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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PIGH Gene

protein-coding   GIFtS: 55
GCID: GC14M068056

phosphatidylinositol glycan anchor biosynthesis, class H

(Previous names: phosphatidylinositol glycan, class H )
 Explore 2 diseases affiliated with
PIGH via our new
 Human Malady Compendium 
Biological research products
for PIGH
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Phosphatidylinositol Glycan Anchor Biosynthesis, Class H1 2     PIG-H2 3
GPI-H1 2     Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit H2
Phosphatidylinositol Glycan, Class H1 2     Phosphatidylinositol-Glycan Biosynthesis, Class H Protein2
Phosphatidylinositol-Glycan Biosynthesis Class H Protein2 3     EC 2.4.1.1983

External Ids:    HGNC: 89641   Entrez Gene: 52832   Ensembl: ENSG000001005647   OMIM: 6001545   UniProtKB: Q144423   

Export aliases for PIGH gene to outside databases

Previous GC identifers: GC14M065561 GC14M061849 GC14M066046 GC14M067125 GC14M048225


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PIGH:
This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol
(GPI)-anchor biosynthesis. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor
proteins to the cell surface. The protein encoded by this gene is a subunit of the GPI N-acetylglucosaminyl (GlcNAc)
transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PIGH_HUMAN, Q14442
Function: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to
phosphatidylinositol, the first step of GPI biosynthesis

Gene Wiki entry for PIGH


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PIGH gene promoter:
         HOXA9   HOXA9B   NCX/Ncx   Pax-2   Pax-2a   Pax-2b   STAT3   Meis-1a   En-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIGH promoter sequence
   Search SABiosciences Chromatin IP Primers for PIGH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIGH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.1   Ensembl cytogenetic band:  14q24.1   HGNC cytogenetic band: 14q24.1

PIGH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIGH gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M068056:  view genomic region     (about GC identifiers)

Start:
68,048,672 bp from pter      End:
68,067,017 bp from pter
Size:
18,346 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PIGH_HUMAN, Q14442 (See protein sequence)
Recommended Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit H  
Size: 188 amino acids; 21081 Da
Subunit: Associates with PIGA, PIGC, PIGP, PIGQ and DPM2. The latter is not essential for activity
Subcellular location: Cytoplasm
Secondary accessions: B2RAA4

Explore the universe of human proteins at neXtProt for PIGH: NX_Q14442

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14442

  • PIGH Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004560.1  
    ENSEMBL proteins: 
     ENSP00000453759   ENSP00000216452   ENSP00000452816   ENSP00000453394   ENSP00000453158  
     ENSP00000452924   ENSP00000452974   ENSP00000454061   ENSP00000453733   ENSP00000452996  
    Reactome Protein details: Q14442
    Human Recombinant Protein Products: 
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PIGH

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000506glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IDA10944123
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--


    PIGH for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PIGH for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019328 GPI-GlcNAc_Trfase_PIG-H_dom

    Graphical View of Domain Structure for InterPro Entry Q14442

    ProtoNet protein and cluster: Q14442

    UniProtKB/Swiss-Prot: PIGH_HUMAN, Q14442
    Similarity: Belongs to the PIGH family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PIGH_HUMAN, Q14442
    Function: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to
    phosphatidylinositol, the first step of GPI biosynthesis
    Catalytic activity: UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP +
    6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol

         Genatlas biochemistry entry for PIGH:
    glycosyl-phosphatidylinositol (GPI) anchor synthesis,class H

    Enzyme Number (IUBMB): EC 2.4.1.1981

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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate PIGH (see all 11):
    hsa-miR-7 hsa-miR-646 hsa-miR-3922-3p hsa-miR-135b hsa-miR-2116* hsa-miR-802 hsa-miR-3176 hsa-miR-892a
    SwitchGear 3'UTR luciferase reporter plasmidPIGH 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity TAS8900170
    GO:0017176phosphatidylinositol N-acetylglucosaminyltransferase activity IEA--


    PIGH for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PIGH:
     Decreased Tat-dependent transc 

    Animal Models:
         1 MGI phenotypic allele for Pigh (no phenotypes)

    PIGH for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Post-translational modification: synthesis of GPI-anchored proteins
    Post-translational modification: synthesis of GPI-anchored proteins1.00
    Synthesis of glycosylphosphatidylinositol (GPI)0.64
    Glycosylphosphatidylinositol(GPI)-anchor biosynthesis0.79
    2Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.15
    3Metabolism
    Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for PIGH
        Metabolism of proteins
    Post-translational modification: synthesis of GPI-anchored proteins
    Post-translational protein modification
    Synthesis of glycosylphosphatidylinositol (GPI)


    2         Kegg Pathways  (Kegg details for PIGH):
        Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: PIGH_HUMAN, Q14442
    Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis


    PIGH for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIGH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for PIGH (Q144423 ENSP000002164524) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIGQQ9BRB33, ENSP000000262184I2D: score=3 STRING: ENSP00000026218
    PIGAP372873, ENSP000003698204I2D: score=3 STRING: ENSP00000369820
    DPM2ENSP000003221814STRING: ENSP00000322181
    PIGCENSP000002583244STRING: ENSP00000258324
    PIGLENSP000002256094STRING: ENSP00000225609
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS8900170
    GO:0006501C-terminal protein lipidation TAS--
    GO:0006506GPI anchor biosynthetic process TAS8900170
    GO:0016254preassembly of GPI anchor in ER membrane TAS--
    GO:0043687post-translational protein modification TAS--


    PIGH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PIGH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PIGH

    10/898 HMDB Compounds for PIGH (see all 898)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
    3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
    3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
    3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
    3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
    3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
    3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--
    3 Novoseek chemical compound relationships for PIGH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-acetylglucosamine 79 1 8806613 (1)
    udp-n-acetylglucosamine 78.6 1 8806613 (1)
    phosphatidylinositol 65.9 2 8806613 (1), 8900170 (1)

    Search CenterWatch for drugs/clinical trials and news about PIGH 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PIGH gene: 
    NM_004569.3  

    Unigene Cluster for PIGH:

    Phosphatidylinositol glycan anchor biosynthesis, class H
    Hs.553497  [show with all ESTs]
    Unigene Representative Sequence: NM_004569
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000561272 ENST00000216452(uc001xjr.1) ENST00000558987 ENST00000559118
    ENST00000560722 ENST00000558493 ENST00000558198 ENST00000561303 ENST00000558001
    ENST00000559581 ENST00000559415 ENST00000559097(uc010tsy.1)

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    hsa-miR-7 hsa-miR-646 hsa-miR-3922-3p hsa-miR-135b hsa-miR-2116* hsa-miR-802 hsa-miR-3176 hsa-miR-892a
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    Additional cDNA sequence: 

    AK293584.1 AK314108.1 BC004100.2 BC071849.1 BT006804.1 L19783.1 

    11 DOTS entries:

    DT.95161816  DT.447626  DT.100785747  DT.86821098  DT.75176454  DT.99928760  DT.100785745  DT.100785746 
    DT.95271597  DT.97836072  DT.101983119 

    24/185 AceView cDNA sequences (see all 185):

    BE463542 NM_004569 BX281998 AW956826 AI493850 BM711152 CB321995 BE744584 
    BM670658 AA846165 BE501846 AW268894 BF739762 AA909682 BC004100 CB047739 
    BU782713 BC071849 AI420231 BM449954 BM769219 BX374583 AI337017 AA394196 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PIGH    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for PIGH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PIGH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTAACAAAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See PIGH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PIGH

    SOURCE GeneReport for Unigene cluster: Hs.553497
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PIGH gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pigh1 , 5 phosphatidylinositol glycan anchor biosynthesis, class more1, 5 87.34(n)1
    88.77(a)1
      12 (35.51 cM)5
    1104171  NM_029988.21  NP_084264.11 
     790806735 
    chicken
    (Gallus gallus)
    Aves PIGH1 phosphatidylinositol glycan anchor biosynthesis, class more 70.27(n)
    71.35(a)
      423271  NM_001199701.1  NP_001186630.1 
    lizard
    (Anolis carolinensis)
    Reptilia PIGH6
    --
    72(a)
    1 ↔ 1
    GL343272.1(978749-985654)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.142102 Xenopus laevis transcribed sequence with weak similarity more 73.83(n)    BJ058220.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pigh1 phosphatidylinositol glycan anchor biosynthesis, class more 61.69(n)
    59.12(a)
      436838  NM_001002565.1  NP_001002565.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG144636
    --
    18(a)
    1 ↔ 1
    3R(3825592-3826639)


    ENSEMBL Gene Tree for PIGH (if available)
    TreeFam Gene Tree for PIGH (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PIGH gene

    PIGH for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PIGH
    PGOHUM00000247136


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/278 NCBI SNPs in PIGH are shown (see all 278    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1448180431,2
    --68055599(+) CATGAA/TGAAAA 2 -- ds5001 ut310--------
    rs49024961,2
    C,F,A,H,--68055613(+) AAGCAG/CATCCA 2 -- ds5001 ut3131Minor allele frequency- C:0.36NA NS EA WA CSA 2917
    rs1125851031,2
    --68055862(+) GAGAGG/TTTAGA 2 -- ds5001 ut311Minor allele frequency- T:0.50CSA 2
    rs37428751,2
    C,F,H,--68055884(+) AGTCCA/GAAGGA 2 -- ds5001 ut3129Minor allele frequency- G:0.08EA NS NA CSA WA 4664
    rs1485638891,2
    --68055919(+) TTCACA/CCTGAA 2 -- ut31 ds50010--------
    rs1462222261,2
    --68055993(+) TAATC-/TTTTATA 2 -- ut31 ds50010--------
    rs101621,2
    --68056092(-) CAGAAA/G/TTTGGA 4 -- ut311MN 184
    rs1926137721,2
    --68056168(+) AGTAAC/TAGAAA 2 -- ut310--------
    rs1845926591,2
    --68056385(+) TGTTTA/TTTTCG 2 -- ut31 ds50010--------
    rs1891152951,2
    --68056389(+) TTTTTC/TGTAAC 2 -- ds5001 ut310--------

    HapMap Linkage Disequilibrium report for PIGH (68048672 - 68067017 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PIGH
         1 CNV: 49401

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PIGH for disorders           About GeneDecksing

    OMIM gene information: 600154    OMIM disorders: --

    2 diseases for PIGH:    About MalaCards
    paroxysmal nocturnal hemoglobinuria    hemoglobinuria

    Human Genome Epidemiology (HuGE) Navigator: PIGH (1 document)

    Export disorders for PIGH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PIGH gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with PIGH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal assignment of genes involved in glycosylphosphatidylinositol anchor biosynthesis: implications for the pathogenesis of paroxysmal nocturnal hemoglobinuria. (PubMed id 8204896)1, 3, 9 Ware R.E....Seldin M.F. (1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1. (PubMed id 9463366)1, 2 Watanabe R....Kinoshita T. (1998)
    4. Correction of the class H defect in glycosylphosphatidylinositol anchor biosynthesis in Ltk- cells by a human cDNA clone. (PubMed id 8407896)1, 2 Kamitani T.... Yeh E.T. (1993)
    5. PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis, form a protein complex in the endoplasmic reticulum. (PubMed id 8900170)1, 9 Watanabe R....Inoue N. (1996)
    6. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. (PubMed id 10944123)1, 9 Watanabe R.... Kinoshita T. (2000)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    9. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5283 HGNC: 8964 AceView: PIGH Ensembl:ENSG00000100564 euGenes: HUgn5283
    ECgene: PIGH Kegg: 5283 H-InvDB: PIGH

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PIGH Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_557

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PIGH gene:
    Search GeneIP for patents involving PIGH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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