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PIBF1 Gene

protein-coding   GIFtS: 53
GCID: GC13P073356

Progesterone Immunomodulatory Binding Factor 1

(Previous name: chromosome 13 open reading frame 24)
(Previous symbol: C13orf24)
  Search for PIBF1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Progesterone Immunomodulatory Binding Factor 11 2     Chromosome 13 Open Reading Frame 241
C13orf241 2 3     CEP902
Progesterone-Induced Blocking Factor 11 2     Progesterone-Induced-Blocking Factor 12
PIBF2 3     

External Ids:    HGNC: 233521   Entrez Gene: 104642   Ensembl: ENSG000000835357   OMIM: 6075325   UniProtKB: Q8WXW33   

Export aliases for PIBF1 gene to outside databases

Previous GC identifers: GC13P071323 GC13P067351 GC13P072292 GC13P071154 GC13P072255 GC13P054053


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PIBF1 Gene:
PIBF1 (progesterone immunomodulatory binding factor 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: PIBF1_HUMAN, Q8WXW3
Function: Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid
metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect

Gene Wiki entry for PIBF1 (C13orf24) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PIBF1 gene promoter:
         AhR   p53   Pax-5   GATA-3   Brachyury   POU6F1 (c2)   Arnt   GATA-2   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIBF1 promoter sequence
   Search Chromatin IP Primers for PIBF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIBF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q22.1   Ensembl cytogenetic band:  13q22.1   HGNC cytogenetic band: 13q21.33

PIBF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIBF1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P073356:  view genomic region     (about GC identifiers)

Start:
73,356,197 bp from pter      End:
73,590,592 bp from pter
Size:
234,396 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PIBF1_HUMAN, Q8WXW3 (See protein sequence)
Recommended Name: Progesterone-induced-blocking factor 1  
Size: 757 amino acids; 89805 Da
Secondary accessions: O95664 Q6U9V2 Q6UG50 Q86V07 Q96SF4
Alternative splicing: 3 isoforms:  Q8WXW3-1   Q8WXW3-2   Q8WXW3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PIBF1: NX_Q8WXW3

Explore proteomics data for PIBF1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys490
  • Modification sites at PhosphoSitePlus

  • See PIBF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006337.2  
    ENSEMBL proteins: 
     ENSP00000317144  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026205 PIBF1

    Graphical View of Domain Structure for InterPro Entry Q8WXW3

    ProtoNet protein and cluster: Q8WXW3

    1 Blocks protein domain: IPB011072 Protein kinase PKN/PRK1


    Find genes that share domains with PIBF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIBF1_HUMAN, Q8WXW3
    Function: Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid
    metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect
    Induction: By progesterone

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17500595
         
    Find genes that share ontologies with PIBF1           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Pibf1 (no phenotypes)

    Find genes that share phenotypes with PIBF1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PIBF1
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    SwitchGear 3'UTR luciferase reporter plasmidPIBF1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus3
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome IDA--
    GO:0016020membrane ----

    Find genes that share ontologies with PIBF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PIBF1
    Interactions:

        Search GeneGlobe Interaction Network for PIBF1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for PIBF1 (Q8WXW33 ENSP000003171444) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K2Q9Y2U53, ENSP000003434634I2D: score=3 STRING: ENSP00000343463
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016192vesicle-mediated transport ----

    Find genes that share ontologies with PIBF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PIBF1

    4 Novoseek inferred chemical compound relationships for PIBF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dydrogesterone 83.2 6 15760377 (2), 16318978 (1), 16188436 (1), 16045524 (1)
    progesterone 75.9 90 12516630 (6), 17701593 (4), 18225679 (3), 16129958 (3) (see all 38)
    mifepristone 62.3 8 17701593 (3), 18225679 (2), 20150625 (1), 16147850 (1)
    arachidonic acid 27.6 5 12733588 (2), 11407300 (1), 16129958 (1)



    Find genes that share compounds with PIBF1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PIBF1 gene: 
    NM_006346.2  

    Unigene Cluster for PIBF1:

    Progesterone immunomodulatory binding factor 1
    Hs.441926  [show with all ESTs]
    Unigene Representative Sequence: AF330046
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326291(uc010aeo.1 uc001vjb.3 uc001vjc.3 uc010aep.3)
    ENST00000489797 ENST00000492803 ENST00000486330 ENST00000489922 ENST00000469712

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate PIBF1:
    hsa-miR-3121-3p hsa-miR-32* hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidPIBF1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PIBF1
      QuantiFast Probe-based Assays in human, mouse, rat PIBF1

    Additional mRNA sequence: 

    AF330046.1 AK309828.1 AY370776.1 AY375528.1 BC006009.1 BC008432.1 BC041806.1 BC051911.1 

    10 DOTS entries:

    DT.112184  DT.95370271  DT.99980969  DT.120765204  DT.40245448  DT.91770213  DT.97841789  DT.100695352 
    DT.120765064  DT.40131159 

    Selected AceView cDNA sequences (see all 151):

    AA251149 BM795456 BC006009 AI200713 AA251594 AI915158 BC008432 BC051911 
    BM714785 AY375528 BM927184 BM763165 AA603710 CR618612 AW273347 BU678150 
    BG492947 AA610068 BX487000 AI741044 NM_006346 AI758409 BU786299 AF330046 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PIBF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGATGGATA
    PIBF1 Expression
    About this image


    PIBF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Testis (Reproductive System)
    PIBF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIBF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.441926

    UniProtKB/Swiss-Prot: PIBF1_HUMAN, Q8WXW3
    Tissue specificity: Expressed at highest levels in testis. Moderate expression is detected in spleen, thymus,
    prostate, ovary, small intestine, and colon

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PIBF1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pibf11 , 5 progesterone immunomodulatory binding factor 11, 5 86.42(n)1
    88.89(a)1
      14 (49.27 cM)5
    520231  NM_029320.31  NP_083596.21 
     990994335 
    chicken
    (Gallus gallus)
    Aves PIBF11 progesterone immunomodulatory binding factor 1 75.17(n)
    75.56(a)
      418820  XM_417014.4  XP_417014.2 
    lizard
    (Anolis carolinensis)
    Reptilia PIBF16
    progesterone immunomodulatory binding factor 1
    75(a)
    1 ↔ 1
    3(88476851-88594866)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.194532 Transcribed sequence with weak similarity to protein more 74.59(n)    BX779065.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pibf11 progesterone immunomodulatory binding factor 1 65.5(n)
    66.04(a)
      445181  NM_001003575.1  NP_001003575.1 


    ENSEMBL Gene Tree for PIBF1 (if available)
    TreeFam Gene Tree for PIBF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PIBF1 (see all 4562)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs672112381,2
    C--54425739(+) TTTTT-/TTGAGAT 1 -- int11Minor allele frequency- TT:0.00NA 2
    rs558772451,2
    C--54481517(+) AAAAA-/A/AA  
            
    TGTCA
    1 -- int11NA 2
    rs1850981671,2
    --73358373(+) AGTTTA/GAGACC 1 -- int10--------
    rs58046461,2
    C--73358414(+) AAAAAA/-TTAGC 1 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs1380252241,2
    --73358532(+) TGAGCC/TACAAT 1 -- int10--------
    rs1433725151,2
    --73358611(+) ATAATC/TGGAGG 1 -- int10--------
    rs1471532871,2
    --73358758(+) CCGCGC/TAGTGG 1 -- int10--------
    rs1165544871,2
    F--73358946(+) TAAACG/ATAGAT 1 -- int11Minor allele frequency- A:0.04WA 118
    rs1899059301,2
    --73358978(+) GCTCAA/TTTTAA 1 -- int10--------
    rs1486888831,2
    C--73359000(+) TATGAA/GGTATT 1 -- int10--------

    HapMap Linkage Disequilibrium report for PIBF1 (73356197 - 73590592 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PIBF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1085CNV Insertion18451855
    nsv517408CNV Loss19592680
    nsv900551CNV Loss21882294

    Human Gene Mutation Database (HGMD): PIBF1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PIBF1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607532    OMIM disorders: --


    Find genes that share disorders with PIBF1           About GenesLikeMe

    5 Novoseek inferred disease relationships for PIBF1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    abortion threatened 81.1 1 19290853 (1)
    miscarriage recurrent 70 1 19371956 (1)
    miscarriage 66.6 10 9161642 (2), 19290853 (2), 15864927 (2), 14634107 (1)
    preterm delivery 48.1 1 19371956 (1)
    tumors 0 14 15305375 (4), 11516226 (3), 18225679 (1)

    Genetic Association Database (GAD): PIBF1
    Human Genome Epidemiology (HuGE) Navigator: PIBF1 (1 document)

    Export disorders for PIBF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIBF1 gene, integrated from 10 sources (see all 76):
    (articles sorted by number of sources associating them with PIBF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes. (PubMed id 11935316)1, 2, 3 Rozenblum E....Kallioniemi O.-P. (Hum. Genet. 2002)
    2. PIBF (progesterone induced blocking factor) is overexpressed in highly proliferating cells and associated with the centrosome. (PubMed id 15305375)1, 2, 9 Lachmann M.... Nagy E. (Int. J. Cancer 2004)
    3. Progesterone as an immunomodulatory molecule. (PubMed id 11407300)1, 2, 9 Szekeres-Bartho J....Szereday L. (Int. Immunopharmacol. 2001)
    4. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. (PubMed id 19898481)1, 4 Raychaudhuri S....Plenge R.M. (Nat. Genet. 2009)
    5. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Urinary progesterone-induced blocking factor concentration is related to pregnancy outcome. (PubMed id 15269099)1, 9 PolgA!r B....Szekeres-BarthA^ J. (Biol. Reprod. 2004)
    8. Molecular cloning and immunologic characterization of a novel cDNA coding for progesterone-induced blocking factor. (PubMed id 14634107)1, 9 Polgar B....Paar G. (J. Immunol. 2003)
    9. Lymphocyte immunotherapy (LI) increases serum levels of progesterone induced blocking factor (PIBF). (PubMed id 9138449)1, 9 Check J.H....Szekeres-Bartho J. (Am. J. Reprod. Immunol. 1997)
    10. Progesterone-induced blocking factor (PIBF) modulates cytokine production by lymphocytes from women with recurrent miscarriage or preterm delivery. (PubMed id 19371956)1, 9 Raghupathy R....Szekeres-Bartho J. (J. Reprod. Immunol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10464 HGNC: 23352 AceView: C13orf24 Ensembl:ENSG00000083535 euGenes: HUgn10464
    ECgene: PIBF1 H-InvDB: PIBF1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PIBF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PIBF1 gene:
    Search GeneIP for patents involving PIBF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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