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Aliases for PIGY Gene

Aliases for PIGY Gene

  • Phosphatidylinositol Glycan Anchor Biosynthesis, Class Y 2 3
  • Phosphatidylinositol-Glycan Biosynthesis Class Y Protein 3 4
  • PIG-Y 3 4
  • Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit Y 3
  • Phosphatidylinositol Glycan, Class Y 2

External Ids for PIGY Gene

Previous GeneCards Identifiers for PIGY Gene

  • GC04M089800
  • GC04M089661
  • GC04M089442
  • GC04M085194

Summaries for PIGY Gene

Entrez Gene Summary for PIGY Gene

  • The protein encoded by this gene is part of the GPI-N-acetylglucosaminyltransferase (GIP-GnT) complex which initiates the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is synthesized in the endoplasmic reticulum and serves as an anchor for many surface proteins. Proteins containing GPI anchors can have an important role in cell-cell interactions. The transcript for this gene is bicistronic. The downstream open reading frame encodes this GPI-GnT complex protein, while the upstream open reading frame encodes a protein with unknown function, as represented by GeneID:100996939. [provided by RefSeq, Aug 2012]

GeneCards Summary for PIGY Gene

PIGY (Phosphatidylinositol Glycan Anchor Biosynthesis, Class Y) is a Protein Coding gene. Diseases associated with PIGY include sarcocystosis and pthirus pubis infestation. Among its related pathways are Metabolism and Post-translational modification- synthesis of GPI-anchored proteins.

UniProtKB/Swiss-Prot for PIGY Gene

  • Component of the GPI-GlcNAc transferase (GPI-GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI-anchors for cell surface proteins. May act by regulating the catalytic subunit PIGA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIGY Gene

Genomics for PIGY Gene

Regulatory Elements for PIGY Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PIGY Gene

Start:
88,520,978 bp from pter
End:
88,523,801 bp from pter
Size:
2,824 bases
Orientation:
Minus strand

Genomic View for PIGY Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIGY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIGY Gene

Proteins for PIGY Gene

  • Protein details for PIGY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3MUY2-PIGY_HUMAN
    Recommended name:
    Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y
    Protein Accession:
    Q3MUY2
    Secondary Accessions:

    Protein attributes for PIGY Gene

    Size:
    71 amino acids
    Molecular mass:
    8058 Da
    Quaternary structure:
    • Interacts with the GPI-GnT complex composed of PIGA, PIGC, PIGH, PIGP, PIGQ and DPM2. Interacts directly with PIGA. Does not interact with Ras proteins.
    Miscellaneous:
    • PREY and PIGY, 2 apparently unrelated proteins, are respectively the product of an upstream and a downstream ORF contained in a single bicistronic transcript

neXtProt entry for PIGY Gene

Proteomics data for PIGY Gene at MOPED

Post-translational modifications for PIGY Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIGY Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PIGY Gene

Domains for PIGY Gene

Gene Families for PIGY Gene

HGNC:
  • PIG :Phosphatidylinositol glycan anchor biosynthesis

Protein Domains for PIGY Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PIGY Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PIGY: view

No data available for UniProtKB/Swiss-Prot for PIGY Gene

Function for PIGY Gene

Molecular function for PIGY Gene

UniProtKB/Swiss-Prot Function: Component of the GPI-GlcNAc transferase (GPI-GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI-anchors for cell surface proteins. May act by regulating the catalytic subunit PIGA.

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIGY

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PIGY Gene

Localization for PIGY Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIGY Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIGY Gene COMPARTMENTS Subcellular localization image for PIGY gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
mitochondrion 3
nucleus 2

Gene Ontology (GO) - Cellular Components for PIGY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IDA 16162815
GO:0005789 endoplasmic reticulum membrane IDA 16162815
GO:0005886 plasma membrane IDA 16162815
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PIGY: view

Pathways for PIGY Gene

genes like me logo Genes that share pathways with PIGY: view

Pathways by source for PIGY Gene

UniProtKB/Swiss-Prot Q3MUY2-PIGY_HUMAN

  • Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis

Interacting Proteins for PIGY Gene

Gene Ontology (GO) - Biological Process for PIGY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006506 GPI anchor biosynthetic process IEA --
genes like me logo Genes that share ontologies with PIGY: view

Compounds for PIGY Gene

(898) HMDB Compounds for PIGY Gene

Compound Synonyms Cas Number PubMed IDs
3-Dehydrosphinganine
  • 1-Hydroxy-2-amino-3-oxo-octadecane
16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • Sulfatide (d18:1/12:0)
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • Sulfatide (d18:1/14:0)
Not Available
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • Sulfatide (d18:1/16:0)
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • Sulfatide (d18:1/18:0)
244215-65-4
genes like me logo Genes that share compounds with PIGY: view

Transcripts for PIGY Gene

mRNA/cDNA for PIGY Gene

(389) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PIGY Gene

Phosphatidylinositol glycan anchor biosynthesis, class Y:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIGY

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIGY Gene

No ASD Table

Relevant External Links for PIGY Gene

GeneLoc Exon Structure for
PIGY
ECgene alternative splicing isoforms for
PIGY

Expression for PIGY Gene

mRNA expression in normal human tissues for PIGY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for PIGY Gene Hs.26136

genes like me logo Genes that share expressions with PIGY: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for PIGY Gene

Orthologs for PIGY Gene

This gene was present in the common ancestor of chordates.

Orthologs for PIGY Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIGY 35
  • 100 (n)
  • 100 (a)
PIGY 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PIGY 35
  • 91.08 (n)
  • 94.37 (a)
dog
(Canis familiaris)
Mammalia PIGY 35
  • 92.49 (n)
  • 97.18 (a)
mouse
(Mus musculus)
Mammalia Pigyl 35
  • 77 (n)
  • 84.51 (a)
Pigyl 36
  • 85 (a)
OneToOne
Pyurf 16
rat
(Rattus norvegicus)
Mammalia LOC100365921 35
  • 78.4 (n)
  • 88.73 (a)
chicken
(Gallus gallus)
Aves PIGY 35
  • 76.47 (n)
  • 91.18 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pigy 35
  • 74.65 (n)
  • 88.73 (a)
Str.20118 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13853 35
zebrafish
(Danio rerio)
Actinopterygii Dr.15340 35
Species with no ortholog for PIGY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PIGY Gene

ENSEMBL:
Gene Tree for PIGY (if available)
TreeFam:
Gene Tree for PIGY (if available)

Paralogs for PIGY Gene

Pseudogenes.org Pseudogenes for PIGY Gene

genes like me logo Genes that share paralogs with PIGY: view

No data available for Paralogs for PIGY Gene

Variants for PIGY Gene

Relevant External Links for PIGY Gene

HapMap Linkage Disequilibrium report
PIGY

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for PIGY Gene

Disorders for PIGY Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for PIGY Gene including...

Search for PIGY Gene in MalaCards »

(2) University of Copenhagen DISEASES for PIGY Gene

Relevant External Links for PIGY

Genetic Association Database (GAD)
PIGY
Human Genome Epidemiology (HuGE) Navigator
PIGY
genes like me logo Genes that share disorders with PIGY: view

No data available for UniProtKB/Swiss-Prot for PIGY Gene

Publications for PIGY Gene

  1. The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component. (PMID: 16162815) Murakami Y. … Kinoshita T. (Mol. Biol. Cell 2005) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for PIGY Gene

Sources for PIGY Gene

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