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Aliases for PID1 Gene

Aliases for PID1 Gene

  • Phosphotyrosine Interaction Domain Containing 1 2 3
  • Phosphotyrosine Interaction Domain-Containing Protein 1 3 4
  • NYGGF4 3 4
  • P-CLI1 3 4
  • PCLI1 3 4
  • Protein NYGGF4 4
  • HMFN2073 3

External Ids for PID1 Gene

Previous GeneCards Identifiers for PID1 Gene

  • GC02M229597
  • GC02M229888
  • GC02M221730
  • GC02M229715

Summaries for PID1 Gene

GeneCards Summary for PID1 Gene

PID1 (Phosphotyrosine Interaction Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PID1 Gene

  • Increases proliferation of preadipocytes without affecting adipocytic differentiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PID1 Gene

Genomics for PID1 Gene

Regulatory Elements for PID1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PID1 Gene

Chromosome:
2
Start:
228,850,526 bp from pter
End:
229,271,341 bp from pter
Size:
420,816 bases
Orientation:
Minus strand

Genomic View for PID1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PID1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PID1 Gene

Proteins for PID1 Gene

  • Protein details for PID1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z2X4-PCLI1_HUMAN
    Recommended name:
    PTB-containing, cubilin and LRP1-interacting protein
    Protein Accession:
    Q7Z2X4
    Secondary Accessions:
    • B3KU82
    • Q68CJ2
    • Q6ZUS3
    • Q8IXL0
    • Q9NWP6

    Protein attributes for PID1 Gene

    Size:
    250 amino acids
    Molecular mass:
    28272 Da
    Quaternary structure:
    • Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with LRP1 and CUBN.
    SequenceCaution:
    • Sequence=BAD38656.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PID1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PID1 Gene

Proteomics data for PID1 Gene at MOPED

Post-translational modifications for PID1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PID1 Gene

Antibody Products

No data available for DME Specific Peptides for PID1 Gene

Domains & Families for PID1 Gene

Protein Domains for PID1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PID1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z2X4

UniProtKB/Swiss-Prot:

PCLI1_HUMAN :
  • Contains 1 PID domain.
Domain:
  • Contains 1 PID domain.
genes like me logo Genes that share domains with PID1: view

No data available for Gene Families for PID1 Gene

Function for PID1 Gene

Molecular function for PID1 Gene

UniProtKB/Swiss-Prot Function:
Increases proliferation of preadipocytes without affecting adipocytic differentiation.
UniProtKB/Swiss-Prot Induction:
Up-regulated in fat of obese subjects.

Gene Ontology (GO) - Molecular Function for PID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PID1: view

Phenotypes for PID1 Gene

GenomeRNAi human phenotypes for PID1:
genes like me logo Genes that share phenotypes with PID1: view

Animal Model Products

miRNA for PID1 Gene

miRTarBase miRNAs that target PID1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PID1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PID1 Gene

Localization for PID1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PID1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PID1 Gene COMPARTMENTS Subcellular localization image for PID1 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 16815647
genes like me logo Genes that share ontologies with PID1: view

Pathways & Interactions for PID1 Gene

SuperPathways for PID1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IDA 19079291
GO:0006112 energy reserve metabolic process IC 20165904
GO:0010628 positive regulation of gene expression IMP 20165904
GO:0010635 regulation of mitochondrial fusion IC 20165904
GO:0044320 cellular response to leptin stimulus IEA --
genes like me logo Genes that share ontologies with PID1: view

No data available for Pathways by source and SIGNOR curated interactions for PID1 Gene

Drugs & Compounds for PID1 Gene

No Compound Related Data Available

Transcripts for PID1 Gene

Unigene Clusters for PID1 Gene

Phosphotyrosine interaction domain containing 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PID1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PID1 Gene

No ASD Table

Relevant External Links for PID1 Gene

GeneLoc Exon Structure for
PID1
ECgene alternative splicing isoforms for
PID1

Expression for PID1 Gene

mRNA expression in normal human tissues for PID1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PID1 Gene

This gene is overexpressed in Artery - Aorta (x4.4).

Protein differential expression in normal tissues from HIPED for PID1 Gene

This gene is overexpressed in Urinary Bladder (10.8), Gallbladder (9.4), Placenta (9.0), Pancreas (8.5), Prostate (7.9), Ovary (7.8), and Testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PID1 Gene



SOURCE GeneReport for Unigene cluster for PID1 Gene Hs.745038

mRNA Expression by UniProt/SwissProt for PID1 Gene

Q7Z2X4-PCLI1_HUMAN
Tissue specificity: Expressed in subcutaneous fat, heart, skeletal muscle, brain, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte.
genes like me logo Genes that share expression patterns with PID1: view

Protein tissue co-expression partners for PID1 Gene

Primer Products

In Situ Assay Products

Orthologs for PID1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PID1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PID1 36
  • 85 (a)
OneToOne
PID1 35
  • 99.6 (n)
  • 99.6 (a)
mouse
(Mus musculus)
Mammalia Pid1 36
  • 93 (a)
OneToOne
Pid1 16
Pid1 35
  • 88.68 (n)
  • 95.28 (a)
oppossum
(Monodelphis domestica)
Mammalia PID1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PID1 36
  • 99 (a)
OneToOne
PID1 35
  • 92.45 (n)
  • 97.64 (a)
cow
(Bos Taurus)
Mammalia PID1 36
  • 98 (a)
OneToOne
PID1 35
  • 92.78 (n)
  • 97.54 (a)
chicken
(Gallus gallus)
Aves PID1 36
  • 90 (a)
OneToOne
PID1 35
  • 81.13 (n)
  • 91.51 (a)
lizard
(Anolis carolinensis)
Reptilia PID1 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.103 35
pid1 35
  • 77.36 (n)
  • 88.68 (a)
zebrafish
(Danio rerio)
Actinopterygii pid1 36
  • 69 (a)
OneToOne
pid1 35
  • 71.92 (n)
  • 72.41 (a)
Species with no ortholog for PID1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PID1 Gene

ENSEMBL:
Gene Tree for PID1 (if available)
TreeFam:
Gene Tree for PID1 (if available)

Paralogs for PID1 Gene

(1) SIMAP similar genes for PID1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PID1: view

No data available for Paralogs for PID1 Gene

Variants for PID1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PID1 Gene

Q7Z2X4-PCLI1_HUMAN
Some sequences seem to have a duplication of exon 2

Sequence variations from dbSNP and Humsavar for PID1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1498 -- 229,141,130(+) GAAAT(A/G)AAATT intron-variant
rs10269 -- 229,024,381(-) AGAAT(G/T)AAATT utr-variant-3-prime
rs15339 -- 229,024,092(+) GAGTC(C/T)TCCTC utr-variant-3-prime
rs31274 -- 229,036,112(+) ATTGT(A/G)TATCA intron-variant
rs31275 -- 229,052,332(+) TTGCA(A/C)CAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PID1 Gene

Variant ID Type Subtype PubMed ID
nsv834563 CNV Gain 17160897
nsv3195 CNV Loss 18451855
nsv875936 CNV Gain 21882294
nsv3196 CNV Insertion 18451855
nsv875937 CNV Loss 21882294
esv2721579 CNV Deletion 23290073
esv2721580 CNV Deletion 23290073
esv2660840 CNV Deletion 23128226
esv2638269 CNV Deletion 19546169
dgv18e194 CNV Deletion 18987734
esv996239 CNV Deletion 20482838
esv2657525 CNV Deletion 23128226
esv2675408 CNV Deletion 23128226
nsv3197 CNV Loss 18451855
esv2404043 CNV Deletion 18987734
esv2721581 CNV Deletion 23290073
esv2721582 CNV Deletion 23290073
esv2721585 CNV Deletion 23290073
nsv507074 CNV Insertion 20534489
nsv875938 CNV Gain 21882294
esv2721586 CNV Deletion 23290073
esv1360518 CNV Deletion 17803354
esv2721587 CNV Deletion 23290073
nsv834564 CNV Gain 17160897
esv2721588 CNV Deletion 23290073
nsv523394 CNV Gain 19592680

Variation tolerance for PID1 Gene

Residual Variation Intolerance Score: 45.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 20.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PID1 Gene

HapMap Linkage Disequilibrium report
PID1
Human Gene Mutation Database (HGMD)
PID1

Disorders for PID1 Gene

Relevant External Links for PID1

Genetic Association Database (GAD)
PID1
Human Genome Epidemiology (HuGE) Navigator
PID1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PID1
genes like me logo Genes that share disorders with PID1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PID1 Gene

Publications for PID1 Gene

  1. Identification of the ligands of protein interaction domains through a functional approach. (PMID: 17124247) Caratu G. … Zambrano N. (Mol. Cell. Proteomics 2007) 2 67
  2. Identification and characterization of NYGGF4, a novel gene containing a phosphotyrosine-binding (PTB) domain that stimulates 3T3- L1 preadipocytes proliferation. (PMID: 16815647) Wang B. … Guo X.-R. (Gene 2006) 2 67
  3. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S. … Nakagawara A. (Oncogene 2004) 2 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas. (PMID: 24300787) Erdreich-Epstein A. … Asgharazadeh S. (Clin. Cancer Res. 2014) 67

Products for PID1 Gene

Sources for PID1 Gene

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