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Aliases for PIGM Gene

Aliases for PIGM Gene

  • Phosphatidylinositol Glycan Anchor Biosynthesis, Class M 2 3
  • Phosphatidylinositol-Glycan Biosynthesis Class M Protein 3 4
  • Dol-P-Man Dependent GPI Mannosyltransferase 2 3
  • DPM:GlcN-(Acyl-)PI Mannosyltransferase 2 3
  • GPI Mannosyltransferase 1 2 3
  • GPI Mannosyltransferase I 3 4
  • GPI-MT-I 3 4
  • Phosphatidylinositol Glycan, Class M 2
  • PIG-M Mannosyltransferase 3
  • EC 2.4.1.- 4
  • EC 2.4.1 63
  • PIG-M 4

External Ids for PIGM Gene

Previous GeneCards Identifiers for PIGM Gene

  • GC01M157791
  • GC01M155731
  • GC01M156777
  • GC01M157216
  • GC01M156812
  • GC01M158261
  • GC01M131354

Summaries for PIGM Gene

Entrez Gene Summary for PIGM Gene

  • This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]

GeneCards Summary for PIGM Gene

PIGM (Phosphatidylinositol Glycan Anchor Biosynthesis, Class M) is a Protein Coding gene. Diseases associated with PIGM include glycosylphosphatidylinositol deficiency and hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include mannosyltransferase activity.

UniProtKB/Swiss-Prot for PIGM Gene

  • Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIGM Gene

Genomics for PIGM Gene

Regulatory Elements for PIGM Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PIGM Gene

160,027,672 bp from pter
160,031,993 bp from pter
4,322 bases
Minus strand

Genomic View for PIGM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIGM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIGM Gene

Proteins for PIGM Gene

  • Protein details for PIGM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GPI mannosyltransferase 1
    Protein Accession:
    Secondary Accessions:

    Protein attributes for PIGM Gene

    423 amino acids
    Molecular mass:
    49460 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PIGM Gene

Proteomics data for PIGM Gene at MOPED

Post-translational modifications for PIGM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIGM Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PIGM Gene

Protein Domains for PIGM Gene


Suggested Antigen Peptide Sequences for PIGM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PIGM family.
  • Belongs to the PIGM family.
genes like me logo Genes that share domains with PIGM: view

Function for PIGM Gene

Molecular function for PIGM Gene

UniProtKB/Swiss-Prot Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.

Enzyme Numbers (IUBMB) for PIGM Gene

Gene Ontology (GO) - Molecular Function for PIGM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000030 mannosyltransferase activity IEA --
GO:0016758 transferase activity, transferring hexosyl groups --
genes like me logo Genes that share ontologies with PIGM: view

Animal Model Products

miRNA for PIGM Gene

miRTarBase miRNAs that target PIGM

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for PIGM Gene

Localization for PIGM Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIGM Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for PIGM Gene COMPARTMENTS Subcellular localization image for PIGM gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for PIGM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PIGM: view

Pathways for PIGM Gene

genes like me logo Genes that share pathways with PIGM: view

UniProtKB/Swiss-Prot Q9H3S5-PIGM_HUMAN

  • Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis

Interacting Proteins for PIGM Gene

Gene Ontology (GO) - Biological Process for PIGM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0006506 GPI anchor biosynthetic process --
GO:0016254 preassembly of GPI anchor in ER membrane TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with PIGM: view

Drugs for PIGM Gene

(897) HMDB Compounds for PIGM Gene

Compound Synonyms Cas Number PubMed IDs
  • (2S)-2-amino-1-hydroxyoctadecan-3-one
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
genes like me logo Genes that share compounds with PIGM: view

Transcripts for PIGM Gene

mRNA/cDNA for PIGM Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(125) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PIGM Gene

Phosphatidylinositol glycan anchor biosynthesis, class M:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIGM Gene

No ASD Table

Relevant External Links for PIGM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PIGM Gene

mRNA expression in normal human tissues for PIGM Gene

Protein differential expression in normal tissues for PIGM Gene

This gene is overexpressed in Retina (22.3), Fetal Brain (11.4), Ovary (9.3), Pancreas (9.1), and CD4 Tcells (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIGM Gene

SOURCE GeneReport for Unigene cluster for PIGM Gene Hs.552810

genes like me logo Genes that share expressions with PIGM: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for PIGM Gene

Orthologs for PIGM Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PIGM Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PIGM 35
  • 87.23 (n)
  • 90.07 (a)
  • 90 (a)
(Canis familiaris)
Mammalia PIGM 35
  • 72.99 (n)
  • 76.64 (a)
  • 76 (a)
(Mus musculus)
Mammalia Pigm 35
  • 85.66 (n)
  • 89.83 (a)
Pigm 16
Pigm 36
  • 90 (a)
(Pan troglodytes)
Mammalia PIGM 35
  • 99.45 (n)
  • 99.76 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Pigm 35
  • 86.6 (n)
  • 91.02 (a)
(Monodelphis domestica)
Mammalia PIGM 36
  • 72 (a)
(Gallus gallus)
Aves PIGM 35
  • 65.58 (n)
  • 62.72 (a)
  • 60 (a)
(Anolis carolinensis)
Reptilia PIGM 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pigm 35
  • 63.64 (n)
  • 63.9 (a)
Str.17051 35
(Danio rerio)
Actinopterygii pigm 35
  • 57.94 (n)
  • 57.94 (a)
zgc64177 35
pigm 36
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010434 35
  • 48.38 (n)
  • 41.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9865 35
  • 48.63 (n)
  • 41.64 (a)
CG9865 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea B0491.1 35
  • 51.2 (n)
  • 44.53 (a)
B0491.1 36
  • 40 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR034W 35
  • 52.68 (n)
  • 44.96 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D09647g 35
  • 48.38 (n)
  • 42.97 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPI14 35
  • 50.13 (n)
  • 40.99 (a)
GPI14 36
  • 38 (a)
GPI14 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PNT1 35
  • 47.46 (n)
  • 42.89 (a)
(Oryza sativa)
Liliopsida Os03g0670200 35
  • 50.26 (n)
  • 42.75 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06057 35
  • 49.74 (n)
  • 44.74 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gpi14 35
  • 46.16 (n)
  • 42.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
Species with no ortholog for PIGM:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIGM Gene

Gene Tree for PIGM (if available)
Gene Tree for PIGM (if available)

Paralogs for PIGM Gene

No data available for Paralogs for PIGM Gene

Variants for PIGM Gene

Sequence variations from dbSNP and Humsavar for PIGM Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1319086 -- 160,027,214(-) TGAAT(A/G)GAAAA downstream-variant-500B
rs1934085 -- 160,027,573(+) ATCAT(A/C)CCTCT downstream-variant-500B
rs2275404 -- 160,028,650(+) TTTTT(A/G)TCTTT utr-variant-3-prime
rs2789437 -- 160,033,862(+) TAGTG(A/G)CAGTG upstream-variant-2KB
rs2789438 -- 160,033,991(+) CATCT(G/T)GATAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PIGM Gene

Variant ID Type Subtype PubMed ID
esv2669935 CNV Deletion 23128226

Relevant External Links for PIGM Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIGM Gene

Disorders for PIGM Gene

(1) OMIM Diseases for PIGM Gene (610273)


  • Glycosylphosphatidylinositol deficiency (GPID) [MIM:610293]: Autosomal recessive trait that results in a propensity to venous thrombosis and seizures. Deficiency is due to a point mutation in the regulatory sequences of PIGM that disrupts binding of the transcription factor SP1 to its cognate promoter motif, leading to a strong reduction of expression. {ECO:0000269 PubMed:16767100}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with PIGM: view

No data available for University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for PIGM Gene

Publications for PIGM Gene

  1. PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER. (PMID: 11226175) Maeda Y. … Kinoshita T. (EMBO J. 2001) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Hypomorphic promoter mutation in PIGM causes inherited glycosylphosphatidylinositol deficiency. (PMID: 16767100) Almeida A.M. … Karadimitris A. (Nat. Med. 2006) 3 4

Products for PIGM Gene

Sources for PIGM Gene

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