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PIDD Gene

protein-coding   GIFtS: 50
GCID: GC11M000799

P53-Induced Death Domain Protein

(Previous name: leucine-rich repeats and death domain containing)
(Previous symbol: LRDD)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
P53-Induced Death Domain Protein1 2
LRDD1 2 3
Leucine-Rich Repeats And Death Domain Containing1 2
Leucine-Rich Repeat And Death Domain-Containing Protein2 3
P53-Induced Protein With A Death Domain2

External Ids:    HGNC: 164911   Entrez Gene: 553672   Ensembl: ENSG000001775957   OMIM: 6052475   UniProtKB: Q9HB753   

Export aliases for PIDD gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PIDD Gene:
The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to
interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and
MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell
death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be
positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which
suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Aug 2010)

GeneCards Summary for PIDD Gene:
PIDD (p53-induced death domain protein) is a protein-coding gene. GO annotations related to this gene include death receptor binding. An important paralog of this gene is LRRC2.

UniProtKB/Swiss-Prot: PIDD_HUMAN, Q9HB75
Function: Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response
pathway that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and
ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates
with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic
pathways

Gene Wiki entry for PIDD (LRDD) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for PIDD
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIDD promoter sequence
   Search Chromatin IP Primers for PIDD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIDD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

PIDD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIDD gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M000799:  view genomic region     (about GC identifiers)

Start:
799,179 bp from pter      End:
809,753 bp from pter
Size:
10,575 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PIDD_HUMAN, Q9HB75 (See protein sequence)
Recommended Name: p53-induced protein with a death domain  
Size: 910 amino acids; 99712 Da
Subunit: Interacts with FADD and MAP-kinase activating death domain/MADD. Forms a complex with IKBKG and with
receptor-interacting serine-threonine kinase 1/RIP1. Forms also a complex named PIDDosome with CASP2 and CRADD
Sequence caution: Sequence=BAD92069.1; Type=Erroneous initiation; Sequence=BAD92186.1; Type=Erroneous initiation;
Sequence=BAD92766.1; Type=Erroneous initiation; Sequence=CAD38708.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for PIDD:
2OF5 (3D)    
Secondary accessions: Q59FD1 Q59H10 Q59HC7 Q7Z4P8 Q8NC89 Q8NDL2 Q96C25 Q9NRE6
Alternative splicing: 7 isoforms:  Q9HB75-1   Q9HB75-2   Q9HB75-3   Q9HB75-4   Q9HB75-5   Q9HB75-6   Q9HB75-7   

Explore the universe of human proteins at neXtProt for PIDD: NX_Q9HB75

Explore proteomics data for PIDD at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PIDD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_665893.2  NP_665894.2  

    ENSEMBL proteins: 
     ENSP00000436342   ENSP00000436146   ENSP00000416801   ENSP00000337797   ENSP00000435008  

    PIDD Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for PIDD 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR001611 Leu-rich_rpt
     IPR011029 DEATH-like_dom
     IPR000906 ZU5
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR019502 Peptidase_S68_pidd

    Graphical View of Domain Structure for InterPro Entry Q9HB75

    ProtoNet protein and cluster: Q9HB75

    1 Blocks protein domain: IPB000488 Death domain

    UniProtKB/Swiss-Prot: PIDD_HUMAN, Q9HB75
    Similarity: Contains 1 death domain
    Similarity: Contains 7 LRR (leucine-rich) repeats
    Similarity: Contains 1 peptidase S68 domain
    Similarity: Contains 2 ZU5 domains


    Find genes that share domains with PIDD           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIDD_HUMAN, Q9HB75
    Function: Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response
    pathway that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and
    ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates
    with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic
    pathways
    Induction: Induced by gamma-irradiation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005123death receptor binding TAS10825539
    GO:0005515protein binding IPI15073321
         
    Find genes that share ontologies with PIDD           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Lrdd):
     normal 

    Find genes that share phenotypes with PIDD           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Lrddtm1.1Anvi for PIDD

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PIDD
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PIDD_HUMAN, Q9HB75: Cytoplasm. Nucleus

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IMP--
    GO:0005737cytoplasm IMP--
    GO:0005794Golgi apparatus IDA--

    Find genes that share ontologies with PIDD           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PIDD About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1p53 signaling pathway
    DNA damage response0.41
    p53 signaling pathway0.41
    2Apoptosis Signaling Pathways
    Apoptosis Signaling Pathways0.35
    3Apoptosis and survival Caspase cascade
    Caspase cascade in apoptosis0.42
    4NF-kappa B signaling pathway
    NF-kappa B signaling pathway
    5miRNA Regulation of DNA Damage Response
    miRNA Regulation of DNA Damage Response


    Find genes that share SuperPaths with PIDD           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for PIDD
        Apoptosis Signaling Pathways


    4 BioSystems Pathways for PIDD
        DNA damage response
    miRNA Regulation of DNA Damage Response
    Caspase cascade in apoptosis
    Direct p53 effectors


    2 Kegg Pathways  (Kegg details for PIDD):
        NF-kappa B signaling pathway
    p53 signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PIDD: 
              p53 Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Necrosis in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PIDD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PIDD (Q9HB751, 2, 3 ENSP000003377974) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRADDP785601, 2, 3, ENSP000003276474EBI-520427,EBI-520375 MINT-4054932 MINT-4054980 I2D: score=4 STRING: ENSP00000327647
    CCDC85BQ158342, 3, ENSP000003116954MINT-68191 I2D: score=5 STRING: ENSP00000311695
    EFEMP2O959672, 3, ENSP000003099534MINT-66608 I2D: score=4 STRING: ENSP00000309953
    PRKDCP785271, 3, ENSP000003134204EBI-520427,EBI-352053 I2D: score=1 STRING: ENSP00000313420
    MDFIQ997501, 2, 3, ENSP000002303214EBI-520427,EBI-724076 MINT-67603 I2D: score=5 STRING: ENSP00000230321
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process ----
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IEA--
    GO:0006974cellular response to DNA damage stimulus IDA--
    GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP--
    GO:0007165signal transduction TAS10825539

    Find genes that share ontologies with PIDD           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PIDD



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PIDD gene (3 alternative transcripts): 
    NM_145886.3  NM_145887.3  NM_018494.3  

    Unigene Cluster for PIDD:

    P53-induced death domain protein
    Hs.592290  [show with all ESTs]
    Unigene Representative Sequence: AB208949
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000525028 ENST00000524486(uc009yck.1 uc001lrl.1 uc001lrm.1)
    ENST00000411829 ENST00000347755(uc001lrk.2 uc001lro.2 uc001lrn.2)
    ENST00000531286 ENST00000527357(uc001lrp.2) ENST00000534525 ENST00000527812
    ENST00000528122 ENST00000534649 ENST00000530911
    miRNA
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    Additional mRNA sequence: 

    AB208949.1 AF229178.1 AF274972.1 BC014904.1 

    16 DOTS entries:

    DT.95169519  DT.100785201  DT.120711455  DT.100785204  DT.310979  DT.92428086  DT.101983856  DT.120711483 
    DT.100025396  DT.92428083  DT.95177180  DT.95366067  DT.433630  DT.92428087  DT.102833869  DT.95366065 

    Selected AceView cDNA sequences (see all 109):

    BQ721262 CD244581 BG820900 AA377586 CF528561 BI766625 CD672628 CB145597 
    AW293446 BM765548 AI193673 BF902863 BQ013382 BQ214414 NM_145887 AW300752 
    BM068852 AI022161 AI674982 CK904475 BM783215 BE884565 CF131984 BM750094 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PIDD (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a ·
    SP1:        -     -           -                 -                                                                                                               
    SP2:                                            -                                                                 -     -                                       
    SP3:                          -                 -                                                                                                     -         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                    -                             -         

    ExUns: 14b ^ 15 ^ 16a · 16b · 16c
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for PIDD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PIDD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTTGGCCC
    PIDD Expression
    About this image


    PIDD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Bone (Muscoskeletal System)
             Bone Marrow
    PIDD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIDD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592290

    UniProtKB/Swiss-Prot: PIDD_HUMAN, Q9HB75
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PIDD: 
              p53 Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Necrosis in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIDD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PIDD gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrdd1 , 5 leucine-rich and death domain containing1, 5 81.3(n)1
    81.63(a)1
      7 (86.79 cM)5
    579131  NM_022654.11  NP_073145.11 
     1414381135 
    chicken
    (Gallus gallus)
    Aves PIDD1 p53-induced death domain protein 62.43(n)
    57.97(a)
      426464  XM_004941461.1  XP_004941518.1 
    lizard
    (Anolis carolinensis)
    Reptilia PIDD6
    p53-induced death domain protein
    54(a)
    1 ↔ 1
    1(73759679-73781713)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pidd1 p53-induced death domain protein 56(n)
    51.34(a)
      100488788  XM_002937500.2  XP_002937546.2 
    zebrafish
    (Danio rerio)
    Actinopterygii pidd1 p53-induced death domain protein 54.96(n)
    50.06(a)
      571033  XM_694585.5  XP_699677.5 


    ENSEMBL Gene Tree for PIDD (if available)
    TreeFam Gene Tree for PIDD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PIDD gene
    LRRC22  LRCH22  LRRC182  LRSAM12  LRRC302  LRCH32  LRRC572  LRRC10B2  
    LRRC392  LRCH42  LRRC102  LRCH12  

    Find genes that share paralogs with PIDD           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PIDD (see all 333)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs71124171,2
    C--623167(-) caccaC/Ggccca 2 -- int10--------
    rs1876729281,2
    --623168(+) GGGCGC/TGGTGG 2 -- int10--------
    rs2001821421,2
    C--800291(+) CCAAGC/TGGCCT 2 -- int10--------
    rs2019513861,2
    --800302(+) GGGGGG/TCCTCT 2 -- int10--------
    rs3741156051,2
    C--800309(+) CTCTCC/TCCTCA 2 -- int10--------
    rs1151734191,2
    C,F--800414(+) TAGAAG/AACAAA 4 /V syn13Minor allele frequency- A:0.02WA NA EU 5953
    rs1474055581,2
    C,F--800432(+) CTGCCC/TTCCAC 4 E syn12Minor allele frequency- T:0.00NA EU 5843
    rs1997522481,2
    C--800453(+) CGGTCT/CAGGGG 2 -- spa11Minor allele frequency- C:0.00EU 1193
    rs1878341931,2
    C--800457(+) CTAGGA/GGACAG 2 -- int10--------
    rs2008809151,2
    C,F--800459(+) AGGGGA/GCAGGG 2 -- int11Minor allele frequency- G:0.00EU 1189

    HapMap Linkage Disequilibrium report for PIDD (799179 - 809753 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PIDD (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv182e199CNV Deletion23128226
    nsv469923CNV Loss18288195
    dgv946n71CNV Loss21882294
    dgv944n71CNV Loss21882294
    dgv921n71CNV Loss21882294
    dgv936n71CNV Loss21882294
    dgv945n71CNV Loss21882294
    nsv896587CNV Loss21882294
    dgv948n71CNV Loss21882294
    nsv896599CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PIDD
    DNA2.0 Custom Variant and Variant Library Synthesis for PIDD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605247    OMIM disorders: --


    Find genes that share disorders with PIDD           About GenesLikeMe

    1 Novoseek inferred disease relationship for PIDD gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 15640352 (1)


    Export disorders for PIDD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIDD gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with PIDD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. LRDD, a novel leucine rich repeat and death domain containing protein. (PubMed id 10825539)1, 2, 3 Telliez J.-B.... Lin L.-L. (Biochim. Biophys. Acta 2000)
    2. PIDD mediates NF-kappaB activation in response to DNA damage. (PubMed id 16360037)1, 2, 9 Janssens S.... Tschopp J. (Cell 2005)
    3. Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. (PubMed id 16652156)1, 2, 9 Vakifahmetoglu H.... Zhivotovsky B. (Oncogene 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The PIDDosome, a protein complex implicated in activation of caspase- 2 in response to genotoxic stress. (PubMed id 15073321)1, 2 Tinel A. and Tschopp J. (Science 2004)
    7. Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis. (PubMed id 10973264)1, 2 Lin Y.... Benchimol S. (Nat. Genet. 2000)
    8. Upon intracellular processing, the C-terminal death domain-containing fragment of the p53-inducible PIDD/LRDD protein translocates to the nucleoli and interacts with nucleolin. (PubMed id 16982033)1, 9 Pick R....ZAPrnig M. (Biochem. Biophys. Res. Commun. 2006)
    9. p53-induced protein with a death domain (PIDD) isoforms differentially activate nuclear factor-kappaB and caspase-2 in response to genotoxic stress. (PubMed id 17637755)1, 9 Cuenin S....Tschopp J. (Oncogene 2008)
    10. PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling. (PubMed id 22854598)1 Ando K....Sidi S. (Mol. Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55367 HGNC: 16491 AceView: LRDD Ensembl:ENSG00000177595 euGenes: HUgn55367
    ECgene: PIDD Kegg: 55367 H-InvDB: PIDD

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PIDD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PIDD gene:
    Search GeneIP for patents involving PIDD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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