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Aliases for PIGZ Gene

Aliases for PIGZ Gene

  • Phosphatidylinositol Glycan Anchor Biosynthesis, Class Z 2 3
  • SMP3 3 4 6
  • Phosphatidylinositol-Glycan Biosynthesis Class Z Protein 3 4
  • Dol-P-Man Dependent GPI Mannosyltransferase 2 3
  • Phosphatidylinositol Glycan, Class Z 2 3
  • GPI Mannosyltransferase IV 3 4
  • GPI Mannosyltransferase 4 2 3
  • GPI-MT-IV 3 4
  • PIG-Z 3 4
  • SMP3 Mannosyltransferase 3
  • SMP3 Homolog 4
  • EC 2.4.1.- 4
  • EC 2.4.1 63
  • HSMP3 4

External Ids for PIGZ Gene

Previous GeneCards Identifiers for PIGZ Gene

  • GC03M198162
  • GC03M196673
  • GC03M193973

Summaries for PIGZ Gene

Entrez Gene Summary for PIGZ Gene

  • The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. This gene encodes a protein that is localized to the endoplasmic reticulum, and is involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching fourth mannose to GPI precursors during the assembly of GPI anchors. [provided by RefSeq, Jul 2008]

GeneCards Summary for PIGZ Gene

PIGZ (Phosphatidylinositol Glycan Anchor Biosynthesis, Class Z) is a Protein Coding gene. Among its related pathways are Post-translational modification- synthesis of GPI-anchored proteins. GO annotations related to this gene include mannosyltransferase activity and alpha-1,2-mannosyltransferase activity.

UniProtKB/Swiss-Prot for PIGZ Gene

  • Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIGZ Gene

Genomics for PIGZ Gene

Regulatory Elements for PIGZ Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PIGZ Gene

196,946,343 bp from pter
196,969,060 bp from pter
22,718 bases
Minus strand

Genomic View for PIGZ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIGZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIGZ Gene

Proteins for PIGZ Gene

  • Protein details for PIGZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GPI mannosyltransferase 4
    Protein Accession:
    Secondary Accessions:
    • Q9H9G6

    Protein attributes for PIGZ Gene

    579 amino acids
    Molecular mass:
    63471 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PIGZ Gene

Proteomics data for PIGZ Gene at MOPED

Selected DME Specific Peptides for PIGZ Gene

Post-translational modifications for PIGZ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIGZ Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for PIGZ Gene

Gene Families for PIGZ Gene

  • DOLPM :Dolichyl D-mannosyl phosphate dependent mannosyltransferases
  • PIG :Phosphatidylinositol glycan anchor biosynthesis

Protein Domains for PIGZ Gene

Suggested Antigen Peptide Sequences for PIGZ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q86VD9
  • Belongs to the glycosyltransferase 22 family. PIGZ subfamily.
genes like me logo Genes that share domains with PIGZ: view

Function for PIGZ Gene

Molecular function for PIGZ Gene

UniProtKB/Swiss-Prot Function: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues.

Enzyme Numbers (IUBMB) for PIGZ Gene

Gene Ontology (GO) - Molecular Function for PIGZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000026 alpha-1,2-mannosyltransferase activity IMP 15208306
GO:0000030 mannosyltransferase activity IGI 15208306
GO:0016757 transferase activity, transferring glycosyl groups --
genes like me logo Genes that share ontologies with PIGZ: view

Phenotypes for PIGZ Gene

GenomeRNAi human phenotypes for PIGZ:
genes like me logo Genes that share phenotypes with PIGZ: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PIGZ Gene

Localization for PIGZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIGZ Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for PIGZ Gene COMPARTMENTS Subcellular localization image for PIGZ gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PIGZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 15208306
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PIGZ: view

Pathways for PIGZ Gene

genes like me logo Genes that share pathways with PIGZ: view

Pathways by source for PIGZ Gene

UniProtKB/Swiss-Prot Q86VD9-PIGZ_HUMAN

  • Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis

Interacting Proteins for PIGZ Gene

Gene Ontology (GO) - Biological Process for PIGZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006506 GPI anchor biosynthetic process IMP 15208306
GO:0008152 metabolic process --
GO:0097502 mannosylation IMP 15208306
genes like me logo Genes that share ontologies with PIGZ: view

Compounds for PIGZ Gene

(898) HMDB Compounds for PIGZ Gene

Compound Synonyms Cas Number PubMed IDs
  • 1-Hydroxy-2-amino-3-oxo-octadecane
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • Sulfatide (d18:1/12:0)
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • Sulfatide (d18:1/14:0)
Not Available
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • Sulfatide (d18:1/16:0)
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • Sulfatide (d18:1/18:0)
genes like me logo Genes that share compounds with PIGZ: view

Transcripts for PIGZ Gene

Unigene Clusters for PIGZ Gene

Phosphatidylinositol glycan anchor biosynthesis, class Z:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIGZ

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PIGZ

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIGZ Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4
SP1: - -
SP2: -

Relevant External Links for PIGZ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PIGZ Gene

mRNA expression in normal human tissues for PIGZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIGZ Gene

This gene is overexpressed in Colon - Transverse (8.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PIGZ Gene

SOURCE GeneReport for Unigene cluster for PIGZ Gene Hs.518403

mRNA Expression by UniProt/SwissProt for PIGZ Gene

Tissue specificity: Widely expressed at low level, with highest level in brain and colon.
genes like me logo Genes that share expressions with PIGZ: view

In Situ Assay Products

Orthologs for PIGZ Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIGZ Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PIGZ 35
  • 97.8 (n)
  • 96.79 (a)
(Bos Taurus)
Mammalia LOC525407 35
  • 83.36 (n)
  • 78.24 (a)
  • 76 (a)
(Canis familiaris)
Mammalia PIGZ 35
  • 83.39 (n)
  • 79.24 (a)
  • 81 (a)
(Mus musculus)
Mammalia Pigz 35
  • 81.38 (n)
  • 79.85 (a)
Pigz 16
Pigz 36
  • 78 (a)
(Monodelphis domestica)
Mammalia PIGZ 36
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia PIGZ 36
  • 60 (a)
(Gallus gallus)
Aves PIGZ 35
  • 56.49 (n)
  • 52.25 (a)
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pigz 35
  • 51.3 (n)
  • 47.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3419 36
  • 20 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMP3 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for PIGZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PIGZ Gene

Gene Tree for PIGZ (if available)
Gene Tree for PIGZ (if available)

Paralogs for PIGZ Gene

No data available for Paralogs for PIGZ Gene

Variants for PIGZ Gene

Sequence variations from dbSNP and Humsavar for PIGZ Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs168047 -- 196,961,656(-) AGAAG(A/C)GGCAA intron-variant
rs168048 -- 196,945,983(+) ttttt(C/T)cccca downstream-variant-500B
rs173037 -- 196,967,623(+) AGAGT(C/G)CATTT intron-variant
rs335819 -- 196,964,720(+) TTATG(A/G)GAAGT intron-variant
rs335820 -- 196,967,317(+) GTGAA(C/T)GAGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIGZ Gene

Variant ID Type Subtype PubMed ID
esv2726594 CNV Deletion 23290073
nsv822421 CNV Loss 20364138
nsv878191 CNV Loss 21882294
esv29616 CNV Loss 19812545

Relevant External Links for PIGZ Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIGZ Gene

Disorders for PIGZ Gene

(1) University of Copenhagen DISEASES for PIGZ Gene

genes like me logo Genes that share disorders with PIGZ: view

No data available for UniProtKB/Swiss-Prot for PIGZ Gene

Publications for PIGZ Gene

  1. Human Smp3p adds a fourth mannose to yeast and human glycosylphosphatidylinositol precursors in vivo. (PMID: 15208306) Taron B.W. … Taron C.H. (J. Biol. Chem. 2004) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The essential Smp3 protein is required for addition of the side-branching fourth mannose during assembly of yeast glycosylphosphatidylinositols. (PMID: 11356840) Grimme S.J. … Orlean P. (J. Biol. Chem. 2001) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Deficiencies in the essential Smp3 mannosyltransferase block glycosylphosphatidylinositol assembly and lead to defects in growth and cell wall biogenesis in Candida albicans. (PMID: 15470093) Grimme S.J. … Orlean P. (Microbiology (Reading, Engl.) 2004) 23

Products for PIGZ Gene

Sources for PIGZ Gene

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