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Aliases for PIDD1 Gene

Aliases for PIDD1 Gene

  • P53-Induced Death Domain Protein 1 2 3 5
  • Leucine-Rich Repeat And Death Domain-Containing Protein 3 4
  • Leucine-Rich Repeats And Death Domain Containing 2 3
  • LRDD 3 4
  • PIDD 3 4
  • P53-Induced Protein With A Death Domain 3
  • P53-Induced Death Domain Protein 2

External Ids for PIDD1 Gene

Previous HGNC Symbols for PIDD1 Gene

  • LRDD
  • PIDD

Summaries for PIDD1 Gene

Entrez Gene Summary for PIDD1 Gene

  • The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

GeneCards Summary for PIDD1 Gene

PIDD1 (P53-Induced Death Domain Protein 1) is a Protein Coding gene. Among its related pathways are p53 Pathway (RnD) and Gene Expression. GO annotations related to this gene include death receptor binding. An important paralog of this gene is LRRC8A.

UniProtKB/Swiss-Prot for PIDD1 Gene

  • Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways.

Gene Wiki entry for PIDD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIDD1 Gene

Genomics for PIDD1 Gene

Regulatory Elements for PIDD1 Gene

Enhancers for PIDD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PIDD1 on UCSC Golden Path with GeneCards custom track

Promoters for PIDD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PIDD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PIDD1 Gene

Chromosome:
11
Start:
799,179 bp from pter
End:
809,753 bp from pter
Size:
10,575 bases
Orientation:
Minus strand

Genomic View for PIDD1 Gene

Genes around PIDD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIDD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIDD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIDD1 Gene

Proteins for PIDD1 Gene

  • Protein details for PIDD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB75-PIDD1_HUMAN
    Recommended name:
    p53-induced death domain-containing protein 1
    Protein Accession:
    Q9HB75
    Secondary Accessions:
    • Q59FD1
    • Q59H10
    • Q59HC7
    • Q7Z4P8
    • Q8NC89
    • Q8NDL2
    • Q96C25
    • Q9NRE6

    Protein attributes for PIDD1 Gene

    Size:
    910 amino acids
    Molecular mass:
    99712 Da
    Quaternary structure:
    • Interacts with FADD and MAP-kinase activating death domain/MADD. Forms a complex with IKBKG and with receptor-interacting serine-threonine kinase 1/RIP1. Forms also a complex named PIDDosome with CASP2 and CRADD.
    SequenceCaution:
    • Sequence=BAD92069.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92186.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92766.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD38708.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PIDD1 Gene

    Alternative splice isoforms for PIDD1 Gene

neXtProt entry for PIDD1 Gene

Proteomics data for PIDD1 Gene at MOPED

Post-translational modifications for PIDD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIDD1 Gene

No data available for DME Specific Peptides for PIDD1 Gene

Domains & Families for PIDD1 Gene

Suggested Antigen Peptide Sequences for PIDD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HB75

UniProtKB/Swiss-Prot:

PIDD1_HUMAN :
  • Contains 1 death domain.
  • Contains 7 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 death domain.
  • Contains 1 peptidase S68 domain.
  • Contains 2 ZU5 domains.
Similarity:
  • Contains 7 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with PIDD1: view

No data available for Gene Families for PIDD1 Gene

Function for PIDD1 Gene

Molecular function for PIDD1 Gene

UniProtKB/Swiss-Prot Function:
Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways.
UniProtKB/Swiss-Prot Induction:
Induced by gamma-irradiation.
genes like me logo Genes that share phenotypes with PIDD1: view

Animal Models for PIDD1 Gene

MGI Knock Outs for PIDD1:

Animal Model Products

CRISPR Products

miRNA for PIDD1 Gene

miRTarBase miRNAs that target PIDD1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIDD1 Gene

Localization for PIDD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIDD1 Gene

Cytoplasm. Nucleus.

Gene Ontology (GO) - Cellular Components for PIDD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IMP 21726810
genes like me logo Genes that share ontologies with PIDD1: view

No data available for Subcellular locations from COMPARTMENTS for PIDD1 Gene

Pathways & Interactions for PIDD1 Gene

genes like me logo Genes that share pathways with PIDD1: view

Gene Ontology (GO) - Biological Process for PIDD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA --
GO:0006974 cellular response to DNA damage stimulus IEA,IDA 21726810
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP 21726810
GO:0007165 signal transduction IEA,TAS 10825539
genes like me logo Genes that share ontologies with PIDD1: view

No data available for SIGNOR curated interactions for PIDD1 Gene

Drugs & Compounds for PIDD1 Gene

No Compound Related Data Available

Transcripts for PIDD1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PIDD1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a ·
SP1: - - - -
SP2: - - -
SP3: - - -
SP4:
SP5: - -
SP6: - -
SP7: -
SP8:
SP9:
SP10:

ExUns: 14b ^ 15 ^ 16a · 16b · 16c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PIDD1 Gene

GeneLoc Exon Structure for
PIDD1
ECgene alternative splicing isoforms for
PIDD1

Expression for PIDD1 Gene

mRNA expression in normal human tissues for PIDD1 Gene

Protein differential expression in normal tissues from HIPED for PIDD1 Gene

This gene is overexpressed in Rectum (33.2), Prostate (15.1), Peripheral blood mononuclear cells (11.3), and Platelet (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PIDD1 Gene



mRNA Expression by UniProt/SwissProt for PIDD1 Gene

Q9HB75-PIDD1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with PIDD1: view

Protein tissue co-expression partners for PIDD1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PIDD1 Gene

Orthologs for PIDD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PIDD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PIDD 35
  • 83.15 (n)
  • 82.31 (a)
PIDD 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIDD 35
  • 81.68 (n)
  • 82.31 (a)
PIDD 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrdd 35
  • 81.3 (n)
  • 81.63 (a)
Pidd1 16
Lrdd 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LRDD 35
  • 98.79 (n)
  • 98.24 (a)
rat
(Rattus norvegicus)
Mammalia LOC100911519 35
  • 80.51 (n)
  • 80.66 (a)
oppossum
(Monodelphis domestica)
Mammalia PIDD 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIDD 35
  • 62.43 (n)
  • 57.97 (a)
PIDD 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIDD 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pidd 35
  • 56 (n)
  • 51.34 (a)
zebrafish
(Danio rerio)
Actinopterygii pidd 35
  • 54.96 (n)
  • 50.06 (a)
pidd 36
  • 42 (a)
OneToOne
Species with no ortholog for PIDD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PIDD1 Gene

ENSEMBL:
Gene Tree for PIDD1 (if available)
TreeFam:
Gene Tree for PIDD1 (if available)

Paralogs for PIDD1 Gene

genes like me logo Genes that share paralogs with PIDD1: view

Variants for PIDD1 Gene

Sequence variations from dbSNP and Humsavar for PIDD1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10902221 - 802,379(+) AGCCT(C/G/T)GAGGG nc-transcript-variant, reference, missense
rs7117921 -- 800,486(-) TCCCC(A/G)AGCCC intron-variant
rs7118632 -- 807,184(-) gagag(A/G)gagtc intron-variant, upstream-variant-2KB
rs7121646 -- 800,485(-) CCCCG(A/C/T)GCCCT intron-variant
rs7122416 -- 807,149(-) agtgc(C/T)gagat intron-variant, upstream-variant-2KB

Variation tolerance for PIDD1 Gene

Residual Variation Intolerance Score: 60.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.01; 84.18% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for PIDD1 Gene

Disorders for PIDD1 Gene

Relevant External Links for PIDD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIDD1

No disorders were found for PIDD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIDD1 Gene

Publications for PIDD1 Gene

  1. LRDD, a novel leucine rich repeat and death domain containing protein. (PMID: 10825539) Telliez J.-B. … Lin L.-L. (Biochim. Biophys. Acta 2000) 2 3 4 67
  2. p53-induced protein with a death domain (PIDD) isoforms differentially activate nuclear factor-kappaB and caspase-2 in response to genotoxic stress. (PMID: 17637755) Cuenin S. … Tschopp J. (Oncogene 2008) 3 23
  3. Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. (PMID: 16652156) Vakifahmetoglu H. … Zhivotovsky B. (Oncogene 2006) 3 23
  4. Upon intracellular processing, the C-terminal death domain-containing fragment of the p53-inducible PIDD/LRDD protein translocates to the nucleoli and interacts with nucleolin. (PMID: 16982033) Pick R. … ZAPrnig M. (Biochem. Biophys. Res. Commun. 2006) 3 23
  5. PIDD mediates NF-kappaB activation in response to DNA damage. (PMID: 16360037) Janssens S. … Tschopp J. (Cell 2005) 3 23

Products for PIDD1 Gene

Sources for PIDD1 Gene

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