Aliases for PIK3C2A Gene
- Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 Alpha 2 3
- Phosphoinositide-3-Kinase, Class 2, Alpha Polypeptide 2 3
- Phosphoinositide 3-Kinase-C2-Alpha 3 4
- PtdIns-3-Kinase C2 Subunit Alpha 3 4
- PI3K-C2-Alpha 3 4
- EC 188.8.131.52 4 64
- Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit Alpha 3
- Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing Subunit Alpha 3
External Ids for PIK3C2A Gene
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]
GeneCards Summary for PIK3C2A Gene
PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 Alpha) is a Protein Coding gene. Diseases associated with PIK3C2A include wandering spleen and trichinosis. Among its related pathways are Regulation of actin cytoskeleton and VEGF Signaling Pathway. GO annotations related to this gene include phosphatidylinositol binding and 1-phosphatidylinositol-4-phosphate 3-kinase activity. An important paralog of this gene is PIK3CB.
UniProtKB/Swiss-Prot for PIK3C2A Gene
Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function.
PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the 3OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes (C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI 3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.