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PIK3C2B Gene

protein-coding   GIFtS: 69
GCID: GC01M204391

Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit...

(Previous names: phosphoinositide-3-kinase, class 2, beta polypeptide)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2
Beta1 2
     PI3K-C2beta2
Phosphoinositide-3-Kinase, Class 2, Beta Polypeptide1 2     Phosphatidylinositol 3-Kinase C2 Domain-Containing Beta Polypeptide2
Phosphoinositide 3-Kinase-C2-Beta2 3     Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit
Beta2
PtdIns-3-Kinase C2 Subunit Beta2 3     Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing Subunit
Beta2
C2-PI3K2 3     PTDINS-3-Kinase C2 Beta2
PI3K-C2-beta2 3     EC 2.7.18
EC 2.7.1.1543 8     

External Ids:    HGNC: 89721   Entrez Gene: 52872   Ensembl: ENSG000001330567   OMIM: 6028385   UniProtKB: O007503   

Export aliases for PIK3C2B gene to outside databases

Previous GC identifers: GC01M202118 GC01M199852 GC01M200752 GC01M201569 GC01M201123 GC01M202658 GC01M202538 GC01M175556


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PIK3C2B Gene:
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in
signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and
intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal
C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding
motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions.
The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2
domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function
in a calcium-independent manner. (provided by RefSeq, Jul 2008)

GeneCards Summary for PIK3C2B Gene:
PIK3C2B (phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta) is a protein-coding gene. GO annotations related to this gene include 1-phosphatidylinositol-4-phosphate 3-kinase activity and phosphatidylinositol binding. An important paralog of this gene is PIK3CD.

UniProtKB/Swiss-Prot: P3C2B_HUMAN, O00750
Function: Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2.
May be involved in EGF and PDGF signaling cascades

summary for PIK3C2B Gene:
PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the
3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of
cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell
migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric
consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and
delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst
p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have
recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes
(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI
3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to
play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3C2B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PIK3C2B gene promoter:
         Elk-1   NF-AT   PPAR-alpha   MEF-2A   NF-AT4   NF-AT2   NF-AT3   aMEF-2   Pax-4a   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIK3C2B promoter sequence
   Search Chromatin IP Primers for PIK3C2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIK3C2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

PIK3C2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIK3C2B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M204391:  view genomic region     (about GC identifiers)

Start:
204,391,756 bp from pter      End:
204,463,852 bp from pter
Size:
72,097 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: P3C2B_HUMAN, O00750 (See protein sequence)
Recommended Name: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta  
Size: 1634 amino acids; 184768 Da
Cofactor: Calcium, magnesium, or manganese
Subunit: Part of a complex with ERBB2 and EGFR. Part of a complex with phosphorylated EGFR and GRB2. Interacts
with phosphorylated EGFR and PDGFR, maybe indirectly. Interacts with GRB2 and SHC1
Caution: It is uncertain whether Met-1 or Met-26 is the initiator
Sequence caution: Sequence=CAA74194.1; Type=Erroneous initiation;
Secondary accessions: O95666 Q5SW99

Explore the universe of human proteins at neXtProt for PIK3C2B: NX_O00750

Explore proteomics data for PIK3C2B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys12, Lys22, Lys70, Lys201, Lys241, Lys267, Lys752, Lys1027, Lys1047, Lys1152
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PIK3C2B (O00750) (see all 11)
     KRDRAPF  DLRQDML  DRHNDNIM  GVTGSFKD 


    See PIK3C2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002637.3  
    ENSEMBL proteins: 
     ENSP00000356155   ENSP00000356152   ENSP00000401795   ENSP00000409554   ENSP00000400561  
    Reactome Protein details: O00750

    PIK3C2B Human Recombinant Protein Products:

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    Novus Biologicals PIK3C2B Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PIK3C2B 

    PIK3C2B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    PIK3C2B Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for PIK3C2B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
    Phosphatidylinositol-4-phosphate 3-kinase family

    Selected InterPro protein domains (see all 10):
     IPR001263 PInositide-3_kin_accessory_dom
     IPR002420 PI3K_C2_dom
     IPR001683 Phox
     IPR011009 Kinase-like_dom
     IPR000403 PI3/4_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry O00750

    ProtoNet protein and cluster: O00750

    4 Blocks protein domains:
    IPB000008 C2 domain
    IPB000341 Phosphoinositide 3-kinase
    IPB000403 Phosphatidylinositol 3- and 4-kinase
    IPB001683 Phox-like


    UniProtKB/Swiss-Prot: P3C2B_HUMAN, O00750
    Similarity: Belongs to the PI3/PI4-kinase family
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 C2 PI3K-type domain
    Similarity: Contains 1 PI3K-RBD domain
    Similarity: Contains 1 PI3K/PI4K domain
    Similarity: Contains 1 PIK helical domain
    Similarity: Contains 1 PX (phox homology) domain


    Find genes that share domains with PIK3C2B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P3C2B_HUMAN, O00750
    Function: Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2.
    May be involved in EGF and PDGF signaling cascades
    Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol
    3,4-bisphosphate
    Enzyme regulation: Activated by GRB2

         Genatlas biochemistry entry for PIK3C2B:
    phosphatidylinositol 3-kinase,class 2,widely expressed

         Enzyme Numbers (IUBMB): EC 2.7.1.1541 2 EC 2.7.12

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001727lipid kinase activity IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI10805725
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
         
    Find genes that share ontologies with PIK3C2B           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for PIK3C2B:
     Decreased telomerase activity  Increased cilium length after   Increases Tamoxifen sensitivit 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pik3c2b):
     integument  no phenotypic analysis 

    Find genes that share phenotypes with PIK3C2B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pik3c2btm1.1Pkha for PIK3C2B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PIK3C2B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PIK3C2B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PIK3C2B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PIK3C2B

    miRNA
    Products:
        
    miRTarBase miRNAs that target PIK3C2B:
    hsa-mir-15b-5p (MIRT046415), hsa-mir-335-5p (MIRT018449), hsa-mir-128-3p (MIRT022049)

    Block miRNA regulation of human, mouse, rat PIK3C2B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PIK3C2B (see all 52):
    hsa-miR-579 hsa-miR-1197 hsa-miR-1258 hsa-miR-624 hsa-miR-138-2* hsa-miR-371-5p hsa-miR-650 hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidPIK3C2B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PIK3C2B
    Predesigned siRNA for gene silencing in human, mouse, rat PIK3C2B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PIK3C2B

    Clone
    Products:
         
    OriGene clones in human, mouse for PIK3C2B (see all 7)
    OriGene ORF clones in mouse, rat for PIK3C2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PIK3C2B (NM_002646)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3C2B

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3C2B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    P3C2B_HUMAN, O00750: Microsome. Cell membrane. Cytoplasm, cytosol. Nucleus. Endoplasmic reticulum. Note=Found
    mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endoplasmic reticulum5
    nucleus5
    plasma membrane5
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0005942phosphatidylinositol 3-kinase complex IBA--

    Find genes that share ontologies with PIK3C2B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PIK3C2B About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1PI Metabolism
    PI Metabolism0.65
    3-phosphoinositide biosynthesis0.47
    Synthesis of PIPs at the plasma membrane0.65
    2Inositol phosphate metabolism (KEGG)
    Inositol phosphate metabolism0.61
    superpathway of inositol phosphate compounds0.60
    Phosphatidylinositol signaling system0.61
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    4Sorafenib Pharmacodynamics
    Sorafenib Pharmacodynamics0.37
    VEGF Pathway0.36
    5Apoptosis Pathway
    Apoptosis Pathway0.45
    Akt Pathway0.39
    NF-kappaB Pathway0.45


    Find genes that share SuperPaths with PIK3C2B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for PIK3C2B
        TGF-beta Signaling Pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PIK3C2B
        ICos-ICosL Pathway in T-Helper Cell
    PI3K Signaling in B-Lymphocyte
    CD28 Signaling in T-Helper Cell

    Selected Tocris Bioscience Pathways for PIK3C2B (see all 9)
        Akt Pathway
    Insulin Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    Toll-like Receptor Pathway

    Selected BioSystems Pathways for PIK3C2B (see all 7)
        Signal Transduction of S1P Receptor
    EGFR1 Signaling Pathway
    Signaling Pathways in Glioblastoma
    Regulation of Actin Cytoskeleton
    3-phosphoinositide biosynthesis

    1 Reactome Pathway for PIK3C2B
        Synthesis of PIPs at the plasma membrane

    3 PharmGKB Pathways for PIK3C2B
        Proton Pump Inhibitor Pathway, Pharmacodynamics
    Sorafenib Pharmacodynamics
    VEGF Signaling Pathway

    3 Kegg Pathways  (Kegg details for PIK3C2B):
        Inositol phosphate metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system

        Pathway & Disease-focused RT2 Profiler PCR Array including PIK3C2B: 
              Diabetes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PIK3C2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PIK3C2B (O007501, 2, 3 ENSP000003561554) via UniProtKB, MINT, STRING, and/or I2D (see all 100)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046261, 3, ENSP000002695714EBI-641107,EBI-641062 I2D: score=3 STRING: ENSP00000269571
    PIK3R1P279862, 3, ENSP000002743354MINT-8112135 I2D: score=3 STRING: ENSP00000274335
    SFNP319472, 3MINT-3975518 I2D: score=2 
    YWHAZP631042, 3MINT-3307813 I2D: score=1 
    GRB2P629931, 3, ENSP000003390074EBI-641107,EBI-401755 I2D: score=6 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0008150biological_process ND--
    GO:0036092phosphatidylinositol-3-phosphate biosynthetic process IBA--
    GO:0043491protein kinase B signaling IEA--

    Find genes that share ontologies with PIK3C2B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for PIK3C2B
      Browse compounds at ApexBio 

    Compounds for PIK3C2B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CZC 24832Selective inhibitor of PI 3-Kinase gamma[1159824-67-5]
    QuercetinNon-selective PI 3-kinase inhibitor[117-39-5]
    PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK [371935-74-9]
    AS 605240Potent and selective PI 3-kinase gamma (PI3Kgamma) inhibitor[648450-29-7]
    740 Y-PCell-permeable PI 3-kinase activator[1236188-16-1]

    5 HMDB Compounds for PIK3C2B    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--

    3 Novoseek inferred chemical compound relationships for PIK3C2B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphoinositide 68.3 4 12573450 (1), 16857245 (1), 19496756 (1), 12372612 (1)
    phosphotyrosine 55.4 1 11533253 (1)
    lipid 24.3 2 19587117 (1), 19496756 (1)



    Find genes that share compounds with PIK3C2B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PIK3C2B gene: 
    NM_002646.3  

    Unigene Cluster for PIK3C2B:

    Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
    Hs.497487  [show with all ESTs]
    Unigene Representative Sequence: Y11312
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367187(uc001haw.3 uc010pqv.2 uc009xbd.1) ENST00000462752
    ENST00000479079 ENST00000496872 ENST00000367184 ENST00000415899 ENST00000429009
    ENST00000424712(uc001hax.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PIK3C2B (see all 52):
    hsa-miR-579 hsa-miR-1197 hsa-miR-1258 hsa-miR-624 hsa-miR-138-2* hsa-miR-371-5p hsa-miR-650 hsa-miR-105
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: PIK3C2B (NM_002646)
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      QuantiTect SYBR Green Assays in human, mouse, rat PIK3C2B
      QuantiFast Probe-based Assays in human, mouse, rat PIK3C2B

    Additional mRNA sequence: 

    AB210006.1 AK123366.1 AK308153.1 BC094741.1 BC132876.1 BC136645.1 BC144342.1 CR749201.1 
    Y11312.1 Y13892.1 

    11 DOTS entries:

    DT.91799809  DT.95361655  DT.314095  DT.101963247  DT.100680061  DT.91746004  DT.95121450  DT.91747213 
    DT.92072038  DT.91727756  DT.92414676 

    Selected AceView cDNA sequences (see all 87):

    CR749201 AA923518 BQ223607 AI061153 AA767504 AA494135 AW262807 AW009373 
    AA252181 AA770675 NM_002646 AA573474 AW054691 AI093064 AA808032 BX280568 
    BM678774 AI669305 AI139566 CR608190 CF994687 Y13892 BX451718 CB960034 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PIK3C2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGTTTAAA
    PIK3C2B Expression
    About this image


    PIK3C2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Eye (Sensory Organs)
             Lens
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
    PIK3C2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIK3C2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.497487

    UniProtKB/Swiss-Prot: P3C2B_HUMAN, O00750
    Tissue specificity: Expressed in columnar and transitional epithelia, mononuclear cells, and ganglion cells (at
    protein level). Widely expressed, with highest levels in thymus and placenta and lowest in peripheral blood,
    skeletal muscle and kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including PIK3C2B: 
              Diabetes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PIK3C2B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pik3c2b1 , 5 phosphoinositide-3-kinase, class 2, beta polypeptide1, 5 88.83(n)1
    93.75(a)1
      1 (57.75 cM)5
    2407521  NM_001099276.21  NP_001092746.21 
     1330456675 
    chicken
    (Gallus gallus)
    Aves PIK3C2B1 phosphoinositide-3-kinase, class 2, beta polypeptide 79.01(n)
    83.46(a)
      419822  XM_417956.4  XP_417956.3 
    lizard
    (Anolis carolinensis)
    Reptilia PIK3C2B6
    phosphatidylinositol-4-phosphate 3-kinase, catalyt...
    82(a)
    1 ↔ 1
    4(117432525-117536579)
    zebrafish
    (Danio rerio)
    Actinopterygii pik3c2b1 phosphoinositide-3-kinase, class 2, beta polypeptide 65.98(n)
    65.83(a)
      567938  XM_003199487.2  XP_003199535.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pi3K68D3 phosphorylation phosphatidylinositol
    3-kinase
    39(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea piki-16
    Protein PIKI-1 (piki-1) mRNA, complete cds
    26(a)
    1 → many
    X(15234832-15246365) WBGene00009552
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS346
    Phosphatidylinositol 3-kinase responsible for the ...
    21(a)
    1 → many
    XII(617533-620160) YLR240W


    ENSEMBL Gene Tree for PIK3C2B (if available)
    TreeFam Gene Tree for PIK3C2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PIK3C2B gene
    PIK3CD2  PIK3CA2  PIK3C2G2  PIK3CG2  PIK3C32  PIK3CB2  PIK3C2A2  
    16 SIMAP similar genes for PIK3C2B using alignment to 7 protein entries:     P3C2B_HUMAN (see all proteins):
    DKFZp686G16234    PIK3C2B variant protein    DOC2A    PIK3C2A    PRKCG    PIK3CB
    DKFZp779K1237    PIK3C3    PIK3C2G    CHR11SYT    SYT4    SYTL2
    PIK3CG    RIMS1    SYT1    PI4KB

    Find genes that share paralogs with PIK3C2B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PIK3C2B (see all 1708)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1445326681,2
    Cuntested1204438112(+) GCCACG/AGGTTT 2 /P syn11Minor allele frequency- A:0.00NA 4534
    rs1394305781,2
    --204391312(+) GCCCAG/TCCAAA 1 -- ds50010--------
    rs561746381,2
    C--204391371(+) CACCTA/GTAATC 1 -- ds50010--------
    rs120688761,2
    C,F--204391386(+) cacttC/Tgggag 1 -- ds50016Minor allele frequency- T:0.38NA WA CSA EA 129
    rs1809057511,2
    C--204391469(+) ACTAAA/GAATTA 1 -- ds50010--------
    rs617580251,2
    C,F--204391521(-) ACTCCT/CGGGCT 1 -- ds50012Minor allele frequency- C:0.04NS 76
    rs178477751,2
    C--204391849(-) GATCTA/GTGTAC 1 -- ut31 ese30--------
    rs617580241,2
    C,F--204391973(-) AGGAGG/CGGGAA 1 -- ut313Minor allele frequency- C:0.05NS WA 210
    rs1923176151,2
    --204392043(+) TGCCCC/TGTGGC 1 -- ut310--------
    rs1834267141,2
    --204392136(+) CAGTTC/TACAGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PIK3C2B (204391756 - 204463852 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for PIK3C2B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721895CNV Deletion23290073
    esv1350665CNV Deletion17803354
    esv2721873CNV Deletion23290073
    esv2721884CNV Deletion23290073
    esv2721851CNV Deletion23290073
    esv2721862CNV Deletion23290073
    nsv516276CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PIK3C2B
    DNA2.0 Custom Variant and Variant Library Synthesis for PIK3C2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602838    OMIM disorders: --


    Find genes that share disorders with PIK3C2B           About GenesLikeMe

    Genetic Association Database (GAD): PIK3C2B
    Human Genome Epidemiology (HuGE) Navigator: PIK3C2B (9 documents)

    Export disorders for PIK3C2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIK3C2B gene, integrated from 10 sources (see all 82):
    (articles sorted by number of sources associating them with PIK3C2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity. (PubMed id 9830063)1, 2, 3 Arcaro A.... Waterfield M.D. (J. Biol. Chem. 1998)
    2. Identification and cDNA cloning of a novel mammalian C2 domain- containing phosphoinositide 3-kinase, HsC2-PI3K. (PubMed id 9144573)1, 2, 3 Brown R.A.... Fry M.J. (Biochem. Biophys. Res. Commun. 1997)
    3. Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2. (PubMed id 11533253)1, 2, 9 Wheeler M. and Domin J. (Mol. Cell. Biol. 2001)
    4. Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. (PubMed id 10805725)1, 2, 9 Arcaro A....Domin J. (Mol. Cell. Biol. 2000)
    5. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer. (PubMed id 20197460)1, 4 Koutros S....Berndt S.I. (Cancer Res. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (Eur. J. Hum. Genet. 2009)
    10. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PubMed id 18996102)1, 4 RuaA+o G....Hanks S. ( international journal of clinical chemistry 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5287 HGNC: 8972 AceView: PIK3C2B Ensembl:ENSG00000133056 euGenes: HUgn5287
    ECgene: PIK3C2B Kegg: 5287 H-InvDB: PIK3C2B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PIK3C2B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PIK3C2B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PIK3C2B gene:
    Search GeneIP for patents involving PIK3C2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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