Aliases for PIGO Gene
External Ids for PIGO Gene
Previous GeneCards Identifiers for PIGO Gene
This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This protein is involved in the transfer of ethanolaminephosphate (EtNP) to the third mannose in GPI. At least three alternatively spliced transcripts encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for PIGO Gene
PIGO (Phosphatidylinositol Glycan Anchor Biosynthesis, Class O) is a Protein Coding gene. Diseases associated with PIGO include hyperphosphatasia with mental retardation syndrome 2 and hyperphosphatasia-intellectual disability syndrome. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include transferase activity. An important paralog of this gene is PIGG.
UniProtKB/Swiss-Prot for PIGO Gene
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond (By similarity).