Aliases for PIK3C2G Gene
- Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 Gamma 2 3
- Phosphoinositide-3-Kinase, Class 2, Gamma Polypeptide 2 3
- PtdIns-3-Kinase C2 Subunit Gamma 3 4
- PI3K-C2-Gamma 3 4
- EC 188.8.131.52 4 64
- Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing Gamma Polypeptide 3
- Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit Gamma 3
External Ids for PIK3C2G Gene
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
GeneCards Summary for PIK3C2G Gene
PIK3C2G (Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 Gamma) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and ERK Signaling. GO annotations related to this gene include phosphatidylinositol binding and 1-phosphatidylinositol-4-phosphate 3-kinase activity. An important paralog of this gene is PIK3CB.
UniProtKB/Swiss-Prot for PIK3C2G Gene
Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity).
PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the 3OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes (C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI 3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.