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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PIF1 Gene

protein-coding   GIFtS: 49
GCID: GC15M065107

PIF1 5'-To-3' DNA Helicase

(Previous names: chromosome 15 open reading frame 20, PIF1 5'-to-3' DNA helicase...)
(Previous symbol: C15orf20)
  Search for PIF1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
PIF1 5'-To-3' DNA Helicase1 2     DNA Helicase Homolog PIF12
C15orf201 2 3     DNA Helicase PIF12
PIF1/RRM3 DNA Helicase-Like Protein2 3     Petite Integration Frequency 12
PIF2 5     PIF1 5'-To-3' DNA Helicase Homolog2
Chromosome 15 Open Reading Frame 201     PIF1 DNA Helicase2
PIF1 5'-To-3' DNA Helicase Homolog (S. Cerevisiae)1     EC 3.6.4.123
ATP-Dependent DNA Helicase PIF12     EC 3.6.18

External Ids:    HGNC: 262201   Entrez Gene: 801192   Ensembl: ENSG000001404517   OMIM: 6109535   UniProtKB: Q9H6113   

Export aliases for PIF1 gene to outside databases

Previous GC identifers: GC15M060839 GC15M058207 GC15M062686 GC15U900236 GC15M062895 GC15M041934


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PIF1 Gene:
PIF1 is a 5-prime-to-3-prime DNA helicase that negatively regulates telomerase (see TERT; MIM 187270), a reverse
transcriptase that maintains telomere length (Zhang et al., 2006 (PubMed 16522649)).(supplied by OMIM, Mar 2008)

GeneCards Summary for PIF1 Gene: 
PIF1 (PIF1 5'-to-3' DNA helicase) is a protein-coding gene. GO annotations related to this gene include ATP-dependent 5'-3' DNA helicase activity and magnesium ion binding.

UniProtKB/Swiss-Prot: PIF1_HUMAN, Q9H611
Function: DNA-dependent ATPase and DNA helicase inhibiting telomerase activity by unwinding DNA/RNA duplex formed
by telomerase RNA and telomeric DNA in a 5' to 3' polarity. Negatively regulates telomere length and such
inhibition requires its ATPase activity. Tightly cell cycle regulated and expressed in late S/G2 phase




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PIF1 gene promoter:
         E2F-3a   p53   E2F-2   AP-2gamma   c-Ets-1   PPAR-alpha   AREB6   E2F-1   E2F   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PIF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.31   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q22.1

PIF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIF1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M065107:  view genomic region     (about GC identifiers)

Start:
65,107,831 bp from pter      End:
65,117,867 bp from pter
Size:
10,037 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PIF1_HUMAN, Q9H611 (See protein sequence)
Recommended Name: ATP-dependent DNA helicase PIF1  
Size: 641 amino acids; 69799 Da
Subunit: Interacts with telomerase
Subcellular location: Nucleus
Subcellular location: Isoform 4: Mitochondrion
Secondary accessions: Q1W5B6 Q330H5 Q33E24
Alternative splicing, Alternative initiation: 4 isoforms:  Q9H611-1   Q9H611-2   Q9H611-3   Q9H611-4   (Produced by alternative initiation of isoform 1)

Explore the universe of human proteins at neXtProt for PIF1: NX_Q9H611

Explore proteomics data for PIF1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H611

  • 4/6 DME Specific Peptides for PIF1 (Q9H611) (see all 6)
     ATRLCTH  PFGGIQL  LDCVEISL  CGDFLQLPPVT 

    PIF1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PIF1 Protein Expression
    REFSEQ proteins: NP_079325.2  
    ENSEMBL proteins: 
     ENSP00000268043   ENSP00000328174   ENSP00000452792  

    Human Recombinant Protein Products for PIF1: 
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    Novus Biologicals PIF1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000784nuclear chromosome, telomeric region IDA16522649
    GO:0005739mitochondrion IEA--

    PIF1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR010285 DNA_helicase_PIF1
     IPR027417 P-loop_NTPase
     IPR003840 DNA_helicase

    Graphical View of Domain Structure for InterPro Entry Q9H611

    ProtoNet protein and cluster: Q9H611

    UniProtKB/Swiss-Prot: PIF1_HUMAN, Q9H611
    Similarity: Belongs to the helicase family


    PIF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIF1_HUMAN, Q9H611
    Function: DNA-dependent ATPase and DNA helicase inhibiting telomerase activity by unwinding DNA/RNA duplex formed
    by telomerase RNA and telomeric DNA in a 5' to 3' polarity. Negatively regulates telomere length and such
    inhibition requires its ATPase activity. Tightly cell cycle regulated and expressed in late S/G2 phase
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.121

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA16522649
    GO:0003678DNA helicase activity ----
    GO:0004386helicase activity ----
    GO:0005524ATP binding IDA16522649
    GO:0017116single-stranded DNA-dependent ATP-dependent DNA helicase activity IDA16522649
         
    PIF1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PIF1:
     Decreased nuclei size in G2M 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pif1):
     cellular  normal 

    PIF1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pif1tm1Leah for PIF1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PIF1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PIF1

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    miRNA
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    hsa-miR-485-5p hsa-miR-676 hsa-miR-646 hsa-miR-4287 hsa-miR-942 hsa-miR-1184 hsa-miR-130b* hsa-miR-2355-3p
    SwitchGear 3'UTR luciferase reporter plasmidPIF1 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIF1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PIF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/50 Interacting proteins for PIF1 (Q9H6113 ENSP000002680434) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASF1AQ9Y2943, ENSP000002295954I2D: score=1 STRING: ENSP00000229595
    DNA2P515303, ENSP000003821334I2D: score=1 STRING: ENSP00000382133
    ERCC2P180743, ENSP000003758094I2D: score=1 STRING: ENSP00000375809
    ERCC4Q928893, ENSP000003105204I2D: score=1 STRING: ENSP00000310520
    FEN1P397483, ENSP000003054804I2D: score=1 STRING: ENSP00000305480
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000723telomere maintenance IEA--
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination IEA--
    GO:0032204regulation of telomere maintenance IDA16522649
    GO:0051974negative regulation of telomerase activity IDA16522649

    PIF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PIF1

    Search CenterWatch for drugs/clinical trials and news about PIF1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PIF1 gene: 
    NM_025049.2  

    Unigene Cluster for PIF1:

    PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)
    Hs.112160  [show with all ESTs]
    Unigene Representative Sequence: AB185926
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268043(uc002anr.2 uc002ans.2 uc002ant.2) ENST00000333425
    ENST00000559239(uc010uiq.1) ENST00000559872 ENST00000559522 ENST00000558380
    ENST00000558547 ENST00000560444(uc002anu.3) ENST00000560504
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIF1
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate PIF1 (see all 9):
    hsa-miR-485-5p hsa-miR-676 hsa-miR-646 hsa-miR-4287 hsa-miR-942 hsa-miR-1184 hsa-miR-130b* hsa-miR-2355-3p
    SwitchGear 3'UTR luciferase reporter plasmidPIF1 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIF1
    Sirion Biotech Customized lentivirus for stable overexpression of PIF1 
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PIF1
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIF1

    Additional mRNA sequence: 

    AB185926.1 AB185927.1 AF108138.1 AK026345.1 AY498716.1 BC018978.2 BC033254.1 BC137503.1 
    BC137504.1 DQ437529.1 EU084033.1 

    6 DOTS entries:

    DT.100742237  DT.312339  DT.75109371  DT.97823271  DT.95259868  DT.102823193 

    24/52 AceView cDNA sequences (see all 52):

    BQ958807 AW004048 BG231673 AW590310 AI745642 BC033254 BE387734 AI655645 
    W60651 AA872541 BF516453 BQ061682 CF137126 AA642924 AI652391 AI696210 
    AI654749 NM_025049 AA279102 AI984536 BC018978 AI280491 AF108138 CA310274 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PIF1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b
    SP1:              -           -                 -                                             
    SP2:                                            -                                             
    SP3:                          -     -           -           -                                 
    SP4:                                            -           -                                 
    SP5:                                                                                          


    ECgene alternative splicing isoforms for PIF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PIF1 expression in normal human tissues (normalized intensities)      PIF1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGAAGCCTC
    PIF1 Expression
    About this image


    PIF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/44 selected tissues (see all 44) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
             spinal cord/lateral wall/ventricular layer   
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             mouse/organ system/cardiovascular system   

    See PIF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PIF1

    SOURCE GeneReport for Unigene cluster: Hs.112160

    UniProtKB/Swiss-Prot: PIF1_HUMAN, Q9H611
    Tissue specificity: Weak ubiquitous expression

        SABiosciences Expression via Pathway-Focused PCR Array including PIF1: 
              Telomeres & Telomerase in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PIF1 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pif11 , 5 PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)1, 5 85.09(n)1
    86.97(a)1
      9 (35.40 cM)5
    2080841  NM_172453.31  NP_766041.11 
     655871605 
    chicken
    (Gallus gallus)
    Aves PIF16
    PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)...
    58(a)
    1 ↔ 1
    8(18504655-18513032)
    lizard
    (Anolis carolinensis)
    Reptilia PIF16
    PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)...
    57(a)
    1 ↔ 1
    4(107009481-107023317)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.244142 Xenopus laevis transcribed sequence with weak similarity more 72.18(n)    BU912019.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pif11 PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae) 61.43(n)
    60.94(a)
      326729  NM_198807.1  NP_942102.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG32381 , 3 CG32381 50(a)3
    52.49(n)1
    47.73(a)1
      23F33
    335671  NM_134938.21  NP_608782.11 
    worm
    (Caenorhabditis elegans)
    Secernentea pif-11 Protein PIF-1 47.36(n)
    43.79(a)
      171665  NM_058373.4  NP_490774.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PIF1(YML061C)4 DNA helicase; exists in a nuclear form that acts as more   --   13(151532-148953) 854941  NP_013650.1 


    ENSEMBL Gene Tree for PIF1 (if available)
    TreeFam Gene Tree for PIF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PIF1 gene
    1 SIMAP similar gene for PIF1 using alignment to 2 protein entries:     PIF1_HUMAN (see all proteins):
    C15orf20

    PIF1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/417 SNPs in PIF1 are shown (see all 417)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1406943311,2
    C--65107578(+) GGTCTC/TGAACT 1 -- ds50010--------
    rs1117522431,2
    C,F--65107606(+) CACCCA/GCCTCG 1 -- ds50015Minor allele frequency- G:0.44NA WA CSA 9
    rs1454861861,2
    C--65107651(+) ATCATA/GCCCGG 1 -- ds50010--------
    rs558415241,2
    C,F--65107655(+) TGCCCG/AGTGAC 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs563032481,2
    C,F--65107658(+) CCGGTG/AACAAT 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs172083011,2
    C,F,H--65107759(+) AGCCAC/TTGTGG 1 -- ds500128Minor allele frequency- T:0.21NA NS EA WA CSA 2907
    rs727447941,2
    C,F--65107778(+) AACACG/ATGTGT 1 -- ds50015Minor allele frequency- A:0.09WA NA CSA 244
    rs752994921,2
    C,F--65107795(+) GCACAA/GGTGAG 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs749355061,2
    C,F--65107804(+) AGAGGG/TGGAGA 1 -- ds50015Minor allele frequency- T:0.16NA CSA WA EA 362
    rs1384344931,2
    --65107808(+) GGGGAA/GAGAGA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for PIF1 (65107831 - 65117867 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PIF1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv904307CNV Loss21882294
    dgv31n68CNV Loss17160897


    Human Gene Mutation Database (HGMD): PIF1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PIF1 for disorders           About MalaCards
    OMIM gene information: 610953    OMIM disorders: --


    PIF1 for disorders           About GeneDecksing


    Export disorders for PIF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PIF1 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with PIF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity. (PubMed id 16522649)1, 2, 3 Zhang D.H....Zhou J.Q. (2006)
    2. Human PIF helicase is cell cycle regulated and associates with telomerase. (PubMed id 17172855)1, 2 Mateyak M.K. and Zakian V.A. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Pif1p helicase, a catalytic inhibitor of telomerase in yeast. (PubMed id 10926538)1, 3 Zhou J....Zakian V.A. (2000)
    5. Human Pif1 helicase unwinds synthetic DNA structures resembling stalled DNA replication forks. (PubMed id 19700773)1, 9 George T....Sanders C.M. (2009)
    6. Mitochondrial and nuclear localization of human Pif1 helicase. (PubMed id 17827721)1, 9 Futami K....Furuichi Y. (2007)
    7. Pif1 family helicases suppress genome instability at G -quadruplex motifs. (PubMed id 23657261)1 Paeschke K....Zakian V.A. (2013)
    8. Yeast Pif1 helicase exhibits a one-base-pair stepping mechanism for unwinding duplex DNA. (PubMed id 23596008)1 Ramanagoudr-Bhojappa R....Raney K.D. (2013)
    9. Alternative translation initiation augments the human mitochondrial proteome. (PubMed id 23275553)2 Kazak L.... Holt I.J. (2013)
    10. A genomewide screen for suppressors of Alu-mediated re arrangements reveals a role for PIF1. (PubMed id 22347400)1 Chisholm K.M....Welcsh P.L. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80119 HGNC: 26220 AceView: C15orf20 Ensembl:ENSG00000140451 euGenes: HUgn80119
    ECgene: PIF1 H-InvDB: PIF1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PIF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PIF1 gene:
    Search GeneIP for patents involving PIF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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