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Aliases for PIGF Gene

Aliases for PIGF Gene

  • Phosphatidylinositol Glycan Anchor Biosynthesis Class F 2 3 5
  • GPI11 Homolog 3 4
  • PIG-F 3 4
  • Phosphatidylinositol Glycan Anchor Biosynthesis, Class F 3
  • Phosphatidylinositol Glycan, Class F 2

External Ids for PIGF Gene

Previous GeneCards Identifiers for PIGF Gene

  • GC02M046826
  • GC02M046977
  • GC02M046782
  • GC02M046720
  • GC02M046661
  • GC02M046808
  • GC02M046545

Summaries for PIGF Gene

Entrez Gene Summary for PIGF Gene

  • This gene encodes a protein involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor, a glycolipid containing three mannose molecules in its core backbone, is found on many blood cells where it serves to anchor proteins to the cell surface. The encoded protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate to the third mannose in GPI. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for PIGF Gene

PIGF (Phosphatidylinositol Glycan Anchor Biosynthesis Class F) is a Protein Coding gene. Diseases associated with PIGF include pre-eclampsia and preeclampsia/eclampsia 1. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include ethanolaminephosphotransferase activity.

UniProtKB/Swiss-Prot for PIGF Gene

  • Involved in GPI-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of GPI.

Gene Wiki entry for PIGF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIGF Gene

Genomics for PIGF Gene

Regulatory Elements for PIGF Gene

Promoters for PIGF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PIGF on UCSC Golden Path with GeneCards custom track

Genomic Location for PIGF Gene

Chromosome:
2
Start:
46,580,937 bp from pter
End:
46,617,119 bp from pter
Size:
36,183 bases
Orientation:
Minus strand

Genomic View for PIGF Gene

Genes around PIGF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIGF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIGF Gene

Proteins for PIGF Gene

  • Protein details for PIGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07326-PIGF_HUMAN
    Recommended name:
    Phosphatidylinositol-glycan biosynthesis class F protein
    Protein Accession:
    Q07326
    Secondary Accessions:
    • Q8WW20

    Protein attributes for PIGF Gene

    Size:
    219 amino acids
    Molecular mass:
    24890 Da
    Quaternary structure:
    • Forms a complex with PIGG and PIGO. PIGF is required to stabilize PIGG and PIGO.

    Alternative splice isoforms for PIGF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIGF Gene

Proteomics data for PIGF Gene at MOPED

Post-translational modifications for PIGF Gene

No Post-translational modifications

Other Protein References for PIGF Gene

No data available for DME Specific Peptides for PIGF Gene

Domains & Families for PIGF Gene

Gene Families for PIGF Gene

Protein Domains for PIGF Gene

Suggested Antigen Peptide Sequences for PIGF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q07326

UniProtKB/Swiss-Prot:

PIGF_HUMAN :
  • Belongs to the PIGF family.
Family:
  • Belongs to the PIGF family.
genes like me logo Genes that share domains with PIGF: view

Function for PIGF Gene

Molecular function for PIGF Gene

GENATLAS Biochemistry:
glycosyl-phosphatidylinositol (GPI),anchor synthesis,24.9kDa,class F
UniProtKB/Swiss-Prot Function:
Involved in GPI-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of GPI.
genes like me logo Genes that share phenotypes with PIGF: view

Animal Models for PIGF Gene

MGI Knock Outs for PIGF:
  • Pigf tm1a(KOMP)Wtsi

Animal Model Products

  • Taconic Biosciences Mouse Models for PIGF

miRNA for PIGF Gene

miRTarBase miRNAs that target PIGF

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIGF Gene

Localization for PIGF Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIGF Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIGF Gene COMPARTMENTS Subcellular localization image for PIGF gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
extracellular 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PIGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PIGF: view

Pathways & Interactions for PIGF Gene

genes like me logo Genes that share pathways with PIGF: view

UniProtKB/Swiss-Prot Q07326-PIGF_HUMAN

  • Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.

Gene Ontology (GO) - Biological Process for PIGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006506 GPI anchor biosynthetic process IEA,ISS --
GO:0016254 preassembly of GPI anchor in ER membrane TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with PIGF: view

No data available for SIGNOR curated interactions for PIGF Gene

Drugs & Compounds for PIGF Gene

(7) Drugs for PIGF Gene - From: HMDB, Novoseek, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aflibercept Approved Pharma inhibitor Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Sphingosine Experimental Pharma 0
ziv-aflibercept Pharma antibody Therapeutic Antibodies 0
sphinganine Pharma 0
Sphingosine-1-phosphate Pharma Full agonist, Agonist Endogenous agonist at S1P1-5 0

(844) Additional Compounds for PIGF Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Dehydrosphinganine
  • (2S)-2-amino-1-hydroxyoctadecan-3-one
  • 1-Hydroxy-2-amino-3-oxo-octadecane
  • 2-Amino-1-hydroxy-3-Octadecanone
  • 3-Dehydro-D-sphinganine
  • 3-Dehydrosphinganine
16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
244215-65-4
genes like me logo Genes that share compounds with PIGF: view

Transcripts for PIGF Gene

Unigene Clusters for PIGF Gene

Phosphatidylinositol glycan anchor biosynthesis, class F:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIGF Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6
SP1: -
SP2: -
SP3:

Relevant External Links for PIGF Gene

GeneLoc Exon Structure for
PIGF
ECgene alternative splicing isoforms for
PIGF

Expression for PIGF Gene

mRNA expression in normal human tissues for PIGF Gene

SOURCE GeneReport for Unigene cluster for PIGF Gene Hs.468415

genes like me logo Genes that share expression patterns with PIGF: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PIGF Gene

Orthologs for PIGF Gene

This gene was present in the common ancestor of chordates.

Orthologs for PIGF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PIGF 35
  • 91.78 (n)
  • 89.95 (a)
PIGF 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIGF 35
  • 93.46 (n)
  • 92.69 (a)
PIGF 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pigf 35
  • 86.45 (n)
  • 87.67 (a)
Pigf 16
Pigf 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PIGF 35
  • 99.7 (n)
  • 99.54 (a)
PIGF 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pigf 35
  • 85.84 (n)
  • 84.47 (a)
oppossum
(Monodelphis domestica)
Mammalia PIGF 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIGF 36
  • 6 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIGF 35
  • 70.62 (n)
  • 69.41 (a)
PIGF 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIGF 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pigf 35
  • 63.93 (n)
  • 62.1 (a)
Str.8112 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1780 35
zebrafish
(Danio rerio)
Actinopterygii pigf 35
  • 59.14 (n)
  • 53 (a)
pigf 36
  • 53 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2777 35
Species with no ortholog for PIGF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PIGF Gene

ENSEMBL:
Gene Tree for PIGF (if available)
TreeFam:
Gene Tree for PIGF (if available)

Paralogs for PIGF Gene

genes like me logo Genes that share paralogs with PIGF: view

No data available for Paralogs for PIGF Gene

Variants for PIGF Gene

Sequence variations from dbSNP and Humsavar for PIGF Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs982710 -- 46,614,445(+) GCCAA(A/G)TGAAT intron-variant
rs896213 -- 46,590,505(-) ATTAG(A/G)GTGTA intron-variant
rs1060656 -- 46,598,831(-) ataac(C/T)gtata intron-variant
rs1137748 -- 46,598,683(-) ccact(C/G)ttctc intron-variant
rs1376406 -- 46,585,199(-) CTAAG(C/T)TTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIGF Gene

Variant ID Type Subtype PubMed ID
dgv1181e1 CNV Complex 17122850
dgv149e55 CNV Loss 17911159
nsv873996 CNV Gain 21882294
nsv521013 CNV Loss 19592680
nsv873997 CNV Loss 21882294

Variation tolerance for PIGF Gene

Residual Variation Intolerance Score: 75.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIGF Gene

HapMap Linkage Disequilibrium report
PIGF
Human Gene Mutation Database (HGMD)
PIGF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIGF Gene

Disorders for PIGF Gene

MalaCards: The human disease database

(2) MalaCards diseases for PIGF Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pre-eclampsia
  • preeclampsia
preeclampsia/eclampsia 1
  • preeclampsia
- elite association - COSMIC cancer census association via MalaCards
Search PIGF in MalaCards View complete list of genes associated with diseases

Relevant External Links for PIGF

Genetic Association Database (GAD)
PIGF
Human Genome Epidemiology (HuGE) Navigator
PIGF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIGF
genes like me logo Genes that share disorders with PIGF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIGF Gene

Publications for PIGF Gene

  1. Cloning of a human gene, PIG-F, a component of glycosylphosphatidylinositol anchor biosynthesis, by a novel expression cloning strategy. (PMID: 8463218) Inoue N. … Takeda J. (J. Biol. Chem. 1993) 2 3 4 23 67
  2. Structure and chromosomal localization of the GPI-anchor synthesis gene PIGF and its pseudogene psi PIGF. (PMID: 8575782) Ohishi K. … Kinoshita T. (Genomics 1995) 2 3 23
  3. Hypoxia increases placenta growth factor expression in human myocardium and cultured neonatal rat cardiomyocytes. (PMID: 19201345) Torry R.J. … Torry D.S. (J. Heart Lung Transplant. 2009) 3 23
  4. Characterization of the paracrine effects of human skeletal myoblasts transplanted in infarcted myocardium. (PMID: 18805052) Perez-Ilzarbe M. … PrA^sper F. (Eur. J. Heart Fail. 2008) 3 23
  5. Circulating proangiogenic molecules PIGF, SDF-1 and sVCAM-1 in patients with systemic lupus erythematosus. (PMID: 17964973) Robak E. … Robak T. (Eur. Cytokine Netw. 2007) 3 23

Products for PIGF Gene

Sources for PIGF Gene

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