Aliases for PIAS3 Gene
Aliases for PIAS3 Gene
External Ids for PIAS3 Gene
- HGNC: 16861
- Entrez Gene: 10401
- Ensembl: ENSG00000131788
- OMIM: 605987
- UniProtKB: Q9Y6X2
Previous GeneCards Identifiers for PIAS3 Gene
- GC01P144096
- GC01P142163
- GC01P143302
- GC01P143324
- GC01P143065
- GC01P144287
- GC01P145575
- GC01P119540
Summaries for PIAS3 Gene
-
This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for PIAS3 Gene
PIAS3 (Protein Inhibitor Of Activated STAT 3) is a Protein Coding gene. Among its related pathways are Development_Leptin signaling via JAK/STAT and MAPK cascades and C-MYB transcription factor network. GO annotations related to this gene include nucleic acid binding and ligase activity. An important paralog of this gene is PIAS1.
UniProtKB/Swiss-Prot for PIAS3 Gene
-
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIAS3 Gene
Genomics for PIAS3 Gene
Regulatory Elements for PIAS3 Gene
Enhancers for PIAS3 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G145781 | 1.2 | Ensembl ENCODE | 6.2 | +77.2 | 77182 | 2.3 | TBP INSM2 ZBTB40 RAD21 ZEB1 RFX5 GTF3C2 POLR3A ZNF366 RCOR1 | POLR3C NUDT17 GNRHR2 PDZK1 CD160 PIAS3 ANKRD35 PIR35710 PIR40983 |
| GH01G145844 | 1.1 | ENCODE | 6.4 | +14.0 | 13979 | 1.9 | HDGF PKNOX1 FOXA2 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B | NUDT17 ITGA10 PEX11B TXNIP CD160 PIAS3 MIR6736 |
| GH01G145858 | 1.1 | ENCODE | 5.5 | +0.6 | 586 | 2.4 | HDGF ARID4B SIN3A ZNF2 ZBTB7B YY1 CBX5 ZNF143 KLF13 SP3 | ANKRD35 POLR3C ITGA10 PEX11B GNRHR2 PIAS3 PIR43682 |
| GH01G145823 | 1.1 | ENCODE | 4.6 | +35.5 | 35494 | 1.7 | HDGF PKNOX1 MLX CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A YBX1 | NUDT17 PIAS3 RNF115 |
| GH01G145688 | 1.1 | Ensembl ENCODE | 4 | +169.8 | 169753 | 3.5 | HDAC1 FOXA2 RAD21 SCRT2 FOS RELB IKZF2 HMG20B CEBPB REST | ENSG00000213240 PIAS3 PDZK1 GPR89A |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around PIAS3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PIAS3 gene promoter:
Regulatory Element Products
Genomic Location for PIAS3 Gene
- Chromosome:
- 1
- Start:
- 145,848,522 bp from pter
- End:
- 145,859,836 bp from pter
- Size:
- 11,315 bases
- Orientation:
- Minus strand
Genomic View for PIAS3 Gene
Genes around PIAS3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.1 by Ensembl
- 1q21.1 by Entrez Gene
- 1q21.1 by HGNC
PIAS3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PIAS3 Gene
Proteins for PIAS3 Gene
-
Protein details for PIAS3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6X2-PIAS3_HUMAN
- Recommended name:
- E3 SUMO-protein ligase PIAS3
- Protein Accession:
- Q9Y6X2
- Q9UFI3
Protein attributes for PIAS3 Gene
- Size:
- 628 amino acids
- Molecular mass:
- 68017 Da
- Quaternary structure:
-
- Monomer (By similarity). Binds SUMO1 and UBE2I. Interacts with BCL11A, HMGA2, IRF1, MITF and NCOA2. Interacts with STAT5; the interaction occurs on stimulation by PRL. Interacts with GFI1; the interaction relieves the inhibitory effect of PIAS3 on STAT3-mediated transcriptional activity (By similarity). Interacts with AR, PLAG1 and ZFHX3. Interacts with STAT3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3. Interacts with MTA1. Interacts with CCAR2 (via N-terminus).
- SequenceCaution:
-
- Sequence=BAA78533.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for PIAS3 Gene
Post-translational modifications for PIAS3 Gene
- Sumoylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PIAS3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PIAS3 (PIAS3)
- Cell Signaling Technology (CST) Antibodies for PIAS3 (PIAS3)
-
Custom Antibody ServicesOriGene Antibodies for PIAS3
- Novus Biologicals Antibodies for PIAS3
-
Abcam antibodies for PIAS3
-
Cloud-Clone Corp. Antibodies for PIAS3
- Invitrogen Antibodies for PIAS3
- antibodies-online Antibodies for PIAS3: See all 59
- GeneTex PIAS3 antibody for PIAS3
-
Custom Antibody ServicesProSci Antibodies for PIAS3
-
Santa Cruz Biotechnology (SCBT) Antibodies for PIAS3
Protein Products
-
OriGene Purified Proteins for PIAS3
- Search Origene for MassSpec and Protein Over-expression Lysates for PIAS3
- Origene Custom Protein Services for PIAS3
-
Cloud-Clone Corp. Proteins for PIAS3
- antibodies-online Proteins for PIAS3: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for PIAS3
-
Abcam proteins for PIAS3
No data available for DME Specific Peptides for PIAS3 Gene
Domains & Families for PIAS3 Gene
Gene Families for PIAS3 Gene
Protein Domains for PIAS3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PIAS3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y6X2UniProtKB/Swiss-Prot:
PIAS3_HUMAN :- The PINIT domain of PIAS3 is required for STAT3-PIAS3 interaction and for transloaction to the nucleus.
- Belongs to the PIAS family.
- Domain:
-
- The PINIT domain of PIAS3 is required for STAT3-PIAS3 interaction and for transloaction to the nucleus.
- The LXXLL motif is a transcriptional coregulator signature.
- Family:
-
- Belongs to the PIAS family.
Function for PIAS3 Gene
Molecular function for PIAS3 Gene
- UniProtKB/Swiss-Prot Function:
- Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376).
- UniProtKB/Swiss-Prot Induction:
- By dihydrotestosterone (DHT) in prostate cancer cells.
Enzyme Numbers (IUBMB) for PIAS3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 11060035 |
| GO:0008022 | protein C-terminus binding | IPI | 14715251 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0015459 | potassium channel regulator activity | IEA | -- |
| GO:0016874 | ligase activity | IEA | -- |
Phenotypes for PIAS3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PIAS3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PIAS3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PIAS3 gene
- Search ViGene Biosciences for PIAS3
CRISPR Products
-
OriGene CRISPR knockouts for PIAS3
-
Santa Cruz Biotechnology (SCBT) CRISPR for PIAS3
- GenScript: Design CRISPR guide RNA sequences for PIAS3
miRNA for PIAS3 Gene
- miRTarBase miRNAs that target PIAS3
miRNA Products
- Search ViGene Biosciences for PIAS3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for PIAS3
- Browse OriGene Inhibitory RNA Products For PIAS3
-
ViGene Biosciences ready-to-package AAV shRNAs for PIAS3 gene
Clone Products
-
OriGene ORF clones in human for PIAS3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PIAS3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PIAS3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PIAS3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for PIAS3
-
ViGene Biosciences adenoviral particle packaged cDNA for PIAS3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PIAS3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PIAS3 gene
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIAS3 Gene
Localization for PIAS3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PIAS3 Gene
- Cytoplasm. Nucleus. Nucleus speckle. Note=Colocalizes with MITF in the nucleus. Colocalizes with GFI1 in nuclear dots. Colocalizes with SUMO1 in nuclear granules. {ECO:0000250 UniProtKB:O54714}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0016607 | nuclear speck | IEA | -- |
| GO:0030425 | dendrite | IEA | -- |
Pathways & Interactions for PIAS3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | ||
| 2 | SUMOylation |
.95
|
|
| 3 | Metabolism of proteins | ||
| 4 | Jak-STAT signaling pathway (KEGG) | ||
| 5 | Ubiquitin mediated proteolysis | ||
Pathways by source for PIAS3 Gene
1 Sino Biological pathway for PIAS3 Gene
1 Cell Signaling Technology pathway for PIAS3 Gene
10 BioSystems pathways for PIAS3 Gene
10 Reactome pathways for PIAS3 Gene
2 KEGG pathways for PIAS3 Gene
2 GeneGo (Thomson Reuters) pathways for PIAS3 Gene
1 R&D Systems pathway for PIAS3 Gene
2 Qiagen pathways for PIAS3 Gene
UniProtKB/Swiss-Prot Q9Y6X2-PIAS3_HUMAN
- Pathway: Protein modification; protein sumoylation.
Interacting Proteins for PIAS3 Gene
Selected Interacting proteins:
Q9Y6X2-PIAS3_HUMAN
ENSP00000376765
for PIAS3 Gene via
MINT
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0009725 | response to hormone | IEA | -- |
| GO:0010628 | positive regulation of gene expression | IEA | -- |
| GO:0016925 | protein sumoylation | IEA,TAS | -- |
Transcripts for PIAS3 Gene
mRNA/cDNA for PIAS3 Gene
- (1) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (208) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PIAS3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PIAS3
-
Santa Cruz Biotechnology (SCBT) CRISPR for PIAS3
- GenScript: Design CRISPR guide RNA sequences for PIAS3
miRNA Products
- Search ViGene Biosciences for PIAS3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for PIAS3
- Browse OriGene Inhibitory RNA Products For PIAS3
-
ViGene Biosciences ready-to-package AAV shRNAs for PIAS3 gene
Clone Products
-
OriGene ORF clones in human for PIAS3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PIAS3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PIAS3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PIAS3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - |
| ExUns: | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · | 17b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||
| SP2: | |||||||||||||
| SP3: | - | - | - | ||||||||||
| SP4: | |||||||||||||
| SP5: | |||||||||||||
| SP6: | - | ||||||||||||
| SP7: | |||||||||||||
| SP8: | |||||||||||||
| SP9: | |||||||||||||
| SP10: | |||||||||||||
| SP11: | |||||||||||||
| SP12: | |||||||||||||
| SP13: |
Expression for PIAS3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Cone Precursor Cells Outer Nuclear Layer
- Rod Precursor Cells Outer Nuclear Layer
-
Neurons
- Cone Precursor Cells Outer Nuclear Layer
- Rod Precursor Cells Outer Nuclear Layer
- Brain (Nervous System)
-
Limb (Muscoskeletal System)
- Limb Bud Mesenchyme Cells Limb Bud
-
Mesoderm (Gastrulation Derivatives)
- Limb Bud Mesenchyme Cells Limb Bud
This gene is overexpressed in Serum (55.8) and Heart (13.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PIAS3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PIAS3 Gene:
PIAS3SOURCE GeneReport for Unigene cluster for PIAS3 Gene:
Hs.435761mRNA Expression by UniProt/SwissProt for PIAS3 Gene:
Q9Y6X2-PIAS3_HUMAN
Tissue specificity:
Widely expressed.
Evidence on tissue expression from TISSUES for PIAS3 Gene
- Nervous system(4.3)
- Blood(4.2)
- Muscle(4.2)
- Lung(2.2)
- Skin(2)
Primer Products
-
OriGene qPCR primer pairs for PIAS3
-
OriGene qPCR primer pairs and template standards for PIAS3
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIAS3 Gene
Orthologs for PIAS3 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PIAS3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | PIAS3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | PIAS3 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Pias3 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pias3 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PIAS3 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | PIAS3 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PIAS3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pias3 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Su(var)2-10 36 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | gei-17 36 35 |
|
||
| W10D5.3a 36 |
|
|
|||
| W10D5.3d 36 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NFI1 35 |
|
ManyToMany | |
| SIZ1 35 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2754 34 |
|
- Species where no ortholog for PIAS3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- zebrafish (Danio rerio)
Paralogs for PIAS3 Gene
(5) SIMAP similar genes for PIAS3 Gene using alignment to 6 proteins:
Variants for PIAS3 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000988439 | -- | 145,859,234(+) | AGGGA(G/T)TGTAT | upstream-variant-2KB | |
| rs1001131319 | -- | 145,852,874(+) | CAGGT(A/T)GGAGC | intron-variant | |
| rs1001518764 | -- | 145,853,116(+) | AAAAA(A/T)GAAAT | intron-variant | |
| rs1001578931 | -- | 145,854,257(+) | ATTGG(A/G)AATTC | intron-variant | |
| rs1001917674 | -- | 145,852,247(+) | AACGA(A/G)ACCCT | intron-variant, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3587420 | CNV | gain | 21293372 |
| nsv1005055 | CNV | loss | 25217958 |
| nsv1015025 | CNV | gain | 25217958 |
| nsv831381 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
22.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.03;
60.44% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for PIAS3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PIAS3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIAS3 Gene
Disorders for PIAS3 Gene
Relevant External Links for PIAS3
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- PIAS3
No disorders were found for PIAS3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIAS3 Gene
Publications for PIAS3 Gene
- Protein inhibitor of activated STAT3 regulates androgen receptor signaling in prostate carcinoma cells. (PMID: 11071847) Junicho A. … Muraguchi A. (Biochem. Biophys. Res. Commun. 2000) 3 4 22 64
- Isolation and chromosomal assignment of a human gene encoding protein inhibitor of activated STAT3 (PIAS3). (PMID: 10319586) Ueki N. … Muramatsu M.-A. (J. Hum. Genet. 1999) 2 3 4 64
- Specific inhibition of Stat3 signal transduction by PIAS3. (PMID: 9388184) Chung C.D. … Shuai K. (Science 1997) 3 4 22 64
- Characterization of nuclear localization and SUMOylation of the ATBF1 transcription factor in epithelial cells. (PMID: 24651376) Sun X. … Dong J.T. (PLoS ONE 2014) 3 4 64
- SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function. (PMID: 21965678) Cong L. … Kumar R. (J. Biol. Chem. 2011) 3 4 64
Products for PIAS3 Gene
- R&D Systems Antibodies for PIAS3 (PIAS3)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for PIAS3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PIAS3
- Search Origene for MassSpec and Protein Over-expression Lysates for PIAS3
- Origene Custom Protein Services for PIAS3
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for PIAS3
- Browse OriGene Inhibitory RNA Products For PIAS3
- OriGene qPCR primer pairs and template standards for PIAS3
- OriGene qPCR primer pairs for PIAS3
- OriGene CRISPR knockouts for PIAS3
- OriGene ORF clones in human for PIAS3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PIAS3
- GenScript: Next-day shipping cDNA ORF clone for PIAS3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PIAS3
- GenScript Custom Assay Services for PIAS3
- GenScript Custom overexpressing Cell Line Services for PIAS3
- GenScript: Design CRISPR guide RNA sequences for PIAS3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PIAS3
- Cell Signaling Technology (CST) Antibodies for PIAS3 (PIAS3)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for PIAS3
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for PIAS3
- Novus Biologicals proteins and lysates for PIAS3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for PIAS3
- Abcam proteins for PIAS3
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Cloud-Clone Corp. Antibodies for PIAS3
- Cloud-Clone Corp. Proteins for PIAS3
- Cloud-Clone Corp Assay Kits for PIAS3
- Invitrogen Antibodies for PIAS3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for PIAS3: See all 59
- antibodies-online Kits for PIAS3: See all 14
- antibodies-online Proteins for PIAS3: See all 6
- Search antibodies-online for peptides
- GeneTex PIAS3 antibody for PIAS3
- Search GeneTex for Proteins for PIAS3
- ViGene Biosciences adenoviral particle packaged cDNA for PIAS3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PIAS3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PIAS3 gene
- Search ViGene Biosciences for PIAS3
- Santa Cruz Biotechnology (SCBT) Antibodies for PIAS3
- Search Santa Cruz Biotechnology (SCBT) for PIAS3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PIAS3
- Custom Antibody ServicesProSci Antibodies for PIAS3
- Search for PIAS3 Proteins at ProSci
- Horizon Cell Lines for PIAS3
- Cyagen custom Knockout/knockin (KOKI) mouse models for PIAS3
- VectorBuilder custom plasmid, inducible vectors for PIAS3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PIAS3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for PIAS3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer