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Aliases for PIH1D3 Gene

Aliases for PIH1D3 Gene

  • PIH1 Domain Containing 3 2 3
  • Sarcoma Antigen NY-SAR-97 2 3 4
  • PIH1 Domain-Containing Protein 3 3 4
  • CXorf41 3 4
  • Chromosome X Open Reading Frame 41 2
  • Protein PIH1D3 3
  • NYSAR97 3

External Ids for PIH1D3 Gene

Previous HGNC Symbols for PIH1D3 Gene

  • CXorf41

Previous GeneCards Identifiers for PIH1D3 Gene

  • GC0XP106450

Summaries for PIH1D3 Gene

GeneCards Summary for PIH1D3 Gene

PIH1D3 (PIH1 Domain Containing 3) is a Protein Coding gene. Diseases associated with PIH1D3 include sarcoma.

UniProtKB/Swiss-Prot for PIH1D3 Gene

  • Plays a role in cytoplasmic pre-assembly of axonemal dynein.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIH1D3 Gene

Genomics for PIH1D3 Gene

Genomic Location for PIH1D3 Gene

Start:
107,206,632 bp from pter
End:
107,244,243 bp from pter
Size:
37,612 bases
Orientation:
Plus strand

Genomic View for PIH1D3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIH1D3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIH1D3 Gene

No data available for Regulatory Elements for PIH1D3 Gene

Proteins for PIH1D3 Gene

  • Protein details for PIH1D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQM4-PIHD3_HUMAN
    Recommended name:
    Protein PIH1D3
    Protein Accession:
    Q9NQM4
    Secondary Accessions:
    • D3DUX5
    • Q86WE1

    Protein attributes for PIH1D3 Gene

    Size:
    214 amino acids
    Molecular mass:
    24069 Da
    Quaternary structure:
    • Interacts with HSPA1A/B, HSP90AA1 and DNAI2.
    SequenceCaution:
    • Sequence=AAO65181.1; Type=Frameshift; Positions=162; Evidence={ECO:0000305};

neXtProt entry for PIH1D3 Gene

Proteomics data for PIH1D3 Gene at MOPED

Post-translational modifications for PIH1D3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIH1D3 Gene

No data available for DME Specific Peptides for PIH1D3 Gene

Domains for PIH1D3 Gene

Protein Domains for PIH1D3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NQM4

UniProtKB/Swiss-Prot:

PIHD3_HUMAN :
  • Q9NQM4
Family:
  • Belongs to the PIH1 family.
genes like me logo Genes that share domains with PIH1D3: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for PIH1D3 Gene

Function for PIH1D3 Gene

Molecular function for PIH1D3 Gene

UniProtKB/Swiss-Prot Function: Plays a role in cytoplasmic pre-assembly of axonemal dynein.

Gene Ontology (GO) - Molecular Function for PIH1D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0051087 chaperone binding ISS --
genes like me logo Genes that share ontologies with PIH1D3: view

miRNA for PIH1D3 Gene

miRTarBase miRNAs that target PIH1D3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PIH1D3 Gene

Localization for PIH1D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIH1D3 Gene

Cytoplasm. Note=Localized to the cytoplasm of spermatogenic cells. {ECO:0000250 UniProtKB:Q3KNI6}.

Gene Ontology (GO) - Cellular Components for PIH1D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with PIH1D3: view

No data available for Subcellular locations from COMPARTMENTS for PIH1D3 Gene

Pathways for PIH1D3 Gene

SuperPathways for PIH1D3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PIH1D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030317 sperm motility ISS --
GO:0070286 axonemal dynein complex assembly ISS --
genes like me logo Genes that share ontologies with PIH1D3: view

No data available for Pathways by source for PIH1D3 Gene

Transcripts for PIH1D3 Gene

mRNA/cDNA for PIH1D3 Gene

(16) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PIH1D3 Gene

PIH1 domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIH1D3 Gene

No ASD Table

Relevant External Links for PIH1D3 Gene

GeneLoc Exon Structure for
PIH1D3
ECgene alternative splicing isoforms for
PIH1D3

Expression for PIH1D3 Gene

mRNA expression in normal human tissues for PIH1D3 Gene

mRNA differential expression in normal tissues according to GTEx for PIH1D3 Gene

This gene is overexpressed in Testis (31.2).

SOURCE GeneReport for Unigene cluster for PIH1D3 Gene Hs.128836

mRNA Expression by UniProt/SwissProt for PIH1D3 Gene

Q9NQM4-PIHD3_HUMAN
Tissue specificity: Expressed in testis, small intestine, prostate, adrenal gland, spleen, lung, bladder, breast and ovary.
genes like me logo Genes that share expressions with PIH1D3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for PIH1D3 Gene

Orthologs for PIH1D3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PIH1D3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIH1D3 35
  • 89.95 (n)
  • 85.65 (a)
PIH1D3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CXHXORF41 36
  • 70 (a)
OneToOne
PIH1D3 35
  • 76.91 (n)
  • 70.24 (a)
dog
(Canis familiaris)
Mammalia PIH1D3 35
  • 81.46 (n)
  • 73.83 (a)
PIH1D3 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia E230019M04Rik 36
  • 59 (a)
OneToMany
Pih1d3 35
  • 73.97 (n)
  • 63.33 (a)
Pih1d3 16
Pih1d3 36
  • 59 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia PIH1D3 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIH1D3 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pih1d3 35
  • 75.4 (n)
  • 64.76 (a)
chicken
(Gallus gallus)
Aves C4HXORF41 35
  • 61.99 (n)
  • 52.63 (a)
PIH1D3 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIH1D3 36
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pih1d3 35
  • 58.42 (n)
  • 47.89 (a)
zebrafish
(Danio rerio)
Actinopterygii pih1d3 35
  • 54.67 (n)
  • 47.09 (a)
pih1d3 36
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5048 35
  • 44.64 (n)
  • 36.78 (a)
CG5048 36
  • 29 (a)
OneToOne
Species with no ortholog for PIH1D3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PIH1D3 Gene

ENSEMBL:
Gene Tree for PIH1D3 (if available)
TreeFam:
Gene Tree for PIH1D3 (if available)

Paralogs for PIH1D3 Gene

No data available for Paralogs for PIH1D3 Gene

Variants for PIH1D3 Gene

Sequence variations from dbSNP and Humsavar for PIH1D3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1055244 -- 107,243,254(+) AAATC(A/C)CTATG reference, missense
rs1294084 -- 107,209,457(+) GGAAT(G/T)GAGTT intron-variant
rs1294085 -- 107,225,478(+) TATCA(G/T)AAACA intron-variant
rs1885643 -- 107,242,014(+) TATAT(A/T)GTAAA intron-variant
rs1936015 -- 107,224,522(+) GGAGA(C/T)TGACA intron-variant

Relevant External Links for PIH1D3 Gene

HapMap Linkage Disequilibrium report
PIH1D3
Locus Specific Mutation Databases (LSDB)
PIH1D3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PIH1D3 Gene

Disorders for PIH1D3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PIH1D3 Gene including...

Search for PIH1D3 Gene in MalaCards »
genes like me logo Genes that share disorders with PIH1D3: view

No data available for UniProtKB/Swiss-Prot for PIH1D3 Gene

Publications for PIH1D3 Gene

  1. Immunomic analysis of human sarcoma. (PMID: 12601173) Lee S.-Y. … Scanlan M.J. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm. (PMID: 24421334) Dong F. … Hamada H. (J. Cell Biol. 2014) 2 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for PIH1D3 Gene

Sources for PIH1D3 Gene

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