Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PICALM Gene

protein-coding   GIFtS: 63
GCID: GC11M085668

Phosphatidylinositol Binding Clathrin Assembly Protein

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phosphatidylinositol Binding Clathrin Assembly Protein1 2
CALM2 3 5
Clathrin Assembly Lymphoid Myeloid Leukemia Protein2 3
CLTH2 5
LAP2 5
Phosphatidylinositol-Binding Clathrin Assembly Protein2

External Ids:    HGNC: 155141   Entrez Gene: 83012   Ensembl: ENSG000000739217   OMIM: 6030255   UniProtKB: Q134923   

Export aliases for PICALM gene to outside databases

Previous GC identifers: GC11M087996 GC11M087208 GC11M085892 GC11M085396 GC11M085346 GC11M081965


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PICALM Gene:
This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell
membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to
determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The
protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal
translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute
lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are
associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, May 2011)

GeneCards Summary for PICALM Gene: 
PICALM (phosphatidylinositol binding clathrin assembly protein) is a protein-coding gene. Diseases associated with PICALM include myeloid leukemia, and leukemia, and among its related super-pathways are Golgi Associated Vesicle Biogenesis and Clathrin-dependent protein traffic. GO annotations related to this gene include 1-phosphatidylinositol binding and clathrin heavy chain binding. An important paralog of this gene is SNAP91.

UniProtKB/Swiss-Prot: PICAL_HUMAN, Q13492
Function: Assembly protein recruiting clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of
coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be
recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated
endocytosis at the neuromuscular junction

Gene Wiki entry for PICALM Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PICALM gene promoter:
         HOXA9   HOXA9B   AML1a   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   CUTL1   POU3F2   Meis-1b   PPAR-alpha   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPICALM promoter sequence
   Search SABiosciences Chromatin IP Primers for PICALM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PICALM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14   Ensembl cytogenetic band:  11q14.2   HGNC cytogenetic band: 11q14

PICALM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PICALM gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M085668:  view genomic region     (about GC identifiers)

Start:
85,668,214 bp from pter      End:
85,780,924 bp from pter
Size:
112,711 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PICAL_HUMAN, Q13492 (See protein sequence)
Recommended Name: Phosphatidylinositol-binding clathrin assembly protein  
Size: 652 amino acids; 70755 Da
Subunit: Binds clathrin; involves primarily the C-terminal sequences, but the full-length protein is required for
full binding capacity. Binds phosphatidylinositol 4,5- bisphosphate. Interacts with FAM64A; this interaction may
change the subcellular location into the nucleus
Subcellular location: Membrane, clathrin-coated pit. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated
vesicle. Nucleus. Note=Colocalized with clathrin in the Golgi area. Interaction with FAM64A may target PICALM to
the nucleus in some cells
Sequence caution: Sequence=BAE06099.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B4DTM3 E9PN05 F8VPG7 O60700 Q4LE54 Q6GMQ6 Q86XZ9
Alternative splicing: 5 isoforms:  Q13492-1   Q13492-2   Q13492-3   Q13492-4   Q13492-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PICALM: NX_Q13492

Explore proteomics data for PICALM at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13492

  • PICALM Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PICALM Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001008660.1  NP_001193875.1  NP_001193876.1  NP_009097.2  

    ENSEMBL proteins: 
     ENSP00000436958   ENSP00000433846   ENSP00000436852   ENSP00000377015   ENSP00000435807  
     ENSP00000434884   ENSP00000435311   ENSP00000348718   ENSP00000432509   ENSP00000432976  
     ENSP00000435737   ENSP00000435499   ENSP00000433166   ENSP00000433303   ENSP00000431728  
     ENSP00000436508   ENSP00000431545  
    Reactome Protein details: Q13492
    Human Recombinant Protein Products for PICALM: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PICALM
    OriGene Protein Over-expression Lysate for PICALM
    OriGene MassSpec for PICALM 
    OriGene Custom Protein Services for PICALM
    GenScript Custom Purified and Recombinant Proteins Services for PICALM
    Novus Biologicals PICALM Proteins
    Novus Biologicals PICALM Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PICALM 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA16491119
    GO:0005794Golgi apparatus IEA--
    GO:0005905coated pit ISS--
    GO:0030118clathrin coat ----

    PICALM for ontologies           About GeneDecksing



    PICALM Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for PICALM
    OriGene Custom Antibody Services for PICALM
    GenScript Custom Superior Antibodies Services for PICALM
    Novus Biologicals PICALM Antibodies
    Abcam antibodies for PICALM
    Cloud-Clone Corp. Antibodies for PICALM 
    ThermoFisher Antibodies for PICALM
    LSBio Antibodies in human, mouse, rat for PICALM 

    Assay Products for PICALM: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PICALM
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PICALM
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PICALM 
    Cloud-Clone Corp. CLIAs for PICALM


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR011417 ANTH_dom
     IPR014712 Clathrin_Pinositid-bd_GAT-like
     IPR008942 ENTH_VHS
     IPR013809 Epsin-like_N

    Graphical View of Domain Structure for InterPro Entry Q13492

    ProtoNet protein and cluster: Q13492

    2 Blocks protein domains:
    IPB001026 Epsin N-terminal homology
    IPB013809 Epsin-like


    UniProtKB/Swiss-Prot: PICAL_HUMAN, Q13492
    Similarity: Belongs to the PICALM/SNAP91 family
    Similarity: Contains 1 ENTH (epsin N-terminal homology) domain


    PICALM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PICAL_HUMAN, Q13492
    Function: Assembly protein recruiting clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of
    coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be
    recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated
    endocytosis at the neuromuscular junction

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16491119
    GO:0005543phospholipid binding ----
    GO:00055451-phosphatidylinositol binding ISS--
    GO:0030276clathrin binding ISS--
    GO:0032050clathrin heavy chain binding IDA10436022
         
    PICALM for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Picalm):
     cellular  embryogenesis  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging 

    PICALM for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Picalmtm1Towa for PICALM

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PICALM 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PICALM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PICALM 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PICALM 

    miRNA
    Products:
        
    miRTarBase miRNAs that target PICALM:
    hsa-mir-155 (MIRT001525), hsa-mir-1 (MIRT001350)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PICALM
    8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate PICALM (see all 64):
    hsa-miR-3678-3p hsa-miR-3685 hsa-miR-579 hsa-miR-520f hsa-miR-3616-5p hsa-let-7a-2* hsa-miR-30d hsa-miR-3171
    SwitchGear 3'UTR luciferase reporter plasmidPICALM 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PICALM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PICALM

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PICALM
    Sirion Biotech Customized adenovirus for overexpression of PICALM

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PICALM (see all 13)
    OriGene ORF clones in mouse, rat for PICALM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PICALM (NM_007166)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PICALM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PICALM
    Sirion Biotech Customized lentivirus for stable overexpression of PICALM 
                         Customized lentivirus expression plasmids for stable overexpression of PICALM 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PICALM
    Search LifeMap BioReagents cell lines for PICALM
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PICALM


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PICALM About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    trans-Golgi Network Vesicle Budding0.89
    Golgi Associated Vesicle Biogenesis0.89
    2Clathrin-dependent protein traffic
    Transport Clathrin-coated vesicle cycle0.66
    wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)0.35
    3Membrane Trafficking
    Membrane Trafficking0.32
    4Notch Signaling Pathways
    Notch Signaling Pathways

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for PICALM
        Notch Signaling Pathways


    2 GeneGo (Thomson Reuters) Pathways for PICALM
        wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)
    Transport Clathrin-coated vesicle cycle

    4        Reactome Pathways for PICALM
        Membrane Trafficking
    Clathrin derived vesicle budding
    Golgi Associated Vesicle Biogenesis
    trans-Golgi Network Vesicle Budding



    PICALM for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PICALM

    5/798 Interacting proteins for PICALM (Q134922, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 798)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOC2Q96KP12, 3MINT-7945693 MINT-7947479 I2D: score=4 
    MDN1Q9NU222, 3MINT-7945693 MINT-7947479 I2D: score=2 
    DIAPH1O606102, 3MINT-7945693 MINT-7947479 I2D: score=1 
    HDAC1Q135472, 3MINT-7945693 MINT-7947479 I2D: score=1 
    HIP1RO751462, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly TAS8643484
    GO:0006898receptor-mediated endocytosis ISS--
    GO:0007409axonogenesis IEA--
    GO:0016192vesicle-mediated transport TAS8643484
    GO:0016197endosomal transport IMP16262731

    PICALM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PICALM for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PICALM (PICAL)

    3 Novoseek inferred chemical compound relationships for PICALM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    af 10 97.4 22 9737689 (4), 10554802 (3), 12461747 (2), 9365832 (2) (see all 12)
    leucine 39.6 1 11756182 (1)
    iron 0 2 12832620 (2)

    Search CenterWatch for drugs/clinical trials and news about PICALM / PICAL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PICALM gene (4 alternative transcripts): 
    NM_001008660.2  NM_001206946.1  NM_001206947.1  NM_007166.3  

    Unigene Cluster for PICALM:

    Phosphatidylinositol binding clathrin assembly protein
    Hs.163893  [show with all ESTs]
    Unigene Representative Sequence: NM_007166
    18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000532317(uc001pbk.3 uc010rtk.2 uc010rtl.2) ENST00000526033(uc001pbl.3 uc001pbm.3 uc001pbn.3)
    ENST00000530692 ENST00000526548 ENST00000393346(uc001pbo.1) ENST00000529760
    ENST00000528398 ENST00000532603 ENST00000356360 ENST00000529016 ENST00000526961
    ENST00000526907 ENST00000530542 ENST00000534375 ENST00000534412 ENST00000533350
    ENST00000531771 ENST00000531558

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PICALM
    8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate PICALM (see all 64):
    hsa-miR-3678-3p hsa-miR-3685 hsa-miR-579 hsa-miR-520f hsa-miR-3616-5p hsa-let-7a-2* hsa-miR-30d hsa-miR-3171
    SwitchGear 3'UTR luciferase reporter plasmidPICALM 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PICALM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PICALM
    Clone
    Products:
         
    OriGene clones in human, mouse for PICALM (see all 13)
    OriGene ORF clones in mouse, rat for PICALM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PICALM (NM_007166)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PICALM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PICALM
    Sirion Biotech Customized lentivirus for stable overexpression of PICALM 
                         Customized lentivirus expression plasmids for stable overexpression of PICALM 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PICALM
    OriGene qSTAR qPCR primer pairs in human, mouse for PICALM
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PICALM
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PICALM
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PICALM

    Additional mRNA sequence: 

    AB210017.1 AB451308.1 AF060928.1 AF060939.1 AF060940.1 AK128786.1 AK291414.1 AK297062.1 
    AK300275.1 BC048259.1 BC064357.1 BC073961.1 BX640931.1 CR749664.1 EF051633.1 U45976.1 

    24/26 DOTS entries (see all 26):

    DT.87017228  DT.92411941  DT.102836498  DT.100788626  DT.100763707  DT.99958085  DT.95156877  DT.120717995 
    DT.100788623  DT.434615  DT.100788628  DT.100788621  DT.40111948  DT.120718082  DT.75130577  DT.120718026 
    DT.120718028  DT.120718083  DT.120718094  DT.40107327  DT.87017226  DT.91708568  DT.95156868  DT.120717971 

    24/412 AceView cDNA sequences (see all 412):

    BC064357 BP373238 AA159793 AI417263 BF437595 AI289638 AW054705 BG105833 
    BE645669 AA369399 BM981894 AA442040 AI631684 BQ437997 BM716709 AI432208 
    AI962766 AW264573 BE018446 AL135735 N72804 BQ719585 AI573163 BM710709 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for PICALM (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
    SP1:                                                        -                                                                             -     -               
    SP2:                                                        -                                   -                                         -     -               
    SP3:                                                                                            -     -                                   -     -               
    SP4:                                                                                                              -                       -     -               
    SP5:              -                                                                                                                                             

    ExUns: 21 ^ 22a · 22b · 22c · 22d · 22e · 22f
    SP1:  -                                       
    SP2:  -                                       
    SP3:  -                                       
    SP4:  -                                       
    SP5:                                          


    ECgene alternative splicing isoforms for PICALM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PICALM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTTAAGCA
    PICALM Expression
    About this image


    See PICALM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PICALM

    SOURCE GeneReport for Unigene cluster: Hs.163893

    UniProtKB/Swiss-Prot: PICAL_HUMAN, Q13492
    Tissue specificity: Expressed in all tissues examined

        SABiosciences Custom PCR Arrays for PICALM
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PICALM
    OriGene qSTAR qPCR primer pairs in human, mouse for PICALM
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PICALM
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PICALM
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PICALM
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PICALM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PICALM gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Picalm1 , 5 phosphatidylinositol binding clathrin assembly protein1, 5 94.38(n)1
    97.7(a)1
      7 (50.47 cM)5
    2334891  NM_146194.41  NP_666306.21 
     901302325 
    chicken
    (Gallus gallus)
    Aves PICALM1 phosphatidylinositol binding clathrin assembly protein 87.05(n)
    94.31(a)
      425991  XM_423671.3  XP_423671.3 
    lizard
    (Anolis carolinensis)
    Reptilia PICALM6
    phosphatidylinositol binding clathrin assembly pro...
    85(a)
    1 ↔ 1
    3(200435288-200515771)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.75532 Transcribed sequence with strong similarity to protein more 84.08(n)    BX719064.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc556152 similar to phosphatidylinositol binding clathrin assembly more 76.14(n)   393901  BC045405.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta lap1 , 3 synaptic vesicle coating3
    like-AP1801
    52(a)3
    51.38(n)1
    48.08(a)1
      408631  NM_001144547.21  NP_001138019.21 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-113 Expression: neurons 58(a)   I(3799173-3805706)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YAP18011 Yap1801p 41.05(n)
    26.54(a)
      856566   NP_012031.1 


    ENSEMBL Gene Tree for PICALM (if available)
    TreeFam Gene Tree for PICALM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PICALM gene
    SNAP912  
    3 SIMAP similar genes for PICALM using alignment to 14 protein entries:     PICAL_HUMAN (see all proteins):
    CALM/AF10 fusion    MLL/CALM fusion    SNAP91

    PICALM for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2672 SNPs in PICALM are shown (see all 2672)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs355277611,2
    C--81968418(+) CAAAGATCT/-  
            
    ATTAC
    4 -- int11Minor allele frequency- -:0.00CSA 2
    rs679110821,2
    C--81968419(+) AAAGA-/AT    
       CT
    /TC
    TTACT
    4 -- int10--------
    rs714689731,2
    C--81968420(+) AAGATCTAT/-  
            
    TACTG
    4 -- int11Minor allele frequency- -:0.50NA 2
    rs2018230701,2
    C--81968421(+) AAGATC/TACTGA 4 -- int10--------
    rs348306811,2
    C--81972900(+) CTCTG-/TTATGT 4 -- int12Minor allele frequency- T:0.00NA CSA 4
    rs569766691,2
    C--81974034(+) TGTTTG/TTTTTT 4 -- int11Minor allele frequency- T:0.00WA 2
    rs1429849731,2
    C--81975591(+) GATTT-/CTACCTTT 4 -- int10--------
    rs105512521,2
    C--81975592(+) ATTTCTAC/-CTTTT 4 -- int11Minor allele frequency- -:0.50NA 2
    rs105623821,2
    F--81975593(+) GATTT-/CT    
       A
    /TAC
    CCTTT
    12 -- int1 cds15EU EA NA MN 430
    rs803426121,2
    C--81976154(+) CTGCA-/AACAACAA 4 -- cds10--------

    HapMap Linkage Disequilibrium report for PICALM (85668214 - 85780924 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PICALM:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv164n27CNV Loss19166990
    nsv898054CNV Loss21882294
    nsv469975CNV Gain18288195


    Human Gene Mutation Database (HGMD): PICALM
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PICALM
    DNA2.0 Custom Variant and Variant Library Synthesis for PICALM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603025   
    OMIM disorders: 601626  
    UniProtKB/Swiss-Prot: PICAL_HUMAN, Q13492
  • Note=A chromosomal aberration involving PICALM is found in diffuse histiocytic lymphomas. Translocation
    t(10;11)(p13;q14) with MLLT10

  • 18 diseases for PICALM:    About MalaCards
    myeloid leukemia    leukemia    lymphoblastic leukemia    acute lymphoblastic leukemia
    thyroid lymphoma    auditory neuropathy    acute myeloid leukemia    lymphoblastic lymphoma
    polycythemia    polycythemia vera    alzheimer's disease    autoimmune thyroiditis
    acute leukemia    herpes simplex    neuropathy    down syndrome
    thyroiditis    neuronitis

    3 diseases from the University of Copenhagen DISEASES database for PICALM:
    Thyroid lymphoma     Alzheimer's disease     Autoimmune thyroiditis

    PICALM for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    8 Novoseek inferred disease relationships for PICALM gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia 76.2 9 12461747 (1), 9365832 (1), 11161218 (1), 14985334 (1) (see all 9)
    t-all 74.7 2 16107895 (1), 16921363 (1)
    lymphoma large cell diffuse 59.1 1 9737689 (1)
    leukemogenesis 57.1 1 12461747 (1)
    leukemia 48.5 7 12461747 (1), 9737689 (1), 12832620 (1), 16107895 (1) (see all 6)
    hematologic malignancies 41.2 1 9737689 (1)
    lymphoblastic leukemia acute 36.7 1 10637482 (1)
    lymphoma 23.2 1 12832620 (1)

    Genetic Association Database (GAD): PICALM
    Human Genome Epidemiology (HuGE) Navigator: PICALM (23 documents)

    Export disorders for PICALM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PICALM gene, integrated from 9 sources (see all 106):
    (articles sorted by number of sources associating them with PICALM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family. (PubMed id 8643484)1, 2, 3, 9 Dreyling M.H....Bohlander S.K. (1996)
    2. Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10- CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14- q21) suggests a potential role for truncated AF10 polypeptides. (PubMed id 9737689)1, 2, 9 Silliman C.C.... Hunger S.P. (1998)
    3. The membrane-spanning 4-domains, subfamily A (MS4A) g ene cluster contains a common variant associated with Alzheimer's disease. (PubMed id 21627779)1, 4 AntA_nez C....Ruiz A. (2011)
    4. The role of clusterin, complement receptor 1, and pho sphatidylinositol binding clathrin assembly protein in Alzheimer disease risk a nd cerebrospinal fluid biomarker levels. (PubMed id 21300948)1, 4 Schjeide B.M....Bertram L. (2011)
    5. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA 1 are associated with late-onset Alzheimer's disease. (PubMed id 21460841)1, 4 Naj A.C....Schellenberg G.D. (2011)
    6. Association of CR1, CLU and PICALM with Alzheimer's d isease in a cohort of clinically characterized and neuropathologically verified individuals. (PubMed id 20534741)1, 4 Corneveaux J.J....Huentelman M.J. (2010)
    7. Replication of CLU, CR1, and PICALM associations with alzheimer disease. (PubMed id 20554627)1, 4 Carrasquillo M.M....Younkin S.G. (2010)
    8. Genome-wide analysis of genetic loci associated with Alzheimer disease. (PubMed id 20460622)1, 4 Seshadri S....Breteler M.M. (2010)
    9. Genetic variation and neuroimaging measures in Alzhei mer disease. (PubMed id 20558387)1, 4 Biffi A....Rosand J. (2010)
    10. Meta-analysis confirms CR1, CLU, and PICALM as alzhei mer disease risk loci and reveals interactions with APOE genotypes. (PubMed id 20697030)1, 4 Jun G....Schellenberg G.D. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8301 HGNC: 15514 AceView: PICALM Ensembl:ENSG00000073921 euGenes: HUgn8301
    ECgene: PICALM H-InvDB: PICALM

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PICALM Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PICALM Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PICALM gene:
    Search GeneIP for patents involving PICALM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PICALM   OriGene RNAi products in human, mouse, rat for PICALM  
     OriGene qPCR primer pairs and template standards for PICALM   OriGene Protein Over-expression Lysate for PICALM  
     OriGene MassSpec something-or-other for PICALM   OriGene clones in human, mouse for PICALM  
     OriGene qSTAR qPCR primer pairs in human, mouse for PICALM   OriGene Purified Protein for PICALM  
     OriGene ORF clones in mouse, rat for PICALM   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PICALM   OriGene Custom Protein Services for PICALM  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PICALM
     QIAGEN SeqTarget long-range PCR primers for resequencing PICALM
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PICALM
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PICALM
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PICALM
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PICALM
     GenScript Custom Purified and Recombinant Proteins Services for PICALM GenScript cDNA clones with any tag delivered in your preferred vector for PICALM
     GenScript Custom Assay Services for PICALM GenScript Custom Superior Antibodies Services for PICALM
     GenScript Custom overexpressing Cell Line Services for PICALM CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PICALM promoter
     Search Chromatin IP Primers for PICALM
     RT2 qPCR Primer Assay in human, mouse, rat PICALM
     Search GNC Networks for PICALM
     SABiosciences Custom PCR Arrays for PICALM
     Search Tocris compounds for PICALM (PICAL)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PICALM antibodies
     PICALM proteins
     PICALM lysates
     Antibodies for PICALM
     See all of Abcam's Antibodies, Kits and Proteins for PICALM
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for PICALM
     Antibodies for PICALM
     ELISAs for PICALM
     CLIAs for PICALM
     Search LifeMap BioReagents cell lines for PICALM
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PICALM
     SwitchGear 3'UTR luciferase reporter plasmids for PICALM
     SwitchGear Promoter luciferase reporter plasmids for PICALM
     ThermoFisher Antibodies for PICALM
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PICALM
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PICALM
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PICALM
    Customized:
     lentivirus for stable overexpression of PICALM
     lentivirus expression plasmids for stable overexpression of PICALM
     adenovirus for overexpression of PICALM
     LSBio Antibodies in human, mouse, rat for PICALM
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PICALM gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4