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Aliases for PIGG Gene

Aliases for PIGG Gene

  • Phosphatidylinositol Glycan Anchor Biosynthesis Class G 2 3 5
  • Phosphatidylinositol-Glycan Biosynthesis Class G Protein 3 4
  • GPI7 3 4
  • GPI Ethanolamine Phosphate Transferase 2 3
  • Phosphatidylinositol Glycan, Class G 2
  • GPI7 Homolog 4
  • EC 2.-.-.- 4
  • RLGS1930 3
  • PRO4405 3
  • LAS21 3
  • MRT53 3
  • PIG-G 4
  • HGPI7 4

External Ids for PIGG Gene

Summaries for PIGG Gene

Entrez Gene Summary for PIGG Gene

  • This gene encodes an enzyme involved in glycosylphosphatidylinositol-anchor biosynthesis. The encoded protein, which is localized to the endoplasmic reticulum, is involved in transferring ethanoloamine phosphate to mannose 2 of glycosylphosphatidylinositol species H7 to form species H8. Allelic variants of this gene have been associated with intellectual disability, hypotonia, and early-onset seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

GeneCards Summary for PIGG Gene

PIGG (Phosphatidylinositol Glycan Anchor Biosynthesis Class G) is a Protein Coding gene. Diseases associated with PIGG include Mental Retardation, Autosomal Recessive 53 and Hypotonia. Among its related pathways are Glycosylphosphatidylinositol (GPI)-anchor biosynthesis and Metabolism of proteins. GO annotations related to this gene include phosphotransferase activity, for other substituted phosphate groups and CP2 mannose-ethanolamine phosphotransferase activity. An important paralog of this gene is PIGO.

UniProtKB/Swiss-Prot for PIGG Gene

  • Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.

Additional gene information for PIGG Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIGG Gene

Genomics for PIGG Gene

Regulatory Elements for PIGG Gene

Enhancers for PIGG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H000050 1.7 FANTOM5 Ensembl ENCODE dbSUPER 28.8 -445.5 -445542 6 PKNOX1 CBX3 TBL1XR1 ZSCAN4 YY1 ETS1 ZNF350 ZNF143 FOS RCOR1 PIGG PCGF3 ZNF718 ZNF141 GAK ENSG00000272588 LOC100129917 IDUA ZNF595 LOC105379580
GH04H000472 1.1 ENCODE 43.6 -25.4 -25407 2 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 PIGG CRIPAK ZNF721 PCGF3 GAK MAEA ENSG00000272588 ZNF718 ENSG00000281016 ABCA11P
GH04H000704 1.3 ENCODE dbSUPER 24.5 +207.1 207055 2 HDGF PKNOX1 ARNT ZNF493 SIN3A YBX1 ZNF2 GLIS2 ZNF143 ZNF207 PIGG ZNF718 PCGF3 LOC100129917 ENSG00000207009 ZNF141 ENSG00000272588 PDE6B ZNF732 CTBP1
GH04H000995 1.2 FANTOM5 Ensembl 14.4 +497.8 497750 3 TBP HDGF RB1 RAD21 ELK1 ATF7 CREM ZBTB2 SMAD5 ZBTB11 PIGG GAK PCGF3 CRIPAK MAEA SLC26A1 DGKQ ENSG00000250321 CPLX1 TMEM175
GH04H000123 1 ENCODE 16.1 -374.2 -374179 2 HDGF PKNOX1 ATF1 SIN3A FEZF1 ZNF2 YY1 GLIS2 ZNF143 ATF7 ZNF718 PIGG PCGF3 GAK ZNF141 SNX18P15
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PIGG on UCSC Golden Path with GeneCards custom track

Promoters for PIGG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000164669 -100 1801 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for PIGG Gene

Chromosome:
4
Start:
499,200 bp from pter
End:
540,196 bp from pter
Size:
40,997 bases
Orientation:
Plus strand

Genomic View for PIGG Gene

Genes around PIGG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIGG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIGG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIGG Gene

Proteins for PIGG Gene

  • Protein details for PIGG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5H8A4-PIGG_HUMAN
    Recommended name:
    GPI ethanolamine phosphate transferase 2
    Protein Accession:
    Q5H8A4
    Secondary Accessions:
    • B4DKC7
    • Q2TAK5
    • Q6UX31
    • Q7L5Y4
    • Q8N866
    • Q8NCC9
    • Q96SY9
    • Q9BVT7
    • Q9NXG5

    Protein attributes for PIGG Gene

    Size:
    983 amino acids
    Molecular mass:
    108173 Da
    Quaternary structure:
    • Forms a complex with PIGF. PIGF is required to stabilize it. Competes with PIGO for the binding of PIGF.
    SequenceCaution:
    • Sequence=AAQ88902.1; Type=Erroneous termination; Positions=311; Note=Translated as Gln.; Evidence={ECO:0000305}; Sequence=BAA91046.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55130.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for PIGG Gene

neXtProt entry for PIGG Gene

Post-translational modifications for PIGG Gene

No data available for DME Specific Peptides for PIGG Gene

Domains & Families for PIGG Gene

Gene Families for PIGG Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

Q5H8A4

UniProtKB/Swiss-Prot:

PIGG_HUMAN :
  • Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
Family:
  • Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
genes like me logo Genes that share domains with PIGG: view

Function for PIGG Gene

Molecular function for PIGG Gene

UniProtKB/Swiss-Prot Function:
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.

Enzyme Numbers (IUBMB) for PIGG Gene

Phenotypes From GWAS Catalog for PIGG Gene

Gene Ontology (GO) - Molecular Function for PIGG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0016780 phosphotransferase activity, for other substituted phosphate groups TAS --
GO:0051267 CP2 mannose-ethanolamine phosphotransferase activity IDA 15632136
genes like me logo Genes that share ontologies with PIGG: view

Phenotypes for PIGG Gene

GenomeRNAi human phenotypes for PIGG:
genes like me logo Genes that share phenotypes with PIGG: view

Human Phenotype Ontology for PIGG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for PIGG

CRISPR Products

Inhibitory RNA Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PIGG Gene

Localization for PIGG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIGG Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIGG gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PIGG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 15632136
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0030176 integral component of endoplasmic reticulum membrane IBA --
genes like me logo Genes that share ontologies with PIGG: view

Pathways & Interactions for PIGG Gene

genes like me logo Genes that share pathways with PIGG: view

UniProtKB/Swiss-Prot Q5H8A4-PIGG_HUMAN

  • Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.

Gene Ontology (GO) - Biological Process for PIGG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006506 GPI anchor biosynthetic process IDA 15632136
GO:0008152 metabolic process IEA --
GO:0016254 preassembly of GPI anchor in ER membrane TAS --
genes like me logo Genes that share ontologies with PIGG: view

No data available for SIGNOR curated interactions for PIGG Gene

Drugs & Compounds for PIGG Gene

(3) Drugs for PIGG Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
sphingosine 1-phosphate Pharma Full agonist, Agonist 0

(841) Additional Compounds for PIGG Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Dehydrosphinganine
  • (2S)-2-amino-1-hydroxyoctadecan-3-one
  • 1-Hydroxy-2-amino-3-oxo-octadecane
  • 2-Amino-1-hydroxy-3-Octadecanone
  • 3-Dehydro-D-sphinganine
  • 3-Dehydrosphinganine
16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
244215-65-4
genes like me logo Genes that share compounds with PIGG: view

Transcripts for PIGG Gene

Unigene Clusters for PIGG Gene

Phosphatidylinositol glycan anchor biosynthesis, class G:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIGG Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13a · 13b ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - -
SP6: - - - - - - -
SP7: - - - - - -
SP8:
SP9: - -
SP10: - -
SP11:
SP12:
SP13: - - -
SP14:
SP15: - -
SP16:
SP17:
SP18:

ExUns: 13c · 13d ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17a · 17b · 17c ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - - - - - - - -
SP11: - - - - - - - -
SP12: - -
SP13:
SP14: - - - - - -
SP15:
SP16: - - - -
SP17:
SP18:

Relevant External Links for PIGG Gene

GeneLoc Exon Structure for
PIGG
ECgene alternative splicing isoforms for
PIGG

Expression for PIGG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PIGG Gene

Protein differential expression in normal tissues from HIPED for PIGG Gene

This gene is overexpressed in Testis (25.5), Retina (14.9), Placenta (9.3), and Islet of Langerhans (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PIGG Gene



Protein tissue co-expression partners for PIGG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PIGG Gene:

PIGG

SOURCE GeneReport for Unigene cluster for PIGG Gene:

Hs.7099

Evidence on tissue expression from TISSUES for PIGG Gene

  • Nervous system(4.9)
  • Intestine(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with PIGG: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIGG Gene

Orthologs for PIGG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIGG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIGG 33 34
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia PIGG 33 34
  • 83.96 (n)
mouse
(Mus musculus)
Mammalia Pigg 33 16 34
  • 81.2 (n)
rat
(Rattus norvegicus)
Mammalia Pigg 33
  • 80.87 (n)
cow
(Bos Taurus)
Mammalia PIGG 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 73 (a)
OneToMany
-- 34
  • 64 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia PIGG 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIGG 33 34
  • 70.76 (n)
lizard
(Anolis carolinensis)
Reptilia PIGG 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pigg 33
  • 64 (n)
zebrafish
(Danio rerio)
Actinopterygii pigg 33
  • 62.27 (n)
PIGG 34
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004958 33
  • 44.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2144 33 34
  • 43.53 (n)
worm
(Caenorhabditis elegans)
Secernentea C27A12.9 34
  • 20 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPI13 34
  • 19 (a)
OneToMany
LAS21 36
Species where no ortholog for PIGG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIGG Gene

ENSEMBL:
Gene Tree for PIGG (if available)
TreeFam:
Gene Tree for PIGG (if available)

Paralogs for PIGG Gene

Paralogs for PIGG Gene

(1) SIMAP similar genes for PIGG Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with PIGG: view

Variants for PIGG Gene

Sequence variations from dbSNP and Humsavar for PIGG Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs372392424 Pathogenic, Mental retardation, autosomal recessive 53 (MRT53) [MIM:616917] 523,849(+) TGCTG(C/T)GCTCC intron-variant, nc-transcript-variant, reference, missense
rs869320772 Pathogenic 515,999(+) ACGTC(C/T)AACAG nc-transcript-variant, upstream-variant-2KB, reference, stop-gained, utr-variant-5-prime
rs869320773 Pathogenic 527,231(+) TCCAA(C/G)TAAGT nc-transcript-variant, splice-donor-variant
rs886041687 Pathogenic 500,583(+) CAGTT(-/T)ACTAT nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant, utr-variant-5-prime
rs1000001504 -- 526,483(+) AGGAG(-/C)GGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIGG Gene

Variant ID Type Subtype PubMed ID
esv2726675 CNV deletion 23290073
esv3599371 CNV loss 21293372
esv3599372 CNV loss 21293372
esv3893859 CNV gain 25118596
nsv1001899 CNV loss 25217958
nsv1006781 CNV gain 25217958
nsv1074125 CNV deletion 25765185
nsv1136804 CNV deletion 24896259
nsv461145 CNV gain 19166990
nsv461146 CNV gain 19166990
nsv469997 CNV gain 18288195
nsv508986 CNV insertion 20534489
nsv593202 CNV gain 21841781
nsv593204 CNV gain 21841781

Variation tolerance for PIGG Gene

Residual Variation Intolerance Score: 96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.72; 94.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIGG Gene

Human Gene Mutation Database (HGMD)
PIGG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIGG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIGG Gene

Disorders for PIGG Gene

MalaCards: The human disease database

(3) MalaCards diseases for PIGG Gene - From: HGMD, OMIM, ClinVar, Swiss-Prot, and GeneCards

Disorder Aliases PubMed IDs
mental retardation, autosomal recessive 53
  • glycosylphosphatidylinositol biosynthesis defect 13
hypotonia
intellectual disability
- elite association - COSMIC cancer census association via MalaCards
Search PIGG in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PIGG_HUMAN
  • Mental retardation, autosomal recessive 53 (MRT53) [MIM:616917]: A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Most MRT53 patients manifest severely delayed psychomotor development, hypotonia, and early-onset seizures. Additional features, such as cerebellar hypoplasia and ataxia have been observed in some patients. Note=The disease is caused by mutations affecting the gene represented in this entry. Cells from patients carrying PIGG disease-causing mutations show abnormal accumulation of the GPI precursors H7 and H7 and absence of mature GPI precursor H8, consistent with a loss of function. However, GPI-anchored proteins, including CD59, CD55, CD24 and CD16, are normally expressed at the cell surface of lymphocytes and granulocytes and CD59 exhibits sensitivity to bacterial phosphatidylinositol-specific phospholipase C, suggesting a normal structure. The role of PIGG in MRT53 etiology is not clear. {ECO:0000269 PubMed:26996948}.

Relevant External Links for PIGG

Genetic Association Database (GAD)
PIGG
Human Genome Epidemiology (HuGE) Navigator
PIGG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIGG
genes like me logo Genes that share disorders with PIGG: view

No data available for Genatlas for PIGG Gene

Publications for PIGG Gene

  1. GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol. (PMID: 15632136) Shishioh N … Kinoshita T (The Journal of biological chemistry 2005) 2 3 4 60
  2. Pathogenic Variants in PIGG Cause Intellectual Disability with Seizures and Hypotonia. (PMID: 26996948) Makrythanasis P … Murakami Y (American journal of human genetics 2016) 3 4 60
  3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 45 60
  4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 45 60
  5. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. (PMID: 19724895) Yoshida T … Yamada Y (International journal of molecular medicine 2009) 3 45 60

Products for PIGG Gene

Sources for PIGG Gene

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