PIK3C2B Gene
protein-coding GIFtS: 65
GCID: GC01M204391
|
|
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit...(Previous names: phosphoinositide-3-kinase, class 2, beta polypeptide )
| |
Aliases
for PIK3C2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 Beta1 2 | | EC 2.7.1.1543 8 | | C2-PI3K1 2 3 | | Phosphatidylinositol 3-Kinase C2 Domain-Containing Beta Polypeptide2 | | PI3K-C2beta1 2 | | Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit Beta2 | | Phosphoinositide-3-Kinase, Class 2, Beta Polypeptide1 2 | | Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing Subunit Beta2 | | Phosphoinositide 3-Kinase-C2-Beta2 3 | | PTDINS-3-Kinase C2 Beta2 | | PtdIns-3-Kinase C2 Subunit Beta2 3 | | EC 2.7.18 | | PI3K-C2-Beta1 | | |
Export aliases for PIK3C2B gene to outside databasesPrevious GC identifers: GC01M202118 GC01M199852 GC01M200752 GC01M201569 GC01M201123 GC01M202658 GC01M202538 GC01M175556 |
Summaries
for PIK3C2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PIK3C2B:
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles insignaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, andintracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs thatmediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinaseactivity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of thisprotein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in acalcium-independent manner. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: P3C2B_HUMAN, O00750Function: Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May beinvolved in EGF and PDGF signaling cascades
 summary
for PIK3C2B: PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the
3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of
cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell
migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric
consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and
delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst
p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have
recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes
(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI
3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to
play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.
Gene Wiki entry for PIK3C2B
|
Genomic Views
for PIK3C2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PIK3C2B gene promoter:
Elk-1 NF-AT PPAR-alpha MEF-2A NF-AT4 NF-AT2 NF-AT3 aMEF-2 Pax-4a NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PIK3C2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIK3C2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q32 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32PIK3C2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M204391: view genomic region
(about GC identifiers)
Start:
|
204,391,756 bp from pter |
End:
|
204,463,852 bp from pter |
Size:
|
72,097 bases |
Orientation:
|
minus strand |
|
Proteins
for PIK3C2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: P3C2B_HUMAN, O00750 (See
protein sequence)Recommended Name: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta Size: 1634 amino acids; 184768 Da
Cofactor: Calcium, magnesium, or manganese
Subunit: Part of a complex with ERBB2 and EGFR. Part of a complex with phosphorylated EGFR and GRB2. Interacts withphosphorylated EGFR and PDGFR, maybe indirectly. Interacts with GRB2 and SHC1
Subcellular location: Microsome. Cell membrane. Cytoplasm, cytosol. Nucleus. Endoplasmic reticulum. Note=Found mostlyin the microsome, but also in the plasma membrane and cytosol. Nuclear in testis
Caution: It is uncertain whether Met-1 or Met-26 is the initiator
Sequence caution: Sequence=CAA74194.1; Type=Erroneous initiation;
Secondary accessions: O95666 Q5SW99Explore the universe of human proteins at neXtProt for PIK3C2B: NX_O00750
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00750
4/11 DME Specific Peptides for PIK3C2B (O00750) (see all 11)
PIK3C2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002637.3
ENSEMBL proteins: ENSP00000356155 ENSP00000356152 ENSP00000401795 ENSP00000409554 ENSP00000400561 Reactome Protein details: O00750
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
PIK3C2B for ontologies About GeneDecksing
PIK3C2B Antibody Products:
Assay Products for PIK3C2B: |
Protein
Domains /
Families
for PIK3C2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PIK3C2B for domains About GeneDecksing
5/12 InterPro domains/families (see all 12):Graphical View of Domain Structure for InterPro Entry O00750ProtoNet protein and cluster: O00750 4 Blocks protein families: IPB000008 C2 domain IPB000341 Phosphoinositide 3-kinase IPB000403 Phosphatidylinositol 3- and 4-kinase IPB001683 Phox-like
UniProtKB/Swiss-Prot: P3C2B_HUMAN, O00750Similarity: Belongs to the PI3/PI4-kinase familySimilarity: Contains 1 C2 domainSimilarity: Contains 1 C2 PI3K-type domainSimilarity: Contains 1 PI3K-RBD domainSimilarity: Contains 1 PI3K/PI4K domainSimilarity: Contains 1 PIK helical domainSimilarity: Contains 1 PX (phox homology) domain |
Function
for PIK3C2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: P3C2B_HUMAN, O00750Function: Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May beinvolved in EGF and PDGF signaling cascadesCatalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol3,4-bisphosphateEnzyme regulation: Activated by GRB2 Genatlas biochemistry entry for PIK3C2B:phosphatidylinositol 3-kinase,class 2,widely expressed
Enzyme Numbers (IUBMB): EC 2.7.1.1541 2 EC 2.7.12
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3C2B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3C2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for PIK3C2B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3C2B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3C2B |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
PIK3C2B for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for PIK3C2B:
Animal Models:
Mouse knock-out Pik3c2btm1.1Pkha for PIK3C2B
2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Pik3c2b):
PIK3C2B for phenotypes About GeneDecksing
|
Pathways & Interactions
for PIK3C2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mTOR Pathway | | | 2 | PI Metabolism | | | 3 | Metabolism | | | 4 | Apoptosis Pathway | | | 5 | Inositol phosphate metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  R&D Systems Pathway for PIK3C2B
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PIK3C2B
5/9 Tocris Bioscience Pathways for PIK3C2B (see all 9)
5/7  BioSystems Pathways for PIK3C2B (see all 7)
5 
Reactome Pathways for PIK3C2B
3  PharmGKB Pathways for PIK3C2B
3 
Kegg Pathways (Kegg details for PIK3C2B):
PIK3C2B for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIK3C2B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/53 Interacting proteins for PIK3C2B (O007501, 2, 3 ENSP000003561554) via UniProtKB, MINT, STRING, and/or I2D (see all 53)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| ERBB2 | P046261, 3, ENSP000002695714 | EBI-641107,EBI-641062 I2D:
score=3 STRING: ENSP00000269571 | | PIK3R1 | P279862, 3, ENSP000002743354 | MINT-8112135 I2D:
score=3 STRING: ENSP00000274335 | | SFN | P319472, 3 | MINT-3975518 I2D:
score=2 | | YWHAZ | P631042, 3 | MINT-3307813 I2D:
score=1 | | GRB2 | P629931, 3, ENSP000003390074 | EBI-641107,EBI-401755 I2D:
score=6 STRING: ENSP00000339007 |
About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006644 | phospholipid metabolic process |
TAS | -- | | GO:0006661 | phosphatidylinositol biosynthetic process |
TAS | -- | | GO:0008150 | biological_process |
ND | -- | | GO:0043491 | protein kinase B signaling cascade |
IEA | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
PIK3C2B for ontologies About GeneDecksing
|
Drugs & Compounds
for PIK3C2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PIK3C2B for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for PIK3C2B |
Compounds for PIK3C2B available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| LY 294002 hydrochloride | Selective PI 3-kinase inhibitor | [154447-36-6] | | Quercetin | Non-selective PI 3-kinase inhibitor | [117-39-5] | | PI 103 hydrochloride | Inhibitor of PI 3-kinase, mTOR and DNA-PK | [371935-74-9] | | Wortmannin | Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 | [19545-26-7] | | PI 828 | PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130) | [942289-87-4] |
5 HMDB Compounds for PIK3C2B About this table
3 Novoseek chemical compound relationships for PIK3C2B gene About this table
Search CenterWatch for drugs/clinical trials and news about PIK3C2B / P3C2B
|
Transcripts
for PIK3C2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PIK3C2B gene: NM_002646.3 Unigene Cluster for PIK3C2B: Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta Hs.497487 [show with all ESTs]Unigene Representative Sequence: Y113128 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367187(uc001haw.3 uc010pqv.2 uc009xbd.1) ENST00000462752
ENST00000479079 ENST00000496872 ENST00000367184 ENST00000415899 ENST00000429009
ENST00000424712(uc001hax.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3C2B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3C2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PIK3C2B (NM_002646) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PIK3C2B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3C2B |
Additional cDNA sequence: AB210006.1 AK123366.1 AK308153.1 BC094741.1 BC132876.1 BC136645.1 BC144342.1 CR749201.1 Y11312.1 Y13892.1 11 DOTS entries: DT.91799809 DT.95361655 DT.314095 DT.101963247 DT.100680061 DT.91746004 DT.95121450 DT.91747213 DT.92072038 DT.91727756 DT.92414676 24/87 AceView cDNA sequences (see all 87): AA923518 CR749201 NM_002646 AI139566 AW262807 AA494135 AW054691 BX280568 AI093064 AA770675 CR608190 AA573474 AA252181 BM678774 AA767504 AI061153 AI669305 BQ223607 AA808032 AW009373 AA242794 AL539599 AW375396 CB960034
GeneLoc Exon Structure
|
Expression
for PIK3C2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PIK3C2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAGTTTAAA
About this image
See PIK3C2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PIK3C2B
SOURCE GeneReport for Unigene cluster: Hs.497487
UniProtKB/Swiss-Prot: P3C2B_HUMAN, O00750Tissue specificity: Expressed in columnar and transitional epithelia, mononuclear cells, and ganglion cells (at proteinlevel). Widely expressed, with highest levels in thymus and placenta and lowest in peripheral blood, skeletal muscleand kidney
SABiosciences Expression via Pathway-Focused PCR Array including PIK3C2B: | Diabetes in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PIK3C2B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PIK3C2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIK3C2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIK3C2B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3C2B |
Orthologs
for PIK3C2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PIK3C2B gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PIK3C2B1 |
phosphoinositide-3-kinase, class 2, beta polypeptide |
78.67(n)
83.15(a) |
|
419822 XM_417956.3 XP_417956.3 |
lizard
(Anolis carolinensis) |
Reptilia |
PIK3C2B6 |
-- |
82(a) |
1 ↔ 1 |
4(117460437-117536579) |
zebrafish
(Danio rerio) |
Actinopterygii |
pik3c2b1 |
phosphoinositide-3-kinase, class 2, beta polypeptide |
65.79(n)
66.2(a) |
|
567938 XM_003199487.1 XP_003199535.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Pi3K68D3 |
phosphorylation phosphatidylinositol
3-kinase |
39(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
piki-16 |
-- |
13(a) |
1 → many |
X(15234763-15246296) |
ENSEMBL Gene Tree for PIK3C2B (if available)
TreeFam Gene Tree for PIK3C2B (if available) |
Paralogs
for PIK3C2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PIK3C2B gene
- PIK3CD2 PIK3CA2 PIK3C2G2 PIK3CG2 PIK3CB2 PIK3C32 PIK3C2A2
13 SIMAP similar genes for PIK3C2B using alignment to 7 protein entries: P3C2B_HUMAN (see all proteins):DKFZp686G16234 PIK3C2B variant protein DOC2A PIK3C2A PIK3CB DKFZp779K1237
PIK3C2G CHR11SYT SYTL2 PIK3CG RIMS1 SYT1
PI4KB
PIK3C2B for paralogs About GeneDecksing
|
Genomic Variants
for PIK3C2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PIK3C2B (204391756 - 204463852 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PIK3C2B
1 CNV: 48234
1 Indel: 24047 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PIK3C2B |
|
Disorders
/ Diseases
for PIK3C2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PIK3C2B for disorders About GeneDecksing
OMIM gene information: 602838
OMIM disorders: --
13  diseases for PIK3C2B: About MalaCardskaposi's sarcoma essential hypertension squamous cell carcinoma gout
sarcoma hypertension prostate cancer cholesterol
prostatitis immunodeficiency carcinoma neuronitis
alcoholism
Human Genome Epidemiology (HuGE) Navigator: PIK3C2B (9 documents)
Export disorders for PIK3C2B gene to outside databases
|
Publications
for PIK3C2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PIK3C2B gene, integrated from 9 sources (see all 72):
(articles sorted by number of sources associating them with PIK3C2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity. (PubMed id 9830063)1, 2, 3 Arcaro A.... Waterfield M.D. (1998)
- Identification and cDNA cloning of a novel mammalian C2 domain- containing phosphoinositide 3-kinase, HsC2-PI3K. (PubMed id 9144573)1, 2, 3 Brown R.A.... Fry M.J. (1997)
- Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2. (PubMed id 11533253)1, 2, 9 Wheeler M. and Domin J. (2001)
- Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. (PubMed id 10805725)1, 2, 9 Arcaro A....Domin J. (2000)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Topographical expression of class IA and class II phosphoinositide 3- kinase enzymes in normal human tissues is consistent with a role in differentiation. (PubMed id 14563213)1, 2 El Sheikh S.S....Lalani E.-N. (2003)
- Epidermal growth factor stimulates translocation of t he class II phosphoinositide 3-kinase PI3K-C2beta to the nucleus. (PubMed id 19496756)1, 9 Banfic H....Domin J. (2009)
- The class II phosphatidylinositol 3 kinase C2beta is required for the activation of the K+ channel KCa3.1 and CD4 T-cells. (PubMed id 19587117)1, 9 Srivastava S....Skolnik E.Y. (2009)
- Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms. (PubMed id 16775008)1, 9 Katso R.M....Arcaro A. (2006)
- The activation of nuclear phosphoinositide 3-kinase C2beta in all-trans-retinoic acid-differentiated HL-60 cells. (PubMed id 12372612)1, 9 Visnjic D....Banfic H. (2002)
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External Searches for PIK3C2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing PIK3C2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing PIK3C2B gene
(According to HUGE)
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Specialized Databases showing PIK3C2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for PIK3C2B gene:
Search GeneIP for patents involving PIK3C2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PIK3C2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for PIK3C2B | | OriGene shRNA RFP for PIK3C2B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PIK3C2B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PIK3C2B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PIK3C2B | | OriGene 3'-UTR Clone for PIK3C2B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3C2B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3C2B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PIK3C2B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PIK3C2B | | OriGene Custom Protein Services for PIK3C2B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PIK3C2B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PIK3C2B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIK3C2B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIK3C2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIK3C2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIK3C2B |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3C2B |
|  |  |  | | | | ThermoFisher Antibodies for PIK3C2B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3C2B |
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