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Aliases for PIBF1 Gene

Aliases for PIBF1 Gene

  • Progesterone Immunomodulatory Binding Factor 1 2 3 5
  • Centrosomal Protein Of 90 KDa 3 4
  • C13orf24 3 4
  • CEP90 3 4
  • PIBF 3 4
  • Progesterone-Induced Blocking Factor 1 2
  • Progesterone-Induced-Blocking Factor 1 3
  • Chromosome 13 Open Reading Frame 24 2

External Ids for PIBF1 Gene

Previous HGNC Symbols for PIBF1 Gene

  • C13orf24

Previous GeneCards Identifiers for PIBF1 Gene

  • GC13P071323
  • GC13P067351
  • GC13P072292
  • GC13P071154
  • GC13P072255
  • GC13P073356
  • GC13P054053

Summaries for PIBF1 Gene

GeneCards Summary for PIBF1 Gene

PIBF1 (Progesterone Immunomodulatory Binding Factor 1) is a Protein Coding gene. Diseases associated with PIBF1 include Breast Lymphoma and Pregnancy Loss, Recurrent 1.

UniProtKB/Swiss-Prot for PIBF1 Gene

  • Isoform 1: Pericentriolar protein required to maintain mitotic spindle pole integrity (PubMed:21224392). Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation (PubMed:23110211). Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 (PubMed:26297806).

  • Isoform 4: The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual naturakl killer cells (NK) activity exerts an anti-abortive effect (PubMed:14634107, PubMed:3863495, PubMed:12516630). Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein (PubMed:16393965, PubMed:25218441).

Gene Wiki entry for PIBF1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIBF1 Gene

Genomics for PIBF1 Gene

Regulatory Elements for PIBF1 Gene

Enhancers for PIBF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F072863 0.7 Ensembl ENCODE 13.5 +82.8 82774 2.1 ZBED1 JUNB CREM PIBF1 GC13M072882 RNU6-79P DIS3
GH13F072650 1.6 VISTA 5.5 -131.0 -131044 1.5 ELF3 CTCF PKNOX1 SMARCA4 SCRT2 RAD21 SPI1 ENSG00000199282 PIBF1 RPL21P110
GH13F072780 1.1 ENCODE 7.1 +0.1 74 3.3 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF207 SP3 PIBF1 DIS3
GH13F072726 1.1 ENCODE 6.3 -54.1 -54116 3.2 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 BORA MZT1 PIBF1
GH13F072821 0.6 ENCODE 11 +38.8 38769 0.1 OSR2 ZNF664 PRDM10 ATF2 SP7 TRIM28 PIBF1 DIS3 RNU6-79P GC13M072882
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PIBF1 on UCSC Golden Path with GeneCards custom track

Promoters for PIBF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000517440 41 3800 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF207

Genomic Location for PIBF1 Gene

Chromosome:
13
Start:
72,782,059 bp from pter
End:
73,016,461 bp from pter
Size:
234,403 bases
Orientation:
Plus strand

Genomic View for PIBF1 Gene

Genes around PIBF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIBF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIBF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIBF1 Gene

Proteins for PIBF1 Gene

  • Protein details for PIBF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXW3-PIBF1_HUMAN
    Recommended name:
    Progesterone-induced-blocking factor 1
    Protein Accession:
    Q8WXW3
    Secondary Accessions:
    • O95664
    • Q6U9V2
    • Q6UG50
    • Q86V07
    • Q96SF4

    Protein attributes for PIBF1 Gene

    Size:
    757 amino acids
    Molecular mass:
    89805 Da
    Quaternary structure:
    • Isoform 1 interacts with PCM1, BBS4 and CEP63 (PubMed:21224392, PubMed:23110211, PubMed:26297806). Interacts with IL4R (PubMed:25218441).
    Miscellaneous:
    • During normal pregnancy, the production is continuously increasing until the 37th gestational week and is followed by a sharp decrease after the 41st week of gestation. In pathological pregnancies, urinary levels fail to increase. Candidate for the diagnosis of threatened premature pregnancy termination.

    Alternative splice isoforms for PIBF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIBF1 Gene

Post-translational modifications for PIBF1 Gene

  • Ubiquitination at Lys 490
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for PIBF1

No data available for DME Specific Peptides for PIBF1 Gene

Domains & Families for PIBF1 Gene

Protein Domains for PIBF1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PIBF1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PIBF1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PIBF1 Gene

Function for PIBF1 Gene

Molecular function for PIBF1 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1: Pericentriolar protein required to maintain mitotic spindle pole integrity (PubMed:21224392). Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation (PubMed:23110211). Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 (PubMed:26297806).
UniProtKB/Swiss-Prot Function:
Isoform 4: The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual naturakl killer cells (NK) activity exerts an anti-abortive effect (PubMed:14634107, PubMed:3863495, PubMed:12516630). Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein (PubMed:16393965, PubMed:25218441).
UniProtKB/Swiss-Prot Induction:
By progesterone.

Gene Ontology (GO) - Molecular Function for PIBF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005136 interleukin-4 receptor binding IDA 16393965
GO:0005515 protein binding IPI 17500595
genes like me logo Genes that share ontologies with PIBF1: view

Phenotypes for PIBF1 Gene

MGI mutant phenotypes for PIBF1:
inferred from 1 alleles
GenomeRNAi human phenotypes for PIBF1:
genes like me logo Genes that share phenotypes with PIBF1: view

Animal Models for PIBF1 Gene

MGI Knock Outs for PIBF1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PIBF1 Gene

Localization for PIBF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIBF1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Secreted. Note=In progesterone-treated astrocytoma cells a 57 kDa protein and isoform 1 (90 kDa) have been described, both being located in the intracellular medium and secreted. Respective predominant forms are isoform 1 in the intracellular and the 57 kDa protein in the extracellular medium (PubMed:25218441). {ECO:0000269 PubMed:25218441}.
Isoform 1: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Secreted. Note=Localizes to centriolar satellites throughout the cell cycle. {ECO:0000269 PubMed:26297806}.
Isoform 4: Secreted. Note=Secreted by progesterone-treated lymphocytes (PubMed:14634107). {ECO:0000269 PubMed:14634107}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIBF1 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 4
plasma membrane 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PIBF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 14634107
GO:0005634 nucleus IEA,IDA 14634107
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
genes like me logo Genes that share ontologies with PIBF1: view

Pathways & Interactions for PIBF1 Gene

SuperPathways for PIBF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PIBF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0007080 mitotic metaphase plate congression IMP 21224392
GO:0010531 activation of JAK1 kinase activity IDA 16393965
GO:0031393 negative regulation of prostaglandin biosynthetic process IDA 3863495
GO:0032695 negative regulation of interleukin-12 production IDA 14634107
genes like me logo Genes that share ontologies with PIBF1: view

No data available for Pathways by source and SIGNOR curated interactions for PIBF1 Gene

Drugs & Compounds for PIBF1 Gene

(4) Drugs for PIBF1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PIBF1: view

Transcripts for PIBF1 Gene

Unigene Clusters for PIBF1 Gene

Progesterone immunomodulatory binding factor 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIBF1 Gene

No ASD Table

Relevant External Links for PIBF1 Gene

GeneLoc Exon Structure for
PIBF1
ECgene alternative splicing isoforms for
PIBF1

Expression for PIBF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PIBF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PIBF1 Gene

This gene is overexpressed in Cerebrospinal fluid (23.9), Liver, secretome (17.7), Testis (10.0), and Urine (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PIBF1 Gene



NURSA nuclear receptor signaling pathways regulating expression of PIBF1 Gene:

PIBF1

SOURCE GeneReport for Unigene cluster for PIBF1 Gene:

Hs.441926

mRNA Expression by UniProt/SwissProt for PIBF1 Gene:

Q8WXW3-PIBF1_HUMAN
Tissue specificity: Expressed at highest levels in testis. Moderate expression is detected in spleen, thymus, prostate, ovary, small intestine, and colon (PubMed:11935316). Expressed in the first trimester pregnancy decidua (PubMed:12516630). Localized to extravillous cytotrophoblast (at protein level). Also found in syncytiotrophoblast and part of the villous cytotrophoblast. Isoform 1 is expressed in first trimester and term villous trophoblast; trophoblast cells can additionally express other isoforms (PubMed:18817979). Overexpresed in solid tumors from stomach and uterus and in cells from ovary, cervical, breast, lymphoma and leukemia cancer (PubMed:25218441).
genes like me logo Genes that share expression patterns with PIBF1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for PIBF1 Gene

Orthologs for PIBF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PIBF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIBF1 34 35
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia PIBF1 34 35
  • 92.03 (n)
cow
(Bos Taurus)
Mammalia PIBF1 34 35
  • 91.19 (n)
rat
(Rattus norvegicus)
Mammalia Pibf1 34
  • 86.66 (n)
mouse
(Mus musculus)
Mammalia Pibf1 34 16 35
  • 86.42 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PIBF1 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIBF1 34 35
  • 75.17 (n)
lizard
(Anolis carolinensis)
Reptilia PIBF1 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pibf1 34
  • 70.41 (n)
Str.19453 34
zebrafish
(Danio rerio)
Actinopterygii pibf1 34 35
  • 65.5 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToOne
Species where no ortholog for PIBF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PIBF1 Gene

ENSEMBL:
Gene Tree for PIBF1 (if available)
TreeFam:
Gene Tree for PIBF1 (if available)

Paralogs for PIBF1 Gene

No data available for Paralogs for PIBF1 Gene

Variants for PIBF1 Gene

Sequence variations from dbSNP and Humsavar for PIBF1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs17089782 Likely pathogenic 72,835,359(+) TGAAC(A/G)AGAAA nc-transcript-variant, reference, missense
rs863225214 Likely pathogenic 72,917,105(+) GGGTT(-/C)TTTTT nc-transcript-variant, reference, frameshift-variant
rs1000973 -- 72,981,494(+) GAATA(A/G)AAAAA intron-variant
rs1029092 -- 73,000,276(+) TTTGT(C/G)TTGAA intron-variant
rs1029093 -- 73,001,317(+) TACCA(C/T)GCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIBF1 Gene

Variant ID Type Subtype PubMed ID
esv3580764 CNV loss 25503493
esv3580765 CNV loss 25503493
nsv517408 CNV loss 19592680
nsv1085 CNV insertion 18451855
nsv1049859 CNV loss 25217958

Variation tolerance for PIBF1 Gene

Residual Variation Intolerance Score: 26.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.08; 68.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIBF1 Gene

Human Gene Mutation Database (HGMD)
PIBF1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIBF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIBF1 Gene

Disorders for PIBF1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PIBF1 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
breast lymphoma
  • lymphoma of breast
pregnancy loss, recurrent 1
  • pregnancy loss, recurrent, 1
- elite association - COSMIC cancer census association via MalaCards
Search PIBF1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PIBF1_HUMAN
  • Note=May be associated with microcephaly. {ECO:0000305 PubMed:26297806}.

Relevant External Links for PIBF1

Genetic Association Database (GAD)
PIBF1
Human Genome Epidemiology (HuGE) Navigator
PIBF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIBF1
genes like me logo Genes that share disorders with PIBF1: view

No data available for Genatlas for PIBF1 Gene

Publications for PIBF1 Gene

  1. Progesterone-induced blocking factor activates STAT6 via binding to a novel IL-4 receptor. (PMID: 16393965) Kozma N. … Szekeres-Bartho J. (J. Immunol. 2006) 3 4 22 64
  2. Urinary progesterone-induced blocking factor concentration is related to pregnancy outcome. (PMID: 15269099) PolgA!r B. … Szekeres-BarthA^ J. (Biol. Reprod. 2004) 3 4 22 64
  3. PIBF (progesterone induced blocking factor) is overexpressed in highly proliferating cells and associated with the centrosome. (PMID: 15305375) Lachmann M. … Nagy E. (Int. J. Cancer 2004) 3 4 22 64
  4. Molecular cloning and immunologic characterization of a novel cDNA coding for progesterone-induced blocking factor. (PMID: 14634107) Polgar B. … Paar G. (J. Immunol. 2003) 3 4 22 64
  5. A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes. (PMID: 11935316) Rozenblum E. … Kallioniemi O.-P. (Hum. Genet. 2002) 2 3 4 64

Products for PIBF1 Gene

Sources for PIBF1 Gene

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