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Aliases for PIH1D2 Gene

Aliases for PIH1D2 Gene

  • PIH1 Domain Containing 2 2 3

External Ids for PIH1D2 Gene

Summaries for PIH1D2 Gene

GeneCards Summary for PIH1D2 Gene

PIH1D2 (PIH1 Domain Containing 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIH1D2 Gene

Genomics for PIH1D2 Gene

Genomic Location for PIH1D2 Gene

Start:
112,064,010 bp from pter
End:
112,074,274 bp from pter
Size:
10,265 bases
Orientation:
Minus strand

Genomic View for PIH1D2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIH1D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIH1D2 Gene

Proteins for PIH1D2 Gene

  • Protein details for PIH1D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWB5-PIHD2_HUMAN
    Recommended name:
    PIH1 domain-containing protein 2
    Protein Accession:
    Q8WWB5
    Secondary Accessions:
    • B4DU48
    • E9PD82

    Protein attributes for PIH1D2 Gene

    Size:
    315 amino acids
    Molecular mass:
    35957 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PIH1D2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIH1D2 Gene

Proteomics data for PIH1D2 Gene at MOPED

Post-translational modifications for PIH1D2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for PIH1D2 Gene

Domains for PIH1D2 Gene

Protein Domains for PIH1D2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

PIHD2_HUMAN
Family:
  • Belongs to the PIH1 family.:
    • Q8WWB5
genes like me logo Genes that share domains with PIH1D2: view

No data available for Gene Families for PIH1D2 Gene

Function for PIH1D2 Gene

Gene Ontology (GO) - Molecular Function for PIH1D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0017160 Ral GTPase binding IPI 24056301
genes like me logo Genes that share ontologies with PIH1D2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PIH1D2 Gene

Localization for PIH1D2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIH1D2 Gene COMPARTMENTS Subcellular localization image for PIH1D2 gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for PIH1D2 Gene

Pathways for PIH1D2 Gene

SuperPathways for PIH1D2 Gene

No Data Available

Interacting Proteins for PIH1D2 Gene

Gene Ontology (GO) - Biological Process for PIH1D2 Gene

None

No data available for Pathways by source for PIH1D2 Gene

Transcripts for PIH1D2 Gene

Unigene Clusters for PIH1D2 Gene

PIH1 domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIH1D2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1:
SP2: -
SP3:
SP4: -

Relevant External Links for PIH1D2 Gene

GeneLoc Exon Structure for
PIH1D2
ECgene alternative splicing isoforms for
PIH1D2

Expression for PIH1D2 Gene

mRNA expression in normal human tissues for PIH1D2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIH1D2 Gene

This gene is overexpressed in Testis (18.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PIH1D2 Gene

SOURCE GeneReport for Unigene cluster for PIH1D2 Gene Hs.420662

genes like me logo Genes that share expressions with PIH1D2: view

Orthologs for PIH1D2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PIH1D2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIH1D2 36
  • 99.79 (n)
  • 99.68 (a)
PIH1D2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PIH1D2 36
  • 87.3 (n)
  • 83.17 (a)
PIH1D2 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIH1D2 36
  • 87.22 (n)
  • 83.71 (a)
PIH1D2 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pih1d2 36
  • 77.46 (n)
  • 72.38 (a)
Pih1d2 16
Pih1d2 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIH1D2 37
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIH1D2 37
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pih1d2 36
  • 77.88 (n)
  • 72.06 (a)
chicken
(Gallus gallus)
Aves PIH1D2 37
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIH1D2 37
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734438 36
  • 55.23 (n)
  • 48.04 (a)
zebrafish
(Danio rerio)
Actinopterygii pih1d2 36
  • 51.25 (n)
  • 41.04 (a)
pih1d2 37
  • 39 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
OneToOne
Species with no ortholog for PIH1D2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PIH1D2 Gene

ENSEMBL:
Gene Tree for PIH1D2 (if available)
TreeFam:
Gene Tree for PIH1D2 (if available)

Paralogs for PIH1D2 Gene

No data available for Paralogs for PIH1D2 Gene

Variants for PIH1D2 Gene

Sequence variations from dbSNP and Humsavar for PIH1D2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs471526 -- 112,068,330(+) AACTA(C/T)CACAG intron-variant
rs518795 -- 112,067,324(-) AAAAA(C/T)TATTG intron-variant, downstream-variant-500B
rs551945 -- 112,065,996(-) ttttt(G/T)gacag intron-variant
rs677699 -- 112,070,430(+) ATTCA(A/G)CTTAC intron-variant
rs1298174 -- 112,067,657(-) gagac(G/T)gagtt intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PIH1D2 Gene

Variant ID Type Subtype PubMed ID
esv2745077 CNV Deletion 23290073

Relevant External Links for PIH1D2 Gene

HapMap Linkage Disequilibrium report
PIH1D2

Disorders for PIH1D2 Gene

No disorders were found for PIH1D2 Gene.

No data available for UniProtKB/Swiss-Prot for PIH1D2 Gene

Publications for PIH1D2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response. (PMID: 24056301) Simicek M. … Sablina A.A. (Nat. Cell Biol. 2013) 3
  5. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3

Products for PIH1D2 Gene

Sources for PIH1D2 Gene

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