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Aliases for PIFO Gene

Aliases for PIFO Gene

  • Primary Cilia Formation 2 3 5
  • C1orf88 3 4
  • Chromosome 1 Open Reading Frame 88 2
  • Pitchfork 3

External Ids for PIFO Gene

Previous HGNC Symbols for PIFO Gene

  • C1orf88

Previous GeneCards Identifiers for PIFO Gene

  • GC01P111889

Summaries for PIFO Gene

GeneCards Summary for PIFO Gene

PIFO (Primary Cilia Formation) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding and beta-tubulin binding.

UniProtKB/Swiss-Prot for PIFO Gene

  • During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIFO Gene

Genomics for PIFO Gene

Genomic Location for PIFO Gene

Chromosome:
1
Start:
111,324,515 bp from pter
End:
111,353,017 bp from pter
Size:
28,503 bases
Orientation:
Plus strand

Genomic View for PIFO Gene

Genes around PIFO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIFO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIFO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIFO Gene

No data available for Regulatory Elements for PIFO Gene

Proteins for PIFO Gene

  • Protein details for PIFO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCI5-PIFO_HUMAN
    Recommended name:
    Protein pitchfork
    Protein Accession:
    Q8TCI5
    Secondary Accessions:
    • D9J0A2
    • D9J0A3
    • Q4G0K4
    • Q52LJ6
    • Q5T5D5
    • Q5T5D6
    • Q8N310

    Protein attributes for PIFO Gene

    Size:
    191 amino acids
    Molecular mass:
    21973 Da
    Quaternary structure:
    • Interacts with proteins involved in ciliary transport, including ARL13B, CETN1, KIF3A, RAB6A, RAB8A, TUBB1 and TUBG1. Interacts with AURKA.

    Alternative splice isoforms for PIFO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIFO Gene

Proteomics data for PIFO Gene at MOPED

Post-translational modifications for PIFO Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIFO Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PIFO Gene

Domains & Families for PIFO Gene

Protein Domains for PIFO Gene

ProtoNet:

Suggested Antigen Peptide Sequences for PIFO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PIFO: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PIFO Gene

Function for PIFO Gene

Molecular function for PIFO Gene

UniProtKB/Swiss-Prot Function:
During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner.

Gene Ontology (GO) - Molecular Function for PIFO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043015 gamma-tubulin binding IDA 20643351
genes like me logo Genes that share ontologies with PIFO: view
genes like me logo Genes that share phenotypes with PIFO: view

Animal Models for PIFO Gene

MGI Knock Outs for PIFO:

Animal Model Products

miRNA for PIFO Gene

miRTarBase miRNAs that target PIFO

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIFO Gene

Localization for PIFO Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIFO Gene

Cytoplasmic vesicle. Golgi apparatus, trans-Golgi network. Cytoplasm. Note=Accumulates specifically at the basal body and ciliary necklace during the early steps of cilia assembly and disassembly, when structural, functional and regulatory proteins are delivered to cilia. At S phase, accumulates in vesicles and declines during mitosis. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIFO Gene COMPARTMENTS Subcellular localization image for PIFO gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 4
nucleus 3
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PIFO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036064 ciliary basal body ISS --
genes like me logo Genes that share ontologies with PIFO: view

Pathways & Interactions for PIFO Gene

SuperPathways for PIFO Gene

No Data Available

Interacting Proteins for PIFO Gene

Gene Ontology (GO) - Biological Process for PIFO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033674 positive regulation of kinase activity IMP 20643351
genes like me logo Genes that share ontologies with PIFO: view

No data available for Pathways by source and SIGNOR curated interactions for PIFO Gene

Drugs & Compounds for PIFO Gene

No Compound Related Data Available

Transcripts for PIFO Gene

Unigene Clusters for PIFO Gene

Primary cilia formation:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIFO Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2: -
SP3: - -
SP4: - - -
SP5:

Relevant External Links for PIFO Gene

GeneLoc Exon Structure for
PIFO
ECgene alternative splicing isoforms for
PIFO

Expression for PIFO Gene

mRNA expression in normal human tissues for PIFO Gene

mRNA differential expression in normal tissues according to GTEx for PIFO Gene

This gene is overexpressed in Testis (x4.2).

SOURCE GeneReport for Unigene cluster for PIFO Gene Hs.172510

genes like me logo Genes that share expression patterns with PIFO: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PIFO Gene

Orthologs for PIFO Gene

This gene was present in the common ancestor of chordates.

Orthologs for PIFO Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C3H1orf88 35
  • 81.22 (n)
  • 71.82 (a)
PIFO 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC611691 35
  • 83.33 (n)
  • 75.54 (a)
-- 36
  • 73 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Pifo 35
  • 79.3 (n)
  • 69.23 (a)
Pifo 16
Pifo 36
  • 52 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PIFO 35
  • 99.13 (n)
  • 98.43 (a)
PIFO 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pifo 35
  • 78.57 (n)
  • 68.68 (a)
oppossum
(Monodelphis domestica)
Mammalia PIFO 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIFO 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIFO 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIFO 36
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PIFO 36
  • 42 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3194 36
  • 39 (a)
OneToOne
Species with no ortholog for PIFO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PIFO Gene

ENSEMBL:
Gene Tree for PIFO (if available)
TreeFam:
Gene Tree for PIFO (if available)

Paralogs for PIFO Gene

No data available for Paralogs for PIFO Gene

Variants for PIFO Gene

Sequence variations from dbSNP and Humsavar for PIFO Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs15396 - 111,348,548(+) CAGAA(A/C)GTAAG intron-variant, reference, missense
rs2184884 - 111,348,570(-) TTTGT(G/T)TTTTT intron-variant, reference, missense
rs150508940 - 111,347,753(+) TGTGA(A/G)GTTTA intron-variant, reference, missense
rs1668 -- 111,351,336(-) GTAGT(C/T)ACAGC nc-transcript-variant, utr-variant-3-prime
rs1058530 -- 111,352,865(+) AGAGA(C/T)GCTCA nc-transcript-variant, utr-variant-3-prime

Variation tolerance for PIFO Gene

Residual Variation Intolerance Score: 69.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.63; 56.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIFO Gene

HapMap Linkage Disequilibrium report
PIFO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PIFO Gene

Disorders for PIFO Gene

Relevant External Links for PIFO

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIFO

No disorders were found for PIFO Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIFO Gene

Publications for PIFO Gene

  1. Pitchfork regulates primary cilia disassembly and left-right asymmetry. (PMID: 20643351) Kinzel D. … Lickert H. (Dev. Cell 2010) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  5. Generation and analysis of 280,000 human expressed sequence tags. (PMID: 8889549) Hillier L.D. … Marra M. (Genome Res. 1996) 3

Products for PIFO Gene

Sources for PIFO Gene

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