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Aliases for PIFO Gene

Aliases for PIFO Gene

  • Primary Cilia Formation 2 3 5
  • C1orf88 3 4
  • Chromosome 1 Open Reading Frame 88 2
  • Protein Pitchfork 3
  • Pitchfork 3

External Ids for PIFO Gene

Previous HGNC Symbols for PIFO Gene

  • C1orf88

Previous GeneCards Identifiers for PIFO Gene

  • GC01P111889

Summaries for PIFO Gene

GeneCards Summary for PIFO Gene

PIFO (Primary Cilia Formation) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding and beta-tubulin binding.

UniProtKB/Swiss-Prot for PIFO Gene

  • During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIFO Gene

Genomics for PIFO Gene

Regulatory Elements for PIFO Gene

Enhancers for PIFO Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F111369 0.5 ENCODE 11.3 +45.3 45349 1.2 FOS ATF2 PIFO OVGP1 CHIAP3 LOC105378904
GH01F111399 0.2 ENCODE 10.8 +75.5 75499 0.2 CTCF PKNOX1 ZNF654 CEBPB CEBPG REST RAD21 CEBPA SMC3 OVGP1 PIFO DENND2D PGCP1
GH01F111371 0.2 ENCODE 10.6 +47.8 47837 2.3 CTBP1 GATA3 ZNF207 NBN ETV6 GABPA PIFO ENSG00000260948 LOC105378904 HIGD1AP12
GH01F111211 1.4 FANTOM5 Ensembl ENCODE 10.6 -102.1 -102114 21.2 MLX CREB3L1 YBX1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 TBX21 CHI3L2 DENND2D ENSG00000232240 LOC105378903 PIFO ATP5F1 WDR77 OVGP1 CEPT1 CD53
GH01F111615 0.5 ENCODE 5.3 +291.8 291824 2.2 HDGF TBP PKNOX1 WRNIP1 EBF1 RELA POLR2A EED ETV6 CREM RAP1A KRT18P57 RNU6-151P ATP5F1 WDR77 UBE2FP3 PIFO LINC01160
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PIFO on UCSC Golden Path with GeneCards custom track

Genomic Location for PIFO Gene

Chromosome:
1
Start:
111,324,515 bp from pter
End:
111,353,017 bp from pter
Size:
28,503 bases
Orientation:
Plus strand

Genomic View for PIFO Gene

Genes around PIFO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIFO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIFO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIFO Gene

Proteins for PIFO Gene

  • Protein details for PIFO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCI5-PIFO_HUMAN
    Recommended name:
    Protein pitchfork
    Protein Accession:
    Q8TCI5
    Secondary Accessions:
    • D9J0A2
    • D9J0A3
    • Q4G0K4
    • Q52LJ6
    • Q5T5D5
    • Q5T5D6
    • Q8N310

    Protein attributes for PIFO Gene

    Size:
    191 amino acids
    Molecular mass:
    21973 Da
    Quaternary structure:
    • Interacts with proteins involved in ciliary transport, including ARL13B, CETN1, KIF3A, RAB6A, RAB8A, TUBB1 and TUBG1. Interacts with AURKA.

    Alternative splice isoforms for PIFO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIFO Gene

Post-translational modifications for PIFO Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIFO Gene

No data available for DME Specific Peptides for PIFO Gene

Domains & Families for PIFO Gene

Protein Domains for PIFO Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PIFO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PIFO: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PIFO Gene

Function for PIFO Gene

Molecular function for PIFO Gene

UniProtKB/Swiss-Prot Function:
During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner.

Gene Ontology (GO) - Molecular Function for PIFO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20643351
GO:0017137 Rab GTPase binding IPI 20643351
GO:0019894 kinesin binding IPI 20643351
GO:0019901 protein kinase binding IPI 20643351
GO:0043015 gamma-tubulin binding IDA 20643351
genes like me logo Genes that share ontologies with PIFO: view
genes like me logo Genes that share phenotypes with PIFO: view

Animal Models for PIFO Gene

MGI Knock Outs for PIFO:

Animal Model Products

miRNA for PIFO Gene

miRTarBase miRNAs that target PIFO

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIFO Gene

Localization for PIFO Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIFO Gene

Cytoplasmic vesicle. Golgi apparatus, trans-Golgi network. Cytoplasm. Note=Accumulates specifically at the basal body and ciliary necklace during the early steps of cilia assembly and disassembly, when structural, functional and regulatory proteins are delivered to cilia. At S phase, accumulates in vesicles and declines during mitosis. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIFO Gene COMPARTMENTS Subcellular localization image for PIFO gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 4
nucleus 3
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PIFO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005802 trans-Golgi network ISS --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with PIFO: view

Pathways & Interactions for PIFO Gene

SuperPathways for PIFO Gene

No Data Available

Interacting Proteins for PIFO Gene

Selected Interacting proteins: Q8TCI5-PIFO_HUMAN for PIFO Gene via IID

Gene Ontology (GO) - Biological Process for PIFO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030030 cell projection organization IEA --
GO:0031344 regulation of cell projection organization ISS --
GO:0033674 positive regulation of kinase activity IMP 20643351
genes like me logo Genes that share ontologies with PIFO: view

No data available for Pathways by source and SIGNOR curated interactions for PIFO Gene

Transcripts for PIFO Gene

Unigene Clusters for PIFO Gene

Primary cilia formation:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIFO Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2: -
SP3: - -
SP4: - - -
SP5:

Relevant External Links for PIFO Gene

GeneLoc Exon Structure for
PIFO
ECgene alternative splicing isoforms for
PIFO

Expression for PIFO Gene

mRNA expression in normal human tissues for PIFO Gene

mRNA differential expression in normal tissues according to GTEx for PIFO Gene

This gene is overexpressed in Testis (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of PIFO Gene:

PIFO

SOURCE GeneReport for Unigene cluster for PIFO Gene:

Hs.172510
genes like me logo Genes that share expression patterns with PIFO: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PIFO Gene

Orthologs for PIFO Gene

This gene was present in the common ancestor of chordates.

Orthologs for PIFO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIFO 34 35
  • 99.13 (n)
dog
(Canis familiaris)
Mammalia LOC611691 34
  • 83.33 (n)
-- 35
  • 73 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
cow
(Bos Taurus)
Mammalia C3H1orf88 34
  • 81.22 (n)
PIFO 35
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pifo 34 16 35
  • 79.3 (n)
rat
(Rattus norvegicus)
Mammalia Pifo 34
  • 78.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PIFO 35
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIFO 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIFO 35
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIFO 35
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PIFO 35
  • 42 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3194 35
  • 39 (a)
OneToOne
Species where no ortholog for PIFO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PIFO Gene

ENSEMBL:
Gene Tree for PIFO (if available)
TreeFam:
Gene Tree for PIFO (if available)

Paralogs for PIFO Gene

No data available for Paralogs for PIFO Gene

Variants for PIFO Gene

Sequence variations from dbSNP and Humsavar for PIFO Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10158004 -- 111,351,086(+) ATAAA(A/G)GGTAG intron-variant
rs1058530 -- 111,352,865(+) AGAGA(C/T)GCTCA nc-transcript-variant, utr-variant-3-prime
rs10776724 -- 111,326,865(+) catat(A/C)cacgt intron-variant
rs10776725 -- 111,342,838(+) aggag(A/G)ggtgc intron-variant
rs10776726 -- 111,344,690(+) AATAC(A/G)TTTCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PIFO Gene

Variant ID Type Subtype PubMed ID
nsv463250 CNV loss 19166990
nsv547535 CNV loss 21841781

Variation tolerance for PIFO Gene

Residual Variation Intolerance Score: 69.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.63; 56.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIFO Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIFO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIFO Gene

Disorders for PIFO Gene

Relevant External Links for PIFO

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIFO

No disorders were found for PIFO Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIFO Gene

Publications for PIFO Gene

  1. Pitchfork regulates primary cilia disassembly and left-right asymmetry. (PMID: 20643351) Kinzel D. … Lickert H. (Dev. Cell 2010) 2 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for PIFO Gene

Sources for PIFO Gene

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