PIK3C2A Gene
protein-coding GIFtS: 61
GCID: GC11M017099
|
|
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit...(Previous names: phosphoinositide-3-kinase, class 2, alpha polypeptide )
| |
Aliases
for PIK3C2A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2Alpha1 2 | | CPK2 | | PI3K-C2alpha1 2 | | PI3-K-C2(ALPHA)2 | | Phosphoinositide-3-Kinase, Class 2, Alpha Polypeptide1 2 | | PI3-K-C2A2 | | Phosphoinositide 3-Kinase-C2-Alpha2 3 | | C2-Containing Phosphatidylinositol Kinase2 | | PtdIns-3-Kinase C2 Subunit Alpha2 3 | | Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit Alpha2 | | PI3K-C2-Alpha1 | | Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing Subunit Alpha2 | | EC 2.7.1.1543 8 | | EC 2.7.18 |
Export aliases for PIK3C2A gene to outside databasesPrevious GC identifers: GC11M018181 GC11M018055 GC11M017147 GC11M017075 GC11M017064 GC11M017067 GC11M016791 |
Summaries
for PIK3C2A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PIK3C2A:
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles insignaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, andintracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs thatmediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinaseactivity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to beable to be activated by insulin and may be involved in integrin-dependent signaling. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: P3C2A_HUMAN, O00443Function: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate(PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions ininsulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasmamembrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through twodifferent mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway thatinvolves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granuleexocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions inclathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably byrecruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles.Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC)phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunitMYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response.Required for maintenance of normal renal structure and function by supporting normal podocyte function
 summary
for PIK3C2A: PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the
3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of
cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell
migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric
consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and
delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst
p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have
recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes
(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI
3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to
play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.
Gene Wiki entry for PIK3C2A
|
Genomic Views
for PIK3C2A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PIK3C2A gene promoter:
C/EBPbeta FOXF2 POU6F1 (c2) Evi-1 HNF-1A c-Rel HNF-1 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PIK3C2A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIK3C2A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.5-p14 Ensembl cytogenetic band: 11p15.1 HGNC cytogenetic band: 11p15.5-p14PIK3C2A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M017099: view genomic region
(about GC identifiers)
Start:
|
17,099,277 bp from pter |
End:
|
17,229,530 bp from pter |
Size:
|
130,254 bases |
Orientation:
|
minus strand |
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Proteins
for PIK3C2A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: P3C2A_HUMAN, O00443 (See
protein sequence)Recommended Name: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha Size: 1686 amino acids; 190680 Da
Cofactor: Calcium or magnesium. Manganese cannot be used
Subunit: Part of a complex with ERBB2 and EGFR. Interacts with clathrin trimers
Subcellular location: Cell membrane. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Cytoplasm.Note=According to PubMed:10766823 and PubMed:11239472, it is found in the cell membrane, the Golgi apparatus and inclathrin-coated vesicles. According to PubMed:17038310 it inserts preferentially into membranes containingPtdIns(4,5)P2. According to PubMed:11606566, it is nuclear and cytoplasmic. Associated with RNA-containing structures.According to PubMed:14563213, it is mainly cytoplasmic
4 PDB 3D structures from  and Proteopedia  for PIK3C2A:2AR5 (3D)
2IWL (3D)
2REA (3D)
2RED (3D)
Secondary accessions: B0LPH2 Q14CQ9Explore the universe of human proteins at neXtProt for PIK3C2A: NX_O00443
Post-translational modifications:
Phosphorylated upon insulin stimulation; which may lead to enzyme activation (By similarity). Phosphorylated on Ser-259during mitosis and upon UV irradiation; which does not change enzymatic activity but leads to proteasomal degradation.Ser-259 phosphorylation may be mediated by CDK1 or JNK, depending on the physiological state of the cell1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00443
4/11 DME Specific Peptides for PIK3C2A (O00443) (see all 11)
PIK3C2A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002636.2
ENSEMBL proteins: ENSP00000265970 ENSP00000436244 ENSP00000436969 ENSP00000438687 Reactome Protein details: O00443
Human Recombinant Protein Products for PIK3C2A:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
PIK3C2A for ontologies About GeneDecksing
PIK3C2A Antibody Products:
Assay Products for PIK3C2A: |
Protein
Domains /
Families
for PIK3C2A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PIK3C2A for domains About GeneDecksing
5/12 InterPro domains/families (see all 12):Graphical View of Domain Structure for InterPro Entry O00443ProtoNet protein and cluster: O00443 3 Blocks protein families: IPB000008 C2 domain IPB000341 Phosphoinositide 3-kinase IPB000403 Phosphatidylinositol 3- and 4-kinase
UniProtKB/Swiss-Prot: P3C2A_HUMAN, O00443Similarity: Belongs to the PI3/PI4-kinase familySimilarity: Contains 1 C2 domainSimilarity: Contains 1 C2 PI3K-type domainSimilarity: Contains 1 PI3K-RBD domainSimilarity: Contains 1 PI3K/PI4K domainSimilarity: Contains 1 PIK helical domainSimilarity: Contains 1 PX (phox homology) domain |
Function
for PIK3C2A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: P3C2A_HUMAN, O00443Function: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate(PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions ininsulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasmamembrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through twodifferent mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway thatinvolves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granuleexocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions inclathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably byrecruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles.Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC)phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunitMYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response.Required for maintenance of normal renal structure and function by supporting normal podocyte functionCatalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol3,4-bisphosphateEnzyme regulation: Activated by insulin (By similarity). Only slightly inhibited by wortmannin and LY294002. Activatedby clathrinBiophysicochemical properties: Kinetic parameters: KM=122 uM for PtdIns (in the absence of phosphatidylserine); KM=64uM for PtdIns (in the presence of phosphatidylserine); KM=25 uM for PtdIns4P (in the presence of phosphatidylserine);KM=15 uM for ATP (with PtdIns as substrate) (in the absence of phosphatidylserine); KM=32 uM for ATP (with PtdIns assubstrate) (in the presence of phosphatidylserine); KM=54 uM for ATP (with PtdIns4P as substrate) (in the presence ofphosphatidylserine); Vmax=990 pmol/min/mg enzyme with PtdIns as substrate (in the absence of phosphatidylserine);Vmax=200 pmol/min/mg enzyme with PtdIns as substrate (in the presence of phosphatidylserine); Vmax=240 pmol/min/mgenzyme with PtdIns4P as substrate (in the presence of phosphatidylserine); Vmax=6800 pmol/min/mg enzyme toward ATPwith PtdIns as substrate (in the absence of phosphatidylserine); Vmax=805 pmol/min/mg enzyme toward ATP with PtdIns assubstrate (in the presence of phosphatidylserine); Vmax=880 pmol/min/mg enzyme toward ATP with PtdIns4P as substrate(in the presence of phosphatidylserine); Note=In the absence of the carrier phosphatidylserine, enzymatic kineticstoward PtdIns4P are non-linear; Enzyme Numbers (IUBMB): EC 2.7.1.1541 2 EC 2.7.12
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
PIK3C2A for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for PIK3C2A:
7 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Pik3c2a):
PIK3C2A for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3C2A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3C2A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for PIK3C2A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3C2A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3C2A |
|
Pathways & Interactions
for PIK3C2A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/21 super-pathways (see all 21) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mTOR Pathway | | | 2 | Clathrin derived vesicle budding | | | 3 | PI Metabolism | | | 4 | Metabolism | | | 5 | Inositol phosphate metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PIK3C2A
5/9 Tocris Bioscience Pathways for PIK3C2A (see all 9)
5/6  BioSystems Pathways for PIK3C2A (see all 6)
5/12 
Reactome Pathways for PIK3C2A (see all 12)
4  PharmGKB Pathways for PIK3C2A
3 
Kegg Pathways (Kegg details for PIK3C2A):
PIK3C2A for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIK3C2A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/437 Interacting proteins for PIK3C2A (O004432, 3 ENSP000002659704) via UniProtKB, MINT, STRING, and/or I2D (see all 437)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table
PIK3C2A for ontologies About GeneDecksing
|
Drugs & Compounds
for PIK3C2A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PIK3C2A for compounds About GeneDecksing
Compounds for PIK3C2A available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| LY 294002 hydrochloride | Selective PI 3-kinase inhibitor | [154447-36-6] | | Quercetin | Non-selective PI 3-kinase inhibitor | [117-39-5] | | PI 103 hydrochloride | Inhibitor of PI 3-kinase, mTOR and DNA-PK | [371935-74-9] | | Wortmannin | Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 | [19545-26-7] | | PI 828 | PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130) | [942289-87-4] |
10/129 HMDB Compounds for PIK3C2A (see all 129) About this table
10/106 Novoseek chemical compound relationships for PIK3C2A gene (see all 106) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| creatinine |
86.4 |
489 |
17300133 (3), 9501676 (3), 10522418 (2), 15518777 (2) (see all 99) |
| dantrolene |
60.5 |
3 |
2354060 (1), 9017254 (1), 8610025 (1) |
| alpha-hydroxybutyrate |
58.7 |
2 |
14761575 (1), 16824338 (1) |
| fluvastatin |
54.1 |
4 |
15518777 (1), 9203045 (1), 14872552 (1), 16446645 (1) |
| lactate |
52.2 |
62 |
16778757 (2), 12890994 (2), 11367646 (1), 9766526 (1) (see all 55) |
| pravastatin |
49.7 |
6 |
8591712 (3), 1733092 (1), 17532682 (1), 19104420 (1) |
| simvastatin |
48.3 |
6 |
11583721 (1), 1904357 (1), 12240878 (1), 8482062 (1) (see all 6) |
| atorvastatin |
46.7 |
5 |
12534315 (1), 12972104 (1), 17535079 (1), 18356785 (1) |
| aspartate |
45.4 |
29 |
14759379 (2), 14761575 (1), 17206443 (1), 2402132 (1) (see all 28) |
| uric acid |
44.9 |
28 |
17338197 (4), 9429015 (2), 14759379 (2), 1784405 (1) (see all 15) |
Search CenterWatch for drugs/clinical trials and news about PIK3C2A / P3C2A
|
Transcripts
for PIK3C2A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PIK3C2A gene: NM_002645.2 Unigene Cluster for PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha Hs.175343 [show with all ESTs]Unigene Representative Sequence: NM_0026456 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000531428(uc009ygu.1) ENST00000265970(uc001mmq.4 uc010rcw.2 uc010rcx.1 uc009ygv.1)
ENST00000533645(uc001mmr.3) ENST00000532035 ENST00000503729 ENST00000540361
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3C2A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3C2A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PIK3C2A (NM_002645) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PIK3C2A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3C2A |
Additional cDNA sequence: AK294416.1 AK299474.1 AK304262.1 AK309610.1 AK310248.1 AL049998.1 AL832699.1 BC031681.1 BC040952.1 BC113658.1 BX648778.1 CR627335.1 Y13367.1 9 DOTS entries: DT.412738 DT.101973514 DT.437411 DT.101980888 DT.120715322 DT.91646588 DT.100784357 DT.100888938 DT.121502290 24/179 AceView cDNA sequences (see all 179): AW675279 AA689576 AA348462 CA393722 BU679326 AI954464 AI026632 AI264571 BX099044 AI476460 AI610239 CA867091 BQ723761 AV725484 AW471240 AA905750 AI811319 AA344473 CA437365 CA867024 AL706251 AV682436 BQ016976 H10335
GeneLoc Exon Structure
|
Expression
for PIK3C2A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PIK3C2A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTTTGACT
About this image
See PIK3C2A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PIK3C2A
SOURCE GeneReport for Unigene cluster: Hs.175343
UniProtKB/Swiss-Prot: P3C2A_HUMAN, O00443Tissue specificity: Expressed in columnar and transitional epithelia, mononuclear cells, smooth muscle cells, andendothelial cells lining capillaries and small venules (at protein level). Ubiquitously expressed, with highest levelsin heart, placenta and ovary, and lowest levels in the kidney. Detected at low levels in islets of Langerhans fromtype 2 diabetes mellitus individuals
SABiosciences Expression via Pathway-Focused PCR Arrays including PIK3C2A:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PIK3C2A
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3C2A |
Orthologs
for PIK3C2A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PIK3C2A gene from 6/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PIK3C2A1 |
phosphoinositide-3-kinase, class 2, alpha polypeptide |
75.63(n)
76.13(a) |
|
423070 XM_421003.2 XP_421003.2 |
lizard
(Anolis carolinensis) |
Reptilia |
PIK3C2A6 |
-- |
73(a) |
1 ↔ 1 |
1(66635711-66675310) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.145862 |
Xenopus laevis transcribed sequence with moderate similarity more |
74.81(n) |
|
CA794192.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BG728812.12 |
-- |
76.03(n) |
|
BG728812.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Pi3K68D1 , 3 |
phosphorylation phosphatidylinositol
3-kinase3
Phosphotidylinositol 3 kinase 68D1 |
36(a)3
47.68(n)1
39.4(a)1 |
|
393291 NM_168475.21 NP_729743.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
piki-11 |
Protein PIKI-1 |
43.02(n)
31.47(a) |
|
181618 NM_078128.2 NP_510529.1 |
ENSEMBL Gene Tree for PIK3C2A (if available)
TreeFam Gene Tree for PIK3C2A (if available) |
Paralogs
for PIK3C2A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PIK3C2A gene
- PIK3CD2 PIK3C2B2 PIK3CA2 PIK3C2G2 PIK3CG2 PIK3CB2 PIK3C32
12 SIMAP similar genes for PIK3C2A using alignment to 5 protein entries: P3C2A_HUMAN (see all proteins):DKFZp686G16234 PIK3C2B variant protein PIK3C2B DKFZp779K1237 CHR11SYT SYTL2
PIK3CG PIK3CB PIK3C2G PIK3CD SYT15 PI4KB
PIK3C2A for paralogs About GeneDecksing
|
Genomic Variants
for PIK3C2A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PIK3C2A (17099277 - 17229530 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PIK3C2A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PIK3C2A |
|
Disorders
/ Diseases
for PIK3C2A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PIK3C2A for disorders About GeneDecksing
OMIM gene information: 603601
OMIM disorders: --
20/180  diseases for PIK3C2A (see all 180): About MalaCardscreatine phosphokinase, elevated serum creatine phosphokinase pure red-cell aplasia disseminated intravascular coagulation
wandering spleen vibrio vulnificus infection spinal cord injury status asthmaticus
bronchiolitis obliterans organizing pneumonia chronic progressive external ophthalmoplegia muscular dystrophy nephropathia epidemica
pericardial effusion neuroleptic malignant syndrome silent myocardial infarction gas gangrene
sine scleroderma mixed connective tissue disease amyopathic dermatomyositis myocardial infarction
12 diseases from the University of Copenhagen DISEASES database for PIK3C2A:Myocardial infarction Myopathy Malignant hyperthermia Vascular disease
Neuropathy Kidney failure Gas gangrene Intermediate coronary syndrome
Hypothyroidism Pneumonia Dermatitis Trichinosis 10/98 Novoseek disease relationships for PIK3C2A gene (see all 98) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| creatine phosphokinase, elevated serum |
86.7 |
13 |
15925432 (1), 1803046 (1), 1398197 (1), 16553491 (1) (see all 12) |
| rhabdomyolysis |
86.6 |
51 |
17571610 (2), 10401940 (2), 17884958 (2), 9757925 (2) (see all 41) |
| polymyositis |
77.2 |
7 |
1464989 (1), 7536446 (1), 7564001 (1), 10614168 (1) (see all 7) |
| neuroleptic malignant syndrome |
74.8 |
4 |
20159196 (1), 1362345 (1), 17214072 (1), 10820583 (1) |
| dermatomyositis |
72.4 |
4 |
12355862 (1), 10614168 (1), 2244255 (1), 10496106 (1) |
| myositis |
71.2 |
15 |
10638867 (1), 18320790 (1), 1803046 (1), 10426928 (1) (see all 14) |
| myopathy |
70.2 |
30 |
15453946 (3), 2082493 (3), 9658790 (2), 18320790 (1) (see all 21) |
| acute myocardial infarction |
70.1 |
32 |
1842714 (2), 15815362 (2), 9778551 (1), 10522418 (1) (see all 24) |
| renal failure acute |
68 |
12 |
10365541 (1), 1848151 (1), 1477759 (1), 14717236 (1) (see all 11) |
| myocardial infarction |
63.8 |
28 |
17059151 (3), 9163005 (2), 19627702 (2), 10663915 (1) (see all 23) |
Human Genome Epidemiology (HuGE) Navigator: PIK3C2A (8 documents)
Export disorders for PIK3C2A gene to outside databases
|
Publications
for PIK3C2A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PIK3C2A gene, integrated from 9 sources (see all 675):
(articles sorted by number of sources associating them with PIK3C2A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of a human phosphoinositide 3-kinase with a C2 domain which displays reduced sensitivity to the inhibitor wortmannin. (PubMed id 9337861)1, 2, 3 Domin J.... Waterfield M.D. (1997)
- Individual phosphoinositide 3-kinase C2alpha domain activities independently regulate clathrin function. (PubMed id 16215232)1, 2, 9 Gaidarov I....Keen J.H. (2005)
- Structural and membrane binding analysis of the Phox homology domain of phosphoinositide 3-kinase-C2alpha. (PubMed id 17038310)1, 2, 9 Stahelin R.V.... Cho W. (2006)
- Phosphatidylinositol 3-kinase c2alpha contains a nuclear localization sequence and associates with nuclear speckles. (PubMed id 11606566)1, 2, 9 Didichenko S.A. and Thelen M. (2001)
- Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. (PubMed id 10805725)1, 2, 9 Arcaro A....Domin J. (2000)
- PI3KC2I+, a class II PI3K, is required for dynamin-ind ependent internalization pathways. (PubMed id 21081650)1, 2 Krag C....Salcini A.E. (2010)
- Role of class II phosphoinositide 3-kinase in cell si gnalling. (PubMed id 17371240)1, 2 Falasca M. and Maffucci T. (2007)
- Topographical expression of class IA and class II phosphoinositide 3- kinase enzymes in normal human tissues is consistent with a role in differentiation. (PubMed id 14563213)1, 2 El Sheikh S.S....Lalani E.-N. (2003)
- Mitotic and stress-induced phosphorylation of HsPI3K-C2alpha targets the protein for degradation. (PubMed id 12719431)1, 2 Didichenko S.A.... Thelen M. (2003)
- The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking. (PubMed id 11239472)1, 2 Gaidarov I.... Keen J.H. (2001)
|
External Searches for PIK3C2A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PIK3C2A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PIK3C2A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PIK3C2A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PIK3C2A gene:
Search GeneIP for patents involving PIK3C2A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PIK3C2A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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 | |
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| | |  | OriGene Antibodies for PIK3C2A | | OriGene shRNA RFP for PIK3C2A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PIK3C2A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PIK3C2A | | | OriGene Protein Over-expression Lysate for PIK3C2A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PIK3C2A | | OriGene 3'-UTR Clone for PIK3C2A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3C2A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3C2A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PIK3C2A | | OriGene Custom Protein Services for PIK3C2A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PIK3C2A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PIK3C2A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIK3C2A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIK3C2A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIK3C2A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIK3C2A |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3C2A |
|  |  |  |  | | | | ThermoFisher Antibodies for PIK3C2A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3C2A |
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