Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PIK3C2G Gene

protein-coding   GIFtS: 62
GCID: GC12P018414

Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit...

(Previous names: phosphoinositide-3-kinase, class 2, gamma polypeptide)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2
Gamma1 2
     Phosphatidylinositol 3-Kinase C2 Domain-Containing Gamma2
Phosphoinositide-3-Kinase, Class 2, Gamma Polypeptide1 2     Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit
Gamma2
Phosphoinositide 3-Kinase-C2-Gamma2 3     Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing Gamma
Polypeptide2
PtdIns-3-Kinase C2 Subunit Gamma2 3     Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing Subunit
Gamma2
PI3K-C2-gamma2 3     PTDINS-3-Kinase C2 Gamma2
EC 2.7.1.1543 8     EC 2.7.18
PI3K-C2GAMMA2     

External Ids:    HGNC: 89731   Entrez Gene: 52882   Ensembl: ENSG000001391447   OMIM: 6090015   UniProtKB: O757473   

Export aliases for PIK3C2G gene to outside databases

Previous GC identifers: GC12P018154 GC12P018559 GC12P018314 GC12P018305


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PIK3C2G Gene:
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in
signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and
intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal
C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding
motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions.
The biological function of this gene has not yet been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for PIK3C2G Gene: 
PIK3C2G (phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma) is a protein-coding gene. Diseases associated with PIK3C2G include kaposi's sarcoma, and sarcoma, and among its related super-pathways are PI Metabolism and Phosphatidylinositol signaling system. GO annotations related to this gene include 1-phosphatidylinositol-4-phosphate 3-kinase activity and phosphatidylinositol binding. An important paralog of this gene is PIK3C2B.

UniProtKB/Swiss-Prot: P3C2G_HUMAN, O75747
Function: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate
(PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity)

summary for PIK3C2G Gene:
PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the
3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of
cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell
migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric
consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and
delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst
p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have
recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes
(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI
3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to
play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3C2G Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PIK3C2G gene promoter:
         C/EBPbeta   Nkx5-1   NF-AT   AREB6   NF-AT4   POU2F1   NF-AT2   POU2F1a   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIK3C2G promoter sequence
   Search SABiosciences Chromatin IP Primers for PIK3C2G

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIK3C2G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p12

PIK3C2G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIK3C2G gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P018414:  view genomic region     (about GC identifiers)

Start:
18,400,548 bp from pter      End:
18,801,352 bp from pter
Size:
400,805 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: P3C2G_HUMAN, O75747 (See protein sequence)
Recommended Name: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma  
Size: 1445 amino acids; 165715 Da
Subcellular location: Membrane; Peripheral membrane protein (By similarity)
Sequence caution: Sequence=CAA03853.1; Type=Erroneous termination; Positions=1446; Note=Translated as stop;
1 PDB 3D structure from and Proteopedia for PIK3C2G:
2WWE (3D)    
Secondary accessions: A1L3U0

Explore the universe of human proteins at neXtProt for PIK3C2G: NX_O75747

Explore proteomics data for PIK3C2G at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75747

  • 4 DME Specific Peptides for PIK3C2G (O75747)
     KRDRAPF  DLRQDML  DRHNDNIM  CDRHNDNIML 

    PIK3C2G Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PIK3C2G Protein Expression
    REFSEQ proteins: NP_004561.3  
    ENSEMBL proteins: 
     ENSP00000443850   ENSP00000441618   ENSP00000266497   ENSP00000404845   ENSP00000445381  
    Reactome Protein details: O75747
    Human Recombinant Protein Products for PIK3C2G: 
    EMD Millipore Purified and/or Recombinant PIK3C2G Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PIK3C2G
    GenScript Custom Purified and Recombinant Proteins Services for PIK3C2G
    Novus Biologicals PIK3C2G Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IBA--
    GO:0005942phosphatidylinositol 3-kinase complex IBA--

    PIK3C2G for ontologies           About GeneDecksing



    PIK3C2G Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PIK3C2G
    GenScript Custom Superior Antibodies Services for PIK3C2G
    Novus Biologicals PIK3C2G Antibodies
    Abcam antibodies for PIK3C2G
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for PIK3C2G
    Search LSBio for Antibodies for PIK3C2G 

    Assay Products for PIK3C2G: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PIK3C2G
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PIK3C2G
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 
    Phosphatidylinositol-4-phosphate 3-kinase family

    5/11 InterPro protein domains (see all 11):
     IPR001263 PInositide-3_kin_accessory_dom
     IPR002420 PI3K_C2_dom
     IPR001683 Phox
     IPR011009 Kinase-like_dom
     IPR000403 PI3/4_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry O75747

    ProtoNet protein and cluster: O75747

    4 Blocks protein domains:
    IPB000008 C2 domain
    IPB000341 Phosphoinositide 3-kinase
    IPB000403 Phosphatidylinositol 3- and 4-kinase
    IPB001683 Phox-like


    UniProtKB/Swiss-Prot: P3C2G_HUMAN, O75747
    Similarity: Belongs to the PI3/PI4-kinase family
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 C2 PI3K-type domain
    Similarity: Contains 1 PI3K-RBD domain
    Similarity: Contains 1 PI3K/PI4K domain
    Similarity: Contains 1 PIK helical domain
    Similarity: Contains 1 PX (phox homology) domain


    PIK3C2G for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P3C2G_HUMAN, O75747
    Function: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate
    (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity)
    Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol
    3,4-bisphosphate

         Genatlas biochemistry entry for PIK3C2G:
    phosphatidylinositol 3-kinase class 2,gamma polypeptide,expressed in normal breast,liver,prostate and other
    tissues

         Enzyme Numbers (IUBMB): EC 2.7.1.1541 2 EC 2.7.12

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
    GO:00163031-phosphatidylinositol-3-kinase activity NAS9878262
         
    PIK3C2G for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PIK3C2G:
     Decreased CYP1A1 activity afte  Decreased focal adhesion (FA)   Decreased influenza A/WSN/33 r  Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PIK3C2G 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PIK3C2G

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PIK3C2G 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PIK3C2G 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIK3C2G
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate PIK3C2G:
    hsa-miR-569 hsa-miR-183* hsa-miR-1244 hsa-miR-29a* hsa-miR-548u
    SwitchGear 3'UTR luciferase reporter plasmidPIK3C2G 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PIK3C2G
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIK3C2G

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PIK3C2G
    Sirion Biotech Customized adenovirus for overexpression of PIK3C2G

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PIK3C2G (see all 6)
    OriGene ORF clones in mouse, rat for PIK3C2G
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PIK3C2G (NM_004570)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIK3C2G
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3C2G
    Sirion Biotech Customized lentivirus for stable overexpression of PIK3C2G 
                         Customized lentivirus expression plasmids for stable overexpression of PIK3C2G 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PIK3C2G
    Search LifeMap BioReagents cell lines for PIK3C2G
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3C2G


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PIK3C2G About   (see all 15)                                                                                              See pathways by source

    SuperPathContained pathways About
    1PI Metabolism
    PI Metabolism0.66
    3-phosphoinositide biosynthesis0.48
    Synthesis of PIPs at the plasma membrane0.66
    2Inositol phosphate metabolism
    Inositol phosphate metabolism0.61
    superpathway of inositol phosphate compounds0.60
    Phosphatidylinositol signaling system0.61
    3Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    4Apoptosis Pathway
    Apoptosis Pathway0.45
    Akt Pathway0.39
    NF-kappaB Pathway0.45
    5mTOR Pathway
    mTOR Pathway0.38
    Insulin Pathway0.32
    TGF-beta Pathway0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PIK3C2G
        Molecular Mechanisms of Cancer
    ICos-ICosL Pathway in T-Helper Cell
    PI3K Signaling in B-Lymphocyte
    CD28 Signaling in T-Helper Cell

    5/9 Tocris Bioscience Pathways for PIK3C2G (see all 9)
        Akt Pathway
    Insulin Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    Toll-like Receptor Pathway

    5 BioSystems Pathways for PIK3C2G
        Insulin Signaling
    Signaling Pathways in Glioblastoma
    Regulation of Actin Cytoskeleton
    3-phosphoinositide biosynthesis
    superpathway of inositol phosphate compounds

    5/6        Reactome Pathways for PIK3C2G (see all 6)
        Metabolism
    Synthesis of PIPs at the plasma membrane
    Phospholipid metabolism
    Metabolism of lipids and lipoproteins
    PI Metabolism


    3         Kegg Pathways  (Kegg details for PIK3C2G):
        Inositol phosphate metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system


    PIK3C2G for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIK3C2G

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/30 Interacting proteins for PIK3C2G (ENSP000004048454) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PI4K2AENSP000003596654STRING: ENSP00000359665
    PI4K2BENSP000002648644STRING: ENSP00000264864
    PI4KAENSP000002558824STRING: ENSP00000255882
    PI4KBENSP000002716574STRING: ENSP00000271657
    PIP5K1BENSP000002653824STRING: ENSP00000265382
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0006935chemotaxis IEA--
    GO:0007154cell communication ----
    GO:0008150biological_process ND--

    PIK3C2G for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for PIK3C2G:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PIK3C2G available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CZC 24832Selective inhibitor of PI 3-Kinase gamma[1159824-67-5]
    QuercetinNon-selective PI 3-kinase inhibitor[117-39-5]
    PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK [371935-74-9]
    AS 605240Potent and selective PI 3-kinase gamma (PI3Kgamma) inhibitor[648450-29-7]
    740 Y-PCell-permeable PI 3-kinase activator[1236188-16-1]

    2 HMDB Compounds for PIK3C2G    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about PIK3C2G / P3C2G

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PIK3C2G gene: 
    NM_004570.4  

    Unigene Cluster for PIK3C2G:

    Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
    Hs.22500  [show with all ESTs]
    Unigene Representative Sequence: AJ000008
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000535651 ENST00000546003 ENST00000266497 ENST00000536967 ENST00000538458
    ENST00000433979(uc001rdt.3 uc010sia.2 uc010sib.2 uc010sic.2)
    ENST00000538779
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIK3C2G
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate PIK3C2G:
    hsa-miR-569 hsa-miR-183* hsa-miR-1244 hsa-miR-29a* hsa-miR-548u
    SwitchGear 3'UTR luciferase reporter plasmidPIK3C2G 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PIK3C2G
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIK3C2G
    Clone
    Products:
         
    OriGene clones in human, mouse for PIK3C2G (see all 6)
    OriGene ORF clones in mouse, rat for PIK3C2G
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PIK3C2G (NM_004570)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIK3C2G
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3C2G
    Sirion Biotech Customized lentivirus for stable overexpression of PIK3C2G 
                         Customized lentivirus expression plasmids for stable overexpression of PIK3C2G 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PIK3C2G
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PIK3C2G
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIK3C2G
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIK3C2G

    Additional mRNA sequence: 

    AJ000008.1 BC130277.1 BC144133.1 BC144134.1 

    2 DOTS entries:

    DT.442133  DT.102824490 

    24/33 AceView cDNA sequences (see all 33):

    R43405 AL699201 AA906464 BX092808 NM_004570 BG207636 AA724283 AI478164 
    AI024088 BG187979 CD618956 AI796188 BU687433 AA970382 AI005414 AJ000008 
    CD618954 BG186950 AI373752 AI808155 AA970381 CD618959 R22699 AW195485 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PIK3C2G expression in normal human tissues (normalized intensities)      PIK3C2G embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PIK3C2G Expression
    About this image


    PIK3C2G expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Hair
             hair follicle bulge   
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Granulosa Cells Primary Follicle
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             hair follicle bulge   
     
     Pancreas (Endocrine System)
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...
     
     Endothelium (Cardiovascular System)
             blood vessel   

    See PIK3C2G Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PIK3C2G

    SOURCE GeneReport for Unigene cluster: Hs.22500

    UniProtKB/Swiss-Prot: P3C2G_HUMAN, O75747
    Tissue specificity: Highly expressed in liver, prostate and testis. Lower levels in small intestine, kidney and
    pancreas

        SABiosciences Custom PCR Arrays for PIK3C2G
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PIK3C2G
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PIK3C2G
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIK3C2G
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIK3C2G
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3C2G

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PIK3C2G gene from 5/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pik3c2g1 , 5 phosphatidylinositol 3-kinase, C2 domain containing, more1, 5 79.88(n)1
    73.29(a)1
      6 (69.70 cM)5
    187051  NM_207683.21  NP_997566.11 
     1396140725 
    chicken
    (Gallus gallus)
    Aves PIK3C2G1 phosphoinositide-3-kinase, class 2, gamma polypeptide 66.62(n)
    58.25(a)
      418181  XM_416412.3  XP_416412.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pi3K68D6
    Phosphotidylinositol 3 kinase 68D
    20(a)
    1 → many
    3L(11767750-11783113)
    worm
    (Caenorhabditis elegans)
    Secernentea age-16
    piki-16
    Protein PIKI-1
    20(a)
    20(a)
    possible ortholog
    many → 1
    II(11519499-11527062)
    X(15234832-15246365)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS346
    Phosphatidylinositol 3-kinase responsible for the ...
    19(a)
    1 → many
    XII(617533-620160)


    ENSEMBL Gene Tree for PIK3C2G (if available)
    TreeFam Gene Tree for PIK3C2G (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PIK3C2G gene
    PIK3C2B2  PIK3CD2  PIK3CA2  PIK3CG2  PIK3C32  PIK3CB2  PIK3C2A2  
    9 SIMAP similar genes for PIK3C2G using alignment to 5 protein entries:     P3C2G_HUMAN (see all proteins):
    DKFZp686G16234    PIK3CB    PIK3CG    PIK3C3    PIK3C2B variant protein    DKFZp779K1237
    PIK3C2B    PIK3C2A    PI4KB

    PIK3C2G for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7688 SNPs in PIK3C2G are shown (see all 7688)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38138981,2
    C--18412483(-) CCACTC/GTAAAG 1 -- us2k10--------
    rs1163762401,2
    F--18412494(+) GGGGAA/CATAAG 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs38138971,2
    C,F,A,H--18412607(-) TAAGAT/GTCAAA 1 -- us2k117Minor allele frequency- G:0.48NA NS EA WA CSA 923
    rs38413691,2
    C--18412683(-) TTTACA/-GTGCA 1 -- us2k11Minor allele frequency- -:0.00CSA 2
    rs725257971,2
    C--18412683(+) TGCAC-/TCGTAA 1 -- us2k10--------
    rs668471471,2
    C--18412684(+) GCACG-/TTAAAC 1 -- us2k10--------
    rs42379731,2
    C,F,A,H--18412764(+) AAAAAC/TGGAGT 1 -- us2k111Minor allele frequency- T:0.50NA WA CSA EA 509
    rs42671191,2
    C,F,A--18412858(+) AGAAGC/TTTAAT 1 -- us2k1 tfbs39Minor allele frequency- T:0.29NA WA EA 500
    rs110439841,2
    C--18412865(+) TAATTG/ATTCTC 1 -- us2k1 tfbs33Minor allele frequency- A:0.28CSA NA EA 241
    rs1506691361,2
    C--18412912(+) TAAGC-/GTGTACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PIK3C2G (18400548 - 18650548 bp, first 250kb of PIK3C2G)

    Structural Variations
         Database of Genomic Variants (DGV) 10/25 variations for PIK3C2G (see all 25):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745610CNV Deletion23290073
    esv2745612CNV Deletion23290073
    esv2674487CNV Deletion23128226
    esv2672387CNV Deletion23128226
    esv2745611CNV Deletion23290073
    esv2650294CNV Deletion19546169
    esv1542857CNV Deletion17803354
    esv267505CNV Insertion20981092
    esv268773CNV Insertion20981092
    esv1370525CNV Insertion17803354


    Human Gene Mutation Database (HGMD): PIK3C2G
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PIK3C2G
    DNA2.0 Custom Variant and Variant Library Synthesis for PIK3C2G

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609001    OMIM disorders: --

    9 diseases for PIK3C2G:    About MalaCards
    kaposi's sarcoma    sarcoma    glioblastoma    alcoholism
    schizophrenia    prostate cancer    endotheliitis    prostatitis
    neuronitis


    PIK3C2G for disorders           About GeneDecksing

    Genetic Association Database (GAD): PIK3C2G
    Human Genome Epidemiology (HuGE) Navigator: PIK3C2G (5 documents)

    Export disorders for PIK3C2G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PIK3C2G gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with PIK3C2G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12. (PubMed id 9878262)1, 2, 3, 9 Rozycka M.... Fry M.J. (1998)
    2. Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population. (PubMed id 17991425)1, 2, 4 Daimon M....Kato T. (2008)
    3. Physiogenomic analysis of statin-treated patients: do main-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (2010)
    4. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PubMed id 18996102)1, 4 RuaA+o G....Hanks S. (2009)
    5. An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia. (PubMed id 17893707)1, 4 Jungerius B.J....Sinke R.J. (2007)
    6. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    7. Akt/Nox2/NF-I_B signaling pathway is involved in Tat-i nduced HIV-1 long terminal repeat (LTR) transactivation. (PubMed id 21029719)1 Zhang H.S....Wang Y.O. (2011)
    8. Erythropoietin plus insulin-like growth factor-I prote cts against neuronal damage in a murine model of human immunodeficiency virus-as sociated neurocognitive disorders. (PubMed id 20818790)1 Kang Y.J....Lipton S.A. (2010)
    9. Human immunodeficiency virus type 1 Tat accelerates K aposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transf ormed fibroblasts in vitro as well as in nude and immunocompetent mice. (PubMed id 20019835)1 Chen X....Lu C. (2009)
    10. HIV Nef enhances Tat-mediated viral transcription through a hnRNP-K-nucleated signaling complex. (PubMed id 18854243)1 Wolf D....Baur A.S. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5288 HGNC: 8973 AceView: PIK3C2G Ensembl:ENSG00000139144 euGenes: HUgn5288
    ECgene: PIK3C2G Kegg: 5288 H-InvDB: PIK3C2G

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PIK3C2G Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PIK3C2G Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PIK3C2G gene:
    Search GeneIP for patents involving PIK3C2G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore small molecules (inhibitor) for PIK3C2G
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Purified and/or Recombinant PIK3C2G Protein
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PIK3C2G  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PIK3C2G  
     OriGene qSTAR qPCR primer pairs in human, mouse for PIK3C2G   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PIK3C2G   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PIK3C2G   OriGene Custom Protein Services for PIK3C2G  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PIK3C2G
     QIAGEN SeqTarget long-range PCR primers for resequencing PIK3C2G
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIK3C2G
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIK3C2G
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIK3C2G
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIK3C2G
     GenScript Custom Purified and Recombinant Proteins Services for PIK3C2G GenScript cDNA clones with any tag delivered in your preferred vector for PIK3C2G
     GenScript Custom Assay Services for PIK3C2G GenScript Custom Superior Antibodies Services for PIK3C2G
     GenScript Custom overexpressing Cell Line Services for PIK3C2G CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PIK3C2G promoter
     Search Chromatin IP Primers for PIK3C2G
     RT2 qPCR Primer Assay in human, mouse, rat PIK3C2G
     GNC Network for PIK3C2G
     SABiosciences PCR Arrays including human, mouse, rat PIK3C2G
     Tocris compounds for PIK3C2G
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PIK3C2G antibodies
     PIK3C2G proteins
     Antibodies for PIK3C2G
     See all of Abcam's Antibodies, Kits and Proteins for PIK3C2G
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for PIK3C2G
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3C2G
     SwitchGear 3'UTR luciferase reporter plasmids for PIK3C2G
     SwitchGear Promoter luciferase reporter plasmids for PIK3C2G
     ThermoFisher Antibodies for PIK3C2G
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3C2G
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PIK3C2G
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PIK3C2G
    Customized:
     lentivirus for stable overexpression of PIK3C2G
     lentivirus expression plasmids for stable overexpression of PIK3C2G
     adenovirus for overexpression of PIK3C2G
     Search LSBio for Antibodies for PIK3C2G
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PIK3C2G gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4