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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PIDD Gene

protein-coding GIFtS: 51
GCID: GC11M000799

p53-induced death domain protein

(Previous name: leucine-rich repeats and death domain containing )
(Previous symbol: LRDD)

Explore 5 diseases affiliated with
PIDD via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
P53-Induced Death Domain Protein¹ ²		DKFZp434D229¹
LRDD¹ ² ³		MGC16925¹
Leucine-Rich Repeats And Death Domain Containing¹ ²		P53-Induced Protein With A Death Domain²
Leucine-Rich Repeat And Death Domain-Containing Protein² ³

External Ids:	HGNC: 16491¹	Entrez Gene: 55367²	Ensembl: ENSG00000177595⁷	OMIM: 605247⁵	UniProtKB: Q9HB75³

Export aliases for PIDD gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PIDD:

The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to

interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase

activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related

signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by

the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene

as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. (provided by

RefSeq, Aug 2010)

UniProtKB/Swiss-Prot: PIDD_HUMAN, Q9HB75

Function: Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway

that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination

of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates with

CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways

Gene Wiki entry for PIDD (LRDD)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for PIDD
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PIDD promoter sequence

Search SABiosciences Chromatin IP Primers for PIDD

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIDD

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5

PIDD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIDD gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M000799: view genomic region (about GC identifiers)

Start:	799,179 bp from pter	End:	809,753 bp from pter
Size:	10,575 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PIDD_HUMAN, Q9HB75 (See protein sequence)

Recommended Name: p53-induced protein with a death domain

Size: 910 amino acids; 99712 Da

Subunit: Interacts with FADD and MAP-kinase activating death domain/MADD. Forms a complex with IKBKG and with

receptor-interacting serine-threonine kinase 1/RIP1. Forms also a complex named PIDDosome with CASP2 and CRADD

Subcellular location: Cytoplasm. Nucleus

Sequence caution: Sequence=BAD92069.1; Type=Erroneous initiation; Sequence=BAD92186.1; Type=Erroneous initiation;

Sequence=BAD92766.1; Type=Erroneous initiation; Sequence=CAD38708.1; Type=Erroneous initiation;

1 PDB 3D structure from and Proteopedia for PIDD:

2OF5 (3D)

Secondary accessions: Q59FD1 Q59H10 Q59HC7 Q7Z4P8 Q8NC89 Q8NDL2 Q96C25 Q9NRE6

Alternative splicing: 7 isoforms: Q9HB75-1 Q9HB75-2 Q9HB75-3 Q9HB75-4 Q9HB75-5 Q9HB75-6 Q9HB75-7

Explore the universe of human proteins at neXtProt for PIDD: NX_Q9HB75

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HB75

PIDD Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_665893.2 NP_665894.2

ENSEMBL proteins:

ENSP00000436342 ENSP00000436146 ENSP00000416801 ENSP00000337797 ENSP00000435008

Human Recombinant Protein Products:

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	Novus Biologicals PIDD Lysate
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PIDD

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IMP	--
GO:0005737	cytoplasm	IMP	--

PIDD for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for PIDD

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PIDD for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR001611 Leu-rich_rpt

IPR011029 DEATH-like_dom

IPR000906 ZU5

IPR003591 Leu-rich_rpt_typical-subtyp

IPR019502 Peptidase_S68_pidd

Graphical View of Domain Structure for InterPro Entry Q9HB75

ProtoNet protein and cluster: Q9HB75

1 Blocks protein family: IPB000488 Death domain

UniProtKB/Swiss-Prot: PIDD_HUMAN, Q9HB75

Similarity: Contains 1 death domain

Similarity: Contains 7 LRR (leucine-rich) repeats

Similarity: Contains 1 peptidase S68 domain

Similarity: Contains 2 ZU5 domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PIDD_HUMAN, Q9HB75

Function: Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway

that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination

of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates with

CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways

Induction: Induced by gamma-irradiation

miRNA Products:		OriGene 3'-UTR Clone (see all 3): PIDD Browse MicroRNA Expression Plasmids
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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PIDD
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIDD

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005123	death receptor binding	TAS	10825539
GO:0005515	protein binding	IPI	--

PIDD for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Lrdd^tm1.1Anvi for PIDD
     1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Lrdd):

normal

PIDD for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

p53 signaling pathway

p53 signaling pathway

1.00

DNA damage response

0.40

Apoptosis and survival_Apoptotic TNF-family pathways

Apoptosis Signaling Pathways

0.35

Apoptosis Modulation and Signaling

Apoptosis Modulation and Signaling

1.00

Direct p53 effectors

Direct p53 effectors

1.00

Apoptosis and survival_Caspase cascade

Caspase cascade in apoptosis

0.42

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for PIDD

Apoptosis Signaling Pathways

4 BioSystems Pathways for PIDD

	DNA damage response
	Apoptosis Modulation and Signaling
	Caspase cascade in apoptosis
	Direct p53 effectors

1 Kegg Pathway (Kegg details for PIDD):

p53 signaling pathway

PIDD for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PIDD

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/40 Interacting proteins for PIDD (Q9HB75^{1, 2, 3} ENSP00000337797⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 40)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CRADD	P78560¹^,²^,³, ENSP00000327647⁴	EBI-520427,EBI-520375 MINT-4054932 MINT-4054980 I2D: score=4 STRING: ENSP00000327647
CCDC85B	Q15834²^,³, ENSP00000311695⁴	MINT-68191 I2D: score=5 STRING: ENSP00000311695
EFEMP2	O95967²^,³, ENSP00000309953⁴	MINT-66608 I2D: score=4 STRING: ENSP00000309953
PRKDC	P78527¹^,³, ENSP00000313420⁴	EBI-520427,EBI-352053 I2D: score=1 STRING: ENSP00000313420
MDFI	Q99750¹^,²^,³, ENSP00000230321⁴	EBI-520427,EBI-724076 MINT-67603 I2D: score=5 STRING: ENSP00000230321

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	IEA	--
GO:0006974	response to DNA damage stimulus	IDA	--
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IMP	--
GO:0007165	signal transduction	TAS	10825539
GO:0043066	negative regulation of apoptotic process	IMP	--

PIDD for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PIDD
Search CenterWatch for drugs/clinical trials and news about PIDD

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PIDD gene (3 alternative transcripts):

NM_145886.3 NM_145887.3 NM_018494.3

Unigene Cluster for PIDD:

P53-induced death domain protein

Hs.592290 [show with all ESTs]

Unigene Representative Sequence: AB208949

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000525028 ENST00000524486(uc009yck.1 uc001lrl.1 uc001lrm.1)

ENST00000411829 ENST00000347755(uc001lrk.2 uc001lro.2 uc001lrn.2)

ENST00000531286 ENST00000527357(uc001lrp.2) ENST00000534525 ENST00000527812

ENST00000528122 ENST00000534649 ENST00000530911

miRNA Products:		OriGene 3'-UTR Clone (see all 3): PIDD Browse OriGene MicroRNA Expression Plasmids
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		GenScript Custom all cDNA clones Services for PIDD
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PIDD Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIDD

Additional cDNA sequence:

AB208949.1 AF229178.1 AF274972.1 BC014904.1

16 DOTS entries:

DT.95169519 DT.100785201 DT.120711455 DT.100785204 DT.310979 DT.92428086 DT.101983856 DT.120711483

DT.100025396 DT.92428083 DT.95366067 DT.92428087 DT.95177180 DT.102833869 DT.433630 DT.95366065

24/109 AceView cDNA sequences (see all 109):

BG820900 CD244581 BM765548 CK904475 BM068852 BI766625 AW300752 BM783215

AW450043 CD672628 AI674982 CB145597 BE884565 BM750094 BQ721262 BQ013382

BF902863 BQ214414 AI193673 AA377586 CF131984 AW293446 AI022161 CF528561

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PIDD (see all 10) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9	^	10a	·	10b	·	10c	^	11	^	12a	·	12b	^	13a	·	13b	^	14a	·
SP1:			-		-				-						-
SP2:															-																						-		-
SP3:									-						-																																		-
SP4:
SP5:																																							-										-

ExUns:	14b	^	15	^	16a	·	16b	·	16c
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for PIDD

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PIDD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCTTGGCCC

About this image

PIDD expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Diencephalon

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PIDD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PIDD

SOURCE GeneReport for Unigene cluster: Hs.592290

UniProtKB/Swiss-Prot: PIDD_HUMAN, Q9HB75

Tissue specificity: Ubiquitous

SABiosciences Expression via Pathway-Focused PCR Arrays including PIDD:

p53 Signaling Pathway in human mouse rat

Apoptosis 384HT in human mouse rat

Necrosis in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIDD

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PIDD gene from 7/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PIDD¹	p53-induced death domain protein	62.28(n) 57.97(a)		426464 XM_424108.3 XP_424108.3
lizard (Anolis carolinensis)	Reptilia	PIDD⁶	--	54(a)	1 ↔ 1	1(73762332-73781713)
zebrafish (Danio rerio)	Actinopterygii	pidd¹	p53-induced death domain protein	54.91(n) 50(a)		571033 XM_694585.4 XP_699677.4
honey bee (Apis mellifera)	Insecta	--	--	15(a)	possible ortholog	Group3.11(196300-198031)
worm (Caenorhabditis elegans)	Secernentea	C14F11.2⁶	Protein C14F11.2	10(a)	possible ortholog	X(6208731-6213876)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G07910⁶ AT2G30105⁶	uncharacterized protein	25(a) 15(a)	possible ortholog possible ortholog	5(2521534-2524201) 2(12849766-12852092)
rice (Oryza sativa)	Liliopsida	-- --	ubiquitin family protein, putative, expressed	25(a) 17(a)	possible ortholog possible ortholog	3(5852906-5856465) 10(16594587-16602237)

ENSEMBL Gene Tree for PIDD (if available)
TreeFam Gene Tree for PIDD (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PIDD gene

LRRC7² LRRC2² ERBB2IP² MFHAS1² LRRC18² LRRC30² LRRC1² LRRIQ4²

SCRIB² SHOC2² LRRD1² LRRC10B² LRRC39² LRRC40² LRRC10²

PIDD for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113279451^1,2		--	615903(+)	`CCCTCT/CGCCCT`	2	--	us2k¹		1		CSA	2
rs113383631^1,2	C,	--	615932(+)	`AACAAA/GTAAAT`	2	--	us2k¹		2		CSA WA	120
rs61740097^1,2	F	--	616196(+)	`ACTGCG/ACGCAC`	2	--	us2k¹		1		NS	54
rs186083132^1,2		--	798789(+)	`ACATGA/GTGAAA`	4	--	us2k¹ ds500¹		0	--	--	--	--
rs190936098^1,2		--	798812(+)	`AAAATA/GCAAAA`	4	--	ds500¹ us2k¹		0	--	--	--	--
rs149201289^1,2		--	798836(+)	`GTGGCA/GAGTGC`	4	--	ds500¹ us2k¹		0	--	--	--	--
rs182183454^1,2		--	798838(+)	`GGCAAA/GTGCCC`	4	--	ds500¹ us2k¹		0	--	--	--	--
rs114489794^1,2	F,	--	798840(+)	`CAAGTG/ACCCTA`	4	--	us2k¹ ds500¹		1		WA	118
rs12277141^1,2	C,F,H,	--	798865(+)	`AGAGGC/GTGACG`	4	--	ds500¹ us2k¹		17		NS EA NA WA CSA	791
rs143338496^1,2		--	798914(+)	`GCTGAA/GATCAT`	4	--	ds500¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PIDD (799179 - 809753 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PIDD: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PIDD for disorders           About GeneDecksing

OMIM gene information: 605247    OMIM disorders: --

5 diseases for PIDD:    About MalaCards

oral squamous cell carcinoma squamous cell carcinoma colon cancer lung cancer

carcinoma

1 Novoseek disease relationship for PIDD gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	1	15640352 (1)

Export disorders for PIDD gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PIDD gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with PIDD)

Utopia: connect your pdf to the dynamic
world of online information

LRDD, a novel leucine rich repeat and death domain containing protein. (PubMed id 10825539)^{1, 2, 3} Telliez J.-B.... Lin L.-L. (2000)
PIDD mediates NF-kappaB activation in response to DNA damage. (PubMed id 16360037)^{1, 2, 9} Janssens S.... Tschopp J. (2005)
Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. (PubMed id 16652156)^{1, 2, 9} Vakifahmetoglu H.... Zhivotovsky B. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The PIDDosome, a protein complex implicated in activation of caspase- 2 in response to genotoxic stress. (PubMed id 15073321)^{1, 2} Tinel A. and Tschopp J. (2004)
Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis. (PubMed id 10973264)^{1, 2} Lin Y.... Benchimol S. (2000)
Upon intracellular processing, the C-terminal death domain-containing fragment of the p53-inducible PIDD/LRDD protein translocates to the nucleoli and interacts with nucleolin. (PubMed id 16982033)^{1, 9} Pick R....Zornig M. (2006)
p53-induced protein with a death domain (PIDD) isoforms differentially activate nuclear factor-kappaB and caspase-2 in response to genotoxic stress. (PubMed id 17637755)^{1, 9} Cuenin S....Tschopp J. (2008)
PIDD death-domain phosphorylation by ATM controls prod eath versus prosurvival PIDDosome signaling. (PubMed id 22854598)¹ Ando K....Sidi S. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55367	HGNC: 16491	AceView: LRDD	Ensembl:ENSG00000177595	euGenes: HUgn55367
ECgene: PIDD	Kegg: 55367	H-InvDB: PIDD

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PIDD	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PIDD gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PIDD gene:
Search GeneIP for patents involving PIDD

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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