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Aliases for PICK1 Gene

Aliases for PICK1 Gene

  • Protein Interacting With PRKCA 1 2 3 5
  • Protein Kinase C-Alpha-Binding Protein 3 4
  • Protein Interacting With C Kinase 1 3 4
  • PRKCABP 3 4
  • Protein Kinase C, Alpha Binding Protein 2
  • Protein Interacting With PRKCA 2
  • PRKCA-Binding Protein 3
  • PICK 3

External Ids for PICK1 Gene

Previous HGNC Symbols for PICK1 Gene

  • PRKCABP

Previous GeneCards Identifiers for PICK1 Gene

  • GC22P036783
  • GC22P038452
  • GC22P021417

Summaries for PICK1 Gene

Entrez Gene Summary for PICK1 Gene

  • The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PICK1 Gene

PICK1 (Protein Interacting With PRKCA 1) is a Protein Coding gene. Diseases associated with PICK1 include Spermatogenic Failure 6 and Schizophrenia. Among its related pathways are Neuroscience and Trafficking of AMPA receptors. GO annotations related to this gene include identical protein binding and enzyme binding.

UniProtKB/Swiss-Prot for PICK1 Gene

  • Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.

Gene Wiki entry for PICK1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PICK1 Gene

Genomics for PICK1 Gene

Regulatory Elements for PICK1 Gene

Enhancers for PICK1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G038056 1.3 ENCODE dbSUPER 24.2 +1.0 1031 1.8 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 SP3 ZHX2 PICK1 ENSG00000233739
GH22G038065 1.1 dbSUPER 22.5 +10.2 10245 1.6 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF263 SP3 MXD4 PICK1 BAIAP2L2 ENSG00000233739
GH22G038087 0.8 Ensembl 24.6 +32.5 32511 2.5 ZMYM3 ZKSCAN1 ZFHX2 FOXK2 POLR2A PATZ1 PRDM10 EGR2 ZNF263 PAF1 BAIAP2L2 PICK1 PLA2G6 TMEM184B ENSG00000272720 SLC16A8
GH22G038309 1.8 FANTOM5 ENCODE dbSUPER 10.9 +257.9 257926 11.9 MLX CREB3L1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TMEM184B PICK1 MAFF KCNJ4 KDELR3 SOX10 POLR2F PDXP GGA1 SUN2
GH22G038294 1.7 Ensembl ENCODE dbSUPER 11 +244.6 244632 12.5 CREB3L1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF416 ZNF263 SP3 TBX21 CBX7 ENSG00000230149 CBX6 ENSG00000273076 NPTXR TMEM184B ENSG00000272669 ENSG00000225450 APOBEC3D PRDX3P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PICK1 on UCSC Golden Path with GeneCards custom track

Promoters for PICK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000146108 1189 1001 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 SP3 ZHX2

Genomic Location for PICK1 Gene

Chromosome:
22
Start:
38,056,311 bp from pter
End:
38,075,701 bp from pter
Size:
19,391 bases
Orientation:
Plus strand

Genomic View for PICK1 Gene

Genes around PICK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PICK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PICK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PICK1 Gene

Proteins for PICK1 Gene

  • Protein details for PICK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRD5-PICK1_HUMAN
    Recommended name:
    PRKCA-binding protein
    Protein Accession:
    Q9NRD5
    Secondary Accessions:
    • B3KS52
    • O95906

    Protein attributes for PICK1 Gene

    Size:
    415 amino acids
    Molecular mass:
    46600 Da
    Quaternary structure:
    • Monomer and homodimer. Interacts with CXADR. Interacts presynaptically with the glutamate receptors GRIA2, GRIA3, GRIK3, isoform 3 of GRIA4, isoform A of GRM4, GRM7 and GRM8; with NAPA and NAPB; and with BTG2. The interaction with NAPA and NAPB disrupts the interaction with GRIA2, conducting to the internalization of GRIA2. Interacts with PRKCA; with the amine transporters SLC6A2 and SLC6A3; with the channels ASIC1 and ASIC2; with the GTP-binding proteins ARF1 and ARF3; with the ephrin receptor tyrosine kinases EPHA7, EPHB1 and EPHB2; with ERBB2 and through its PDZ domain with the C-terminal tail of PRLHR. Interacts with UNC5A. Interacts (via AH domain) with NCS1/FREQ; in a calcium-dependent manner. Interacts with F-actin and associates with the ARP2/3 complex. Interacts (via PDZ domain) with ARF1 (activated); the interaction blocks Arp2/3 complex inhibition.

    Three dimensional structures from OCA and Proteopedia for PICK1 Gene

    Alternative splice isoforms for PICK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PICK1 Gene

Post-translational modifications for PICK1 Gene

  • Palmitoylation on Cys-413 is essential for long-term synaptic depression (LTD).
  • Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors.
  • Ubiquitination at posLast=209209
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PICK1 (PICK1)

No data available for DME Specific Peptides for PICK1 Gene

Domains & Families for PICK1 Gene

Protein Domains for PICK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NRD5

UniProtKB/Swiss-Prot:

PICK1_HUMAN :
  • The AH domain mediates binding to F-actin.
Domain:
  • The AH domain mediates binding to F-actin.
  • The unoccupied PDZ domain is probably involved in allosteric modulation by forming an intramolecular bridge with the AH domain leading to a closed formation. Binding of a PDZ ligand, such as GRIA2, allows enhanced interactions with F-actin and the Arp2/3 complex thus enhanced inhibition of actin polymerization (By similarity).
genes like me logo Genes that share domains with PICK1: view

Function for PICK1 Gene

Molecular function for PICK1 Gene

UniProtKB/Swiss-Prot Function:
Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.

Gene Ontology (GO) - Molecular Function for PICK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding ISS --
GO:0003779 actin binding IEA --
GO:0005080 protein kinase C binding ISS --
GO:0005102 receptor binding ISS --
GO:0005515 protein binding IPI 11802773
genes like me logo Genes that share ontologies with PICK1: view
genes like me logo Genes that share phenotypes with PICK1: view

Animal Models for PICK1 Gene

MGI Knock Outs for PICK1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PICK1 Gene

Localization for PICK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PICK1 Gene

Cytoplasm, perinuclear region. Membrane; Peripheral membrane protein. Membrane; Lipid-anchor. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse, synaptosome. Cytoplasm, cytoskeleton. Note=Also membrane-associated, present at excitatory synapses. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PICK1 gene
Compartment Confidence
plasma membrane 5
mitochondrion 5
cytosol 5
golgi apparatus 5
cytoskeleton 3
nucleus 3
endosome 1

Gene Ontology (GO) - Cellular Components for PICK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 11343649
GO:0005739 mitochondrion IDA --
GO:0005794 Golgi apparatus ISS --
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with PICK1: view

Pathways & Interactions for PICK1 Gene

genes like me logo Genes that share pathways with PICK1: view

Gene Ontology (GO) - Biological Process for PICK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002092 positive regulation of receptor internalization ISS --
GO:0006468 protein phosphorylation ISS --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER NAS 10623590
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IDA 10623590
GO:0015844 monoamine transport IDA 11343649
genes like me logo Genes that share ontologies with PICK1: view

No data available for SIGNOR curated interactions for PICK1 Gene

Drugs & Compounds for PICK1 Gene

(8) Drugs for PICK1 Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methamphetamine Approved, Illicit Pharma 245
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for PICK1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PICK1: view

Transcripts for PICK1 Gene

Unigene Clusters for PICK1 Gene

Protein interacting with PRKCA 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PICK1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: - - -
SP7: -
SP8: - - - - -
SP9: - -
SP10: - - - - -
SP11: - -
SP12: -

Relevant External Links for PICK1 Gene

GeneLoc Exon Structure for
PICK1
ECgene alternative splicing isoforms for
PICK1

Expression for PICK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PICK1 Gene

Protein differential expression in normal tissues from HIPED for PICK1 Gene

This gene is overexpressed in Frontal cortex (22.5), Fetal Brain (12.3), and Pancreatic juice (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PICK1 Gene



NURSA nuclear receptor signaling pathways regulating expression of PICK1 Gene:

PICK1

SOURCE GeneReport for Unigene cluster for PICK1 Gene:

Hs.180871

mRNA Expression by UniProt/SwissProt for PICK1 Gene:

Q9NRD5-PICK1_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for PICK1 Gene

  • Nervous system(4.7)
  • Skin(4.4)
  • Intestine(4.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PICK1 Gene

Germ Layers:
  • mesoderm
Systems:
  • reproductive
Organs:
Pelvis:
  • ovary
  • testicle
genes like me logo Genes that share expression patterns with PICK1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for PICK1 Gene

Orthologs for PICK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PICK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PICK1 34 35
  • 99.52 (n)
cow
(Bos Taurus)
Mammalia PRKCABP 35
  • 97 (a)
OneToOne
PICK1 34
  • 92.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PICK1 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PICK1 34 35
  • 91.73 (n)
mouse
(Mus musculus)
Mammalia Pick1 34 16 35
  • 89.16 (n)
rat
(Rattus norvegicus)
Mammalia Pick1 34
  • 89 (n)
oppossum
(Monodelphis domestica)
Mammalia PICK1 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves PICK1 34 35
  • 80.82 (n)
lizard
(Anolis carolinensis)
Reptilia PICK1 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pick1 34
  • 75.88 (n)
Str.5642 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.19162 34
zebrafish
(Danio rerio)
Actinopterygii pick1 34 35
  • 78.08 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007832 34
  • 62.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta PICK1 34 35
  • 60.84 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y57G11C.22 34
  • 51.23 (n)
Y57G11C.22 35
  • 42 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 67 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14348 34
Species where no ortholog for PICK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PICK1 Gene

ENSEMBL:
Gene Tree for PICK1 (if available)
TreeFam:
Gene Tree for PICK1 (if available)

Paralogs for PICK1 Gene

No data available for Paralogs for PICK1 Gene

Variants for PICK1 Gene

Sequence variations from dbSNP and Humsavar for PICK1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000186760 -- 38,071,832(+) ACAGC(A/G)CCTGA intron-variant
rs1000351488 -- 38,054,932(+) GAAAA(G/T)AAAAG upstream-variant-2KB
rs1000382147 -- 38,066,073(+) TGCTG(A/T)AGGAA intron-variant
rs1000392814 -- 38,060,852(+) CAAAC(A/C/G)ATTCT intron-variant
rs1000444976 -- 38,060,532(+) GGCCT(C/T)GAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PICK1 Gene

Variant ID Type Subtype PubMed ID
nsv471198 CNV loss 18288195
nsv834193 CNV loss 17160897
nsv834194 CNV loss 17160897

Variation tolerance for PICK1 Gene

Residual Variation Intolerance Score: 13.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PICK1 Gene

Human Gene Mutation Database (HGMD)
PICK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PICK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PICK1 Gene

Disorders for PICK1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PICK1 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
spermatogenic failure 6
  • spermatogenic failure 9
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search PICK1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PICK1

Genetic Association Database (GAD)
PICK1
Human Genome Epidemiology (HuGE) Navigator
PICK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PICK1
genes like me logo Genes that share disorders with PICK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PICK1 Gene

Publications for PICK1 Gene

  1. Genetic association studies of methamphetamine use disorders: A systematic review and synthesis. (PMID: 19219857) Bousman C.A. … Tsuang M.T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 22 46 64
  2. PICK1 is not a susceptibility gene for schizophrenia in a Japanese population: association study in a large case-control population. (PMID: 17367885) Ishiguro H. … Arinami T. (Neurosci. Res. 2007) 3 22 46 64
  3. Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis. (PMID: 17606663) Matsuzawa D. … Iyo M. (Am J Psychiatry 2007) 3 22 46 64
  4. A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth. (PMID: 15304526) Ashbourne-Excoffon K.J.D. … Zabner J. (J. Cell Sci. 2004) 3 4 22 64
  5. Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. (PMID: 11343649) Torres G.E. … Caron M.G. (Neuron 2001) 3 4 22 64

Products for PICK1 Gene

Sources for PICK1 Gene

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