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PIK3C2A Gene

protein-coding   GIFtS: 67
GCID: GC11M017099

Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit...

(Previous names: phosphoinositide-3-kinase, class 2, alpha polypeptide)
  See PIK3C2A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2
Alpha1 2
     PI3-K-C2(ALPHA)2
Phosphoinositide-3-Kinase, Class 2, Alpha Polypeptide1 2     PI3-K-C2A2
Phosphoinositide 3-Kinase-C2-Alpha2 3     PI3K-C2alpha2
PtdIns-3-Kinase C2 Subunit Alpha2 3     C2-Containing Phosphatidylinositol Kinase2
PI3K-C2-alpha2 3     Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit
Alpha2
EC 2.7.1.1543 8     Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing Subunit
Alpha2
CPK2     EC 2.7.18

External Ids:    HGNC: 89711   Entrez Gene: 52862   Ensembl: ENSG000000114057   OMIM: 6036015   UniProtKB: O004433   
ORGUL members:         

Export aliases for PIK3C2A gene to outside databases

Previous GC identifers: GC11M018181 GC11M018055 GC11M017147 GC11M017075 GC11M017064 GC11M017067 GC11M016791


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PIK3C2A Gene:
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in
signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and
intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal
C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding
motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions.
The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This
protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.
(provided by RefSeq, Jul 2008)

GeneCards Summary for PIK3C2A Gene:
PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha) is a protein-coding gene. Diseases associated with PIK3C2A include sine scleroderma, and wandering spleen. GO annotations related to this gene include 1-phosphatidylinositol-4-phosphate 3-kinase activity and phosphatidylinositol binding. An important paralog of this gene is PIK3C2B.

UniProtKB/Swiss-Prot: P3C2A_HUMAN, O00443
Function: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate
(PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions
in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the
plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion
through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in
a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of
insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin
signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates
dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells
synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth
muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent
phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be
involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and
function by supporting normal podocyte function

summary for PIK3C2A Gene:
PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the
3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of
cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell
migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric
consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and
delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst
p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have
recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes
(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI
3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to
play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

Gene Wiki entry for PIK3C2A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PIK3C2A gene promoter:
         C/EBPbeta   FOXF2   POU6F1 (c2)   Evi-1   HNF-1A   c-Rel   HNF-1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIK3C2A promoter sequence
   Search Chromatin IP Primers for PIK3C2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIK3C2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5-p14   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.5-p14

PIK3C2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIK3C2A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M017099:  view genomic region     (about GC identifiers)

Start:
17,099,277 bp from pter      End:
17,229,530 bp from pter
Size:
130,254 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: P3C2A_HUMAN, O00443 (See protein sequence)
Recommended Name: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha  
Size: 1686 amino acids; 190680 Da
Cofactor: Calcium or magnesium. Manganese cannot be used
Subunit: Part of a complex with ERBB2 and EGFR. Interacts with clathrin trimers
4 PDB 3D structures from and Proteopedia for PIK3C2A:
2AR5 (3D)        2IWL (3D)        2REA (3D)        2RED (3D)    
Secondary accessions: B0LPH2 Q14CQ9

Explore the universe of human proteins at neXtProt for PIK3C2A: NX_O00443

Explore proteomics data for PIK3C2A at MOPED

Post-translational modifications: 

  • Phosphorylated upon insulin stimulation; which may lead to enzyme activation (By similarity). Phosphorylated on
    Ser-259 during mitosis and upon UV irradiation; which does not change enzymatic activity but leads to proteasomal
    degradation. Ser-259 phosphorylation may be mediated by CDK1 or JNK, depending on the physiological state of the
    cell1
  • Ubiquitination2 at Lys229, Lys267
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PIK3C2A (O00443) (see all 11)
     KRDRAPF  DLRQDML  DRHNDNIM  GVTGSFKD 


    See PIK3C2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002636.2  
    ENSEMBL proteins: 
     ENSP00000265970   ENSP00000436244   ENSP00000436969   ENSP00000438687  
    Reactome Protein details: O00443

    PIK3C2A Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PIK3C2A Protein
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    OriGene Protein Over-expression Lysate for PIK3C2A
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PIK3C2A
    GenScript Custom Purified and Recombinant Proteins Services for PIK3C2A
    Novus Biologicals PIK3C2A Protein
    Novus Biologicals PIK3C2A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PIK3C2A 

    PIK3C2A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PIK3C2A
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    Novus Biologicals PIK3C2A Antibodies
    Abcam antibodies for PIK3C2A
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for PIK3C2A
    LSBio Antibodies in human, mouse, rat for PIK3C2A

    PIK3C2A Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for PIK3C2A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
    Phosphatidylinositol-4-phosphate 3-kinase family

    Selected InterPro protein domains (see all 10):
     IPR001263 PInositide-3_kin_accessory_dom
     IPR002420 PI3K_C2_dom
     IPR001683 Phox
     IPR011009 Kinase-like_dom
     IPR000403 PI3/4_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry O00443

    ProtoNet protein and cluster: O00443

    3 Blocks protein domains:
    IPB000008 C2 domain
    IPB000341 Phosphoinositide 3-kinase
    IPB000403 Phosphatidylinositol 3- and 4-kinase


    UniProtKB/Swiss-Prot: P3C2A_HUMAN, O00443
    Similarity: Belongs to the PI3/PI4-kinase family
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 C2 PI3K-type domain
    Similarity: Contains 1 PI3K-RBD domain
    Similarity: Contains 1 PI3K/PI4K domain
    Similarity: Contains 1 PIK helical domain
    Similarity: Contains 1 PX (phox homology) domain


    Find genes that share domains with PIK3C2A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P3C2A_HUMAN, O00443
    Function: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate
    (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions
    in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the
    plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion
    through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in
    a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of
    insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin
    signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates
    dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells
    synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth
    muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent
    phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be
    involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and
    function by supporting normal podocyte function
    Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol
    3,4-bisphosphate
    Enzyme regulation: Activated by insulin (By similarity). Only slightly inhibited by wortmannin and LY294002.
    Activated by clathrin
    Biophysicochemical properties: Kinetic parameters: KM=122 uM for PtdIns (in the absence of phosphatidylserine);
    KM=64 uM for PtdIns (in the presence of phosphatidylserine); KM=25 uM for PtdIns4P (in the presence of
    phosphatidylserine); KM=15 uM for ATP (with PtdIns as substrate) (in the absence of phosphatidylserine); KM=32 uM
    for ATP (with PtdIns as substrate) (in the presence of phosphatidylserine); KM=54 uM for ATP (with PtdIns4P as
    substrate) (in the presence of phosphatidylserine); Vmax=990 pmol/min/mg enzyme with PtdIns as substrate (in the
    absence of phosphatidylserine); Vmax=200 pmol/min/mg enzyme with PtdIns as substrate (in the presence of
    phosphatidylserine); Vmax=240 pmol/min/mg enzyme with PtdIns4P as substrate (in the presence of
    phosphatidylserine); Vmax=6800 pmol/min/mg enzyme toward ATP with PtdIns as substrate (in the absence of
    phosphatidylserine); Vmax=805 pmol/min/mg enzyme toward ATP with PtdIns as substrate (in the presence of
    phosphatidylserine); Vmax=880 pmol/min/mg enzyme toward ATP with PtdIns4P as substrate (in the presence of
    phosphatidylserine); Note=In the absence of the carrier phosphatidylserine, enzymatic kinetics toward PtdIns4P
    are non-linear;

         Enzyme Numbers (IUBMB): EC 2.7.1.1541 2 EC 2.7.12

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
    GO:00163031-phosphatidylinositol-3-kinase activity IBA--
         
    Find genes that share ontologies with PIK3C2A           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PIK3C2A:
     Decreased G3BP1 protein expres  Increased cell death HMECs cel 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pik3c2a):
     adipose tissue  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  renal/urinary system 

    Find genes that share phenotypes with PIK3C2A           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PIK3C2A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PIK3C2A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PIK3C2A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PIK3C2A

    miRNA
    Products:
        
    miRTarBase miRNAs that target PIK3C2A:
    hsa-mir-124-3p (MIRT022518), hsa-mir-182-5p (MIRT047215), hsa-let-7i-5p (MIRT046552), hsa-mir-335-5p (MIRT017588), hsa-mir-22-3p (MIRT030655), hsa-mir-21-5p (MIRT030824)

    Block miRNA regulation of human, mouse, rat PIK3C2A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PIK3C2A (see all 84):
    hsa-miR-3152-3p hsa-miR-15a hsa-miR-218-1* hsa-miR-1258 hsa-miR-371-5p hsa-miR-1244 hsa-miR-3148 hsa-miR-130b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: PIK3C2A (NM_002645)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3C2A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    P3C2A_HUMAN, O00443: Cell membrane. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus.
    Cytoplasm. Note=According to PubMed:10766823 and PubMed:11239472, it is found in the cell membrane, the Golgi
    apparatus and in clathrin-coated vesicles. According to PubMed:17038310 it inserts preferentially into membranes
    containing PtdIns(4,5)P2. According to PubMed:11606566, it is nuclear and cytoplasmic. Associated with
    RNA-containing structures. According to PubMed:14563213, it is mainly cytoplasmic
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    nucleus5
    plasma membrane5
    cytosol3
    cytoskeleton2
    endoplasmic reticulum2
    extracellular2
    mitochondrion2

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with PIK3C2A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PIK3C2A About   (see all 20)  
    See pathways by source

    SuperPathContained pathways About
    1PI Metabolism
    PI Metabolism0.65
    Synthesis of PIPs at the late endosome membrane0.00
    Synthesis of PIPs at the plasma membrane0.65
    Synthesis of PIPs at the Golgi membrane0.00
    3-phosphoinositide biosynthesis0.47
    Synthesis of PIPs at the early endosome membrane0.00
    2Inositol phosphate metabolism (KEGG)
    Inositol phosphate metabolism0.61
    superpathway of inositol phosphate compounds0.60
    Phosphatidylinositol signaling system0.61
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    4Sorafenib Pharmacodynamics
    Sorafenib Pharmacodynamics0.37
    VEGF Pathway0.36
    5Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    trans-Golgi Network Vesicle Budding0.89
    Golgi Associated Vesicle Biogenesis0.89
    Membrane Trafficking0.32


    Find genes that share SuperPaths with PIK3C2A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PIK3C2A
        ICos-ICosL Pathway in T-Helper Cell
    PI3K Signaling in B-Lymphocyte
    VEGF and S-1P Signaling
    CD28 Signaling in T-Helper Cell

    1 Cell Signaling Technology (CST) Pathway for PIK3C2A
        PI3K / Akt Signaling

    Selected Tocris Bioscience Pathways for PIK3C2A (see all 9)
        Akt Pathway
    Insulin Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    Toll-like Receptor Pathway

    Selected BioSystems Pathways for PIK3C2A (see all 6)
        Insulin Signaling
    Signaling Pathways in Glioblastoma
    Regulation of Actin Cytoskeleton
    3-phosphoinositide biosynthesis
    Integrins in angiogenesis

    5 Reactome Pathways for PIK3C2A
        Synthesis of PIPs at the plasma membrane
    Golgi Associated Vesicle Biogenesis
    Synthesis of PIPs at the late endosome membrane
    Synthesis of PIPs at the early endosome membrane
    Synthesis of PIPs at the Golgi membrane

    4 PharmGKB Pathways for PIK3C2A
        Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics
    Sorafenib Pharmacodynamics
    VEGF Signaling Pathway

    3 Kegg Pathways  (Kegg details for PIK3C2A):
        Inositol phosphate metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PIK3C2A: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Cancer Drug Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PIK3C2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PIK3C2A (O004432, 3 ENSP000002659704) via UniProtKB, MINT, STRING, and/or I2D (see all 509)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0006887exocytosis TAS17371240
    GO:0006897endocytosis IMP--
    GO:0007173epidermal growth factor receptor signaling pathway TAS17371240

    Find genes that share ontologies with PIK3C2A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for PIK3C2A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CZC 24832Selective inhibitor of PI 3-Kinase gamma[1159824-67-5]
    QuercetinNon-selective PI 3-kinase inhibitor[117-39-5]
    PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK [371935-74-9]
    AS 605240Potent and selective PI 3-kinase gamma (PI3Kgamma) inhibitor[648450-29-7]
    740 Y-PCell-permeable PI 3-kinase activator[1236188-16-1]

    Selected HMDB Compounds for PIK3C2A (see all 129)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    PS(14:0/14:0)Phosphatidylserine(14:0/14:0) (see all 7)----
    PS(14:0/14:1(9Z))Phosphatidylserine(14:0/14:1n5) (see all 13)----
    PS(14:0/16:0)1-myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine (see all 7)----
    PS(14:0/16:1(9Z))PS(14:0/16:1n7) (see all 13)----
    PS(14:0/18:0)Phosphatidylserine(32:0) (see all 7)----

    Selected Novoseek inferred chemical compound relationships for PIK3C2A gene (see all 106)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    creatinine 86.4 489 17300133 (3), 9501676 (3), 10522418 (2), 15518777 (2) (see all 99)
    dantrolene 60.5 3 2354060 (1), 9017254 (1), 8610025 (1)
    alpha-hydroxybutyrate 58.7 2 14761575 (1), 16824338 (1)
    fluvastatin 54.1 4 15518777 (1), 9203045 (1), 14872552 (1), 16446645 (1)
    lactate 52.2 62 16778757 (2), 12890994 (2), 11367646 (1), 9766526 (1) (see all 55)
    pravastatin 49.7 6 8591712 (3), 1733092 (1), 17532682 (1), 19104420 (1)
    simvastatin 48.3 6 11583721 (1), 1904357 (1), 12240878 (1), 8482062 (1) (see all 6)
    atorvastatin 46.7 5 12534315 (1), 12972104 (1), 17535079 (1), 18356785 (1)
    aspartate 45.4 29 14759379 (2), 14761575 (1), 17206443 (1), 2402132 (1) (see all 28)
    uric acid 44.9 28 17338197 (4), 9429015 (2), 14759379 (2), 1784405 (1) (see all 15)



    Find genes that share compounds with PIK3C2A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PIK3C2A gene: 
    NM_002645.2  

    Unigene Cluster for PIK3C2A:

    Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
    Hs.175343  [show with all ESTs]
    Unigene Representative Sequence: NM_002645
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531428(uc009ygu.1) ENST00000265970(uc001mmq.4 uc010rcw.2 uc010rcx.1 uc009ygv.1)
    ENST00000533645(uc001mmr.3) ENST00000532035 ENST00000503729 ENST00000540361

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    hsa-miR-3152-3p hsa-miR-15a hsa-miR-218-1* hsa-miR-1258 hsa-miR-371-5p hsa-miR-1244 hsa-miR-3148 hsa-miR-130b
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    Additional mRNA sequence: 

    AK294416.1 AK299474.1 AK304262.1 AK309610.1 AK310248.1 AL049998.1 AL832699.1 BC031681.1 
    BC040952.1 BC113658.1 BX648778.1 CR627335.1 Y13367.1 

    9 DOTS entries:

    DT.412738  DT.101973514  DT.437411  DT.101980888  DT.120715322  DT.91646588  DT.100784357  DT.100888938 
    DT.121502290 

    Selected AceView cDNA sequences (see all 179):

    BG548448 AV682436 BU679326 BQ723761 CA867091 AA026438 CA867231 AA344473 
    BX099044 AI811319 AI610239 CA774510 AA810622 AI954464 BE550883 AA348462 
    AI264571 AW675279 AW471240 AI648627 AI476460 AL706251 CA867165 BQ016976 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PIK3C2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTTTGACT
    PIK3C2A Expression
    About this image

    PIK3C2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIK3C2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.175343

    UniProtKB/Swiss-Prot: P3C2A_HUMAN, O00443
    Tissue specificity: Expressed in columnar and transitional epithelia, mononuclear cells, smooth muscle cells, and
    endothelial cells lining capillaries and small venules (at protein level). Ubiquitously expressed, with highest
    levels in heart, placenta and ovary, and lowest levels in the kidney. Detected at low levels in islets of
    Langerhans from type 2 diabetes mellitus individuals

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PIK3C2A: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Cancer Drug Targets in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PIK3C2A gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pik3c2a1 , 5 phosphatidylinositol 3-kinase, C2 domain containing, more1, 5 89.71(n)1
    90.32(a)1
      7 (61.62 cM)5
    187041  NM_011083.21  NP_035213.21 
     1163372765 
    chicken
    (Gallus gallus)
    Aves PIK3C2A1 phosphoinositide-3-kinase, class 2, alpha polypeptide 75.65(n)
    76.13(a)
      423070  XM_421003.3  XP_421003.2 
    lizard
    (Anolis carolinensis)
    Reptilia PIK3C2A6
    phosphatidylinositol-4-phosphate 3-kinase, catalyt...
    73(a)
    1 ↔ 1
    1(66632086-66675396)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.145862 Xenopus laevis transcribed sequence with moderate similarity more 74.81(n)    CA794192.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BG728812.12   -- 76.03(n)    BG728812.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pi3K68D1 , 3 phosphorylation phosphatidylinositol
    3-kinase3
    Phosphotidylinositol 3 kinase 68D1
    36(a)3
    48.34(n)1
    40.25(a)1
      393291  NM_079304.41  NP_524028.21 
    worm
    (Caenorhabditis elegans)
    Secernentea piki-11 piki-1 44.87(n)
    33.74(a)
      181618  NM_078128.3  NP_510529.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS346
    Phosphatidylinositol 3-kinase responsible for the ...
    22(a)
    1 → many
    XII(617533-620160) YLR240W


    ENSEMBL Gene Tree for PIK3C2A (if available)
    TreeFam Gene Tree for PIK3C2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PIK3C2A gene
    PIK3C2B2  PIK3CD2  PIK3CA2  PIK3C2G2  PIK3CG2  PIK3C32  PIK3CB2  
    12 SIMAP similar genes for PIK3C2A using alignment to 5 protein entries:     P3C2A_HUMAN (see all proteins):
    DKFZp686G16234    PIK3C2B variant protein    PIK3C2B    DKFZp779K1237    CHR11SYT    SYTL2
    PIK3CG    PIK3C3    PIK3CB    PIK3C2G    PIK3CD    SYT15

    Find genes that share paralogs with PIK3C2A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PIK3C2A (see all 1722)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1905998601,2
    --17107634(+) AGGAAC/TTGCTC 1 -- int10--------
    rs19876941,2
    C,F,A,H--17107648(+) gggggG/Cgctcg 1 -- int18Minor allele frequency- C:0.30NS EA NA 658
    rs601334521,2
    C--17107699(+) ACCCCA/TTCCTT 1 -- int10--------
    rs71264091,2
    C,F--17107756(+) taaaaA/Ttacaa 1 -- int12Minor allele frequency- T:0.19WA 120
    rs1493563321,2
    --17107770(+) TTAGCC/TGGGCG 1 -- int10--------
    rs110241521,2
    C,A--17107816(+) AGCTGA/GGGCAG 1 -- int10--------
    rs1384845261,2
    --17107887(+) CCAGGC/TCTGGG 1 -- int10--------
    rs1429059331,2
    --17107909(+) GACTCG/TGTCTC 1 -- int10--------
    rs758725851,2
    --17107914(+) TGTCTC/AAAAAA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1120972521,2
    C--17107914(+) AAAAA-/AGAGTT 1 -- int11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for PIK3C2A (17099277 - 17229530 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PIK3C2A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677594CNV Deletion23128226
    nsv7691CNV Loss18451855
    nsv467711CNV Gain19166990
    nsv469762CNV Complex16826518

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603601    OMIM disorders: --

    Selected diseases for PIK3C2A (see all 33):    
    About MalaCards
    sine scleroderma    wandering spleen    trichinosis    amyopathic dermatomyositis
    silent myocardial infarction    vibrio vulnificus infection    acute febrile neutrophilic dermatosis    inferior myocardial infarction
    autoimmune hypoparathyroidism    scleromyxedema    creatine phosphokinase, elevated serum    erysipelas
    acute kidney failure    bronchiolitis obliterans organizing pneumonia    necrotizing fasciitis    legionnaires' disease
    adult dermatomyositis    gas gangrene    nephropathia epidemica    intermediate coronary syndrome

    12 diseases from the University of Copenhagen DISEASES database for PIK3C2A:
    Myocardial infarction     Myopathy     Malignant hyperthermia     Vascular disease
    Neuropathy     Kidney failure     Gas gangrene     Intermediate coronary syndrome
    Pneumonia     Hypothyroidism     Dermatitis     Trichinosis

    Find genes that share disorders with PIK3C2A           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PIK3C2A gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    creatine phosphokinase, elevated serum 86.7 13 15925432 (1), 1803046 (1), 1398197 (1), 16553491 (1) (see all 12)
    rhabdomyolysis 86.6 51 17571610 (2), 10401940 (2), 17884958 (2), 9757925 (2) (see all 41)
    polymyositis 77.2 7 1464989 (1), 7536446 (1), 7564001 (1), 10614168 (1) (see all 7)
    neuroleptic malignant syndrome 74.8 4 20159196 (1), 1362345 (1), 17214072 (1), 10820583 (1)
    dermatomyositis 72.4 4 12355862 (1), 10614168 (1), 2244255 (1), 10496106 (1)
    myositis 71.2 15 10638867 (1), 18320790 (1), 1803046 (1), 10426928 (1) (see all 14)
    myopathy 70.2 30 15453946 (3), 2082493 (3), 9658790 (2), 18320790 (1) (see all 21)
    acute myocardial infarction 70.1 32 1842714 (2), 15815362 (2), 9778551 (1), 10522418 (1) (see all 24)
    renal failure acute 68 12 10365541 (1), 1848151 (1), 1477759 (1), 14717236 (1) (see all 11)
    myocardial infarction 63.8 28 17059151 (3), 9163005 (2), 19627702 (2), 10663915 (1) (see all 23)

    Genetic Association Database (GAD): PIK3C2A
    Human Genome Epidemiology (HuGE) Navigator: PIK3C2A (8 documents)

    Export disorders for PIK3C2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIK3C2A gene, integrated from 10 sources (see all 684):
    (articles sorted by number of sources associating them with PIK3C2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a human phosphoinositide 3-kinase with a C2 domain which displays reduced sensitivity to the inhibitor wortmannin. (PubMed id 9337861)1, 2, 3 Domin J.... Waterfield M.D. (Biochem. J. 1997)
    2. Individual phosphoinositide 3-kinase C2alpha domain activities independently regulate clathrin function. (PubMed id 16215232)1, 2, 9 Gaidarov I.... Keen J.H. (J. Biol. Chem. 2005)
    3. Structural and membrane binding analysis of the Phox homology domain of phosphoinositide 3-kinase-C2alpha. (PubMed id 17038310)1, 2, 9 Stahelin R.V.... Cho W. (J. Biol. Chem. 2006)
    4. Phosphatidylinositol 3-kinase c2alpha contains a nuclear localization sequence and associates with nuclear speckles. (PubMed id 11606566)1, 2, 9 Didichenko S.A. and Thelen M. (J. Biol. Chem. 2001)
    5. Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. (PubMed id 10805725)1, 2, 9 Arcaro A....Domin J. (Mol. Cell. Biol. 2000)
    6. Genome-wide association study identifies five new schizophrenia loci. (PubMed id 21926974)1, 4 (Nat. Genet. 2011)
    7. Absence of hotspot mutations in exons 9 and 20 of the PIK3CA gene in human oral squamous cell carcinoma in the Greek population. (PubMed id 20416519)1, 4 Kostakis G.C....Alexandridis C. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer. (PubMed id 20197460)1, 4 Koutros S....Berndt S.I. (Cancer Res. 2010)
    10. PI3KC2alpha, a class II PI3K, is required for dynamin-independent internalization pathways. (PubMed id 21081650)1, 2 Krag C.... Salcini A.E. (J. Cell Sci. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5286 HGNC: 8971 AceView: PIK3C2A Ensembl:ENSG00000011405 euGenes: HUgn5286
    ECgene: PIK3C2A Kegg: 5286 H-InvDB: PIK3C2A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PIK3C2A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PIK3C2A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PIK3C2A gene:
    Search GeneIP for patents involving PIK3C2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Browse ESI BIO Cell Lines and PureStem Progenitors for PIK3C2A
     Gene Synthesis
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     Codon Optimization
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3C2A
     Browse SwitchGear 3'UTR luciferase reporter plasmids for PIK3C2A
     SwitchGear Promoter luciferase reporter plasmids for PIK3C2A
     ThermoFisher Antibodies for PIK3C2A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3C2A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PIK3C2A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PIK3C2A
     LSBio Antibodies in human, mouse, rat for PIK3C2A
    Customized transgenic rodents for:
     Humanization
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     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for PIK3C2A
      Search eBioscience for proteins for PIK3C2A
      Search eBioscience for elisas for PIK3C2A
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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