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Aliases for PIGG Gene

Aliases for PIGG Gene

  • Phosphatidylinositol Glycan Anchor Biosynthesis Class G 2 3 5
  • Phosphatidylinositol-Glycan Biosynthesis Class G Protein 3 4
  • GPI7 3 4
  • Phosphatidylinositol Glycan Anchor Biosynthesis, Class G 3
  • Phosphatidylinositol Glycan, Class G 2
  • GPI7 Homolog 4
  • EC 2.-.-.- 4
  • RLGS1930 3
  • PRO4405 3
  • LAS21 3
  • PIG-G 4
  • HGPI7 4

External Ids for PIGG Gene

Summaries for PIGG Gene

GeneCards Summary for PIGG Gene

PIGG (Phosphatidylinositol Glycan Anchor Biosynthesis Class G) is a Protein Coding gene. Diseases associated with PIGG include iridogoniodysgenesis, type 2. Among its related pathways are Transport to the Golgi and subsequent modification and Post-translational modification- synthesis of GPI-anchored proteins. GO annotations related to this gene include phosphotransferase activity, for other substituted phosphate groups and CP2 mannose-ethanolamine phosphotransferase activity.

UniProtKB/Swiss-Prot for PIGG Gene

  • Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIGG Gene

Genomics for PIGG Gene

Regulatory Elements for PIGG Gene

Promoters for PIGG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PIGG on UCSC Golden Path with GeneCards custom track

Genomic Location for PIGG Gene

Chromosome:
4
Start:
499,200 bp from pter
End:
540,196 bp from pter
Size:
40,997 bases
Orientation:
Plus strand

Genomic View for PIGG Gene

Genes around PIGG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIGG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIGG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIGG Gene

Proteins for PIGG Gene

  • Protein details for PIGG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5H8A4-PIGG_HUMAN
    Recommended name:
    GPI ethanolamine phosphate transferase 2
    Protein Accession:
    Q5H8A4
    Secondary Accessions:
    • B4DKC7
    • Q2TAK5
    • Q6UX31
    • Q7L5Y4
    • Q8N866
    • Q8NCC9
    • Q96SY9
    • Q9BVT7
    • Q9NXG5

    Protein attributes for PIGG Gene

    Size:
    983 amino acids
    Molecular mass:
    108173 Da
    Quaternary structure:
    • Forms a complex with PIGF. PIGF is required to stabilize it. Competes with PIGO for the binding of PIGF.
    SequenceCaution:
    • Sequence=AAQ88902.1; Type=Erroneous termination; Positions=311; Note=Translated as Gln.; Evidence={ECO:0000305}; Sequence=BAA91046.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55130.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PIGG Gene

neXtProt entry for PIGG Gene

Proteomics data for PIGG Gene at MOPED

Post-translational modifications for PIGG Gene

No data available for DME Specific Peptides for PIGG Gene

Domains & Families for PIGG Gene

Gene Families for PIGG Gene

Protein Domains for PIGG Gene

Graphical View of Domain Structure for InterPro Entry

Q5H8A4

UniProtKB/Swiss-Prot:

PIGG_HUMAN :
  • Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
Family:
  • Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
genes like me logo Genes that share domains with PIGG: view

Function for PIGG Gene

Molecular function for PIGG Gene

UniProtKB/Swiss-Prot Function:
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.

Enzyme Numbers (IUBMB) for PIGG Gene

Phenotypes for PIGG Gene

GenomeRNAi human phenotypes for PIGG:
genes like me logo Genes that share phenotypes with PIGG: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PIGG

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIGG Gene

Localization for PIGG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIGG Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIGG Gene COMPARTMENTS Subcellular localization image for PIGG gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for PIGG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PIGG: view

Pathways & Interactions for PIGG Gene

genes like me logo Genes that share pathways with PIGG: view

UniProtKB/Swiss-Prot Q5H8A4-PIGG_HUMAN

  • Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.

Gene Ontology (GO) - Biological Process for PIGG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with PIGG: view

No data available for SIGNOR curated interactions for PIGG Gene

Drugs & Compounds for PIGG Gene

(3) Drugs for PIGG Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
Sphingosine-1-phosphate Pharma Full agonist, Agonist Endogenous agonist at S1P1-5 0

(841) Additional Compounds for PIGG Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Dehydrosphinganine
  • (2S)-2-amino-1-hydroxyoctadecan-3-one
  • 1-Hydroxy-2-amino-3-oxo-octadecane
  • 2-Amino-1-hydroxy-3-Octadecanone
  • 3-Dehydro-D-sphinganine
  • 3-Dehydrosphinganine
16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
244215-65-4
genes like me logo Genes that share compounds with PIGG: view

Transcripts for PIGG Gene

Unigene Clusters for PIGG Gene

Phosphatidylinositol glycan anchor biosynthesis, class G:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIGG Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13a · 13b ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - -
SP6: - - - - - - -
SP7: - - - - - -
SP8:
SP9: - -
SP10: - -
SP11:
SP12:
SP13: - - -
SP14:
SP15: - -
SP16:
SP17:
SP18:

ExUns: 13c · 13d ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17a · 17b · 17c ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - - - - - - - -
SP11: - - - - - - - -
SP12: - -
SP13:
SP14: - - - - - -
SP15:
SP16: - - - -
SP17:
SP18:

Relevant External Links for PIGG Gene

GeneLoc Exon Structure for
PIGG
ECgene alternative splicing isoforms for
PIGG

Expression for PIGG Gene

mRNA expression in normal human tissues for PIGG Gene

Protein differential expression in normal tissues from HIPED for PIGG Gene

This gene is overexpressed in Testis (25.5), Retina (14.9), Placenta (9.3), and Islet of Langerhans (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIGG Gene



SOURCE GeneReport for Unigene cluster for PIGG Gene Hs.7099

genes like me logo Genes that share expression patterns with PIGG: view

Protein tissue co-expression partners for PIGG Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PIGG Gene

Orthologs for PIGG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIGG Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PIGG 35
  • 83.96 (n)
  • 84.07 (a)
PIGG 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pigg 35
  • 81.2 (n)
  • 81.03 (a)
Pigg 16
Pigg 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PIGG 35
  • 99.42 (n)
  • 99.49 (a)
PIGG 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910143 35
  • 80.87 (n)
  • 81.08 (a)
cow
(Bos Taurus)
Mammalia PIGG 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIGG 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
chicken
(Gallus gallus)
Aves PIGG 35
  • 70.76 (n)
  • 71.14 (a)
PIGG 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIGG 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pigg 35
  • 64 (n)
  • 64.07 (a)
zebrafish
(Danio rerio)
Actinopterygii pigg 35
  • 62.27 (n)
  • 63.77 (a)
PIGG 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004958 35
  • 44.98 (n)
  • 34.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2144 35
  • 43.53 (n)
  • 34.77 (a)
CG2144 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C27A12.9 36
  • 20 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPI13 36
  • 19 (a)
OneToMany
LAS21 38
Species with no ortholog for PIGG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIGG Gene

ENSEMBL:
Gene Tree for PIGG (if available)
TreeFam:
Gene Tree for PIGG (if available)

Paralogs for PIGG Gene

(1) SIMAP similar genes for PIGG Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with PIGG: view

No data available for Paralogs for PIGG Gene

Variants for PIGG Gene

Sequence variations from dbSNP and Humsavar for PIGG Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs13115344 - 521,700(+) ACTGC(A/G)CAGAA nc-transcript-variant, reference, synonymous-codon, missense
rs7666425 - 523,672(+) GCCTC(C/T)GTGTG intron-variant, nc-transcript-variant, reference, missense
rs13114026 - 527,064(+) TCTCT(A/G)TCCTG nc-transcript-variant, reference, synonymous-codon, missense, utr-variant-3-prime
rs1127410 - 539,212(+) AGTTT(C/T)CACGT nc-transcript-variant, downstream-variant-500B, reference, missense
VAR_057680 -

Structural Variations from Database of Genomic Variants (DGV) for PIGG Gene

Variant ID Type Subtype PubMed ID
nsv461145 CNV Gain 19166990
nsv469997 CNV Gain 18288195
nsv461146 CNV Gain 19166990
nsv878245 CNV Loss 21882294
esv2726675 CNV Deletion 23290073
nsv508986 CNV Insertion 20534489

Variation tolerance for PIGG Gene

Residual Variation Intolerance Score: 96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.72; 94.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIGG Gene

HapMap Linkage Disequilibrium report
PIGG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIGG Gene

Disorders for PIGG Gene

MalaCards: The human disease database

(1) MalaCards diseases for PIGG Gene - From: DISEASES

Disorder Aliases PubMed IDs
iridogoniodysgenesis, type 2
  • iridogoniodysgenesis, type 1
- elite association - COSMIC cancer census association via MalaCards
Search PIGG in MalaCards View complete list of genes associated with diseases

Relevant External Links for PIGG

Genetic Association Database (GAD)
PIGG
Human Genome Epidemiology (HuGE) Navigator
PIGG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIGG
genes like me logo Genes that share disorders with PIGG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIGG Gene

Publications for PIGG Gene

  1. GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol. (PMID: 15632136) Shishioh N. … Kinoshita T. (J. Biol. Chem. 2005) 2 3 4 67
  2. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. (PMID: 24639526) Carmon K.S. … Liu Q. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  3. The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity. (PMID: 23864651) Huang X. … Wheeler M.B. (Mol. Endocrinol. 2013) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3

Products for PIGG Gene

Sources for PIGG Gene

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