Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PIGO Gene

protein-coding   GIFtS: 59
GCID: GC09M035088

Phosphatidylinositol Glycan Anchor Biosynthesis, Class O

(Previous names: phosphatidylinositol glycan, class O)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phosphatidylinositol Glycan Anchor Biosynthesis, Class O1 2     RP11-182N22.42
Phosphatidylinositol-Glycan Biosynthesis Class O Protein2 3     GPI Ethanolamine Phosphate Transferase 32
Phosphatidylinositol Glycan, Class O1     EC 2.-.-.-3
HPMRS22     PIG-O3

External Ids:    HGNC: 232151   Entrez Gene: 847202   Ensembl: ENSG000001652827   OMIM: 6147305   UniProtKB: Q8TEQ83   

Export aliases for PIGO gene to outside databases

Previous GC identifers: GC09M035400 GC09M035258 GC00U912968 GC09M035079 GC09M035080 GC09M035081


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PIGO Gene:
This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The
GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found
on many blood cells and serves to anchor proteins to the cell surface. This protein is involved in the transfer
of ethanolaminephosphate (EtNP) to the third mannose in GPI. At least three alternatively spliced transcripts
encoding two distinct isoforms have been found for this gene. (provided by RefSeq, Jan 2011)

GeneCards Summary for PIGO Gene: 
PIGO (phosphatidylinositol glycan anchor biosynthesis, class O) is a protein-coding gene. Diseases associated with PIGO include hyperphosphatasia with mental retardation syndrome 2, and hyperphosphatasia with mental retardation syndrome, and among its related super-pathways are Post-translational modification: synthesis of GPI-anchored proteins and Post-translational protein modification. GO annotations related to this gene include transferase activity and molecular_function.

UniProtKB/Swiss-Prot: PIGO_HUMAN, Q8TEQ8
Function: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the
proteins by an amide bond (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008413.18  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PIGO gene promoter:
         CREB   USF-1   deltaCREB   NF-kappaB1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIGO promoter sequence
   Search SABiosciences Chromatin IP Primers for PIGO

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIGO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13.2

PIGO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIGO gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M035088:  view genomic region     (about GC identifiers)

Start:
35,088,685 bp from pter      End:
35,096,598 bp from pter
Size:
7,914 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PIGO_HUMAN, Q8TEQ8 (See protein sequence)
Recommended Name: GPI ethanolamine phosphate transferase 3  
Size: 1089 amino acids; 118699 Da
Subunit: Forms a complex with PIGF. PIGF is required to stabilize PIGO (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
Sequence caution: Sequence=AAC07985.1; Type=Erroneous gene model prediction; Sequence=AAH01030.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AAH13987.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=BAB84890.1; Type=Frameshift; Positions=Several;
Sequence=BAC03414.1; Type=Frameshift; Positions=Several; Sequence=CAD38806.1; Type=Frameshift; Positions=46;
Secondary accessions: B1AML3 Q6P154 Q6UX80 Q8TDS8 Q96CS9 Q9BVN9 Q9Y4B0
Alternative splicing: 2 isoforms:  Q8TEQ8-1   Q8TEQ8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PIGO: NX_Q8TEQ8

Explore proteomics data for PIGO at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TEQ8

  • PIGO Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PIGO Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001188413.1  NP_116023.2  NP_690577.2  

    ENSEMBL proteins: 
     ENSP00000298004   ENSP00000367880   ENSP00000339382   ENSP00000354678  
    Reactome Protein details: Q8TEQ8
    Human Recombinant Protein Products for PIGO: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PIGO
    GenScript Custom Purified and Recombinant Proteins Services for PIGO
    Novus Biologicals PIGO Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PIGO 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane ISS--
    GO:0016021integral to membrane IEA--

    PIGO for ontologies           About GeneDecksing



    PIGO Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PIGO
    GenScript Custom Superior Antibodies Services for PIGO
    Novus Biologicals PIGO Antibodies
    Abcam antibodies for PIGO
    Cloud-Clone Corp. Antibodies for PIGO 
    ThermoFisher Antibodies for PIGO
    LSBio Antibodies in human, mouse, rat for PIGO 

    Assay Products for PIGO: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PIGO
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PIGO
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PIGO 
    Cloud-Clone Corp. CLIAs for PIGO


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PIG: Phosphatidylinositol glycan anchor biosynthesis

    3 InterPro protein domains:
     IPR017849 Alkaline_Pase-like_a/b/a
     IPR002591 Phosphodiest/P_Trfase
     IPR017850 Alkaline_phosphatase_core

    Graphical View of Domain Structure for InterPro Entry Q8TEQ8

    ProtoNet protein and cluster: Q8TEQ8

    1 Blocks protein domain: IPB002591 Type I phosphodiesterase/nucleotide pyrophosphatase

    UniProtKB/Swiss-Prot: PIGO_HUMAN, Q8TEQ8
    Similarity: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily


    PIGO for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIGO_HUMAN, Q8TEQ8
    Function: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
    Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the
    proteins by an amide bond (By similarity)

         Enzyme Number (IUBMB): EC 2.-.-.-1

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003824catalytic activity ----
    GO:0005515protein binding ----
    GO:0008484sulfuric ester hydrolase activity ----
    GO:0016740transferase activity IEA--
         
    PIGO for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PIGO:
     Decreased viability of wild-ty  Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PIGO 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PIGO

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PIGO 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PIGO 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIGO
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate PIGO:
    hsa-miR-647 hsa-miR-3678-3p
    SwitchGear 3'UTR luciferase reporter plasmidPIGO 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PIGO
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIGO

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PIGO
    Sirion Biotech Customized adenovirus for overexpression of PIGO

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PIGO (see all 13)
    OriGene ORF clones in mouse, rat for PIGO
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PIGO (NM_152850)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIGO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIGO
    Sirion Biotech Customized lentivirus for stable overexpression of PIGO 
                         Customized lentivirus expression plasmids for stable overexpression of PIGO 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PIGO
    Search LifeMap BioReagents cell lines for PIGO
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGO


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PIGO About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Post-translational modification: synthesis of GPI-anchored proteins
    Post-translational modification: synthesis of GPI-anchored proteins0.79
    Synthesis of glycosylphosphatidylinositol (GPI)0.64
    Glycosylphosphatidylinositol(GPI)-anchor biosynthesis0.79
    2Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.35
    3Metabolism
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for PIGO
        Metabolism of proteins
    Post-translational modification: synthesis of GPI-anchored proteins
    Post-translational protein modification
    Synthesis of glycosylphosphatidylinositol (GPI)


    2         Kegg Pathways  (Kegg details for PIGO):
        Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: PIGO_HUMAN, Q8TEQ8
    Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis


    PIGO for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIGO

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/15 Interacting proteins for PIGO (Q8TEQ83 ENSP000003393824) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIGGQ5H8A43, ENSP000004152034I2D: score=1 STRING: ENSP00000415203
    PIGFQ073263, ENSP000002813824I2D: score=1 STRING: ENSP00000281382
    PIGNO954273, ENSP000003502634I2D: score=1 STRING: ENSP00000350263
    RPS20P608663I2D: score=5 
    DBNLQ9UJU63I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006501C-terminal protein lipidation TAS--
    GO:0006506GPI anchor biosynthetic process ISS--
    GO:0008152metabolic process ----
    GO:0016254preassembly of GPI anchor in ER membrane TAS--
    GO:0043687post-translational protein modification TAS--

    PIGO for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PIGO

    10/898 HMDB Compounds for PIGO (see all 898)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
    3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
    3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
    3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
    3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
    3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
    3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--

    Search CenterWatch for drugs/clinical trials and news about PIGO

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PIGO gene (3 alternative transcripts): 
    NM_001201484.1  NM_032634.3  NM_152850.3  

    Unigene Cluster for PIGO:

    Phosphatidylinositol glycan anchor biosynthesis, class O
    Hs.522099  [show with all ESTs]
    Unigene Representative Sequence: AL833956
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298004 ENST00000474436(uc003zwe.3 uc003zwd.3 uc003zwc.1)
    ENST00000378617 ENST00000465745(uc003zwg.2) ENST00000491687 ENST00000472208
    ENST00000492770 ENST00000341666 ENST00000361778(uc003zwf.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIGO
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate PIGO:
    hsa-miR-647 hsa-miR-3678-3p
    SwitchGear 3'UTR luciferase reporter plasmidPIGO 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PIGO
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIGO
    Clone
    Products:
         
    OriGene clones in human, mouse for PIGO (see all 13)
    OriGene ORF clones in mouse, rat for PIGO
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PIGO (NM_152850)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIGO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIGO
    Sirion Biotech Customized lentivirus for stable overexpression of PIGO 
                         Customized lentivirus expression plasmids for stable overexpression of PIGO 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PIGO
    OriGene qSTAR qPCR primer pairs in human, mouse for PIGO
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PIGO
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIGO
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIGO

    Additional mRNA sequence: 

    AL833956.1 AY358472.1 BC001030.2 BC013987.2 BC029271.1 BC036916.1 BC065282.1 

    9 DOTS entries:

    DT.97804013  DT.97844314  DT.91699743  DT.75116313  DT.91691151  DT.97818237  DT.100661504  DT.100661508 
    DT.91723836 

    24/135 AceView cDNA sequences (see all 135):

    BM847013 BM757134 BM756837 AK090433 AA582939 BI907424 AK074064 BE909527 
    BQ631574 BU633181 BI760735 AI569184 AI689809 BC065282 BM766758 NM_152850 
    BC013987 BQ649237 BC036916 BM723055 NM_032634 BE139632 AW469987 AY358472 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PIGO (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
    SP1:                                                                    -                                             
    SP2:                    -                                                                                             
    SP3:                                                                                                                  
    SP4:        -     -     -                                                                                             
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for PIGO

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PIGO expression in normal human tissues (normalized intensities)      PIGO embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCCAGGGG
    PIGO Expression
    About this image


    PIGO expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Primitive Streak (Early Embryonic Tissues)
             Notochord
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Kidney (Urinary System)
             renal vesicle e12.5   
     
     Cartilage (Muscoskeletal System)
             Intervertebral Disc Nucleus Pulposus Cells Lumbar Intervertebral Disc

    See PIGO Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PIGO

    SOURCE GeneReport for Unigene cluster: Hs.522099
        SABiosciences Custom PCR Arrays for PIGO
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PIGO
    OriGene qSTAR qPCR primer pairs in human, mouse for PIGO
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PIGO
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIGO
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIGO
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGO

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PIGO gene from 10/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pigo1 , 5 phosphatidylinositol glycan anchor biosynthesis, class more1, 5 84.85(n)1
    86.41(a)1
      4 (22.98 cM)5
    567031  NM_020035.21  NP_064419.21 
     430176355 
    chicken
    (Gallus gallus)
    Aves PIGO6
    Uncharacterized protein
    57(a)
    1 ↔ 1
    Z(8437661-8449236)
    lizard
    (Anolis carolinensis)
    Reptilia PIGO6
    Uncharacterized protein
    50(a)
    1 ↔ 1
    GL343804.1(103212-119255)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.54642 Transcribed sequence with weak similarity to protein more 74.78(n)    BQ522572.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.151742 Transcribed sequence with weak similarity to protein more 77.42(n)    57095222 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG122631 CG12263 44.17(n)
    34.18(a)
      37118  NM_137488.2  NP_611332.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C27A12.91 Protein C27A12.9 46.42(n)
    39.85(a)
      172285  NM_059349.3  NP_491750.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GPI13(YLL031C)4 ER membrane localized phosphoryltransferase that adds more   --   12(80205-77152) 850628  NP_013069.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G172501 alkaline-phosphatase-like protein 47.3(n)
    39.37(a)
      831589  NM_121731.5  NP_197227.4 
    rice
    (Oryza sativa)
    Liliopsida Os.74532 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 76.88(n)    AK068119.1 


    ENSEMBL Gene Tree for PIGO (if available)
    TreeFam Gene Tree for PIGO (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/300 SNPs in PIGO are shown (see all 300)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363324
    A colorectal cancer sample4--see VAR_0363322 L M mis40--------
    VAR_0688094
    Hyperphosphatasia with mental retardation syndrome 2 (HPMRS2)4--see VAR_0688092 L F mis40--------
    rs1507178691,2
    --35056591(+) ACACAA/GTTTTG 3 -- ds50010--------
    rs1925011071,2
    --35056700(+) GCTTCC/TACAGA 3 -- ds50010--------
    rs1137855371,2
    F--35056893(+) AGCGGT/AGGGAT 3 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs792769331,2
    C,F--35057223(+) TAGGTG/CCAAGT 3 -- ut311Minor allele frequency- C:0.12WA 118
    rs1832281011,2
    --35057255(+) TTCCAA/CTTCGG 3 -- ut310--------
    rs1440781701,2
    --35057361(+) GTCAGC/TGGCCC 3 -- ut310--------
    rs5567661,2
    C,F,H--35057449(+) TTCTCC/AAGCAC 3 -- ut3125Minor allele frequency- A:0.02MN NA NS EA WA CSA EU 2970
    rs1473167711,2
    C,F--35057597(+) AATGAA/GGCCCA 6 L F mis12Minor allele frequency- G:0.00NA EU 5845

    HapMap Linkage Disequilibrium report for PIGO (35088685 - 35096598 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PIGO:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv893044CNV Loss21882294
    nsv893043CNV Gain21882294


    Human Gene Mutation Database (HGMD): PIGO
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PIGO
    DNA2.0 Custom Variant and Variant Library Synthesis for PIGO

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614730    OMIM disorders: --

    UniProtKB/Swiss-Prot: PIGO_HUMAN, Q8TEQ8
  • Hyperphosphatasia with mental retardation syndrome 2 (HPMRS2) [MIM:614749]: An autosomal recessive form
    of intellectual disability characterized by facial dysmorphism, brachytelephalangy, and persistent elevated serum
    alkaline phosphatase (hyperphosphatasia). Some patients may have additional features, such as cardiac septal
    defects or seizures. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 8 diseases for PIGO:    About MalaCards
    hyperphosphatasia with mental retardation syndrome 2    hyperphosphatasia with mental retardation syndrome    plasmodium falciparum malaria    gingival overgrowth
    gingivitis    malaria    intellectual disability    mental retardation


    PIGO for disorders           About GeneDecksing

    Genetic Association Database (GAD): PIGO
    Human Genome Epidemiology (HuGE) Navigator: PIGO (4 documents)

    Export disorders for PIGO gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PIGO gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with PIGO)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in PIGO, a member of the GPI-anchor-synthesis pathway, cause hyperphosphatasia with mental retardation. (PubMed id 22683086)1, 2 Krawitz P.M....Horn D. (2012)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (2002)
    8. Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol. (PubMed id 10781593)1, 3 Hong Y....Kinoshita T. (2000)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84720 HGNC: 23215 AceView: PIGO Ensembl:ENSG00000165282 euGenes: HUgn84720
    ECgene: PIGO Kegg: 84720 H-InvDB: PIGO

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PIGO Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PIGO gene:
    Search GeneIP for patents involving PIGO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PIGO  
     OriGene qPCR primer pairs and template standards for PIGO   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PIGO  
     OriGene qSTAR qPCR primer pairs in human, mouse for PIGO   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PIGO   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PIGO   OriGene Custom Protein Services for PIGO  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PIGO
     QIAGEN SeqTarget long-range PCR primers for resequencing PIGO
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIGO
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIGO
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIGO
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIGO
     GenScript Custom Purified and Recombinant Proteins Services for PIGO GenScript cDNA clones with any tag delivered in your preferred vector for PIGO
     GenScript Custom Assay Services for PIGO GenScript Custom Superior Antibodies Services for PIGO
     GenScript Custom overexpressing Cell Line Services for PIGO CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PIGO promoter
     Search Chromatin IP Primers for PIGO
     RT2 qPCR Primer Assay in human, mouse, rat PIGO
     GNC Network for PIGO
     SABiosciences Custom PCR Arrays for PIGO
     Search Tocris compounds for PIGO
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PIGO antibodies
     PIGO proteins
     Antibodies for PIGO
     See all of Abcam's Antibodies, Kits and Proteins for PIGO
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for PIGO
     Antibodies for PIGO
     ELISAs for PIGO
     CLIAs for PIGO
     Search LifeMap BioReagents cell lines for PIGO
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGO
     SwitchGear 3'UTR luciferase reporter plasmids for PIGO
     SwitchGear Promoter luciferase reporter plasmids for PIGO
     ThermoFisher Antibodies for PIGO
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIGO
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PIGO
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PIGO
    Customized:
     lentivirus for stable overexpression of PIGO
     lentivirus expression plasmids for stable overexpression of PIGO
     adenovirus for overexpression of PIGO
     LSBio Antibodies in human, mouse, rat for PIGO
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PIGO gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4