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Aliases for PIGU Gene

Aliases for PIGU Gene

  • Phosphatidylinositol Glycan Anchor Biosynthesis, Class U 2 3
  • CDC91 (Cell Division Cycle 91, S. Cerevisiae, Homolog)-Like 1 2 3
  • Cell Division Cycle Protein 91-Like 1 3 4
  • GPI Transamidase Component PIG-U 3 4
  • GPI Transamidase Subunit 2 3
  • Protein CDC91-Like 1 3 4
  • CDC91L1 3 4
  • CDC91 Cell Division Cycle 91-Like 1 (S. Cerevisiae) 2
  • Cell Division Cycle 91-Like 1 Protein 3
  • GAB1 3

External Ids for PIGU Gene

Previous HGNC Symbols for PIGU Gene

  • CDC91L1

Previous GeneCards Identifiers for PIGU Gene

  • GC20M032613
  • GC20M033148
  • GC20M029928

Summaries for PIGU Gene

Entrez Gene Summary for PIGU Gene

  • The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for PIGU Gene

PIGU (Phosphatidylinositol Glycan Anchor Biosynthesis, Class U) is a Protein Coding gene. Among its related pathways are PI3K/AKT Signaling in Cancer and Immune System. GO annotations related to this gene include GPI anchor binding and GPI-anchor transamidase activity.

UniProtKB/Swiss-Prot for PIGU Gene

  • Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.

Gene Wiki entry for PIGU Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIGU Gene

Genomics for PIGU Gene

Regulatory Elements for PIGU Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PIGU Gene

Chromosome:
20
Start:
34,560,542 bp from pter
End:
34,698,790 bp from pter
Size:
138,249 bases
Orientation:
Minus strand

Genomic View for PIGU Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIGU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIGU Gene

Proteins for PIGU Gene

  • Protein details for PIGU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H490-PIGU_HUMAN
    Recommended name:
    Phosphatidylinositol glycan anchor biosynthesis class U protein
    Protein Accession:
    Q9H490
    Secondary Accessions:
    • Q7Z489
    • Q8N2F2

    Protein attributes for PIGU Gene

    Size:
    435 amino acids
    Molecular mass:
    50052 Da
    Quaternary structure:
    • Forms a complex with PIGK/GPI8, PIGS, PIGT and GPAA1/GAA1.

    Alternative splice isoforms for PIGU Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIGU Gene

Proteomics data for PIGU Gene at MOPED

Post-translational modifications for PIGU Gene

  • Ubiquitination at Lys 42 and Lys 111
  • Modification sites at PhosphoSitePlus

Other Protein References for PIGU Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PIGU Gene

Domains & Families for PIGU Gene

Gene Families for PIGU Gene

Protein Domains for PIGU Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PIGU Gene

Graphical View of Domain Structure for InterPro Entry

Q9H490

UniProtKB/Swiss-Prot:

PIGU_HUMAN :
  • Belongs to the PIGU family.
Family:
  • Belongs to the PIGU family.
genes like me logo Genes that share domains with PIGU: view

Function for PIGU Gene

Molecular function for PIGU Gene

UniProtKB/Swiss-Prot Function:
Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.

Gene Ontology (GO) - Molecular Function for PIGU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003923 contributes_to GPI-anchor transamidase activity IMP 12802054
GO:0034235 contributes_to GPI anchor binding IMP 12802054
genes like me logo Genes that share ontologies with PIGU: view

Phenotypes for PIGU Gene

genes like me logo Genes that share phenotypes with PIGU: view

Animal Model Products

miRNA for PIGU Gene

miRTarBase miRNAs that target PIGU

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PIGU Gene

Localization for PIGU Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIGU Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIGU Gene COMPARTMENTS Subcellular localization image for PIGU gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for PIGU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005886 plasma membrane IDA 15034568
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane --
GO:0030176 integral component of endoplasmic reticulum membrane IC 12802054
genes like me logo Genes that share ontologies with PIGU: view

Pathways & Interactions for PIGU Gene

SuperPathways for PIGU Gene

Superpath Contained pathways
1 Interleukin receptor SHC signaling
2 PI3K/AKT Signaling in Cancer
3 Development HGF signaling pathway
4 Signaling by Ligand-Responsive EGFR Variants in Cancer
5 Immune System
genes like me logo Genes that share pathways with PIGU: view

UniProtKB/Swiss-Prot Q9H490-PIGU_HUMAN

  • Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis

Gene Ontology (GO) - Biological Process for PIGU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0006506 GPI anchor biosynthetic process IDA 15034568
GO:0016255 attachment of GPI anchor to protein TAS 11483512
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with PIGU: view

No data available for SIGNOR curated interactions for PIGU Gene

Drugs & Compounds for PIGU Gene

(3) Drugs for PIGU Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
sphingosine 1-phosphate Pharma Agonist Endogenous agonist at S1P1-5 0

(841) Additional Compounds for PIGU Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Dehydrosphinganine
  • (2S)-2-amino-1-hydroxyoctadecan-3-one
  • 1-Hydroxy-2-amino-3-oxo-octadecane
  • 2-Amino-1-hydroxy-3-Octadecanone
  • 3-Dehydro-D-sphinganine
  • 3-Dehydrosphinganine
16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
244215-65-4
genes like me logo Genes that share compounds with PIGU: view

Transcripts for PIGU Gene

Unigene Clusters for PIGU Gene

Phosphatidylinositol glycan anchor biosynthesis, class U:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIGU

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIGU Gene

No ASD Table

Relevant External Links for PIGU Gene

GeneLoc Exon Structure for
PIGU
ECgene alternative splicing isoforms for
PIGU

Expression for PIGU Gene

mRNA expression in normal human tissues for PIGU Gene

Protein differential expression in normal tissues from HIPED for PIGU Gene

This gene is overexpressed in Blymphocyte (8.0), Testis (7.8), Monocytes (7.8), and Fetal testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIGU Gene



SOURCE GeneReport for Unigene cluster for PIGU Gene Hs.253319

genes like me logo Genes that share expression patterns with PIGU: view

Protein tissue co-expression partners for PIGU Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PIGU Gene

Orthologs for PIGU Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PIGU Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PIGU 35
  • 93.27 (n)
  • 96.39 (a)
PIGU 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIGU 35
  • 95.17 (n)
  • 98.62 (a)
PIGU 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pigu 35
  • 92.07 (n)
  • 97.36 (a)
Pigu 16
Pigu 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PIGU 35
  • 99.85 (n)
  • 100 (a)
PIGU 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pigu 35
  • 92.39 (n)
  • 97.36 (a)
oppossum
(Monodelphis domestica)
Mammalia PIGU 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIGU 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIGU 35
  • 79.89 (n)
  • 85.34 (a)
PIGU 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIGU 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pigu 35
  • 71.31 (n)
  • 77.88 (a)
zebrafish
(Danio rerio)
Actinopterygii pigu 35
  • 71.87 (n)
  • 76.44 (a)
wufb79e06 35
pigu 36
  • 75 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5070 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008074 35
  • 48.79 (n)
  • 39.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13089 35
  • 49.46 (n)
  • 39.9 (a)
CG13089 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T22C1.3 35
  • 43.9 (n)
  • 27.87 (a)
T22C1.3 36
  • 25 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL273C 35
  • 47.33 (n)
  • 35.57 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E04907g 35
  • 43.97 (n)
  • 34.19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GAB1 35
  • 45.18 (n)
  • 32.95 (a)
GAB1 36
  • 30 (a)
OneToOne
GAB1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G63110 35
  • 48.92 (n)
  • 37.9 (a)
rice
(Oryza sativa)
Liliopsida Os02g0688900 35
  • 46.84 (n)
  • 33.87 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00924 35
  • 52.98 (n)
  • 41.92 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1952.01 35
  • 43.99 (n)
  • 33.33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToOne
Species with no ortholog for PIGU:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIGU Gene

ENSEMBL:
Gene Tree for PIGU (if available)
TreeFam:
Gene Tree for PIGU (if available)

Paralogs for PIGU Gene

Pseudogenes.org Pseudogenes for PIGU Gene

genes like me logo Genes that share paralogs with PIGU: view

No data available for Paralogs for PIGU Gene

Variants for PIGU Gene

Sequence variations from dbSNP and Humsavar for PIGU Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs721612 -- 34,605,678(+) gTCCA(A/C)ATGAA intron-variant
rs721613 -- 34,605,624(+) GTGGA(A/G)GCAGA intron-variant
rs764597 -- 34,573,421(-) TAAAG(C/T)AGCAC intron-variant
rs764598 -- 34,573,346(-) GGATT(C/G)GGGTT intron-variant
rs910873 -- 34,583,968(+) TAGGC(A/G)TATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIGU Gene

Variant ID Type Subtype PubMed ID
nsv3359 CNV Loss 18451855
nsv3360 CNV Insertion 18451855
esv989025 CNV Deletion 20482838
nsv512614 CNV Loss 21212237
esv2546222 CNV Deletion 19546169
esv2722356 CNV Deletion 23290073
esv2672886 CNV Deletion 23128226
nsv180489 CNV Loss 16902084
esv22551 CNV Loss 19812545

Variation tolerance for PIGU Gene

Residual Variation Intolerance Score: 34.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.81; 34.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIGU Gene

HapMap Linkage Disequilibrium report
PIGU

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIGU Gene

Disorders for PIGU Gene

Relevant External Links for PIGU

Genetic Association Database (GAD)
PIGU
Human Genome Epidemiology (HuGE) Navigator
PIGU
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIGU
genes like me logo Genes that share disorders with PIGU: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIGU Gene

Publications for PIGU Gene

  1. Overexpression of CDC91L1 (PIG-U) in bladder urothelial cell carcinoma: correlation with clinical variables and prognostic significance. (PMID: 17941920) Shen Y.J. … Nagpal J. (BJU Int. 2008) 23 67
  2. CDC91L1 (PIG-U) mRNA expression in urothelial cell carcinomas. (PMID: 15800923) Schultz I.J. … de Kok J.B. (Int. J. Cancer 2005) 23 67
  3. A conserved proline in the last transmembrane segment of Gaa1 is required for glycosylphosphatidylinositol (GPI) recognition by GPI transamidase. (PMID: 14660601) Vainauskas S. … Menon A.K. (J. Biol. Chem. 2004) 23 67
  4. CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer. (PMID: 15034568) Guo Z. … Trink B. (Nat. Med. 2004) 2 67
  5. Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. (PMID: 12802054) Hong Y. … Kinoshita T. (Mol. Biol. Cell 2003) 2 67

Products for PIGU Gene

Sources for PIGU Gene

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