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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PIGQ Gene

protein-coding   GIFtS: 57
GCID: GC16P000616

phosphatidylinositol glycan anchor biosynthesis, class Q

(Previous names: phosphatidylinositol glycan, class Q )
 Explore 2 diseases affiliated with
PIGQ via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PIGQ    

Aliases
for PIGQ gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Phosphatidylinositol Glycan Anchor Biosynthesis, Class Q1 2     HGPI11
GPI11 2 3     C407A10.11
Phosphatidylinositol Glycan, Class Q1 2     C407A10.1 (GPI1 (N-Acetylglucosaminyl Transferase Component))2
Phosphatidylinositol-Glycan Biosynthesis Class Q Protein2 3     N-Acetylglucosaminyl Transferase Component Gpi12
PIG-Q2 3     Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit Q2
N-Acetylglucosamyl Transferase Component GPI12 3     EC 2.4.1.1983

External Ids:    HGNC: 141351   Entrez Gene: 90912   Ensembl: ENSG000000075417   OMIM: 6057545   UniProtKB: Q9BRB33   

Export aliases for PIGQ gene to outside databases

Previous GC identifers: GC16P000639 GC16P000560 GC16P000541 GC16P000617


Summaries
for PIGQ gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PIGQ:
This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a
glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a
N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine
(GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). Alternatively spliced transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Jun 2012)

UniProtKB/Swiss-Prot: PIGQ_HUMAN, Q9BRB3
Function: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to
phosphatidylinositol, the first step of GPI biosynthesis

Gene Wiki entry for PIGQ


Genomic Views
for PIGQ gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PIGQ gene promoter:
         ER-alpha   Pax-6   HSF1 (long)   LUN-1   HNF-3beta   AREB6   IRF-2   HSF1short   c-Myb   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PIGQ promoter sequence
   Search SABiosciences Chromatin IP Primers for PIGQ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIGQ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

PIGQ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIGQ gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P000616:  view genomic region     (about GC identifiers)

Start:
 616,995 bp from pter      End:
 634,136 bp from pter
Size:
 17,142 bases      Orientation:
 plus strand

Proteins
for PIGQ gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PIGQ_HUMAN, Q9BRB3 (See protein sequence)
Recommended Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q  
Size: 760 amino acids; 84082 Da
Subunit: Associates with PIGA, PIGC, PIGH, PIGP and DPM2. The latter is not essential for activity
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A2IDE1 D3DU52 O14927 Q96G00 Q96S22 Q9UJH4
Alternative splicing: 3 isoforms:  Q9BRB3-1   Q9BRB3-2   Q9BRB3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PIGQ: NX_Q9BRB3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BRB3

    • PIGQ Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_004195.2  NP_683721.1  

    ENSEMBL proteins: 
     ENSP00000293874   ENSP00000386760   ENSP00000386554   ENSP00000413753   ENSP00000326674  
     ENSP00000387820   ENSP00000026218   ENSP00000439650   ENSP00000410434   ENSP00000409341  
     ENSP00000439374  
    Reactome Protein details: Q9BRB3
    Human Recombinant Protein Products: 
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    Uscn Proteins for PIGQ

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000506glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IEA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral to membrane IEA--


    PIGQ for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PIGQ

    Protein Domains /
    Families
    for PIGQ gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PIGQ for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007720 GlcNAc_Gpi1

    Graphical View of Domain Structure for InterPro Entry Q9BRB3

    ProtoNet protein and cluster: Q9BRB3

    UniProtKB/Swiss-Prot: PIGQ_HUMAN, Q9BRB3
    Similarity: Belongs to the PIGQ family


    Function
    for PIGQ gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PIGQ_HUMAN, Q9BRB3
    Function: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to
    phosphatidylinositol, the first step of GPI biosynthesis
    Catalytic activity: UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP +
    6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol

    Enzyme Number (IUBMB): EC 2.4.1.1981

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017176phosphatidylinositol N-acetylglucosaminyltransferase activity IEA--


    PIGQ for ontologies           About GeneDecksing



    Pathways & Interactions
    for PIGQ gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Post-translational modification: synthesis of GPI-anchored proteins
    		Post-translational modification: synthesis of GPI-anchored proteins1.00
    		Synthesis of glycosylphosphatidylinositol (GPI)0.64
    		Glycosylphosphatidylinositol(GPI)-anchor biosynthesis0.79
    2Asparagine N-linked glycosylation
    		Post-translational protein modification0.44
    		Metabolism of proteins0.15
    3Metabolism
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for PIGQ
        Metabolism of proteins
    Post-translational modification: synthesis of GPI-anchored proteins
    Post-translational protein modification
    Synthesis of glycosylphosphatidylinositol (GPI)


    2         Kegg Pathways  (Kegg details for PIGQ):
        Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: PIGQ_HUMAN, Q9BRB3
    Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis


    PIGQ for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIGQ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/31 Interacting proteins for PIGQ (Q9BRB32, 3 ENSP000000262184) via UniProtKB, MINT, STRING, and/or I2D (see all 31)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD1Q157972, 3MINT-62013 I2D: score=3 
    PIGCQ925353, ENSP000002583244I2D: score=3 STRING: ENSP00000258324
    TSG101Q998163, ENSP000002519684I2D: score=1 STRING: ENSP00000251968
    PIGPP570543, ENSP000004200374I2D: score=1 STRING: ENSP00000420037
    PIGAP372873, ENSP000003698204I2D: score=3 STRING: ENSP00000369820
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS9729469
    GO:0006501C-terminal protein lipidation TAS--
    GO:0006506GPI anchor biosynthetic process ----
    GO:0016254preassembly of GPI anchor in ER membrane TAS--
    GO:0043687post-translational protein modification TAS--


    PIGQ for ontologies           About GeneDecksing



    Drugs & Compounds
    for PIGQ gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PIGQ

    10/898 HMDB Compounds for PIGQ (see all 898)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
    3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
    3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
    3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
    3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
    3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
    3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--
    Search CenterWatch for drugs/clinical trials and news about PIGQ 

    Transcripts
    for PIGQ gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PIGQ gene (2 alternative transcripts): 
    NM_004204.3  NM_148920.2  

    Unigene Cluster for PIGQ:

    Phosphatidylinositol glycan anchor biosynthesis, class Q
    Hs.644153  [show with all ESTs]
    Unigene Representative Sequence: NM_004204
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000293874 ENST00000409527 ENST00000409439 ENST00000422307 ENST00000321878(uc010bqw.3 uc002chn.3 uc002cho.3 uc010uui.2)
    ENST00000439574 ENST00000026218 ENST00000470411(uc002chm.3) ENST00000443147
    ENST00000544860 ENST00000537901 ENST00000420990 ENST00000480424 ENST00000540241
    ENST00000476438(uc002chp.3) ENST00000540548

    miRNA
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB003723.1 AF030177.1 AK314361.1 BC006377.2 

    11 DOTS entries:

    DT.92429646  DT.444789  DT.100791479  DT.100791471  DT.100791478  DT.95170514  DT.97855924  DT.95081192 
    DT.100775014  DT.100791470  DT.40131829 

    24/182 AceView cDNA sequences (see all 182):

    F37194 BU738432 AK093527 CD674991 BQ073528 BQ679190 R41932 AX748186 
    CA488552 AI061227 T30146 BC032015 F28959 BC006377 AI951411 AW452437 
    CD674376 BC048340 AL039837 CD368383 NM_148920 AU099270 BQ889806 BI870475 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PIGQ    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                                                                    
    SP2:                                                                                    
    SP3:                                                                    -               
    SP4:                                                                                    


    ECgene alternative splicing isoforms for PIGQ

    Expression
    for PIGQ gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PIGQ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCCTCCCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PIGQ expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PIGQ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PIGQ

    SOURCE GeneReport for Unigene cluster: Hs.644153
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    In Situ
    Assay Products:     
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    Orthologs
    for PIGQ gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PIGQ gene from 8/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Pigq1 , 5 phosphatidylinositol glycan anchor biosynthesis, class more1, 5 81.35(n)1
    83.65(a)1    		   17 (13.01 cM)5
    147551  NM_011822.31  NP_035952.21 
     259264275 
    chicken
    (Gallus gallus)    		 Aves PIGQ1 phosphatidylinositol glycan anchor biosynthesis, class more 71.84(n)
    71.9(a)    		   770171  XM_001232059.2  XP_001232060.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PIGQ6
    		 --
    		 71(a)
    		 1 ↔ 1
    		 GL344333.1(5370-41010)
    zebrafish
    (Danio rerio)    		 Actinopterygii sbcb3592 sbcb359 73.77(n)   321218  BC053210.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Gpi13 GPI anchor biosynthesis 34(a)   14B18   --
    worm
    (Caenorhabditis elegans)    		 Secernentea F01G4.51 Protein F01G4.5 43.73(n)
    34.86(a)    		   178019  NM_069685.2  NP_502086.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G571706
    		 N-acetylglucosaminyl transferase component family ...
    		 17(a)
    		 1 ↔ 1
    		 3(21159407-21163184)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 N-acetylglucosaminyl transferase component, putati...
    		 16(a)
    		 1 ↔ 1
    		 5(12618080-12629068)


    ENSEMBL Gene Tree for PIGQ (if available)
    TreeFam Gene Tree for PIGQ (if available) 

    Paralogs
    for PIGQ gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PIGQ gene

    PIGQ for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PIGQ
    PGOHUM00000244039


    Genomic Variants
    for PIGQ gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/420 NCBI SNPs in PIGQ are shown (see all 420)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs748315221,2
    		F--551699(+) AGACTT/AGAGGT 1 -- int12Minor allele frequency- A:0.50NA 6
    rs1881249381,2
    		--618483(+) TCACCA/GCGGGA 3 -- us2k1 ut310--------
    rs1472636771,2
    		--618577(+) GGCTCA/GAGTTC 3 -- us2k1 ut310--------
    rs37600511,2
    		C--618851(+) AATCGG/AGGGCA 3 -- us2k1 ut312Minor allele frequency- A:0.00EA NA 752
    rs20975391,2
    		C,F,H--618966(+) CTCCAG/TTAGCT 3 -- us2k1 ut316Minor allele frequency- T:0.00NS EA NA 694
    rs734813961,2
    		C,--619390(+) CCTGTG/ATCACA 3 -- us2k1 ut311Minor allele frequency- A:0.50WA 2
    rs740039901,2
    		C,--619483(+) AAACGG/AAGTTG 3 -- us2k1 ut312Minor allele frequency- A:0.04WA 120
    rs1435797251,2
    		--619766(+) GGTTCC/TACGAA 3 -- us2k1 int10--------
    rs1512058741,2
    		C,--619822(+) GGGCT-/GGCGGC
    CCGGAGGCA    GGCGG     		3 -- us2k1 int10--------
    rs38339591,2
    		C--619840(+) CAGGCGGCCCGGA
    GGCAGGC    /-    TCGGG     		3 -- us2k1 int11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for PIGQ (616995 - 634136 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for PIGQ
         6 CNVs: 3987 4913 29984 5329 29983 4914
         2 Indels: 25656 61484

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for PIGQ gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PIGQ for disorders           About GeneDecksing

    OMIM gene information: 605754    OMIM disorders: --

    2 diseases for PIGQ:    About MalaCards
    scrapie    malaria

    Human Genome Epidemiology (HuGE) Navigator: PIGQ (2 documents)

    Export disorders for PIGQ gene to outside databases

    Publications
    for PIGQ gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PIGQ gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with PIGQ)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants. (PubMed id 9729469)1, 2, 3, 9 Tiede A.... Schmidt R.E. (1998)
    2. The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1. (PubMed id 9463366)1, 2, 3 Watanabe R....Kinoshita T. (1998)
    3. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. (PubMed id 10944123)1, 2, 9 Watanabe R.... Kinoshita T. (2000)
    4. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (2001)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1 Oguri M....Yamada Y. (2010)
    9. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1 Yoshida T....Yamada Y. (2010)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    External Searches for PIGQ gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PIGQ gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9091 HGNC: 14135 AceView: PIGQandFLJ36208 Ensembl:ENSG00000007541 euGenes: HUgn9091
    ECgene: PIGQ Kegg: 9091 H-InvDB: PIGQ

    Other Databases showing PIGQ gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PIGQ gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PIGQ Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PIGQ gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PIGQ gene:
    Search GeneIP for patents involving PIGQ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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