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PIGB Gene(Protein Coding)

Phosphatidylinositol Glycan Anchor Biosynthesis Class B

GCID:
GC15P055318
GIFtS:
56
Genes Participants
UDN Logo

Aliases for PIGB Gene

Aliases for PIGB Gene

  • Phosphatidylinositol Glycan Anchor Biosynthesis Class B 2 3 5
  • Phosphatidylinositol-Glycan Biosynthesis Class B Protein 3 4
  • Dol-P-Man Dependent GPI Mannosyltransferase 2 3
  • Phosphatidylinositol Glycan, Class B 2 3
  • GPI Mannosyltransferase III 3 4
  • GPI Mannosyltransferase 3 2 3
  • GPI-MT-III 3 4
  • PIG-B 3 4
  • EC 2.4.1.- 4
  • EC 2.4.1 61

External Ids for PIGB Gene

Previous GeneCards Identifiers for PIGB Gene

  • GC15P051169
  • GC15P048658
  • GC15P053190
  • GC15P053327
  • GC15P053398
  • GC15P055611
  • GC15P032437

Summaries for PIGB Gene

Entrez Gene Summary for PIGB Gene

  • This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene is thought to encode a member of a family of dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases. [provided by RefSeq, Jul 2008]

GeneCards Summary for PIGB Gene

PIGB (Phosphatidylinositol Glycan Anchor Biosynthesis Class B) is a Protein Coding gene. Among its related pathways are Glycosylphosphatidylinositol (GPI)-anchor biosynthesis and Metabolism of proteins. GO annotations related to this gene include transferase activity, transferring glycosyl groups and mannosyltransferase activity.

UniProtKB/Swiss-Prot for PIGB Gene

  • Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.

Gene Wiki entry for PIGB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIGB Gene

Genomics for PIGB Gene

Products:

  1. Regulatory Element

Regulatory Elements for PIGB Gene

Enhancers for PIGB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F055317 1.1 ENCODE 48.2 +0.4 388 3.0 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 CBX5 PIGB PIGBOS1 DYX1C1 ENSG00000274765
GH15F055275 1.3 FANTOM5 ENCODE 33 -37.7 -37696 10.4 HDGF PKNOX1 ATF1 ARNT WRNIP1 SIN3A BRCA1 GATA2 CBX5 FOS PIGB RSL24D1 RAB27A GC15P055286 GC15M056100
GH15F055194 1.4 FANTOM5 ENCODE 24.1 -122.3 -122254 3.4 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 PIGB RSL24D1 PIGBOS1 RAB27A C15orf65 ENSG00000279145
GH15F055265 1.4 FANTOM5 Ensembl ENCODE 16.8 -51.3 -51338 4.6 BCOR LEF1 JUN ZMYM3 ZNF316 ZNF366 SCRT2 NFE2 FOS TCF7L2 PIGB RAB27A DYX1C1 GC15P055286 GC15M056100
GH15F055322 0.6 Ensembl ENCODE 34.5 +4.5 4536 2.0 SPI1 PIGB PIGBOS1 ENSG00000274765
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PIGB on UCSC Golden Path with GeneCards custom track

Promoters for PIGB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001452345 335 2801 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 CBX5

Transcription factor binding sites by QIAGEN in the PIGB gene promoter:

Genomic Location for PIGB Gene

Chromosome:
15
Start:
55,318,865 bp from pter
End:
55,355,648 bp from pter
Size:
36,784 bases
Orientation:
Plus strand

Genomic View for PIGB Gene

Genes around PIGB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIGB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIGB Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PIGB Gene

Proteins for PIGB Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for PIGB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92521-PIGB_HUMAN
    Recommended name:
    GPI mannosyltransferase 3
    Protein Accession:
    Q92521
    Secondary Accessions:
    • Q53FF9
    • Q8WVN7

    Protein attributes for PIGB Gene

    Size:
    554 amino acids
    Molecular mass:
    65056 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PIGB Gene

Protein Expression for PIGB Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for PIGB Gene

Q92521:
  • DEYWQSLE
  • YYPLEGS
  • HKEFRFIYPVLPFCM
  • FYGSHPWHWY
  • THLPFFIHGC
  • MPCHSTP
  • TRTLTNTME

Post-translational modifications for PIGB Gene

  • Glycosylation at Asn 26 and Asn 427
  • Modification sites at PhosphoSitePlus

Other Protein References for PIGB Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PIGB Gene

Gene Families for PIGB Gene

HGNC:

Protein Domains for PIGB Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PIGB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92521

UniProtKB/Swiss-Prot:

PIGB_HUMAN :
  • Belongs to the glycosyltransferase 22 family. PIGB subfamily.
Family:
  • Belongs to the glycosyltransferase 22 family. PIGB subfamily.
genes like me logo Genes that share domains with PIGB: view

Function for PIGB Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for PIGB Gene

GENATLAS Biochemistry:
glycosyl-phosphatidylinositol (GPI) anchor synthesis,class B
UniProtKB/Swiss-Prot Function:
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.

Enzyme Numbers (IUBMB) for PIGB Gene

Gene Ontology (GO) - Molecular Function for PIGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000030 mannosyltransferase activity IDA 8861954
GO:0004376 glycolipid mannosyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with PIGB: view
genes like me logo Genes that share phenotypes with PIGB: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PIGB

miRNA for PIGB Gene

miRTarBase miRNAs that target PIGB

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIGB Gene

Localization for PIGB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIGB Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIGB gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
peroxisome 3
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for PIGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,NAS 8861954
genes like me logo Genes that share ontologies with PIGB: view

Pathways & Interactions for PIGB Gene

genes like me logo Genes that share pathways with PIGB: view

UniProtKB/Swiss-Prot Q92521-PIGB_HUMAN

  • Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.

Gene Ontology (GO) - Biological Process for PIGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006506 GPI anchor biosynthetic process IEA,IDA 8861954
GO:0016254 preassembly of GPI anchor in ER membrane TAS --
GO:0097502 mannosylation IEA --
genes like me logo Genes that share ontologies with PIGB: view

No data available for SIGNOR curated interactions for PIGB Gene

Drugs & Compounds for PIGB Gene

Products:

  1. Drug

(3) Drugs for PIGB Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
Sphingosine-1-phosphate Pharma Full agonist, Agonist endogenous second messenger and ligand for S1PR1, Endogenous agonist at S1P1-5 0

(841) Additional Compounds for PIGB Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Dehydrosphinganine
  • (2S)-2-amino-1-hydroxyoctadecan-3-one
  • 1-Hydroxy-2-amino-3-oxo-octadecane
  • 2-Amino-1-hydroxy-3-Octadecanone
  • 3-Dehydro-D-sphinganine
  • 3-Dehydrosphinganine
 16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
 852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
 862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
 244215-65-4
genes like me logo Genes that share compounds with PIGB: view

Transcripts for PIGB Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for PIGB Gene

(8) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(68) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PIGB Gene

Phosphatidylinositol glycan anchor biosynthesis, class B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIGB Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14
SP1: -
SP2: -
SP3: -
SP4: - - - -
SP5:
SP6:
SP7:

Relevant External Links for PIGB Gene

GeneLoc Exon Structure for
PIGB
ECgene alternative splicing isoforms for
PIGB

Expression for PIGB Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PIGB Gene

mRNA expression in normal human tissues for PIGB Gene
mRNA expression by BioGPS for PIGB GenemRNA expression by GTEx for PIGB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PIGB Gene

This gene is overexpressed in Testis (42.6) and Placenta (22.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PIGB Gene



Protein tissue co-expression partners for PIGB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PIGB Gene:

PIGB

SOURCE GeneReport for Unigene cluster for PIGB Gene:

Hs.612814
genes like me logo Genes that share expression patterns with PIGB: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PIGB Gene

Orthologs for PIGB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PIGB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia PIGB 34 35
  • 99.58 (n)
cow
(Bos Taurus)
 Mammalia PIGB 34 35
  • 89.78 (n)
dog
(Canis familiaris)
 Mammalia PIGB 34 35
  • 89.4 (n)
rat
(Rattus norvegicus)
 Mammalia Pigb 34
  • 80.48 (n)
mouse
(Mus musculus)
 Mammalia Pigb 34 16 35
  • 78.82 (n)
oppossum
(Monodelphis domestica)
 Mammalia PIGB 35
  • 78 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia PIGB 35
  • 72 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves PIGB 34 35
  • 69.83 (n)
lizard
(Anolis carolinensis)
 Reptilia PIGB 35
  • 53 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia pigb 34
  • 67.51 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.10358 34
zebrafish
(Danio rerio)
 Actinopterygii pigb 34 35
  • 58.54 (n)
zgc63658 34
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP003792 34
  • 49.86 (n)
fruit fly
(Drosophila melanogaster)
 Insecta CG12006 36 34 35
  • 48.95 (n)
worm
(Caenorhabditis elegans)
 Secernentea T27F7.3a 36
  • 36 (a)
T27F7.4 35
  • 33 (a)
 OneToOne
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes GPI10 35 37
  • 25 (a)
 OneToOne
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT5G14850 34
  • 51.39 (n)
rice
(Oryza sativa)
 Liliopsida Os01g0580100 34
  • 49.56 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 40 (a)
 OneToOne
Species where no ortholog for PIGB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIGB Gene

ENSEMBL:
Gene Tree for PIGB (if available)
TreeFam:
Gene Tree for PIGB (if available)

Paralogs for PIGB Gene

No data available for Paralogs for PIGB Gene

Variants for PIGB Gene

Sequence variations from dbSNP and Humsavar for PIGB Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10563845 -- 55,327,220(+) TATAA(-/AT)ATATA intron-variant
rs10851588 -- 55,330,392(+) GGCTG(A/G)AGGAG intron-variant
rs11071180 -- 55,330,101(+) CCATA(A/G)TACCC intron-variant
rs11071181 -- 55,330,328(+) GAAAG(C/G)AAGGT intron-variant
rs11071182 -- 55,352,478(+) GAGCC(A/G)GATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIGB Gene

Variant ID Type Subtype PubMed ID
nsv569524 CNV loss 21841781
nsv569523 CNV gain 21841781
nsv520799 CNV loss 19592680
nsv1043789 CNV gain 25217958
nsv1036924 CNV loss 25217958
esv3569598 CNV gain 25503493
esv3333010 CNV insertion 20981092
esv2761899 CNV gain+loss 21179565

Variation tolerance for PIGB Gene

Residual Variation Intolerance Score: 71.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.27; 85.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIGB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIGB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIGB Gene

Disorders for PIGB Gene

Relevant External Links for PIGB

Genetic Association Database (GAD)
PIGB
Human Genome Epidemiology (HuGE) Navigator
PIGB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIGB

No disorders were found for PIGB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIGB Gene

Publications for PIGB Gene

  1. PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor. (PMID: 8861954) Takahashi M. … Kinoshita T. (EMBO J. 1996) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Glycoinositol phospholipid anchor-defective K562 mutants with biochemical lesions distinct from those in Thy-1- murine lymphoma mutants. (PMID: 7907094) Mohney R.P. … Medof M.E. (J. Biol. Chem. 1994) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for PIGB Gene

Sources for PIGB Gene

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