PIGB Gene

Aliases
for PIGB gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC15P051169 GC15P048658 GC15P053190 GC15P053327 GC15P053398 GC15P032437

Summaries
for PIGB gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for PIGB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000015.9  NT_010194.18  NC_018926.2  

SwitchGear Promoter luciferase reporter plasmid: PIGB promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIGB

PIGB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P055611:  view genomic region     (about GC identifiers)

Proteins
for PIGB gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for PIGB: NX_Q92521

Explore proteomics data for PIGB at MOPED

Post-translational modifications: 

PIGB Human Recombinant Protein Products:

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Domains /
Families
for PIGB gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q92521

Find genes that share domains with PIGB           About GenesLikeMe

Function
for PIGB gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for PIGB

miRNA Products:		miRTarBase miRNAs that target PIGB: hsa-mir-149-5p (MIRT045396), hsa-mir-375 (MIRT019704), hsa-mir-9-5p (MIRT021352)
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Gene Editing Products:

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGB

Localization
for PIGB gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
endoplasmic reticulum	5
peroxisome	3
plasma membrane	3
cytosol	1
nucleus	1

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for PIGB gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for PIGB About     See pathways by source

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	SuperPath	Contained pathways About
1	Post-translational modification- synthesis of GPI-anchored proteins	Post-translational modification- synthesis of GPI-anchored proteins 0.76 Synthesis of glycosylphosphatidylinositol (GPI) 0.00 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis 0.76
2	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	Post-translational protein modification 0.43 Metabolism of proteins 0.30
3	Metabolism	Metabolic pathways 0.38

1 Reactome Pathway for PIGB

Synthesis of glycosylphosphatidylinositol (GPI)

2 Kegg Pathways  (Kegg details for PIGB)

	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
	Metabolic pathways

    Custom Pathway & Disease-focused RT² Profiler PCR Arrays for PIGB
Interactions:

    Search GeneGlobe Interaction Network for PIGB

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

Selected Interacting proteins for PIGB (Q92521³ ENSP00000164305⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 22)

Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

Drugs & Compounds
for PIGB gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for PIGB gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for PIGB gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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PIGB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTAATACAAT

About this image

Blood (Hematopoietic System)    fully expand to see all 2 entries
Monocytes Peripheral Blood

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGB

Orthologs
for PIGB gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for PIGB gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Genomic Variants
for PIGB gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for PIGB (see all 766)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1169185501,2	C,F	--	32435063(+)	GTAACG/AGAGTG	1	--	us2k1		1		NA	120
rs672295531,2	C	--	35683787(+)	AAAAA-/AC/CA          AGTCA	1	--	int1		0	--	--	--	--
rs287059231,2	C	--	55609293(+)	AAATAC/TTCACT	1	--	us2k1		0	--	--	--	--
rs734155321,2	C,F	--	55609310(+)	TAAAAG/TGAAAT	1	--	us2k1		7		WA CSA NA EA	365
rs1807741341,2		--	55609328(+)	CTGTCC/TTGGTA	1	--	us2k1		0	--	--	--	--
rs351261911,2	C	--	55609388(+)	AGGTT-/AAAAAA	1	--	us2k1		0	--	--	--	--
rs344736091,2	C,F	--	55609565(+)	TGGAGT/GGCAGC	1	--	us2k1		3		NA	6
rs1861295751,2		--	55609590(+)	TCACTC/GCCACC	1	--	us2k1		0	--	--	--	--
rs1905902331,2	C	--	55609621(+)	GATGCC/TCCTGC	1	--	us2k1		0	--	--	--	--
rs286850051,2	C,F	--	55609692(+)	ATTTTT/CAGTAG	1	--	us2k1		6		NA WA CSA	10

HapMap Linkage Disequilibrium report for PIGB (55611133 - 55647846 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for PIGB:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv267383	CNV	Insertion	20981092
nsv904243	CNV	Loss	21882294
nsv520799	CNV	Loss	19592680

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing PIGB

DNA2.0 Custom Variant and Variant Library Synthesis for PIGB

Disorders / Diseases
for PIGB gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for PIGB gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor. (PubMed id 8861954)^{1, 2, 3, 9} Takahashi M.... Kinoshita T. (EMBO J. 1996)
2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
4. Glycoinositol phospholipid anchor-defective K562 mutants with biochemical lesions distinct from those in Thy-1- murine lymphoma mutants. (PubMed id 7907094)^{1, 2} Mohney R.P.... Medof M.E. (J. Biol. Chem. 1994)
5. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)¹ Emanuele M.J....Elledge S.J. (Cell 2011)
6. siRNA-mediated inhibition of phosphatidylinositol glycan Class B (PIGB) confers resistance to methylmercury in HEK293 cells. (PubMed id 18198489)¹ Hwang G.W....Naganuma A. (J Toxicol Sci 2007)
7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (Genome Res. 2006)
8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (Nat. Genet. 2004)
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
10. Evidence that Griscelli syndrome with neurological involvement is caused by mutations in RAB27A, not MYO5A. (PubMed id 12058346)¹ Anikster Y.... Hurvitz H. (Am. J. Hum. Genet. 2002)

External Searches for PIGB gene

Genome Databases showing PIGB gene

Other Databases showing PIGB gene

Specialized Databases showing PIGB gene

Products
for PIGB gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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