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Aliases for PIK3C2G Gene

Aliases for PIK3C2G Gene

  • Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 Gamma 2 3
  • Phosphoinositide-3-Kinase, Class 2, Gamma Polypeptide 2 3
  • PtdIns-3-Kinase C2 Subunit Gamma 3 4
  • PI3K-C2-Gamma 3 4
  • EC 2.7.1.154 4 63
  • Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing Gamma Polypeptide 3
  • Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing Subunit Gamma 3
  • Phosphoinositide 3-Kinase-C2-Gamma 4
  • PTDINS-3-Kinase C2 Gamma 3
  • PI3K-C2GAMMA 3
  • EC 2.7.1 63

External Ids for PIK3C2G Gene

Previous GeneCards Identifiers for PIK3C2G Gene

  • GC12P018154
  • GC12P018559
  • GC12P018314
  • GC12P018305
  • GC12P018414

Summaries for PIK3C2G Gene

Entrez Gene Summary for PIK3C2G Gene

  • The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for PIK3C2G Gene

PIK3C2G (Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 Gamma) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and ERK Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and kinase activity. An important paralog of this gene is PIK3CB.

UniProtKB/Swiss-Prot for PIK3C2G Gene

  • Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity).

Tocris Summary for PIK3C2G Gene

  • PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.

Gene Wiki entry for PIK3C2G Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIK3C2G Gene

Genomics for PIK3C2G Gene

Regulatory Elements for PIK3C2G Gene

Genomic Location for PIK3C2G Gene

Chromosome:
12
Start:
18,242,965 bp from pter
End:
18,699,660 bp from pter
Size:
456,696 bases
Orientation:
Plus strand

Genomic View for PIK3C2G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIK3C2G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIK3C2G Gene

Proteins for PIK3C2G Gene

  • Protein details for PIK3C2G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75747-P3C2G_HUMAN
    Recommended name:
    Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
    Protein Accession:
    O75747
    Secondary Accessions:
    • A1L3U0

    Protein attributes for PIK3C2G Gene

    Size:
    1445 amino acids
    Molecular mass:
    165715 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA03853.1; Type=Erroneous termination; Positions=1446; Note=Translated as stop.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PIK3C2G Gene

neXtProt entry for PIK3C2G Gene

Proteomics data for PIK3C2G Gene at MOPED

Selected DME Specific Peptides for PIK3C2G Gene

Post-translational modifications for PIK3C2G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIK3C2G Gene

Antibody Products

Domains & Families for PIK3C2G Gene

Suggested Antigen Peptide Sequences for PIK3C2G Gene

Graphical View of Domain Structure for InterPro Entry

O75747

UniProtKB/Swiss-Prot:

P3C2G_HUMAN :
  • Contains 1 C2 domain.
  • Belongs to the PI3/PI4-kinase family.
Domain:
  • Contains 1 C2 domain.
  • Contains 1 C2 PI3K-type domain.
  • Contains 1 PI3K-RBD domain.
  • Contains 1 PI3K/PI4K domain.
  • Contains 1 PIK helical domain.
  • Contains 1 PX (phox homology) domain.
Family:
  • Belongs to the PI3/PI4-kinase family.
genes like me logo Genes that share domains with PIK3C2G: view

Function for PIK3C2G Gene

Molecular function for PIK3C2G Gene

GENATLAS Biochemistry:
phosphatidylinositol 3-kinase class 2,gamma polypeptide,expressed in normal breast,liver,prostate and other tissues
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
UniProtKB/Swiss-Prot Function:
Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity).

Enzyme Numbers (IUBMB) for PIK3C2G Gene

Gene Ontology (GO) - Molecular Function for PIK3C2G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0016303 1-phosphatidylinositol-3-kinase activity NAS 9878262
GO:0016307 phosphatidylinositol phosphate kinase activity NAS 9878262
genes like me logo Genes that share ontologies with PIK3C2G: view
genes like me logo Genes that share phenotypes with PIK3C2G: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIK3C2G

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PIK3C2G Gene

Localization for PIK3C2G Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIK3C2G Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIK3C2G Gene COMPARTMENTS Subcellular localization image for PIK3C2G gene
Compartment Confidence
cytosol 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for PIK3C2G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IBA --
GO:0005942 phosphatidylinositol 3-kinase complex IBA --
genes like me logo Genes that share ontologies with PIK3C2G: view

Pathways & Interactions for PIK3C2G Gene

genes like me logo Genes that share pathways with PIK3C2G: view

Interacting Proteins for PIK3C2G Gene

Gene Ontology (GO) - Biological Process for PIK3C2G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0006468 protein phosphorylation IBA --
GO:0006644 phospholipid metabolic process TAS --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0006954 inflammatory response IBA --
genes like me logo Genes that share ontologies with PIK3C2G: view

No data available for SIGNOR curated interactions for PIK3C2G Gene

Drugs & Compounds for PIK3C2G Gene

(20) Drugs for PIK3C2G Gene - From: DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
3-Methyladenine Experimental Pharma Class III PI3K inhibitor, Class III PI 3-kinase inhibitor; also inhibits autophagy 0
SF1126 Investigational Pharma inhibitor Kinase Inhibitors 0
XL147 Investigational Pharma inhibitor PI3K inhibitor,selective and reversible, Kinase Inhibitors, Phosphatidylinositol-3- kinase (PI-3K) inhibitors 0
BAY80-6946 Pharma Inhibition, Biomarker, inhibitor PI3K Inhibitors, Kinase Inhibitors 0

(4) Additional Compounds for PIK3C2G Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
ETP 45658
1198357-79-7
iMDK
881970-80-5
PI 103 hydrochloride
371935-79-4
genes like me logo Genes that share compounds with PIK3C2G: view

Transcripts for PIK3C2G Gene

Unigene Clusters for PIK3C2G Gene

Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIK3C2G

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIK3C2G Gene

No ASD Table

Relevant External Links for PIK3C2G Gene

GeneLoc Exon Structure for
PIK3C2G
ECgene alternative splicing isoforms for
PIK3C2G

Expression for PIK3C2G Gene

mRNA expression in normal human tissues for PIK3C2G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIK3C2G Gene

This gene is overexpressed in Stomach (x16.5), Liver (x8.7), Skin - Not Sun Exposed (Suprapubic) (x6.9), Skin - Sun Exposed (Lower leg) (x6.2), and Breast - Mammary Tissue (x4.2).

Protein differential expression in normal tissues from HIPED for PIK3C2G Gene

This gene is overexpressed in Plasma (59.2) and Breast (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PIK3C2G Gene



SOURCE GeneReport for Unigene cluster for PIK3C2G Gene Hs.22500

mRNA Expression by UniProt/SwissProt for PIK3C2G Gene

O75747-P3C2G_HUMAN
Tissue specificity: Highly expressed in liver, prostate and testis. Lower levels in small intestine, kidney and pancreas.
genes like me logo Genes that share expression patterns with PIK3C2G: view

Protein tissue co-expression partners for PIK3C2G Gene

Primer Products

In Situ Assay Products

Orthologs for PIK3C2G Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIK3C2G Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PIK3C2G 35
  • 87.58 (n)
  • 84.14 (a)
PIK3C2G 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIK3C2G 35
  • 88.94 (n)
  • 85.13 (a)
PIK3C2G 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pik3c2g 35
  • 79.88 (n)
  • 73.28 (a)
Pik3c2g 16
Pik3c2g 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PIK3C2G 35
  • 98.45 (n)
  • 97.43 (a)
PIK3C2G 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pik3c2g 35
  • 78.65 (n)
  • 72.19 (a)
chicken
(Gallus gallus)
Aves PIK3C2G 35
  • 66.49 (n)
  • 57.89 (a)
PIK3C2G 36
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100330514 35
  • 47.95 (n)
  • 40.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pi3K68D 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea piki-1 36
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS34 36
  • 20 (a)
OneToMany
Species with no ortholog for PIK3C2G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PIK3C2G Gene

ENSEMBL:
Gene Tree for PIK3C2G (if available)
TreeFam:
Gene Tree for PIK3C2G (if available)

Paralogs for PIK3C2G Gene

Paralogs for PIK3C2G Gene

genes like me logo Genes that share paralogs with PIK3C2G: view

Variants for PIK3C2G Gene

Sequence variations from dbSNP and Humsavar for PIK3C2G Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs475137 -- 18,633,172(+) atatt(C/T)cattg intron-variant
rs588685 -- 18,633,517(+) cttca(A/T)gacgg intron-variant
rs589047 -- 18,633,557(+) tggtc(A/G)ttgta intron-variant
rs606257 -- 18,635,114(+) GGGAT(A/G)TCCCA intron-variant
rs617336 -- 18,635,295(+) caatg(C/G)aaacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIK3C2G Gene

Variant ID Type Subtype PubMed ID
nsv898837 CNV Gain 21882294
nsv832343 CNV Gain 17160897
nsv832344 CNV Loss 17160897
nsv898846 CNV Loss 21882294
nsv898847 CNV Loss 21882294
nsv627 CNV Loss 18451855
nsv438194 CNV Loss 16468122
esv2674487 CNV Deletion 23128226
esv2650294 CNV Deletion 19546169
esv2745610 CNV Deletion 23290073
esv2745611 CNV Deletion 23290073
esv2745612 CNV Deletion 23290073
esv1542857 CNV Deletion 17803354
nsv8926 CNV Loss 18304495
nsv437727 CNV Loss 16327808
nsv437728 CNV Loss 16327808
esv267505 CNV Insertion 20981092
esv274546 CNV Insertion 20981092
esv268773 CNV Insertion 20981092
esv23982 CNV Loss 19812545
esv2672387 CNV Deletion 23128226
esv1370525 CNV Insertion 17803354
nsv520574 CNV Loss 19592680
nsv521707 CNV Loss 19592680
nsv628 CNV Insertion 18451855

Variation tolerance for PIK3C2G Gene

Residual Variation Intolerance Score: 98.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.61; 98.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIK3C2G Gene

HapMap Linkage Disequilibrium report
PIK3C2G
Human Gene Mutation Database (HGMD)
PIK3C2G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIK3C2G Gene

Disorders for PIK3C2G Gene

Relevant External Links for PIK3C2G

Genetic Association Database (GAD)
PIK3C2G
Human Genome Epidemiology (HuGE) Navigator
PIK3C2G
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIK3C2G
genes like me logo Genes that share disorders with PIK3C2G: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIK3C2G Gene

Publications for PIK3C2G Gene

  1. cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12. (PMID: 9878262) Rozycka M. … Fry M.J. (Genomics 1998) 2 23 67
  2. Development of first lead structures for phosphoinositide 3-kinase-C2I^ inhibitors. (PMID: 24983663) Freitag A. … Laufer S.A. (J. Med. Chem. 2015) 67
  3. HIV-1 Tat protein induces the production of IDO in human monocyte derived-dendritic cells through a direct mechanism: effect on T cells proliferation. (PMID: 24073214) PlanA"s R. … Bahraoui E. (PLoS ONE 2013) 67
  4. HIV-1 Tat promotes Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6-induced angiogenesis and tumorigenesis by regulating PI3K/PTEN/AKT/GSK-3I^ signaling pathway. (PMID: 23301033) Zhou F. … Lu C. (PLoS ONE 2013) 67
  5. Genome-wide association analysis with gray matter volume as a quantitative phenotype in first-episode treatment-naA^ve patients with schizophrenia. (PMID: 24086445) Wang Q. … Li T. (PLoS ONE 2013) 67

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