Aliases for PIGW Gene
External Ids for PIGW Gene
Previous GeneCards Identifiers for PIGW Gene
Glycosylphosphatidylinositol (GPI) is a complex glycolipid that anchors many proteins to the cell surface. PIGW acts in the third step of GPI biosynthesis and acylates the inositol ring of phosphatidylinositol (Murakami et al., 2003 [PubMed 14517336]).[supplied by OMIM, Mar 2008]
GeneCards Summary for PIGW Gene
PIGW (Phosphatidylinositol Glycan Anchor Biosynthesis, Class W) is a Protein Coding gene. Diseases associated with PIGW include hyperphosphatasia-intellectual disability syndrome and hyperphosphatasia with mental retardation syndrome 5. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. GO annotations related to this gene include transferase activity, transferring acyl groups.
UniProtKB/Swiss-Prot for PIGW Gene
Required for the transport of GPI-anchored proteins to the plasma membrane (PubMed:24367057). Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins (By similarity).