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PIGH Gene

protein-coding   GIFtS: 57
GCID: GC14M068056

Phosphatidylinositol Glycan Anchor Biosynthesis, Class H

(Previous names: phosphatidylinositol glycan, class H)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phosphatidylinositol Glycan Anchor Biosynthesis, Class H1 2     GPI-H2
Phosphatidylinositol Glycan, Class H1 2     Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit H2
Phosphatidylinositol-Glycan Biosynthesis Class H Protein2 3     Phosphatidylinositol-Glycan Biosynthesis, Class H Protein2
PIG-H2 3     EC 2.4.1.1983
Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit1     

External Ids:    HGNC: 89641   Entrez Gene: 52832   Ensembl: ENSG000001005647   OMIM: 6001545   UniProtKB: Q144423   

Export aliases for PIGH gene to outside databases

Previous GC identifers: GC14M065561 GC14M061849 GC14M066046 GC14M067125 GC14M048225


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PIGH Gene:
This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol
(GPI)-anchor biosynthesis. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor
proteins to the cell surface. The protein encoded by this gene is a subunit of the GPI N-acetylglucosaminyl
(GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the
endoplasmic reticulum. (provided by RefSeq, Jul 2008)

GeneCards Summary for PIGH Gene:
PIGH (phosphatidylinositol glycan anchor biosynthesis, class H) is a protein-coding gene. GO annotations related to this gene include phosphatidylinositol N-acetylglucosaminyltransferase activity.

UniProtKB/Swiss-Prot: PIGH_HUMAN, Q14442
Function: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to
phosphatidylinositol, the first step of GPI biosynthesis

Gene Wiki entry for PIGH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PIGH gene promoter:
         HOXA9   HOXA9B   NCX/Ncx   Pax-2   Pax-2a   Pax-2b   STAT3   Meis-1a   En-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIGH promoter sequence
   Search Chromatin IP Primers for PIGH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIGH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.1   Ensembl cytogenetic band:  14q24.1   HGNC cytogenetic band: 14q24.1

PIGH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIGH gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M068056:  view genomic region     (about GC identifiers)

Start:
68,048,672 bp from pter      End:
68,067,017 bp from pter
Size:
18,346 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PIGH_HUMAN, Q14442 (See protein sequence)
Recommended Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit H  
Size: 188 amino acids; 21081 Da
Subunit: Associates with PIGA, PIGC, PIGP, PIGQ and DPM2. The latter is not essential for activity
Secondary accessions: B2RAA4

Explore the universe of human proteins at neXtProt for PIGH: NX_Q14442

Explore proteomics data for PIGH at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys182
  • Modification sites at PhosphoSitePlus

  • See PIGH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004560.1  
    ENSEMBL proteins: 
     ENSP00000453759   ENSP00000216452   ENSP00000452816   ENSP00000453394   ENSP00000453158  
     ENSP00000452924   ENSP00000452974   ENSP00000454061   ENSP00000453733   ENSP00000452996  
    Reactome Protein details: Q14442

    PIGH Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PIGH

     
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    antibodies-online peptides for PIGH

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PIG: Phosphatidylinositol glycan anchor biosynthesis

    1 InterPro protein domain:
     IPR019328 GPI-GlcNAc_Trfase_PIG-H_dom

    Graphical View of Domain Structure for InterPro Entry Q14442

    ProtoNet protein and cluster: Q14442

    UniProtKB/Swiss-Prot: PIGH_HUMAN, Q14442
    Similarity: Belongs to the PIGH family


    Find genes that share domains with PIGH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIGH_HUMAN, Q14442
    Function: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to
    phosphatidylinositol, the first step of GPI biosynthesis
    Catalytic activity: UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP +
    6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol

         Genatlas biochemistry entry for PIGH:
    glycosyl-phosphatidylinositol (GPI) anchor synthesis,class H

         Enzyme Number (IUBMB): EC 2.4.1.1981

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity TAS8900170
    GO:0017176phosphatidylinositol N-acetylglucosaminyltransferase activity IEA--
         
    Find genes that share ontologies with PIGH           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PIGH:
     Decreased Tat-dependent transc 

         1 MGI phenotypic allele for Pigh (no phenotypes)

    Find genes that share phenotypes with PIGH           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PIGH

    miRNA
    Products:
        
    miRTarBase miRNAs that target PIGH:
    hsa-mir-7-5p (MIRT025861)

    Block miRNA regulation of human, mouse, rat PIGH using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PIGH (see all 11):
    hsa-miR-7 hsa-miR-646 hsa-miR-3922-3p hsa-miR-135b hsa-miR-2116* hsa-miR-802 hsa-miR-3176 hsa-miR-892a
    SwitchGear 3'UTR luciferase reporter plasmidPIGH 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat PIGH

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PIGH_HUMAN, Q14442: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    mitochondrion4
    nucleus4
    cytosol3
    plasma membrane3

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000506glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IDA10944123
    GO:0005634nucleus ----
    GO:0005730nucleolus ----
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion ----

    Find genes that share ontologies with PIGH           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PIGH About    
    See pathways by source

    SuperPathContained pathways About
    1Post-translational modification- synthesis of GPI-anchored proteins
    Post-translational modification- synthesis of GPI-anchored proteins0.76
    Synthesis of glycosylphosphatidylinositol (GPI)0.00
    Glycosylphosphatidylinositol(GPI)-anchor biosynthesis0.76
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30
    3Metabolism
    Metabolic pathways0.38


    Find genes that share SuperPaths with PIGH           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for PIGH
        Synthesis of glycosylphosphatidylinositol (GPI)


    2 Kegg Pathways  (Kegg details for PIGH):
        Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: PIGH_HUMAN, Q14442
    Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PIGH
    Interactions:

        GeneGlobe Interaction Network for PIGH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for PIGH (Q144423 ENSP000002164524) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIGQQ9BRB33, ENSP000000262184I2D: score=3 STRING: ENSP00000026218
    PIGAP372873, ENSP000003698204I2D: score=3 STRING: ENSP00000369820
    DPM2ENSP000003221814STRING: ENSP00000322181
    PIGCENSP000002583244STRING: ENSP00000258324
    PIGLENSP000002256094STRING: ENSP00000225609
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS8900170
    GO:0006501C-terminal protein lipidation TAS--
    GO:0006506GPI anchor biosynthetic process TAS8900170
    GO:0016254preassembly of GPI anchor in ER membrane TAS--
    GO:0043687post-translational protein modification TAS--

    Find genes that share ontologies with PIGH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PIGH

    Selected HMDB Compounds for PIGH (see all 898)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
    3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
    3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
    3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
    3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
    3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
    3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--

    3 Novoseek inferred chemical compound relationships for PIGH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-acetylglucosamine 79 1 8806613 (1)
    udp-n-acetylglucosamine 78.6 1 8806613 (1)
    phosphatidylinositol 65.9 2 8806613 (1), 8900170 (1)



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PIGH gene: 
    NM_004569.3  

    Unigene Cluster for PIGH:

    Phosphatidylinositol glycan anchor biosynthesis, class H
    Hs.553497  [show with all ESTs]
    Unigene Representative Sequence: NM_004569
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000561272 ENST00000216452(uc001xjr.1) ENST00000558987 ENST00000559118
    ENST00000560722 ENST00000558493 ENST00000558198 ENST00000561303 ENST00000558001
    ENST00000559581 ENST00000559415 ENST00000559097(uc010tsy.1)
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    hsa-miR-7 hsa-miR-646 hsa-miR-3922-3p hsa-miR-135b hsa-miR-2116* hsa-miR-802 hsa-miR-3176 hsa-miR-892a
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    Additional mRNA sequence: 

    AK293584.1 AK314108.1 BC004100.2 BC071849.1 BT006804.1 L19783.1 

    11 DOTS entries:

    DT.95161816  DT.447626  DT.100785747  DT.86821098  DT.75176454  DT.99928760  DT.100785745  DT.100785746 
    DT.95271597  DT.97836072  DT.101983119 

    Selected AceView cDNA sequences (see all 185):

    NM_004569 BM449954 BX374583 AI332729 AA846165 BP336801 AA394196 BM981317 
    AW956826 BF739762 AI420231 BM711152 AW301585 CR605373 BM670658 BE501846 
    AI337017 BP354216 CB321995 AI277505 AW026242 BU782713 BM769219 AW629157 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PIGH    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for PIGH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PIGH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAACAAAGA
    PIGH Expression
    About this image

    PIGH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIGH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553497
        Custom PCR Arrays for PIGH
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PIGH gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pigh1 , 5 phosphatidylinositol glycan anchor biosynthesis, class more1, 5 87.34(n)1
    88.77(a)1
      12 (35.51 cM)5
    1104171  NM_029988.21  NP_084264.11 
     790806735 
    chicken
    (Gallus gallus)
    Aves PIGH1 phosphatidylinositol glycan anchor biosynthesis, class more 70.27(n)
    71.35(a)
      423271  NM_001199701.1  NP_001186630.1 
    lizard
    (Anolis carolinensis)
    Reptilia PIGH6
    phosphatidylinositol glycan anchor biosynthesis, c...
    71(a)
    1 ↔ 1
    GL343272.1(978740-985865)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.142102 Xenopus laevis transcribed sequence with weak similarity more 73.83(n)    BJ058220.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pigh1 phosphatidylinositol glycan anchor biosynthesis, class more 61.69(n)
    59.12(a)
      436838  NM_001002565.2  NP_001002565.1 


    ENSEMBL Gene Tree for PIGH (if available)
    TreeFam Gene Tree for PIGH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PIGH gene

    Find genes that share paralogs with PIGH           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PIGH
    PGOHUM00000247136


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PIGH (see all 304)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1999097481,2
    --68056867(+) TCAAGC/GAGTCC 2 S C mis10--------
    rs65737851,2
    C,F,A,H--68056914(+) AATGCG/AGAGTC 1 -- int122Minor allele frequency- A:0.09NS EA NA WA 2482
    rs341860991,2
    C--68056966(+) GCAAA-/TTTTTT 1 -- int10--------
    rs348704061,2
    C--68056967(+) GCAAA-/TTTTTT 1 -- int12Minor allele frequency- T:0.25NA 4
    rs80105741,2
    C,F--68057031(+) GTGGCG/ACAATC 1 -- int14Minor allele frequency- A:0.38NA CSA 8
    rs790301341,2
    C--68057113(+) TACAGG/TTGCTC 1 -- int10--------
    rs1847041841,2
    --68057222(+) AGGCAC/TGAACC 1 -- int10--------
    rs1891517531,2
    --68057244(+) CTAATC/TTTTGT 1 -- int10--------
    rs1404248361,2
    C--68057346(+) GCTGGA/GATTAC 1 -- int10--------
    rs1815809281,2
    --68057398(+) TCTCAC/TCCACA 1 -- int10--------

    HapMap Linkage Disequilibrium report for PIGH (68048672 - 68067017 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PIGH:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv138n21CNV Loss19592680
    nsv470651CNV Gain18288195
    nsv902066CNV Gain21882294
    nsv456331CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600154    OMIM disorders: --


    Find genes that share disorders with PIGH           About GenesLikeMe

    Genetic Association Database (GAD): PIGH
    Human Genome Epidemiology (HuGE) Navigator: PIGH (1 document)

    Export disorders for PIGH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIGH gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with PIGH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal assignment of genes involved in glycosylphosphatidylinositol anchor biosynthesis: implications for the pathogenesis of paroxysmal nocturnal hemoglobinuria. (PubMed id 8204896)1, 3, 9 Ware R.E....Seldin M.F. (Blood 1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1. (PubMed id 9463366)1, 2 Watanabe R....Kinoshita T. (EMBO J. 1998)
    4. Correction of the class H defect in glycosylphosphatidylinositol anchor biosynthesis in Ltk- cells by a human cDNA clone. (PubMed id 8407896)1, 2 Kamitani T.... Yeh E.T. (J. Biol. Chem. 1993)
    5. PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis, form a protein complex in the endoplasmic reticulum. (PubMed id 8900170)1, 9 Watanabe R....Inoue N. (J. Biol. Chem. 1996)
    6. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. (PubMed id 10944123)1, 9 Watanabe R.... Kinoshita T. (EMBO J. 2000)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PubMed id 21103663)1 Schaafhausen A....MA1ller C.R. (Thromb. Haemost. 2011)
    10. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5283 HGNC: 8964 AceView: PIGH Ensembl:ENSG00000100564 euGenes: HUgn5283
    ECgene: PIGH Kegg: 5283 H-InvDB: PIGH

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PIGH Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_557

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PIGH gene:
    Search GeneIP for patents involving PIGH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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