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Aliases for PIK3C2B Gene

Aliases for PIK3C2B Gene

  • Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 Beta 2 3
  • Phosphoinositide-3-Kinase, Class 2, Beta Polypeptide 2 3
  • Phosphoinositide 3-Kinase-C2-Beta 3 4
  • PtdIns-3-Kinase C2 Subunit Beta 3 4
  • PI3K-C2-Beta 3 4
  • EC 2.7.1.154 4 63
  • C2-PI3K 3 4
  • Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit Beta 3
  • Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing Subunit Beta 3
  • Phosphatidylinositol 3-Kinase C2 Domain-Containing Beta Polypeptide 3
  • PTDINS-3-Kinase C2 Beta 3
  • PI3K-C2beta 3
  • EC 2.7.1 63

External Ids for PIK3C2B Gene

Summaries for PIK3C2B Gene

Entrez Gene Summary for PIK3C2B Gene

  • The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]

GeneCards Summary for PIK3C2B Gene

PIK3C2B (Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 Beta) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and VEGF Signaling Pathway. GO annotations related to this gene include phosphatidylinositol binding and 1-phosphatidylinositol-4-phosphate 3-kinase activity. An important paralog of this gene is PIK3CB.

UniProtKB/Swiss-Prot for PIK3C2B Gene

  • Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.

Tocris Summary for PIK3C2B Gene

  • PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the 3OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes (C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI 3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3C2B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIK3C2B Gene

Genomics for PIK3C2B Gene

Genomic Location for PIK3C2B Gene

Start:
204,422,628 bp from pter
End:
204,494,815 bp from pter
Size:
72,188 bases
Orientation:
Minus strand

Genomic View for PIK3C2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIK3C2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIK3C2B Gene

Regulatory Elements for PIK3C2B Gene

Proteins for PIK3C2B Gene

  • Protein details for PIK3C2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00750-P3C2B_HUMAN
    Recommended name:
    Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
    Protein Accession:
    O00750
    Secondary Accessions:
    • O95666
    • Q5SW99

    Protein attributes for PIK3C2B Gene

    Size:
    1634 amino acids
    Molecular mass:
    184768 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Part of a complex with ERBB2 and EGFR. Part of a complex with phosphorylated EGFR and GRB2. Interacts with phosphorylated EGFR and PDGFR, maybe indirectly. Interacts with GRB2 and SHC1.
    SequenceCaution:
    • Sequence=CAA74194.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PIK3C2B Gene

Proteomics data for PIK3C2B Gene at MOPED

Post-translational modifications for PIK3C2B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys12, Lys22, Lys70, Lys201, Lys241, Lys267, Lys752, Lys1027, Lys1047, and Lys1152

Other Protein References for PIK3C2B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PIK3C2B Gene

Graphical View of Domain Structure for InterPro Entry

O00750

UniProtKB/Swiss-Prot:

P3C2B_HUMAN
Domain:
  • Contains 1 C2 domain.:
    • O00750
  • Contains 1 C2 PI3K-type domain.:
    • O00750
  • Contains 1 PI3K-RBD domain.:
    • O00750
  • Contains 1 PI3K/PI4K domain.:
    • O00750
  • Contains 1 PIK helical domain.:
    • O00750
  • Contains 1 PX (phox homology) domain.:
    • O00750
Family:
  • Belongs to the PI3/PI4-kinase family.:
    • O00750
genes like me logo Genes that share domains with PIK3C2B: view

Function for PIK3C2B Gene

Molecular function for PIK3C2B Gene

GENATLAS Biochemistry: phosphatidylinositol 3-kinase,class 2,widely expressed
UniProtKB/Swiss-Prot CatalyticActivity: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by GRB2.
UniProtKB/Swiss-Prot Function: Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.

Enzyme Numbers (IUBMB) for PIK3C2B Gene

Gene Ontology (GO) - Molecular Function for PIK3C2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001727 lipid kinase activity IEA --
GO:0005488 binding --
GO:0005515 protein binding IPI 10805725
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity --
genes like me logo Genes that share ontologies with PIK3C2B: view
genes like me logo Genes that share phenotypes with PIK3C2B: view

Animal Models for PIK3C2B Gene

MGI Knock Outs for PIK3C2B:

miRNA for PIK3C2B Gene

miRTarBase miRNAs that target PIK3C2B

No data available for Transcription Factor Targeting and HOMER Transcription for PIK3C2B Gene

Localization for PIK3C2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIK3C2B Gene

Microsome. Cell membrane. Cytoplasm, cytosol. Nucleus. Endoplasmic reticulum. Note=Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIK3C2B Gene COMPARTMENTS Subcellular localization image for PIK3C2B gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
nucleus 5
plasma membrane 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PIK3C2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0005942 phosphatidylinositol 3-kinase complex IBA --
genes like me logo Genes that share ontologies with PIK3C2B: view

Pathways for PIK3C2B Gene

genes like me logo Genes that share pathways with PIK3C2B: view

Gene Ontology (GO) - Biological Process for PIK3C2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0008150 biological_process ND --
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IBA --
GO:0043491 protein kinase B signaling IEA --
genes like me logo Genes that share ontologies with PIK3C2B: view

Compounds for PIK3C2B Gene

(5) Tocris Compounds for PIK3C2B Gene

Compound Action Cas Number
740 Y-P Cell-permeable PI 3-kinase activator [1236188-16-1]
AS 605240 Potent and selective PI 3-kinase gamma (PI3Kgamma) inhibitor [648450-29-7]
CZC 24832 Selective inhibitor of PI 3-Kinase gamma [1159824-67-5]
PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK [371935-74-9]
Quercetin Non-selective PI 3-kinase inhibitor [117-39-5]

(5) HMDB Compounds for PIK3C2B Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2
Magnesium
  • Magnesium
7439-95-4
Manganese
  • manganese
7439-96-5

(3) Novoseek inferred chemical compound relationships for PIK3C2B Gene

Compound -log(P) Hits PubMed IDs
phosphoinositide 68.3 4
phosphotyrosine 55.4 1
lipid 24.3 2
genes like me logo Genes that share compounds with PIK3C2B: view

Transcripts for PIK3C2B Gene

Unigene Clusters for PIK3C2B Gene

Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIK3C2B Gene

No ASD Table

Relevant External Links for PIK3C2B Gene

GeneLoc Exon Structure for
PIK3C2B
ECgene alternative splicing isoforms for
PIK3C2B

Expression for PIK3C2B Gene

mRNA expression in normal human tissues for PIK3C2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIK3C2B Gene

SOURCE GeneReport for Unigene cluster for PIK3C2B Gene Hs.497487

mRNA Expression by UniProt/SwissProt for PIK3C2B Gene

O00750-P3C2B_HUMAN
Tissue specificity: Expressed in columnar and transitional epithelia, mononuclear cells, and ganglion cells (at protein level). Widely expressed, with highest levels in thymus and placenta and lowest in peripheral blood, skeletal muscle and kidney.
genes like me logo Genes that share expressions with PIK3C2B: view

No data available for mRNA differential expression in normal tissues for PIK3C2B Gene

Orthologs for PIK3C2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIK3C2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIK3C2B 35
  • 98.35 (n)
  • 97.98 (a)
PIK3C2B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PIK3C2B 35
  • 90.43 (n)
  • 93.69 (a)
PIK3C2B 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIK3C2B 35
  • 91.15 (n)
  • 94.43 (a)
PIK3C2B 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pik3c2b 35
  • 88.83 (n)
  • 93.75 (a)
Pik3c2b 16
Pik3c2b 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIK3C2B 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIK3C2B 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pik3c2b 35
  • 88.44 (n)
  • 93.4 (a)
chicken
(Gallus gallus)
Aves PIK3C2B 35
  • 79.01 (n)
  • 83.46 (a)
PIK3C2B 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIK3C2B 36
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pik3c2b 35
  • 65.98 (n)
  • 65.83 (a)
pik3c2b 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pi3K68D 36
  • 30 (a)
OneToMany
Pi3K68D 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea piki-1 36
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS34 36
  • 21 (a)
OneToMany
Species with no ortholog for PIK3C2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PIK3C2B Gene

ENSEMBL:
Gene Tree for PIK3C2B (if available)
TreeFam:
Gene Tree for PIK3C2B (if available)

Paralogs for PIK3C2B Gene

Paralogs for PIK3C2B Gene

genes like me logo Genes that share paralogs with PIK3C2B: view

Variants for PIK3C2B Gene

Sequence variations from dbSNP and Humsavar for PIK3C2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs471542 -- 204,489,713(+) TTTCA(A/G)AAAAT intron-variant
rs548419 -- 204,496,340(+) TTTTG(A/G/T)ATTTT upstream-variant-2KB
rs548423 -- 204,496,340(+) ttggg(A/T)tttta upstream-variant-2KB
rs556284 -- 204,496,383(-) tcgag(A/C)ccatc upstream-variant-2KB
rs938125 -- 204,481,354(-) GGAGG(C/T)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIK3C2B Gene

Variant ID Type Subtype PubMed ID
nsv516276 CNV Loss 19592680
esv2721851 CNV Deletion 23290073
esv1350665 CNV Deletion 17803354
esv2721862 CNV Deletion 23290073
esv2721873 CNV Deletion 23290073
esv2721884 CNV Deletion 23290073
esv2721895 CNV Deletion 23290073

Relevant External Links for PIK3C2B Gene

HapMap Linkage Disequilibrium report
PIK3C2B
Human Gene Mutation Database (HGMD)
PIK3C2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIK3C2B Gene

Disorders for PIK3C2B Gene

Relevant External Links for PIK3C2B

Genetic Association Database (GAD)
PIK3C2B
Human Genome Epidemiology (HuGE) Navigator
PIK3C2B
genes like me logo Genes that share disorders with PIK3C2B: view

No data available for UniProtKB/Swiss-Prot for PIK3C2B Gene

Publications for PIK3C2B Gene

  1. Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. (PMID: 10805725) Arcaro A. … Domin J. (Mol. Cell. Biol. 2000) 3 4 23
  2. Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2. (PMID: 11533253) Wheeler M. … Domin J. (Mol. Cell. Biol. 2001) 3 4 23
  3. Identification and cDNA cloning of a novel mammalian C2 domain- containing phosphoinositide 3-kinase, HsC2-PI3K. (PMID: 9144573) Brown R.A. … Fry M.J. (Biochem. Biophys. Res. Commun. 1997) 2 3 4
  4. Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity. (PMID: 9830063) Arcaro A. … Waterfield M.D. (J. Biol. Chem. 1998) 2 3 4
  5. Topographical expression of class IA and class II phosphoinositide 3- kinase enzymes in normal human tissues is consistent with a role in differentiation. (PMID: 14563213) El Sheikh S.S. … Lalani E.-N. (BMC Clin. Pathol. 2003) 3 4

Products for PIK3C2B Gene

Sources for PIK3C2B Gene

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