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PICK1 Gene

protein-coding   GIFtS: 59
GCID: GC22P038452

Protein Interacting With PRKCA 1

(Previous names: protein kinase C, alpha binding protein, protein interacting...)
(Previous symbol: PRKCABP)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Interacting With PRKCA 11 2     Protein Interacting With PRKCA1
PRKCABP1 2 3 5     Protein Kinase C, Alpha Binding Protein1
Protein Interacting With C Kinase 12 3     PICK2
Protein Kinase C-Alpha-Binding Protein2 3     PRKCA-Binding Protein2

External Ids:    HGNC: 93941   Entrez Gene: 94632   Ensembl: ENSG000001001517   OMIM: 6059265   UniProtKB: Q9NRD53   

Export aliases for PICK1 gene to outside databases

Previous GC identifers: GC22P036783 GC22P021417


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PICK1 Gene:
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha
(PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a
variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine
plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these
membrane proteins and thus regulate their distribution and function. This protein has also been found to act as
an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three
transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PICK1 Gene:
PICK1 (protein interacting with PRKCA 1) is a protein-coding gene. Diseases associated with PICK1 include gastroesophageal junction adenocarcinoma, and globozoospermia. GO annotations related to this gene include protein C-terminus binding and receptor binding.

UniProtKB/Swiss-Prot: PICK1_HUMAN, Q9NRD5
Function: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane
proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by
acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking
and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel.
Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is
competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor
(AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of
excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of
astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function

Gene Wiki entry for PICK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PICK1 gene promoter:
         GR   Sp1   ATF-2   GR-beta   MyoD   LCR-F1   CRE-BP1   PPAR-gamma1   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPICK1 promoter sequence
   Search Chromatin IP Primers for PICK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PICK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

PICK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PICK1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P038452:  view genomic region     (about GC identifiers)

Start:
38,452,318 bp from pter      End:
38,471,708 bp from pter
Size:
19,391 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PICK1_HUMAN, Q9NRD5 (See protein sequence)
Recommended Name: PRKCA-binding protein  
Size: 415 amino acids; 46600 Da
Subunit: Monomer and homodimer. Interacts with CXADR. Interacts presynaptically with the glutamate receptors
GRIA2, GRIA3, GRIK3, isoform 3 of GRIA4, isoform A of GRM4, GRM7 and GRM8; with NAPA and NAPB; and with BTG2. The
interaction with NAPA and NAPB disrupts the interaction with GRIA2, conducting to the internalization of GRIA2.
Interacts with PRKCA; with the amine transporters SLC6A2 and SLC6A3; with the channels ASIC1 and ASIC2; with the
GTP-binding proteins ARF1 and ARF3; with the ephrin receptor tyrosine kinases EPHA7, EPHB1 and EPHB2; with ERBB2
and through its PDZ domain with the C-terminal tail of PRLHR. Interacts with UNC5A. Interacts (via AH domain)
with NCS1/FREQ; in a calcium-dependent manner. Interacts with F-actin and associates with the ARP2/3 complex.
Interacts (via PDZ domain) with ARF1 (activated); the interaction blocks Arp2/3 complex inhibition
1 PDB 3D structure from and Proteopedia for PICK1:
2GZV (3D)    
Secondary accessions: O95906

Explore the universe of human proteins at neXtProt for PICK1: NX_Q9NRD5

Explore proteomics data for PICK1 at MOPED

Post-translational modifications: 

  • Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors1
  • Ubiquitination2 at Lys209
  • Modification sites at PhosphoSitePlus

  • See PICK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001034672.1  NP_001034673.1  NP_036539.1  

    ENSEMBL proteins: 
     ENSP00000416487   ENSP00000385205   ENSP00000398141   ENSP00000410793   ENSP00000413962  
     ENSP00000349465   ENSP00000397588   ENSP00000387861  
    Reactome Protein details: Q9NRD5

    PICK1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Proteins for PICK1
    OriGene Protein Over-expression Lysate for PICK1
    OriGene MassSpec for PICK1
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    GenScript Custom Purified and Recombinant Proteins Services for PICK1
    Novus Biologicals PICK1 Proteins
    Novus Biologicals PICK1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PICK1

    PICK1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PICK1
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    Novus Biologicals PICK1 Antibodies
    Abcam antibodies for PICK1
    Cloud-Clone Corp. Antibodies for PICK1
    ThermoFisher Antibodies for PICK1
    LSBio Antibodies in human, mouse, rat for PICK1

    PICK1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PICK1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PICK1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PICK1
    Cloud-Clone Corp. CLIAs for PICK1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR027267 AH/BAR-dom
     IPR001478 PDZ
     IPR010504 AH_dom

    Graphical View of Domain Structure for InterPro Entry Q9NRD5

    ProtoNet protein and cluster: Q9NRD5

    2 Blocks protein domains:
    IPB001478 PDZ/DHR/GLGF domain
    IPB010504 Arfaptin-like


    UniProtKB/Swiss-Prot: PICK1_HUMAN, Q9NRD5
    Domain: The AH domain mediates binding to F-actin (By similarity)
    Domain: The unoccupied PDZ domain is probably involved in allosteric modulation by forming an intramolecular
    bridge with the AH domain leading to a 'closed' formation. Binding of a PDZ ligand, such as GRIA2, allows
    enhanced interactions with F-actin and the Arp2/3 complex thus enhanced inhibition of actin polymerization (By
    similarity)
    Similarity: Contains 1 AH domain
    Similarity: Contains 1 PDZ (DHR) domain


    PICK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PICK1_HUMAN, Q9NRD5
    Function: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane
    proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by
    acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking
    and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel.
    Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is
    competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor
    (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of
    excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of
    astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005080protein kinase C binding ISS--
    GO:0005102receptor binding ISS--
    GO:0005515protein binding IPI11802773
    GO:0008022protein C-terminus binding IPI11343649
    GO:0016887ATPase activity ISS--
         
    PICK1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PICK1:
     G0/1 arrest  Increased G1 DNA content 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pick1):
     cellular  endocrine/exocrine gland  nervous system  reproductive system 

    PICK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pick1tm1Rlh for PICK1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PICK1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PICK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PICK1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PICK1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat PICK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PICK1 (see all 9):
    hsa-miR-1321 hsa-miR-491-3p hsa-miR-650 hsa-miR-3142 hsa-miR-214 hsa-miR-532-3p hsa-miR-761 hsa-miR-3612
    SwitchGear 3'UTR luciferase reporter plasmidPICK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PICK1
    Predesigned siRNA for gene silencing in human, mouse, rat PICK1

    Gene Editing
    Products:
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    Clone
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    OriGene clones in human, mouse for PICK1 (see all 18)
    OriGene ORF clones in mouse, rat for PICK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PICK1 (NM_001039583)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PICK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PICK1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PICK1
    Browse ESI BIO Cell Lines and PureStem Progenitors for PICK1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PICK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PICK1_HUMAN, Q9NRD5: Cytoplasm, perinuclear region. Membrane; Peripheral membrane protein (By similarity). Cell
    junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse,
    synaptosome (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Also membrane-associated, present at
    excitatory synapses (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    golgi apparatus4
    cytosol2
    mitochondrion2
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA11343649
    GO:0005739mitochondrion IEA--
    GO:0005794Golgi apparatus ISS--
    GO:0005886plasma membrane TAS--
    GO:0014069postsynaptic density IEA--

    PICK1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PICK1 About    
    See pathways by source

    SuperPathContained pathways About
    1Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    2Trafficking of AMPA receptors
    Trafficking of AMPA receptors1.00
    Trafficking of GluR2-containing AMPA receptors0.00
    Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity1.00
    3Synaptic transmission ion currents
    Synaptic transmission ion currents

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for PICK1
        Trafficking of GluR2-containing AMPA receptors



    PICK1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including PICK1: 
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PICK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PICK1 (Q9NRD51, 2, 3 ENSP000003494654) via UniProtKB, MINT, STRING, and/or I2D (see all 92)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COILP384321, 2, 3, ENSP000002403164EBI-79165,EBI-945751 MINT-2866636 MINT-2866655 MINT-2866617 I2D: score=3 STRING: ENSP00000240316
    SLC6A3Q019592, 3, ENSP000002703494MINT-73279 MINT-73284 MINT-73280 MINT-73281 I2D: score=5 STRING: ENSP00000270349
    SLC6A2P239752, 3, ENSP000003692374MINT-73297 MINT-73299 MINT-73295 I2D: score=2 STRING: ENSP00000369237
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2866712 MINT-2866731 I2D: score=3 STRING: ENSP00000344782
    PRKCGP051292, 3, ENSP000002634314MINT-2866769 MINT-2866750 I2D: score=3 STRING: ENSP00000263431
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002092positive regulation of receptor internalization ISS--
    GO:0006200ATP catabolic process ISS--
    GO:0006468protein phosphorylation ISS--
    GO:0006605protein targeting IEA--
    GO:0006890retrograde vesicle-mediated transport, Golgi to ER NAS10623590

    PICK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PICK1

    1 HMDB Compound for PICK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    8 Novoseek inferred chemical compound relationships for PICK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 62.4 18 11144358 (2), 18077702 (2), 11466413 (2), 11641419 (1) (see all 12)
    nmda 51.7 12 16406232 (2), 18367088 (2), 19644508 (2), 18077702 (2) (see all 6)
    kainate 35.4 6 12597860 (2), 18692513 (2), 12941441 (1)
    dopamine 23.6 8 17606663 (2), 18411704 (1), 17266593 (1), 18466293 (1) (see all 6)
    lipid 4.46 16 17914463 (3), 16510715 (2), 18032668 (2), 17215589 (2) (see all 5)
    calcium 0 2 18353440 (1), 15190111 (1)
    tyrosine 0 2 17266593 (1), 15240807 (1)
    serine 0 4 16314870 (3)

    1 PharmGKB related drug/compound annotation for PICK1 gene    About this table
    Drug/compound PharmGKB Annotation
    methamphetamineCA  



    PICK1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PICK1 gene (3 alternative transcripts): 
    NM_001039583.1  NM_001039584.1  NM_012407.3  

    Unigene Cluster for PICK1:

    Protein interacting with PRKCA 1
    Hs.180871  [show with all ESTs]
    Unigene Representative Sequence: NM_012407
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000445628 ENST00000404072(uc003auq.3 uc003aur.3 uc003aus.3)
    ENST00000424694 ENST00000484021 ENST00000437453 ENST00000476157 ENST00000468288
    ENST00000426258 ENST00000469819 ENST00000356976(uc003aut.3) ENST00000466374
    ENST00000435166 ENST00000432756 ENST00000472724 ENST00000494434
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PICK1 (see all 9):
    hsa-miR-1321 hsa-miR-491-3p hsa-miR-650 hsa-miR-3142 hsa-miR-214 hsa-miR-532-3p hsa-miR-761 hsa-miR-3612
    SwitchGear 3'UTR luciferase reporter plasmidPICK1 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat PICK1

    Additional mRNA sequence: 

    AB026491.1 AF231710.1 AK000875.1 AK222640.1 AK308792.1 AK310629.1 AL049654.1 AL137355.1 
    BC017561.2 CR456550.1 

    13 DOTS entries:

    DT.75101687  DT.100789982  DT.75182388  DT.97841396  DT.100789984  DT.120660305  DT.100771422  DT.100789977 
    DT.120660237  DT.120660238  DT.120660243  DT.120660244  DT.102827618 

    Selected AceView cDNA sequences (see all 137):

    BM800257 BC017561 CB113123 AU105100 BQ927610 AK000875 BI822139 CR456550 
    BX119076 AU099301 CB152372 AB026491 AL079512 BP350355 BQ439780 AL049654 
    AK092818 BM717306 NM_012407 BG681123 BP357119 CB151493 AI560680 CB141073 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PICK1 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                -     -           -                       -           -                                   -                                 
    SP2:                                      -           -                       -           -                                   -                                 
    SP3:                          -     -     -           -                       -           -                                   -                                 
    SP4:                                      -           -                       -     -     -                                                                     
    SP5:                                      -           -     -     -           -     -     -                                                                     


    ECgene alternative splicing isoforms for PICK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PICK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTGGGACC
    PICK1 Expression
    About this image

    PICK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PICK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.180871

    UniProtKB/Swiss-Prot: PICK1_HUMAN, Q9NRD5
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including PICK1: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PICK1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pick11 , 5 protein interacting with C kinase 11, 5 89.16(n)1
    95.66(a)1
      15 (37.70 cM)5
    186931  NM_001045558.11  NP_001039023.11 
     792291735 
    chicken
    (Gallus gallus)
    Aves PICK11 protein interacting with PRKCA 1 80.82(n)
    94.62(a)
      418030  XM_416267.4  XP_416267.2 
    lizard
    (Anolis carolinensis)
    Reptilia PICK16
    protein interacting with PRKCA 1
    85(a)
    1 ↔ 1
    GL343460.1(234421-255204)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.191622 Xenopus laevis transcribed sequence with moderate similarity more 77.91(n)    BI447955.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pick11 protein interacting with prkca 1 78.08(n)
    87.33(a)
      768194  NM_001077336.1  NP_001070804.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta PICK11 PICK1 60.84(n)
    60.93(a)
      34677  NM_135738.2  NP_609582.3 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y57G11C.221 CELE_Y57G11C.22 51.23(n)
    49.04(a)
      178409  NM_001047581.2  NP_001041046.1 


    ENSEMBL Gene Tree for PICK1 (if available)
    TreeFam Gene Tree for PICK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PICK1 (see all 462)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1813051971,2
    --38451262(+) AACAGG/TGGCAT 3 -- us2k10--------
    rs65190961,2
    C,F,A--38451389(+) TGTTTC/TTGAGA 3 -- us2k1 tfbs36Minor allele frequency- T:0.30NA WA EA 364
    rs718082421,2
    C--38451405(+) TCTGG-/CTCTGTC 3 -- us2k10--------
    rs1854289151,2
    --38451405(+) TCTGGC/GTCTGT 3 -- us2k10--------
    rs1906905551,2
    --38451434(+) ATGGCA/GCGATC 3 -- us2k10--------
    rs65190971,2
    C,F,A--38451465(+) CCACCC/TGGGTC 3 -- us2k15Minor allele frequency- T:0.28WA CSA NA EA 245
    rs1813764131,2
    C--38451475(+) CCAAGC/TGATTC 3 -- us2k10--------
    rs1872162831,2
    --38451476(+) CAAGCA/GATTCT 3 -- us2k10--------
    rs81428871,2
    C,F,A--38451553(+) TTTTTG/AGTAGA 3 -- us2k13Minor allele frequency- A:0.33NA WA CSA 6
    rs768479461,2
    C--38451751(+) CATTCA/TACACG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for PICK1 (38452318 - 38471708 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PICK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv471198CNV Loss18288195
    nsv915053CNV Loss21882294
    nsv915035CNV Loss21882294
    nsv834193CNV Loss17160897
    nsv834194CNV Loss17160897
    dgv4969n71CNV Loss21882294
    dgv4968n71CNV Loss21882294
    nsv915054CNV Loss21882294

    Human Gene Mutation Database (HGMD): PICK1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PICK1
    DNA2.0 Custom Variant and Variant Library Synthesis for PICK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605926    OMIM disorders: --

    20 diseases for PICK1:    
    About MalaCards
    gastroesophageal junction adenocarcinoma    globozoospermia    mutism    substance dependence
    central nervous system disease    nervous system disease    pick's disease    male infertility
    intrahepatic cholangiocarcinoma    spinocerebellar ataxia    cholangiocarcinoma    schizophrenia
    infertility    attention deficit hyperactivity disorder    ataxia    cerebritis
    adenocarcinoma    malaria    neuronitis    breast cancer


    PICK1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for PICK1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 26.4 17 17367885 (5), 15305146 (3), 17011050 (2), 16983646 (1) (see all 7)

    Genetic Association Database (GAD): PICK1
    Human Genome Epidemiology (HuGE) Navigator: PICK1 (7 documents)

    Export disorders for PICK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PICK1 gene, integrated from 10 sources (see all 117):
    (articles sorted by number of sources associating them with PICK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I.... Wright H. (Nature 1999)
    2. Interaction of the PDZ domain of human PICK1 with class I ADP- ribosylation factors. (PubMed id 10623590)1, 2, 9 Takeya R.... Sumimoto H. (Biochem. Biophys. Res. Commun. 2000)
    3. Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis. (PubMed id 17606663)1, 4, 9 Matsuzawa D....Iyo M. (Am J Psychiatry 2007)
    4. PICK1 is not a susceptibility gene for schizophrenia in a Japanese population: association study in a large case-control population. (PubMed id 17367885)1, 4, 9 Ishiguro H....Arinami T. (Neurosci. Res. 2007)
    5. Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. (PubMed id 11343649)1, 2, 9 Torres G.E.... Caron M.G. (Neuron 2001)
    6. The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy- 5-methylisoxazole-4-propionic acid receptor clustering. (PubMed id 11641419)1, 2, 9 Lin S.H.S.... Civelli O. (Mol. Pharmacol. 2001)
    7. Genetic association studies of methamphetamine use disorders: A systematic review and synthesis. (PubMed id 19219857)1, 4, 9 Bousman C.A....Tsuang M.T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    8. A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth. (PubMed id 15304526)1, 2, 9 Ashbourne-Excoffon K.J.D....Zabner J. (J. Cell Sci. 2004)
    9. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    10. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9463 HGNC: 9394 AceView: PRKCABP Ensembl:ENSG00000100151 euGenes: HUgn9463
    ECgene: PICK1 H-InvDB: PICK1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PICK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PICK1 gene:
    Search GeneIP for patents involving PICK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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