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Aliases for PIH1D3 Gene

Aliases for PIH1D3 Gene

  • PIH1 Domain Containing 3 2 3 5
  • Sarcoma Antigen NY-SAR-97 2 3 4
  • PIH1 Domain-Containing Protein 3 3 4
  • CXorf41 3 4
  • Chromosome X Open Reading Frame 41 2
  • NYSAR97 3

External Ids for PIH1D3 Gene

Previous HGNC Symbols for PIH1D3 Gene

  • CXorf41

Previous GeneCards Identifiers for PIH1D3 Gene

  • GC0XP106450

Summaries for PIH1D3 Gene

GeneCards Summary for PIH1D3 Gene

PIH1D3 (PIH1 Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include chaperone binding.

UniProtKB/Swiss-Prot for PIH1D3 Gene

  • Plays a role in cytoplasmic pre-assembly of axonemal dynein.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIH1D3 Gene

Genomics for PIH1D3 Gene

Regulatory Elements for PIH1D3 Gene

Promoters for PIH1D3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PIH1D3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PIH1D3 Gene

107,206,559 bp from pter
107,244,243 bp from pter
37,685 bases
Plus strand

Genomic View for PIH1D3 Gene

Genes around PIH1D3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIH1D3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIH1D3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIH1D3 Gene

Proteins for PIH1D3 Gene

  • Protein details for PIH1D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein PIH1D3
    Protein Accession:
    Secondary Accessions:
    • D3DUX5
    • Q86WE1

    Protein attributes for PIH1D3 Gene

    214 amino acids
    Molecular mass:
    24069 Da
    Quaternary structure:
    • Interacts with HSPA1A/B, HSP90AA1 and DNAI2.
    • Sequence=AAO65181.1; Type=Frameshift; Positions=162; Evidence={ECO:0000305};

neXtProt entry for PIH1D3 Gene

Proteomics data for PIH1D3 Gene at MOPED

Post-translational modifications for PIH1D3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIH1D3 Gene

No data available for DME Specific Peptides for PIH1D3 Gene

Domains & Families for PIH1D3 Gene

Protein Domains for PIH1D3 Gene


Suggested Antigen Peptide Sequences for PIH1D3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PIH1 family.
  • Belongs to the PIH1 family.
genes like me logo Genes that share domains with PIH1D3: view

No data available for Gene Families for PIH1D3 Gene

Function for PIH1D3 Gene

Molecular function for PIH1D3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cytoplasmic pre-assembly of axonemal dynein.

Phenotypes for PIH1D3 Gene

GenomeRNAi human phenotypes for PIH1D3:
genes like me logo Genes that share phenotypes with PIH1D3: view

Animal Model Products

CRISPR Products

miRNA for PIH1D3 Gene

miRTarBase miRNAs that target PIH1D3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIH1D3 Gene

Localization for PIH1D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIH1D3 Gene

Cytoplasm. Note=Localized to the cytoplasm of spermatogenic cells. {ECO:0000250 UniProtKB:Q3KNI6}.

Subcellular locations from

Jensen Localization Image for PIH1D3 Gene COMPARTMENTS Subcellular localization image for PIH1D3 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for PIH1D3 Gene

Pathways & Interactions for PIH1D3 Gene

SuperPathways for PIH1D3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PIH1D3 Gene


No data available for Pathways by source and SIGNOR curated interactions for PIH1D3 Gene

Drugs & Compounds for PIH1D3 Gene

No Compound Related Data Available

Transcripts for PIH1D3 Gene

mRNA/cDNA for PIH1D3 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PIH1D3 Gene

PIH1 domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIH1D3 Gene

No ASD Table

Relevant External Links for PIH1D3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PIH1D3 Gene

mRNA expression in normal human tissues for PIH1D3 Gene

mRNA differential expression in normal tissues according to GTEx for PIH1D3 Gene

This gene is overexpressed in Testis (x31.2).

SOURCE GeneReport for Unigene cluster for PIH1D3 Gene Hs.128836

mRNA Expression by UniProt/SwissProt for PIH1D3 Gene

Tissue specificity: Expressed in testis, small intestine, prostate, adrenal gland, spleen, lung, bladder, breast and ovary.
genes like me logo Genes that share expression patterns with PIH1D3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PIH1D3 Gene

Orthologs for PIH1D3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PIH1D3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PIH1D3 35
  • 76.91 (n)
  • 70.24 (a)
  • 70 (a)
(Canis familiaris)
Mammalia PIH1D3 35
  • 81.46 (n)
  • 73.83 (a)
PIH1D3 36
  • 72 (a)
(Mus musculus)
Mammalia Pih1d3 35
  • 73.97 (n)
  • 63.33 (a)
Pih1h3b 16
E230019M04Rik 36
  • 59 (a)
Pih1d3 36
  • 59 (a)
(Pan troglodytes)
Mammalia PIH1D3 35
  • 89.95 (n)
  • 85.65 (a)
PIH1D3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Pih1d3 35
  • 75.4 (n)
  • 64.76 (a)
(Monodelphis domestica)
Mammalia PIH1D3 36
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia PIH1D3 36
  • 55 (a)
(Gallus gallus)
Aves C4HXORF41 35
  • 61.99 (n)
  • 52.63 (a)
PIH1D3 36
  • 50 (a)
(Anolis carolinensis)
Reptilia PIH1D3 36
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pih1d3 35
  • 58.42 (n)
  • 47.89 (a)
(Danio rerio)
Actinopterygii pih1d3 35
  • 54.67 (n)
  • 47.09 (a)
pih1d3 36
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5048 35
  • 44.64 (n)
  • 36.78 (a)
CG5048 36
  • 29 (a)
Species with no ortholog for PIH1D3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PIH1D3 Gene

Gene Tree for PIH1D3 (if available)
Gene Tree for PIH1D3 (if available)

Paralogs for PIH1D3 Gene

No data available for Paralogs for PIH1D3 Gene

Variants for PIH1D3 Gene

Sequence variations from dbSNP and Humsavar for PIH1D3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747740163 -- 107,216,679(+) AATGG(C/T)TTATC reference, synonymous-codon
rs747782487 -- 107,208,918(+) ACTTT(-/C)AAAAA intron-variant
rs747828013 -- 107,229,780(+) CTTCC(C/G)GGGTT intron-variant
rs747848361 -- 107,243,980(+) TTAGG(A/C)TCTCA utr-variant-3-prime
rs747895998 -- 107,229,057(+) AACAC(G/T)GATTA intron-variant

Variation tolerance for PIH1D3 Gene

Residual Variation Intolerance Score: 39.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.22% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for PIH1D3 Gene

Disorders for PIH1D3 Gene

Relevant External Links for PIH1D3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PIH1D3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIH1D3 Gene

Publications for PIH1D3 Gene

  1. Immunomic analysis of human sarcoma. (PMID: 12601173) Lee S.-Y. … Scanlan M.J. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 67
  2. Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm. (PMID: 24421334) Dong F. … Hamada H. (J. Cell Biol. 2014) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for PIH1D3 Gene

Sources for PIH1D3 Gene