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Aliases for PIGC Gene

Aliases for PIGC Gene

  • Phosphatidylinositol Glycan Anchor Biosynthesis, Class C 2 3
  • GPI2 3 4 6
  • Phosphatidylinositol-Glycan Biosynthesis Class C Protein 3 4
  • PIG-C 3 4
  • Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit C 3
  • Phosphatidylinositol-Glycan Biosynthesis, Class C Protein 3
  • Phosphatidylinositol N-Acetylglucosaminyltransferase 2
  • Phosphatidylinositol Glycan, Class C 2
  • EC 4

External Ids for PIGC Gene

Previous GeneCards Identifiers for PIGC Gene

  • GC01M169974
  • GC01M168039
  • GC01M168991
  • GC01M169649
  • GC01M169142
  • GC01M170628
  • GC01M170677
  • GC01M143634

Summaries for PIGC Gene

Entrez Gene Summary for PIGC Gene

  • This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. Two alternatively spliced transcripts that encode the same protein have been found for this gene. A pseudogene on chromosome 11 has also been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for PIGC Gene

PIGC (Phosphatidylinositol Glycan Anchor Biosynthesis, Class C) is a Protein Coding gene. Diseases associated with PIGC include lassa fever. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include phosphatidylinositol N-acetylglucosaminyltransferase activity.

UniProtKB/Swiss-Prot for PIGC Gene

  • Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis

Gene Wiki entry for PIGC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIGC Gene

Genomics for PIGC Gene

Regulatory Elements for PIGC Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PIGC Gene

172,370,189 bp from pter
172,444,090 bp from pter
73,902 bases
Minus strand

Genomic View for PIGC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIGC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIGC Gene

Proteins for PIGC Gene

  • Protein details for PIGC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphatidylinositol N-acetylglucosaminyltransferase subunit C
    Protein Accession:
    Secondary Accessions:
    • O14491

    Protein attributes for PIGC Gene

    297 amino acids
    Molecular mass:
    33583 Da
    Quaternary structure:
    • Associates with PIGA, PIGH, PIGP, PIGQ and DPM2. The latter is not essential for activity

neXtProt entry for PIGC Gene

Proteomics data for PIGC Gene at MOPED

Post-translational modifications for PIGC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIGC Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PIGC Gene

Domains for PIGC Gene

Gene Families for PIGC Gene

  • PIG :Phosphatidylinositol glycan anchor biosynthesis

Protein Domains for PIGC Gene


Suggested Antigen Peptide Sequences for PIGC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q92535
  • Belongs to the PIGC family.
genes like me logo Genes that share domains with PIGC: view

Function for PIGC Gene

Molecular function for PIGC Gene

GENATLAS Biochemistry:
glycosylphosphatidylinositol (GPI) anchor synthesis,class C
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
UniProtKB/Swiss-Prot Function:
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis

Enzyme Numbers (IUBMB) for PIGC Gene

Gene Ontology (GO) - Molecular Function for PIGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity TAS 8806613
GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity IEA --
genes like me logo Genes that share ontologies with PIGC: view

Animal Model Products

miRNA for PIGC Gene

miRTarBase miRNAs that target PIGC

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIGC

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PIGC Gene

Localization for PIGC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIGC Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for PIGC Gene COMPARTMENTS Subcellular localization image for PIGC gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for PIGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IDA 10944123
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PIGC: view

Pathways for PIGC Gene

genes like me logo Genes that share pathways with PIGC: view

UniProtKB/Swiss-Prot Q92535-PIGC_HUMAN

  • Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis

Interacting Proteins for PIGC Gene

Selected Interacting proteins: Q92535-PIGC_HUMAN for PIGC Gene via MINT I2D

Gene Ontology (GO) - Biological Process for PIGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0006506 GPI anchor biosynthetic process TAS 8806613
GO:0016254 preassembly of GPI anchor in ER membrane TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with PIGC: view

Compounds for PIGC Gene

(898) HMDB Compounds for PIGC Gene

Compound Synonyms Cas Number PubMed IDs
  • 1-Hydroxy-2-amino-3-oxo-octadecane
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • Sulfatide (d18:1/12:0)
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • Sulfatide (d18:1/14:0)
Not Available
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • Sulfatide (d18:1/16:0)
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • Sulfatide (d18:1/18:0)

(3) Novoseek inferred chemical compound relationships for PIGC Gene

Compound -log(P) Hits PubMed IDs
udp-n-acetylglucosamine 78.6 1
n-acetylglucosamine 76 1
phosphatidylinositol 61.9 1
genes like me logo Genes that share compounds with PIGC: view

Transcripts for PIGC Gene

Unigene Clusters for PIGC Gene

Phosphatidylinositol glycan anchor biosynthesis, class C:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIGC

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIGC Gene

No ASD Table

Relevant External Links for PIGC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PIGC Gene

mRNA expression in normal human tissues for PIGC Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for PIGC Gene

SOURCE GeneReport for Unigene cluster for PIGC Gene Hs.188456

genes like me logo Genes that share expressions with PIGC: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for PIGC Gene

Orthologs for PIGC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PIGC Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PIGC 35
  • 92.03 (n)
  • 95.96 (a)
-- 36
  • 88 (a)
  • 96 (a)
(Canis familiaris)
Mammalia PIGC 35
  • 90.12 (n)
  • 95.96 (a)
  • 96 (a)
(Mus musculus)
Mammalia Pigc 35
  • 86.53 (n)
  • 93.6 (a)
Pigc 16
Pigc 36
  • 93 (a)
(Pan troglodytes)
Mammalia PIGC 35
  • 99.1 (n)
  • 98.99 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Pigc 35
  • 86.53 (n)
  • 93.27 (a)
(Monodelphis domestica)
Mammalia PIGC 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia PIGC 36
  • 88 (a)
(Gallus gallus)
Aves PIGC 35
  • 72.52 (n)
  • 80 (a)
(Anolis carolinensis)
Reptilia PIGC 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732903 35
  • 71.28 (n)
  • 78.72 (a)
(Danio rerio)
Actinopterygii pigc 35
  • 59.43 (n)
  • 55.16 (a)
pigc 36
  • 54 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005923 35
  • 47.86 (n)
  • 39.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12077 35
  • 48.07 (n)
  • 38.77 (a)
CG12077 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea T20D3.8 35
  • 48.26 (n)
  • 35.14 (a)
T20D3.8 36
  • 33 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SETH1 35
  • 46.35 (n)
  • 36.5 (a)
(Oryza sativa)
Liliopsida Os02g0622200 35
  • 46.08 (n)
  • 34.04 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02137 35
  • 43.02 (n)
  • 33.04 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gpi2 35
  • 44.08 (n)
  • 32.6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
Species with no ortholog for PIGC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIGC Gene

Gene Tree for PIGC (if available)
Gene Tree for PIGC (if available)

Paralogs for PIGC Gene Pseudogenes for PIGC Gene

genes like me logo Genes that share paralogs with PIGC: view

No data available for Paralogs for PIGC Gene

Variants for PIGC Gene

Sequence variations from dbSNP and Humsavar for PIGC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
VAR_011360 -

Relevant External Links for PIGC Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PIGC Gene

Disorders for PIGC Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PIGC Gene in MalaCards »

(1) Diseases for PIGC Gene including...

(1) University of Copenhagen DISEASES for PIGC Gene

Relevant External Links for PIGC

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PIGC: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for PIGC Gene

Publications for PIGC Gene

  1. PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homologue of Saccharomyces cerevisiae GPI2. (PMID: 8806613) Inoue N. … Kinoshita T. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 23
  2. Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1. (PMID: 9325057) Hong Y. … Kinoshita T. (Genomics 1997) 2 3 4 23
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. (PMID: 10944123) Watanabe R. … Kinoshita T. (EMBO J. 2000) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PIGC Gene

Sources for PIGC Gene

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