Aliases for PIGZ Gene
External Ids for PIGZ Gene
Previous GeneCards Identifiers for PIGZ Gene
The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. This gene encodes a protein that is localized to the endoplasmic reticulum, and is involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching fourth mannose to GPI precursors during the assembly of GPI anchors. [provided by RefSeq, Jul 2008]
GeneCards Summary for PIGZ Gene
PIGZ (Phosphatidylinositol Glycan Anchor Biosynthesis, Class Z) is a Protein Coding gene. Among its related pathways are Post-translational modification- synthesis of GPI-anchored proteins. GO annotations related to this gene include mannosyltransferase activity and alpha-1,2-mannosyltransferase activity.
UniProtKB/Swiss-Prot for PIGZ Gene
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues.