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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PIGT Gene

protein-coding   GIFtS: 55
GCID: GC20P044044

Phosphatidylinositol Glycan Anchor Biosynthesis, Class T

(Previous names: phosphatidylinositol glycan, class T)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phosphatidylinositol Glycan Anchor Biosynthesis, Class T1 2     NDAP2
GPI Transamidase Subunit1 2     PNH22
Phosphatidylinositol-Glycan Biosynthesis Class T Protein2 3     GPI Transamidase Component PIG-T2
Phosphatidylinositol Glycan, Class T1     Neurotrophin-Regulated Neuronal Development-Associated Protein2
MCAHS32     

External Ids:    HGNC: 149381   Entrez Gene: 516042   Ensembl: ENSG000001241557   OMIM: 6102725   UniProtKB: Q969N23   

Export aliases for PIGT gene to outside databases

Previous GC identifers: GC20P043773 GC20P044683 GC20P044730 GC20P043478 GC20P040786


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PIGT Gene:
This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The
GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This
protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI
anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.
Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided
by RefSeq, May 2012)

GeneCards Summary for PIGT Gene: 
PIGT (phosphatidylinositol glycan anchor biosynthesis, class T) is a protein-coding gene. Diseases associated with PIGT include neuronitis, and breast cancer, and among its related super-pathways are Post-translational modification: synthesis of GPI-anchored proteins and Post-translational protein modification. GO annotations related to this gene include GPI-anchor transamidase activity and protein binding.

UniProtKB/Swiss-Prot: PIGT_HUMAN, Q969N2
Function: Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for
formation of carbonyl intermediates

Gene Wiki entry for PIGT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PIGT gene promoter:
         AML1a   ATF-2   Lmo2   Nkx2-5   STAT5A   GATA-1   CRE-BP1   MZF-1   HSF2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIGT promoter sequence
   Search SABiosciences Chromatin IP Primers for PIGT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIGT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12-q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q12-q13.12

PIGT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIGT gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P044044:  view genomic region     (about GC identifiers)

Start:
44,044,707 bp from pter      End:
44,054,884 bp from pter
Size:
10,178 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PIGT_HUMAN, Q969N2 (See protein sequence)
Recommended Name: GPI transamidase component PIG-T precursor  
Size: 578 amino acids; 65700 Da
Subunit: Forms a complex with PIGK/GPI8, PIGS, PIGU and GPAA1/GAA1. Has a critical role in maintaining the complex
by stabilizing the expression of GPAA1 and GPI8 and linking them to PIGS
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein
Sequence caution: Sequence=AAD27715.1; Type=Frameshift; Positions=5, 27; Sequence=AAQ88951.1; Type=Erroneous
initiation; Sequence=CAB57341.1; Type=Erroneous initiation;
Secondary accessions: B2RND5 B7Z3N1 B7Z7I8 E1P622 G8JLF5 Q2NL69 Q7Z3N7 Q9BQY7 Q9BQY8 Q9UJG6
Q9Y2Z5
Alternative splicing: 6 isoforms:  Q969N2-1   Q969N2-2   Q969N2-3   Q969N2-4   Q969N2-5   Q969N2-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PIGT: NX_Q969N2

Explore proteomics data for PIGT at MOPED 

Post-translational modifications:

  • UniProtKB: The disulfide bond between PIGK/GPI8 and PIGT is important for normal enzyme activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q969N2

  • PIGT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PIGT Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001171657.1  NP_001171658.1  NP_001171659.1  NP_057021.2  

    ENSEMBL proteins: 
     ENSP00000279036   ENSP00000279035   ENSP00000361774   ENSP00000407574   ENSP00000441577  
     ENSP00000408354   ENSP00000343783   ENSP00000440528   ENSP00000443963  
    Reactome Protein details: Q969N2
    Human Recombinant Protein Products for PIGT: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for PIGT 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--
    GO:0030176integral to endoplasmic reticulum membrane NAS12052837
    GO:0042765GPI-anchor transamidase complex TAS15713669

    PIGT for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for PIGT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PIG: Phosphatidylinositol glycan anchor biosynthesis

    1 InterPro protein domain:
     IPR007245 PIG-T

    Graphical View of Domain Structure for InterPro Entry Q969N2

    ProtoNet protein and cluster: Q969N2

    UniProtKB/Swiss-Prot: PIGT_HUMAN, Q969N2
    Similarity: Belongs to the PIGT family


    PIGT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIGT_HUMAN, Q969N2
    Function: Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for
    formation of carbonyl intermediates

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003923contributes to GPI-anchor transamidase activity TAS11483512
    GO:0005515protein binding IPI11483512
         
    PIGT for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PIGT:
     Upregulation of Wnt/beta-caten 

         1 MGI phenotypic allele for Pigt (no phenotypes)

    PIGT for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pigttm1Lex for PIGT

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PIGT 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PIGT

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    1 QIAGEN miScript miRNA Assays for microRNA that regulate PIGT:
    hsa-miR-659
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PIGT About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Post-translational modification: synthesis of GPI-anchored proteins
    Post-translational modification: synthesis of GPI-anchored proteins0.79
    Glycosylphosphatidylinositol(GPI)-anchor biosynthesis0.79
    2Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.35
    3Metabolism
    Metabolic pathways0.40
    4Attachment of GPI anchor to uPAR
    Attachment of GPI anchor to uPAR

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for PIGT
        Attachment of GPI anchor to uPAR
    Metabolism of proteins
    Post-translational modification: synthesis of GPI-anchored proteins
    Post-translational protein modification


    2         Kegg Pathways  (Kegg details for PIGT):
        Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: PIGT_HUMAN, Q969N2
    Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis


    PIGT for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIGT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/34 Interacting proteins for PIGT (Q969N22, 3 ENSP000002790364) via UniProtKB, MINT, STRING, and/or I2D (see all 34)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UPF3AQ9H1J12, 3, ENSP000003644484MINT-65103 I2D: score=4 STRING: ENSP00000364448
    PIGKQ926433, ENSP000003598484I2D: score=6 STRING: ENSP00000359848
    GPAA1O432923, ENSP000003472064I2D: score=6 STRING: ENSP00000347206
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    C9orf41Q8N4J03I2D: score=5 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006501C-terminal protein lipidation TAS--
    GO:0016255attachment of GPI anchor to protein TAS11483512
    GO:0030182neuron differentiation IEA--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    PIGT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PIGT

    10/898 HMDB Compounds for PIGT (see all 898)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
    3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
    3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
    3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
    3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
    3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
    3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--

    Search CenterWatch for drugs/clinical trials and news about PIGT

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PIGT gene (4 alternative transcripts): 
    NM_001184728.2  NM_001184729.2  NM_001184730.2  NM_015937.5  

    Unigene Cluster for PIGT:

    Phosphatidylinositol glycan anchor biosynthesis, class T
    Hs.437388  [show with all ESTs]
    Unigene Representative Sequence: NM_015937
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000279036(uc010ghd.2 uc010ghc.2 uc010ghe.2 uc010ghf.2 uc002xoh.2 uc010zwu.2 uc002xoi.2 uc010zwv.2 uc010zwx.2 uc010zxa.2)
    ENST00000279035(uc010zwz.2 uc010zwy.2 uc010zxb.1) ENST00000372689(uc010ghb.2 uc010zwt.2 uc002xoj.2 uc002xol.1)
    ENST00000455050 ENST00000543458(uc010zww.2) ENST00000432270 ENST00000341555
    ENST00000535404 ENST00000545755
    miRNA
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    Additional mRNA sequence: 

    AB057724.1 AF058295.1 AF132940.1 AK075469.1 AK225517.1 AK293294.1 AK293686.1 AK296063.1 
    AK296139.1 AK297830.1 AK299013.1 AK301815.1 AK302093.1 AK311100.1 AK311416.1 AK311492.1 
    AK311520.1 AK311522.1 AK316358.1 AL121742.1 AY358588.1 BC015022.1 BC110892.1 BC136827.1 
    BC136828.1 NR_047691.1 NR_047692.1 NR_047693.1 NR_047694.1 NR_047695.1 

    24/29 DOTS entries (see all 29):

    DT.453818  DT.95172646  DT.101985299  DT.100680828  DT.100845646  DT.86851993  DT.100682608  DT.120801350 
    DT.120801361  DT.91761261  DT.100845654  DT.437588  DT.120801311  DT.120801353  DT.95172643  DT.100845640 
    DT.120801316  DT.95172644  DT.100038793  DT.120801281  DT.91761257  DT.91761260  DT.100845643  DT.101985298 

    24/600 AceView cDNA sequences (see all 600):

    BP373149 AA846754 BE781323 CA418025 BM754691 BE298820 BP345557 BQ687050 
    NM_015937 BU543758 BE905445 BU786832 BM922783 AW512535 BI758081 AY358588 
    AU280758 AA305125 CR593007 AL711004 BU838230 AA883953 BQ877507 CF131943 

    GeneLoc Exon Structure

    5/22 Alternative Splicing Database (ASD) splice patterns (SP) for PIGT (see all 22)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a ·
    SP1:                                                              -                 -                       -                                               -   
    SP2:                                                              -                 -     -     -     -     -                                               -   
    SP3:                                                                                -                       -                                               -   
    SP4:                                      -     -     -     -     -     -     -     -                       -                                               -   
    SP5:                                                              -     -     -     -                       -                                                   

    ExUns: 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13
    SP1:                                                                        
    SP2:                                                                        
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for PIGT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PIGT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTACAACG
    PIGT Expression
    About this image


    See PIGT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PIGT

    SOURCE GeneReport for Unigene cluster: Hs.437388
        SABiosciences Custom PCR Arrays for PIGT
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PIGT gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pigt1 , 5 phosphatidylinositol glycan anchor biosynthesis, class more1, 5 87.72(n)1
    94.12(a)1
      2 (85.17 cM)5
    789281  NM_133779.21  NP_598540.21 
     1644975205 
    chicken
    (Gallus gallus)
    Aves PIGT1 phosphatidylinositol glycan anchor biosynthesis, class more 73.76(n)
    76.63(a)
      419179  XM_417358.3  XP_417358.2 
    lizard
    (Anolis carolinensis)
    Reptilia PIGT6
    Uncharacterized protein
    77(a)
    1 ↔ 1
    GL343291.1(1585901-1598304)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA980888.12   -- 75.41(n)    CA980888.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pigt1 phosphatidylinositol glycan anchor biosynthesis, class more 67.76(n)
    69.64(a)
      556667  XM_679516.4  XP_684608.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG111901 CG11190 50.66(n)
    39.92(a)
      31772  NM_132247.3  NP_572475.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F17C11.76
    Protein F17C11.7, isoform b
    25(a)
    1 ↔ 1
    V(10956821-10958823)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GPI16(YHR188C)4
    GPI161
    Transmembrane protein subunit of the glycosylphosphatidylinositol more4
    Gpi16p1
    44.06(n)1
    34.22(a)1
      8(483837-482005)4
    8565951, 4  NP_012058.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G071401 GPI transamidase component Gpi16 subunit-like protein 45.72(n)
    38.3(a)
      819900  NM_111594.3  NP_566299.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g04792321 hypothetical protein 45.19(n)
    36.41(a)
      9271607  NM_001189609.1  NP_001176538.1 


    ENSEMBL Gene Tree for PIGT (if available)
    TreeFam Gene Tree for PIGT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/397 SNPs in PIGT are shown (see all 397)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1389295071,2
    --44042740(+) TCTACA/GTTTAC 9 -- us2k10--------
    rs72634771,2
    C,F--44042802(+) ATTCCA/TTATCC 9 -- us2k11Minor allele frequency- T:0.07WA 118
    rs1927919571,2
    C--44042806(+) CATATC/TCTACA 9 -- us2k10--------
    rs2001923421,2
    C--44042867(+) TTATA-/AAATGA 9 -- us2k10--------
    rs1429398441,2
    --44042953(+) GACATC/TTAAGC 9 -- us2k10--------
    rs1470072661,2
    --44043008(+) GAATGC/TAGGCA 9 -- us2k10--------
    rs1825519431,2
    --44043130(+) TAGAAC/GTGTGG 9 -- us2k10--------
    rs1387394631,2
    --44043133(+) AAGTGG/TGGTCA 9 -- us2k10--------
    rs22512121,2
    C,F,H--44043228(+) ACTTTG/AGAACT 9 -- us2k120Minor allele frequency- A:0.19NS EA NA WA CSA 2346
    rs1391499601,2
    C--44043315(+) AAAAA-/TA    
       AAAAT
    TAAAT
    9 -- us2k10--------

    HapMap Linkage Disequilibrium report for PIGT (44044707 - 44054884 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PIGT:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv912892CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610272    OMIM disorders: --

    2 diseases for PIGT:    About MalaCards
    neuronitis    breast cancer


    PIGT for disorders           About GeneDecksing


    Export disorders for PIGT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PIGT gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with PIGT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge. (PubMed id 12582175)1, 2, 9 Ohishi K.... Kinoshita T. (2003)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    3. Endoplasmic reticulum localization of Gaa1 and PIG-T, subunits of the glycosylphosphatidylinositol transamidase complex. (PubMed id 15713669)1, 3 Vainauskas S. and Menon A.K. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    7. PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8. (PubMed id 11483512)1, 2 Ohishi K.... Kinoshita T. (2001)
    8. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
    9. The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis. (PubMed id 16516892)1, 9 Li H.L....Yu A.C. (2006)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51604 HGNC: 14938 AceView: PIGT Ensembl:ENSG00000124155 euGenes: HUgn51604
    ECgene: PIGT Kegg: 51604 H-InvDB: PIGT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PIGT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PIGT gene:
    Search GeneIP for patents involving PIGT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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