Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PIGC Gene

protein-coding   GIFtS: 55
GCID: GC01M172339

Phosphatidylinositol Glycan Anchor Biosynthesis, Class C

(Previous names: phosphatidylinositol glycan, class C)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Phosphatidylinositol Glycan Anchor Biosynthesis, Class C1 2     Phosphatidylinositol N-Acetylglucosaminyltransferase1
GPI22 3 5     Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit C2
Phosphatidylinositol-Glycan Biosynthesis Class C Protein2 3     Phosphatidylinositol-Glycan Biosynthesis, Class C Protein2
PIG-C2 3     EC 2.4.1.1983
Phosphatidylinositol Glycan, Class C1     

External Ids:    HGNC: 89601   Entrez Gene: 52792   Ensembl: ENSG000001358457   OMIM: 6017305   UniProtKB: Q925353   
ORGUL members:         

Export aliases for PIGC gene to outside databases

Previous GC identifers: GC01M169974 GC01M168039 GC01M168991 GC01M169649 GC01M169142 GC01M170628 GC01M170677 GC01M143634


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PIGC Gene:
This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol
(GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to
anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc)
transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic
reticulum. Two alternatively spliced transcripts that encode the same protein have been found for this gene. A
pseudogene on chromosome 11 has also been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for PIGC Gene:
PIGC (phosphatidylinositol glycan anchor biosynthesis, class C) is a protein-coding gene. Diseases associated with PIGC include lassa fever, and malaria. GO annotations related to this gene include phosphatidylinositol N-acetylglucosaminyltransferase activity.

UniProtKB/Swiss-Prot: PIGC_HUMAN, Q92535
Function: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to
phosphatidylinositol, the first step of GPI biosynthesis

Gene Wiki entry for PIGC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PIGC gene promoter:
         AML1a   POU3F1   SREBP-1c   CUTL1   STAT5A   E47   SREBP-1b   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIGC promoter sequence
   Search Chromatin IP Primers for PIGC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIGC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23-q25   Ensembl cytogenetic band:  1q24.3   HGNC cytogenetic band: 1q23-q25

PIGC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIGC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M172339:  view genomic region     (about GC identifiers)

Start:
172,339,329 bp from pter      End:
172,413,230 bp from pter
Size:
73,902 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PIGC_HUMAN, Q92535 (See protein sequence)
Recommended Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit C  
Size: 297 amino acids; 33583 Da
Subunit: Associates with PIGA, PIGH, PIGP, PIGQ and DPM2. The latter is not essential for activity
Secondary accessions: O14491

Explore the universe of human proteins at neXtProt for PIGC: NX_Q92535

Explore proteomics data for PIGC at MOPED


See PIGC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_002633.1  NP_714969.1  

ENSEMBL proteins: 
 ENSP00000356701   ENSP00000356702   ENSP00000258324  
Reactome Protein details: Q92535

PIGC Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for PIGC
OriGene Custom MassSpec
OriGene Custom Protein Services for PIGC
GenScript Custom Purified and Recombinant Proteins Services for PIGC
Novus Biologicals PIGC Proteins
Novus Biologicals PIGC Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for PIGC

PIGC Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for PIGC
Novus Biologicals PIGC Antibodies
Abcam antibodies for PIGC
Cloud-Clone Corp. Antibodies for PIGC
Search ThermoFisher Antibodies for PIGC
LSBio Antibodies in human, mouse, rat for PIGC

PIGC Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for PIGC
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for PIGC
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for PIGC
Cloud-Clone Corp. CLIAs for PIGC


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
PIG: Phosphatidylinositol glycan anchor biosynthesis

1 InterPro protein domain:
 IPR009450 Plno_GlcNAc_GPI2

Graphical View of Domain Structure for InterPro Entry Q92535

ProtoNet protein and cluster: Q92535

UniProtKB/Swiss-Prot: PIGC_HUMAN, Q92535
Similarity: Belongs to the PIGC family


PIGC for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: PIGC_HUMAN, Q92535
Function: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to
phosphatidylinositol, the first step of GPI biosynthesis
Catalytic activity: UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP +
6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol

     Genatlas biochemistry entry for PIGC:
glycosylphosphatidylinositol (GPI) anchor synthesis,class C

     Enzyme Number (IUBMB): EC 2.4.1.1981

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity TAS8806613
GO:0017176phosphatidylinositol N-acetylglucosaminyltransferase activity IEA--
     
PIGC for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PIGC
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PIGC

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PIGC
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PIGC

miRNA
Products:
    
miRTarBase miRNAs that target PIGC:
hsa-mir-744-5p (MIRT037438), hsa-mir-98-5p (MIRT027669)

Block miRNA regulation of human, mouse, rat PIGC using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate PIGC:
hsa-miR-2115
SwitchGear 3'UTR luciferase reporter plasmidPIGC 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for PIGC
Predesigned siRNA for gene silencing in human, mouse, rat PIGC

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for PIGC

Clone
Products:
     
OriGene clones in human, mouse for PIGC (see all 12)
OriGene ORF clones in mouse, rat for PIGC
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): PIGC (NM_153747)
Sino Biological Human cDNA Clone for PIGC
DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIGC
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIGC

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for PIGC
Browse ESI BIO Cell Lines and PureStem Progenitors for PIGC 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGC


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
PIGC_HUMAN, Q92535: Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
endoplasmic reticulum5
plasma membrane3
peroxisome1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000506glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IDA10944123
GO:0005789endoplasmic reticulum membrane TAS--
GO:0016021integral component of membrane IEA--

PIGC for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for PIGC About    
See pathways by source

SuperPathContained pathways About
1Post-translational modification- synthesis of GPI-anchored proteins
Post-translational modification- synthesis of GPI-anchored proteins0.76
Synthesis of glycosylphosphatidylinositol (GPI)0.00
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis0.76
2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Post-translational protein modification0.43
Metabolism of proteins0.30
3Metabolism
Metabolic pathways0.38

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



1 Reactome Pathway for PIGC
    Synthesis of glycosylphosphatidylinositol (GPI)


2 Kegg Pathways  (Kegg details for PIGC):
    Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
Metabolic pathways

UniProtKB/Swiss-Prot: PIGC_HUMAN, Q92535
Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis


PIGC for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PIGC
Interactions:

    GeneGlobe Interaction Network for PIGC

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

Selected Interacting proteins for PIGC (Q925352, 3 ENSP000002583244) via UniProtKB, MINT, STRING, and/or I2D (see all 16)

InteractantInteraction Details
GeneCardExternal ID(s)
ZHX1Q9UKY12, 3, ENSP000002978574MINT-65062 I2D: score=5 STRING: ENSP00000297857
KLF10Q131182, 3, ENSP000002854074MINT-8259205 I2D: score=2 STRING: ENSP00000285407
PIGQQ9BRB33, ENSP000000262184I2D: score=3 STRING: ENSP00000026218
DPM2O947773, ENSP000003221814I2D: score=2 STRING: ENSP00000322181
PIGAENSP000003698204STRING: ENSP00000369820
About this table

Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006501C-terminal protein lipidation TAS--
GO:0006506GPI anchor biosynthetic process TAS8806613
GO:0016254preassembly of GPI anchor in ER membrane TAS--
GO:0043687post-translational protein modification TAS--
GO:0044267cellular protein metabolic process TAS--

PIGC for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for PIGC

Selected HMDB Compounds for PIGC (see all 898)    About this table
CompoundSynonyms CAS #PubMed Ids
3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--

3 Novoseek inferred chemical compound relationships for PIGC gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
udp-n-acetylglucosamine 78.6 1 8806613 (1)
n-acetylglucosamine 76 1 8806613 (1)
phosphatidylinositol 61.9 1 8806613 (1)



PIGC for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for PIGC gene (2 alternative transcripts): 
NM_002642.3  NM_153747.1  

Unigene Cluster for PIGC:

Phosphatidylinositol glycan anchor biosynthesis, class C
Hs.188456  [show with all ESTs]
Unigene Representative Sequence: NM_002642
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000489002 ENST00000465374 ENST00000475059 ENST00000484368(uc001gii.1)
ENST00000344529 ENST00000367728(uc021pey.1) ENST00000478184 ENST00000258324(uc001gin.3 uc001gio.3)

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat PIGC using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate PIGC:
hsa-miR-2115
SwitchGear 3'UTR luciferase reporter plasmidPIGC 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for PIGC
Predesigned siRNA for gene silencing in human, mouse, rat PIGC
Clone
Products:
     
OriGene clones in human, mouse for PIGC (see all 12)
OriGene ORF clones in mouse, rat for PIGC
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): PIGC (NM_153747)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIGC
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIGC
Primer
Products:
    
OriGene qPCR primer pairs and template standards for PIGC
OriGene qSTAR qPCR primer pairs in human, mouse for PIGC
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PIGC
  QuantiTect SYBR Green Assays in human, mouse, rat PIGC
  QuantiFast Probe-based Assays in human, mouse, rat PIGC

Additional mRNA sequence: 

AK308201.1 BC006539.2 BT006734.1 CR450292.1 

7 DOTS entries:

DT.91759351  DT.444042  DT.121390224  DT.100770511  DT.91759361  DT.100832087  DT.106263 

Selected AceView cDNA sequences (see all 219):

CR602183 CR597603 AI657162 CA413594 CR619683 BC006539 CB240824 AI125856 
NM_002642 NM_153747 BX092985 AU104999 AL035301 CR610325 AV660576 AU099284 
D58610 AA505964 CR606898 CR606378 AI472007 BM839701 AI201490 BI770501 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

PIGC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTGTAACATA
PIGC Expression
About this image

PIGC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

PIGC Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.188456
    Custom PCR Arrays for PIGC
Primer
Products:
OriGene qPCR primer pairs and template standards for PIGC
OriGene qSTAR qPCR primer pairs in human, mouse for PIGC
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PIGC
QuantiTect SYBR Green Assays in human, mouse, rat PIGC
QuantiFast Probe-based Assays in human, mouse, rat PIGC
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGC

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of eukaryotes.

Orthologs for PIGC gene from Selected species (see all 19)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Pigc1 , 5 phosphatidylinositol glycan anchor biosynthesis, class more1, 5 86.53(n)1
93.6(a)1
  1 (69.95 cM)5
672921  NM_026078.21  NP_080354.11 
 1619691865 
chicken
(Gallus gallus)
Aves PIGC1 phosphatidylinositol glycan anchor biosynthesis, class more 72.52(n)
80(a)
  424387  XM_422231.4  XP_422231.2 
lizard
(Anolis carolinensis)
Reptilia PIGC6
phosphatidylinositol glycan anchor biosynthesis, c...
78(a)
1 ↔ 1
GL343959.1(81027-81926)
tropical clawed frog
(Xenopus tropicalis)
Amphibia LOC1017329031 phosphatidylinositol N-acetylglucosaminyltransferase more 71.28(n)
78.72(a)
  101732903  XM_004913731.1  XP_004913788.1 
zebrafish
(Danio rerio)
Actinopterygii pigc1 phosphatidylinositol glycan, class C 59.43(n)
55.16(a)
  323994  NM_213261.1  NP_998426.1 
fruit fly
(Drosophila melanogaster)
Insecta CG120771 CG12077 48.07(n)
38.77(a)
  38410  NM_139547.2  NP_647804.2 
worm
(Caenorhabditis elegans)
Secernentea T20D3.81 T20D3.8 48.26(n)
35.14(a)
  177765  NM_069244.1  NP_501645.1 
thale cress
(Arabidopsis thaliana)
eudicotyledons SETH11 SETH1 46.35(n)
36.5(a)
  818062  NM_129050.1  NP_181043.1 
rice
(Oryza sativa)
Liliopsida Os02g06222001 Os02g0622200 46.08(n)
34.04(a)
  4330019  NM_001054001.1  NP_001047466.1 


ENSEMBL Gene Tree for PIGC (if available)
TreeFam Gene Tree for PIGC (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for PIGC gene

PIGC for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for PIGC
PGOHUM00000242204 PGOHUM00000233522


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

1 SNPs for PIGC    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs10634121,2,4
----see VAR_0113602 mis40--------

HapMap Linkage Disequilibrium report for PIGC (172339329 - 172413230 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for PIGC: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing PIGC
DNA2.0 Custom Variant and Variant Library Synthesis for PIGC

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 601730    OMIM disorders: --

2 diseases for PIGC:    
About MalaCards
lassa fever    malaria

1 disease from the University of Copenhagen DISEASES database for PIGC:
Lassa fever

PIGC for disorders           About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: PIGC (1 document)

Export disorders for PIGC gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for PIGC gene, integrated from 10 sources (see all 19):
(articles sorted by number of sources associating them with PIGC)
    Utopia: connect your pdf to the dynamic
world of online information

  1. PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homologue of Saccharomyces cerevisiae GPI2. (PubMed id 8806613)1, 2, 3, 9 Inoue N.... Kinoshita T. (Biochem. Biophys. Res. Commun. 1996)
  2. Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1. (PubMed id 9325057)1, 2, 3, 9 Hong Y....Kinoshita T. (Genomics 1997)
  3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. (PubMed id 10944123)1, 9 Watanabe R.... Kinoshita T. (EMBO J. 2000)
  6. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
  7. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. (PubMed id 20935629)1 Heid I.M....Lindgren C.M. (Nat. Genet. 2010)
  8. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
  9. Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteins. (PubMed id 12655644)1 Eisenhaber B....Eisenhaber F. (Bioessays 2003)
  10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 5279 HGNC: 8960 AceView: PIGC Ensembl:ENSG00000135845 euGenes: HUgn5279
ECgene: PIGC Kegg: 5279 H-InvDB: PIGC

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for PIGC Pharmacogenomics, SNPs, Pathways
Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_556

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for PIGC gene:
Search GeneIP for patents involving PIGC

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PIGC  
 OriGene qPCR primer pairs and template standards for PIGC   OriGene Protein Over-expression Lysate for PIGC  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for PIGC  
 OriGene qSTAR qPCR primer pairs in human, mouse for PIGC   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for PIGC   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for PIGC   OriGene Custom Protein Services for PIGC  

 
 
 Block miRNA regulation of human, mouse, rat PIGC using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PIGC
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIGC Predesigned siRNA for gene silencing in human, mouse, rat PIGC
 QuantiFast Probe-based Assays in human, mouse, rat PIGC QuantiTect SYBR Green Assays in human, mouse, rat PIGC
 Custom PCR Arrays for PIGC Search Chromatin IP Primers for PIGC
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PIGC  GeneGlobe Interaction Network for PIGC
 Regulatory tfbs in PIGC promoter
 GenScript Custom Purified and Recombinant Proteins Services for PIGC GenScript cDNA clones with any tag delivered in your preferred vector for PIGC
 GenScript Custom Assay Services for PIGC GenScript Custom overexpressing Cell Line Services for PIGC
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for PIGC
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 cDNA Clones for PIGC
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 PIGC antibodies
 PIGC proteins
 PIGC lysates
 Antibodies for PIGC
 See all of Abcam's Antibodies, Kits and Proteins for PIGC
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for PIGC
 Antibodies for PIGC
 ELISAs for PIGC
 CLIAs for PIGC



 Browse ESI BIO Cell Lines and PureStem Progenitors for PIGC
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGC
 SwitchGear 3'UTR luciferase reporter plasmids for PIGC
 SwitchGear Promoter luciferase reporter plasmids for PIGC
 Search ThermoFisher Antibodies for PIGC
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIGC
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PIGC
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PIGC
 LSBio Antibodies in human, mouse, rat for PIGC
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      PIGC gene at Home site.
Version: 3.12.142 28 July 2014
hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4