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PIEZO1 Gene

protein-coding   GIFtS: 47
GCID: GC16M088781

Piezo-Type Mechanosensitive Ion Channel Component 1

(Previous names: family with sequence similarity 38, member A)
(Previous symbol: FAM38A)
  See PIEZO1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Piezo-Type Mechanosensitive Ion Channel Component 11 2     DHS2 5
FAM38A1 2 3 5     Protein PIEZO12
Family With Sequence Similarity 38, Member A1 2     KIAA02333
Membrane Protein Induced By Beta-Amyloid Treatment2 3     Protein FAM38A3
Mib2 3     MIB5

External Ids:    HGNC: 289931   Entrez Gene: 97802   Ensembl: ENSG000001033357   OMIM: 6111845   UniProtKB: Q925083   

Export aliases for PIEZO1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PIEZO1 Gene:
Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted
transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The FAM38A gene encodes PIEZO1,
a protein that induces mechanically activated (MA) currents in various cell types (Coste et al., 2010 (PubMed
20813920)).(supplied by OMIM, Nov 2010)

GeneCards Summary for PIEZO1 Gene:
PIEZO1 (piezo-type mechanosensitive ion channel component 1) is a protein-coding gene. Diseases associated with PIEZO1 include dehydrated hereditary stomatocytosis, and dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema. GO annotations related to this gene include mechanically-gated ion channel activity and cation channel activity. An important paralog of this gene is PIEZO2.

UniProtKB/Swiss-Prot: PIEZ1_HUMAN, Q92508
Function: Pore-forming subunit of a mechanosensitive non-specific cation channel, that conducts both sodium and
potassium ions. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras
recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for PIEZO1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for PIEZO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIEZO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.3   Ensembl cytogenetic band:  16q24.3   HGNC cytogenetic band: 16q24.3

PIEZO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIEZO1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M088781:  view genomic region     (about GC identifiers)

Start:
88,781,746 bp from pter      End:
88,851,619 bp from pter
Size:
69,874 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PIEZ1_HUMAN, Q92508 (See protein sequence)
Recommended Name: Piezo-type mechanosensitive ion channel component 1  
Size: 2521 amino acids; 286790 Da
Subunit: Homooligomer, most likely homotetramer (By similarity)
Developmental stage: At 17 weeks of gestation, strongly expressed in hepatic erythroblasts. At that stage, also
expressed in fetal splenic plasma cells and in lymphatic vessel of fetal peritoneum. In vitro, up-regulated
during the erythroid differentiation of CD34+ cells from healthy donors (at protein level)
Miscellaneous: Piezo comes from the Greek 'piesi' meaning pressure
Secondary accessions: A6NHT9 A7E2B7 Q0KKZ9

Explore the universe of human proteins at neXtProt for PIEZO1: NX_Q92508

Explore proteomics data for PIEZO1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys113, Lys1334, Lys1953, Lys2372
  • Glycosylation2 at Asn295, Asn2294, Asn2331
  • Modification sites at PhosphoSitePlus

  • See PIEZO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001136336.2  
    ENSEMBL proteins: 
     ENSP00000456680   ENSP00000406358   ENSP00000301015   ENSP00000456373   ENSP00000428673  
     ENSP00000333704  

    PIEZO1 Human Recombinant Protein Products:

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    Novus Biologicals PIEZO1 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for PIEZO1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR027272 Piezo

    Graphical View of Domain Structure for InterPro Entry Q92508

    ProtoNet protein and cluster: Q92508

    UniProtKB/Swiss-Prot: PIEZ1_HUMAN, Q92508
    Similarity: Belongs to the PIEZO family


    Find genes that share domains with PIEZO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIEZ1_HUMAN, Q92508
    Function: Pore-forming subunit of a mechanosensitive non-specific cation channel, that conducts both sodium and
    potassium ions. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras
    recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005261cation channel activity ISS--
    GO:0008381mechanically-gated ion channel activity IEA--
         
    Find genes that share ontologies with PIEZO1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PIEZO1:
     Decreased influenza A virus in 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PIEZO1
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    miRNA
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    miRTarBase miRNAs that target PIEZO1:
    hsa-mir-10b-5p (MIRT006294), hsa-mir-940 (MIRT036601)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PIEZ1_HUMAN, Q92508: Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi
    intermediate compartment membrane. Cell membrane; Multi-pass membrane protein. Note=In erythrocytes, located in
    the plasma membrane

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005886plasma membrane ISS--
    GO:0016021integral component of membrane IEA--
    GO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane IEA--

    Find genes that share ontologies with PIEZO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PIEZO1
    Interactions:

        Search GeneGlobe Interaction Network for PIEZO1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for PIEZO1 (ENSP000003010154) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006812cation transport ISS--
    GO:0033625positive regulation of integrin activation IMP--
    GO:0033634positive regulation of cell-cell adhesion mediated by integrin IMP--
    GO:0042391regulation of membrane potential IEA--
    GO:0050982detection of mechanical stimulus IEA--

    Find genes that share ontologies with PIEZO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PIEZO1 (PIEZ1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PIEZO1 gene: 
    NM_001142864.2  

    Unigene Cluster for PIEZO1:

    Piezo-type mechanosensitive ion channel component 1
    Hs.377001  [show with all ESTs]
    Unigene Representative Sequence: NM_001142864
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000518793 ENST00000484567(uc002flo.4 uc002flp.4) ENST00000419505(uc002flq.4)
    ENST00000301015(uc010cib.3 uc010vpb.2) ENST00000521877 ENST00000472168
    ENST00000495568 ENST00000466823 ENST00000497793 ENST00000566414 ENST00000474606
    ENST00000475586 ENST00000491917 ENST00000490756 ENST00000327397
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PIEZO1
      QuantiFast Probe-based Assays in human, mouse, rat PIEZO1

    Additional mRNA sequence: 

    AB161230.1 AK092007.1 AK097851.1 AL832442.1 BC008073.2 BC016983.1 BC141877.1 BC150271.1 
    D87071.1 

    16 DOTS entries:

    DT.445633  DT.100793358  DT.87016061  DT.100793342  DT.91761333  DT.100793354  DT.120679267  DT.100806060 
    DT.92041403  DT.75152394  DT.91832644  DT.100793353  DT.120679259  DT.97848238  DT.120715719  DT.95225224 

    Selected AceView cDNA sequences (see all 270):

    BM762298 BE408399 AI828745 AA059421 BF525918 BU848817 AK097851 BM695275 
    AI493730 BM988951 AI655080 AA353544 CR608234 BE502205 CD626044 BQ277940 
    AI983280 AW179051 CR605984 AW241528 BQ958576 BM676414 BM830439 CD626048 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PIEZO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCAAGTGGA
    PIEZO1 Expression
    About this image


    PIEZO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
     
     Lung (Respiratory System)
     
     Adipose (Muscoskeletal System)
    PIEZO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIEZO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.377001

    UniProtKB/Swiss-Prot: PIEZ1_HUMAN, Q92508
    Tissue specificity: Expressed in numerous tissues. In normal brain, expressed exclusively in neurons, not in
    astrocytes. In Alzheimer disease brains, expressed in about half of the activated astrocytes located around
    classical senile plaques. In Parkinson disease substantia nigra, not detected in melanin-containing neurons nor
    in activated astrocytes. Expressed in erythrocytes (at protein level)

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PIEZO1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Piezo11 , 5 family with sequence similarity 38, member A5
    piezo-type mechanosensitive ion channel component 11
    81.9(n)1
    82.26(a)1
      8 (71.31 cM)5
    2348391  NM_001037298.11  NP_001032375.11 
     1224817125 
    chicken
    (Gallus gallus)
    Aves FAM38A1 family with sequence similarity 38, member A 74.02(n)
    69.97(a)
      415849  XM_414209.4  XP_414209.4 
    lizard
    (Anolis carolinensis)
    Reptilia PIEZO16
    piezo-type mechanosensitive ion channel component ...
    60(a)
    1 ↔ 1
    GL343670.1(170456-235758)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480329702   -- 78.6(n)    48032970 
    zebrafish
    (Danio rerio)
    Actinopterygii piezo11 piezo-type mechanosensitive ion channel component 1 63.06(n)
    59.58(a)
      567949  XM_691263.5  XP_696355.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG410566
    Piezo6
    Piezo
    29(a)
    23(a)
    many ↔ many
    many ↔ many
    3RHet(1130828-1310687)
    2L(8163298-8190044)
    worm
    (Caenorhabditis elegans)
    Secernentea T20D3.116
    Protein T20D3.11, isoform a (T20D3.11) mRNA, compl...
    24(a)
    1 → many
    IV(9343358-9355764) WBGene00011862


    ENSEMBL Gene Tree for PIEZO1 (if available)
    TreeFam Gene Tree for PIEZO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PIEZO1 gene
    PIEZO22  
    2 SIMAP similar genes for PIEZO1 using alignment to 7 protein entries:     PIEZ1_HUMAN (see all proteins):
    FAM38A    PIEZO2

    Find genes that share paralogs with PIEZO1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PIEZO1 (see all 1933)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0698284
    Dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema (DHS)4--see VAR_0698282 A T mis40--------
    VAR_0698234
    Dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema (DHS)4--see VAR_0698232 G S mis40--------
    VAR_0698274
    Dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema (DHS)4--see VAR_0698272 A D mis40--------
    VAR_0698224
    Dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema (DHS)4--see VAR_0698222 G S mis40--------
    VAR_0698324
    Dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema (DHS)4--see VAR_0698322 M R mis40--------
    VAR_0698334
    Dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema (DHS)4--see VAR_0698332 R H mis40--------
    VAR_0698264
    Dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema (DHS)4--see VAR_0698262 R P mis40--------
    VAR_0698244
    Dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema (DHS)4--see VAR_0698242 R Q mis40--------
    VAR_0698344
    Dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema (DHS)4--see VAR_0698342 R Q mis40--------
    VAR_0698294
    Dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema (DHS)4--see VAR_0698292 A V mis40--------

    HapMap Linkage Disequilibrium report for PIEZO1 (88781746 - 88851619 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PIEZO1 (see all 49):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715037CNV Deletion23290073
    esv2667582CNV Deletion23128226
    esv2715034CNV Deletion23290073
    esv2715027CNV Deletion23290073
    esv2715035CNV Deletion23290073
    esv2715036CNV Deletion23290073
    esv2247831CNV Deletion18987734
    esv2715032CNV Deletion23290073
    esv1041922CNV Deletion17803354
    esv2715031CNV Deletion23290073

    Human Gene Mutation Database (HGMD): PIEZO1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PIEZO1
    DNA2.0 Custom Variant and Variant Library Synthesis for PIEZO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611184   
    OMIM disorders: 194380  
    UniProtKB/Swiss-Prot: PIEZ1_HUMAN, Q92508
  • Dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema (DHS)
    [MIM:194380]: An autosomal dominant hemolytic anemia characterized by primary erythrocyte dehydration. DHS
    erythrocytes exhibit decreased total cation and potassium content that are not accompanied by a proportional net
    gain of sodium and water. DHS patients typically exhibit mild to moderate compensated hemolytic anemia, with an
    increased erythrocyte mean corpuscular hemoglobin concentration and a decreased osmotic fragility, both of which
    reflect cellular dehydration. Patients may also show perinatal edema and pseudohyperkalemia due to loss of
    potassium from red cells stored at room temperature. A minor proportion of red cells appear as stomatocytes on
    blood films. Complications such as splenomegaly and cholelithiasis, resulting from increased red cell trapping in
    the spleen and elevated bilirubin levels, respectively, may occur. The course of DHS is frequently associated
    with iron overload, which may lead to hepatosiderosis. Note=The disease is caused by mutations affecting the gene
    represented in this entry. All disease-causing mutations characterized so far produce a gain-of-function
    phenotype, mutated channels exhibiting increased cation transport in erythroid cells, that could be due to slower
    channel inactivation rate compared to the wild-type protein

  • 2 diseases for PIEZO1:    
    About MalaCards
    dehydrated hereditary stomatocytosis    dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema


    Find genes that share disorders with PIEZO1           About GenesLikeMe


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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIEZO1 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with PIEZO1)
        Utopia: connect your pdf to the dynamic
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    1. Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels. (PubMed id 23695678)1, 2 Albuisson J....Patapoutian A. (Nat Commun 2013)
    2. Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1. (PubMed id 23479567)1, 2 Andolfo I....Iolascon A. (Blood 2013)
    3. Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis. (PubMed id 22529292)1, 2 Zarychanski R....Gallagher P.G. (Blood 2012)
    4. [Feeling the pressure? Identification of two proteins activated by mechanical forces]. (PubMed id 21299953)1, 3 Coste B. (Med Sci (Paris) 2011)
    5. The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4. (PubMed id 21696149)1, 3 Bae C....Gottlieb P.A. (Biochemistry 2011)
    6. Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum. (PubMed id 20016066)1, 2 McHugh B.J.... Sethi T. (J. Cell Sci. 2010)
    7. Mechanosensitive channels: in touch with Piezo. (PubMed id 21056836)1, 3 Xiao R. and Xu X.Z. (Curr. Biol. 2010)
    8. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. (PubMed id 20813920)1, 3 Coste B....Patapoutian A. (Science 2010)
    9. A novel membrane protein, encoded by the gene covering KIAA0233, is transcriptionally induced in senile plaque-associated astrocytes. (PubMed id 16854388)1, 2 Satoh K.... Yamada T. (Brain Res. 2006)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9780 HGNC: 28993 AceView: FAM38A Ensembl:ENSG00000103335 euGenes: HUgn9780
    ECgene: PIEZO1 H-InvDB: PIEZO1

    (According to HUGE)
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    HUGE: KIAA0233

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PIEZO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PIEZO1 gene:
    Search GeneIP for patents involving PIEZO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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