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PIGX Gene

protein-coding   GIFtS: 53
GCID: GC03P196372

Phosphatidylinositol Glycan Anchor Biosynthesis, Class X

(Previous names: phosphatidylinositol glycan, class X)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phosphatidylinositol Glycan Anchor Biosynthesis, Class X1 2
PIG-X2 3
Phosphatidylinositol Glycan, Class X1
GPI-Mannosyltransferase Subunit2
Phosphatidylinositol-Glycan Biosynthesis Class X Protein2

External Ids:    HGNC: 260461   Entrez Gene: 549652   Ensembl: ENSG000001639647   OMIM: 6102765   UniProtKB: Q8TBF53   

Export aliases for PIGX gene to outside databases

Previous GC identifers: GC03P197928 GC03P196367 GC03P193735 GC03P196369


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PIGX Gene:
This gene encodes a type I transmembrane protein in the endoplasmic reticulum (ER). The protein is an essential
component of glycosylphosphatidylinositol-mannosyltransferase I, which transfers the first of the four mannoses
in the GPI-anchor precursors during GPI-anchor biosynthesis. Studies in rat indicate that the protein is
translated from a non-AUG translation initiation site. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Oct 2009)

GeneCards Summary for PIGX Gene:
PIGX (phosphatidylinositol glycan anchor biosynthesis, class X) is a protein-coding gene.

UniProtKB/Swiss-Prot: PIGX_HUMAN, Q8TBF5
Function: Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of
the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the
mannosyltransferase PIGM (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the PIGX gene promoter:
         Max1   TBP   USF1   AML1a   Olf-1   AP-4   MZF-1   SRY   USF-1   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for PIGX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIGX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

PIGX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIGX gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P196372:  view genomic region     (about GC identifiers)

Start:
196,366,646 bp from pter      End:
196,462,878 bp from pter
Size:
96,233 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PIGX_HUMAN, Q8TBF5 (See protein sequence)
Recommended Name: Phosphatidylinositol-glycan biosynthesis class X protein precursor  
Size: 258 amino acids; 28788 Da
Subunit: Interacts with PIGM (By similarity)
Sequence caution: Sequence=AAH22542.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH22542.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by
a non-canonical CTG leucine codon; Sequence=BAA91233.1; Type=Erroneous initiation; Note=Translation N-terminally
extended; Sequence=BAA91233.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A
sequence; Sequence=BAA91233.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine
is coded by a non-canonical CTG leucine codon;
Secondary accessions: Q9NWZ2
Alternative splicing: 2 isoforms:  Q8TBF5-1   Q8TBF5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PIGX: NX_Q8TBF5

Explore proteomics data for PIGX at MOPED

Post-translational modifications: 

  • N-glycosylated (By similarity)1
  • Ubiquitination2 at Lys82
  • Glycosylation2 at Thr31, Asn103
  • Modification sites at PhosphoSitePlus

  • See PIGX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001159776.1  NP_060331.3  

    ENSEMBL proteins: 
     ENSP00000409073   ENSP00000376192   ENSP00000296333   ENSP00000394722   ENSP00000393424  
     ENSP00000416446   ENSP00000413672   ENSP00000390804   ENSP00000317301   ENSP00000443269  
    Reactome Protein details: Q8TBF5

    PIGX Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PIGX

     
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    antibodies-online proteins for PIGX (2 products) 

     
    antibodies-online peptides for PIGX

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    antibodies-online antibodies for PIGX (18 products) 

    PIGX Assay Products:

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    Cloud-Clone Corp. CLIAs for PIGX
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    antibodies-online kits for PIGX (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PIG: Phosphatidylinositol glycan anchor biosynthesis

    1 InterPro protein domain:
     IPR013233 PIG-X/PBN1

    Graphical View of Domain Structure for InterPro Entry Q8TBF5

    ProtoNet protein and cluster: Q8TBF5

    UniProtKB/Swiss-Prot: PIGX_HUMAN, Q8TBF5
    Similarity: Belongs to the PIGX family


    Find genes that share domains with PIGX           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIGX_HUMAN, Q8TBF5
    Function: Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of
    the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the
    mannosyltransferase PIGM (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for PIGX:

     Increased G1 DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PIGX

    miRNA
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    miRTarBase miRNAs that target PIGX:
    hsa-mir-21-5p (MIRT031052), hsa-mir-192-5p (MIRT026837), hsa-mir-215-5p (MIRT024277)

    Block miRNA regulation of human, mouse, rat PIGX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PIGX (see all 27):
    hsa-miR-30c hsa-miR-548j hsa-miR-548i hsa-miR-513c hsa-miR-30d hsa-miR-3159 hsa-miR-30a hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidPIGX 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PIGX_HUMAN, Q8TBF5: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol2
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with PIGX           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PIGX About    
    See pathways by source

    SuperPathContained pathways About
    1Post-translational modification- synthesis of GPI-anchored proteins
    Post-translational modification- synthesis of GPI-anchored proteins0.76
    Synthesis of glycosylphosphatidylinositol (GPI)0.00
    Glycosylphosphatidylinositol(GPI)-anchor biosynthesis0.76
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30
    3Metabolism
    Metabolic pathways0.38


    Find genes that share SuperPaths with PIGX           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for PIGX
        Synthesis of glycosylphosphatidylinositol (GPI)


    2 Kegg Pathways  (Kegg details for PIGX):
        Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: PIGX_HUMAN, Q8TBF5
    Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PIGX
    Interactions:

        Search GeneGlobe Interaction Network for PIGX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for PIGX (Q8TBF53 ENSP000003173014) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIGMQ9H3S53, ENSP000003570694I2D: score=1 STRING: ENSP00000357069
    PIGBENSP000001643054STRING: ENSP00000164305
    PIGNENSP000003502634STRING: ENSP00000350263
    PIGVENSP000000785274STRING: ENSP00000078527
    PIGWENSP000003323134STRING: ENSP00000332313
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006501C-terminal protein lipidation TAS--
    GO:0006506GPI anchor biosynthetic process ----
    GO:0016254preassembly of GPI anchor in ER membrane TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with PIGX           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for PIGX

    Selected HMDB Compounds for PIGX (see all 898)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
    3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
    3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
    3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
    3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
    3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
    3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PIGX gene (2 alternative transcripts): 
    NM_001166304.1  NM_017861.3  

    Unigene Cluster for PIGX:

    Phosphatidylinositol glycan anchor biosynthesis, class X
    Hs.223296  [show with all ESTs]
    Unigene Representative Sequence: NM_001166304
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000426755 ENST00000392391(uc010iaj.3 uc003fwx.4 uc011btx.2)
    ENST00000296333 ENST00000457284 ENST00000453218 ENST00000421265 ENST00000415832
    ENST00000451319 ENST00000495440 ENST00000314118 ENST00000541663
    miRNA
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    hsa-miR-30c hsa-miR-548j hsa-miR-548i hsa-miR-513c hsa-miR-30d hsa-miR-3159 hsa-miR-30a hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidPIGX 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat PIGX
      QuantiFast Probe-based Assays in human, mouse, rat PIGX

    Additional mRNA sequence: 

    AK000529.1 AK294340.1 BC022542.1 

    8 DOTS entries:

    DT.100751729  DT.80100187  DT.95371554  DT.70104774  DT.95371556  DT.95371558  DT.40131731  DT.100778209 

    Selected AceView cDNA sequences (see all 122):

    CR619710 BQ130655 BM694954 BG105919 BU731672 BE673281 BP432100 BU159626 
    AW193851 BU732488 AA448292 AL133913 BI760115 AW299992 AA132190 BM709023 
    AI810352 BM564927 BE326876 AK000529 BM694867 BM457326 BQ029982 BQ002356 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PIGX (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b
    SP1:                    -     -           -     -           -                       -                           
    SP2:                    -     -           -     -           -                       -     -                     
    SP3:                    -     -           -                 -                                                   
    SP4:                    -     -           -     -                                                               
    SP5:                                                        -                       -     -                     


    ECgene alternative splicing isoforms for PIGX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PIGX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PIGX Expression
    About this image


    PIGX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Thyroid (Endocrine System)
    PIGX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIGX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.223296
        Custom PCR Arrays for PIGX
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PIGX gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pigx1 , 5 phosphatidylinositol glycan anchor biosynthesis, class more1, 5 83.62(n)1
    81.47(a)1
      16 (22.40 cM)5
    720841  NM_001111025.11  NP_001104495.11 
     320844205 
    chicken
    (Gallus gallus)
    Aves PIGX1 phosphatidylinositol glycan anchor biosynthesis, class more 54.61(n)
    44.72(a)
      424859  XM_422670.4  XP_422670.2 
    lizard
    (Anolis carolinensis)
    Reptilia PIGX6
    phosphatidylinositol glycan anchor biosynthesis, c...
    44(a)
    1 ↔ 1
    3(30802412-30816411)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pigx1 phosphatidylinositol glycan anchor biosynthesis, class more 52.69(n)
    40.61(a)
      448438  NM_001004985.1  NP_001004985.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pigx1 phosphatidylinositol glycan anchor biosynthesis, class more 48.48(n)
    35.89(a)
      570443  NM_001126436.1  NP_001119908.1 


    ENSEMBL Gene Tree for PIGX (if available)
    TreeFam Gene Tree for PIGX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PIGX (see all 511)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1502860381,2
    C--196441127(+) GCCAAG/TAGTTC 2 -- int10--------
    rs111854531,2
    C,F--196441140(+) GACCAG/CCCTGG 2 -- int16Minor allele frequency- C:0.49NA CSA WA EA 363
    rs111854541,2
    C,F--196441170(+) TCTCTA/GCAAAA 2 -- int16Minor allele frequency- G:0.48NA WA EA 364
    rs1378949401,2
    --196441191(+) GTAGCC/TAGGTG 2 -- int10--------
    rs1151115931,2
    C,F--196441306(+) TTCCAG/ACTTGT 2 -- int11Minor allele frequency- A:0.09WA 118
    rs357282801,2
    C--196441335(+) GTCTC-/T/TT  
            
    TTTTT
    2 -- int11NA 2
    rs754480401,2
    C--196441350(+) TTTTTA/TTTTGA 2 -- int11Minor allele frequency- T:0.00CSA 1
    rs1124321051,2
    F--196441399(+) GCAATG/CTCGGC 2 -- int11Minor allele frequency- C:0.50CSA 2
    rs1842596411,2
    --196441489(+) CACGAC/TGCCCG 2 -- int10--------
    rs1473198461,2
    --196441521(+) AAAGAC/TGGGGT 2 -- int10--------

    HapMap Linkage Disequilibrium report for PIGX (196366646 - 196462878 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PIGX:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829828CNV Loss17160897
    nsv524832CNV Loss19592680
    nsv878190CNV Loss21882294
    nsv878189CNV Loss21882294
    dgv5375n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PIGX
    DNA2.0 Custom Variant and Variant Library Synthesis for PIGX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610276    OMIM disorders: --


    Find genes that share disorders with PIGX           About GenesLikeMe


    Export disorders for PIGX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIGX gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with PIGX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I. (PubMed id 15635094)1, 2, 3 Ashida H.... Kinoshita T. (Mol. Biol. Cell 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    8. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    9. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54965 HGNC: 26046 AceView: FLJ20522andUNQ3030 Ensembl:ENSG00000163964 euGenes: HUgn54965
    ECgene: PIGX Kegg: 54965 H-InvDB: PIGX

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PIGX Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PIGX gene:
    Search GeneIP for patents involving PIGX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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