Aliases for PIGY Gene
External Ids for PIGY Gene
Previous GeneCards Identifiers for PIGY Gene
The protein encoded by this gene is part of the GPI-N-acetylglucosaminyltransferase (GIP-GnT) complex which initiates the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is synthesized in the endoplasmic reticulum and serves as an anchor for many surface proteins. Proteins containing GPI anchors can have an important role in cell-cell interactions. The transcript for this gene is bicistronic. The downstream open reading frame encodes this GPI-GnT complex protein, while the upstream open reading frame encodes a protein with unknown function, as represented by GeneID:100996939. [provided by RefSeq, Aug 2012]
GeneCards Summary for PIGY Gene
PIGY (Phosphatidylinositol Glycan Anchor Biosynthesis, Class Y) is a Protein Coding gene. Diseases associated with PIGY include sarcocystosis and pthirus pubis infestation. Among its related pathways are Metabolism and Post-translational modification- synthesis of GPI-anchored proteins.
UniProtKB/Swiss-Prot for PIGY Gene
Component of the GPI-GlcNAc transferase (GPI-GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI-anchors for cell surface proteins. May act by regulating the catalytic subunit PIGA.