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PIK3C2G Gene

protein-coding   GIFtS: 62
GCID: GC12P018414

Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit...

(Previous names: phosphoinositide-3-kinase, class 2, gamma polypeptide)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2
Gamma1 2
     Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit
Gamma2
Phosphoinositide-3-Kinase, Class 2, Gamma Polypeptide1 2     Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing Gamma
Polypeptide2
PtdIns-3-Kinase C2 Subunit Gamma2 3     Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing Subunit
Gamma2
PI3K-C2-gamma2 3     PTDINS-3-Kinase C2 Gamma2
EC 2.7.1.1543 8     Phosphoinositide 3-Kinase-C2-Gamma3
PI3K-C2GAMMA2     EC 2.7.18

External Ids:    HGNC: 89731   Entrez Gene: 52882   Ensembl: ENSG000001391447   OMIM: 6090015   UniProtKB: O757473   

Export aliases for PIK3C2G gene to outside databases

Previous GC identifers: GC12P018154 GC12P018559 GC12P018314 GC12P018305


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PIK3C2G Gene:
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in
signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and
intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal
C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding
motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions.
This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, Jan 2014)

GeneCards Summary for PIK3C2G Gene:
PIK3C2G (phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma) is a protein-coding gene. Diseases associated with PIK3C2G include kaposi's sarcoma, and hiv-1. GO annotations related to this gene include 1-phosphatidylinositol-4-phosphate 3-kinase activity and phosphatidylinositol binding. An important paralog of this gene is PIK3C2B.

UniProtKB/Swiss-Prot: P3C2G_HUMAN, O75747
Function: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate
(PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity)

summary for PIK3C2G Gene:
PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the
3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of
cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell
migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric
consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and
delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst
p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have
recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes
(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI
3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to
play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3C2G Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PIK3C2G gene promoter:
         C/EBPbeta   Nkx5-1   NF-AT   AREB6   NF-AT4   POU2F1   NF-AT2   POU2F1a   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIK3C2G promoter sequence
   Search Chromatin IP Primers for PIK3C2G

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIK3C2G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p12

PIK3C2G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIK3C2G gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P018414:  view genomic region     (about GC identifiers)

Start:
18,400,548 bp from pter      End:
18,801,352 bp from pter
Size:
400,805 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: P3C2G_HUMAN, O75747 (See protein sequence)
Recommended Name: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma  
Size: 1445 amino acids; 165715 Da
Sequence caution: Sequence=CAA03853.1; Type=Erroneous termination; Positions=1446; Note=Translated as stop;
1 PDB 3D structure from and Proteopedia for PIK3C2G:
2WWE (3D)    
Secondary accessions: A1L3U0

Explore the universe of human proteins at neXtProt for PIK3C2G: NX_O75747

Explore proteomics data for PIK3C2G at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for PIK3C2G (O75747)
     KRDRAPF  DLRQDML  DRHNDNIM  CDRHNDNIML 


    See PIK3C2G Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001275701.1  NP_001275703.1  NP_004561.3  

    ENSEMBL proteins: 
     ENSP00000443850   ENSP00000441618   ENSP00000266497   ENSP00000404845   ENSP00000445381  
    Reactome Protein details: O75747

    PIK3C2G Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
    Phosphatidylinositol-4-phosphate 3-kinase family

    Selected InterPro protein domains (see all 10):
     IPR001263 PInositide-3_kin_accessory_dom
     IPR002420 PI3K_C2_dom
     IPR001683 Phox
     IPR011009 Kinase-like_dom
     IPR000403 PI3/4_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry O75747

    ProtoNet protein and cluster: O75747

    4 Blocks protein domains:
    IPB000008 C2 domain
    IPB000341 Phosphoinositide 3-kinase
    IPB000403 Phosphatidylinositol 3- and 4-kinase
    IPB001683 Phox-like


    UniProtKB/Swiss-Prot: P3C2G_HUMAN, O75747
    Similarity: Belongs to the PI3/PI4-kinase family
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 C2 PI3K-type domain
    Similarity: Contains 1 PI3K-RBD domain
    Similarity: Contains 1 PI3K/PI4K domain
    Similarity: Contains 1 PIK helical domain
    Similarity: Contains 1 PX (phox homology) domain


    PIK3C2G for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P3C2G_HUMAN, O75747
    Function: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate
    (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity)
    Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol
    3,4-bisphosphate

         Genatlas biochemistry entry for PIK3C2G:
    phosphatidylinositol 3-kinase class 2,gamma polypeptide,expressed in normal breast,liver,prostate and other
    tissues

         Enzyme Numbers (IUBMB): EC 2.7.1.1541 2 EC 2.7.12

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
    GO:00163031-phosphatidylinositol-3-kinase activity NAS9878262
         
    PIK3C2G for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PIK3C2G:
     Decreased CYP1A1 activity afte  Decreased focal adhesion (FA)   Decreased influenza A/WSN/33 r  Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PIK3C2G
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PIK3C2G
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PIK3C2G

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    5 qRT-PCR Assays for microRNAs that regulate PIK3C2G:
    hsa-miR-569 hsa-miR-183* hsa-miR-1244 hsa-miR-29a* hsa-miR-548u
    SwitchGear 3'UTR luciferase reporter plasmidPIK3C2G 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PIK3C2G

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3C2G


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    P3C2G_HUMAN, O75747: Membrane; Peripheral membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    plasma membrane3
    nucleus2
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IBA--
    GO:0005942phosphatidylinositol 3-kinase complex IBA--

    PIK3C2G for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PIK3C2G About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1PI Metabolism
    PI Metabolism0.65
    3-phosphoinositide biosynthesis0.47
    Synthesis of PIPs at the plasma membrane0.65
    Synthesis of PIPs at the Golgi membrane0.00
    2Inositol phosphate metabolism (KEGG)
    Inositol phosphate metabolism0.61
    superpathway of inositol phosphate compounds0.60
    Phosphatidylinositol signaling system0.61
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    4Apoptosis Pathway
    Apoptosis Pathway0.45
    Akt Pathway0.39
    NF-kappaB Pathway0.45
    5mTOR Pathway
    mTOR Pathway0.38
    Insulin Pathway0.32
    TGF-beta Pathway0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PIK3C2G
        Molecular Mechanisms of Cancer
    ICos-ICosL Pathway in T-Helper Cell
    PI3K Signaling in B-Lymphocyte
    CD28 Signaling in T-Helper Cell

    Selected Tocris Bioscience Pathways for PIK3C2G (see all 9)
        Akt Pathway
    Insulin Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    Toll-like Receptor Pathway

    5 BioSystems Pathways for PIK3C2G
        Insulin Signaling
    Signaling Pathways in Glioblastoma
    Regulation of Actin Cytoskeleton
    3-phosphoinositide biosynthesis
    superpathway of inositol phosphate compounds

    2 Reactome Pathways for PIK3C2G
        Synthesis of PIPs at the plasma membrane
    Synthesis of PIPs at the Golgi membrane


    3 Kegg Pathways  (Kegg details for PIK3C2G):
        Inositol phosphate metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system


    PIK3C2G for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PIK3C2G
    Interactions:

        GeneGlobe Interaction Network for PIK3C2G

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PIK3C2G (ENSP000004048454) via UniProtKB, MINT, STRING, and/or I2D (see all 99)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INPP4AENSP000000743044STRING: ENSP00000074304
    INPP4BENSP000002629924STRING: ENSP00000262992
    PI4KAENSP000002558824STRING: ENSP00000255882
    PI4KBENSP000002716574STRING: ENSP00000271657
    INPP5BENSP000003621154STRING: ENSP00000362115
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0006935chemotaxis IEA--
    GO:0008150biological_process ND--
    GO:0036092phosphatidylinositol-3-phosphate biosynthetic process NAS9878262

    PIK3C2G for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for PIK3C2G available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CZC 24832Selective inhibitor of PI 3-Kinase gamma[1159824-67-5]
    QuercetinNon-selective PI 3-kinase inhibitor[117-39-5]
    PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK [371935-74-9]
    AS 605240Potent and selective PI 3-kinase gamma (PI3Kgamma) inhibitor[648450-29-7]
    740 Y-PCell-permeable PI 3-kinase activator[1236188-16-1]

    2 HMDB Compounds for PIK3C2G    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PIK3C2G gene (3 alternative transcripts): 
    NM_001288772.1  NM_001288774.1  NM_004570.5  

    Unigene Cluster for PIK3C2G:

    Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
    Hs.22500  [show with all ESTs]
    Unigene Representative Sequence: AJ000008
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000535651 ENST00000546003 ENST00000266497 ENST00000536967 ENST00000538458
    ENST00000433979(uc001rdt.3 uc010sia.2 uc010sib.2 uc010sic.2)
    ENST00000538779
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AJ000008.1 BC130277.1 BC144133.1 BC144134.1 

    2 DOTS entries:

    DT.442133  DT.102824490 

    Selected AceView cDNA sequences (see all 33):

    BX092808 R43405 AL699201 AA906464 NM_004570 AA970382 CD618956 CD618954 
    BG207636 BG186950 AI005414 BU687433 AA724283 AJ000008 AI024088 AI808155 
    AI373752 AI478164 AI796188 AA970381 BG187979 BG213406 AA382965 CD618959 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PIK3C2G expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PIK3C2G Expression
    About this image


    PIK3C2G expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Granulosa Cells Primary Follicle
    PIK3C2G Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIK3C2G Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.22500

    UniProtKB/Swiss-Prot: P3C2G_HUMAN, O75747
    Tissue specificity: Highly expressed in liver, prostate and testis. Lower levels in small intestine, kidney and
    pancreas

        Custom PCR Arrays for PIK3C2G
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3C2G

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PIK3C2G gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pik3c2g1 , 5 phosphatidylinositol 3-kinase, C2 domain containing, more1, 5 79.88(n)1
    73.28(a)1
      6 (69.70 cM)5
    187051  NM_207683.21  NP_997566.11 
     1396140725 
    chicken
    (Gallus gallus)
    Aves PIK3C2G1 phosphoinositide-3-kinase, class 2, gamma polypeptide 66.49(n)
    57.89(a)
      418181  XM_416412.4  XP_416412.4 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003305141 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing more 47.95(n)
    40.86(a)
      100330514  XM_002665428.3  XP_002665474.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pi3K68D6
    Phosphotidylinositol 3 kinase 68D
    21(a)
    1 → many
    3L(11767750-11783113)
    worm
    (Caenorhabditis elegans)
    Secernentea piki-16
    Protein PIKI-1 (piki-1) mRNA, complete cds
    21(a)
    1 → many
    X(15234832-15246365) WBGene00009552
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS346
    Phosphatidylinositol 3-kinase responsible for the ...
    20(a)
    1 → many
    XII(617533-620160) YLR240W


    ENSEMBL Gene Tree for PIK3C2G (if available)
    TreeFam Gene Tree for PIK3C2G (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PIK3C2G gene
    PIK3C2B2  PIK3CD2  PIK3CA2  PIK3CG2  PIK3C32  PIK3CB2  PIK3C2A2  
    9 SIMAP similar genes for PIK3C2G using alignment to 5 protein entries:     P3C2G_HUMAN (see all proteins):
    DKFZp686G16234    PIK3CB    PIK3CG    PIK3C3    PIK3C2B variant protein    DKFZp779K1237
    PIK3C2B    PIK3C2A    PI4KB

    PIK3C2G for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PIK3C2G (see all 7688)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38138981,2
    C--18412483(-) CCACTC/GTAAAG 1 -- us2k10--------
    rs1163762401,2
    F--18412494(+) GGGGAA/CATAAG 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs38138971,2
    C,F,A,H--18412607(-) TAAGAT/GTCAAA 1 -- us2k117Minor allele frequency- G:0.48NA NS EA WA CSA 923
    rs38413691,2
    C--18412683(-) TTTACA/-GTGCA 1 -- us2k11Minor allele frequency- -:0.00CSA 2
    rs725257971,2
    C--18412683(+) TGCAC-/TCGTAA 1 -- us2k10--------
    rs668471471,2
    C--18412684(+) GCACG-/TTAAAC 1 -- us2k10--------
    rs42379731,2
    C,F,A,H--18412764(+) AAAAAC/TGGAGT 1 -- us2k111Minor allele frequency- T:0.50NA WA CSA EA 509
    rs42671191,2
    C,F,A--18412858(+) AGAAGC/TTTAAT 1 -- us2k1 tfbs39Minor allele frequency- T:0.29NA WA EA 500
    rs110439841,2
    C--18412865(+) TAATTG/ATTCTC 1 -- us2k1 tfbs33Minor allele frequency- A:0.28CSA NA EA 241
    rs1506691361,2
    C--18412912(+) TAAGC-/GTGTACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PIK3C2G (18400548 - 18650548 bp, first 250kb of PIK3C2G)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PIK3C2G (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745610CNV Deletion23290073
    esv2745612CNV Deletion23290073
    esv2674487CNV Deletion23128226
    esv2672387CNV Deletion23128226
    esv2745611CNV Deletion23290073
    esv2650294CNV Deletion19546169
    esv1542857CNV Deletion17803354
    esv267505CNV Insertion20981092
    esv268773CNV Insertion20981092
    esv1370525CNV Insertion17803354

    Human Gene Mutation Database (HGMD): PIK3C2G
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PIK3C2G
    DNA2.0 Custom Variant and Variant Library Synthesis for PIK3C2G

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609001    OMIM disorders: --

    8 diseases for PIK3C2G:    
    About MalaCards
    kaposi's sarcoma    hiv-1    sarcoma    schizophrenia
    prostate cancer    prostatitis    endotheliitis    neuronitis


    PIK3C2G for disorders           About GeneDecksing

    Genetic Association Database (GAD): PIK3C2G
    Human Genome Epidemiology (HuGE) Navigator: PIK3C2G (5 documents)

    Export disorders for PIK3C2G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIK3C2G gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with PIK3C2G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12. (PubMed id 9878262)1, 2, 3, 9 Rozycka M.... Fry M.J. (Genomics 1998)
    2. Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population. (PubMed id 17991425)1, 2, 4 Daimon M.... Kato T. (Biochem. Biophys. Res. Commun. 2008)
    3. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    4. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PubMed id 18996102)1, 4 RuaA+o G....Hanks S. ( international journal of clinical chemistry 2009)
    5. An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia. (PubMed id 17893707)1, 4 Jungerius B.J....Sinke R.J. (Mol. Psychiatry 2008)
    6. Genome-wide association analysis with gray matter volume as a quantitative phenotype in first-episode treatment-naA^ve patients with schizophrenia. (PubMed id 24086445)1 Wang Q....Li T. (PLoS ONE 2013)
    7. Akt/Nox2/NF-I_B signaling pathway is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation. (PubMed id 21029719)1 Zhang H.S....Wang Y.O. (Arch. Biochem. Biophys. 2011)
    8. Genetic copy number variants in myocardial infarction patients with hyperlipidemia. (PubMed id 22369086)1 Shia W.C....Hsu F.R. (BMC Genomics 2011)
    9. Integrated analysis of mutations, miRNA and mRNA expression in glioblastoma. (PubMed id 21114830)1 Dong H....Xiong M. (BMC Syst Biol 2010)
    10. Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders. (PubMed id 20818790)1 Kang Y.J....Lipton S.A. (Ann. Neurol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5288 HGNC: 8973 AceView: PIK3C2G Ensembl:ENSG00000139144 euGenes: HUgn5288
    ECgene: PIK3C2G Kegg: 5288 H-InvDB: PIK3C2G

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PIK3C2G Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PIK3C2G Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PIK3C2G gene:
    Search GeneIP for patents involving PIK3C2G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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