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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PIAS3 Gene

protein-coding GIFtS: 62
GCID: GC01P145575

Protein Inhibitor Of Activated STAT, 3

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Protein Inhibitor Of Activated STAT, 3¹ ²		ZMIZ5²
Protein Inhibitor Of Activated STAT Protein 3² ³		E3 SUMO-Protein Ligase PIAS3²
MIZ-Type Containing 5¹		Zinc Finger, MIZ-Type Containing 5²
Zinc Finger¹		EC 6.3.2.-³

External Ids:	HGNC: 16861¹	Entrez Gene: 10401²	Ensembl: ENSG00000131788⁷	OMIM: 605987⁵	UniProtKB: Q9Y6X2³

Export aliases for PIAS3 gene to outside databases

Previous GC identifers: GC01P144096 GC01P142163 GC01P143302 GC01P143324 GC01P143065 GC01P144287 GC01P119540

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PIAS3 Gene:

This gene encodes a member of the PIAS (protein inhibitor of activated STAT (signal transducer and activator of

transcription)) family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like

modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It

directly binds to several transcription factors and either blocks or enhances their activity. Alternatively

spliced transcript variants of this gene have been identified, but the full-length nature of some of these

variants has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for PIAS3 Gene:

PIAS3 (protein inhibitor of activated STAT, 3) is a protein-coding gene. Diseases associated with PIAS3 include alcoholic hepatitis, and microphthalmia, and among its related super-pathways are Development Thrombopoetin signaling via JAK-STAT pathway and PEDF Induced Signaling. GO annotations related to this gene include protein C-terminus binding and nucleic acid binding. An important paralog of this gene is ZMIZ2.

UniProtKB/Swiss-Prot: PIAS3_HUMAN, Q9Y6X2

Function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between

UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation

in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in

regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth

Gene Wiki entry for PIAS3 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NT_167185.1 NC_018912.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PIAS3 gene promoter:
TBP MAZR HTF E47 GATA-1 GATA-2 YY1 TFIID
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PIAS3 promoter sequence

Search SABiosciences Chromatin IP Primers for PIAS3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIAS3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.1 HGNC cytogenetic band: 1q21

PIAS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIAS3 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P145575: view genomic region (about GC identifiers)

Start:	145,575,233 bp from pter	End:	145,586,546 bp from pter
Size:	11,314 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PIAS3_HUMAN, Q9Y6X2 (See protein sequence)

Recommended Name: E3 SUMO-protein ligase PIAS3

Size: 628 amino acids; 68017 Da

Subunit: Monomer (By similarity). Binds SUMO1 and UBE2I. Interacts with BCL11A, HMGA2, IRF1, MITF and NCOA2.

Interacts with STAT5; the interaction occurs on stimulation by PRL. Interacts with GFI1; the interaction relieves

the inhibitory effect of PIAS3 on STAT3-mediated transcriptional activity (By similarity). Interacts with AR,

PLAG1 and ZFHX3. Interacts with STAT3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the

DNA binding activity of STAT3

Subcellular location: Cytoplasm. Nucleus. Note=Mainly cytoplasmic but shuttles between the nucleus and cytoplasm.

Transported to the nucleus on interaction with phosphorylated STAT3. Colocalizes with GFI1 in nuclear dots (By

similarity)

Sequence caution: Sequence=BAA78533.1; Type=Erroneous initiation;

Secondary accessions: Q9UFI3

Explore the universe of human proteins at neXtProt for PIAS3: NX_Q9Y6X2

Explore proteomics data for PIAS3 at MOPED

Post-translational modifications:

UniProtKB: Sumoylated (By similarity)

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9Y6X2

PIAS3 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_006090.2

ENSEMBL proteins:

ENSP00000376766 ENSP00000476245 ENSP00000376765 ENSP00000358304 ENSP00000358305

Human Recombinant Protein Products for PIAS3:

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	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for PIAS3

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0030425	dendrite	IEA	--
GO:0045202	synapse	IEA	--

PIAS3 for ontologies About GeneDecksing

PIAS3 Antibody Products:

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Assay Products for PIAS3:

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	Cloud-Clone Corp. ELISAs for PIAS3 Cloud-Clone Corp. CLIAs for PIAS3

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

ZMIZ: Zinc fingers, MIZ-type

4 InterPro protein domains:

IPR027226 PIAS3

IPR004181 Znf_MIZ

IPR003034 SAP_dom

IPR023321 PINIT

Graphical View of Domain Structure for InterPro Entry Q9Y6X2

ProtoNet protein and cluster: Q9Y6X2

2 Blocks protein domains:

IPB003034 DNA-binding SAP

IPB004181 Zn-finger

UniProtKB/Swiss-Prot: PIAS3_HUMAN, Q9Y6X2

Domain: The PINIT domain of PIAS3 is required for STAT3-PIAS3 interaction and for transloaction to the nucleus

Domain: The LXXLL motif is a transcriptional coregulator signature

Similarity: Belongs to the PIAS family

Similarity: Contains 1 PINIT domain

Similarity: Contains 1 SAP domain

Similarity: Contains 1 SP-RING-type zinc finger

PIAS3 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PIAS3_HUMAN, Q9Y6X2

Function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between

UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation

in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in

regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth

Induction: By dihydrotestosterone (DHT) in prostate cancer cells

Enzyme Number (IUBMB): EC 6.3.2.-¹

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0005515	protein binding	IPI	11060035
GO:0008022	protein C-terminus binding	IPI	14715251
GO:0008270	zinc ion binding	IEA	--
GO:0015459	potassium channel regulator activity	IEA	--

PIAS3 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for PIAS3

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PIAS3

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PIAS3

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PIAS3

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIAS3
		8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate PIAS3 (see all 41):
		hsa-miR-548j hsa-miR-3142 hsa-miR-9 hsa-miR-298 hsa-miR-3613-3p hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-4309

		SwitchGear 3'UTR luciferase reporter plasmid: PIAS3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for PIAS3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIAS3

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for PIAS3
			Sirion Biotech Customized adenovirus for overexpression of PIAS3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for PIAS3 (see all 10) OriGene ORF clones in mouse, rat for PIAS3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PIAS3 (NM_006099)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIAS3
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PIAS3
		Search LifeMap BioReagents cell lines for PIAS3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIAS3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for PIAS3 About (see all 15)

See pathways by source

SuperPath

Contained pathways About

Development Thrombopoetin signaling via JAK-STAT pathway

Development Thrombopoetin signaling via JAK-STAT pathway

0.32

Jak/Stat Pathway

0.32

PEDF Induced Signaling

IL-6 Pathway

0.61

TGF-Beta Pathway

JAK-STAT Pathway

0.57

Development Leptin signaling via JAK/STAT and MAPK cascades

Development Leptin signaling via JAK/STAT and MAPK cascades

1.00

Development Prolactin receptor signaling

Prolactin Signaling Pathway

0.39

Pathways by source See SuperPaths
Show all pathways

2 EMD Millipore Pathways for PIAS3

	Development Leptin signaling via JAK/STAT and MAPK cascades
	Development Thrombopoetin signaling via JAK-STAT pathway

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PIAS3

	JAK-STAT Pathway
	IL-6 Pathway

1 Cell Signaling Technology (CST) Pathway for PIAS3

Jak/Stat Pathway

2 GeneGo (Thomson Reuters) Pathways for PIAS3

	Development Leptin signaling via JAK/STAT and MAPK cascades
	Development Thrombopoetin signaling via JAK-STAT pathway

5/9 BioSystems Pathways for PIAS3 (see all 9)

	Oncostatin M Signaling Pathway
	Androgen receptor signaling pathway
	TNF-alpha/NF-kB Signaling Pathway
	Prolactin Signaling Pathway
	Interleukin-11 Signaling Pathway

2 Kegg Pathways (Kegg details for PIAS3):

	Ubiquitin mediated proteolysis
	Jak-STAT signaling pathway

UniProtKB/Swiss-Prot: PIAS3_HUMAN, Q9Y6X2

Pathway: Protein modification; protein sumoylation

PIAS3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PIAS3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/82 Interacting proteins for PIAS3 (Q9Y6X2^{2, 3} ENSP00000376765⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 82)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MBD1	Q9UIS9²^,³, ENSP00000269468⁴	MINT-3382939 MINT-3382965 MINT-3382869 I2D: score=1 STRING: ENSP00000269468
C19orf60	Q96EN9²^,³, ENSP00000351422⁴	MINT-8266106 I2D: score=2 STRING: ENSP00000351422
PSMC1	P62191²^,³, ENSP00000261303⁴	MINT-8266128 I2D: score=2 STRING: ENSP00000261303
ATF7IP	Q6VMQ6²^,³	MINT-61884 I2D: score=3
PRPF40A	O75400²^,³	MINT-61845 I2D: score=3

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0009725	response to hormone stimulus	IEA	--
GO:0010628	positive regulation of gene expression	IEA	--
GO:0016925	protein sumoylation	ISS	--

PIAS3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PIAS3

Search CenterWatch for drugs/clinical trials and news about PIAS3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PIAS3 gene:

NM_006099.3

Unigene Cluster for PIAS3:

Protein inhibitor of activated STAT, 3

Hs.435761 [show with all ESTs]

Unigene Representative Sequence: BC030556

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000393046 ENST00000463514 ENST00000393045(uc001eoc.1) ENST00000369298

ENST00000484423 ENST00000498436 ENST00000475261(uc001eod.1) ENST00000472114

ENST00000369299(uc010oyy.1)

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIAS3
		8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate PIAS3 (see all 41):
		hsa-miR-548j hsa-miR-3142 hsa-miR-9 hsa-miR-298 hsa-miR-3613-3p hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-4309

		SwitchGear 3'UTR luciferase reporter plasmid: PIAS3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		OriGene clones in human, mouse for PIAS3 (see all 10) OriGene ORF clones in mouse, rat for PIAS3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PIAS3 (NM_006099)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIAS3
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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PIAS3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIAS3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIAS3

Additional mRNA sequence:

AB021868.1 AK027557.1 AK294231.1 AK304039.1 AL122061.1 BC001154.1 BC030556.1 BT007036.1

CR457090.1

12 DOTS entries:

DT.444950 DT.95297810 DT.95073200 DT.95072139 DT.86857437 DT.121360682 DT.95073199 DT.95239075

DT.121360641 DT.121360655 DT.95073202 DT.99941193

24/208 AceView cDNA sequences (see all 208):

AU118455 AU279846 CB156534 BQ436701 AL582931 CA396111 AA375243 BM701760

BP377967 BI823858 CA489770 BM715935 BQ921259 BU508963 BM452958 BQ921265

BU178124 BU183507 BP366023 BP365437 CB158728 AW297008 NM_006099 CR590421

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for PIAS3 (see all 13) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	·	5d	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b	·	13c	^	14	^
SP1:																			-		-		-										-				-
SP2:																																	-				-												-
SP3:																																																	-
SP4:					-		-		-		-		-						-		-		-
SP5:									-		-		-						-		-		-

ExUns:	15a	·	15b	^	16a	·	16b	·	16c	^	17a	·	17b
SP1:	-						-		-
SP2:
SP3:	-						-		-
SP4:
SP5:

ECgene alternative splicing isoforms for PIAS3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PIAS3 expression in normal human tissues (normalized intensities) PIAS3 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCCCTGTAGT

About this image

PIAS3 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/7 selected tissues (see all 7) fully expand


Brain (Nervous System) fully expand to see all 4 entries
Cerebral Cortex
Olfactory Bulb

Eye (Sensory Organs) fully expand to see all 2 entries
Rod Precursor Cells Outer Nuclear Layer

Breast (Uncategorized)
breast epithelium

Limb (Muscoskeletal System)
Limb Bud Mesenchyme Cells Limb Bud

Mesoderm (Gastrulation Derivatives)
Limb Bud Mesenchyme Cells Limb Bud

See PIAS3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PIAS3

SOURCE GeneReport for Unigene cluster: Hs.435761

UniProtKB/Swiss-Prot: PIAS3_HUMAN, Q9Y6X2

Tissue specificity: Isoform 1 is expressed in most tissues except thymus and small intestine. Isoform 3 is

expressed only in brain, heart, thymus, muscle, lung, testis, lactating breast and embryonic stem cells

SABiosciences Custom PCR Arrays for PIAS3

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PIAS3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIAS3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIAS3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIAS3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIAS3 gene from 6/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pias3^{1 , 5}	protein inhibitor of activated STAT 3^{1, 5}	90.39(n)¹ 96.97(a)¹		3 (41.95 cM)⁵ 229615¹ NM_001165949.1¹ NP_001159421.1¹ 96696384⁵
chicken (Gallus gallus)	Aves	PIAS3⁶	protein inhibitor of activated STAT, 3	60(a)	1 ↔ 1	25(645944-647516)
lizard (Anolis carolinensis)	Reptilia	PIAS3⁶	Uncharacterized protein	65(a)	1 ↔ 1	AAWZ02037198(80-14535)
fruit fly (Drosophila melanogaster)	Insecta	Su(var)2-10³	chromosome condensation DNA binding	44(a)		2 45A8 --
worm (Caenorhabditis elegans)	Secernentea	gei-17³	--	36(a) (best of 3)		I(9109589-9115598) --
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	NFI1⁶ SIZ1⁶	SUMO E3 ligase, catalyzes the covalent attachment ... SUMO/Smt3 ligase that promotes the attachment of s...	11(a) 10(a)	many ↔ many many ↔ many	XV(628360-630540) IV(1289406-1292120)

ENSEMBL Gene Tree for PIAS3 (if available)
TreeFam Gene Tree for PIAS3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PIAS3 gene

ZMIZ2² PIAS1² PIAS2² ZMIZ1² PIAS4²

5 SIMAP similar genes for PIAS3 using alignment to 5 protein entries: PIAS3_HUMAN (see all proteins):

DKFZp727A051 PIAS1 PIAS2 DKFZp434O0617 PIAS4

PIAS3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114720026^1,2	C,F	--	145574047(+)	`GTTCAA/GCTGGC`	1	--	us2k¹		1		NA	120
rs140181984^1,2		--	145574069(+)	`TTGGCC/TTGGGT`	1	--	us2k¹		0	--	--	--	--
rs145378206^1,2		--	145574121(+)	`TAAAAA/GGATTT`	1	--	us2k¹		0	--	--	--	--
rs7549713^1,2	C	--	145574233(+)	`AGCACC/TTAATG`	1	--	us2k¹		0	--	--	--	--
rs35860513^1,2	C	--	145574275(+)	`CAAAT-/ATGCAG`	1	--	us2k¹		2		NA	4
rs145171790^1,2		--	145574284(+)	`AGCCAA/GCTATA`	1	--	us2k¹		0	--	--	--	--
rs72995948^1,2	C,F	--	145574318(+)	`GTAGTG/ACGGGT`	1	--	us2k¹		2		WA	120
rs149130093^1,2		--	145574400(+)	`GGCCAA/GGGTGA`	1	--	us2k¹		0	--	--	--	--
rs142357578^1,2		--	145574561(+)	`ACCCGC/GGGGGC`	1	--	us2k¹		0	--	--	--	--
rs75248808^1,2	C	--	145574636(+)	`CCCCCA/CCCAAA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PIAS3 (145575233 - 145586546 bp)

Structural Variations
Database of Genomic Variants (DGV) 8 variations for PIAS3: About this table

Variant ID	Type	Subtype	PubMed ID
dgv15n16	CNV	Deletion	17901297
dgv46e201	CNV	Deletion	23290073
esv2422428	CNV	Duplication	17116639
nsv872232	CNV	Gain	21882294
dgv347n71	CNV	Gain	21882294
nsv831381	CNV	Gain	17160897
nsv831370	CNV	Gain	17160897
nsv7181	OTHER	Inversion	18451855

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605987 OMIM disorders: --

12 diseases for PIAS3: About MalaCards

alcoholic hepatitis microphthalmia multiple myeloma alcoholism

hepatitis c myeloma prostatitis hepatitis

prostate cancer lung cancer endotheliitis breast cancer

1 disease from the University of Copenhagen DISEASES database for PIAS3:

Microphthalmia

PIAS3 for disorders About GeneDecksing

1 Novoseek inferred disease relationship for PIAS3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer	11.9	2	15138572 (1), 11071847 (1)

Export disorders for PIAS3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PIAS3 gene, integrated from 9 sources (see all 78):
(articles sorted by number of sources associating them with PIAS3)

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Isolation and chromosomal assignment of a human gene encoding protein inhibitor of activated STAT3 (PIAS3). (PubMed id 10319586)^{1, 2, 3} Ueki N.... Muramatsu M.-A. (1999)
Specific inhibition of Stat3 signal transduction by PIAS3. (PubMed id 9388184)^{1, 2, 9} Chung C.D.... Shuai K. (1997)
Protein inhibitor of activated STAT3 regulates androgen receptor signaling in prostate carcinoma cells. (PubMed id 11071847)^{1, 2, 9} Junicho A.... Muraguchi A. (2000)
ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3. (PubMed id 14715251)^{1, 2} Nojiri S.... Ito M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3. (PubMed id 11060035)^{1, 2} Roedel B.... Moeroey T. (2000)
Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3). (PubMed id 14691252)^{1, 9} Long J....Liu F. (2004)
The association and nuclear translocation of the PIAS 3-STAT3 complex is ligand and time dependent. (PubMed id 19903771)^{1, 9} Dabir S....Dowlati A. (2009)
Identifying a common molecular mechanism for inhibition of MITF and STAT3 by PIAS3. (PubMed id 16368885)^{1, 9} Levy C....Razin E. (2006)
Differential PIAS3 expression in human malignancy. (PubMed id 15138572)^{1, 9} Wang L. and Banerjee S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10401	HGNC: 16861	AceView: PIAS3	Ensembl:ENSG00000131788	euGenes: HUgn10401
ECgene: PIAS3	Kegg: 10401	H-InvDB: PIAS3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PIAS3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PIAS3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PIAS3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PIAS3 gene:
Search GeneIP for patents involving PIAS3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Protein Inhibitor Of Activated STAT, 3

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Protein Inhibitor Of Activated STAT, 3

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