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PIGB Gene

protein-coding   GIFtS: 63
GCID: GC15P055611

Phosphatidylinositol Glycan Anchor Biosynthesis, Class B

(Previous names: phosphatidylinositol glycan, class B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phosphatidylinositol Glycan Anchor Biosynthesis, Class B1 2     GPI-MT-III2 3
Phosphatidylinositol Glycan, Class B1 2     PIG-B2 3
Dol-P-Man Dependent GPI Mannosyltransferase1 2     GPI Mannosyltransferase III2 3
GPI Mannosyltransferase 31 2     EC 2.4.1.-3
Phosphatidylinositol-Glycan Biosynthesis Class B Protein2 3     EC 2.4.18

External Ids:    HGNC: 89591   Entrez Gene: 94882   Ensembl: ENSG000000699437   OMIM: 6041225   UniProtKB: Q925213   

Export aliases for PIGB gene to outside databases

Previous GC identifers: GC15P051169 GC15P048658 GC15P053190 GC15P053327 GC15P053398 GC15P032437


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PIGB Gene:
This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in
GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells
and serves to anchor proteins to the cell surface. This gene is thought to encode a member of a family of
dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases. (provided by RefSeq, Jul 2008)

GeneCards Summary for PIGB Gene:
PIGB (phosphatidylinositol glycan anchor biosynthesis, class B) is a protein-coding gene. Diseases associated with PIGB include encephalomalacia, and griscelli syndrome. GO annotations related to this gene include mannosyltransferase activity.

UniProtKB/Swiss-Prot: PIGB_HUMAN, Q92521
Function: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third
alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly

Gene Wiki entry for PIGB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PIGB gene promoter:
         C/EBPbeta   RelA   STAT5A   NRSF form 2   c-Rel   Zic1   FOXO1a   ZID   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIGB promoter sequence
   Search Chromatin IP Primers for PIGB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIGB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.3   Ensembl cytogenetic band:  15q21.3   HGNC cytogenetic band: 15q21.3

PIGB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIGB gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P055611:  view genomic region     (about GC identifiers)

Start:
55,611,133 bp from pter      End:
55,647,846 bp from pter
Size:
36,714 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PIGB_HUMAN, Q92521 (See protein sequence)
Recommended Name: GPI mannosyltransferase 3  
Size: 554 amino acids; 65056 Da
Secondary accessions: Q53FF9 Q8WVN7

Explore the universe of human proteins at neXtProt for PIGB: NX_Q92521

Explore proteomics data for PIGB at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn26, Asn427
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PIGB (Q92521) (see all 7)
     MPCHSTP  YYPLEGS  DEYWQSLE  TRTLTNTME 


    See PIGB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004846.4  
    ENSEMBL proteins: 
     ENSP00000455943   ENSP00000164305   ENSP00000456285   ENSP00000456531   ENSP00000455040  
     ENSP00000438963  
    Reactome Protein details: Q92521

    PIGB Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DOLPM: Dolichyl D-mannosyl phosphate dependent mannosyltransferases
    PIG: Phosphatidylinositol glycan anchor biosynthesis

    1 InterPro protein domain:
     IPR005599 GPI_mannosylTrfase

    Graphical View of Domain Structure for InterPro Entry Q92521

    ProtoNet protein and cluster: Q92521

    1 Blocks protein domain: IPB005599 Plasmid Maintenance Protein

    UniProtKB/Swiss-Prot: PIGB_HUMAN, Q92521
    Similarity: Belongs to the glycosyltransferase 22 family. PIGB subfamily


    PIGB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIGB_HUMAN, Q92521
    Function: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third
    alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly

         Genatlas biochemistry entry for PIGB:
    glycosyl-phosphatidylinositol (GPI) anchor synthesis,class B

         Enzyme Numbers (IUBMB): EC 2.4.12 EC 2.4.1.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000030mannosyltransferase activity IDA8861954
    GO:0016757transferase activity, transferring glycosyl groups ----
         
    PIGB for ontologies           About GeneDecksing


    Animal Models:
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    hsa-mir-149-5p (MIRT045396), hsa-mir-375 (MIRT019704), hsa-mir-9-5p (MIRT021352)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PIGB_HUMAN, Q92521: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    peroxisome3
    plasma membrane3
    cytosol1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane NAS8861954

    PIGB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PIGB About    
    See pathways by source

    SuperPathContained pathways About
    1Post-translational modification- synthesis of GPI-anchored proteins
    Post-translational modification- synthesis of GPI-anchored proteins0.76
    Synthesis of glycosylphosphatidylinositol (GPI)0.00
    Glycosylphosphatidylinositol(GPI)-anchor biosynthesis0.76
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30
    3Metabolism
    Metabolic pathways0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for PIGB
        Synthesis of glycosylphosphatidylinositol (GPI)


    2 Kegg Pathways  (Kegg details for PIGB):
        Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: PIGB_HUMAN, Q92521
    Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis


    PIGB for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PIGB
    Interactions:

        Search GeneGlobe Interaction Network for PIGB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for PIGB (Q925213 ENSP000001643054) via UniProtKB, MINT, STRING, and/or I2D (see all 22)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TMED10P497553, ENSP000003031454I2D: score=4 STRING: ENSP00000303145
    CDC40O605083, ENSP000003043704I2D: score=1 STRING: ENSP00000304370
    DNAJA1P316893I2D: score=1 
    EEF1A1P681043I2D: score=1 
    FNBP1LQ5T0N53I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006501C-terminal protein lipidation TAS--
    GO:0006506GPI anchor biosynthetic process IDA8861954
    GO:0016254preassembly of GPI anchor in ER membrane TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    PIGB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PIGB

    Selected HMDB Compounds for PIGB (see all 898)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
    3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
    3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
    3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
    3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
    3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
    3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PIGB gene: 
    NM_004855.4  

    Unigene Cluster for PIGB:

    Phosphatidylinositol glycan anchor biosynthesis, class B
    Hs.612814  [show with all ESTs]
    Unigene Representative Sequence: NM_004855
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000565367 ENST00000164305(uc002act.3 uc010ugg.2) ENST00000569909
    ENST00000570059 ENST00000566999 ENST00000566072 ENST00000565402 ENST00000565502
    ENST00000563742 ENST00000569823 ENST00000562751 ENST00000539642
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    Additional mRNA sequence: 

    AK223330.1 AK293666.1 AK314706.1 BC017711.1 D42138.1 

    14 DOTS entries:

    DT.444271  DT.75103232  DT.95171373  DT.91737729  DT.95171371  DT.318391  DT.100787663  DT.318388 
    DT.121055554  DT.318389  DT.91722232  DT.91922208  DT.97789971  DT.95144894 

    Selected AceView cDNA sequences (see all 68):

    N51160 D42138 AF052498 CB215160 CR591869 AW175964 NM_004855 AA644686 
    BX432985 BQ271124 BM966989 BQ436473 BI222368 AA461248 BP369083 BX282468 
    AA385310 CA444909 BX447668 AA425409 BG032581 BX430889 AI913301 AU138280 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PIGB (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14
    SP1:                                                                    -                                             
    SP2:                                                                    -                                             
    SP3:              -                                                                                                   
    SP4:              -     -     -           -                                                                           
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for PIGB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PIGB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAATACAAT
    PIGB Expression
    About this image


    PIGB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
    PIGB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIGB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.612814
        Custom PCR Arrays for PIGB
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PIGB gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pigb1 , 5 phosphatidylinositol glycan anchor biosynthesis, class more1, 5 78.82(n)1
    80.75(a)1
      9 (40.08 cM)5
    559811  NM_018889.31  NP_061377.21 
     730074195 
    chicken
    (Gallus gallus)
    Aves PIGB1 phosphatidylinositol glycan anchor biosynthesis, class more 69.83(n)
    70.52(a)
      100858627  XM_003641880.2  XP_003641928.2 
    lizard
    (Anolis carolinensis)
    Reptilia PIGB6
    phosphatidylinositol glycan anchor biosynthesis, c...
    53(a)
    1 ↔ 1
    AAWZ02037309(16069-17346)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.103582 Xenopus laevis transcribed sequence with weak similarity more 77.58(n)    CA973249.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc636582 hypothetical protein MGC63658 72.89(n)   393448  BC055191.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG120061 , 3 CG120061 40(a)3
    48.95(n)1
    43.25(a)1
      63F13
    384461  NM_206269.31  NP_995991.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T27F7.3a3   -- 36(a)   II(4991576-4993066)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GPI10(YGL142C)4 Integral membrane protein involved in glycosylphosphatidylinositol more   --   7(238119-236269) 852735  NP_011373.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G148501 AT5G14850 51.39(n)
    42.5(a)
      831337  NM_121489.1  NP_568305.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g05801001 Os01g0580100 49.56(n)
    42.57(a)
      4324190  NM_001049939.1  NP_001043404.1 


    ENSEMBL Gene Tree for PIGB (if available)
    TreeFam Gene Tree for PIGB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PIGB (see all 766)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1169185501,2
    C,F--32435063(+) GTAACG/AGAGTG 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs672295531,2
    C--35683787(+) AAAAA-/AC/CA 
            
    AGTCA
    1 -- int10--------
    rs287059231,2
    C--55609293(+) AAATAC/TTCACT 1 -- us2k10--------
    rs734155321,2
    C,F--55609310(+) TAAAAG/TGAAAT 1 -- us2k17Minor allele frequency- T:0.20WA CSA NA EA 365
    rs1807741341,2
    --55609328(+) CTGTCC/TTGGTA 1 -- us2k10--------
    rs351261911,2
    C--55609388(+) AGGTT-/AAAAAA 1 -- us2k10--------
    rs344736091,2
    C,F--55609565(+) TGGAGT/GGCAGC 1 -- us2k13Minor allele frequency- G:0.33NA 6
    rs1861295751,2
    --55609590(+) TCACTC/GCCACC 1 -- us2k10--------
    rs1905902331,2
    C--55609621(+) GATGCC/TCCTGC 1 -- us2k10--------
    rs286850051,2
    C,F--55609692(+) ATTTTT/CAGTAG 1 -- us2k16Minor allele frequency- C:0.30NA WA CSA 10

    HapMap Linkage Disequilibrium report for PIGB (55611133 - 55647846 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PIGB:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv267383CNV Insertion20981092
    nsv904243CNV Loss21882294
    nsv520799CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604122    OMIM disorders: --

    4 diseases for PIGB:    
    About MalaCards
    encephalomalacia    griscelli syndrome    sleeping sickness    malaria


    PIGB for disorders           About GeneDecksing

    Genetic Association Database (GAD): PIGB
    Human Genome Epidemiology (HuGE) Navigator: PIGB (1 document)

    Export disorders for PIGB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIGB gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with PIGB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor. (PubMed id 8861954)1, 2, 3, 9 Takahashi M.... Kinoshita T. (EMBO J. 1996)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Glycoinositol phospholipid anchor-defective K562 mutants with biochemical lesions distinct from those in Thy-1- murine lymphoma mutants. (PubMed id 7907094)1, 2 Mohney R.P.... Medof M.E. (J. Biol. Chem. 1994)
    5. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    6. siRNA-mediated inhibition of phosphatidylinositol glycan Class B (PIGB) confers resistance to methylmercury in HEK293 cells. (PubMed id 18198489)1 Hwang G.W....Naganuma A. (J Toxicol Sci 2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Evidence that Griscelli syndrome with neurological involvement is caused by mutations in RAB27A, not MYO5A. (PubMed id 12058346)1 Anikster Y.... Hurvitz H. (Am. J. Hum. Genet. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9488 HGNC: 8959 AceView: PIGB Ensembl:ENSG00000069943 euGenes: HUgn9488
    ECgene: PIGB Kegg: 9488 H-InvDB: PIGB

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PIGB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PIGB gene:
    Search GeneIP for patents involving PIGB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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