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Aliases for PICK1 Gene

Aliases for PICK1 Gene

  • Protein Interacting With PRKCA 1 2 3
  • PRKCABP 3 4 6
  • Protein Kinase C-Alpha-Binding Protein 3 4
  • Protein Interacting With C Kinase 1 3 4
  • Protein Kinase C, Alpha Binding Protein 2
  • Protein Interacting With PRKCA 2
  • PRKCA-Binding Protein 3
  • PICK 3

External Ids for PICK1 Gene

Previous HGNC Symbols for PICK1 Gene

  • PRKCABP

Previous GeneCards Identifiers for PICK1 Gene

  • GC22P036783
  • GC22P038452
  • GC22P021417

Summaries for PICK1 Gene

Entrez Gene Summary for PICK1 Gene

  • The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PICK1 Gene

PICK1 (Protein Interacting With PRKCA 1) is a Protein Coding gene. Diseases associated with PICK1 include central nervous system disease and nervous system disease. Among its related pathways are Transmission across Chemical Synapses and Transmission across Chemical Synapses. GO annotations related to this gene include receptor binding and protein C-terminus binding.

UniProtKB/Swiss-Prot for PICK1 Gene

  • Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.

Gene Wiki entry for PICK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PICK1 Gene

Genomics for PICK1 Gene

Regulatory Elements for PICK1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PICK1 Gene

Start:
38,056,311 bp from pter
End:
38,075,701 bp from pter
Size:
19,391 bases
Orientation:
Plus strand

Genomic View for PICK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PICK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PICK1 Gene

Proteins for PICK1 Gene

  • Protein details for PICK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRD5-PICK1_HUMAN
    Recommended name:
    PRKCA-binding protein
    Protein Accession:
    Q9NRD5
    Secondary Accessions:
    • B3KS52
    • O95906

    Protein attributes for PICK1 Gene

    Size:
    415 amino acids
    Molecular mass:
    46600 Da
    Quaternary structure:
    • Monomer and homodimer. Interacts with CXADR. Interacts presynaptically with the glutamate receptors GRIA2, GRIA3, GRIK3, isoform 3 of GRIA4, isoform A of GRM4, GRM7 and GRM8; with NAPA and NAPB; and with BTG2. The interaction with NAPA and NAPB disrupts the interaction with GRIA2, conducting to the internalization of GRIA2. Interacts with PRKCA; with the amine transporters SLC6A2 and SLC6A3; with the channels ASIC1 and ASIC2; with the GTP-binding proteins ARF1 and ARF3; with the ephrin receptor tyrosine kinases EPHA7, EPHB1 and EPHB2; with ERBB2 and through its PDZ domain with the C-terminal tail of PRLHR. Interacts with UNC5A. Interacts (via AH domain) with NCS1/FREQ; in a calcium-dependent manner. Interacts with F-actin and associates with the ARP2/3 complex. Interacts (via PDZ domain) with ARF1 (activated); the interaction blocks Arp2/3 complex inhibition.

    Three dimensional structures from OCA and Proteopedia for PICK1 Gene

    Alternative splice isoforms for PICK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PICK1 Gene

Proteomics data for PICK1 Gene at MOPED

Post-translational modifications for PICK1 Gene

  • Palmitoylation on Cys-413 is essential for long-term synaptic depression (LTD).
  • Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors.
  • Ubiquitination at Lys209
  • Modification sites at PhosphoSitePlus

Other Protein References for PICK1 Gene

Antibody Products

No data available for DME Specific Peptides for PICK1 Gene

Domains for PICK1 Gene

Protein Domains for PICK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NRD5

UniProtKB/Swiss-Prot:

PICK1_HUMAN :
  • Q9NRD5
Domain:
  • The AH domain mediates binding to F-actin.
  • The unoccupied PDZ domain is probably involved in allosteric modulation by forming an intramolecular bridge with the AH domain leading to a closed formation. Binding of a PDZ ligand, such as GRIA2, allows enhanced interactions with F-actin and the Arp2/3 complex thus enhanced inhibition of actin polymerization (By similarity).
  • Contains 1 AH domain.
  • Contains 1 PDZ (DHR) domain.
genes like me logo Genes that share domains with PICK1: view

No data available for Gene Families for PICK1 Gene

Function for PICK1 Gene

Molecular function for PICK1 Gene

UniProtKB/Swiss-Prot Function: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.

Gene Ontology (GO) - Molecular Function for PICK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding ISS --
GO:0005080 protein kinase C binding ISS --
GO:0005102 receptor binding ISS --
GO:0005515 protein binding IPI 11802773
GO:0008022 protein C-terminus binding IPI 11343649
genes like me logo Genes that share ontologies with PICK1: view
genes like me logo Genes that share phenotypes with PICK1: view

Animal Models for PICK1 Gene

MGI Knock Outs for PICK1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PICK1 Gene

Localization for PICK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PICK1 Gene

Cytoplasm, perinuclear region. Membrane; Peripheral membrane protein. Membrane; Lipid-anchor. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse, synaptosome. Cytoplasm, cytoskeleton. Note=Also membrane-associated, present at excitatory synapses. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PICK1 Gene COMPARTMENTS Subcellular localization image for PICK1 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
cytosol 2
mitochondrion 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PICK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11343649
GO:0005739 mitochondrion IEA --
GO:0005794 Golgi apparatus ISS --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with PICK1: view

Pathways for PICK1 Gene

genes like me logo Genes that share pathways with PICK1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PICK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002092 positive regulation of receptor internalization ISS --
GO:0006200 obsolete ATP catabolic process --
GO:0006468 protein phosphorylation ISS --
GO:0006605 protein targeting IEA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER NAS 10623590
genes like me logo Genes that share ontologies with PICK1: view

Compounds for PICK1 Gene

(1) HMDB Compounds for PICK1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(8) Novoseek inferred chemical compound relationships for PICK1 Gene

Compound -log(P) Hits PubMed IDs
glutamate 62.4 15
nmda 51.7 10
kainate 35.4 5
dopamine 23.6 7
lipid 4.46 10

(1) PharmGKB related drug/compound annotations for PICK1 Gene

Drug/compound Annotation
methamphetamine CA
genes like me logo Genes that share compounds with PICK1: view

Transcripts for PICK1 Gene

Unigene Clusters for PICK1 Gene

Protein interacting with PRKCA 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PICK1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PICK1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PICK1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: - - -
SP7: -
SP8: - - - - -
SP9: - -
SP10: - - - - -
SP11: - -
SP12: -

Relevant External Links for PICK1 Gene

GeneLoc Exon Structure for
PICK1
ECgene alternative splicing isoforms for
PICK1

Expression for PICK1 Gene

mRNA expression in normal human tissues for PICK1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PICK1 Gene

SOURCE GeneReport for Unigene cluster for PICK1 Gene Hs.180871

mRNA Expression by UniProt/SwissProt for PICK1 Gene

Q9NRD5-PICK1_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with PICK1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PICK1 Gene

Orthologs for PICK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PICK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PICK1 35
  • 99.52 (n)
  • 99.76 (a)
PICK1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PICK1 35
  • 92.76 (n)
  • 99.01 (a)
PRKCABP 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PICK1 35
  • 91.73 (n)
  • 96.87 (a)
PICK1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pick1 35
  • 89.16 (n)
  • 95.66 (a)
Pick1 16
Pick1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PICK1 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PICK1 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pick1 35
  • 89 (n)
  • 96.39 (a)
chicken
(Gallus gallus)
Aves PICK1 35
  • 80.82 (n)
  • 94.62 (a)
PICK1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PICK1 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19162 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pick1 35
  • 75.88 (n)
  • 88.83 (a)
Str.5642 35
zebrafish
(Danio rerio)
Actinopterygii pick1 35
  • 78.08 (n)
  • 87.33 (a)
pick1 36
  • 82 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007832 35
  • 62.75 (n)
  • 62.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta PICK1 35
  • 60.84 (n)
  • 60.93 (a)
PICK1 36
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_Y57G11C.22 35
  • 51.23 (n)
  • 49.04 (a)
Y57G11C.22 36
  • 42 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14348 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 67 (a)
OneToOne
Species with no ortholog for PICK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PICK1 Gene

ENSEMBL:
Gene Tree for PICK1 (if available)
TreeFam:
Gene Tree for PICK1 (if available)

Paralogs for PICK1 Gene

No data available for Paralogs for PICK1 Gene

Variants for PICK1 Gene

Sequence variations from dbSNP and Humsavar for PICK1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs3948 -- 38,060,673(+) GCTCA(A/G)CCTCT intron-variant
rs3952 -- 38,060,591(+) CCTTC(A/G)TGAGC intron-variant
rs713729 -- 38,059,462(+) CCCTC(A/T)CAGAG intron-variant
rs737662 -- 38,056,358(+) CCGGC(C/G)GTGGG upstream-variant-2KB
rs738441 -- 38,061,295(+) GAGAT(C/T)GTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PICK1 Gene

Variant ID Type Subtype PubMed ID
nsv915035 CNV Loss 21882294
nsv915053 CNV Loss 21882294
nsv834193 CNV Loss 17160897
nsv915054 CNV Loss 21882294
dgv4968n71 CNV Loss 21882294
nsv471198 CNV Loss 18288195
dgv4969n71 CNV Loss 21882294
nsv834194 CNV Loss 17160897

Relevant External Links for PICK1 Gene

HapMap Linkage Disequilibrium report
PICK1
Human Gene Mutation Database (HGMD)
PICK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PICK1 Gene

Disorders for PICK1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for PICK1 Gene including...

Search for PICK1 Gene in MalaCards »

(1) Novoseek inferred disease relationships for PICK1 Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 26.4 14

Relevant External Links for PICK1

Genetic Association Database (GAD)
PICK1
Human Genome Epidemiology (HuGE) Navigator
PICK1
genes like me logo Genes that share disorders with PICK1: view

No data available for UniProtKB/Swiss-Prot for PICK1 Gene

Publications for PICK1 Gene

  1. Interaction of the PDZ domain of human PICK1 with class I ADP- ribosylation factors. (PMID: 10623590) Takeya R. … Sumimoto H. (Biochem. Biophys. Res. Commun. 2000) 3 4 23
  2. Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. (PMID: 11343649) Torres G.E. … Caron M.G. (Neuron 2001) 3 4 23
  3. The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy- 5-methylisoxazole-4-propionic acid receptor clustering. (PMID: 11641419) Lin S.H.S. … Civelli O. (Mol. Pharmacol. 2001) 3 4 23
  4. A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth. (PMID: 15304526) Ashbourne-Excoffon K.J.D. … Zabner J. (J. Cell Sci. 2004) 3 4 23
  5. PICK1 is not a susceptibility gene for schizophrenia in a Japanese population: association study in a large case-control population. (PMID: 17367885) Ishiguro H. … Arinami T. (Neurosci. Res. 2007) 3 23 48

Products for PICK1 Gene

Sources for PICK1 Gene

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