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PIGG Gene

protein-coding   GIFtS: 53
GCID: GC04P000486

Phosphatidylinositol Glycan Anchor Biosynthesis, Class G

(Previous names: phosphatidylinositol glycan, class G)
  Search for PIGG
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phosphatidylinositol Glycan Anchor Biosynthesis, Class G1 2     RLGS19302
Phosphatidylinositol-Glycan Biosynthesis Class G Protein2 3     GPI Ethanolamine Phosphate Transferase 22
GPI72 3     EC 2.-.-.-3
Phosphatidylinositol Glycan, Class G1     PIG-G3
LAS212     GPI7 Homolog3
PRO44052     hGPI73

External Ids:    HGNC: 259851   Entrez Gene: 548722   Ensembl: ENSG000001742277   UniProtKB: Q5H8A43   

Export aliases for PIGG gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PIGG Gene:
PIGG (phosphatidylinositol glycan anchor biosynthesis, class G) is a protein-coding gene. GO annotations related to this gene include phosphotransferase activity, for other substituted phosphate groups and CP2 mannose-ethanolamine phosphotransferase activity. An important paralog of this gene is PIGO.

UniProtKB/Swiss-Prot: PIGG_HUMAN, Q5H8A4
Function: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
Transfers ethanolamine phosphate to the GPI second mannose




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006051.19  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PIGG gene promoter:
         SRF   FOXF2   AML1a   Pbx1a   SRF (504 AA)   LUN-1   FOXL1   CREB   deltaCREB   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIGG promoter sequence
   Search Chromatin IP Primers for PIGG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIGG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

PIGG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIGG gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P000486:  view genomic region     (about GC identifiers)

Start:
492,989 bp from pter      End:
533,985 bp from pter
Size:
40,997 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PIGG_HUMAN, Q5H8A4 (See protein sequence)
Recommended Name: GPI ethanolamine phosphate transferase 2  
Size: 983 amino acids; 108173 Da
Subunit: Forms a complex with PIGF. PIGF is required to stabilize it. Competes with PIGO for the binding of PIGF
Sequence caution: Sequence=AAQ88902.1; Type=Erroneous termination; Positions=311; Note=Translated as Gln;
Sequence=BAA91046.1; Type=Erroneous initiation; Sequence=BAB55130.1; Type=Erroneous initiation;
Secondary accessions: Q2TAK5 Q6UX31 Q7L5Y4 Q8N866 Q8NCC9 Q96SY9 Q9BVT7 Q9NXG5
Alternative splicing: 5 isoforms:  Q5H8A4-1   Q5H8A4-2   Q5H8A4-3   Q5H8A4-4   Q5H8A4-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PIGG: NX_Q5H8A4

Explore proteomics data for PIGG at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys407
  • Glycosylation2 at Asn194
  • Modification sites at PhosphoSitePlus

  • See PIGG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001120650.1  NP_001275980.1  NP_001275981.1  NP_001275982.1  NP_001275984.1  NP_001275986.1  NP_060203.3  

    ENSEMBL proteins: 
     ENSP00000427069   ENSP00000311750   ENSP00000415203   ENSP00000424800   ENSP00000426002  
     ENSP00000423596   ENSP00000424619   ENSP00000372494   ENSP00000421550   ENSP00000422410  
     ENSP00000296306   ENSP00000439240  
    Reactome Protein details: Q5H8A4

    PIGG Human Recombinant Protein Products:

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    Novus Biologicals PIGG Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PIGG

     
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    PIGG Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PIGG
    Cloud-Clone Corp. CLIAs for PIGG
    Search eBioscience for ELISAs for PIGG 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PIG: Phosphatidylinositol glycan anchor biosynthesis

    3 InterPro protein domains:
     IPR017849 Alkaline_Pase-like_a/b/a
     IPR002591 Phosphodiest/P_Trfase
     IPR017850 Alkaline_phosphatase_core

    Graphical View of Domain Structure for InterPro Entry Q5H8A4

    ProtoNet protein and cluster: Q5H8A4

    UniProtKB/Swiss-Prot: PIGG_HUMAN, Q5H8A4
    Similarity: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily


    Find genes that share domains with PIGG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIGG_HUMAN, Q5H8A4
    Function: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
    Transfers ethanolamine phosphate to the GPI second mannose

         Enzyme Number (IUBMB): EC 2.-.-.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0016740transferase activity ----
    GO:0016780phosphotransferase activity, for other substituted phosphate groups TAS--
    GO:0046872metal ion binding ----
    GO:0051267CP2 mannose-ethanolamine phosphotransferase activity IDA15632136
         
    Find genes that share ontologies with PIGG           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PIGG
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    miRNA
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    miRTarBase miRNAs that target PIGG:
    hsa-let-7b-5p (MIRT052101), hsa-mir-186-5p (MIRT021138)

    Block miRNA regulation of human, mouse, rat PIGG using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PIGG
    SwitchGear 3'UTR luciferase reporter plasmidPIGG 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIGG

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PIGG_HUMAN, Q5H8A4: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA15632136
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with PIGG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PIGG About    
    See pathways by source

    SuperPathContained pathways About
    1Post-translational modification- synthesis of GPI-anchored proteins
    Post-translational modification- synthesis of GPI-anchored proteins0.76
    Synthesis of glycosylphosphatidylinositol (GPI)0.00
    Glycosylphosphatidylinositol(GPI)-anchor biosynthesis0.76
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30


    Find genes that share SuperPaths with PIGG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for PIGG
        Synthesis of glycosylphosphatidylinositol (GPI)


    1 Kegg Pathway  (Kegg details for PIGG):
        Glycosylphosphatidylinositol(GPI)-anchor biosynthesis

    UniProtKB/Swiss-Prot: PIGG_HUMAN, Q5H8A4
    Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PIGG
    Interactions:

        Search GeneGlobe Interaction Network for PIGG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PIGG (Q5H8A43 ENSP000004152034) via UniProtKB, MINT, STRING, and/or I2D (see all 131)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206286Q8N1B43I2D: score=1 
    ENSG00000224455Q8N1B43I2D: score=1 
    ENSG00000225590Q8N1B43I2D: score=1 
    ENSG00000228425Q8N1B43I2D: score=1 
    ENSG00000236014Q8N1B43I2D: score=1 
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    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006501C-terminal protein lipidation TAS--
    GO:0006506GPI anchor biosynthetic process IDA15632136
    GO:0008152metabolic process ----
    GO:0016254preassembly of GPI anchor in ER membrane TAS--
    GO:0043687post-translational protein modification TAS--

    Find genes that share ontologies with PIGG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PIGG

    Selected HMDB Compounds for PIGG (see all 898)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
    3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
    3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
    3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
    3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
    3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
    3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PIGG gene (7 alternative transcripts): 
    NM_001127178.2  NM_001289051.1  NM_001289052.1  NM_001289053.1  NM_001289055.1  NM_001289057.1  NM_017733.4  

    Unigene Cluster for PIGG:

    Phosphatidylinositol glycan anchor biosynthesis, class G
    Hs.7099  [show with all ESTs]
    Unigene Representative Sequence: AK124537
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000504187 ENST00000310340(uc003gaj.4 uc011bux.2) ENST00000453061(uc003gak.4 uc010ibf.3 uc003gal.4)
    ENST00000504346 ENST00000502311 ENST00000503111(uc003gam.3) ENST00000511448
    ENST00000506402 ENST00000383028 ENST00000509768(uc011buw.2 uc003gan.3)
    ENST00000514953 ENST00000506898 ENST00000507493 ENST00000513679 ENST00000508562
    ENST00000511247 ENST00000508669 ENST00000503261
    miRNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): PIGG (NM_001127178)
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      QuantiTect SYBR Green Assays in human, mouse, rat PIGG
      QuantiFast Probe-based Assays in human, mouse, rat PIGG

    Additional mRNA sequence: 

    AB162713.1 AK000272.1 AK027465.1 AK074715.1 AK074815.1 AK097244.1 AK124537.1 AK296507.1 
    AK309107.1 AL137741.1 AL162084.1 AY358538.1 BC000937.2 BC001249.1 BC050262.1 BC110878.1 
    BC144576.1 

    Selected DOTS entries (see all 25):

    DT.91928988  DT.411539  DT.213084  DT.100775750  DT.425388  DT.91746356  DT.100745115  DT.121227532 
    DT.40276263  DT.86846644  DT.102831542  DT.100044190  DT.86856239  DT.91986634  DT.95356170  DT.97768962 
    DT.97789776  DT.121227452  DT.121227486  DT.121227547  DT.40130531  DT.95147745  DT.102831543  DT.91954556 

    Selected AceView cDNA sequences (see all 161):

    AW028130 BQ187290 AI471556 AW239182 AW193169 BU191836 AI421188 AK000272 
    AL698226 BC050262 BU634386 AK074715 AW451782 AK097244 BM980541 AK074815 
    CR619317 AW268135 AA974484 NM_017733 AI560517 BC001249 AK027465 AL162084 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PIGG (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13a · 13b ·
    SP1:                                      -     -                 -     -                                                           -                 -     -   
    SP2:                                      -     -                 -     -                                                                             -     -   
    SP3:                                -     -     -                 -     -                                                                             -     -   
    SP4:                                      -     -                 -     -                                               -     -     -           -               
    SP5:                                                              -     -                                                                                       

    ExUns: 13c · 13d ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17a · 17b · 17c ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b
    SP1:  -     -                 -     -     -     -           -                       -     -                           
    SP2:  -     -                 -     -     -     -           -                       -     -                           
    SP3:  -     -                 -     -     -     -           -                       -     -                           
    SP4:                                                                                                                  
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for PIGG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PIGG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTAAAGTCT
    PIGG Expression
    About this image

    PIGG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIGG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.7099
        Custom PCR Arrays for PIGG
    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PIGG gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pigg1 , 5 phosphatidylinositol glycan anchor biosynthesis, class more1, 5 81.2(n)1
    81.03(a)1
      5 (52.90 cM)5
    4339311  NM_001081234.11  NP_001074703.11 
     1083126095 
    chicken
    (Gallus gallus)
    Aves PIGG1 phosphatidylinositol glycan anchor biosynthesis, class more 70.76(n)
    71.14(a)
      427290  XM_004949323.1  XP_004949380.1 
    lizard
    (Anolis carolinensis)
    Reptilia PIGG6
    phosphatidylinositol glycan anchor biosynthesis, c...
    70(a)
    1 ↔ 1
    GL343201.1(419872-490617)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480432092   -- 74.81(n)    48043209 
    zebrafish
    (Danio rerio)
    Actinopterygii pigg1 phosphatidylinositol glycan anchor biosynthesis, class more 62.27(n)
    63.77(a)
      100538291  XM_003199835.2  XP_003199883.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG21441 CG2144 43.53(n)
    34.77(a)
      35685  NM_136448.3  NP_610292.2 
    worm
    (Caenorhabditis elegans)
    Secernentea C27A12.96
    Protein C27A12.9 (C27A12.9) mRNA, complete cds
    20(a)
    1 ↔ 1
    I(6061660-6068032) WBGene00016159
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LAS21(YJL062W)4 Integral plasma membrane protein involved in the synthesis more   --   10(317284-319776) 853384  NP_012473.1 


    ENSEMBL Gene Tree for PIGG (if available)
    TreeFam Gene Tree for PIGG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PIGG gene
    PIGO2  
    1 SIMAP similar gene for PIGG using alignment to 8 protein entries:     PIGG_HUMAN (see all proteins):
    DKFZp434C1712

    Find genes that share paralogs with PIGG           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PIGG (see all 1145)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1149623651,2
    F--495464(+) TCACTC/AACTGA 2 -- int11Minor allele frequency- A:0.01WA 118
    rs1869244681,2
    --495624(+) TACTTC/TCTAAT 2 -- int10--------
    rs1470319301,2
    --495637(+) GAGGGA/TTAGAA 2 -- int10--------
    rs769036461,2
    C,F--495647(+) AAATCG/AGTAAA 2 -- int13Minor allele frequency- A:0.18CSA WA 121
    rs1915603681,2
    --495679(+) TTCAGA/GCAGTG 2 -- int10--------
    rs1510590171,2
    C--495692(+) AACTG-/CTCTGGA 2 -- int10--------
    rs788186081,2
    F--495719(+) GGTGAG/CAGAGA 2 -- int11Minor allele frequency- C:0.03NA 120
    rs802490561,2
    C--495748(+) TGCCCG/TGCACC 2 -- int14Minor allele frequency- T:0.18CSA WA NA EA 360
    rs68281381,2
    C,H--495835(+) CTGATC/TTTCAG 2 -- int117Minor allele frequency- T:0.00NS EA NA WA CSA 780
    rs68419111,2
    C,H--495849(+) CACCGA/GTTTCT 2 -- int117Minor allele frequency- G:0.00NS EA NA WA CSA 792

    HapMap Linkage Disequilibrium report for PIGG (492989 - 533985 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PIGG:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726675CNV Deletion23290073
    nsv508986CNV Insertion20534489
    nsv878245CNV Loss21882294
    nsv461146CNV Gain19166990
    nsv469997CNV Gain18288195
    nsv461145CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PIGG
    DNA2.0 Custom Variant and Variant Library Synthesis for PIGG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with PIGG           About GenesLikeMe

    Genetic Association Database (GAD): PIGG
    Human Genome Epidemiology (HuGE) Navigator: PIGG (4 documents)

    Export disorders for PIGG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIGG gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with PIGG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol. (PubMed id 15632136)1, 2, 3 Shishioh N.... Kinoshita T. (J. Biol. Chem. 2005)
    2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    4. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. (PubMed id 19724895)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2009)
    5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    9. The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity. (PubMed id 23864651)1 Huang X....Wheeler M.B. (Mol. Endocrinol. 2013)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54872 HGNC: 25985 AceView: FLJ20265 Ensembl:ENSG00000174227 euGenes: HUgn54872
    ECgene: PIGG Kegg: 54872 H-InvDB: PIGG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PIGG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PIGG gene:
    Search GeneIP for patents involving PIGG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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