Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PIGK Gene

protein-coding   GIFtS: 62
GCID: GC01M077554

phosphatidylinositol glycan anchor biosynthesis, class K

(Previous names: phosphatidylinositol glycan, class K )
 Explore 5 diseases affiliated with
PIGK via our new
 Human Malady Compendium 
Biological research products
for PIGK
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Phosphatidylinositol Glycan Anchor Biosynthesis, Class K1 2     GPI8 Homolog2 3
GPI81 2 3 5     GPI Transamidase Subunit2
Phosphatidylinositol Glycan, Class K1 2     GPI-Anchor Transamidase2
HGPI81     EC 3.-.-.-3
Phosphatidylinositol-Glycan Biosynthesis Class K Protein2 3     GPI Transamidase3
PIG-K2 3     

External Ids:    HGNC: 89651   Entrez Gene: 100262   Ensembl: ENSG000001428927   OMIM: 6050875   UniProtKB: Q926433   

Export aliases for PIGK gene to outside databases

Previous GC identifers: GC01M077684 GC01M076501 GC01M076962 GC01M076979 GC01M076977 GC01M077269 GC01M075685


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PIGK:
This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol
(GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to
the cell surface. This protein is a member of the multisubunit enzyme, GPI transamidase and is thought to be its
enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer
of fully assembled GPI units to proteins. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GPI8_HUMAN, Q92643
Function: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment
signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl
intermediate with the substrate protein

Gene Wiki entry for PIGK


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PIGK gene promoter:
         HFH-3   Spz1   Sp1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   YY1   RORalpha1   FOXI1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIGK promoter sequence
   Search SABiosciences Chromatin IP Primers for PIGK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIGK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

PIGK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIGK gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M077554:  view genomic region     (about GC identifiers)

Start:
77,554,666 bp from pter      End:
77,685,132 bp from pter
Size:
130,467 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GPI8_HUMAN, Q92643 (See protein sequence)
Recommended Name: GPI-anchor transamidase precursor  
Size: 395 amino acids; 45252 Da
Subunit: Forms a complex with PIGT, PIGS, PIGU and GAA1
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein
Secondary accessions: B2R7K3 O14822 Q5TG77

Explore the universe of human proteins at neXtProt for PIGK: NX_Q92643

Post-translational modifications:

  • The disulfide bond between PIGK/GPI8 and PIGT is important for normal enzyme activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92643

  • PIGK Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005473.1  
    ENSEMBL proteins: 
     ENSP00000359848   ENSP00000388854   ENSP00000352041   ENSP00000359849  
    Reactome Protein details: Q92643
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: PIGK
    OriGene Custom Protein Services for PIGK 
    GenScript Custom Purified and Recombinant Proteins Services for PIGK
    Novus Biologicals PIGK Protein
    Novus Biologicals PIGK Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PIGK

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0030176integral to endoplasmic reticulum membrane NAS11483512
    GO:0042765GPI-anchor transamidase complex IMP10793132


    PIGK for ontologies           About GeneDecksing



    PIGK Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PIGK 
    GenScript Custom Superior Antibodies Services for PIGK
    Novus Biologicals PIGK Antibodies
    Abcam antibodies for PIGK 
    Uscn Antibodies for PIGK
    ThermoFisher Antibodies for PIGK

    Assay Products for PIGK: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PIGK
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PIGK


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PIGK for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001096 Peptidase_C13

    Graphical View of Domain Structure for InterPro Entry Q92643

    ProtoNet protein and cluster: Q92643

    1 Blocks protein family: IPB001096 Hemoglobinase (C13) cysteine protease signature

    UniProtKB/Swiss-Prot: GPI8_HUMAN, Q92643
    Similarity: Belongs to the peptidase C13 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: GPI8_HUMAN, Q92643
    Function: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment
    signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl
    intermediate with the substrate protein

         Genatlas biochemistry entry for PIGK:
    phosphatidylinositol glycan,class K,mutated in K562 cell line,yeast GPI8 homolog,association with GPAA1 for GPI anchor
    attachment

    Enzyme Number (IUBMB): EC 3.-.-.-1

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: PIGK
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIGK
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate PIGK (see all 29):
    hsa-miR-320a hsa-miR-607 hsa-miR-640 hsa-miR-1197 hsa-miR-1260b hsa-miR-765 hsa-miR-938 hsa-miR-16-1*
    SwitchGear 3'UTR luciferase reporter plasmidPIGK 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PIGK (see all 7)
    OriGene shRNA RFP: PIGK
    OriGene siRNA: PIGK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIGK

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PIGK

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIGK (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIGK (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PIGK (NM_005482)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIGK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIGK 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PIGK
    Search LifeMap BioReagents cell lines for PIGK

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGK

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003756protein disulfide isomerase activity TAS12582175
    GO:0003923GPI-anchor transamidase activity TAS--
    GO:0004197cysteine-type endopeptidase activity IEA--
    GO:0005515protein binding IPI11483512
    GO:0034235contributes to GPI anchor binding TAS10793132


    PIGK for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PIGK:
     Decreased p24 protein expressi 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Post-translational modification: synthesis of GPI-anchored proteins
    Post-translational modification: synthesis of GPI-anchored proteins1.00
    Glycosylphosphatidylinositol(GPI)-anchor biosynthesis0.79
    2Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.15
    3Attachment of GPI anchor to uPAR
    Attachment of GPI anchor to uPAR1.00
    4Metabolism
    Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for PIGK
        Attachment of GPI anchor to uPAR
    Metabolism of proteins
    Post-translational modification: synthesis of GPI-anchored proteins
    Post-translational protein modification


    2         Kegg Pathways  (Kegg details for PIGK):
        Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: GPI8_HUMAN, Q92643
    Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis


    PIGK for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIGK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/73 Interacting proteins for PIGK (Q926432, 3 ENSP000003598484) via UniProtKB, MINT, STRING, and/or I2D (see all 73)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALPPP051872, 3, ENSP000003758814MINT-8216721 I2D: score=3 STRING: ENSP00000375881
    PIGTQ969N23, ENSP000002790364I2D: score=6 STRING: ENSP00000279036
    ALG5Q9Y6733, ENSP000002398914I2D: score=2 STRING: ENSP00000239891
    SPTLC1O152693, ENSP000002625544I2D: score=2 STRING: ENSP00000262554
    ZMPSTE24O758443, ENSP000003618454I2D: score=2 STRING: ENSP00000361845
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS12582175
    GO:0006501C-terminal protein lipidation TAS--
    GO:0006508proteolysis IEA--
    GO:0016255attachment of GPI anchor to protein TAS--
    GO:0043687post-translational protein modification TAS--


    PIGK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PIGK for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PIGK

    10/519 HMDB Compounds for PIGK (see all 519)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
    3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
    3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
    3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
    3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
    3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
    3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--
    1 Novoseek chemical compound relationship for PIGK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipid 6.54 1 12802054 (1)

    Search CenterWatch for drugs/clinical trials and news about PIGK / GPI8 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PIGK gene: 
    NM_005482.2  

    Unigene Cluster for PIGK:

    Phosphatidylinositol glycan anchor biosynthesis, class K
    Hs.178305  [show with all ESTs]
    Unigene Representative Sequence: NM_005482
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370812(uc001dhk.3 uc010orj.2) ENST00000445065(uc009wbx.3)
    ENST00000487906 ENST00000359130(uc001dhl.1) ENST00000478391 ENST00000370813


    miRNA
    Products:
         
    OriGene 3'-UTR Clone: PIGK
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIGK
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate PIGK (see all 29):
    hsa-miR-320a hsa-miR-607 hsa-miR-640 hsa-miR-1197 hsa-miR-1260b hsa-miR-765 hsa-miR-938 hsa-miR-16-1*
    SwitchGear 3'UTR luciferase reporter plasmidPIGK 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PIGK (see all 7)
    OriGene shRNA RFP: PIGK
    OriGene siRNA: PIGK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIGK
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIGK (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIGK (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PIGK (NM_005482)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIGK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIGK 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PIGK
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PIGK
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIGK
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIGK

    Additional cDNA sequence: 

    AF022913.1 AK055071.1 AK304340.1 AK313015.1 BC020737.1 BX648473.1 Y07596.1 

    15 DOTS entries:

    DT.212890  DT.412841  DT.100768228  DT.100028580  DT.121365816  DT.100776627  DT.100748896  DT.95374692 
    DT.95374694  DT.121365796  DT.121365811  DT.40313624  DT.95374693  DT.91774023  DT.91774034 

    24/230 AceView cDNA sequences (see all 230):

    BM728438 AA719665 AI123406 BU629350 AI983193 AW628276 AI245742 AA994078 
    AA428977 BM693241 CR614831 BC020737 BU742217 AW612942 CR594196 F12669 
    NM_005482 AK055071 AA464095 BM741888 CB156139 F10280 AI539700 BG778094 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PIGK    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
    SP1:                                                              -                     
    SP2:                                                                                    
    SP3:              -     -     -                                   -                     


    ECgene alternative splicing isoforms for PIGK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PIGK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAATCCTGCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See PIGK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PIGK

    SOURCE GeneReport for Unigene cluster: Hs.178305
        SABiosciences Custom PCR Arrays for PIGK
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PIGK
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PIGK
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIGK
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIGK
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PIGK gene from 9/38 species (see all 38)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves PIGK1 phosphatidylinositol glycan anchor biosynthesis, class more 80.44(n)
    87.24(a)
      424556  NM_001031278.1  NP_001026449.1 
    lizard
    (Anolis carolinensis)
    Reptilia PIGK6
    --
    88(a)
    1 ↔ 1
    AAWZ02038094(316-4601)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.67462 Xenopus laevis transcribed sequence with weak similarity more 80(n)    BX846807.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pigk1 phosphatidylinositol glycan, class K 70.91(n)
    81.3(a)
      415239  NM_001002149.1  NP_001002149.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta EG:133E12.33
    CG44061
    GPI-anchor transamidase3
    CG44061
    62(a)3
    58.56(n)1
    59.64(a)1
      2C13
    311631  NM_130612.31  NP_569968.21 
    worm
    (Caenorhabditis elegans)
    Secernentea T05E11.63
    hpo-41
    haemoglobinase like3
    Protein HPO-41
    55(a)3
    59(n)1
    56.1(a)1
      IV(11108824-11110243)3
    1881311  NM_069675.21  NP_502076.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GPI8(YDR331W)4
    GPI81
    ER membrane glycoprotein subunit of the glycosylphosphatidylinositol more4
    Gpi8p1
    61.71(n)1
    60.59(a)1
      4(1129588-1130823)4
    8519311, 4  NP_010618.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G087501 peptidase C13-like protein 57.86(n)
    54.72(a)
      837397  NM_179285.1  NP_849616.1 
    rice
    (Oryza sativa)
    Liliopsida Os.242852 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.55(n)    AK072526.1 


    ENSEMBL Gene Tree for PIGK (if available)
    TreeFam Gene Tree for PIGK (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PIGK gene
    LGMN2  

    PIGK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2045 NCBI SNPs in PIGK are shown (see all 2045    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1832628681,2
    --77554206(+) CGGAGG/TTTCAC 1 -- ds50010--------
    rs1886182781,2
    --77554403(+) CCATGC/GCCAGC 1 -- ds50010--------
    rs111622691,2
    C,F,H,--77554453(+) CCTAAG/AAAAGT 1 -- ds50019Minor allele frequency- A:0.25NS EA NA WA 778
    rs1997151,2
    C,F,O,A,--77554542(+) GGGTCG/ATATCA 1 -- ds500115Minor allele frequency- A:0.49NA WA CSA EA 516
    rs1919449441,2
    --77554549(+) ATCATA/GTGATT 1 -- ds50010--------
    rs170998821,2
    C,F,H,--77554641(+) TGCAGG/ATGACA 1 -- ds500120Minor allele frequency- A:0.07NA NS EA CSA WA 2377
    rs760449751,2
    C,--77554647(+) TGACAA/CAAGAA 1 -- ds50010--------
    rs170998851,2
    C,F,H,--77554775(+) TTCACA/GGCACA 1 -- ut3119Minor allele frequency- G:0.07NA NS EA WA 2382
    rs1157283011,2
    C--77555034(+) TCATTG/TTTTTA 1 -- ut310--------
    rs1833193081,2
    --77555058(+) TGGTAA/TGTTTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PIGK (77554666 - 77685132 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PIGK
         1 Indel: 97408

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PIGK
    DNA2.0 Custom Variant and Variant Library Synthesis for PIGK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PIGK for disorders           About GeneDecksing

    OMIM gene information: 605087    OMIM disorders: --

    5 diseases for PIGK:    About MalaCards
    fungal meningitis    sleeping sickness    meningitis    malaria
    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: PIGK (1 document)

    Export disorders for PIGK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PIGK gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with PIGK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase. (PubMed id 9356492)1, 2, 3, 9 Yu J.... Medof M.E. (1997)
    2. Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge. (PubMed id 12582175)1, 2, 9 Ohishi K.... Kinoshita T. (2003)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8. (PubMed id 11483512)1, 2 Ohishi K.... Kinoshita T. (2001)
    7. Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins. (PubMed id 10793132)1, 2 Ohishi K.... Kinoshita T. (2000)
    8. Yeast Gpi8p is essential for GPI anchor attachment onto proteins. (PubMed id 8978684)1, 2 Benghezal M.... Conzelmann A. (1996)
    9. Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. (PubMed id 12802054)1, 9 Hong Y.... Kinoshita T. (2003)
    10. Proprotein interaction with the GPI transamidase. (PubMed id 12616539)1, 9 Chen R....Medof M.E. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10026 HGNC: 8965 AceView: PIGK Ensembl:ENSG00000142892 euGenes: HUgn10026
    ECgene: PIGK Kegg: 10026 H-InvDB: PIGK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PIGK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PIGK gene:
    Search GeneIP for patents involving PIGK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for PIGK  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PIGK   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PIGK  
     OriGene Protein Over-expression Lysate for PIGK   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for PIGK   OriGene 3'-UTR Clone for PIGK  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIGK   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIGK  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PIGK   OriGene Custom Protein Services for PIGK  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PIGK
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PIGK
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIGK
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIGK
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIGK
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIGK
     GenScript Custom Purified and Recombinant Proteins Services for PIGK GenScript cDNA clones with any tag delivered in your preferred vector for PIGK
     GenScript Custom Assay Services for PIGK GenScript Custom Superior Antibodies Services for PIGK
     GenScript Custom overexpressing Cell Line Services for PIGK CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PIGK promoter
     Search Chromatin IP Primers for PIGK
     RT2 qPCR Primer Assay in human, mouse, rat PIGK
     GNC Network for PIGK
     SABiosciences Custom PCR Arrays for PIGK
     Search Tocris compounds for PIGK
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PIGK antibodies
     PIGK proteins
     PIGK lysates
     Antibodies for PIGK
     See all of Abcam's Antibodies, Kits and Proteins for PIGK
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     PIGK Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for PIGK
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGK
     SwitchGear 3'UTR luciferase reporter plasmids for PIGK
     SwitchGear Promoter luciferase reporter plasmids for PIGK
     ThermoFisher Antibodies for PIGK
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIGK
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PIGK gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4