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PIGA Gene

protein-coding GIFtS: 65

GC0XM015247

phosphatidylinositol glycan anchor biosynthesis, class A
(Previous names: phosphatidylinositol glycan, class A (paroxysmal nocturnal hemoglobinuria) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.4.1.198 ^³
GPI3 ^¹, ²
OTTHUMP00000022959 ^²
PIG-A ^², ³

Descriptions
GPI anchor biosynthesis ^²
GlcNAc-PI synthesis protein ^², ³
Phosphatidylinositol-glycan biosynthesis class A protein ^³
phosphatidylinositol N-acetylglucosaminyltransferase subunit A ^²
phosphatidylinositol glycan anchor biosynthesis, class A ^²
phosphatidylinositol glycan, class A (paroxysmal nocturnal hemoglobinuria) ^¹
phosphatidylinositol-glycan biosynthesis, class A protein ^²

External Ids
HGNC: 8957¹
Entrez Gene: 5277²
UniProtKB: P37287³
Ensembl: ENSG00000165195⁷

Search outside databases for aliases for PIGA gene

Previous GC identifers: GC0XM014782 GC0XM014163 GC0XM014539 GC0XM014699 GC0XM015097

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PIGA:

This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol

(GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a

glycolipid found on many blood cells and which serves to anchor proteins to the cell surface.

Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result

from mutations in this gene. Alternate splice variants have been characterized. [provided by

RefSeq]

UniProtKB/Swiss-Prot: PIGA_HUMAN, P37287

Function: Necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early

intermediate in GPI-anchor biosynthesis

Gene Wiki entry for PIGA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PIGA gene

Entrez Gene cytogenetic band: Xp22.1 Ensembl cytogenetic band: Xp22.2 HGNC cytogenetic band: Xp22.1

PIGA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM015247: (about GC identifiers)

Start:	15,247,499 bp from pter
End:	15,263,581 bp from pter
Size:	16,083 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000023.9 NT_011757.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PIGA_HUMAN, P37287 (See protein sequence)

Recommended Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

Size: 484 amino acids; 54127 Da

Subunit: Associates with PIGC, PIGH, PIGP, PIGQ and DPM2. The latter is not essential for activity.

Interacts directly with PIGY

Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein

Secondary accessions: Q16025 Q16250

Alternative splicing: 2 isoforms: P37287-1 P37287-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_002632.1 NP_065206.2

ENSEMBL proteins:

ENSP00000369820 ENSP00000351532

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PIGA)
	Human Recombinant Proteins from Abnova (PIGA)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	IDA	16162815
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005789	endoplasmic reticulum membrane	IDA	16162815
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for PIGA:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (PIGA), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for PIGA

Assays for PIGA:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P37287

ProtoNet protein and cluster: P37287

1 Blocks protein family: IPB001296 Glycosyl transferase

UniProtKB/Swiss-Prot: PIGA_HUMAN, P37287

Similarity: Belongs to the glycosyltransferase 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PIGA)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002641

Applied Biosystems Silencer® siRNAs for PIGA

Sigma-Aldrich siRNA for PIGA

Sigma-Aldrich shRNA for PIGA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002641
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002641
untagged cDNA clones in CMV expression vector (see all 4): NM_002641

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002641

UniProtKB/Swiss-Prot: PIGA_HUMAN, P37287

Function: Necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early

intermediate in GPI-anchor biosynthesis

Catalytic activity: UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP +

6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol

Enzyme Number (IUBMB): EC 2.4.1.198

Genatlas biochemistry entry for PIGA:

glycosyl-phosphatidylinositol (GPI),54kDa,anchor synthesis,class A,putatively involved in apoptosis

regulation

14 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Piga):

behavior/neurological	cellular	craniofacial	digestive/alimentary	embryogenesis
growth/size	hematopoietic system	lethality-postnatal	lethality-prenatal/perinatal	nervous system
reproductive system	skeleton	skin/coat/nails	tumorigenesis

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16162815
GO:0016757	transferase activity, transferring glycosyl groups	IEA	--
GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	TAS	16162815

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: PIGA_HUMAN, P37287

Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis

Gene Network Central^TM Interacting Genes and Proteins Network for PIGA

5/19 Interacting proteins for PIGA (ENSP00000369820³) via UniProtKB, MINT, and/or STRING (see all 19 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PIGH	ENSP00000216452³	STRING (score=.999)
THADA	ENSP00000331105³	STRING (score=.999)
PIGQ	ENSP00000026218³	STRING (score=.998)
PIGC	ENSP00000356702³	STRING (score=.996)
DPM2	ENSP00000362202³	STRING (score=.991)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009058	biosynthetic process	IEA	--
GO:0009893	positive regulation of metabolic process	TAS	16162815
GO:0016254	preassembly of GPI anchor in ER membrane	EXP	11102867

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PIGA
4 Novoseek chemical compound relationships for PIGA gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
aerolysin	79.42	3	15687243 (2), 11212264 (1)
n-acetylglucosamine	56.99	3	8806613 (1), 8647522 (1), 18522757 (1)
udp-n-acetylglucosamine	54.02	2	8806613 (1), 18522757 (1)
phosphatidylinositol	40.99	3	8806613 (1), 8900170 (1), 18522757 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PIGA)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002641

Sigma-Aldrich siRNA for PIGA

Sigma-Aldrich shRNA for PIGA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002641 NM_020473

REFSEQ mRNAs for PIGA gene (2 alternative transcripts):

NM_002641.2 NM_020473.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002641 NM_020473

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002641
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002641
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_002641

Additional cDNA sequence:

AK098047.1 AK290497.1 AK303538.1 AK304144.1 AK315063.1 BC038236.1 D11466.1 S61523.1

S74936.1

6 DOTS entries:

DT.95366694 DT.213216 DT.99982419 DT.102823086 DT.121309992 DT.92422332

24/76 AceView cDNA sequences (see all 76 ):

BQ026278 AU098475 CB157876 CF138539 D11466 NM_020472 BX113864 AI417807

NM_020473 BC038236 CB989816 CF994958 AU136655 NM_002641 BM725982 BM787996

AU127618 BQ026877 BX498283 N33325 BM548209 CD641690 AU129607 CB989512

highest scoring ESTs for PIGA:

D11466 AU139488 AA280576 AA424735 AA495864 AA730046 AI082575 AI287677 AI417096 AI537052

Unigene Cluster for PIGA:

Phosphatidylinositol glycan anchor biosynthesis, class A

Hs.137154 [show with all ESTs]

Unigene Representative Sequence: NM_002641

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PIGA (see all 6 )

ExUns:	1	^	2a	·	2b	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6a	·	6b
SP1:			-		-		-				-
SP2:							-				-
SP3:					-		-				-
SP4:					-		-		-		-
SP5:											-

About this scheme

ECgene alternative splicing isoforms for PIGA

2 Ensembl transcripts including schematic representations:

ENST00000333590 ENST00000358698

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PIGA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PIGA

¹ / ² / ³

4 probe-sets matching PIGA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
221_s_at²^{, 3}	U95-A	1	1.00	1.00	0.90	0.61	S78467	0.20	0.25	0.23	2
39993_at²^{, 3}	U95-A	1	1.00	1.00	0.88	1.39	D11466	1.00	1.00	1.00	1
205281_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002641	0.60	1.00	0.82	1
205281_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCCAAAAATA

SOURCE GeneReport for Unigene cluster: Hs.137154
Expression variation in blood from EXPOLDB for PIGA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PIGA gene from 5/21 species (see all 21 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PIGA¹	--	phosphatidylinositol glycan anchor biosynthesis, class more	91.67(n) 93.18(a)	491748 XM_548868.2 XP_548868.1
chimpanzee (Pan troglodytes)	PIGA¹	--	phosphatidylinositol glycan anchor biosynthesis, class more	99.79(n) 99.79(a)	465507 XM_520945.2 XP_520945.2
rat (Rattus norvegicus)	Piga¹	--	phosphatidylinositol glycan anchor biosynthesis, class more	88.15(n) 88.64(a)	363464 XM_343783.3 XP_343784.1
mouse (Mus musculus)	Piga^{1, 5}	X (70.00 cM)⁵	phosphatidylinositol glycan anchor biosynthesis, class more^{1, 5}	87.81(n)¹ 87.81(a)¹	18700¹ NM_011081.2¹ NP_035211.2¹ AI194334⁵ AK032283⁵ (see all 24)
chicken (Gallus gallus)	PIGA¹	--	phosphatidylinositol glycan anchor biosynthesis, class more	78.68(n) 89.41(a)	418624 NM_001030808.1 NP_001025979.1

About this table Species with no ortholog for PIGA

ENSEMBL Gene Tree for PIGA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/77 NCBI SNPs in PIGA are shown (see all 77 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 39)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3434^1,2	A,C,F,H	15247535(+)	`GGACAT/CGTAGC`	2	--	ut3¹ ese³		13		NS EU EA WA NA	774
	rs3087965^1,2	A,C,F,H	15247803(+)	`ATCACA/TTGTTT`	2	--	ut3¹		8		EU EA WA NA	594
	rs6527494^1,2	A,C,F,H	15264231(+)	`GTGGTA/GTGACG`	2	--	ng3¹		12		EU EA WA NA	815
	rs3661^1,2	A,C,F,H	15247923(+)	`GTGGCA/GTGCCT`	2	--	ut3¹ ese³		6		EU EA WA NA	590
--	rs6632348^1,2	A,C	15263908(+)	`CGTGCC/GGGTTC`	2	--	ng3¹		0	--	--	--	--
--	rs6632314^1,2	C	15247065(+)	`aatacA/Cctaat`	2	--	ng5¹		0	--	--	--	--
--	rs5935951^1,2	A	15247089(+)	`aaaaaA/Gaaaga`	2	--	ng5¹		0	--	--	--	--
--	rs5934235^1,2	A	15247042(+)	`aaataA/Tataaa`	2	--	ng5¹		0	--	--	--	--
	rs5935952^1,2	H	15247454(+)	`TTCCAC/GTAGTA`	2	--	ng5¹		4		EU EA WA	398
	rs2543^1,2	A,C,F,H,O	15255766(+)	`TTCTCG/ATACAA`	2	--	int¹		9		EU EA WA NA	736

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HapMap Linkage Disequilibrium images for PIGA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 311770

UniProtKB/Swiss-Prot: PIGA_HUMAN, P37287

Defects in PIGA are the cause of paroxysmal nocturnal hemoglobinuria (PNH) [MIM:311770].

PNH is an acquired hemolytic blood disorder characterized by chronic hemolysis with

hemoglobinuria, increased tendency to venous thrombosis, and variable degrees of bone marrow

failure Biosynthesis of the GPI anchor is deficient in patients with PNH leading to deficient

surface expression of GPI-anchored proteins such as DAF or CD59 which play roles in the protection

of red cells from the action of complement

10/18 Novoseek disease relationships for PIGA gene (see all 18 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
paroxysmal hemoglobinuria nocturnal	98.21	103	8541557 (3), 10389589 (2), 9129055 (2), 16923549 (2) (see all 85)
hemolysis intravascular	92.32	2	16940417 (1), 11372757 (1)
anemia hemolytic acquired	91.58	3	19074066 (1), 8541557 (1), 11301179 (1)
somatic mutations	90.87	105	10087994 (3), 8500164 (3), 7655005 (3), 7986731 (2) (see all 82)
anemia aplastic	86.72	18	10233427 (2), 16467865 (2), 8619404 (1), 11750098 (1) (see all 15)
hemoglobinuria	84.80	1	11372733 (1)
anemia hemolytic	72.87	1	17124035 (1)
hemolysis	71.50	2	12627846 (1), 11756148 (1)
cytopenia	66.10	1	14584753 (1)
hematologic disorders	64.33	4	10389589 (1), 7543308 (1), 7485098 (1), 9238050 (1)

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Genetic Association Database: PIGA

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/183 PubMed articles for PIGA gene (see all 183 ):

Deficiency of the GPI anchor caused by a somatic mutation of the PIG- A gene in paroxysmal nocturnal hemoglobinuria. (PubMed id 8500164)^{1, 2, 3, 4} Takeda J.... Kinoshita T. (1993)
Genomic organization of the X-linked gene (PIG-A) that is mutated in paroxysmal nocturnal haemoglobinuria and of a related autosomal pseudogene mapped to 12q21. (PubMed id 8081362)^{1, 3, 4} Bessler M.... Mason P.J. (1994)
The spectrum of somatic mutations in the PIG-A gene in paroxysmal nocturnal hemoglobinuria includes large deletions and small duplications. (PubMed id 10087994)^{1, 3, 4} Nafa K.... Luzzatto L. (1998)
Characterization of genomic PIG-A gene: a gene for glycosylphosphatidylinositol-anchor biosynthesis and paroxysmal nocturnal hemoglobinuria. (PubMed id 8193350)^{1, 3, 4} Iida Y.... Kinoshita T. (1994)
Mutations within the Piga gene in patients with paroxysmal nocturnal hemoglobinuria. (PubMed id 8167330)^{1, 3, 4} Ware R.E.... Howard T.A. (1994)
Paroxysmal nocturnal haemoglobinuria (PNH) is caused by somatic mutations in the PIG-A gene. (PubMed id 8306954)^{1, 3, 4} Bessler M.... Kinoshita T. (1994)
The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis. (PubMed id 7680492)^{1, 3, 4} Miyata T.... Kinoshita T. (1993)
The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component. (PubMed id 16162815)^{3, 4} Murakami Y....Kinoshita T. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Mutation analysis of the PIG-A gene in Korean patients with paroxysmal nocturnal haemoglobinuria. (PubMed id 12037021)^{3, 4} Yoon J.H.... Kim B.K. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5277	HGNC: 8957	AceView: PIGA	Ensembl:ENSG00000165195	euGenes: HUgn5277
ECgene: PIGA	H-InvDB: PIGA

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
Functional Glycomics Gateway - GTase	http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_555

Licensable Technologies for PIGA
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for PIGA:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PIGA-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PIGA		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PIGA		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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PIGA Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for PIGA

Summaries
for PIGA

Genomic Location
for PIGA

Proteins
for PIGA

Protein Domains/
Families
for PIGA

Gene Function
for PIGA

Pathways & Interactions
for PIGA

Drugs & Compounds
for PIGA

Transcripts
for PIGA

Expression
for PIGA

Orthologs
for PIGA

Paralogs
for PIGA

SNPs/Variants
for PIGA

Disorders & Mutations
for PIGA

Medical News
for PIGA

Publications
for PIGA

Search for PIGA

Genome Databases showing PIGA

Other Databases showing PIGA

Specialized Databases showing PIGA

Licensable Technologies
for PIGA

Services
for PIGA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PIGA Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor PIGA

Summariesfor PIGA

Genomic Locationfor PIGA

Proteinsfor PIGA

Protein Domains/Familiesfor PIGA

Gene Functionfor PIGA

Pathways & Interactionsfor PIGA

Drugs & Compoundsfor PIGA

Transcriptsfor PIGA

Expression for PIGA

Orthologsfor PIGA

Paralogsfor PIGA

SNPs/Variantsfor PIGA

Disorders & Mutationsfor PIGA

Medical Newsfor PIGA

Publicationsfor PIGA

Search for PIGA

Genome Databases showing PIGA

Other Databases showing PIGA

Specialized Databases showing PIGA

Licensable Technologiesfor PIGA

Servicesfor PIGA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PIGA

Summaries
for PIGA

Genomic Location
for PIGA

Proteins
for PIGA

Protein Domains/
Families
for PIGA

Gene Function
for PIGA

Pathways & Interactions
for PIGA

Drugs & Compounds
for PIGA

Transcripts
for PIGA

Expression
for PIGA

Orthologs
for PIGA

Paralogs
for PIGA

SNPs/Variants
for PIGA

Disorders & Mutations
for PIGA

Medical News
for PIGA

Publications
for PIGA

Licensable Technologies
for PIGA

Services
for PIGA