Aliases for PIGQ Gene
External Ids for PIGQ Gene
Previous GeneCards Identifiers for PIGQ Gene
This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
GeneCards Summary for PIGQ Gene
PIGQ (Phosphatidylinositol Glycan Anchor Biosynthesis, Class Q) is a Protein Coding gene. Diseases associated with PIGQ include ohtahara syndrome. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include phosphatidylinositol N-acetylglucosaminyltransferase activity.
UniProtKB/Swiss-Prot for PIGQ Gene
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis