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PIGZ Gene

protein-coding   GIFtS: 54
GCID: GC03M196673

Phosphatidylinositol Glycan Anchor Biosynthesis, Class Z

(Previous names: phosphatidylinositol glycan, class Z)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Phosphatidylinositol Glycan Anchor Biosynthesis, Class Z1 2     PIG-Z2 3
SMP32 3 5     GPI Mannosyltransferase IV2 3
Phosphatidylinositol Glycan, Class Z1 2     SMP3 Mannosyltransferase2
Dol-P-Man Dependent GPI Mannosyltransferase1 2     EC 2.4.1.-3
GPI Mannosyltransferase 41 2     hSMP33
Phosphatidylinositol-Glycan Biosynthesis Class Z Protein2 3     SMP3 Homolog3
GPI-MT-IV2 3     EC 2.4.18

External Ids:    HGNC: 305961   Entrez Gene: 802352   Ensembl: ENSG000001192277   OMIM: 6116715   UniProtKB: Q86VD93   
ORGUL members:         

Export aliases for PIGZ gene to outside databases

Previous GC identifers: GC03M198162 GC03M193973


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PIGZ Gene:
The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor
proteins to the cell surface. This gene encodes a protein that is localized to the endoplasmic reticulum, and is
involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of
dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching
fourth mannose to GPI precursors during the assembly of GPI anchors. (provided by RefSeq, Jul 2008)

GeneCards Summary for PIGZ Gene:
PIGZ (phosphatidylinositol glycan anchor biosynthesis, class Z) is a protein-coding gene. GO annotations related to this gene include mannosyltransferase activity and alpha-1,2-mannosyltransferase activity.

UniProtKB/Swiss-Prot: PIGZ_HUMAN, Q86VD9
Function: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth
mannose to some trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is
facultative and only scarcely detected, suggesting that it only exists in some tissues




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PIGZ gene promoter:
         GR   Elk-1   AML1a   GR-beta   Brachyury   Bach2   HNF-4alpha2   HNF-4alpha1   ZIC2/Zic2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIGZ promoter sequence
   Search Chromatin IP Primers for PIGZ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIGZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

PIGZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIGZ gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M196673:  view genomic region     (about GC identifiers)

Start:
196,673,214 bp from pter      End:
196,695,931 bp from pter
Size:
22,718 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PIGZ_HUMAN, Q86VD9 (See protein sequence)
Recommended Name: GPI mannosyltransferase 4  
Size: 579 amino acids; 63471 Da
Caution: It is uncertain whether Met-1 or Met-32 is the initiator
Secondary accessions: Q9H9G6

Explore the universe of human proteins at neXtProt for PIGZ: NX_Q86VD9

Explore proteomics data for PIGZ at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for PIGZ (Q86VD9)
     PDEFFQS  HQEARFL 


    See PIGZ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079439.2  
    ENSEMBL proteins: 
     ENSP00000413405   ENSP00000405341   ENSP00000389327  

    PIGZ Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for PIGZ
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    Novus Biologicals PIGZ Protein
    Novus Biologicals PIGZ Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PIGZ

     
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    antibodies-online proteins for PIGZ (2 products) 

     
    antibodies-online peptides for PIGZ

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    Cloud-Clone Corp. ELISAs for PIGZ
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    antibodies-online kits for PIGZ (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DOLPM: Dolichyl D-mannosyl phosphate dependent mannosyltransferases
    PIG: Phosphatidylinositol glycan anchor biosynthesis

    1 InterPro protein domain:
     IPR005599 GPI_mannosylTrfase

    Graphical View of Domain Structure for InterPro Entry Q86VD9

    ProtoNet protein and cluster: Q86VD9

    1 Blocks protein domain: IPB005599 Plasmid Maintenance Protein

    UniProtKB/Swiss-Prot: PIGZ_HUMAN, Q86VD9
    Similarity: Belongs to the glycosyltransferase 22 family. PIGZ subfamily


    Find genes that share domains with PIGZ           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIGZ_HUMAN, Q86VD9
    Function: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth
    mannose to some trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is
    facultative and only scarcely detected, suggesting that it only exists in some tissues

         Enzyme Numbers (IUBMB): EC 2.4.12 EC 2.4.1.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000026alpha-1,2-mannosyltransferase activity IMP15208306
    GO:0000030mannosyltransferase activity IGI15208306
    GO:0016757transferase activity, transferring glycosyl groups ----
         
    Find genes that share ontologies with PIGZ           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PIGZ:
     Increased G1 DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PIGZ

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PIGZ (see all 11):
    hsa-miR-34c-5p hsa-miR-449b hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-449a hsa-miR-34a hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidPIGZ 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat PIGZ

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    GenScript: all cDNA clones in your preferred vector: PIGZ (NM_025163)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIGZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIGZ

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PIGZ_HUMAN, Q86VD9: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA15208306
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with PIGZ           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PIGZ About    
    See pathways by source

    SuperPathContained pathways About
    1Post-translational modification- synthesis of GPI-anchored proteins
    Glycosylphosphatidylinositol(GPI)-anchor biosynthesis0.76


    Find genes that share SuperPaths with PIGZ           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for PIGZ):
        Glycosylphosphatidylinositol(GPI)-anchor biosynthesis

    UniProtKB/Swiss-Prot: PIGZ_HUMAN, Q86VD9
    Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PIGZ
    Interactions:

        Search GeneGlobe Interaction Network for PIGZ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for PIGZ (Q86VD93 ENSP000004134054) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    LPIN3Q9BQK83, ENSP000003623544I2D: score=1 STRING: ENSP00000362354
    CHMP6Q96FZ73I2D: score=5 
    BYSLQ138953I2D: score=1 
    H2AFZP0C0S53I2D: score=1 
    YME1L1Q96TA23I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006506GPI anchor biosynthetic process IMP15208306
    GO:0097502mannosylation IMP15208306

    Find genes that share ontologies with PIGZ           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PIGZ

    Selected HMDB Compounds for PIGZ (see all 898)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
    3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
    3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
    3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
    3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
    3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
    3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PIGZ gene: 
    NM_025163.3  

    Unigene Cluster for PIGZ:

    Phosphatidylinositol glycan anchor biosynthesis, class Z
    Hs.518403  [show with all ESTs]
    Unigene Representative Sequence: NM_025163
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000412723(uc003fxh.3) ENST00000413127 ENST00000443835 ENST00000238138

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PIGZ (see all 11):
    hsa-miR-34c-5p hsa-miR-449b hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-449a hsa-miR-34a hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidPIGZ 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat PIGZ

    Additional mRNA sequence: 

    AK022830.1 AK296867.1 BC018804.1 BC044640.1 

    3 DOTS entries:

    DT.75129227  DT.40270544  DT.40278190 

    Selected AceView cDNA sequences (see all 38):

    BM504443 CR601084 CA313131 BM504224 BQ025743 NM_025163 BE348708 CD632503 
    R19260 BC044640 BX493581 BG767520 AU150122 BX431209 AK022830 BG760692 
    BX281271 BG760211 BG763689 BG763440 BC018804 AL537470 BM833053 BU754440 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PIGZ    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4
    SP1:                          -     -         
    SP2:                          -               
    SP3:                                          


    ECgene alternative splicing isoforms for PIGZ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PIGZ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACTCTGAT
    PIGZ Expression
    About this image


    PIGZ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
    PIGZ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIGZ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.518403

    UniProtKB/Swiss-Prot: PIGZ_HUMAN, Q86VD9
    Tissue specificity: Widely expressed at low level, with highest level in brain and colon

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGZ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PIGZ gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pigz1 , 5 phosphatidylinositol glycan anchor biosynthesis, class more1, 5 81.38(n)1
    79.85(a)1
      16 (22.40 cM)5
    2398271  NM_172822.31  NP_766410.21 
     319338515 
    chicken
    (Gallus gallus)
    Aves PIGZ1 phosphatidylinositol glycan anchor biosynthesis, class more 56.49(n)
    52.25(a)
      429144  XM_426699.3  XP_426699.2 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pigz1 phosphatidylinositol glycan anchor biosynthesis, class more 51.3(n)
    47.58(a)
      100497115  XM_002937841.2  XP_002937887.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG34196
    --
    20(a)
    1 ↔ 1
    2R(20299414-20302820)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMP36
    Alpha 1,2-mannosyltransferase involved in glycosyl...
    28(a)
    1 ↔ 1
    XV(609838-611388) YOR149C


    ENSEMBL Gene Tree for PIGZ (if available)
    TreeFam Gene Tree for PIGZ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PIGZ (see all 646)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1403701231,2
    --196672760(+) CCCTCC/TGGGGC 1 -- ds50010--------
    rs751280951,2
    C--196672814(+) ACCTGG/CCTCCC 1 -- ds50013Minor allele frequency- C:0.15NA EA 242
    rs2009922101,2
    C--196672836(+) AATGA-/CCCCCT 1 -- ds50010--------
    rs3358251,2
    C,F,H--196672840(+) ACCCCT/Cttttt 1 -- ds500115Minor allele frequency- C:0.48EA NS NA WA 1756
    rs1143241241,2
    C--196672841(+) CCCCCC/TTTTTT 1 -- ds50010--------
    rs1680481,2
    C--196672854(+) tttttC/Tcccca 1 -- ds50016Minor allele frequency- T:0.41NA WA EA 364
    rs1821864581,2
    --196672873(+) TCTTGC/TTCTGT 1 -- ds50010--------
    rs49165881,2
    C--196672905(+) GCTCTC/TGGTTC 1 -- ds50013Minor allele frequency- T:0.15NA EA 242
    rs1160162871,2
    F--196673086(+) TACCTT/CGGCCT 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1455852611,2
    C--196673310(+) TGAAGA/TACAAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PIGZ (196673214 - 196695931 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PIGZ:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726594CNV Deletion23290073
    esv29616CNV Loss19812545
    nsv878191CNV Loss21882294
    nsv822421CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611671    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for PIGZ:
    Intracranial aneurysm

    Find genes that share disorders with PIGZ           About GenesLikeMe


    Export disorders for PIGZ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIGZ gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with PIGZ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Smp3p adds a fourth mannose to yeast and human glycosylphosphatidylinositol precursors in vivo. (PubMed id 15208306)1, 2, 3 Taron B.W.... Taron C.H. (J. Biol. Chem. 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The essential Smp3 protein is required for addition of the side-branching fourth mannose during assembly of yeast glycosylphosphatidylinositols. (PubMed id 11356840)1, 9 Grimme S.J....Orlean P. (J. Biol. Chem. 2001)
    5. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteins. (PubMed id 12655644)1 Eisenhaber B....Eisenhaber F. (Bioessays 2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Common origin and evolution of glycosyltransferases using Dol-P- monosaccharides as donor substrate. (PubMed id 12200473)1 Oriol R.... Codogno P. (Mol. Biol. Evol. 2002)
    10. Deficiencies in the essential Smp3 mannosyltransferase block glycosylphosphatidylinositol assembly and lead to defects in growth and cell wall biogenesis in Candida albicans. (PubMed id 15470093)9 Grimme S.J....Orlean P. (Microbiology (Reading, Engl.) 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80235 HGNC: 30596 AceView: SMP3 Ensembl:ENSG00000119227 euGenes: HUgn80235
    ECgene: PIGZ Kegg: 80235 H-InvDB: PIGZ

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PIGZ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PIGZ gene:
    Search GeneIP for patents involving PIGZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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