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Aliases for PIK3C2B Gene

Aliases for PIK3C2B Gene

  • Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta 2 3 5
  • Phosphoinositide-3-Kinase, Class 2, Beta Polypeptide 2 3
  • Phosphoinositide 3-Kinase-C2-Beta 3 4
  • PtdIns-3-Kinase C2 Subunit Beta 3 4
  • PI3K-C2-Beta 3 4
  • EC 2.7.1.154 4 61
  • C2-PI3K 3 4
  • Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit Beta 3
  • Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 Beta 2
  • Phosphatidylinositol 3-Kinase C2 Domain-Containing Beta Polypeptide 3
  • PTDINS-3-Kinase C2 Beta 3
  • PI3K-C2beta 3
  • EC 2.7.1 61

External Ids for PIK3C2B Gene

Previous GeneCards Identifiers for PIK3C2B Gene

  • GC01M202118
  • GC01M199852
  • GC01M200752
  • GC01M201569
  • GC01M201123
  • GC01M202658
  • GC01M202538
  • GC01M204391
  • GC01M175556

Summaries for PIK3C2B Gene

Entrez Gene Summary for PIK3C2B Gene

  • The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]

GeneCards Summary for PIK3C2B Gene

PIK3C2B (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta) is a Protein Coding gene. Among its related pathways are VEGF Signaling Pathway and Metabolism. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and kinase activity. An important paralog of this gene is PIK3C2A.

UniProtKB/Swiss-Prot for PIK3C2B Gene

  • Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.

Tocris Summary for PIK3C2B Gene

  • PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.

Gene Wiki entry for PIK3C2B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIK3C2B Gene

Genomics for PIK3C2B Gene

Regulatory Elements for PIK3C2B Gene

Enhancers for PIK3C2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F204460 1.5 FANTOM5 Ensembl ENCODE 24.4 +30.6 30551 7.5 ARID4B YY1 GATA2 DEK REST NFIL3 MEF2D SMARCA4 KDM1A CTCF PIK3C2B PPP1R15B LRRN2 SOX13 ZC3H11A
GH01F204445 1 Ensembl ENCODE 23.9 +44.7 44722 8.2 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF143 GYG2P2 MDM4 PIK3C2B SNRPE ZBED6 PPP1R15B RBBP5 PRELP
GH01F204441 0.2 ENCODE 23.5 +51.8 51813 3.8 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 PIK3C2B PPP1R15B ZBED6
GH01F204431 1.1 Ensembl ENCODE 23.3 +59.1 59121 9.3 PKNOX1 ARNT ZNF133 ARID4B SIN3A FEZF1 ZNF2 BRCA1 YY1 ZNF143 PIK3C2B PPP1R15B
GH01F204511 0.6 FANTOM5 ENCODE 18.2 -22.3 -22266 11.9 CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 MDM4 ZBED6 GYG2P2 SNRPE PPP1R15B PIK3C2B LOC101929459 ENSG00000236108 LOC105371691 RBBP5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PIK3C2B on UCSC Golden Path with GeneCards custom track

Promoters for PIK3C2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082269 315 2601 HDGF CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 KLF13

Genomic Location for PIK3C2B Gene

Chromosome:
1
Start:
204,422,628 bp from pter
End:
204,494,815 bp from pter
Size:
72,188 bases
Orientation:
Minus strand

Genomic View for PIK3C2B Gene

Genes around PIK3C2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIK3C2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIK3C2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIK3C2B Gene

Proteins for PIK3C2B Gene

  • Protein details for PIK3C2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00750-P3C2B_HUMAN
    Recommended name:
    Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
    Protein Accession:
    O00750
    Secondary Accessions:
    • O95666
    • Q5SW99

    Protein attributes for PIK3C2B Gene

    Size:
    1634 amino acids
    Molecular mass:
    184768 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Part of a complex with ERBB2 and EGFR. Part of a complex with phosphorylated EGFR and GRB2. Interacts with phosphorylated EGFR and PDGFR, maybe indirectly. Interacts with GRB2 and SHC1.
    SequenceCaution:
    • Sequence=CAA74194.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PIK3C2B Gene

Selected DME Specific Peptides for PIK3C2B Gene

O00750:
  • FTRLIESSLGS
  • FVDLCCQAYNLIRK
  • CDRHNDNIML
  • DRHNDNIM
  • KRDRAPF
  • EFQELHNKL
  • TSDMAYVINGG
  • DLRQDML
  • QRELQLSVLS
  • CVATYVLGI
  • GVTGSFKD

Post-translational modifications for PIK3C2B Gene

  • Ubiquitination at Lys 22, Lys 70, Lys 201, Lys 241, Lys 267, Lys 752, Lys 1027, Lys 1047, and Lys 1152
  • Modification sites at PhosphoSitePlus

Domains & Families for PIK3C2B Gene

Graphical View of Domain Structure for InterPro Entry

O00750

UniProtKB/Swiss-Prot:

P3C2B_HUMAN :
  • Contains 1 C2 domain.
  • Belongs to the PI3/PI4-kinase family.
Domain:
  • Contains 1 C2 domain.
  • Contains 1 C2 PI3K-type domain.
  • Contains 1 PI3K-RBD domain.
  • Contains 1 PI3K/PI4K domain.
  • Contains 1 PIK helical domain.
  • Contains 1 PX (phox homology) domain.
Family:
  • Belongs to the PI3/PI4-kinase family.
genes like me logo Genes that share domains with PIK3C2B: view

Function for PIK3C2B Gene

Molecular function for PIK3C2B Gene

GENATLAS Biochemistry:
phosphatidylinositol 3-kinase,class 2,widely expressed
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by GRB2.
UniProtKB/Swiss-Prot Function:
Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.

Enzyme Numbers (IUBMB) for PIK3C2B Gene

Gene Ontology (GO) - Molecular Function for PIK3C2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001727 lipid kinase activity IEA --
GO:0005515 protein binding IPI 10805725
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016303 1-phosphatidylinositol-3-kinase activity IBA --
genes like me logo Genes that share ontologies with PIK3C2B: view
genes like me logo Genes that share phenotypes with PIK3C2B: view

Animal Models for PIK3C2B Gene

MGI Knock Outs for PIK3C2B:

Animal Model Products

  • Taconic Biosciences Mouse Models for PIK3C2B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIK3C2B Gene

Localization for PIK3C2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIK3C2B Gene

Microsome. Cell membrane. Cytoplasm, cytosol. Nucleus. Endoplasmic reticulum. Note=Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIK3C2B Gene COMPARTMENTS Subcellular localization image for PIK3C2B gene
Compartment Confidence
cytosol 5
nucleus 4
endoplasmic reticulum 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for PIK3C2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol IEA,TAS --
genes like me logo Genes that share ontologies with PIK3C2B: view

Pathways & Interactions for PIK3C2B Gene

genes like me logo Genes that share pathways with PIK3C2B: view

SIGNOR curated interactions for PIK3C2B Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PIK3C2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0008150 biological_process ND --
GO:0009267 cellular response to starvation IEA --
GO:0016310 phosphorylation IEA --
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA --
genes like me logo Genes that share ontologies with PIK3C2B: view

Drugs & Compounds for PIK3C2B Gene

(25) Drugs for PIK3C2B Gene - From: DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Manganese Approved Nutra 34
3-Methyladenine Experimental Pharma Class III PI3K inhibitor, Class III PI 3-kinase inhibitor; also inhibits autophagy 0
SF1126 Investigational Pharma inhibitor Kinase Inhibitors 0
XL147 Investigational Pharma inhibitor PI3K inhibitor,selective and reversible, Kinase Inhibitors, Phosphatidylinositol-3- kinase (PI-3K) inhibitors 0

(5) Additional Compounds for PIK3C2B Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
LY 294002 hydrochloride
934389-88-5

(5) Tocris Compounds for PIK3C2B Gene

Compound Action Cas Number
3-Methyladenine Class III PI 3-kinase inhibitor; also inhibits autophagy 5142-23-4
740 Y-P Cell-permeable PI 3-kinase activator 1236188-16-1
LY 294002 hydrochloride Prototypical PI 3-kinase inhibitor; also inhibits other kinases 934389-88-5
PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK 371935-79-4
PI 828 PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130) 942289-87-4
genes like me logo Genes that share compounds with PIK3C2B: view

Transcripts for PIK3C2B Gene

Unigene Clusters for PIK3C2B Gene

Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIK3C2B Gene

No ASD Table

Relevant External Links for PIK3C2B Gene

GeneLoc Exon Structure for
PIK3C2B
ECgene alternative splicing isoforms for
PIK3C2B

Expression for PIK3C2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PIK3C2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PIK3C2B Gene

This gene is overexpressed in Serum (24.8), Plasma (16.3), and Testis (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PIK3C2B Gene



NURSA nuclear receptor signaling pathways regulating expression of PIK3C2B Gene:

PIK3C2B

SOURCE GeneReport for Unigene cluster for PIK3C2B Gene:

Hs.497487

mRNA Expression by UniProt/SwissProt for PIK3C2B Gene:

O00750-P3C2B_HUMAN
Tissue specificity: Expressed in columnar and transitional epithelia, mononuclear cells, and ganglion cells (at protein level). Widely expressed, with highest levels in thymus and placenta and lowest in peripheral blood, skeletal muscle and kidney.
genes like me logo Genes that share expression patterns with PIK3C2B: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for PIK3C2B Gene

Orthologs for PIK3C2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIK3C2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIK3C2B 34 35
  • 98.35 (n)
dog
(Canis familiaris)
Mammalia PIK3C2B 34 35
  • 91.15 (n)
cow
(Bos Taurus)
Mammalia PIK3C2B 34 35
  • 90.43 (n)
oppossum
(Monodelphis domestica)
Mammalia PIK3C2B 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pik3c2b 34 16 35
  • 88.83 (n)
rat
(Rattus norvegicus)
Mammalia Pik3c2b 34
  • 88.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PIK3C2B 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIK3C2B 34 35
  • 79.01 (n)
lizard
(Anolis carolinensis)
Reptilia PIK3C2B 35
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pik3c2b 34 35
  • 65.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pi3K68D 36 35
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea piki-1 35
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS34 35
  • 21 (a)
OneToMany
Species where no ortholog for PIK3C2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PIK3C2B Gene

ENSEMBL:
Gene Tree for PIK3C2B (if available)
TreeFam:
Gene Tree for PIK3C2B (if available)

Paralogs for PIK3C2B Gene

Paralogs for PIK3C2B Gene

genes like me logo Genes that share paralogs with PIK3C2B: view

Variants for PIK3C2B Gene

Sequence variations from dbSNP and Humsavar for PIK3C2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1002779 -- 204,435,970(+) CTCCC(A/T)GTCAC intron-variant
rs10047149 -- 204,423,425(+) cctgg(C/T)gacag nc-transcript-variant, utr-variant-3-prime
rs1008833 -- 204,457,167(+) GGACC(A/G)GAATG intron-variant
rs10494851 -- 204,489,038(-) AAAAA(A/G)TGTTC intron-variant
rs10494852 -- 204,488,658(-) ATCTC(A/G)CCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIK3C2B Gene

Variant ID Type Subtype PubMed ID
esv1350665 CNV deletion 17803354
esv2721851 CNV deletion 23290073
esv2721862 CNV deletion 23290073
esv2721873 CNV deletion 23290073
esv2721884 CNV deletion 23290073
esv2721895 CNV deletion 23290073
nsv516276 CNV loss 19592680

Variation tolerance for PIK3C2B Gene

Residual Variation Intolerance Score: 12.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.69; 66.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIK3C2B Gene

Human Gene Mutation Database (HGMD)
PIK3C2B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIK3C2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIK3C2B Gene

Disorders for PIK3C2B Gene

Relevant External Links for PIK3C2B

Genetic Association Database (GAD)
PIK3C2B
Human Genome Epidemiology (HuGE) Navigator
PIK3C2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIK3C2B

No disorders were found for PIK3C2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIK3C2B Gene

Publications for PIK3C2B Gene

  1. Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2. (PMID: 11533253) Wheeler M. … Domin J. (Mol. Cell. Biol. 2001) 3 4 22 64
  2. Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. (PMID: 10805725) Arcaro A. … Domin J. (Mol. Cell. Biol. 2000) 3 4 22 64
  3. Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity. (PMID: 9830063) Arcaro A. … Waterfield M.D. (J. Biol. Chem. 1998) 2 3 4 64
  4. Identification and cDNA cloning of a novel mammalian C2 domain- containing phosphoinositide 3-kinase, HsC2-PI3K. (PMID: 9144573) Brown R.A. … Fry M.J. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 64
  5. Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer. (PMID: 20197460) Koutros S. … Berndt S.I. (Cancer Res. 2010) 3 46 64

Products for PIK3C2B Gene

Sources for PIK3C2B Gene

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