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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PICK1 Gene

protein-coding   GIFtS: 59
GCID: GC22P038452

protein interacting with PRKCA 1

(Previous names: protein kinase C, alpha binding protein, protein interacting...)
(Previous symbol: PRKCABP)
 Explore 15 diseases affiliated with
PICK1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PICK1    

Aliases
for PICK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Interacting With PRKCA 11 2     DJ1039K51
PRKCABP1 2 3 5     Protein Interacting With PRKCA1
Protein Interacting With C Kinase 12 3     Protein Kinase C, Alpha Binding Protein1
Protein Kinase C-Alpha-Binding Protein2 3     PICK2
MGC152041     PRKCA-Binding Protein2

External Ids:    HGNC: 93941   Entrez Gene: 94632   Ensembl: ENSG000001001517   OMIM: 6059265   UniProtKB: Q9NRD53   

Export aliases for PICK1 gene to outside databases

Previous GC identifers: GC22P036783 GC22P021417


Summaries
for PICK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PICK1:
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha
(PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety
of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma
membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins
and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein
that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the
same protein have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PICK1_HUMAN, Q9NRD5
Function: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane
proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting
at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and
internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3
channel

Gene Wiki entry for PICK1


Genomic Views
for PICK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PICK1 gene promoter:
         GR   Sp1   ATF-2   GR-beta   MyoD   LCR-F1   CRE-BP1   PPAR-gamma1   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PICK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PICK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PICK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

PICK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PICK1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P038452:  view genomic region     (about GC identifiers)

Start:
 38,452,318 bp from pter      End:
 38,471,708 bp from pter
Size:
 19,391 bases      Orientation:
 plus strand

Proteins
for PICK1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PICK1_HUMAN, Q9NRD5 (See protein sequence)
Recommended Name: PRKCA-binding protein  
Size: 415 amino acids; 46600 Da
Subunit: Monomer and homodimer. Interacts presynaptically with the monoamine transporters SLC6A2 and SLC6A3; with the
channel proteins ASIC1 and ASIC2; with the GTP-binding proteins ARF1 and ARF3. Interacts with PRKCA; with the ephrin
receptor tyrosine kinases EPHA7, EPHB1 and EPHB2; and with ERBB2. Interacts with BTG2; with the glutamate receptors
GRIA2, GRIA3, the isoform A of GRM4, GRM7 and GRM8; and with NAPA and NAPB. The interaction with NAPA and NAPB
disrupts the interaction with GRIA2, conducting to the internalization of GRIA2. Interacts with UNC5A (By similarity).
Interacts with CXADR. Interacts through its PDZ domain with the C-terminal tail of PRLHR. Interacts (via AH domain)
with NCS1/FREQ; in a calcium-dependent manner (By similarity)
Subcellular location: Cytoplasm, perinuclear region. Cell junction, synapse. Note=Also present at excitatory synapses
1 PDB 3D structure from and Proteopedia for PICK1:
2GZV (3D)    
Secondary accessions: O95906

Explore the universe of human proteins at neXtProt for PICK1: NX_Q9NRD5

Post-translational modifications:

  • Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NRD5

    • PICK1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001034672.1  NP_001034673.1  NP_036539.1  

    ENSEMBL proteins: 
     ENSP00000416487   ENSP00000385205   ENSP00000398141   ENSP00000410793   ENSP00000413962  
     ENSP00000349465   ENSP00000397588   ENSP00000387861  
    Reactome Protein details: Q9NRD5
    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 2): PICK1
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    Novus Biologicals PICK1 Proteins
    Novus Biologicals PICK1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PICK1

    Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA11343649
    GO:0005739mitochondrion IEA--
    GO:0005794Golgi apparatus ISS--
    GO:0005886plasma membrane TAS--
    GO:0014069postsynaptic density ----


    PICK1 for ontologies           About GeneDecksing



    PICK1 Antibody Products: 
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    Uscn Antibodies for PICK1
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    Assay Products for PICK1: 
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    Uscn ELISAs and CLIAs for PICK1

    Protein Domains /
    Families
    for PICK1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PICK1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001478 PDZ
     IPR010504 AH_dom

    Graphical View of Domain Structure for InterPro Entry Q9NRD5

    ProtoNet protein and cluster: Q9NRD5

    2 Blocks protein families:
    IPB001478 PDZ/DHR/GLGF domain
    IPB010504 Arfaptin-like


    UniProtKB/Swiss-Prot: PICK1_HUMAN, Q9NRD5
    Similarity: Contains 1 AH domain
    Similarity: Contains 1 PDZ (DHR) domain


    Function
    for PICK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PICK1_HUMAN, Q9NRD5
    Function: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane
    proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting
    at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and
    internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3
    channel

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): PICK1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PICK1
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate PICK1 (see all 9):
    hsa-miR-1321 hsa-miR-491-3p hsa-miR-650 hsa-miR-3142 hsa-miR-214 hsa-miR-532-3p hsa-miR-761 hsa-miR-3612
    SwitchGear 3'UTR luciferase reporter plasmid: PICK1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PICK1 (see all 7)
    OriGene shRNA RFP: PICK1
    OriGene siRNA: PICK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PICK1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PICK1

    Clone
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    Search LifeMap BioReagents cell lines for PICK1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PICK1

    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005080protein kinase C binding ISS--
    GO:0005102receptor binding ISS--
    GO:0005515protein binding IPI16713569
    GO:0008022protein C-terminus binding IPI11343649
    GO:0016887ATPase activity ISS--


    PICK1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for PICK1:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
         Mouse knock-out Pick1tm1Rlh for PICK1
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pick1):
     cellular  endocrine/exocrine gland  nervous system  reproductive system 

    PICK1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PICK1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transmission across Chemical Synapses
    		Transmission across Chemical Synapses1.00
    		Neuronal System0.67
    		Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    2Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
    		Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity1.00
    		Trafficking of GluR2-containing AMPA receptors0.53
    		Trafficking of AMPA receptors1.00
    3Synaptic transmission: ion currents
    		Synaptic transmission: ion currents1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for PICK1
        Synaptic transmission- ion currents


    5/6        Reactome Pathways for PICK1 (see all 6)
        Trafficking of AMPA receptors
    Transmission across Chemical Synapses
    Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
    Neuronal System
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell



    PICK1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PICK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/78 Interacting proteins for PICK1 (Q9NRD51, 2, 3 ENSP000003494654) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COILP384321, 2, 3, ENSP000002403164EBI-79165,EBI-945751 MINT-2866636 MINT-2866655 MINT-2866617 I2D: score=3 STRING: ENSP00000240316
    SLC6A3Q019592, 3, ENSP000002703494MINT-73279 MINT-73284 MINT-73280 MINT-73281 I2D: score=5 STRING: ENSP00000270349
    SLC6A2P239752, 3, ENSP000003692374MINT-73297 MINT-73299 MINT-73295 I2D: score=2 STRING: ENSP00000369237
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2866712 MINT-2866731 I2D: score=3 STRING: ENSP00000344782
    PRKCGP051292, 3, ENSP000002634314MINT-2866769 MINT-2866750 I2D: score=3 STRING: ENSP00000263431
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process ISS--
    GO:0006468protein phosphorylation ISS--
    GO:0006605protein targeting IEA--
    GO:0006890retrograde vesicle-mediated transport, Golgi to ER NAS10623590
    GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway IDA10623590


    PICK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PICK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PICK1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PICK1

    1 HMDB Compound for PICK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    8 Novoseek chemical compound relationships for PICK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 62.4 18 11144358 (2), 18077702 (2), 11466413 (2), 11641419 (1) (see all 12)
    nmda 51.7 12 16406232 (2), 18367088 (2), 19644508 (2), 18077702 (2) (see all 6)
    kainate 35.4 6 12597860 (2), 18692513 (2), 12941441 (1)
    dopamine 23.6 8 17606663 (2), 18411704 (1), 17266593 (1), 18466293 (1) (see all 6)
    lipid 4.46 16 17914463 (3), 16510715 (2), 18032668 (2), 17215589 (2) (see all 5)
    calcium 0 2 18353440 (1), 15190111 (1)
    tyrosine 0 2 17266593 (1), 15240807 (1)
    serine 0 4 16314870 (3)

    1 PharmGKB related drug/compound annotation for PICK1 gene
    Drug/compound PharmGKB Annotation
    methamphetamineCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about PICK1 

    Transcripts
    for PICK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PICK1 gene (3 alternative transcripts): 
    NM_001039583.1  NM_001039584.1  NM_012407.3  

    Unigene Cluster for PICK1:

    Protein interacting with PRKCA 1
    Hs.180871  [show with all ESTs]
    Unigene Representative Sequence: NM_012407
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000445628 ENST00000404072(uc003auq.3 uc003aur.3 uc003aus.3)
    ENST00000424694 ENST00000484021 ENST00000437453 ENST00000476157 ENST00000468288
    ENST00000426258 ENST00000469819 ENST00000356976(uc003aut.3) ENST00000466374
    ENST00000435166 ENST00000432756 ENST00000472724 ENST00000494434

    miRNA
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    hsa-miR-1321 hsa-miR-491-3p hsa-miR-650 hsa-miR-3142 hsa-miR-214 hsa-miR-532-3p hsa-miR-761 hsa-miR-3612
    SwitchGear 3'UTR luciferase reporter plasmid: PICK1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PICK1 (see all 7)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB026491.1 AF231710.1 AK000875.1 AK222640.1 AK308792.1 AK310629.1 AL049654.1 AL137355.1 
    BC017561.2 CR456550.1 

    13 DOTS entries:

    DT.75101687  DT.100789982  DT.75182388  DT.97841396  DT.100789984  DT.120660305  DT.100771422  DT.100789977 
    DT.120660237  DT.120660238  DT.120660243  DT.120660244  DT.102827618 

    24/137 AceView cDNA sequences (see all 137):

    NM_012407 BG681123 AU099301 BM800257 AX747747 BQ962710 CK431130 BQ440270 
    AL137355 AI560680 BE408986 CB113123 BQ018915 BI822139 CB151493 BM717306 
    AU105100 BQ439780 BP350355 AK092818 CB152372 BX119076 AK000875 AL079512 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for PICK1 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                -     -           -                       -           -                                   -                                 
    SP2:                                      -           -                       -           -                                   -                                 
    SP3:                          -     -     -           -                       -           -                                   -                                 
    SP4:                                      -           -                       -     -     -                                                                     
    SP5:                                      -           -     -     -           -     -     -                                                                     


    ECgene alternative splicing isoforms for PICK1

    Expression
    for PICK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PICK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCTGGGACC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See PICK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PICK1

    SOURCE GeneReport for Unigene cluster: Hs.180871

    UniProtKB/Swiss-Prot: PICK1_HUMAN, Q9NRD5
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including PICK1: 
              Synaptic Plasticity in human mouse rat

    Primer
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    Orthologs
    for PICK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PICK1 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Pick11 , 5 protein interacting with C kinase 11, 5 89.8(n)1
    96.63(a)1    		   15 (37.70 cM)5
    186931  NM_001045558.11  NP_001039023.11 
     792291735 
    chicken
    (Gallus gallus)    		 Aves PICK11 protein interacting with PRKCA 1 80.26(n)
    93.25(a)    		   418030  XM_416267.3  XP_416267.2 
    lizard
    (Anolis carolinensis)    		 Reptilia PICK16
    		 --
    		 90(a)
    		 1 ↔ 1
    		 GL343460.1(238347-252763)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.191622 Xenopus laevis transcribed sequence with moderate similarity more 77.91(n)    BI447955.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1532571 zgc:153257 75.66(n)
    82.43(a)    		   768194  NM_001077336.1  NP_001070804.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta PICK11 CG6167-PA 60.69(n)
    60.16(a)    		   34677  NM_135738.2  NP_609582.3 
    worm
    (Caenorhabditis elegans)    		 Secernentea CELE_Y57G11C.221 Protein Y57G11C.22 50.74(n)
    48.04(a)    		   178409  NM_001047581.1  NP_001041046.1 


    ENSEMBL Gene Tree for PICK1 (if available)
    TreeFam Gene Tree for PICK1 (if available) 

    Paralogs
    for PICK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for PICK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/360 NCBI SNPs in PICK1 are shown (see all 360)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1813051971,2
    		--38451262(+) AACAGG/TGGCAT 3 -- us2k10--------
    rs65190961,2
    		C,F,A,--38451389(+) TGTTTC/TTGAGA 3 -- us2k1 tfbs36Minor allele frequency- T:0.30NA WA EA 364
    rs718082421,2
    		C,--38451405(+) TCTGG-/CTCTGTC 3 -- us2k10--------
    rs1854289151,2
    		--38451405(+) TCTGGC/GTCTGT 3 -- us2k10--------
    rs1906905551,2
    		--38451434(+) ATGGCA/GCGATC 3 -- us2k10--------
    rs65190971,2
    		C,F,A,--38451465(+) CCACCC/TGGGTC 3 -- us2k15Minor allele frequency- T:0.28WA CSA NA EA 245
    rs1813764131,2
    		--38451475(+) CCAAGC/TGATTC 3 -- us2k10--------
    rs1872162831,2
    		--38451476(+) CAAGCA/GATTCT 3 -- us2k10--------
    rs81428871,2
    		C,F,A,--38451553(+) TTTTTG/AGTAGA 3 -- us2k13Minor allele frequency- A:0.33NA WA CSA 6
    rs768479461,2
    		C--38451751(+) CATTCA/TACACG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for PICK1 (38452318 - 38471708 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for PICK1
         2 CNVs: 5185 5186
    Human Gene Mutation Database (HGMD): PICK1

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    Disorders / Diseases
    for PICK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PICK1 for disorders           About GeneDecksing

    OMIM gene information: 605926    OMIM disorders: --

    15 diseases for PICK1:    About MalaCards
    gastroesophageal junction adenocarcinoma    substance dependence    globozoospermia    mutism
    male infertility    intrahepatic cholangiocarcinoma    pick's disease    infertility
    cholangiocarcinoma    schizophrenia    breast cancer    ataxia
    cerebritis    adenocarcinoma    neuronitis

    1 Novoseek disease relationship for PICK1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 26.4 17 17367885 (5), 15305146 (3), 17011050 (2), 16983646 (1) (see all 7)

    Human Genome Epidemiology (HuGE) Navigator: PICK1 (7 documents)

    Export disorders for PICK1 gene to outside databases

    Publications
    for PICK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PICK1 gene, integrated from 9 sources (see all 115):
    (articles sorted by number of sources associating them with PICK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I....O'Brien K.P. (1999)
    2. Interaction of the PDZ domain of human PICK1 with class I ADP- ribosylation factors. (PubMed id 10623590)1, 2, 9 Takeya R.... Sumimoto H. (2000)
    3. Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. (PubMed id 11343649)1, 2, 9 Torres G.E.... Caron M.G. (2001)
    4. The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy- 5-methylisoxazole-4-propionic acid receptor clustering. (PubMed id 11641419)1, 2, 9 Lin S.H.S.... Civelli O. (2001)
    5. A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth. (PubMed id 15304526)1, 2, 9 Ashbourne-Excoffon K.J.D....Zabner J. (2004)
    6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PubMed id 12529303)1, 2 Collins J.E.... Dunham I. (2003)
    9. Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel). (PubMed id 11802773)1, 2 Hruska-Hageman A.M.... Welsh M.J. (2002)
    10. The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits. (PubMed id 10340301)1, 3 Dev K.K....Nakanishi S. (1999)

    External Searches for PICK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PICK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9463 HGNC: 9394 AceView: PRKCABP Ensembl:ENSG00000100151 euGenes: HUgn9463
    ECgene: PICK1 H-InvDB: PICK1

    Other Databases showing PICK1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PICK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PICK1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PICK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PICK1 gene:
    Search GeneIP for patents involving PICK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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