in your preferred vector: PIK3CA (NM_006218)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIK3CA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3CA
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                         Customized lentivirus expression plasmids for stable overexpression of PIK3CA 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIK3CA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIK3CA

    Additional mRNA sequence: 

    AB210020.1 AK292940.1 AK297203.1 AK302608.1 BC113601.1 BC113603.1 HM437241.1 U79143.1 

    4 DOTS entries:

    DT.313816  DT.99950166  DT.99939096  DT.100737416 

    24/74 AceView cDNA sequences (see all 74):

    AI679006 BX108528 AL706270 AA905413 BG497751 BP337031 AA331546 AA732379 
    BX437220 N33289 BX473473 BE279196 BU167122 BX482711 BX491368 BX503208 
    N44835 AW951459 BP336348 AU129890 AI628512 U79143 CB267213 AU134684 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PIK3CA expression in normal human tissues (normalized intensities)      PIK3CA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGATTTCA
    PIK3CA Expression
    About this image


    PIK3CA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Spinal Cord (Nervous System)
             motor neurons   
     
     Lymph (Hematopoietic System)
             LYMPH NODE   

    See PIK3CA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PIK3CA

    SOURCE GeneReport for Unigene clusters: Hs.553498 Hs.715194
        SABiosciences Expression via Pathway-Focused PCR Arrays including PIK3CA (see all 14): 
              mTOR Signaling in human mouse rat
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              VEGF Signaling in human mouse rat
              Cell Motility in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIK3CA
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3CA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PIK3CA gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pik3ca1 , 5 phosphatidylinositol 3-kinase, catalytic, alpha polypeptide1, 5 89.64(n)1
    98.69(a)1
      3 (15.70 cM)5
    187061  NM_008839.21  NP_032865.21 
     323976715 
    chicken
    (Gallus gallus)
    Aves PIK3CA1 phosphoinositide-3-kinase, catalytic, alpha polypeptide 85.3(n)
    96.25(a)
      424971  NM_001004410.1  NP_001004410.1 
    lizard
    (Anolis carolinensis)
    Reptilia PIK3CA6
    --
    --
    95(a)
    85(a)
    1 ↔ 1
    possible ortholog
    3(2307494-2331193)
    GL343895.1(77126-137994)
    African clawed frog
    (Xenopus laevis)
    Amphibia pik3ca-A2 phosphoinositide-3-kinase, catalytic, alpha subunit 79.45(n)    AF204924.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5617371 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic more 76.28(n)
    91.76(a)
      561737  XM_685143.4  XP_690235.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pi3K92E3 insulin receptor signaling pathway
    phosphatidylinositol more
    34(a)   92F3   --
    worm
    (Caenorhabditis elegans)
    Secernentea age-11 Protein AGE-1 45.18(n)
    31.66(a)
      174762  NM_064061.3  NP_496462.1 


    ENSEMBL Gene Tree for PIK3CA (if available)
    TreeFam Gene Tree for PIK3CA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PIK3CA gene
    PIK3C2B2  PIK3CD2  PIK3C2G2  PIK3CG2  PIK3C32  PIK3CB2  PIK3C2A2  
    5 SIMAP similar genes for PIK3CA using alignment to 4 protein entries:     PK3CA_HUMAN (see all proteins):
    PIK3CA variant protein    DKFZp779K1237    PIK3CB    PIK3CD    PIK3CG

    PIK3CA for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PIK3CA
    PGOHUM00000246382


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1821 SNPs in PIK3CA are shown (see all 1821)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0692524
    Megalencephaly-capillary malformation-polymicrogyria syndrome (MCAP)4--see VAR_0692522 G R mis40--------
    VAR_0261694
    Cancer4--see VAR_0261692 Y C mis40--------
    VAR_0692584
    Megalencephaly-capillary malformation-polymicrogyria syndrome (MCAP)4--see VAR_0692582 T A mis40--------
    VAR_0261964
    Cancer4--see VAR_0261962 H L mis40--------
    VAR_0261904
    Megalencephaly-capillary malformation-polymicrogyria syndrome (MCAP)4--see VAR_0261902 M I mis40--------
    VAR_0261804
    Cancer4--see VAR_0261802 Q K mis40--------
    VAR_0692564
    Megalencephaly-capillary malformation-polymicrogyria syndrome (MCAP)4--see VAR_0692562 E K mis40--------
    VAR_0261844
    Megalencephaly-capillary malformation-polymicrogyria syndrome (MCAP)4--see VAR_0261842 Y C mis40--------
    VAR_0261954
    Cancer4--see VAR_0261952 T K mis40--------
    VAR_0261724
    Cancer4--see VAR_0261722 E Q mis40--------

    HapMap Linkage Disequilibrium report for PIK3CA (178865902 - 178957881 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for PIK3CA (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2659099CNV Deletion23128226
    esv2726256CNV Deletion23290073
    esv1007496CNV Loss20482838
    nsv524471CNV Loss19592680
    nsv822351CNV Loss20364138
    nsv878037CNV Loss21882294
    dgv5352n71CNV Loss21882294
    nsv461026CNV Gain19166990
    nsv829806CNV Gain17160897
    nsv819800CNV Gain19587683


    Human Gene Mutation Database (HGMD): PIK3CA
    5/63 SABiosciences Cancer Mutation PCR Assays for PIK3CA (see all 63):
    Cosmic IdAA Change
    12458p.E545A
    17443p.G1007R
    12590p.T1025S
    12580p.K111N
    771p.T1025A
    5/31 SABiosciences Cancer Mutation PCR Arrays containing PIK3CA (see all 31):
    Breast Cancer
    Receptor Tyrosine Kinase (RTK) (Panel II)
    Cancer Comprehensive Panel 384HT
    Lung Cancer
    3 SABiosciences qBiomarker Copy Number PCR Arrays containing PIK3CA:
    Oncogenes & Tumor Suppressor Genes 384HC
    Lung Cancer
    Kinases & Phosphatases
    SeqTarget long-range PCR primers for resequencing PIK3CA
    DNA2.0 Custom Variant and Variant Library Synthesis for PIK3CA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 171834   
    OMIM disorders: 604370  114480  114500  137215  114550  211980  182000  162900  
    UniProtKB/Swiss-Prot: PK3CA_HUMAN, P42336
  • Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from
    the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with
    progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon
    and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The gene
    represented in this entry may be involved in disease pathogenesis
  • Breast cancer (BC) [MIM:114480]: A common malignancy originating from breast epithelial tissue. Breast
    neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common
    type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated
    by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different
    families or even in the same case. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry
  • Ovarian cancer (OC) [MIM:167000]: The term ovarian cancer defines malignancies originating from ovarian
    tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the
    most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of
    late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry
  • Hepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The
    major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV)
    infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. Note=The
    gene represented in this entry may be involved in disease pathogenesis
  • Note=Most of the cancer-derived mutations are missense mutations and map to one of the three hotspots:
    Glu-542; Glu-545 and His-1047. Mutated isoforms participate in cellular transformation and tumorigenesis induced
    by oncogenic receptor tyrosine kinases (RTKs) and HRAS1/KRAS. Interaction with HRAS1/KRAS is required for
    Ras-driven tumor formation. Mutations increasing the lipid kinase activity are required for oncogenic signaling.
    The protein kinase activity may not be required for tumorigenesis
  • Keratosis, seborrheic (KERSEB) [MIM:182000]: A common benign skin tumor. Seborrheic keratoses usually
    begin with the appearance of one or more sharply defined, light brown, flat macules. The lesions may be sparse or
    numerous. As they initially grow, they develop a velvety to finely verrucous surface, followed by an uneven warty
    surface with multiple plugged follicles and a dull or lackluster appearance. Note=The disease is caused by
    mutations affecting the gene represented in this entry
  • Megalencephaly-capillary malformation-polymicrogyria syndrome (MCAP) [MIM:602501]: A syndrome
    characterized by a spectrum of anomalies including primary megalencephaly, prenatal overgrowth, brain and body
    asymmetry, cutaneous vascular malformations, digital anomalies consisting of syndactyly with or without postaxial
    polydactyly, connective tissue dysplasia involving the skin, subcutaneous tissue, and joints, and cortical brain
    malformations, most distinctively polymicrogyria. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome (MPPH) [MIM:603387]: A syndrome
    characterized by megalencephaly, hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is
    considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE) [MIM:612918]: A
    sporadically occurring, non-hereditary disorder characterized by asymmetric somatic hypertrophy and anomalies in
    multiple organs. It is defined by four main clinical findings: congenital lipomatous overgrowth, vascular
    malformations, epidermal nevi, and skeletal/spinal abnormalities. The presence of truncal overgrowth and
    characteristic patterned macrodactyly at birth differentiates CLOVE from other syndromic forms of overgrowth.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/155 diseases for PIK3CA (see all 155):    About MalaCards
    hemimegalencephaly    ethmoid sinus adenocarcinoma    ethmoid sinusitis    macrodactyly of fingers, unilateral
    keratosis, seborrheic, somatic    segmental progressive overgrowth syndrome with fibroadipose hyperplasia    cervical cancer    adult glioblastoma multiforme
    colorectal cancer, hereditary nonpolyposis, type 1    cervicitis    penile cancer    lung cancer, somatic
    nonsmall cell lung cancer, somatic    cowden disease    breast cancer, somatic    hepatocellular carcinoma, somatic
    primary malignant lymphoma    colorectal cancer, somatic    nephrogenic systemic fibrosis    gastric cancer, somatic

    6 diseases from the University of Copenhagen DISEASES database for PIK3CA:
    Colorectal cancer     Carcinoma     Breast cancer     Endometrial cancer
    Ovarian cancer     Lung cancer

    PIK3CA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/80 Novoseek inferred disease relationships for PIK3CA gene (see all 80)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 68.6 291 19573809 (6), 19384426 (5), 18059185 (4), 17575152 (4) (see all 99)
    somatic mutations 68.1 59 16168105 (4), 17052259 (3), 16533766 (2), 18951408 (2) (see all 33)
    tumors 65.5 343 17714348 (7), 15928251 (6), 19237633 (5), 16322209 (4) (see all 99)
    glioblastoma 65.2 58 17235514 (5), 18676851 (5), 17050665 (4), 12782577 (4) (see all 22)
    follicular thyroid cancer 61.6 4 15928251 (2), 17426084 (1)
    thyroid carcinoma anaplastic 60.9 5 16288007 (2), 15928251 (1), 18000091 (1), 18502332 (1)
    breast cancer 56.5 135 16168105 (7), 19685490 (5), 17202311 (5), 18676830 (4) (see all 57)
    cowden disease 55.9 1 19897009 (1)
    glioblastoma multiforme 51.8 4 17050665 (1), 15924253 (1), 15143086 (1)
    ovarian cancer 51.7 46 12874030 (4), 16839745 (3), 15028555 (3), 18270270 (3) (see all 23)

    Genetic Association Database (GAD): PIK3CA
    Human Genome Epidemiology (HuGE) Navigator: PIK3CA (129 documents)

    Export disorders for PIK3CA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PIK3CA gene, integrated from 9 sources (see all 1498):
    (articles sorted by number of sources associating them with PIK3CA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PIK3CA mutation and histological type in breast carcinoma: high frequency of mutations in lobular carcinoma. (PubMed id 16353168)1, 2, 4 Buttitta F....Marchetti A. (2006)
    2. The prevalence of PIK3CA mutations in gastric and colon cancer. (PubMed id 15994075)1, 2, 4 Velho S....Seruca R. (2005)
    3. Mutations of PIK3CA in gastric adenocarcinoma. (PubMed id 15784156)1, 2, 9 Li V.S.W.... Leung S.Y. (2005)
    4. Molecular analysis of PIK3CA, BRAF, and RAS oncogenes in periampullary and ampullary adenomas and carcinomas. (PubMed id 19440799)1, 4, 9 SchAPnleben F....Su G.H. (2009)
    5. Vitamin D receptor expression is associated with PIK3 CA and KRAS mutations in colorectal cancer. (PubMed id 19789368)1, 4, 9 Kure S....Ogino S. (2009)
    6. Clinicopathological analysis of papillary thyroid cancer with PIK3CA alterations in a Middle Eastern population. (PubMed id 18000091)1, 4, 9 Abubaker J....Al-Kuraya K.S. (2008)
    7. PIK3CA mutation is predictive of poor survival in patients with colorectal cancer. (PubMed id 17590872)1, 4, 9 Kato S....Sugihara K. (2007)
    8. Somatic mutation and gain of copy number of PIK3CA in human breast cancer. (PubMed id 16168105)1, 4, 9 Wu G....Sidransky D. (2005)
    9. High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma. (PubMed id 16322209)1, 2, 9 Oda K.... McCormick F. (2005)
    10. PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer. (PubMed id 19237633)1, 4, 9 Ogino S....Fuchs C.S. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5290 HGNC: 8975 AceView: PIK3CA Ensembl:ENSG00000121879 euGenes: HUgn5290
    ECgene: PIK3CA Kegg: 5290 H-InvDB: PIK3CA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PIK3CA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PIK3CA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PIK3CA gene:
    Search GeneIP for patents involving PIK3CA

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Kits and Assays for the Analysis of PIK3CA
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PIK3CA
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore small molecules (inhibitor) for PIK3CA
     EMD Millipore Purified and/or Recombinant PIK3CA Protein
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
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     OriGene Antibodies for PIK3CA   OriGene RNAi products in human, mouse, rat for PIK3CA  
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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PIK3CA
     QIAGEN SeqTarget long-range PCR primers for resequencing PIK3CA
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIK3CA
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIK3CA
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIK3CA
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIK3CA
     GenScript Custom Purified and Recombinant Proteins Services for PIK3CA GenScript cDNA clones with any tag delivered in your preferred vector for PIK3CA
     GenScript Custom Assay Services for PIK3CA GenScript Custom Superior Antibodies Services for PIK3CA
     GenScript Custom overexpressing Cell Line Services for PIK3CA CloneReady with Over 120,000 Genes
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     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
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     Antibodies & Assays for PIK3CA 

     Regulatory tfbs in PIK3CA promoter
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     RT2 qPCR Primer Assay in human, mouse, rat PIK3CA
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     SABiosciences PCR Arrays including human, mouse, rat PIK3CA
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     Browse Sino Biological Proteins and Antibodies
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     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
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     Drugs/Proteins for PIK3CA
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PIK3CA antibodies
     PIK3CA proteins
     PIK3CA lysates
     Antibodies for PIK3CA
     See all of Abcam's Antibodies, Kits and Proteins for PIK3CA
     Custom Antibody / Protein Production Service
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     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for PIK3CA
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
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     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3CA
     SwitchGear 3'UTR luciferase reporter plasmids for PIK3CA
     SwitchGear Promoter luciferase reporter plasmids for PIK3CA
     ThermoFisher Antibody for PIK3CA
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3CA
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PIK3CA
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PIK3CA
     Validated adenovirus to knockdown PIK3CA in human, mouse

    Customized:
     lentivirus for stable overexpression of PIK3CA
     lentivirus expression plasmids for stable overexpression of PIK3CA
     adenovirus for overexpression of PIK3CA
     LSBio Antibodies in human, mouse, rat for PIK3CA
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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