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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PIK3C2G Gene

protein-coding   GIFtS: 62
GCID: GC12P018414

phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit...

(Previous names: phosphoinositide-3-kinase, class 2, gamma polypeptide )
 Explore 8 diseases affiliated with
PIK3C2G via
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 Human Malady Compendium 
Biological research products
for PIK3C2G    

Aliases
for PIK3C2G gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2
Gamma1 2
     Phosphatidylinositol 3-Kinase C2 Domain-Containing Gamma2
Phosphoinositide-3-Kinase, Class 2, Gamma Polypeptide1 2     Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit Gamma2
Phosphoinositide 3-Kinase-C2-Gamma2 3     Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing Gamma
Polypeptide2
PtdIns-3-Kinase C2 Subunit Gamma2 3     Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing Subunit Gamma2
PI3K-C2-Gamma1     PTDINS-3-Kinase C2 Gamma2
EC 2.7.1.1543 8     EC 2.7.18
PI3K-C2GAMMA2     

External Ids:    HGNC: 89731   Entrez Gene: 52882   Ensembl: ENSG000001391447   OMIM: 6090015   UniProtKB: O757473   

Export aliases for PIK3C2G gene to outside databases

Previous GC identifers: GC12P018154 GC12P018559 GC12P018314 GC12P018305


Summaries
for PIK3C2G gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PIK3C2G:
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in
signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and
intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2
domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that
mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The biological
function of this gene has not yet been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: P3C2G_HUMAN, O75747
Function: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate
(PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity)

summary for PIK3C2G:
PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the
3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of
cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell
migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric
consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and
delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst
p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have
recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes
(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI
3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to
play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3C2G


Genomic Views
for PIK3C2G gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PIK3C2G gene promoter:
         C/EBPbeta   Nkx5-1   NF-AT   AREB6   NF-AT4   POU2F1   NF-AT2   POU2F1a   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PIK3C2G promoter sequence
   Search SABiosciences Chromatin IP Primers for PIK3C2G

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIK3C2G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p12

PIK3C2G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIK3C2G gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P018414:  view genomic region     (about GC identifiers)

Start:
 18,400,548 bp from pter      End:
 18,801,352 bp from pter
Size:
 400,805 bases      Orientation:
 plus strand

Proteins
for PIK3C2G gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: P3C2G_HUMAN, O75747 (See protein sequence)
Recommended Name: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma  
Size: 1445 amino acids; 165715 Da
Subcellular location: Membrane; Peripheral membrane protein (By similarity)
Sequence caution: Sequence=CAA03853.1; Type=Erroneous termination; Positions=1446; Note=Translated as stop;
1 PDB 3D structure from and Proteopedia for PIK3C2G:
2WWE (3D)    
Secondary accessions: A1L3U0

Explore the universe of human proteins at neXtProt for PIK3C2G: NX_O75747

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75747

    • 4 DME Specific Peptides for PIK3C2G (O75747)
     KRDRAPF  DLRQDML  DRHNDNIM  CDRHNDNIML 

    PIK3C2G Protein expression data from MOPED and PaxDb:    About this image 
    PIK3C2G Protein Expression
    REFSEQ proteins: NP_004561.3  
    ENSEMBL proteins: 
     ENSP00000443850   ENSP00000441618   ENSP00000266497   ENSP00000404845   ENSP00000445381  
    Reactome Protein details: O75747
    Human Recombinant Protein Products for PIK3C2G: 
    EMD Millipore Purified and/or Recombinant PIK3C2G Protein
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    Novus Biologicals PIK3C2G Protein
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope ----
    GO:0005794Golgi apparatus ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane ----
    GO:0016020membrane IEA--

    PIK3C2G for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for PIK3C2G gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PIK3C2G for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR001263 PInositide-3_kin_accessory_dom
     IPR002420 PI3K_C2_dom
     IPR001683 Phox
     IPR011009 Kinase-like_dom
     IPR000403 PI3/4_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry O75747

    ProtoNet protein and cluster: O75747

    4 Blocks protein families:
    IPB000008 C2 domain
    IPB000341 Phosphoinositide 3-kinase
    IPB000403 Phosphatidylinositol 3- and 4-kinase
    IPB001683 Phox-like


    UniProtKB/Swiss-Prot: P3C2G_HUMAN, O75747
    Similarity: Belongs to the PI3/PI4-kinase family
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 C2 PI3K-type domain
    Similarity: Contains 1 PI3K-RBD domain
    Similarity: Contains 1 PI3K/PI4K domain
    Similarity: Contains 1 PIK helical domain
    Similarity: Contains 1 PX (phox homology) domain


    Function
    for PIK3C2G gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P3C2G_HUMAN, O75747
    Function: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate
    (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity)
    Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol
    3,4-bisphosphate

         Genatlas biochemistry entry for PIK3C2G:
    phosphatidylinositol 3-kinase class 2,gamma polypeptide,expressed in normal breast,liver,prostate and other tissues

         Enzyme Numbers (IUBMB): EC 2.7.1.1541 2 EC 2.7.12

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
    GO:00163031-phosphatidylinositol-3-kinase activity NAS9878262
    GO:0016307phosphatidylinositol phosphate kinase activity NAS9878262
    GO:0016773phosphotransferase activity, alcohol group as acceptor ----
         
    PIK3C2G for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PIK3C2G:
     Decreased CYP1A1 activity afte  Decreased focal adhesion (FA)   Decreased influenza A/WSN/33 r  Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PIK3C2G 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: PIK3C2G
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIK3C2G
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate PIK3C2G:
    hsa-miR-569 hsa-miR-183* hsa-miR-1244 hsa-miR-29a* hsa-miR-548u
    SwitchGear 3'UTR luciferase reporter plasmid: PIK3C2G 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PIK3C2G (see all 7)
    OriGene shRNA RFP: PIK3C2G
    OriGene siRNA: PIK3C2G
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIK3C2G
    Sirion Biotech Custom design and validation of potent shRNA sequences against PIK3C2G 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of PIK3C2G 
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3C2G


    Pathways & Interactions
    for PIK3C2G gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mTOR Pathway
    		mTOR Pathway1.00
    		Insulin Pathway0.32
    		TGF-beta Pathway0.38
    2PI Metabolism
    		PI Metabolism1.00
    		3-phosphoinositide biosynthesis0.48
    		Synthesis of PIPs at the plasma membrane0.66
    3Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    		Metabolic pathways0.38
    4Apoptosis Pathway
    		Apoptosis Pathway1.00
    		Akt Pathway0.39
    		NF-kappaB Pathway0.45
    5Inositol phosphate metabolism
    		Inositol phosphate metabolism1.00
    		Phosphatidylinositol signaling system0.59
    		superpathway of inositol phosphate compounds0.59

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PIK3C2G
        Molecular Mechanisms of Cancer
    ICos-ICosL Pathway in T-Helper Cell
    PI3K Signaling in B-Lymphocyte
    CD28 Signaling in T-Helper Cell

    5/9 Tocris Bioscience Pathways for PIK3C2G (see all 9)
        Akt Pathway
    Insulin Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    Toll-like Receptor Pathway

    5 BioSystems Pathways for PIK3C2G 
        Signaling Pathways in Glioblastoma
    3-phosphoinositide biosynthesis
    Regulation of Actin Cytoskeleton
    Insulin Signaling
    superpathway of inositol phosphate compounds

    5/6        Reactome Pathways for PIK3C2G (see all 6)
        Metabolism
    Synthesis of PIPs at the plasma membrane
    Phospholipid metabolism
    Metabolism of lipids and lipoproteins
    PI Metabolism


    3         Kegg Pathways  (Kegg details for PIK3C2G):
        Inositol phosphate metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system


    PIK3C2G for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIK3C2G

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/30 Interacting proteins for PIK3C2G (ENSP000004048454) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PI4K2AENSP000003596654STRING: ENSP00000359665
    PI4K2BENSP000002648644STRING: ENSP00000264864
    PI4KAENSP000002558824STRING: ENSP00000255882
    PI4KBENSP000002716574STRING: ENSP00000271657
    PIP5K1BENSP000002653824STRING: ENSP00000265382
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0006935chemotaxis IEA--
    GO:0008150biological_process ND--
    GO:0036092phosphatidylinositol-3-phosphate biosynthetic process NAS9878262

    PIK3C2G for ontologies           About GeneDecksing



    Drugs & Compounds
    for PIK3C2G gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for PIK3C2G:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PIK3C2G available from Tocris Bioscience    About this table
    CompoundAction CAS #
    LY 294002 hydrochlorideSelective PI 3-kinase inhibitor[154447-36-6]
    QuercetinNon-selective PI 3-kinase inhibitor[117-39-5]
    PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK [371935-74-9]
    Wortmannin Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 [19545-26-7]
    PI 828 PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130) [942289-87-4]

    2 HMDB Compounds for PIK3C2G    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Search CenterWatch for drugs/clinical trials and news about PIK3C2G / P3C2G 

    Transcripts
    for PIK3C2G gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PIK3C2G gene: 
    NM_004570.4  

    Unigene Cluster for PIK3C2G:

    Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
    Hs.22500  [show with all ESTs]
    Unigene Representative Sequence: AJ000008
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000535651 ENST00000546003 ENST00000266497 ENST00000536967 ENST00000538458
    ENST00000433979(uc001rdt.3 uc010sia.2 uc010sib.2 uc010sic.2)
    ENST00000538779

    miRNA
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    hsa-miR-569 hsa-miR-183* hsa-miR-1244 hsa-miR-29a* hsa-miR-548u
    SwitchGear 3'UTR luciferase reporter plasmid: PIK3C2G 3' UTR sequence
    Inhib. RNA
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3C2G 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIK3C2G
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIK3C2G

    Additional cDNA sequence: 

    AJ000008.1 BC130277.1 BC144133.1 BC144134.1 

    2 DOTS entries:

    DT.442133  DT.102824490 

    24/33 AceView cDNA sequences (see all 33):

    BX092808 AA906464 R43405 AL699201 CD618954 NM_004570 CD618956 BG187979 
    AI478164 AI005414 AI808155 AA970382 BU687433 AJ000008 AI373752 AA724283 
    BG186950 AI024088 AA970381 BG207636 AI796188 AA382965 AW195485 CD618959 

    GeneLoc Exon Structure


    Expression
    for PIK3C2G gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PIK3C2G expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    PIK3C2G Expression
    About this image

    PIK3C2G expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleCumulus CellsOvary
    OvaryPrimary FollicleGranulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

    See PIK3C2G Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PIK3C2G

    SOURCE GeneReport for Unigene cluster: Hs.22500

    UniProtKB/Swiss-Prot: P3C2G_HUMAN, O75747
    Tissue specificity: Highly expressed in liver, prostate and testis. Lower levels in small intestine, kidney and
    pancreas

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    Orthologs
    for PIK3C2G gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PIK3C2G gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Pik3c2g1 , 5 phosphatidylinositol 3-kinase, C2 domain containing, more1, 5 79.88(n)1
    73.29(a)1    		   6 (69.70 cM)5
    187051  NM_207683.21  NP_997566.11 
     1396140725 
    chicken
    (Gallus gallus)    		 Aves PIK3C2G1 phosphoinositide-3-kinase, class 2, gamma polypeptide 66.62(n)
    58.25(a)    		   418181  XM_416412.3  XP_416412.3 
    worm
    (Caenorhabditis elegans)    		 Secernentea piki-16
    		 --
    		 12(a)
    		 1 → many
    		 X(15234763-15246296)


    ENSEMBL Gene Tree for PIK3C2G (if available)
    TreeFam Gene Tree for PIK3C2G (if available) 

    Paralogs
    for PIK3C2G gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PIK3C2G gene
    PIK3CD2  PIK3C2B2  PIK3CA2  PIK3CG2  PIK3CB2  PIK3C32  PIK3C2A2  
    8 SIMAP similar genes for PIK3C2G using alignment to 5 protein entries:     P3C2G_HUMAN (see all proteins):
    DKFZp686G16234    PIK3CB    PIK3CG    PIK3C2B variant protein    DKFZp779K1237    PIK3C2B
    PIK3C2A    PI4KB

    PIK3C2G for paralogs           About GeneDecksing



    Genomic Variants
    for PIK3C2G gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6608 NCBI SNPs in PIK3C2G are shown (see all 6608)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs38138981,2
    		C--18412483(-) CCACTC/GTAAAG 1 -- us2k10--------
    rs1163762401,2
    		F--18412494(+) GGGGAA/CATAAG 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs38138971,2
    		C,F,A,H--18412607(-) TAAGAT/GTCAAA 1 -- us2k117Minor allele frequency- G:0.48NA NS EA WA CSA 923
    rs38413691,2
    		C--18412683(-) TTTACA/-GTGCA 1 -- us2k11Minor allele frequency- -:0.00CSA 2
    rs725257971,2
    		C--18412683(+) TGCAC-/TCGTAA 1 -- us2k10--------
    rs42379731,2
    		C,F,A,H--18412764(+) AAAAAC/TGGAGT 1 -- us2k111Minor allele frequency- T:0.50NA WA CSA EA 509
    rs42671191,2
    		C,F,A--18412858(+) AGAAGC/TTTAAT 1 -- us2k1 tfbs39Minor allele frequency- T:0.29NA WA EA 500
    rs110439841,2
    		--18412865(+) TAATTG/ATTCTC 1 -- us2k1 tfbs33Minor allele frequency- A:0.28CSA NA EA 241
    rs1506691361,2
    		C--18412912(+) TAAGC-/GTGTACA 1 -- us2k10--------
    rs1466406581,2
    		C--18413097(+) TAAGT-/CCTCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PIK3C2G (18400548 - 18650548 bp, first 250kb of PIK3C2G)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for PIK3C2G
         5 CNVs: 86248 1250 101443 1896 66153
         2 Indels: 24965 33557
    Human Gene Mutation Database (HGMD): PIK3C2G

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    Disorders / Diseases
    for PIK3C2G gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PIK3C2G for disorders           About GeneDecksing

    OMIM gene information: 609001    OMIM disorders: --

    8 diseases for PIK3C2G:    About MalaCards
    kaposi's sarcoma    sarcoma    cholesterol    schizophrenia
    immunodeficiency    prostatitis    neuronitis    alcoholism

    Human Genome Epidemiology (HuGE) Navigator: PIK3C2G (5 documents)

    Export disorders for PIK3C2G gene to outside databases

    Publications
    for PIK3C2G gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PIK3C2G gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with PIK3C2G)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12. (PubMed id 9878262)1, 2, 3, 9 Rozycka M.... Fry M.J. (1998)
    2. Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population. (PubMed id 17991425)1, 2 Daimon M....Kato T. (2008)
    3. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    4. Akt/Nox2/NF-I_B signaling pathway is involved in Tat-i nduced HIV-1 long terminal repeat (LTR) transactivation. (PubMed id 21029719)1 Zhang H.S....Wang Y.O. (2011)
    5. Physiogenomic analysis of statin-treated patients: do main-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1 RuaA+o G....Wu A.H. (2010)
    6. Erythropoietin plus insulin-like growth factor-I prote cts against neuronal damage in a murine model of human immunodeficiency virus-as sociated neurocognitive disorders. (PubMed id 20818790)1 Kang Y.J....Lipton S.A. (2010)
    7. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PubMed id 18996102)1 RuaA+o G....Hanks S. (2009)
    8. Human immunodeficiency virus type 1 Tat accelerates K aposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transf ormed fibroblasts in vitro as well as in nude and immunocompetent mice. (PubMed id 20019835)1 Chen X....Lu C. (2009)
    9. HIV Nef enhances Tat-mediated viral transcription through a hnRNP-K-nucleated signaling complex. (PubMed id 18854243)1 Wolf D....Baur A.S. (2008)
    10. Signaling mechanism of HIV-1 gp120 and virion-induced IL-1beta release in primary human macrophages. (PubMed id 18453587)1 Cheung R....Collman R.G. (2008)

    External Searches for PIK3C2G gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    Genome Databases showing PIK3C2G gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5288 HGNC: 8973 AceView: PIK3C2G Ensembl:ENSG00000139144 euGenes: HUgn5288
    ECgene: PIK3C2G Kegg: 5288 H-InvDB: PIK3C2G

    Other Databases showing PIK3C2G gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PIK3C2G gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PIK3C2G Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PIK3C2G Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PIK3C2G gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PIK3C2G gene:
    Search GeneIP for patents involving PIK3C2G

    GeneCards and IP:
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