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PIGB Gene

protein-coding GIFtS: 63
GCID: GC15P055611

Phosphatidylinositol Glycan Anchor Biosynthesis, Class B

(Previous names: phosphatidylinositol glycan, class B)

See PIGB-related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Phosphatidylinositol Glycan Anchor Biosynthesis, Class B¹ ²		GPI-MT-III² ³
Phosphatidylinositol Glycan, Class B¹ ²		PIG-B² ³
Dol-P-Man Dependent GPI Mannosyltransferase¹ ²		GPI Mannosyltransferase III² ³
GPI Mannosyltransferase 3¹ ²		EC 2.4.1.-³
Phosphatidylinositol-Glycan Biosynthesis Class B Protein² ³		EC 2.4.1⁸

External Ids:	HGNC: 8959¹	Entrez Gene: 9488²	Ensembl: ENSG00000069943⁷	OMIM: 604122⁵	UniProtKB: Q92521³

Export aliases for PIGB gene to outside databases

Previous GC identifers: GC15P051169 GC15P048658 GC15P053190 GC15P053327 GC15P053398 GC15P032437

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PIGB Gene:

This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in

GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells

and serves to anchor proteins to the cell surface. This gene is thought to encode a member of a family of

dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases. (provided by RefSeq, Jul 2008)

GeneCards Summary for PIGB Gene:

PIGB (phosphatidylinositol glycan anchor biosynthesis, class B) is a protein-coding gene. Diseases associated with PIGB include griscelli syndrome. GO annotations related to this gene include mannosyltransferase activity.

UniProtKB/Swiss-Prot: PIGB_HUMAN, Q92521

Function: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third

alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly

Gene Wiki entry for PIGB Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000015.9 NT_010194.18 NC_018926.2

Regulatory elements:

Regulatory transcription factor binding sites in the PIGB gene promoter:
C/EBPbeta RelA STAT5A NRSF form 2 c-Rel Zic1 FOXO1a ZID FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PIGB promoter sequence

Search Chromatin IP Primers for PIGB

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIGB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.3 Ensembl cytogenetic band: 15q21.3 HGNC cytogenetic band: 15q21.3

PIGB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIGB gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P055611: view genomic region (about GC identifiers)

Start:	55,611,133 bp from pter	End:	55,647,846 bp from pter
Size:	36,714 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PIGB_HUMAN, Q92521 (See protein sequence)

Recommended Name: GPI mannosyltransferase 3

Size: 554 amino acids; 65056 Da

Secondary accessions: Q53FF9 Q8WVN7

Explore the universe of human proteins at neXtProt for PIGB: NX_Q92521

Explore proteomics data for PIGB at MOPED

Post-translational modifications:

Glycosylation² at Asn26, Asn427

Modification sites at PhosphoSitePlus

Selected DME Specific Peptides for PIGB (Q92521) (see all 7)

MPCHSTP

YYPLEGS

DEYWQSLE

TRTLTNTME

See PIGB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_004846.4

ENSEMBL proteins:

ENSP00000455943 ENSP00000164305 ENSP00000456285 ENSP00000456531 ENSP00000455040

ENSP00000438963

Reactome Protein details: Q92521

PIGB Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

DOLPM: Dolichyl D-mannosyl phosphate dependent mannosyltransferases

PIG: Phosphatidylinositol glycan anchor biosynthesis

1 InterPro protein domain:

IPR005599 GPI_mannosylTrfase

Graphical View of Domain Structure for InterPro Entry Q92521

ProtoNet protein and cluster: Q92521

1 Blocks protein domain: IPB005599 Plasmid Maintenance Protein

UniProtKB/Swiss-Prot: PIGB_HUMAN, Q92521

Similarity: Belongs to the glycosyltransferase 22 family. PIGB subfamily

Find genes that share domains with PIGB About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: PIGB_HUMAN, Q92521

Function: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third

alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly

Genatlas biochemistry entry for PIGB:

glycosyl-phosphatidylinositol (GPI) anchor synthesis,class B

Enzyme Numbers (IUBMB): EC 2.4.1² EC 2.4.1.-¹

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000030	mannosyltransferase activity	IDA	8861954
GO:0016757	transferase activity, transferring glycosyl groups	--	--

Find genes that share ontologies with PIGB About GenesLikeMe

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for PIGB

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Gene Editing
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGB

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

PIGB_HUMAN, Q92521: Endoplasmic reticulum membrane; Multi-pass membrane protein

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
endoplasmic reticulum	5
peroxisome	3
plasma membrane	3
cytosol	1
nucleus	1

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Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0016021	integral component of membrane	NAS	8861954

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for PIGB About

See pathways by source

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SuperPath

Contained pathways About

Post-translational modification- synthesis of GPI-anchored proteins

	Post-translational modification- synthesis of GPI-anchored proteins	0.76			Synthesis of glycosylphosphatidylinositol (GPI)	0.00
	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis	0.76

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

Post-translational protein modification

0.43

Metabolism of proteins

0.30

Metabolism

Metabolic pathways

0.38

Find genes that share SuperPaths with PIGB About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 Reactome Pathway for PIGB

Synthesis of glycosylphosphatidylinositol (GPI)

2 Kegg Pathways (Kegg details for PIGB):

	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
	Metabolic pathways

UniProtKB/Swiss-Prot: PIGB_HUMAN, Q92521

Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for PIGB
Interactions:

Search GeneGlobe Interaction Network for PIGB

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

Selected Interacting proteins for PIGB (Q92521³ ENSP00000164305⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 22)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TMED10	P49755³, ENSP00000303145⁴	I2D: score=4 STRING: ENSP00000303145
CDC40	O60508³, ENSP00000304370⁴	I2D: score=1 STRING: ENSP00000304370
DNAJA1	P31689³	I2D: score=1
EEF1A1	P68104³	I2D: score=1
FNBP1L	Q5T0N5³	I2D: score=1

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Gene Ontology (GO): Selected biological process terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006501	C-terminal protein lipidation	TAS	--
GO:0006506	GPI anchor biosynthetic process	IDA	8861954
GO:0016254	preassembly of GPI anchor in ER membrane	TAS	--
GO:0043687	post-translational protein modification	TAS	--
GO:0044267	cellular protein metabolic process	TAS	--

Find genes that share ontologies with PIGB About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for PIGB

Selected HMDB Compounds for PIGB (see all 898) About this table

Compound	Synonyms	CAS #	PubMed Ids
3-Dehydrosphinganine	1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)	16105-69-4	--
3-O-Sulfogalactosylceramide (d18:1/12:0)	Sulfatide (d18:1/12:0) (see all 13)	852100-88-0	--
3-O-Sulfogalactosylceramide (d18:1/14:0)	Sulfatide (d18:1/14:0) (see all 13)	--	--
3-O-Sulfogalactosylceramide (d18:1/16:0)	Sulfatide (d18:1/16:0) (see all 13)	862509-48-6	--
3-O-Sulfogalactosylceramide (d18:1/18:0)	Sulfatide (d18:1/18:0) (see all 13)	244215-65-4	--
3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))	Sulfatide (d18:1/18:1(9Z)) (see all 13)	--	--
3-O-Sulfogalactosylceramide (d18:1/20:0)	Sulfatide (d18:1/20:0) (see all 13)	265096-81-9	--
3-O-Sulfogalactosylceramide (d18:1/22:0)	Sulfatide (d18:1/22:0) (see all 13)	265096-83-1	--
3-O-Sulfogalactosylceramide (d18:1/24:0)	Sulfatide (d18:1/24:0) (see all 16)	151122-71-3	--
3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))	Sulfatide (d18:1/24:1(15Z)) (see all 13)	151057-28-2	--

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for PIGB gene:

NM_004855.4

Unigene Cluster for PIGB:

Phosphatidylinositol glycan anchor biosynthesis, class B

Hs.612814 [show with all ESTs]

Unigene Representative Sequence: NM_004855

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000565367 ENST00000164305(uc002act.3 uc010ugg.2) ENST00000569909

ENST00000570059 ENST00000566999 ENST00000566072 ENST00000565402 ENST00000565502

ENST00000563742 ENST00000569823 ENST00000562751 ENST00000539642

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Additional mRNA sequence:

AK223330.1 AK293666.1 AK314706.1 BC017711.1 D42138.1

14 DOTS entries:

DT.444271 DT.75103232 DT.95171373 DT.91737729 DT.95171371 DT.318391 DT.100787663 DT.318388

DT.121055554 DT.318389 DT.91722232 DT.91922208 DT.97789971 DT.95144894

Selected AceView cDNA sequences (see all 68):

N51160 D42138 AF052498 CB215160 CR591869 AW175964 NM_004855 AA644686

BX432985 BQ271124 BM966989 BQ436473 BI222368 AA461248 BP369083 BX282468

AA385310 CA444909 BX447668 AA425409 BG032581 BX430889 AI913301 AU138280

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for PIGB (see all 7) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13a	·	13b	^	14
SP1:																							-
SP2:																							-
SP3:					-
SP4:					-		-		-				-
SP5:

ECgene alternative splicing isoforms for PIGB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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PIGB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTAATACAAT

About this image

PIGB expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database


Blood (Hematopoietic System) fully expand to see all 2 entries
Monocytes Peripheral Blood

PIGB Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

PIGB Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.612814

Custom PCR Arrays for PIGB

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for PIGB gene from Selected species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pigb^{1 , 5}	phosphatidylinositol glycan anchor biosynthesis, class more^{1, 5}	78.82(n)¹ 80.75(a)¹		9 (40.08 cM)⁵ 55981¹ NM_018889.3¹ NP_061377.2¹ 73007419⁵
chicken (Gallus gallus)	Aves	PIGB¹	phosphatidylinositol glycan anchor biosynthesis, class more	69.83(n) 70.52(a)		100858627 XM_003641880.2 XP_003641928.2
lizard (Anolis carolinensis)	Reptilia	PIGB⁶	phosphatidylinositol glycan anchor biosynthesis, c...	53(a)	1 ↔ 1	AAWZ02037309(16069-17346)
African clawed frog (Xenopus laevis)	Amphibia	Xl.10358²	Xenopus laevis transcribed sequence with weak similarity more	77.58(n)		CA973249.1
zebrafish (Danio rerio)	Actinopterygii	zgc63658²	hypothetical protein MGC63658	72.89(n)		393448 BC055191.1
fruit fly (Drosophila melanogaster)	Insecta	CG12006^{1 , 3}	CG12006¹	40(a)³ 48.95(n)¹ 43.25(a)¹		63F1³ 38446¹ NM_206269.3¹ NP_995991.1¹
worm (Caenorhabditis elegans)	Secernentea	T27F7.3a³	--	36(a)		II(4991576-4993066) --
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	GPI10(YGL142C)⁴	Integral membrane protein involved in glycosylphosphatidylinositol more	--		7(238119-236269) 852735 NP_011373.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G14850¹	AT5G14850	51.39(n) 42.5(a)		831337 NM_121489.1 NP_568305.1
rice (Oryza sativa)	Liliopsida	Os01g0580100¹	Os01g0580100	49.56(n) 42.57(a)		4324190 NM_001049939.1 NP_001043404.1

ENSEMBL Gene Tree for PIGB (if available)
TreeFam Gene Tree for PIGB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs116918550^1,2	C,F	--	32435063(+)	`GTAACG/AGAGTG`	1	--	us2k¹		1		NA	120
rs67229553^1,2	C	--	35683787(+)	`AAAAA-/AC/CA AGTCA`	1	--	int¹		0	--	--	--	--
rs28705923^1,2	C	--	55609293(+)	`AAATAC/TTCACT`	1	--	us2k¹		0	--	--	--	--
rs73415532^1,2	C,F	--	55609310(+)	`TAAAAG/TGAAAT`	1	--	us2k¹		7		WA CSA NA EA	365
rs180774134^1,2		--	55609328(+)	`CTGTCC/TTGGTA`	1	--	us2k¹		0	--	--	--	--
rs35126191^1,2	C	--	55609388(+)	`AGGTT-/AAAAAA`	1	--	us2k¹		0	--	--	--	--
rs34473609^1,2	C,F	--	55609565(+)	`TGGAGT/GGCAGC`	1	--	us2k¹		3		NA	6
rs186129575^1,2		--	55609590(+)	`TCACTC/GCCACC`	1	--	us2k¹		0	--	--	--	--
rs190590233^1,2	C	--	55609621(+)	`GATGCC/TCCTGC`	1	--	us2k¹		0	--	--	--	--
rs28685005^1,2	C,F	--	55609692(+)	`ATTTTT/CAGTAG`	1	--	us2k¹		6		NA WA CSA	10

HapMap Linkage Disequilibrium report for PIGB (55611133 - 55647846 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for PIGB: About this table

Variant ID	Type	Subtype	PubMed ID
esv267383	CNV	Insertion	20981092
nsv904243	CNV	Loss	21882294
nsv520799	CNV	Loss	19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604122 OMIM disorders: --

1 disease for PIGB:
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griscelli syndrome

Find genes that share disorders with PIGB About GenesLikeMe

Genetic Association Database (GAD): PIGB
Human Genome Epidemiology (HuGE) Navigator: PIGB (1 document)

Export disorders for PIGB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PIGB gene, integrated from 10 sources (see all 13):
(articles sorted by number of sources associating them with PIGB)

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world of online information

PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor. (PubMed id 8861954)^{1, 2, 3, 9} Takahashi M.... Kinoshita T. (EMBO J. 1996)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Glycoinositol phospholipid anchor-defective K562 mutants with biochemical lesions distinct from those in Thy-1- murine lymphoma mutants. (PubMed id 7907094)^{1, 2} Mohney R.P.... Medof M.E. (J. Biol. Chem. 1994)
Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)¹ Emanuele M.J....Elledge S.J. (Cell 2011)
siRNA-mediated inhibition of phosphatidylinositol glycan Class B (PIGB) confers resistance to methylmercury in HEK293 cells. (PubMed id 18198489)¹ Hwang G.W....Naganuma A. (J Toxicol Sci 2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (Genome Res. 2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (Nat. Genet. 2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
Evidence that Griscelli syndrome with neurological involvement is caused by mutations in RAB27A, not MYO5A. (PubMed id 12058346)¹ Anikster Y.... Hurvitz H. (Am. J. Hum. Genet. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9488	HGNC: 8959	AceView: PIGB	Ensembl:ENSG00000069943	euGenes: HUgn9488
ECgene: PIGB	Kegg: 9488	H-InvDB: PIGB

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PIGB	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PIGB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PIGB gene:
Search GeneIP for patents involving PIGB

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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PIGB Gene

Phosphatidylinositol Glycan Anchor Biosynthesis, Class B

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Phosphatidylinositol Glycan Anchor Biosynthesis, Class B

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