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Aliases for PIGR Gene

Aliases for PIGR Gene

  • Polymeric Immunoglobulin Receptor 2 3 5
  • Hepatocellular Carcinoma-Associated Protein TB6 4
  • Poly-Ig Receptor 4
  • PIgR 4

External Ids for PIGR Gene

Previous GeneCards Identifiers for PIGR Gene

  • GC01M205761
  • GC01M202813
  • GC01M203745
  • GC01M204185
  • GC01M203335
  • GC01M205168
  • GC01M207101
  • GC01M177799

Summaries for PIGR Gene

Entrez Gene Summary for PIGR Gene

  • This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]

GeneCards Summary for PIGR Gene

PIGR (Polymeric Immunoglobulin Receptor) is a Protein Coding gene. Diseases associated with PIGR include periampullary adenocarcinoma and protein-energy malnutrition. Among its related pathways are Integrated Breast Cancer Pathway and Allograft rejection. GO annotations related to this gene include polymeric immunoglobulin receptor activity. An important paralog of this gene is FCAMR.

UniProtKB/Swiss-Prot for PIGR Gene

  • This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

Gene Wiki entry for PIGR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIGR Gene

Genomics for PIGR Gene

Regulatory Elements for PIGR Gene

Genomic Location for PIGR Gene

Chromosome:
1
Start:
206,928,518 bp from pter
End:
206,946,466 bp from pter
Size:
17,949 bases
Orientation:
Minus strand

Genomic View for PIGR Gene

Genes around PIGR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIGR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIGR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIGR Gene

Proteins for PIGR Gene

  • Protein details for PIGR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01833-PIGR_HUMAN
    Recommended name:
    Polymeric immunoglobulin receptor
    Protein Accession:
    P01833
    Secondary Accessions:
    • Q68D81
    • Q8IZY7

    Protein attributes for PIGR Gene

    Size:
    764 amino acids
    Molecular mass:
    83284 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PIGR Gene

neXtProt entry for PIGR Gene

Proteomics data for PIGR Gene at MOPED

Post-translational modifications for PIGR Gene

  • N-glycosylation is not necessary for Ig binding.
  • Glycosylation at Asn 83, Asn 90, Asn 135, Asn 186, Asn 421, Asn 469, and Asn 499
  • Modification sites at PhosphoSitePlus

Other Protein References for PIGR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PIGR Gene

Domains & Families for PIGR Gene

Gene Families for PIGR Gene

Protein Domains for PIGR Gene

Suggested Antigen Peptide Sequences for PIGR Gene

Graphical View of Domain Structure for InterPro Entry

P01833

UniProtKB/Swiss-Prot:

PIGR_HUMAN :
  • Contains 5 Ig-like V-type (immunoglobulin-like) domains.
Domain:
  • Contains 5 Ig-like V-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with PIGR: view

Function for PIGR Gene

Molecular function for PIGR Gene

GENATLAS Biochemistry:
immunoglobulin polymeric (poly-Ig) receptor,transmembrane secretory complement
UniProtKB/Swiss-Prot Function:
This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
genes like me logo Genes that share phenotypes with PIGR: view

Animal Models for PIGR Gene

MGI Knock Outs for PIGR:

Animal Model Products

CRISPR Products

miRNA for PIGR Gene

miRTarBase miRNAs that target PIGR

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIGR Gene

Localization for PIGR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIGR Gene

Cell membrane; Single-pass type I membrane protein.
Secretory component: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIGR Gene COMPARTMENTS Subcellular localization image for PIGR gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 2
endosome 2
golgi apparatus 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PIGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 2920039
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PIGR: view

Pathways & Interactions for PIGR Gene

genes like me logo Genes that share pathways with PIGR: view

Pathways by source for PIGR Gene

Gene Ontology (GO) - Biological Process for PIGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 24248522
GO:0001895 retina homeostasis IEP 23580065
GO:0007173 epidermal growth factor receptor signaling pathway IDA 22022593
GO:0043113 receptor clustering IDA 22022593
genes like me logo Genes that share ontologies with PIGR: view

No data available for SIGNOR curated interactions for PIGR Gene

Drugs & Compounds for PIGR Gene

(10) Drugs for PIGR Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for PIGR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PIGR: view

Transcripts for PIGR Gene

Unigene Clusters for PIGR Gene

Polymeric immunoglobulin receptor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIGR Gene

No ASD Table

Relevant External Links for PIGR Gene

GeneLoc Exon Structure for
PIGR
ECgene alternative splicing isoforms for
PIGR

Expression for PIGR Gene

mRNA expression in normal human tissues for PIGR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIGR Gene

This gene is overexpressed in Colon - Transverse (x26.3), Minor Salivary Gland (x10.5), and Small Intestine - Terminal Ileum (x5.5).

Protein differential expression in normal tissues from HIPED for PIGR Gene

This gene is overexpressed in Milk (25.3), Pancreatic juice (15.6), and Lavage (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PIGR Gene



SOURCE GeneReport for Unigene cluster for PIGR Gene Hs.497589

genes like me logo Genes that share expression patterns with PIGR: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PIGR Gene

Orthologs for PIGR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PIGR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIGR 35
  • 99.04 (n)
  • 98.04 (a)
PIGR 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PIGR 36
  • 68 (a)
OneToOne
PIGR 35
  • 76.68 (n)
  • 67.46 (a)
dog
(Canis familiaris)
Mammalia PIGR 35
  • 79.05 (n)
  • 69.43 (a)
PIGR 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pigr 16
Pigr 36
  • 64 (a)
OneToOne
Pigr 35
  • 75.98 (n)
  • 66.01 (a)
oppossum
(Monodelphis domestica)
Mammalia PIGR 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIGR 36
  • 47 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pigr 35
  • 75.81 (n)
  • 64.7 (a)
chicken
(Gallus gallus)
Aves PIGR 35
  • 53.47 (n)
  • 42.73 (a)
PIGR 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIGR 36
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495453 35
  • 46.77 (n)
  • 36.77 (a)
Species with no ortholog for PIGR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PIGR Gene

ENSEMBL:
Gene Tree for PIGR (if available)
TreeFam:
Gene Tree for PIGR (if available)

Paralogs for PIGR Gene

Paralogs for PIGR Gene

genes like me logo Genes that share paralogs with PIGR: view

Variants for PIGR Gene

Sequence variations from dbSNP and Humsavar for PIGR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs291102 - 206,933,133(-) AGACG(C/T)TGCTC reference, missense
rs2275531 - 206,935,771(-) CAGGA(A/G)GCTCT reference, missense
rs7542760 - 206,934,461(+) CTGCA(A/G)TCTCT reference, missense
rs13190 -- 206,928,948(-) GGCCC(A/T)GAAGC utr-variant-3-prime
rs291090 -- 206,940,692(-) ATTTA(C/T)GTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIGR Gene

Variant ID Type Subtype PubMed ID
nsv468049 CNV Loss 19166990
esv268029 CNV Insertion 20981092

Variation tolerance for PIGR Gene

Residual Variation Intolerance Score: 39.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.31; 88.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIGR Gene

HapMap Linkage Disequilibrium report
PIGR
Human Gene Mutation Database (HGMD)
PIGR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIGR Gene

Disorders for PIGR Gene

MalaCards: The human disease database

(2) MalaCards diseases for PIGR Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search PIGR in MalaCards View complete list of genes associated with diseases

Relevant External Links for PIGR

Genetic Association Database (GAD)
PIGR
Human Genome Epidemiology (HuGE) Navigator
PIGR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIGR
genes like me logo Genes that share disorders with PIGR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIGR Gene

Publications for PIGR Gene

  1. Crystal structure of a polymeric immunoglobulin binding fragment of the human polymeric immunoglobulin receptor. (PMID: 15530357) Hamburger A.E. … Bjorkman P.J. (Structure 2004) 3 4 23 67
  2. Human Fcalpha/muR and pIgR distribute differently in intestinal tissues. (PMID: 19338768) Wang R. … Zhang W. (Biochem. Biophys. Res. Commun. 2009) 3 23
  3. Down-regulation of the polymeric immunoglobulin receptor in non-small cell lung carcinoma: correlation with dysregulated expression of the transcription factors USF and AP2. (PMID: 15864740) Khattar N.H. … Kaetzel C.S. (J. Biomed. Sci. 2005) 3 23
  4. Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses. (PMID: 15972671) Schneeman T.A. … Kaetzel C.S. (J. Immunol. 2005) 3 23
  5. The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces. (PMID: 16048543) Kaetzel C.S. (Immunol. Rev. 2005) 3 23

Products for PIGR Gene

Sources for PIGR Gene

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