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PIAS3 Gene

protein-coding   GIFtS: 62
GCID: GC01P145575

Protein Inhibitor Of Activated STAT, 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Inhibitor Of Activated STAT, 31 2     ZMIZ52
Protein Inhibitor Of Activated STAT Protein 32 3     E3 SUMO-Protein Ligase PIAS32
MIZ-Type Containing 51     Zinc Finger, MIZ-Type Containing 52
Zinc Finger1     EC 6.3.2.-3

External Ids:    HGNC: 168611   Entrez Gene: 104012   Ensembl: ENSG000001317887   OMIM: 6059875   UniProtKB: Q9Y6X23   

Export aliases for PIAS3 gene to outside databases

Previous GC identifers: GC01P144096 GC01P142163 GC01P143302 GC01P143324 GC01P143065 GC01P144287 GC01P119540


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PIAS3 Gene:
This gene encodes a member of the PIAS (protein inhibitor of activated STAT (signal transducer and activator of
transcription)) family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like
modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It
directly binds to several transcription factors and either blocks or enhances their activity. Alternatively
spliced transcript variants of this gene have been identified, but the full-length nature of some of these
variants has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for PIAS3 Gene:
PIAS3 (protein inhibitor of activated STAT, 3) is a protein-coding gene. GO annotations related to this gene include protein C-terminus binding and nucleic acid binding. An important paralog of this gene is ZMIZ2.

UniProtKB/Swiss-Prot: PIAS3_HUMAN, Q9Y6X2
Function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between
UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation
in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in
regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth

Gene Wiki entry for PIAS3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the PIAS3 gene promoter:
         TBP   MAZR   HTF   E47   GATA-1   GATA-2   YY1   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIAS3 promoter sequence
   Search Chromatin IP Primers for PIAS3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIAS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.1   HGNC cytogenetic band: 1q21

PIAS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIAS3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P145575:  view genomic region     (about GC identifiers)

Start:
145,575,233 bp from pter      End:
145,586,546 bp from pter
Size:
11,314 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PIAS3_HUMAN, Q9Y6X2 (See protein sequence)
Recommended Name: E3 SUMO-protein ligase PIAS3  
Size: 628 amino acids; 68017 Da
Subunit: Monomer (By similarity). Binds SUMO1 and UBE2I. Interacts with BCL11A, HMGA2, IRF1, MITF and NCOA2.
Interacts with STAT5; the interaction occurs on stimulation by PRL. Interacts with GFI1; the interaction relieves
the inhibitory effect of PIAS3 on STAT3-mediated transcriptional activity (By similarity). Interacts with AR,
PLAG1 and ZFHX3. Interacts with STAT3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the
DNA binding activity of STAT3
Sequence caution: Sequence=BAA78533.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for PIAS3:
4MVT (3D)    
Secondary accessions: Q9UFI3

Explore the universe of human proteins at neXtProt for PIAS3: NX_Q9Y6X2

Explore proteomics data for PIAS3 at MOPED

Post-translational modifications: 

  • Sumoylated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PIAS3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006090.2  
    ENSEMBL proteins: 
     ENSP00000376766   ENSP00000476245   ENSP00000376765   ENSP00000358304   ENSP00000358305  

    PIAS3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PIAS3

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZMIZ: Zinc fingers, MIZ-type

    4 InterPro protein domains:
     IPR027226 PIAS3
     IPR004181 Znf_MIZ
     IPR003034 SAP_dom
     IPR023321 PINIT

    Graphical View of Domain Structure for InterPro Entry Q9Y6X2

    ProtoNet protein and cluster: Q9Y6X2

    2 Blocks protein domains:
    IPB003034 DNA-binding SAP
    IPB004181 Zn-finger


    UniProtKB/Swiss-Prot: PIAS3_HUMAN, Q9Y6X2
    Domain: The PINIT domain of PIAS3 is required for STAT3-PIAS3 interaction and for transloaction to the nucleus
    Domain: The LXXLL motif is a transcriptional coregulator signature
    Similarity: Belongs to the PIAS family
    Similarity: Contains 1 PINIT domain
    Similarity: Contains 1 SAP domain
    Similarity: Contains 1 SP-RING-type zinc finger


    Find genes that share domains with PIAS3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIAS3_HUMAN, Q9Y6X2
    Function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between
    UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation
    in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in
    regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth
    Induction: By dihydrotestosterone (DHT) in prostate cancer cells

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0005515protein binding IPI11060035
    GO:0008022protein C-terminus binding IPI14715251
    GO:0008270zinc ion binding IEA--
    GO:0015459potassium channel regulator activity IEA--
         
    Find genes that share ontologies with PIAS3           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PIAS3
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    miRNA
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    hsa-mir-10a-5p (MIRT047704), hsa-mir-21-5p (MIRT006288)

    Block miRNA regulation of human, mouse, rat PIAS3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PIAS3 (see all 41):
    hsa-miR-548j hsa-miR-3142 hsa-miR-9 hsa-miR-298 hsa-miR-3613-3p hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-4309
    SwitchGear 3'UTR luciferase reporter plasmidPIAS3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PIAS3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: PIAS3 (NM_006099)
    Sino Biological Human cDNA Clone for PIAS3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIAS3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIAS3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PIAS3_HUMAN, Q9Y6X2: Cytoplasm. Nucleus. Note=Mainly cytoplasmic but shuttles between the nucleus and cytoplasm.
    Transported to the nucleus on interaction with phosphorylated STAT3. Colocalizes with GFI1 in nuclear dots (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0030425dendrite IEA--
    GO:0045202synapse IEA--

    Find genes that share ontologies with PIAS3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PIAS3 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Jak/Stat Pathway
    Development Thrombopoetin signaling via JAK STAT pathway0.32
    Jak/Stat Pathway0.32
    2PEDF Induced Signaling
    IL-6 Pathway0.61
    3TGF-Beta Pathway
    JAK-STAT Pathway0.57
    4Prolactin Signaling Pathway
    Prolactin Signaling Pathway0.39
    5G protein signaling Ras family GTPases in kinase cascades scheme
    Oncostatin M Signaling Pathway0.37


    Find genes that share SuperPaths with PIAS3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PIAS3
        JAK-STAT Pathway
    IL-6 Pathway

    1 Cell Signaling Technology (CST) Pathway for PIAS3
        Jak/Stat Pathway

    2 GeneGo (Thomson Reuters) Pathways for PIAS3
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Development Thrombopoetin signaling via JAK-STAT pathway

    Selected BioSystems Pathways for PIAS3 (see all 10)
        Oncostatin M Signaling Pathway
    Interferon type I
    Androgen receptor signaling pathway
    TNF-alpha/NF-kB Signaling Pathway
    Interleukin-11 Signaling Pathway



    2 Kegg Pathways  (Kegg details for PIAS3):
        Ubiquitin mediated proteolysis
    Jak-STAT signaling pathway

    UniProtKB/Swiss-Prot: PIAS3_HUMAN, Q9Y6X2
    Pathway: Protein modification; protein sumoylation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PIAS3
    Interactions:

        GeneGlobe Interaction Network for PIAS3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PIAS3 (Q9Y6X21, 2, 3 ENSP000003767654) via UniProtKB, MINT, STRING, and/or I2D (see all 168)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    C19orf60Q96EN92, 3, ENSP000003514224MINT-8266106 I2D: score=2 STRING: ENSP00000351422
    PSMC1P621912, 3, ENSP000002613034MINT-8266128 I2D: score=2 STRING: ENSP00000261303
    ATF7IPQ6VMQ62, 3MINT-61884 I2D: score=3 
    PRPF40AO754002, 3MINT-61845 I2D: score=3 
    SKILP127572, 3MINT-61630 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0009725response to hormone IEA--
    GO:0010628positive regulation of gene expression IEA--
    GO:0016925protein sumoylation ISS--

    Find genes that share ontologies with PIAS3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PIAS3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PIAS3 gene: 
    NM_006099.3  

    Unigene Cluster for PIAS3:

    Protein inhibitor of activated STAT, 3
    Hs.435761  [show with all ESTs]
    Unigene Representative Sequence: BC030556
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393046 ENST00000463514 ENST00000393045(uc001eoc.1) ENST00000369298
    ENST00000484423 ENST00000498436 ENST00000475261(uc001eod.1) ENST00000472114
    ENST00000369299(uc010oyy.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PIAS3 (see all 41):
    hsa-miR-548j hsa-miR-3142 hsa-miR-9 hsa-miR-298 hsa-miR-3613-3p hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-4309
    SwitchGear 3'UTR luciferase reporter plasmidPIAS3 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: PIAS3 (NM_006099)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat PIAS3
      QuantiFast Probe-based Assays in human, mouse, rat PIAS3

    Additional mRNA sequence: 

    AB021868.1 AK027557.1 AK294231.1 AK304039.1 AL122061.1 BC001154.1 BC030556.1 BT007036.1 
    CR457090.1 

    12 DOTS entries:

    DT.444950  DT.95297810  DT.95073200  DT.95072139  DT.86857437  DT.121360682  DT.95073199  DT.95239075 
    DT.121360641  DT.121360655  DT.95073202  DT.99941193 

    Selected AceView cDNA sequences (see all 208):

    BQ436701 CB158728 BC030556 AL582931 CA489770 BQ921259 CA396111 BU183507 
    BQ921265 AK125158 AU118455 BI823858 BM701760 CB156534 AU279846 BM715935 
    AA375243 BP366023 BU178124 BE784472 AW297008 BI488513 BP365437 BU508963 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PIAS3 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^
    SP1:                                                        -     -     -                             -           -                                             
    SP2:                                                                                                  -           -                                   -         
    SP3:                                                                                                                                                  -         
    SP4:              -     -     -     -     -                 -     -     -                                                                                       
    SP5:                          -     -     -                 -     -     -                                                                                       

    ExUns: 15a · 15b ^ 16a · 16b · 16c ^ 17a · 17b
    SP1:  -                 -     -               
    SP2:                                          
    SP3:  -                 -     -               
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for PIAS3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PIAS3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCTGTAGT
    PIAS3 Expression
    About this image


    PIAS3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neurons
             Rod Precursor Cells Outer Nuclear Layer
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Rod Precursor Cells Outer Nuclear Layer
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Limb (Muscoskeletal System)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
    PIAS3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIAS3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435761

    UniProtKB/Swiss-Prot: PIAS3_HUMAN, Q9Y6X2
    Tissue specificity: Isoform 1 is expressed in most tissues except thymus and small intestine. Isoform 3 is
    expressed only in brain, heart, thymus, muscle, lung, testis, lactating breast and embryonic stem cells

        Custom PCR Arrays for PIAS3
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    QuantiFast Probe-based Assays in human, mouse, rat PIAS3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIAS3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PIAS3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pias31 , 5 protein inhibitor of activated STAT 31, 5 90.39(n)1
    96.97(a)1
      3 (41.95 cM)5
    2296151  NM_001165949.11  NP_001159421.11 
     966963845 
    chicken
    (Gallus gallus)
    Aves PIAS36
    protein inhibitor of activated STAT, 3
    59(a)
    1 ↔ 1
    25(645944-647516)
    lizard
    (Anolis carolinensis)
    Reptilia PIAS36
    protein inhibitor of activated STAT, 3
    66(a)
    1 ↔ 1
    AAWZ02037198(80-14535)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pias31 protein inhibitor of activated STAT, 3 69.57(n)
    74.71(a)
      100144644  NM_001123418.1  NP_001116890.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Su(var)2-103 chromosome condensation DNA binding 44(a)   2 45A8   --
    worm
    (Caenorhabditis elegans)
    Secernentea gei-173   -- 36(a)
    (best of 3)
      I(9109589-9115598)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NFI16
    SIZ16
    SUMO E3 ligase, catalyzes the covalent attachment ...
    SUMO/Smt3 ligase that promotes the attachment of s...
    14(a)
    11(a)
    many ↔ many
    many ↔ many
    XV(628360-630540) YOR156C
    IV(1289406-1292120) YDR409W


    ENSEMBL Gene Tree for PIAS3 (if available)
    TreeFam Gene Tree for PIAS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PIAS3 gene
    ZMIZ22  PIAS12  PIAS22  ZMIZ12  PIAS42  
    5 SIMAP similar genes for PIAS3 using alignment to 6 protein entries:     PIAS3_HUMAN (see all proteins):
    DKFZp727A051    PIAS1    PIAS2    DKFZp434O0617    PIAS4

    Find genes that share paralogs with PIAS3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for PIAS3 (see all 307)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1147200261,2
    C,F--145574047(+) GTTCAA/GCTGGC 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1401819841,2
    --145574069(+) TTGGCC/TTGGGT 1 -- us2k10--------
    rs1453782061,2
    --145574121(+) TAAAAA/GGATTT 1 -- us2k10--------
    rs75497131,2
    C--145574233(+) AGCACC/TTAATG 1 -- us2k10--------
    rs358605131,2
    C--145574275(+) CAAAT-/ATGCAG 1 -- us2k12Minor allele frequency- A:0.25NA 4
    rs1451717901,2
    --145574284(+) AGCCAA/GCTATA 1 -- us2k10--------
    rs729959481,2
    C,F--145574318(+) GTAGTG/ACGGGT 1 -- us2k12Minor allele frequency- A:0.04WA 120
    rs1491300931,2
    --145574400(+) GGCCAA/GGGTGA 1 -- us2k10--------
    rs1423575781,2
    --145574561(+) ACCCGC/GGGGGC 1 -- us2k10--------
    rs752488081,2
    C--145574636(+) CCCCCA/CCCAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PIAS3 (145575233 - 145586546 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PIAS3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv15n16CNV Deletion17901297
    dgv46e201CNV Deletion23290073
    esv2422428CNV Duplication17116639
    nsv872232CNV Gain21882294
    dgv347n71CNV Gain21882294
    nsv831381CNV Gain17160897
    nsv831370CNV Gain17160897
    nsv7181OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PIAS3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 605987    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for PIAS3:
    Microphthalmia

    Find genes that share disorders with PIAS3           About GenesLikeMe

    1 Novoseek inferred disease relationship for PIAS3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 11.9 2 15138572 (1), 11071847 (1)


    Export disorders for PIAS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIAS3 gene, integrated from 10 sources (see all 81):
    (articles sorted by number of sources associating them with PIAS3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and chromosomal assignment of a human gene encoding protein inhibitor of activated STAT3 (PIAS3). (PubMed id 10319586)1, 2, 3 Ueki N.... Muramatsu M.-A. (J. Hum. Genet. 1999)
    2. Specific inhibition of Stat3 signal transduction by PIAS3. (PubMed id 9388184)1, 2, 9 Chung C.D.... Shuai K. (Science 1997)
    3. Protein inhibitor of activated STAT3 regulates androgen receptor signaling in prostate carcinoma cells. (PubMed id 11071847)1, 2, 9 Junicho A.... Muraguchi A. (Biochem. Biophys. Res. Commun. 2000)
    4. ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3. (PubMed id 14715251)1, 2 Nojiri S.... Ito M. (Biochem. Biophys. Res. Commun. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3. (PubMed id 11060035)1, 2 Roedel B.... Moeroey T. (EMBO J. 2000)
    7. Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3). (PubMed id 14691252)1, 9 Long J....Liu F. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    8. The association and nuclear translocation of the PIAS3-STAT3 complex is ligand and time dependent. (PubMed id 19903771)1, 9 Dabir S....Dowlati A. (Mol. Cancer Res. 2009)
    9. Identifying a common molecular mechanism for inhibition of MITF and STAT3 by PIAS3. (PubMed id 16368885)1, 9 Levy C....Razin E. (Blood 2006)
    10. Differential PIAS3 expression in human malignancy. (PubMed id 15138572)1, 9 Wang L. and Banerjee S. (Oncol. Rep. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10401 HGNC: 16861 AceView: PIAS3 Ensembl:ENSG00000131788 euGenes: HUgn10401
    ECgene: PIAS3 Kegg: 10401 H-InvDB: PIAS3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PIAS3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PIAS3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PIAS3 gene:
    Search GeneIP for patents involving PIAS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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