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Aliases for PIGX Gene

Aliases for PIGX Gene

  • Phosphatidylinositol Glycan Anchor Biosynthesis Class X 2 3 5
  • PIG-X 3 4
  • Phosphatidylinositol-Glycan Biosynthesis Class X Protein 3
  • Phosphatidylinositol Glycan, Class X 2
  • GPI-Mannosyltransferase Subunit 3

External Ids for PIGX Gene

Previous GeneCards Identifiers for PIGX Gene

  • GC03P197928
  • GC03P196367
  • GC03P193735
  • GC03P196369
  • GC03P196372

Summaries for PIGX Gene

Entrez Gene Summary for PIGX Gene

  • This gene encodes a type I transmembrane protein in the endoplasmic reticulum (ER). The protein is an essential component of glycosylphosphatidylinositol-mannosyltransferase I, which transfers the first of the four mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Studies in rat indicate that the protein is translated from a non-AUG translation initiation site. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for PIGX Gene

PIGX (Phosphatidylinositol Glycan Anchor Biosynthesis Class X) is a Protein Coding gene. Among its related pathways are Glycosylphosphatidylinositol (GPI)-anchor biosynthesis and Post-translational modification- synthesis of GPI-anchored proteins.

UniProtKB/Swiss-Prot for PIGX Gene

  • Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIGX Gene

Genomics for PIGX Gene

Regulatory Elements for PIGX Gene

Enhancers for PIGX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G196687 1.2 Ensembl ENCODE dbSUPER 11.8 +48.7 48726 1.4 CEBPB MAX CEBPG GABPA ZFHX2 ATF3 GATA2 EGR1 FOS ETV6 CEP19 PIGX LINC01063 RNU6-42P MELTF-AS1 GC03M196709
GH03G196726 0.6 ENCODE 22.7 +87.3 87301 1.0 NR2F1 JUN INSM2 FEZF1 JUND GATA2 FOS ZNF600 NR2F6 PRDM1 PIGX CEP19 TM4SF19 RNU6-910P PAK2
GH03G196689 1.3 Ensembl ENCODE dbSUPER 9.4 +52.8 52826 6.0 CTCF HNRNPUL1 KLF1 ZSCAN4 CEBPG CDC5L RAD21 ZFHX2 ZNF316 ZNF366 LINC01063 NCBP2 MELTF-AS1 RNF168 LOC220729 PIGX RNU6-910P TM4SF19 CEP19 GC03M196709
GH03G196790 1.3 Ensembl ENCODE 6.5 +152.8 152813 5.1 HDGF ATF1 FOXA2 PKNOX1 ARNT SIN3A ARID4B BRCA1 ZNF2 ZBTB7B CEP19 SENP5 NCBP2-AS1 NCBP2 MELTF-AS1 PIGX PAK2 SDHAP1 TCTEX1D2 RNU6-42P
GH03G196684 1.4 Ensembl ENCODE dbSUPER 5.8 +45.6 45628 1.7 HDGF PKNOX1 ATF1 WRNIP1 ZNF143 ZNF207 DEK JUNB REST TBX21 CEP19 PIGX PIGZ GC03M196709
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PIGX on UCSC Golden Path with GeneCards custom track

Promoters for PIGX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000164453 26 1601 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YBX1 ZNF2 ZNF766 CBX5

Genomic Location for PIGX Gene

Chromosome:
3
Start:
196,639,775 bp from pter
End:
196,736,007 bp from pter
Size:
96,233 bases
Orientation:
Plus strand

Genomic View for PIGX Gene

Genes around PIGX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIGX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIGX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIGX Gene

Proteins for PIGX Gene

  • Protein details for PIGX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBF5-PIGX_HUMAN
    Recommended name:
    Phosphatidylinositol-glycan biosynthesis class X protein
    Protein Accession:
    Q8TBF5
    Secondary Accessions:
    • Q9NWZ2

    Protein attributes for PIGX Gene

    Size:
    258 amino acids
    Molecular mass:
    28788 Da
    Quaternary structure:
    • Interacts with PIGM.
    SequenceCaution:
    • Sequence=AAH22542.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH22542.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=BAA91233.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91233.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91233.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305};

    Alternative splice isoforms for PIGX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIGX Gene

Post-translational modifications for PIGX Gene

No data available for DME Specific Peptides for PIGX Gene

Domains & Families for PIGX Gene

Gene Families for PIGX Gene

Protein Domains for PIGX Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8TBF5

UniProtKB/Swiss-Prot:

PIGX_HUMAN :
  • Belongs to the PIGX family.
Family:
  • Belongs to the PIGX family.
genes like me logo Genes that share domains with PIGX: view

Function for PIGX Gene

Molecular function for PIGX Gene

UniProtKB/Swiss-Prot Function:
Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM (By similarity).
genes like me logo Genes that share phenotypes with PIGX: view

Animal Model Products

CRISPR Products

miRNA for PIGX Gene

miRTarBase miRNAs that target PIGX

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PIGX

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIGX Gene

Localization for PIGX Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIGX Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIGX gene
Compartment Confidence
endoplasmic reticulum 4
cytosol 3
plasma membrane 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PIGX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PIGX: view

Pathways & Interactions for PIGX Gene

genes like me logo Genes that share pathways with PIGX: view

UniProtKB/Swiss-Prot Q8TBF5-PIGX_HUMAN

  • Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.

Gene Ontology (GO) - Biological Process for PIGX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006506 GPI anchor biosynthetic process IEA --
GO:0016254 preassembly of GPI anchor in ER membrane TAS --
genes like me logo Genes that share ontologies with PIGX: view

No data available for SIGNOR curated interactions for PIGX Gene

Drugs & Compounds for PIGX Gene

(3) Drugs for PIGX Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
sphingosine 1-phosphate Pharma Full agonist, Agonist 0

(841) Additional Compounds for PIGX Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Dehydrosphinganine
  • (2S)-2-amino-1-hydroxyoctadecan-3-one
  • 1-Hydroxy-2-amino-3-oxo-octadecane
  • 2-Amino-1-hydroxy-3-Octadecanone
  • 3-Dehydro-D-sphinganine
  • 3-Dehydrosphinganine
16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
244215-65-4
genes like me logo Genes that share compounds with PIGX: view

Transcripts for PIGX Gene

Unigene Clusters for PIGX Gene

Phosphatidylinositol glycan anchor biosynthesis, class X:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PIGX

Alternative Splicing Database (ASD) splice patterns (SP) for PIGX Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: - - - - -
SP8: -
SP9: - -

Relevant External Links for PIGX Gene

GeneLoc Exon Structure for
PIGX
ECgene alternative splicing isoforms for
PIGX

Expression for PIGX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PIGX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PIGX Gene

This gene is overexpressed in Heart (21.9), Pancreas (20.6), Retina (9.2), and Ovary (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PIGX Gene



Protein tissue co-expression partners for PIGX Gene

NURSA nuclear receptor signaling pathways regulating expression of PIGX Gene:

PIGX

SOURCE GeneReport for Unigene cluster for PIGX Gene:

Hs.223296

Evidence on tissue expression from TISSUES for PIGX Gene

  • Nervous system(4.4)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with PIGX: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIGX Gene

Orthologs for PIGX Gene

This gene was present in the common ancestor of chordates.

Orthologs for PIGX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIGX 34 35
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia PIGX 34 35
  • 86.3 (n)
cow
(Bos Taurus)
Mammalia PIGX 34 35
  • 85.06 (n)
mouse
(Mus musculus)
Mammalia Pigx 34 16 35
  • 83.62 (n)
rat
(Rattus norvegicus)
Mammalia Pigx 34
  • 80.95 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PIGX 35
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIGX 35
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIGX 34 35
  • 54.61 (n)
lizard
(Anolis carolinensis)
Reptilia PIGX 35
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pigx 34
  • 52.69 (n)
zebrafish
(Danio rerio)
Actinopterygii pigx 34 35
  • 48.48 (n)
Species where no ortholog for PIGX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PIGX Gene

ENSEMBL:
Gene Tree for PIGX (if available)
TreeFam:
Gene Tree for PIGX (if available)

Paralogs for PIGX Gene

No data available for Paralogs for PIGX Gene

Variants for PIGX Gene

Sequence variations from dbSNP and Humsavar for PIGX Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000058493 -- 196,720,368(+) GGGTA(C/T)GTGAG intron-variant
rs1000201572 -- 196,720,179(+) TTTGT(A/G)CAACT intron-variant
rs1000208651 -- 196,722,948(+) GCCAG(A/G)TATCT intron-variant
rs1000373958 -- 196,711,475(+) TGCCT(A/G)CCACC intron-variant, upstream-variant-2KB
rs1000381929 -- 196,717,124(+) TGAAA(C/T)GCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIGX Gene

Variant ID Type Subtype PubMed ID
esv2763775 CNV gain+loss 21179565
nsv1001045 CNV gain 25217958
nsv1003135 CNV gain 25217958
nsv1009975 CNV gain 25217958
nsv1014526 CNV gain 25217958
nsv1014692 CNV gain 25217958
nsv1114473 CNV deletion 24896259
nsv1131757 CNV deletion 24896259
nsv524832 CNV loss 19592680
nsv829828 CNV loss 17160897

Variation tolerance for PIGX Gene

Residual Variation Intolerance Score: 81.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.60; 56.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIGX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIGX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIGX Gene

Disorders for PIGX Gene

Relevant External Links for PIGX

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIGX

No disorders were found for PIGX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIGX Gene

Publications for PIGX Gene

  1. Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I. (PMID: 15635094) Ashida H. … Kinoshita T. (Mol. Biol. Cell 2005) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A systems-wide screen identifies substrates of the SCFI^TrCP ubiquitin ligase. (PMID: 25515538) Low T.Y. … Heck A.J. (Sci Signal 2014) 3 64
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64

Products for PIGX Gene

Sources for PIGX Gene

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