Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PIGK Gene

protein-coding   GIFtS: 64
GCID: GC01M077554

Phosphatidylinositol Glycan Anchor Biosynthesis, Class K

(Previous names: phosphatidylinositol glycan, class K)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Phosphatidylinositol Glycan Anchor Biosynthesis, Class K1 2     GPI8 Homolog2 3
GPI82 3 5     GPI-Anchor Transamidase2
Phosphatidylinositol Glycan, Class K1 2     EC 3.-.-.-3
GPI Transamidase Subunit1 2     GPI Transamidase3
Phosphatidylinositol-Glycan Biosynthesis Class K Protein2 3     hGPI83
PIG-K2 3     

External Ids:    HGNC: 89651   Entrez Gene: 100262   Ensembl: ENSG000001428927   OMIM: 6050875   UniProtKB: Q926433   

Export aliases for PIGK gene to outside databases

Previous GC identifers: GC01M077684 GC01M076501 GC01M076962 GC01M076979 GC01M076977 GC01M077269 GC01M075685


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PIGK Gene:
This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol
(GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins
to the cell surface. This protein is a member of the multisubunit enzyme, GPI transamidase and is thought to be
its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the
transfer of fully assembled GPI units to proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for PIGK Gene:
PIGK (phosphatidylinositol glycan anchor biosynthesis, class K) is a protein-coding gene. GO annotations related to this gene include cysteine-type endopeptidase activity and GPI anchor binding. An important paralog of this gene is LGMN.

UniProtKB/Swiss-Prot: GPI8_HUMAN, Q92643
Function: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment
signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a
carbonyl intermediate with the substrate protein

Gene Wiki entry for PIGK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the PIGK gene promoter:
         HFH-3   Spz1   Sp1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   YY1   RORalpha1   FOXI1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIGK promoter sequence
   Search Chromatin IP Primers for PIGK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIGK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

PIGK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIGK gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M077554:  view genomic region     (about GC identifiers)

Start:
77,554,666 bp from pter      End:
77,685,132 bp from pter
Size:
130,467 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GPI8_HUMAN, Q92643 (See protein sequence)
Recommended Name: GPI-anchor transamidase precursor  
Size: 395 amino acids; 45252 Da
Subunit: Forms a complex with PIGT, PIGS, PIGU and GAA1
Secondary accessions: B2R7K3 O14822 Q5TG77

Explore the universe of human proteins at neXtProt for PIGK: NX_Q92643

Explore proteomics data for PIGK at MOPED

Post-translational modifications: 

  • The disulfide bond between PIGK/GPI8 and PIGT is important for normal enzyme activity1
  • Ubiquitination2 at Lys296
  • Modification sites at PhosphoSitePlus

  • See PIGK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005473.1  
    ENSEMBL proteins: 
     ENSP00000359848   ENSP00000388854   ENSP00000474518   ENSP00000352041   ENSP00000359849  
    Reactome Protein details: Q92643

    PIGK Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PIGK
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PIGK
    GenScript Custom Purified and Recombinant Proteins Services for PIGK
    Novus Biologicals PIGK Protein
    Novus Biologicals PIGK Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PIGK

     
    Search eBioscience for Proteins for PIGK 

     
    antibodies-online proteins for PIGK (2 products) 

     
    antibodies-online peptides for PIGK

    PIGK Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PIGK
    Novus Biologicals PIGK Antibodies
    Abcam antibodies for PIGK
    Cloud-Clone Corp. Antibodies for PIGK
    ThermoFisher Antibodies for PIGK
    antibodies-online antibodies for PIGK (30 products) 

    PIGK Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PIGK
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PIGK
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PIGK
    Cloud-Clone Corp. CLIAs for PIGK
    Search eBioscience for ELISAs for PIGK 
    antibodies-online kits for PIGK (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PIG: Phosphatidylinositol glycan anchor biosynthesis

    2 InterPro protein domains:
     IPR001096 Peptidase_C13
     IPR028361 GPI_transamidase

    Graphical View of Domain Structure for InterPro Entry Q92643

    ProtoNet protein and cluster: Q92643

    1 Blocks protein domain: IPB001096 Hemoglobinase (C13) cysteine protease signature

    UniProtKB/Swiss-Prot: GPI8_HUMAN, Q92643
    Similarity: Belongs to the peptidase C13 family


    Find genes that share domains with PIGK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPI8_HUMAN, Q92643
    Function: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment
    signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a
    carbonyl intermediate with the substrate protein

         Genatlas biochemistry entry for PIGK:
    phosphatidylinositol glycan,class K,mutated in K562 cell line,yeast GPI8 homolog,association with GPAA1 for GPI
    anchor attachment

         Enzyme Number (IUBMB): EC 3.-.-.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003756protein disulfide isomerase activity TAS12582175
    GO:0003923GPI-anchor transamidase activity TAS--
    GO:0004197cysteine-type endopeptidase activity IEA--
    GO:0005515protein binding IPI10793132
    GO:0034235contributes to GPI anchor binding TAS10793132
         
    Find genes that share ontologies with PIGK           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PIGK:
     Decreased p24 protein expressi 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PIGK

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat PIGK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PIGK (see all 29):
    hsa-miR-320a hsa-miR-607 hsa-miR-640 hsa-miR-1197 hsa-miR-1260b hsa-miR-765 hsa-miR-938 hsa-miR-16-1*
    SwitchGear 3'UTR luciferase reporter plasmidPIGK 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PIGK
    Predesigned siRNA for gene silencing in human, mouse, rat PIGK

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PIGK

    Clone
    Products:
         
    OriGene clones in human, mouse for PIGK (see all 9)
    OriGene ORF clones in mouse, rat for PIGK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PIGK (NM_005482)
    Sino Biological Human cDNA Clone for PIGK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIGK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIGK

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PIGK
    Browse ESI BIO Cell Lines and PureStem Progenitors for PIGK 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GPI8_HUMAN, Q92643: Endoplasmic reticulum membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    lysosome2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0030176integral component of endoplasmic reticulum membrane NAS11483512
    GO:0042765GPI-anchor transamidase complex IMP10793132

    Find genes that share ontologies with PIGK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PIGK About    
    See pathways by source

    SuperPathContained pathways About
    1Post-translational modification- synthesis of GPI-anchored proteins
    Post-translational modification- synthesis of GPI-anchored proteins0.76
    Attachment of GPI anchor to uPAR0.00
    Glycosylphosphatidylinositol(GPI)-anchor biosynthesis0.76
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30
    3Metabolism
    Metabolic pathways0.38


    Find genes that share SuperPaths with PIGK           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for PIGK
        Attachment of GPI anchor to uPAR


    2 Kegg Pathways  (Kegg details for PIGK):
        Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: GPI8_HUMAN, Q92643
    Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PIGK
    Interactions:

        GeneGlobe Interaction Network for PIGK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PIGK (Q926432, 3 ENSP000003598484) via UniProtKB, MINT, STRING, and/or I2D (see all 85)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALPPP051872, 3, ENSP000003758814MINT-8216721 I2D: score=3 STRING: ENSP00000375881
    ENSG00000206288Q925043I2D: score=1 
    ENSG00000224399Q925043I2D: score=1 
    ENSG00000226614Q925043I2D: score=1 
    ENSG00000227402Q925043I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS12582175
    GO:0006501C-terminal protein lipidation TAS--
    GO:0006508proteolysis ----
    GO:0016255attachment of GPI anchor to protein TAS11483512
    GO:0043687post-translational protein modification TAS--

    Find genes that share ontologies with PIGK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PIGK (GPI8)

    Selected HMDB Compounds for PIGK (see all 519)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
    3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
    3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
    3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
    3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
    3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
    3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--

    1 Novoseek inferred chemical compound relationship for PIGK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipid 6.54 1 12802054 (1)



    Find genes that share compounds with PIGK           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PIGK gene: 
    NM_005482.2  

    Unigene Cluster for PIGK:

    Phosphatidylinositol glycan anchor biosynthesis, class K
    Hs.178305  [show with all ESTs]
    Unigene Representative Sequence: NM_005482
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370812(uc001dhk.3 uc010orj.2) ENST00000445065(uc009wbx.3)
    ENST00000487906 ENST00000359130(uc001dhl.1) ENST00000478391 ENST00000370813

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PIGK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PIGK (see all 29):
    hsa-miR-320a hsa-miR-607 hsa-miR-640 hsa-miR-1197 hsa-miR-1260b hsa-miR-765 hsa-miR-938 hsa-miR-16-1*
    SwitchGear 3'UTR luciferase reporter plasmidPIGK 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PIGK
    Predesigned siRNA for gene silencing in human, mouse, rat PIGK
    Clone
    Products:
         
    OriGene clones in human, mouse for PIGK (see all 9)
    OriGene ORF clones in mouse, rat for PIGK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PIGK (NM_005482)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIGK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIGK
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PIGK
    OriGene qSTAR qPCR primer pairs in human, mouse for PIGK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PIGK
      QuantiTect SYBR Green Assays in human, mouse, rat PIGK
      QuantiFast Probe-based Assays in human, mouse, rat PIGK

    Additional mRNA sequence: 

    AF022913.1 AK055071.1 AK304340.1 AK313015.1 BC020737.1 BX648473.1 Y07596.1 

    15 DOTS entries:

    DT.212890  DT.412841  DT.100768228  DT.100028580  DT.121365816  DT.100776627  DT.100748896  DT.95374692 
    DT.95374694  DT.121365796  DT.121365811  DT.40313624  DT.95374693  DT.91774023  DT.91774034 

    Selected AceView cDNA sequences (see all 230):

    AW612942 F12669 AA464095 BM741888 AA428977 BU632643 AI123406 BU629350 
    AI539700 BU742217 CB156139 F10280 BC020737 BM693241 AW628276 AA449378 
    AK055071 AA994078 AI245742 AI983193 CR614831 CR594196 AI559559 BG778094 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PIGK    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
    SP1:                                                              -                     
    SP2:                                                                                    
    SP3:              -     -     -                                   -                     


    ECgene alternative splicing isoforms for PIGK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PIGK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATCCTGCA
    PIGK Expression
    About this image


    PIGK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Eye (Sensory Organs)
             Lens
    PIGK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIGK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.178305
        Custom PCR Arrays for PIGK
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PIGK
    OriGene qSTAR qPCR primer pairs in human, mouse for PIGK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PIGK
    QuantiTect SYBR Green Assays in human, mouse, rat PIGK
    QuantiFast Probe-based Assays in human, mouse, rat PIGK
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PIGK gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pigk1 , 5 phosphatidylinositol glycan anchor biosynthesis, class K less1, 5 83.8(n)1
    91.39(a)1
      3 (77.16 cM)5
    3297771  NM_025662.51  NP_079938.11 
     1527141005 
    chicken
    (Gallus gallus)
    Aves PIGK1 phosphatidylinositol glycan anchor biosynthesis, class K less 80.44(n)
    87.24(a)
      424556  NM_001031278.1  NP_001026449.1 
    lizard
    (Anolis carolinensis)
    Reptilia PIGK6
    phosphatidylinositol glycan anchor biosynthesis, c...
    70(a)
    1 ↔ 1
    AAWZ02038094(251-5387)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.67462 Xenopus laevis transcribed sequence with weak similarity to protein spQ99538 (H.sapiens) LEGU_HUMAN Legumain precursor (Asparaginyl endopeptidase) less 80(n)    BX846807.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pigk1 phosphatidylinositol glycan, class K 70.91(n)
    81.3(a)
      415239  NM_001002149.1  NP_001002149.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta EG:133E12.33
    CG44061
    GPI-anchor transamidase3
    CG44061
    62(a)3
    60.15(n)1
    62.82(a)1
      2C13
    311631  NM_130612.41  NP_569968.21 
    worm
    (Caenorhabditis elegans)
    Secernentea T05E11.63
    hpo-41
    haemoglobinase like3
    hpo-41
    55(a)3
    57.81(n)1
    54.1(a)1
      IV(11108824-11110243)3
    1881311  NM_069675.21  NP_502076.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GPI8(YDR331W)4
    GPI81
    ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog less4
    GPI81
    61.25(n)1
    60.15(a)1
      4(1129588-1130823)4
    8519311, 4  NP_010618.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G087501 AT1G08750 58.49(n)
    54.4(a)
      837397  NM_179285.1  NP_849616.1 
    rice
    (Oryza sativa)
    Liliopsida Os.242852 Oryza sativa (japonica cultivar-group) cDNA cloneJ023126A08, full insert sequence less 75.55(n)    AK072526.1 


    ENSEMBL Gene Tree for PIGK (if available)
    TreeFam Gene Tree for PIGK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PIGK gene
    LGMN2  

    Find genes that share paralogs with PIGK           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PIGK (see all 2411)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1832628681,2
    --77554206(+) CGGAGG/TTTCAC 1 -- ds50010--------
    rs1886182781,2
    --77554403(+) CCATGC/GCCAGC 1 -- ds50010--------
    rs111622691,2
    C,F,H--77554453(+) CCTAAG/AAAAGT 1 -- ds50019Minor allele frequency- A:0.25NS EA NA WA 778
    rs1997151,2
    C,F,O,A--77554542(+) GGGTCG/ATATCA 1 -- ds500115Minor allele frequency- A:0.49NA WA CSA EA 516
    rs1919449441,2
    --77554549(+) ATCATA/GTGATT 1 -- ds50010--------
    rs170998821,2
    C,F,H--77554641(+) TGCAGG/ATGACA 1 -- ds500120Minor allele frequency- A:0.07NA NS EA CSA WA 2377
    rs760449751,2
    C--77554647(+) TGACAA/CAAGAA 1 -- ds50010--------
    rs170998851,2
    C,F,H--77554775(+) TTCACA/GGCACA 1 -- ut3119Minor allele frequency- G:0.07NA NS EA WA 2382
    rs1157283011,2
    C--77555034(+) TCATTG/TTTTTA 1 -- ut310--------
    rs1833193081,2
    --77555058(+) TGGTAA/TGTTTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PIGK (77554666 - 77685132 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PIGK:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv271271CNV Insertion20981092
    esv2500895CNV Insertion19546169
    esv273566CNV Insertion20981092
    esv271361CNV Insertion20981092
    esv272308CNV Insertion20981092
    nsv525188CNV Loss19592680
    nsv520629CNV Loss19592680
    nsv830292CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PIGK
    DNA2.0 Custom Variant and Variant Library Synthesis for PIGK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605087    OMIM disorders: --


    Find genes that share disorders with PIGK           About GenesLikeMe

    Genetic Association Database (GAD): PIGK
    Human Genome Epidemiology (HuGE) Navigator: PIGK (1 document)

    Export disorders for PIGK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PIGK gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with PIGK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase. (PubMed id 9356492)1, 2, 3, 9 Yu J.... Medof M.E. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge. (PubMed id 12582175)1, 2, 9 Ohishi K.... Kinoshita T. (J. Biol. Chem. 2003)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8. (PubMed id 11483512)1, 2 Ohishi K.... Kinoshita T. (EMBO J. 2001)
    7. Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins. (PubMed id 10793132)1, 2 Ohishi K.... Kinoshita T. (Mol. Biol. Cell 2000)
    8. Yeast Gpi8p is essential for GPI anchor attachment onto proteins. (PubMed id 8978684)1, 2 Benghezal M.... Conzelmann A. (EMBO J. 1996)
    9. Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. (PubMed id 12802054)1, 9 Hong Y.... Kinoshita T. (Mol. Biol. Cell 2003)
    10. Proprotein interaction with the GPI transamidase. (PubMed id 12616539)1, 9 Chen R....Medof M.E. (J. Cell. Biochem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10026 HGNC: 8965 AceView: PIGK Ensembl:ENSG00000142892 euGenes: HUgn10026
    ECgene: PIGK Kegg: 10026 H-InvDB: PIGK

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PIGK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PIGK gene:
    Search GeneIP for patents involving PIGK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PIGK  
     OriGene qPCR primer pairs and template standards for PIGK   OriGene Protein Over-expression Lysate for PIGK  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PIGK  
     OriGene qSTAR qPCR primer pairs in human, mouse for PIGK   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PIGK   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PIGK   OriGene Custom Protein Services for PIGK  

     
     
     Block miRNA regulation of human, mouse, rat PIGK using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PIGK
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIGK Predesigned siRNA for gene silencing in human, mouse, rat PIGK
     QuantiFast Probe-based Assays in human, mouse, rat PIGK QuantiTect SYBR Green Assays in human, mouse, rat PIGK
     Custom PCR Arrays for PIGK Search Chromatin IP Primers for PIGK
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PIGK  GeneGlobe Interaction Network for PIGK
     Regulatory tfbs in PIGK promoter
     GenScript Custom Purified and Recombinant Proteins Services for PIGK GenScript cDNA clones with any tag delivered in your preferred vector for PIGK
     GenScript Custom Assay Services for PIGK GenScript Custom overexpressing Cell Line Services for PIGK
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PIGK (GPI8)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for PIGK
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PIGK antibodies
     PIGK proteins
     PIGK lysates
     Antibodies for PIGK
     See all of Abcam's Antibodies, Kits and Proteins for PIGK
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PIGK
     Antibodies for PIGK
     ELISAs for PIGK
     CLIAs for PIGK



     Browse ESI BIO Cell Lines and PureStem Progenitors for PIGK
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGK
     SwitchGear 3'UTR luciferase reporter plasmids for PIGK
     SwitchGear Promoter luciferase reporter plasmids for PIGK
     ThermoFisher Antibodies for PIGK
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIGK
     Browse compounds at ApexBio
     Search Addgene for plasmids for PIGK
      Search eBioscience for proteins for PIGK
      Search eBioscience for elisas for PIGK
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for PIGK
     antibodies-online antibodies for PIGK (30 products)
     antibodies-online kits for PIGK (8 products)
     antibodies-online peptides for PIGK
     antibodies-online proteins for PIGK (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PIGK gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4