Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PIGS Gene

Aliases for PIGS Gene

  • Phosphatidylinositol Glycan Anchor Biosynthesis Class S 2 3 5
  • Phosphatidylinositol-Glycan Biosynthesis Class S Protein 4
  • Phosphatidylinositol Glycan, Class S 2
  • GPI Transamidase Subunit 2

External Ids for PIGS Gene

Previous GeneCards Identifiers for PIGS Gene

  • GC17M026725
  • GC17M028780
  • GC17M027025
  • GC17M023904
  • GC17M026880
  • GC17M023089

Summaries for PIGS Gene

Entrez Gene Summary for PIGS Gene

  • This gene encodes a protein that is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for PIGS Gene

PIGS (Phosphatidylinositol Glycan Anchor Biosynthesis Class S) is a Protein Coding gene. Among its related pathways are Glycosylphosphatidylinositol (GPI)-anchor biosynthesis and Metabolism of proteins. GO annotations related to this gene include GPI-anchor transamidase activity.

UniProtKB/Swiss-Prot for PIGS Gene

  • Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates.

Gene Wiki entry for PIGS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIGS Gene

Genomics for PIGS Gene

Regulatory Elements for PIGS Gene

Enhancers for PIGS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F028500 1.3 FANTOM5 Ensembl ENCODE 11.5 +70.7 70695 0.4 TBP MAX EBF1 ZIC2 RELA POLR2A EED ZNF207 CHD2 MAZ UNC119 PIGS SPAG5-AS1 SGK494 SLC46A1 KIAA0100 FOXN1 SPAG5 SEBOX TMEM97
GH17F028526 1.2 Ensembl ENCODE 11.8 +43.9 43914 2.3 ATF1 ARNT CBX5 ELK1 GATA2 NCOA1 CREB3 MBD2 MEF2D SMARCA4 UNC119 PIGS FOXN1 ENSG00000265205 GC17P028538
GH17F028380 1.2 Ensembl ENCODE 10.3 +190.8 190776 2.2 PKNOX1 ATF1 SIN3A FEZF1 BRCA1 ZNF207 FOS DEK SP5 ZHX2 IFT20 SLC46A1 TNFAIP1 VTN PIGS ENSG00000279532 GC17M028814
GH17F028546 1 ENCODE 12.3 +21.5 21463 7.7 HDGF PKNOX1 SIN3A GLI4 ZNF48 YY1 GLIS2 ZNF143 DEK SP3 ENSG00000264577 NUFIP2 LOC101927018 PHF12 ENSG00000265205 SDF2 PIGS FOXN1 ALDOC ENSG00000265908
GH17F028393 1.1 Ensembl ENCODE 10.4 +175.0 175006 5.7 BCOR GTF2F1 TBP TFAP4 TAL1 JUN ZFP64 ZMYM3 RARA POLR2A POLDIP2 VTN SARM1 TMEM199 MIR4723 TNFAIP1 IFT20 FOXN1 UNC119 PIGS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PIGS on UCSC Golden Path with GeneCards custom track

Promoters for PIGS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001343410 772 2201 HDGF ATF1 PKNOX1 WRNIP1 ARID4B SIN3A ETS1 YY1 GLIS2 GATA2

Genomic Location for PIGS Gene

Chromosome:
17
Start:
28,553,383 bp from pter
End:
28,571,872 bp from pter
Size:
18,490 bases
Orientation:
Minus strand

Genomic View for PIGS Gene

Genes around PIGS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIGS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIGS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIGS Gene

Proteins for PIGS Gene

  • Protein details for PIGS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S52-PIGS_HUMAN
    Recommended name:
    GPI transamidase component PIG-S
    Protein Accession:
    Q96S52
    Secondary Accessions:
    • Q6UVX6

    Protein attributes for PIGS Gene

    Size:
    555 amino acids
    Molecular mass:
    61656 Da
    Quaternary structure:
    • Forms a complex with PIGK/GPI8, PIGT, PIGU and GAA1.

    Alternative splice isoforms for PIGS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIGS Gene

Post-translational modifications for PIGS Gene

  • Glycosylation at Asn 267 and Asn 370
  • Modification sites at PhosphoSitePlus

Other Protein References for PIGS Gene

No data available for DME Specific Peptides for PIGS Gene

Domains & Families for PIGS Gene

Gene Families for PIGS Gene

Protein Domains for PIGS Gene

Suggested Antigen Peptide Sequences for PIGS Gene

Graphical View of Domain Structure for InterPro Entry

Q96S52

UniProtKB/Swiss-Prot:

PIGS_HUMAN :
  • Belongs to the PIGS family.
Family:
  • Belongs to the PIGS family.
genes like me logo Genes that share domains with PIGS: view

Function for PIGS Gene

Molecular function for PIGS Gene

UniProtKB/Swiss-Prot Function:
Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates.

Gene Ontology (GO) - Molecular Function for PIGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003923 contributes_to GPI-anchor transamidase activity TAS 11483512
GO:0005515 protein binding IPI 11483512
genes like me logo Genes that share ontologies with PIGS: view

Phenotypes for PIGS Gene

genes like me logo Genes that share phenotypes with PIGS: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIGS Gene

Localization for PIGS Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIGS Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIGS gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for PIGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0042765 GPI-anchor transamidase complex IEA,TAS 15713669
genes like me logo Genes that share ontologies with PIGS: view

Pathways & Interactions for PIGS Gene

genes like me logo Genes that share pathways with PIGS: view

UniProtKB/Swiss-Prot Q96S52-PIGS_HUMAN

  • Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.

Gene Ontology (GO) - Biological Process for PIGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006506 GPI anchor biosynthetic process IEA --
GO:0016255 attachment of GPI anchor to protein IEA,TAS 11483512
genes like me logo Genes that share ontologies with PIGS: view

No data available for SIGNOR curated interactions for PIGS Gene

Drugs & Compounds for PIGS Gene

(3) Drugs for PIGS Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
Sphingosine-1-phosphate Pharma Full agonist, Agonist endogenous second messenger and ligand for S1PR1, Endogenous agonist at S1P1-5 0

(841) Additional Compounds for PIGS Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Dehydrosphinganine
  • (2S)-2-amino-1-hydroxyoctadecan-3-one
  • 1-Hydroxy-2-amino-3-oxo-octadecane
  • 2-Amino-1-hydroxy-3-Octadecanone
  • 3-Dehydro-D-sphinganine
  • 3-Dehydrosphinganine
16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
244215-65-4
genes like me logo Genes that share compounds with PIGS: view

Transcripts for PIGS Gene

Unigene Clusters for PIGS Gene

Phosphatidylinositol glycan anchor biosynthesis, class S:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIGS Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13
SP1: - - - -
SP2: - - - -
SP3: - - - - - - - - - - - - -
SP4: - -
SP5: - - -
SP6: - - - -
SP7: -
SP8:
SP9: - -

Relevant External Links for PIGS Gene

GeneLoc Exon Structure for
PIGS
ECgene alternative splicing isoforms for
PIGS

Expression for PIGS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PIGS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PIGS Gene

This gene is overexpressed in Bone (33.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PIGS Gene



Protein tissue co-expression partners for PIGS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PIGS Gene:

PIGS

SOURCE GeneReport for Unigene cluster for PIGS Gene:

Hs.462550
genes like me logo Genes that share expression patterns with PIGS: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PIGS Gene

Orthologs for PIGS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PIGS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIGS 34 35
  • 99.52 (n)
cow
(Bos Taurus)
Mammalia PIGS 34 35
  • 89.67 (n)
dog
(Canis familiaris)
Mammalia PIGS 34 35
  • 89.19 (n)
rat
(Rattus norvegicus)
Mammalia Pigs 34
  • 87.81 (n)
mouse
(Mus musculus)
Mammalia Pigs 34 16 35
  • 87.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PIGS 35
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIGS 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIGS 34 35
  • 66.87 (n)
lizard
(Anolis carolinensis)
Reptilia PIGS 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pigs 34
  • 60.49 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15898 34
zebrafish
(Danio rerio)
Actinopterygii pigs 34 35
  • 59.44 (n)
Dr.17191 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002933 34
  • 47.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31120 34 35
  • 44.59 (n)
worm
(Caenorhabditis elegans)
Secernentea hpo-5 35
  • 20 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR180C 34
  • 42.86 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B01045g 34
  • 40.88 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPI17 34 35 37
  • 40.4 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G07180 34
  • 40.56 (n)
rice
(Oryza sativa)
Liliopsida Os01g0907300 34
  • 41.25 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06033 34
  • 44.15 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gpi17 34
  • 40.77 (n)
Species where no ortholog for PIGS was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIGS Gene

ENSEMBL:
Gene Tree for PIGS (if available)
TreeFam:
Gene Tree for PIGS (if available)

Paralogs for PIGS Gene

(1) SIMAP similar genes for PIGS Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PIGS: view

No data available for Paralogs for PIGS Gene

Variants for PIGS Gene

Sequence variations from dbSNP and Humsavar for PIGS Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_036510 A breast cancer sample
rs1034903 -- 28,561,273(-) attTT(A/T)TTTAG intron-variant
rs111282758 -- 28,558,706(+) AGAGA(C/G)AAAAT intron-variant
rs111284765 -- 28,554,866(+) ACGTC(A/G)TCCTT reference, synonymous-codon
rs111335060 -- 28,554,971(+) AGCCG(A/G)TCTAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for PIGS Gene

Variant ID Type Subtype PubMed ID
nsv1064087 CNV gain 25217958
nsv1064958 CNV loss 25217958

Variation tolerance for PIGS Gene

Residual Variation Intolerance Score: 16.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIGS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIGS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIGS Gene

Disorders for PIGS Gene

Relevant External Links for PIGS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIGS

No disorders were found for PIGS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIGS Gene

Publications for PIGS Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  3. PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8. (PMID: 11483512) Ohishi K. … Kinoshita T. (EMBO J. 2001) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for PIGS Gene

Sources for PIGS Gene

Content
Loading form....