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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PICK1 Gene

protein-coding   GIFtS: 59
GCID: GC22P038452

Protein Interacting With PRKCA 1

(Previous names: protein kinase C, alpha binding protein, protein interacting...)
(Previous symbol: PRKCABP)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Interacting With PRKCA 11 2     Protein Interacting With PRKCA1
PRKCABP1 2 3 5     Protein Kinase C, Alpha Binding Protein1
Protein Interacting With C Kinase 12 3     PICK2
Protein Kinase C-Alpha-Binding Protein2 3     PRKCA-Binding Protein2

External Ids:    HGNC: 93941   Entrez Gene: 94632   Ensembl: ENSG000001001517   OMIM: 6059265   UniProtKB: Q9NRD53   

Export aliases for PICK1 gene to outside databases

Previous GC identifers: GC22P036783 GC22P021417


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PICK1 Gene:
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha
(PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a
variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine
plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these
membrane proteins and thus regulate their distribution and function. This protein has also been found to act as
an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three
transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PICK1 Gene: 
PICK1 (protein interacting with PRKCA 1) is a protein-coding gene. Diseases associated with PICK1 include gastroesophageal junction adenocarcinoma, and globozoospermia, and among its related super-pathways are Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell and Trafficking of GluR2-containing AMPA receptors. GO annotations related to this gene include protein domain specific binding and receptor binding.

UniProtKB/Swiss-Prot: PICK1_HUMAN, Q9NRD5
Function: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane
proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by
acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking
and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric
ASIC1/ASIC3 channel

Gene Wiki entry for PICK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PICK1 gene promoter:
         GR   Sp1   ATF-2   GR-beta   MyoD   LCR-F1   CRE-BP1   PPAR-gamma1   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPICK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PICK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PICK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

PICK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PICK1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P038452:  view genomic region     (about GC identifiers)

Start:
38,452,318 bp from pter      End:
38,471,708 bp from pter
Size:
19,391 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PICK1_HUMAN, Q9NRD5 (See protein sequence)
Recommended Name: PRKCA-binding protein  
Size: 415 amino acids; 46600 Da
Subunit: Monomer and homodimer. Interacts presynaptically with the monoamine transporters SLC6A2 and SLC6A3; with
the channel proteins ASIC1 and ASIC2; with the GTP-binding proteins ARF1 and ARF3. Interacts with PRKCA; with the
ephrin receptor tyrosine kinases EPHA7, EPHB1 and EPHB2; and with ERBB2. Interacts with BTG2; with the glutamate
receptors GRIA2, GRIA3, the isoform A of GRM4, GRM7 and GRM8; and with NAPA and NAPB. The interaction with NAPA
and NAPB disrupts the interaction with GRIA2, conducting to the internalization of GRIA2. Interacts with UNC5A
(By similarity). Interacts with CXADR. Interacts through its PDZ domain with the C-terminal tail of PRLHR.
Interacts (via AH domain) with NCS1/FREQ; in a calcium-dependent manner (By similarity)
Subcellular location: Cytoplasm, perinuclear region. Cell junction, synapse. Note=Also present at excitatory
synapses
1 PDB 3D structure from and Proteopedia for PICK1:
2GZV (3D)    
Secondary accessions: O95906

Explore the universe of human proteins at neXtProt for PICK1: NX_Q9NRD5

Explore proteomics data for PICK1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NRD5

  • PICK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PICK1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001034672.1  NP_001034673.1  NP_036539.1  

    ENSEMBL proteins: 
     ENSP00000416487   ENSP00000385205   ENSP00000398141   ENSP00000410793   ENSP00000413962  
     ENSP00000349465   ENSP00000397588   ENSP00000387861  
    Reactome Protein details: Q9NRD5
    Human Recombinant Protein Products for PICK1: 
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    Novus Biologicals PICK1 Proteins
    Novus Biologicals PICK1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PICK1 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA11343649
    GO:0005739mitochondrion IEA--
    GO:0005794Golgi apparatus ISS--
    GO:0005886plasma membrane TAS--
    GO:0030054cell junction IEA--

    PICK1 for ontologies           About GeneDecksing



    PICK1 Antibody Products: 
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    Assay Products for PICK1: 
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    Cloud-Clone Corp. ELISAs for PICK1 
    Cloud-Clone Corp. CLIAs for PICK1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR027267 AH/BAR-dom
     IPR001478 PDZ
     IPR010504 AH_dom

    Graphical View of Domain Structure for InterPro Entry Q9NRD5

    ProtoNet protein and cluster: Q9NRD5

    2 Blocks protein domains:
    IPB001478 PDZ/DHR/GLGF domain
    IPB010504 Arfaptin-like


    UniProtKB/Swiss-Prot: PICK1_HUMAN, Q9NRD5
    Similarity: Contains 1 AH domain
    Similarity: Contains 1 PDZ (DHR) domain


    PICK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PICK1_HUMAN, Q9NRD5
    Function: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane
    proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by
    acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking
    and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric
    ASIC1/ASIC3 channel

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005080protein kinase C binding ISS--
    GO:0005102receptor binding ISS--
    GO:0005515protein binding IPI11802773
    GO:0008022protein C-terminus binding IPI11343649
    GO:0016887ATPase activity ISS--
         
    PICK1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PICK1:
     G0/1 arrest  Increased G1 DNA content 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pick1):
     cellular  endocrine/exocrine gland  nervous system  reproductive system 

    PICK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pick1tm1Rlh for PICK1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PICK1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PICK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PICK1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PICK1 

    miRNA
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    hsa-miR-1321 hsa-miR-491-3p hsa-miR-650 hsa-miR-3142 hsa-miR-214 hsa-miR-532-3p hsa-miR-761 hsa-miR-3612
    SwitchGear 3'UTR luciferase reporter plasmidPICK1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PICK1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.67
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    2Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
    Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity0.53
    Trafficking of GluR2-containing AMPA receptors0.53
    Trafficking of AMPA receptors0.53
    3Synaptic transmission: ion currents
    Synaptic transmission: ion currents

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PICK1
        Synaptic transmission- ion currents


    5/6        Reactome Pathways for PICK1 (see all 6)
        Trafficking of AMPA receptors
    Transmission across Chemical Synapses
    Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
    Neuronal System
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell



    PICK1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PICK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/79 Interacting proteins for PICK1 (Q9NRD51, 2, 3 ENSP000003494654) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COILP384321, 2, 3, ENSP000002403164EBI-79165,EBI-945751 MINT-2866636 MINT-2866655 MINT-2866617 I2D: score=3 STRING: ENSP00000240316
    SLC6A3Q019592, 3, ENSP000002703494MINT-73279 MINT-73284 MINT-73280 MINT-73281 I2D: score=5 STRING: ENSP00000270349
    SLC6A2P239752, 3, ENSP000003692374MINT-73297 MINT-73299 MINT-73295 I2D: score=2 STRING: ENSP00000369237
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2866712 MINT-2866731 I2D: score=3 STRING: ENSP00000344782
    PRKCGP051292, 3, ENSP000002634314MINT-2866769 MINT-2866750 I2D: score=3 STRING: ENSP00000263431
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process ISS--
    GO:0006468protein phosphorylation ISS--
    GO:0006605protein targeting IEA--
    GO:0006890retrograde vesicle-mediated transport, Golgi to ER NAS10623590
    GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway IDA10623590

    PICK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PICK1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PICK1

    1 HMDB Compound for PICK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    8 Novoseek inferred chemical compound relationships for PICK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 62.4 18 11144358 (2), 18077702 (2), 11466413 (2), 11641419 (1) (see all 12)
    nmda 51.7 12 16406232 (2), 18367088 (2), 19644508 (2), 18077702 (2) (see all 6)
    kainate 35.4 6 12597860 (2), 18692513 (2), 12941441 (1)
    dopamine 23.6 8 17606663 (2), 18411704 (1), 17266593 (1), 18466293 (1) (see all 6)
    lipid 4.46 16 17914463 (3), 16510715 (2), 18032668 (2), 17215589 (2) (see all 5)
    calcium 0 2 18353440 (1), 15190111 (1)
    tyrosine 0 2 17266593 (1), 15240807 (1)
    serine 0 4 16314870 (3)

    1 PharmGKB related drug/compound annotation for PICK1 gene    About this table
    Drug/compound PharmGKB Annotation
    methamphetamineCA  

    Search CenterWatch for drugs/clinical trials and news about PICK1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PICK1 gene (3 alternative transcripts): 
    NM_001039583.1  NM_001039584.1  NM_012407.3  

    Unigene Cluster for PICK1:

    Protein interacting with PRKCA 1
    Hs.180871  [show with all ESTs]
    Unigene Representative Sequence: NM_012407
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000445628 ENST00000404072(uc003auq.3 uc003aur.3 uc003aus.3)
    ENST00000424694 ENST00000484021 ENST00000437453 ENST00000476157 ENST00000468288
    ENST00000426258 ENST00000469819 ENST00000356976(uc003aut.3) ENST00000466374
    ENST00000435166 ENST00000432756 ENST00000472724 ENST00000494434

    miRNA
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    hsa-miR-1321 hsa-miR-491-3p hsa-miR-650 hsa-miR-3142 hsa-miR-214 hsa-miR-532-3p hsa-miR-761 hsa-miR-3612
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    Additional mRNA sequence: 

    AB026491.1 AF231710.1 AK000875.1 AK222640.1 AK308792.1 AK310629.1 AL049654.1 AL137355.1 
    BC017561.2 CR456550.1 

    13 DOTS entries:

    DT.75101687  DT.100789982  DT.75182388  DT.97841396  DT.100789984  DT.120660305  DT.100771422  DT.100789977 
    DT.120660237  DT.120660238  DT.120660243  DT.120660244  DT.102827618 

    24/137 AceView cDNA sequences (see all 137):

    AL049654 CR613255 BP350355 BQ962710 CB151493 BQ439780 NM_012407 BQ018915 
    BQ440270 AK092818 AK000875 CB141073 AU099301 AL137355 BG681123 BM800257 
    BE408986 BX119076 AL079512 BC017561 AI560680 BQ927610 AB026491 BI822139 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for PICK1 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                -     -           -                       -           -                                   -                                 
    SP2:                                      -           -                       -           -                                   -                                 
    SP3:                          -     -     -           -                       -           -                                   -                                 
    SP4:                                      -           -                       -     -     -                                                                     
    SP5:                                      -           -     -     -           -     -     -                                                                     


    ECgene alternative splicing isoforms for PICK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PICK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTGGGACC
    PICK1 Expression
    About this image


    See PICK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PICK1

    SOURCE GeneReport for Unigene cluster: Hs.180871

    UniProtKB/Swiss-Prot: PICK1_HUMAN, Q9NRD5
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including PICK1: 
              Synaptic Plasticity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PICK1 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pick11 , 5 protein interacting with C kinase 11, 5 89.8(n)1
    96.63(a)1
      15 (37.70 cM)5
    186931  NM_001045558.11  NP_001039023.11 
     792291735 
    chicken
    (Gallus gallus)
    Aves PICK11 protein interacting with PRKCA 1 80.26(n)
    93.25(a)
      418030  XM_416267.3  XP_416267.2 
    lizard
    (Anolis carolinensis)
    Reptilia PICK16
    Uncharacterized protein
    85(a)
    1 ↔ 1
    GL343460.1(234421-255204)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.191622 Xenopus laevis transcribed sequence with moderate similarity more 77.91(n)    BI447955.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1532571 zgc:153257 75.66(n)
    82.43(a)
      768194  NM_001077336.1  NP_001070804.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta PICK11 CG6167-PA 60.69(n)
    60.16(a)
      34677  NM_135738.2  NP_609582.3 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y57G11C.221 Protein Y57G11C.22 50.74(n)
    48.04(a)
      178409  NM_001047581.1  NP_001041046.1 


    ENSEMBL Gene Tree for PICK1 (if available)
    TreeFam Gene Tree for PICK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/462 SNPs in PICK1 are shown (see all 462)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1813051971,2
    --38451262(+) AACAGG/TGGCAT 3 -- us2k10--------
    rs65190961,2
    C,F,A--38451389(+) TGTTTC/TTGAGA 3 -- us2k1 tfbs36Minor allele frequency- T:0.30NA WA EA 364
    rs718082421,2
    C--38451405(+) TCTGG-/CTCTGTC 3 -- us2k10--------
    rs1854289151,2
    --38451405(+) TCTGGC/GTCTGT 3 -- us2k10--------
    rs1906905551,2
    --38451434(+) ATGGCA/GCGATC 3 -- us2k10--------
    rs65190971,2
    C,F,A--38451465(+) CCACCC/TGGGTC 3 -- us2k15Minor allele frequency- T:0.28WA CSA NA EA 245
    rs1813764131,2
    C--38451475(+) CCAAGC/TGATTC 3 -- us2k10--------
    rs1872162831,2
    --38451476(+) CAAGCA/GATTCT 3 -- us2k10--------
    rs81428871,2
    C,F,A--38451553(+) TTTTTG/AGTAGA 3 -- us2k13Minor allele frequency- A:0.33NA WA CSA 6
    rs768479461,2
    C--38451751(+) CATTCA/TACACG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for PICK1 (38452318 - 38471708 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PICK1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv471198CNV Loss18288195
    nsv915053CNV Loss21882294
    nsv915035CNV Loss21882294
    nsv834193CNV Loss17160897
    nsv834194CNV Loss17160897
    dgv4969n71CNV Loss21882294
    dgv4968n71CNV Loss21882294
    nsv915054CNV Loss21882294


    Human Gene Mutation Database (HGMD): PICK1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605926    OMIM disorders: --

    16 diseases for PICK1:    About MalaCards
    gastroesophageal junction adenocarcinoma    globozoospermia    mutism    substance dependence
    pick's disease    male infertility    schizophrenia    infertility
    intrahepatic cholangiocarcinoma    spinocerebellar ataxia    cholangiocarcinoma    ataxia
    cerebritis    adenocarcinoma    neuronitis    breast cancer


    PICK1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for PICK1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 26.4 17 17367885 (5), 15305146 (3), 17011050 (2), 16983646 (1) (see all 7)

    Genetic Association Database (GAD): PICK1
    Human Genome Epidemiology (HuGE) Navigator: PICK1 (7 documents)

    Export disorders for PICK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PICK1 gene, integrated from 9 sources (see all 117):
    (articles sorted by number of sources associating them with PICK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I....O'Brien K.P. (1999)
    2. Interaction of the PDZ domain of human PICK1 with class I ADP- ribosylation factors. (PubMed id 10623590)1, 2, 9 Takeya R.... Sumimoto H. (2000)
    3. Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis. (PubMed id 17606663)1, 4, 9 Matsuzawa D....Iyo M. (2007)
    4. PICK1 is not a susceptibility gene for schizophrenia in a Japanese population: association study in a large case-control population. (PubMed id 17367885)1, 4, 9 Ishiguro H....Arinami T. (2007)
    5. Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. (PubMed id 11343649)1, 2, 9 Torres G.E.... Caron M.G. (2001)
    6. The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy- 5-methylisoxazole-4-propionic acid receptor clustering. (PubMed id 11641419)1, 2, 9 Lin S.H.S.... Civelli O. (2001)
    7. Genetic association studies of methamphetamine use disorders: A systematic review and synthesis. (PubMed id 19219857)1, 4, 9 Bousman C.A....Tsuang M.T. (2009)
    8. A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth. (PubMed id 15304526)1, 2, 9 Ashbourne-Excoffon K.J.D....Zabner J. (2004)
    9. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    10. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9463 HGNC: 9394 AceView: PRKCABP Ensembl:ENSG00000100151 euGenes: HUgn9463
    ECgene: PICK1 H-InvDB: PICK1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PICK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PICK1 gene:
    Search GeneIP for patents involving PICK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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