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Aliases for PIK3C2A Gene

Aliases for PIK3C2A Gene

  • Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha 2 3 5
  • Phosphoinositide-3-Kinase, Class 2, Alpha Polypeptide 2 3
  • Phosphoinositide 3-Kinase-C2-Alpha 3 4
  • PtdIns-3-Kinase C2 Subunit Alpha 3 4
  • PI3K-C2-Alpha 3 4
  • EC 2.7.1.154 4 58
  • Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit Alpha 3
  • Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing Subunit Alpha 3
  • Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 Alpha 2
  • C2-Containing Phosphatidylinositol Kinase 3
  • PI3-K-C2(ALPHA) 3
  • PI3K-C2alpha 3
  • PI3-K-C2A 3
  • EC 2.7.1 58
  • CPK 3

External Ids for PIK3C2A Gene

Previous GeneCards Identifiers for PIK3C2A Gene

  • GC11M018181
  • GC11M018055
  • GC11M017147
  • GC11M017075
  • GC11M017064
  • GC11M017067
  • GC11M016791
  • GC11M017099
  • GC11M017083
  • GC11M017084
  • GC11M017089
  • GC11M017102
  • GC11M017106
  • GC11M017110

Summaries for PIK3C2A Gene

Entrez Gene Summary for PIK3C2A Gene

  • The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]

GeneCards Summary for PIK3C2A Gene

PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha) is a Protein Coding gene. Diseases associated with PIK3C2A include Acute Kidney Failure and Status Asthmaticus. Among its related pathways are Type II diabetes mellitus and Metabolism. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and phosphotransferase activity, alcohol group as acceptor. An important paralog of this gene is PIK3C2B.

UniProtKB/Swiss-Prot for PIK3C2A Gene

  • Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function.

Tocris Summary for PIK3C2A Gene

  • PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.

Gene Wiki entry for PIK3C2A Gene

Additional gene information for PIK3C2A Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIK3C2A Gene

Genomics for PIK3C2A Gene

Regulatory Elements for PIK3C2A Gene

Enhancers for PIK3C2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H017207 1.4 FANTOM5 ENCODE 12.7 -0.6 -643 4 HDGF FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF143 OR7E14P SAAL1 SNORD14A PIK3C2A C11orf58 RPL36AP37 RPS13 SNORD14B RPS2P40 GC11P017211
GH11H016381 0.6 ENCODE 4.9 +825.1 825080 2 TCF12 TAL1 HMBOX1 ZMYM3 FOS MLLT1 TAF7 PIK3C2A GC11P016359 GC11M016482
GH11H017196 0.8 ENCODE 0.4 +10.4 10430 1 ELF3 SOX13 FOXA2 SAP130 JUN ARID4B ZNF316 SMARCC2 ATF7 CREM OR7E14P RPS13 SNORD14B RPL29P21 PIK3C2A
GH11H017206 0.2 Ensembl 0.7 +1.9 1896 0 OR7E14P RPS13 SNORD14B PIK3C2A RPL29P21
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PIK3C2A on UCSC Golden Path with GeneCards custom track

Promoters for PIK3C2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000037492 196 2401 HDGF FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF143

Genomic Location for PIK3C2A Gene

Chromosome:
11
Start:
17,077,730 bp from pter
End:
17,207,996 bp from pter
Size:
130,267 bases
Orientation:
Minus strand

Genomic View for PIK3C2A Gene

Genes around PIK3C2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIK3C2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIK3C2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIK3C2A Gene

Proteins for PIK3C2A Gene

  • Protein details for PIK3C2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00443-P3C2A_HUMAN
    Recommended name:
    Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
    Protein Accession:
    O00443
    Secondary Accessions:
    • B0LPH2
    • B4E2G4
    • Q14CQ9

    Protein attributes for PIK3C2A Gene

    Size:
    1686 amino acids
    Molecular mass:
    190680 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Part of a complex with ERBB2 and EGFR. Interacts with clathrin trimers.

    Three dimensional structures from OCA and Proteopedia for PIK3C2A Gene

    Alternative splice isoforms for PIK3C2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIK3C2A Gene

Selected DME Specific Peptides for PIK3C2A Gene

O00443:
  • FTRLIESSLGS
  • FVDLCCQAYNLIRK
  • CDRHNDNIML
  • DRHNDNIM
  • KRDRAPF
  • EFQELHNKL
  • TSDMAYVINGG
  • DLRQDML
  • QRELQLSVLS
  • CVATYVLGI
  • GVTGSFKD

Post-translational modifications for PIK3C2A Gene

  • Phosphorylated upon insulin stimulation; which may lead to enzyme activation (By similarity). Phosphorylated on Ser-259 during mitosis and upon UV irradiation; which does not change enzymatic activity but leads to proteasomal degradation. Ser-259 phosphorylation may be mediated by CDK1 or JNK, depending on the physiological state of the cell.
  • Ubiquitination at posLast=229229 and posLast=267267
  • Modification sites at PhosphoSitePlus

Other Protein References for PIK3C2A Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PIK3C2A (PIK3C2A)

Domains & Families for PIK3C2A Gene

Graphical View of Domain Structure for InterPro Entry

O00443

UniProtKB/Swiss-Prot:

P3C2A_HUMAN :
  • Belongs to the PI3/PI4-kinase family.
Family:
  • Belongs to the PI3/PI4-kinase family.
genes like me logo Genes that share domains with PIK3C2A: view

Function for PIK3C2A Gene

Molecular function for PIK3C2A Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=122 uM for PtdIns (in the absence of phosphatidylserine) {ECO:0000269 PubMed:9337861}; KM=64 uM for PtdIns (in the presence of phosphatidylserine) {ECO:0000269 PubMed:9337861}; KM=25 uM for PtdIns4P (in the presence of phosphatidylserine) {ECO:0000269 PubMed:9337861}; KM=15 uM for ATP (with PtdIns as substrate) (in the absence of phosphatidylserine) {ECO:0000269 PubMed:9337861}; KM=32 uM for ATP (with PtdIns as substrate) (in the presence of phosphatidylserine) {ECO:0000269 PubMed:9337861}; KM=54 uM for ATP (with PtdIns4P as substrate) (in the presence of phosphatidylserine) {ECO:0000269 PubMed:9337861}; Vmax=990 pmol/min/mg enzyme with PtdIns as substrate (in the absence of phosphatidylserine) {ECO:0000269 PubMed:9337861}; Vmax=200 pmol/min/mg enzyme with PtdIns as substrate (in the presence of phosphatidylserine) {ECO:0000269 PubMed:9337861}; Vmax=240 pmol/min/mg enzyme with PtdIns4P as substrate (in the presence of phosphatidylserine) {ECO:0000269 PubMed:9337861}; Vmax=6800 pmol/min/mg enzyme toward ATP with PtdIns as substrate (in the absence of phosphatidylserine) {ECO:0000269 PubMed:9337861}; Vmax=805 pmol/min/mg enzyme toward ATP with PtdIns as substrate (in the presence of phosphatidylserine) {ECO:0000269 PubMed:9337861}; Vmax=880 pmol/min/mg enzyme toward ATP with PtdIns4P as substrate (in the presence of phosphatidylserine) {ECO:0000269 PubMed:9337861}; Note=In the absence of the carrier phosphatidylserine, enzymatic kinetics toward PtdIns4P are non-linear.;
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by insulin (By similarity). Only slightly inhibited by wortmannin and LY294002. Activated by clathrin.
UniProtKB/Swiss-Prot Function:
Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function.

Enzyme Numbers (IUBMB) for PIK3C2A Gene

Phenotypes From GWAS Catalog for PIK3C2A Gene

Gene Ontology (GO) - Molecular Function for PIK3C2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016303 1-phosphatidylinositol-3-kinase activity TAS 9337861
GO:0016740 transferase activity IEA --
GO:0035004 phosphatidylinositol 3-kinase activity TAS 17371240
genes like me logo Genes that share ontologies with PIK3C2A: view
genes like me logo Genes that share phenotypes with PIK3C2A: view

Animal Models for PIK3C2A Gene

MGI Knock Outs for PIK3C2A:

Animal Model Products

  • Taconic Biosciences Mouse Models for PIK3C2A

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PIK3C2A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIK3C2A Gene

Localization for PIK3C2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIK3C2A Gene

Cell membrane. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Cytoplasm. Note=Inserts preferentially into membranes containing PtdIns(4,5)P2 (PubMed:17038310). Associated with RNA-containing structures (PubMed:11606566). {ECO:0000269 PubMed:11606566, ECO:0000269 PubMed:17038310}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIK3C2A gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 5
golgi apparatus 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PIK3C2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA,IDA 21081650
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PIK3C2A: view

Pathways & Interactions for PIK3C2A Gene

genes like me logo Genes that share pathways with PIK3C2A: view

SIGNOR curated interactions for PIK3C2A Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PIK3C2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0006887 exocytosis TAS 17371240
GO:0006897 endocytosis IMP 21081650
GO:0007173 epidermal growth factor receptor signaling pathway TAS 17371240
GO:0008286 insulin receptor signaling pathway TAS 17371240
genes like me logo Genes that share ontologies with PIK3C2A: view

Drugs & Compounds for PIK3C2A Gene

(88) Drugs for PIK3C2A Gene - From: DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 35
3-Methyladenine Experimental Pharma Class III PI3K inhibitor, Class III PI 3-kinase inhibitor; also inhibits autophagy 0
SF1126 Investigational Pharma inhibitor Kinase Inhibitors 0
ATP Nutra Agonist 0
calcium Nutra 0

(165) Additional Compounds for PIK3C2A Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
PS(14:0/14:0)
  • 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:0)
  • Phosphatidylserine(28:0)
  • PS(14:0/14:0)
  • PS(28:0)
PS(14:0/14:1(9Z))
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:1)
  • Phosphatidylserine(14:0/14:1n5)
  • Phosphatidylserine(14:0/14:1w5)
  • Phosphatidylserine(28:1)
PS(14:0/16:0)
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:0)
  • Phosphatidylserine(30:0)
  • PS(14:0/16:0)
  • PS(30:0)
PS(14:0/16:1(9Z))
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:1)
  • Phosphatidylserine(14:0/16:1n7)
  • Phosphatidylserine(14:0/16:1w7)
  • Phosphatidylserine(30:1)

(5) Tocris Compounds for PIK3C2A Gene

Compound Action Cas Number
3-Methyladenine Class III PI 3-kinase inhibitor; also inhibits autophagy 5142-23-4
740 Y-P Cell-permeable PI 3-kinase activator 1236188-16-1
LY 294002 hydrochloride Prototypical PI 3-kinase inhibitor; also inhibits other kinases 934389-88-5
PI 103 hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK 371935-79-4
PI 828 PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130) 942289-87-4
genes like me logo Genes that share compounds with PIK3C2A: view

Transcripts for PIK3C2A Gene

Unigene Clusters for PIK3C2A Gene

Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PIK3C2A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PIK3C2A Gene

No ASD Table

Relevant External Links for PIK3C2A Gene

GeneLoc Exon Structure for
PIK3C2A
ECgene alternative splicing isoforms for
PIK3C2A

Expression for PIK3C2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PIK3C2A Gene

Protein differential expression in normal tissues from HIPED for PIK3C2A Gene

This gene is overexpressed in Plasma (14.4), Placenta (9.8), and Testis (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PIK3C2A Gene



Protein tissue co-expression partners for PIK3C2A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PIK3C2A Gene:

PIK3C2A

SOURCE GeneReport for Unigene cluster for PIK3C2A Gene:

Hs.175343

mRNA Expression by UniProt/SwissProt for PIK3C2A Gene:

O00443-P3C2A_HUMAN
Tissue specificity: Expressed in columnar and transitional epithelia, mononuclear cells, smooth muscle cells, and endothelial cells lining capillaries and small venules (at protein level). Ubiquitously expressed, with highest levels in heart, placenta and ovary, and lowest levels in the kidney. Detected at low levels in islets of Langerhans from type 2 diabetes mellitus individuals.

Evidence on tissue expression from TISSUES for PIK3C2A Gene

  • Liver(4.6)
  • Lung(4.5)
  • Heart(3.6)
  • Muscle(3.6)
  • Nervous system(3.2)
  • Blood(3)
  • Kidney(2.9)
  • Thyroid gland(2.4)
  • Skin(2.2)
  • Intestine(2)
  • Urine(2)
genes like me logo Genes that share expression patterns with PIK3C2A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIK3C2A Gene

Orthologs for PIK3C2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIK3C2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIK3C2A 33 34
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia PIK3C2A 33 34
  • 92.98 (n)
cow
(Bos Taurus)
Mammalia PIK3C2A 33 34
  • 91.88 (n)
mouse
(Mus musculus)
Mammalia Pik3c2a 33 16 34
  • 89.71 (n)
rat
(Rattus norvegicus)
Mammalia Pik3c2a 33
  • 89.42 (n)
oppossum
(Monodelphis domestica)
Mammalia PIK3C2A 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIK3C2A 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIK3C2A 33 34
  • 75.65 (n)
lizard
(Anolis carolinensis)
Reptilia PIK3C2A 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pik3c2a 33
  • 65.11 (n)
Str.7067 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.14586 33
zebrafish
(Danio rerio)
Actinopterygii pik3c2a 33 34
  • 63.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pi3K68D 35 33 34
  • 48.34 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011036 33
  • 46.16 (n)
worm
(Caenorhabditis elegans)
Secernentea piki-1 33 34
  • 44.87 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS34 34
  • 22 (a)
OneToMany
Species where no ortholog for PIK3C2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIK3C2A Gene

ENSEMBL:
Gene Tree for PIK3C2A (if available)
TreeFam:
Gene Tree for PIK3C2A (if available)

Paralogs for PIK3C2A Gene

Paralogs for PIK3C2A Gene

genes like me logo Genes that share paralogs with PIK3C2A: view

Variants for PIK3C2A Gene

Sequence variations from dbSNP and Humsavar for PIK3C2A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000018543 -- 17,183,647(+) CTGCA(C/T)TCCAG intron-variant
rs1000035288 -- 17,097,841(+) CCCAG(A/G)AGGAA intron-variant
rs1000045384 -- 17,162,082(+) TGTCA(A/T)CCCAG intron-variant
rs1000089177 -- 17,136,961(+) CCACA(C/T)TGAAA intron-variant
rs1000109712 -- 17,181,734(+) AAAAA(C/T)ATGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIK3C2A Gene

Variant ID Type Subtype PubMed ID
esv2677594 CNV deletion 23128226
esv3625466 CNV loss 21293372
nsv467711 CNV gain 19166990
nsv469762 CNV gain 16826518
nsv477831 CNV novel sequence insertion 20440878
nsv553567 CNV gain 21841781
nsv553568 CNV gain 21841781
nsv7691 CNV deletion 18451855
nsv971989 CNV duplication 23825009

Variation tolerance for PIK3C2A Gene

Residual Variation Intolerance Score: 7.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.61; 72.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIK3C2A Gene

Human Gene Mutation Database (HGMD)
PIK3C2A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIK3C2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIK3C2A Gene

Disorders for PIK3C2A Gene

MalaCards: The human disease database

(82) MalaCards diseases for PIK3C2A Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute kidney failure
  • renal failure acute
status asthmaticus
  • asthma with status asthmaticus
leptospirosis
  • fort bragg fever
neuroleptic malignant syndrome
inferior myocardial infarction
  • inferior myocardial infarction nos
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PIK3C2A

Genetic Association Database (GAD)
PIK3C2A
Human Genome Epidemiology (HuGE) Navigator
PIK3C2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIK3C2A
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No data available for UniProtKB/Swiss-Prot and Genatlas for PIK3C2A Gene

Publications for PIK3C2A Gene

  1. Structural and membrane binding analysis of the Phox homology domain of phosphoinositide 3-kinase-C2alpha. (PMID: 17038310) Stahelin RV … Cho W (The Journal of biological chemistry 2006) 3 4 22 60
  2. Individual phosphoinositide 3-kinase C2alpha domain activities independently regulate clathrin function. (PMID: 16215232) Gaidarov I … Keen JH (The Journal of biological chemistry 2005) 3 4 22 60
  3. Phosphatidylinositol 3-kinase c2alpha contains a nuclear localization sequence and associates with nuclear speckles. (PMID: 11606566) Didichenko SA … Thelen M (The Journal of biological chemistry 2001) 3 4 22 60
  4. Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. (PMID: 10805725) Arcaro A … Domin J (Molecular and cellular biology 2000) 3 4 22 60
  5. Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin. (PMID: 9337861) Domin J … Waterfield MD (The Biochemical journal 1997) 2 3 4 60

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Sources for PIK3C2A Gene

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