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PIGQ Gene

protein-coding   GIFtS: 57
GCID: GC16P000616

Phosphatidylinositol Glycan Anchor Biosynthesis, Class Q

(Previous names: phosphatidylinositol glycan, class Q)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phosphatidylinositol Glycan Anchor Biosynthesis, Class Q1 2     c407A10.12
Phosphatidylinositol Glycan, Class Q1 2     C407A10.1 (GPI1 (N-Acetylglucosaminyl Transferase Component))2
Phosphatidylinositol-Glycan Biosynthesis Class Q Protein2 3     N-Acetylglucosaminyl Transferase Component Gpi12
GPI12 3     Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit Q2
PIG-Q2 3     EC 2.4.1.1983
N-Acetylglucosamyl Transferase Component GPI12 3     

External Ids:    HGNC: 141351   Entrez Gene: 90912   Ensembl: ENSG000000075417   OMIM: 6057545   UniProtKB: Q9BRB33   

Export aliases for PIGQ gene to outside databases

Previous GC identifers: GC16P000639 GC16P000560 GC16P000541 GC16P000617


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PIGQ Gene:
This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor
is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a
N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of
N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). Alternatively spliced transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jun 2012)

GeneCards Summary for PIGQ Gene:
PIGQ (phosphatidylinositol glycan anchor biosynthesis, class Q) is a protein-coding gene. Diseases associated with PIGQ include scrapie, and hypertension. GO annotations related to this gene include phosphatidylinositol N-acetylglucosaminyltransferase activity.

UniProtKB/Swiss-Prot: PIGQ_HUMAN, Q9BRB3
Function: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to
phosphatidylinositol, the first step of GPI biosynthesis

Gene Wiki entry for PIGQ Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PIGQ gene promoter:
         ER-alpha   Pax-6   HSF1 (long)   LUN-1   HNF-3beta   AREB6   IRF-2   HSF1short   c-Myb   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIGQ promoter sequence
   Search Chromatin IP Primers for PIGQ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIGQ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

PIGQ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIGQ gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P000616:  view genomic region     (about GC identifiers)

Start:
616,995 bp from pter      End:
634,136 bp from pter
Size:
17,142 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PIGQ_HUMAN, Q9BRB3 (See protein sequence)
Recommended Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q  
Size: 760 amino acids; 84082 Da
Subunit: Associates with PIGA, PIGC, PIGH, PIGP and DPM2. The latter is not essential for activity
Secondary accessions: A2IDE1 D3DU52 O14927 Q96G00 Q96S22 Q9UJH4
Alternative splicing: 3 isoforms:  Q9BRB3-1   Q9BRB3-2   Q9BRB3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PIGQ: NX_Q9BRB3

Explore proteomics data for PIGQ at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys563
  • Modification sites at PhosphoSitePlus

  • See PIGQ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004195.2  NP_683721.1  

    ENSEMBL proteins: 
     ENSP00000293874   ENSP00000386760   ENSP00000386554   ENSP00000413753   ENSP00000326674  
     ENSP00000387820   ENSP00000026218   ENSP00000439650   ENSP00000410434   ENSP00000409341  
     ENSP00000439374  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PIG: Phosphatidylinositol glycan anchor biosynthesis

    1 InterPro protein domain:
     IPR007720 GlcNAc_Gpi1

    Graphical View of Domain Structure for InterPro Entry Q9BRB3

    ProtoNet protein and cluster: Q9BRB3

    UniProtKB/Swiss-Prot: PIGQ_HUMAN, Q9BRB3
    Similarity: Belongs to the PIGQ family


    PIGQ for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIGQ_HUMAN, Q9BRB3
    Function: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to
    phosphatidylinositol, the first step of GPI biosynthesis
    Catalytic activity: UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP +
    6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol

         Enzyme Number (IUBMB): EC 2.4.1.1981

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017176phosphatidylinositol N-acetylglucosaminyltransferase activity IEA--
         
    PIGQ for ontologies           About GeneDecksing


    Animal Models:
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    hsa-mir-222-3p (MIRT046809)

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    SwitchGear 3'UTR luciferase reporter plasmidPIGQ 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PIGQ_HUMAN, Q9BRB3: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    plasma membrane3
    cytosol1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000506glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IEA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--

    PIGQ for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PIGQ About    
    See pathways by source

    SuperPathContained pathways About
    1Post-translational modification- synthesis of GPI-anchored proteins
    Post-translational modification- synthesis of GPI-anchored proteins0.76
    Synthesis of glycosylphosphatidylinositol (GPI)0.00
    Glycosylphosphatidylinositol(GPI)-anchor biosynthesis0.76
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30
    3Metabolism
    Metabolic pathways0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for PIGQ):
        Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: PIGQ_HUMAN, Q9BRB3
    Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis


    PIGQ for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PIGQ
    Interactions:

        GeneGlobe Interaction Network for PIGQ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PIGQ (Q9BRB32, 3 ENSP000000262184) via UniProtKB, MINT, STRING, and/or I2D (see all 33)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD1Q157972, 3MINT-62013 I2D: score=3 
    PIGCQ925353, ENSP000002583244I2D: score=3 STRING: ENSP00000258324
    TSG101Q998163, ENSP000002519684I2D: score=1 STRING: ENSP00000251968
    PIGPP570543, ENSP000004200374I2D: score=1 STRING: ENSP00000420037
    PIGAP372873, ENSP000003698204I2D: score=3 STRING: ENSP00000369820
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS9729469
    GO:0006501C-terminal protein lipidation TAS--
    GO:0006506GPI anchor biosynthetic process ----
    GO:0016254preassembly of GPI anchor in ER membrane TAS--
    GO:0043687post-translational protein modification TAS--

    PIGQ for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PIGQ

    Selected HMDB Compounds for PIGQ (see all 898)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
    3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
    3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
    3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
    3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
    3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
    3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PIGQ gene (2 alternative transcripts): 
    NM_004204.3  NM_148920.2  

    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000293874 ENST00000409527 ENST00000409439 ENST00000422307 ENST00000321878(uc010bqw.3 uc002chn.3 uc002cho.3 uc010uui.2)
    ENST00000439574 ENST00000026218 ENST00000470411(uc002chm.3) ENST00000443147
    ENST00000544860 ENST00000537901 ENST00000420990 ENST00000480424 ENST00000540241
    ENST00000476438(uc002chp.3) ENST00000540548
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    Selected AceView cDNA sequences (see all 182):

    AW452437 BI770953 AI951411 BQ889806 CA313364 CD674991 T30146 AL039837 
    AU099270 CB105661 BC048340 BU738432 F28959 F37194 NM_004204 AI061227 
    CD368383 BM545447 BQ940705 BC032015 CD674376 BC006377 AU104954 BQ073528 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PIGQ    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                                                                    
    SP2:                                                                                    
    SP3:                                                                    -               
    SP4:                                                                                    


    ECgene alternative splicing isoforms for PIGQ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PIGQ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCTCCCAG
    PIGQ Expression
    About this image


    PIGQ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Perivenous Hepatocytes Liver Lobule
             Liver Lobule
     
     Eye (Sensory Organs)
             Lens
    PIGQ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIGQ Protein Expression
        Custom PCR Arrays for PIGQ
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGQ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PIGQ gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pigq1 , 5 phosphatidylinositol glycan anchor biosynthesis, class more1, 5 81.35(n)1
    83.65(a)1
      17 (13.01 cM)5
    147551  NM_011822.31  NP_035952.21 
     259264275 
    chicken
    (Gallus gallus)
    Aves PIGQ1 phosphatidylinositol glycan anchor biosynthesis, class more 71.84(n)
    71.9(a)
      770171  XM_001232059.3  XP_001232060.2 
    lizard
    (Anolis carolinensis)
    Reptilia PIGQ6
    phosphatidylinositol glycan anchor biosynthesis, c...
    67(a)
    1 ↔ 1
    GL344333.1(5343-41546)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pigq1 phosphatidylinositol glycan anchor biosynthesis, class more 66.01(n)
    67.38(a)
      100216058  NM_001142046.1  NP_001135518.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb3592 sbcb359 73.77(n)   321218  BC053210.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gpi13 GPI anchor biosynthesis 34(a)   14B18   --
    worm
    (Caenorhabditis elegans)
    Secernentea F01G4.51 F01G4.5 43.79(n)
    34.55(a)
      178019  NM_069685.3  NP_502086.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GPI1(YGR216C)4 Membrane protein involved in the synthesis of N-acetylglucosaminyl more   --   7(924462-922633) 853130  NP_011732.1 


    ENSEMBL Gene Tree for PIGQ (if available)
    TreeFam Gene Tree for PIGQ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PIGQ gene

    PIGQ for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PIGQ
    PGOHUM00000244039


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PIGQ (see all 1187)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1459050621,2
    C--538504(+) TCCCC-/TGTCGG 2 -- int10--------
    rs1995313091,2
    C--538566(+) GAGGGA/C/TCCCGG 2 -- int10--------
    rs1112995581,2
    C--538833(+) TCCCCG/TGTCGG 2 -- int11Minor allele frequency- T:0.50NA 2
    rs1161356321,2
    F--538902(+) CCTGTT/CGGTGA 2 -- int12Minor allele frequency- C:0.19WA EA 238
    rs1459256561,2
    C--538910(+) GAGGG-/TGCCCC 2 -- int10--------
    rs1439446161,2
    --538914(+) GGCCCC/TGGTCG 2 -- int10--------
    rs1488100911,2
    --538951(+) CGGTCA/GGTGAG 2 -- int10--------
    rs1440436621,2
    C--538964(+) GCCCCA/C/GGTCGG 2 -- int10--------
    rs1173957951,2
    F--539013(+) TCCCCG/TGTCGG 2 -- int11Minor allele frequency- T:0.19EA 120
    rs1485164581,2
    C--539026(+) AGGGTC/GCCCTG 2 -- int10--------

    HapMap Linkage Disequilibrium report for PIGQ (616995 - 634136 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PIGQ (see all 28):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2750209CNV Deletion23290073
    esv2750210CNV Deletion23290073
    esv1189330CNV Deletion17803354
    esv2750211CNV Deletion23290073
    esv2750208CNV Deletion23290073
    esv1003846CNV Deletion20482838
    esv2422427CNV Duplication17116639
    dgv2475n71CNV Loss21882294
    nsv904707CNV Loss21882294
    dgv2481n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605754    OMIM disorders: --

    3 diseases for PIGQ:    
    About MalaCards
    scrapie    hypertension    cerebritis


    PIGQ for disorders           About GeneDecksing

    Genetic Association Database (GAD): PIGQ
    Human Genome Epidemiology (HuGE) Navigator: PIGQ (2 documents)

    Export disorders for PIGQ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIGQ gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with PIGQ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants. (PubMed id 9729469)1, 2, 3, 9 Tiede A.... Schmidt R.E. (Biochem. J. 1998)
    2. The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1. (PubMed id 9463366)1, 2, 3 Watanabe R....Kinoshita T. (EMBO J. 1998)
    3. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. (PubMed id 10944123)1, 2, 9 Watanabe R.... Kinoshita T. (EMBO J. 2000)
    4. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    6. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (Nature 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (Hum. Mol. Genet. 2001)
    9. Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects. (PubMed id 22993228)1 Williams F.M....Spector T.D. (Ann. Rheum. Dis. 2013)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9091 HGNC: 14135 AceView: PIGQandFLJ36208 Ensembl:ENSG00000007541 euGenes: HUgn9091
    ECgene: PIGQ Kegg: 9091 H-InvDB: PIGQ

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PIGQ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PIGQ gene:
    Search GeneIP for patents involving PIGQ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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