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Aliases for PIGG Gene

Aliases for PIGG Gene

  • Phosphatidylinositol Glycan Anchor Biosynthesis, Class G 2 3
  • Phosphatidylinositol-Glycan Biosynthesis Class G Protein 3 4
  • GPI7 3 4
  • GPI Ethanolamine Phosphate Transferase 2 3
  • Phosphatidylinositol Glycan, Class G 2
  • GPI7 Homolog 4
  • EC 2.-.-.- 4
  • RLGS1930 3
  • PRO4405 3
  • LAS21 3
  • PIG-G 4
  • HGPI7 4

External Ids for PIGG Gene

Summaries for PIGG Gene

GeneCards Summary for PIGG Gene

PIGG (Phosphatidylinositol Glycan Anchor Biosynthesis, Class G) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include phosphotransferase activity, for other substituted phosphate groups and CP2 mannose-ethanolamine phosphotransferase activity. An important paralog of this gene is PIGO.

UniProtKB/Swiss-Prot for PIGG Gene

  • Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIGG Gene

Genomics for PIGG Gene

Regulatory Elements for PIGG Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PIGG Gene

Start:
499,200 bp from pter
End:
540,196 bp from pter
Size:
40,997 bases
Orientation:
Plus strand

Genomic View for PIGG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIGG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIGG Gene

Proteins for PIGG Gene

  • Protein details for PIGG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5H8A4-PIGG_HUMAN
    Recommended name:
    GPI ethanolamine phosphate transferase 2
    Protein Accession:
    Q5H8A4
    Secondary Accessions:
    • B4DKC7
    • Q2TAK5
    • Q6UX31
    • Q7L5Y4
    • Q8N866
    • Q8NCC9
    • Q96SY9
    • Q9BVT7
    • Q9NXG5

    Protein attributes for PIGG Gene

    Size:
    983 amino acids
    Molecular mass:
    108173 Da
    Quaternary structure:
    • Forms a complex with PIGF. PIGF is required to stabilize it. Competes with PIGO for the binding of PIGF
    SequenceCaution:
    • Sequence=AAQ88902.1; Type=Erroneous termination; Positions=311; Note=Translated as Gln.; Evidence={ECO:0000305}; Sequence=BAA91046.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55130.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PIGG Gene

neXtProt entry for PIGG Gene

Proteomics data for PIGG Gene at MOPED

Post-translational modifications for PIGG Gene

No data available for DME Specific Peptides for PIGG Gene

Domains for PIGG Gene

Gene Families for PIGG Gene

HGNC:
  • PIG :Phosphatidylinositol glycan anchor biosynthesis

Protein Domains for PIGG Gene

Graphical View of Domain Structure for InterPro Entry

Q5H8A4

UniProtKB/Swiss-Prot:

PIGG_HUMAN :
  • Q5H8A4
Family:
  • Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
genes like me logo Genes that share domains with PIGG: view

Function for PIGG Gene

Molecular function for PIGG Gene

UniProtKB/Swiss-Prot Function:
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.

Enzyme Numbers (IUBMB) for PIGG Gene

Gene Ontology (GO) - Molecular Function for PIGG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0016780 phosphotransferase activity, for other substituted phosphate groups TAS --
GO:0046872 metal ion binding --
GO:0051267 CP2 mannose-ethanolamine phosphotransferase activity IDA 15632136
genes like me logo Genes that share ontologies with PIGG: view

Animal Model Products

miRNA for PIGG Gene

miRTarBase miRNAs that target PIGG

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PIGG Gene

Localization for PIGG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIGG Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIGG Gene COMPARTMENTS Subcellular localization image for PIGG gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for PIGG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 15632136
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane --
GO:0030176 integral component of endoplasmic reticulum membrane IBA --
genes like me logo Genes that share ontologies with PIGG: view

Pathways for PIGG Gene

genes like me logo Genes that share pathways with PIGG: view

UniProtKB/Swiss-Prot Q5H8A4-PIGG_HUMAN

  • Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis

Gene Ontology (GO) - Biological Process for PIGG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0006506 GPI anchor biosynthetic process IDA 15632136
GO:0008152 metabolic process --
GO:0016254 preassembly of GPI anchor in ER membrane TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with PIGG: view

Compounds for PIGG Gene

(898) HMDB Compounds for PIGG Gene

Compound Synonyms Cas Number PubMed IDs
3-Dehydrosphinganine
  • 1-Hydroxy-2-amino-3-oxo-octadecane
16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • Sulfatide (d18:1/12:0)
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • Sulfatide (d18:1/14:0)
Not Available
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • Sulfatide (d18:1/16:0)
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • Sulfatide (d18:1/18:0)
244215-65-4
genes like me logo Genes that share compounds with PIGG: view

Transcripts for PIGG Gene

Unigene Clusters for PIGG Gene

Phosphatidylinositol glycan anchor biosynthesis, class G:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIGG

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIGG Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13a · 13b ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - -
SP6: - - - - - - -
SP7: - - - - - -
SP8:
SP9: - -
SP10: - -
SP11:
SP12:
SP13: - - -
SP14:
SP15: - -
SP16:
SP17:
SP18:

ExUns: 13c · 13d ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17a · 17b · 17c ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - - - - - - - -
SP11: - - - - - - - -
SP12: - -
SP13:
SP14: - - - - - -
SP15:
SP16: - - - -
SP17:
SP18:

Relevant External Links for PIGG Gene

GeneLoc Exon Structure for
PIGG
ECgene alternative splicing isoforms for
PIGG

Expression for PIGG Gene

mRNA expression in normal human tissues for PIGG Gene

Protein differential expression in normal tissues for PIGG Gene

This gene is overexpressed in Testis (25.5), Retina (14.9), Placenta (9.3), and Islet of Langerhans (9.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIGG Gene

SOURCE GeneReport for Unigene cluster for PIGG Gene Hs.7099

genes like me logo Genes that share expressions with PIGG: view

Expression partners for PIGG Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PIGG Gene

Orthologs for PIGG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIGG Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PIGG 35
  • 83.96 (n)
  • 84.07 (a)
PIGG 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pigg 35
  • 81.2 (n)
  • 81.03 (a)
Pigg 16
Pigg 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PIGG 35
  • 99.42 (n)
  • 99.49 (a)
PIGG 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910143 35
  • 80.87 (n)
  • 81.08 (a)
cow
(Bos Taurus)
Mammalia PIGG 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIGG 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
chicken
(Gallus gallus)
Aves PIGG 35
  • 70.76 (n)
  • 71.14 (a)
PIGG 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIGG 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pigg 35
  • 64 (n)
  • 64.07 (a)
zebrafish
(Danio rerio)
Actinopterygii pigg 35
  • 62.27 (n)
  • 63.77 (a)
PIGG 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004958 35
  • 44.98 (n)
  • 34.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2144 35
  • 43.53 (n)
  • 34.77 (a)
CG2144 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C27A12.9 36
  • 20 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPI13 36
  • 19 (a)
OneToMany
LAS21 38
Species with no ortholog for PIGG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIGG Gene

ENSEMBL:
Gene Tree for PIGG (if available)
TreeFam:
Gene Tree for PIGG (if available)

Paralogs for PIGG Gene

Paralogs for PIGG Gene

Selected SIMAP similar genes for PIGG Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with PIGG: view

Variants for PIGG Gene

Sequence variations from dbSNP and Humsavar for PIGG Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1127410 - 539,212(+) AGTTT(C/T)CACGT missense, reference, nc-transcript-variant
rs1135945 -- 522,797(+) TGCAC(A/G)CAGTA intron-variant, utr-variant-3-prime
rs1867188 -- 510,223(-) tagaa(A/C)caatg intron-variant
rs2289595 -- 506,820(-) TCTAC(A/C)TGTGT intron-variant
rs2304915 -- 506,016(-) TAAAA(G/T)GGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIGG Gene

Variant ID Type Subtype PubMed ID
nsv461145 CNV Gain 19166990
nsv469997 CNV Gain 18288195
nsv461146 CNV Gain 19166990
nsv878245 CNV Loss 21882294
esv2726675 CNV Deletion 23290073
nsv508986 CNV Insertion 20534489

Relevant External Links for PIGG Gene

HapMap Linkage Disequilibrium report
PIGG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIGG Gene

Disorders for PIGG Gene

Relevant External Links for PIGG

Genetic Association Database (GAD)
PIGG
Human Genome Epidemiology (HuGE) Navigator
PIGG

No disorders were found for PIGG Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PIGG Gene

Publications for PIGG Gene

  1. GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol. (PMID: 15632136) Shishioh N. … Kinoshita T. (J. Biol. Chem. 2005) 2 3 4
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  3. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. (PMID: 19724895) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2009) 3 48
  4. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 48
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for PIGG Gene

Sources for PIGG Gene

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