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PIGR Gene

protein-coding   GIFtS: 59
GCID: GC01M207101

Polymeric Immunoglobulin Receptor

  See PIGR-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Polymeric Immunoglobulin Receptor1 2
Hepatocellular Carcinoma-Associated Protein TB62 3
Poly-Ig Receptor2 3
Hepatocellular Carcinoma Associated Protein TB62
PIgR3

External Ids:    HGNC: 89681   Entrez Gene: 52842   Ensembl: ENSG000001628967   OMIM: 1738805   UniProtKB: P018333   

Export aliases for PIGR gene to outside databases

Previous GC identifers: GC01M205761 GC01M202813 GC01M203745 GC01M204185 GC01M203335 GC01M205168 GC01M177799


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PIGR Gene:
This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric
immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across
the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A
nephropathy and several SNPs in this gene.(provided by RefSeq, Sep 2009)

GeneCards Summary for PIGR Gene:
PIGR (polymeric immunoglobulin receptor) is a protein-coding gene. Diseases associated with PIGR include protein-energy malnutrition, and hepatocellular carcinoma. An important paralog of this gene is FAIM3.

UniProtKB/Swiss-Prot: PIGR_HUMAN, P01833
Function: This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is
then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that
separates the extracellular (known as the secretory component) from the transmembrane segment

Gene Wiki entry for PIGR (Polymeric immunoglobulin receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PIGR gene promoter:
         Bach1   USF1   Bach2   USF2   USF-1:USF-2   HNF-1A   HNF-1   USF-1   IRF-7A   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIGR promoter sequence
   Search Chromatin IP Primers for PIGR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIGR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31-q41   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q31-q41

PIGR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIGR gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M207101:  view genomic region     (about GC identifiers)

Start:
207,101,863 bp from pter      End:
207,119,811 bp from pter
Size:
17,949 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PIGR_HUMAN, P01833 (See protein sequence)
Recommended Name: Polymeric immunoglobulin receptor precursor  
Size: 764 amino acids; 83284 Da
4 PDB 3D structures from and Proteopedia for PIGR:
1XED (3D)        2OCW (3D)        3CHN (3D)        3CM9 (3D)    
Secondary accessions: Q68D81 Q8IZY7

Explore the universe of human proteins at neXtProt for PIGR: NX_P01833

Explore proteomics data for PIGR at MOPED

Post-translational modifications: 

  • N-glycosylation is not necessary for Ig binding1
  • Glycosylation2 at Asn83, Asn90, Asn135, Asn186, Asn421, Asn469, Asn499
  • Modification sites at PhosphoSitePlus

  • See PIGR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002635.2  
    ENSEMBL proteins: 
     ENSP00000348888  

    PIGR Human Recombinant Protein Products:

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    antibodies-online proteins for PIGR (40 products) 

     
    antibodies-online peptides for PIGR

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P01833

    ProtoNet protein and cluster: P01833

    2 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: PIGR_HUMAN, P01833
    Similarity: Contains 5 Ig-like V-type (immunoglobulin-like) domains


    Find genes that share domains with PIGR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIGR_HUMAN, P01833
    Function: This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is
    then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that
    separates the extracellular (known as the secretory component) from the transmembrane segment

         Genatlas biochemistry entry for PIGR:
    immunoglobulin polymeric (poly-Ig) receptor,transmembrane secretory complement

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001792polymeric immunoglobulin receptor activity IDA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with PIGR           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Pigr):
     digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system  reproductive system 

    Find genes that share phenotypes with PIGR           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PIGR: Pigrtm1Fejo Pigrtm1Ohw Pigrtm1Rast

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PIGR
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    Selected qRT-PCR Assays for microRNAs that regulate PIGR (see all 9):
    hsa-miR-1321 hsa-miR-634 hsa-miR-219-5p hsa-miR-3921 hsa-miR-1224-5p hsa-miR-508-3p hsa-miR-489 hsa-miR-542-3p
    SwitchGear 3'UTR luciferase reporter plasmidPIGR 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for PIGR 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PIGR_HUMAN, P01833: Cell membrane; Single-pass type I membrane protein
    PIGR_HUMAN, P01833: Secretory component: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    endosome2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IDA--
    GO:0005886plasma membrane IDA--
    GO:0005887integral component of plasma membrane TAS2920039
    GO:0043235receptor complex IDA--

    Find genes that share ontologies with PIGR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PIGR About    
    See pathways by source

    SuperPathContained pathways About
    1Allograft rejection
    Intestinal immune network for IgA production0.41
    2Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway
    3IL4-mediated signaling events
    IL4-mediated signaling events


    Find genes that share SuperPaths with PIGR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for PIGR
        Integrated Breast Cancer Pathway
    IL4-mediated signaling events



    1 Kegg Pathway  (Kegg details for PIGR):
        Intestinal immune network for IgA production

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PIGR
    Interactions:

        GeneGlobe Interaction Network for PIGR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for PIGR (P018333 ENSP000003488884) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD79AP119123, ENSP000002219724I2D: score=2 STRING: ENSP00000221972
    MIS12Q9H0813, ENSP000003705574I2D: score=2 STRING: ENSP00000370557
    CCL5P135013, ENSP000002932724I2D: score=3 STRING: ENSP00000293272
    RAB3BP203373, ENSP000003607184I2D: score=2 STRING: ENSP00000360718
    SGK1O001413, ENSP000003568324I2D: score=2 STRING: ENSP00000356832
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001580detection of chemical stimulus involved in sensory perception of bitter taste IDA--
    GO:0001895retina homeostasis IEP--
    GO:0002415immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor IDA--
    GO:0007173epidermal growth factor receptor signaling pathway IDA--
    GO:0038093Fc receptor signaling pathway IDA--

    Find genes that share ontologies with PIGR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PIGR

    Selected Novoseek inferred chemical compound relationships for PIGR gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pneumococcal 36.1 1 15232164 (1)
    mannose 6-phosphate 34.5 1 7798315 (1)
    leupeptin 27.1 2 15881224 (1), 15270729 (1)
    cycloheximide 26.6 4 8455639 (1), 10227981 (1), 9182878 (1)
    mycophenolic acid 24.1 8 15103747 (4)
    nocodazole 19.3 1 2277063 (1)
    pyruvate 10 2 19323455 (1), 15822913 (1)
    calcium 0 4 8655590 (1), 10233153 (1), 9658171 (1), 11169207 (1)
    tyrosine 0 10 9658171 (3), 10233153 (1), 10227981 (1), 15616594 (1)
    leucine 0 1 14644095 (1)



    Find genes that share compounds with PIGR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PIGR gene: 
    NM_002644.3  

    Unigene Cluster for PIGR:

    Polymeric immunoglobulin receptor
    Hs.497589  [show with all ESTs]
    Unigene Representative Sequence: CR749533
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356495(uc001hez.3 uc009xbz.3) ENST00000487208 ENST00000491503

    miRNA
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    hsa-miR-1321 hsa-miR-634 hsa-miR-219-5p hsa-miR-3921 hsa-miR-1224-5p hsa-miR-508-3p hsa-miR-489 hsa-miR-542-3p
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    Additional mRNA sequence: 

    AF272149.2 AK225471.1 AK310199.1 AY178835.1 BC110061.1 BC110494.2 BC110495.2 CR749533.1 
    M24559.1 S62403.1 X73079.1 

    11 DOTS entries:

    DT.100642770  DT.108585  DT.100740986  DT.100038090  DT.95276505  DT.95313059  DT.100842666  DT.95137296 
    DT.120883236  DT.91747093  DT.95179289 

    Selected AceView cDNA sequences (see all 321):

    AF272149 BX486244 BQ083836 AI433393 BX486838 BX487927 BX482239 AI889437 
    AW577877 AI833092 AW001735 AA555209 AI633999 BQ082964 BM817942 CD722167 
    NM_002644 AA316565 BX506826 BX950937 CA435840 AW361993 CD615322 AW273755 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PIGR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCCAAGAT
    PIGR Expression
    About this image


    PIGR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts
     
     Lung (Respiratory System)
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
    PIGR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIGR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.497589
        Custom PCR Arrays for PIGR
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PIGR gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pigr1 , 5 polymeric immunoglobulin receptor1, 5 75.98(n)1
    66.01(a)1
      1 (56.89 cM)5
    187031  NM_011082.31  NP_035212.21 
     1308266845 
    chicken
    (Gallus gallus)
    Aves PIGR1 polymeric immunoglobulin receptor 53.47(n)
    42.73(a)
      419848  NM_001044644.1  NP_001038109.1 
    lizard
    (Anolis carolinensis)
    Reptilia PIGR6
    polymeric immunoglobulin receptor
    36(a)
    1 ↔ 1
    GL343228.1(1970265-1984974)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004954531 polymeric immunoglobulin receptor-like 46.77(n)
    36.77(a)
      100495453  XM_002932134.2  XP_002932180.1 


    ENSEMBL Gene Tree for PIGR (if available)
    TreeFam Gene Tree for PIGR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PIGR gene
    FAIM32  FCAMR2  

    Find genes that share paralogs with PIGR           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PIGR (see all 486)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2911021,2,,4
    C,F,O,A,Hunknown1213911462(-) AGACGC/TTGCTC 2 A V mis1 ese329Minor allele frequency- G:0.00MN NS EA NA WA CSA EU 10036
    rs346875711,2
    C--207102415(+) AAAAA-/AATTAGC 1 -- ut311Minor allele frequency- AA:0.00NA 2
    rs725706031,2
    C--207108192(+) TATAC-/ATATATA 1 -- int10--------
    rs715700501,2
    C--207108193(+) ATACATA/-TATAT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs743372321,2
    --207108193(+) ATACAC/TATATA 1 -- int10--------
    rs746536301,2
    C--207108204(+) TATAT-/ATTTTTG 1 -- int11Minor allele frequency- AT:0.00NA 2
    rs583680901,2
    C--207110415(+) CCCCC-/CTCCCT 1 -- int10--------
    rs730724321,2
    C--207121111(+) CCCCCC/GCAACA 1 -- us2k10--------
    rs1385287541,2
    --213906492(+) CAGTGA/GCTCAC 1 -- ds50010--------
    rs1440331171,2
    --213906635(+) GGACGC/TCTGTA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for PIGR (207101863 - 207119811 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PIGR:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv268029CNV Insertion20981092
    nsv468049CNV Loss19166990

    Human Gene Mutation Database (HGMD): PIGR
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PIGR
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 173880    OMIM disorders: --

    2 diseases for PIGR:    
    About MalaCards
    protein-energy malnutrition    hepatocellular carcinoma


    Find genes that share disorders with PIGR           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PIGR gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon carcinoma 42.1 7 8227356 (1), 9973374 (1), 10799857 (1), 7997243 (1) (see all 5)
    nephropathy iga 38.9 2 11579946 (1), 11579940 (1)
    protein-energy malnutrition 23.9 3 9082026 (2), 9800951 (1)
    ebv infections 21.8 4 16086865 (1), 12581959 (1)
    nasopharyngeal carcinoma 16.3 3 12581959 (2)
    adenocarcinoma 14.6 8 15864740 (3), 15881224 (1), 8398172 (1), 8537046 (1) (see all 5)
    inflammatory bowel diseases 6.51 1 14644095 (1)
    necrosis 0.941 13 10803841 (2), 18363466 (1), 19079204 (1), 17971154 (1) (see all 5)
    lung carcinoma 0.853 4 15864740 (2), 8398172 (1)
    carcinoma squamous cell 0 4 15864740 (3), 8398172 (1)

    Genetic Association Database (GAD): PIGR
    Human Genome Epidemiology (HuGE) Navigator: PIGR (7 documents)

    Export disorders for PIGR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIGR gene, integrated from 10 sources (see all 193):
    (articles sorted by number of sources associating them with PIGR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of a polymeric immunoglobulin binding fragment of the human polymeric immunoglobulin receptor. (PubMed id 15530357)1, 2, 9 Hamburger A.E.... Bjorkman P.J. (Structure 2004)
    2. [Correlation of polymeric immunoglobulin receptor gene polymorphisms to susceptibility of nasopharyngeal carcinoma]. (PubMed id 16086865)1, 4, 9 Fan Q....Zeng Y.X. (Ai Zheng 2005)
    3. Association of gene polymorphism of polymeric immunoglobulin receptor and IgA nephropathy. (PubMed id 11579946)1, 4, 9 Narita I....Gejyo F. (Intern. Med. 2001)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (J. Proteome Res. 2006)
    6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    7. A proteomic analysis of human bile. (PubMed id 15084671)1, 2 Kristiansen T.Z.... Pandey A. (Mol. Cell. Proteomics 2004)
    8. Polymeric immunoglobulin receptor polymorphisms and risk of nasopharyngeal cancer. (PubMed id 12546713)1, 4 Hirunsatit R....Mutirangura A. (BMC Genet. 2003)
    9. Association of single-nucleotide polymorphisms in the polymeric immunoglobulin receptor gene with immunoglobulin A nephropathy (IgAN) in Japanese patients. (PubMed id 12740691)1, 4 Obara W....Nakamura Y. (J. Hum. Genet. 2003)
    10. Human free secretory component is composed of the first 585 amino acid residues of the polymeric immunoglobulin receptor. (PubMed id 9237679)1, 2 Hughes G.J....Jaton J.-C. (FEBS Lett. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5284 HGNC: 8968 AceView: PIGR Ensembl:ENSG00000162896 euGenes: HUgn5284
    ECgene: PIGR Kegg: 5284 H-InvDB: PIGR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PIGR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PIGR gene:
    Search GeneIP for patents involving PIGR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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