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Aliases for PIGX Gene

Aliases for PIGX Gene

  • Phosphatidylinositol Glycan Anchor Biosynthesis, Class X 2 3
  • PIG-X 3 4
  • Phosphatidylinositol-Glycan Biosynthesis Class X Protein 3
  • Phosphatidylinositol Glycan, Class X 2
  • GPI-Mannosyltransferase Subunit 3

External Ids for PIGX Gene

Summaries for PIGX Gene

Entrez Gene Summary for PIGX Gene

  • This gene encodes a type I transmembrane protein in the endoplasmic reticulum (ER). The protein is an essential component of glycosylphosphatidylinositol-mannosyltransferase I, which transfers the first of the four mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Studies in rat indicate that the protein is translated from a non-AUG translation initiation site. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for PIGX Gene

PIGX (Phosphatidylinositol Glycan Anchor Biosynthesis, Class X) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

UniProtKB/Swiss-Prot for PIGX Gene

  • Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIGX Gene

Genomics for PIGX Gene

Genomic Location for PIGX Gene

Start:
196,639,775 bp from pter
End:
196,736,007 bp from pter
Size:
96,233 bases
Orientation:
Plus strand

Genomic View for PIGX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIGX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIGX Gene

Regulatory Elements for PIGX Gene

Proteins for PIGX Gene

  • Protein details for PIGX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBF5-PIGX_HUMAN
    Recommended name:
    Phosphatidylinositol-glycan biosynthesis class X protein
    Protein Accession:
    Q8TBF5
    Secondary Accessions:
    • Q9NWZ2

    Protein attributes for PIGX Gene

    Size:
    258 amino acids
    Molecular mass:
    28788 Da
    Quaternary structure:
    • Interacts with PIGM.
    SequenceCaution:
    • Sequence=AAH22542.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH22542.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=BAA91233.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91233.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91233.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305};

    Alternative splice isoforms for PIGX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIGX Gene

Proteomics data for PIGX Gene at MOPED

Post-translational modifications for PIGX Gene

Other Protein References for PIGX Gene

No data available for DME Specific Peptides for PIGX Gene

Domains for PIGX Gene

Gene Families for PIGX Gene

HGNC:
  • PIG :Phosphatidylinositol glycan anchor biosynthesis

Protein Domains for PIGX Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

PIGX_HUMAN
Family:
  • Belongs to the PIGX family.:
    • Q8TBF5
genes like me logo Genes that share domains with PIGX: view

Function for PIGX Gene

Molecular function for PIGX Gene

UniProtKB/Swiss-Prot Function: Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM (By similarity).

Phenotypes for PIGX Gene

GenomeRNAi human phenotypes for PIGX:
genes like me logo Genes that share phenotypes with PIGX: view

miRNA for PIGX Gene

miRTarBase miRNAs that target PIGX

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for PIGX Gene

Localization for PIGX Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIGX Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIGX Gene COMPARTMENTS Subcellular localization image for PIGX gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PIGX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PIGX: view

Pathways for PIGX Gene

genes like me logo Genes that share pathways with PIGX: view

UniProtKB/Swiss-Prot Q8TBF5-PIGX_HUMAN

  • Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis

Gene Ontology (GO) - Biological Process for PIGX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0006506 GPI anchor biosynthetic process --
GO:0016254 preassembly of GPI anchor in ER membrane TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with PIGX: view

Compounds for PIGX Gene

(898) HMDB Compounds for PIGX Gene

Compound Synonyms Cas Number PubMed IDs
3-Dehydrosphinganine
  • 1-Hydroxy-2-amino-3-oxo-octadecane
16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • Sulfatide (d18:1/12:0)
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • Sulfatide (d18:1/14:0)
Not Available
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • Sulfatide (d18:1/16:0)
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • Sulfatide (d18:1/18:0)
244215-65-4
genes like me logo Genes that share compounds with PIGX: view

Transcripts for PIGX Gene

Unigene Clusters for PIGX Gene

Phosphatidylinositol glycan anchor biosynthesis, class X:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIGX Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: - - - - -
SP8: -
SP9: - -

Relevant External Links for PIGX Gene

GeneLoc Exon Structure for
PIGX
ECgene alternative splicing isoforms for
PIGX

Expression for PIGX Gene

mRNA expression in normal human tissues for PIGX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIGX Gene

SOURCE GeneReport for Unigene cluster for PIGX Gene Hs.223296

genes like me logo Genes that share expressions with PIGX: view

Orthologs for PIGX Gene

This gene was present in the common ancestor of chordates.

Orthologs for PIGX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIGX 36
  • 99.72 (n)
  • 99.57 (a)
PIGX 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PIGX 36
  • 85.06 (n)
  • 79.67 (a)
PIGX 37
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIGX 36
  • 86.3 (n)
  • 82.61 (a)
PIGX 37
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pigx 36
  • 83.62 (n)
  • 81.47 (a)
Pigx 16
Pigx 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIGX 37
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIGX 37
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pigx 36
  • 80.95 (n)
  • 78.99 (a)
chicken
(Gallus gallus)
Aves PIGX 36
  • 54.61 (n)
  • 44.72 (a)
PIGX 37
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIGX 37
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pigx 36
  • 52.69 (n)
  • 40.61 (a)
zebrafish
(Danio rerio)
Actinopterygii pigx 36
  • 48.48 (n)
  • 35.89 (a)
pigx 37
  • 32 (a)
OneToOne
Species with no ortholog for PIGX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PIGX Gene

ENSEMBL:
Gene Tree for PIGX (if available)
TreeFam:
Gene Tree for PIGX (if available)

Paralogs for PIGX Gene

No data available for Paralogs for PIGX Gene

Variants for PIGX Gene

Sequence variations from dbSNP and Humsavar for PIGX Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1047113 -- 196,734,603(-) GATTT(G/T)CATCC utr-variant-3-prime
rs1047120 -- 196,734,310(-) acagg(C/T)gtgag utr-variant-3-prime
rs1211970 -- 196,729,078(-) ttttt(A/T)gtaga intron-variant
rs1463626 -- 196,727,689(-) GGGTA(C/T)CAAAT intron-variant
rs1463627 -- 196,727,182(-) ATACG(C/T)GACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIGX Gene

Variant ID Type Subtype PubMed ID
dgv5375n71 CNV Gain 21882294
nsv829828 CNV Loss 17160897
nsv878189 CNV Loss 21882294
nsv878190 CNV Loss 21882294
nsv524832 CNV Loss 19592680

Relevant External Links for PIGX Gene

HapMap Linkage Disequilibrium report
PIGX

Disorders for PIGX Gene

No disorders were found for PIGX Gene.

No data available for UniProtKB/Swiss-Prot for PIGX Gene

Publications for PIGX Gene

  1. Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I. (PMID: 15635094) Ashida H. … Kinoshita T. (Mol. Biol. Cell 2005) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for PIGX Gene

Sources for PIGX Gene

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