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Aliases for PIAS3 Gene

Aliases for PIAS3 Gene

  • Protein Inhibitor Of Activated STAT, 3 2 3
  • Protein Inhibitor Of Activated STAT Protein 3 3 4
  • Zinc Finger, MIZ-Type Containing 5 3
  • E3 SUMO-Protein Ligase PIAS3 3
  • MIZ-Type Containing 5 2
  • Zinc Finger 2
  • EC 6.3.2.- 4
  • ZMIZ5 3

External Ids for PIAS3 Gene

Summaries for PIAS3 Gene

Entrez Gene Summary for PIAS3 Gene

  • This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PIAS3 Gene

PIAS3 (Protein Inhibitor Of Activated STAT, 3) is a Protein Coding gene. Among its related pathways are TGF-Beta Pathway and IL6-mediated signaling events. GO annotations related to this gene include nucleic acid binding and protein C-terminus binding. An important paralog of this gene is ZMIZ1.

UniProtKB/Swiss-Prot for PIAS3 Gene

  • Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.

Gene Wiki entry for PIAS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIAS3 Gene

Genomics for PIAS3 Gene

Genomic Location for PIAS3 Gene

Start:
145,848,522 bp from pter
End:
145,859,836 bp from pter
Size:
11,315 bases
Orientation:
Minus strand

Genomic View for PIAS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIAS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIAS3 Gene

Regulatory Elements for PIAS3 Gene

Proteins for PIAS3 Gene

  • Protein details for PIAS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6X2-PIAS3_HUMAN
    Recommended name:
    E3 SUMO-protein ligase PIAS3
    Protein Accession:
    Q9Y6X2
    Secondary Accessions:
    • Q9UFI3

    Protein attributes for PIAS3 Gene

    Size:
    628 amino acids
    Molecular mass:
    68017 Da
    Quaternary structure:
    • Monomer (By similarity). Binds SUMO1 and UBE2I. Interacts with BCL11A, HMGA2, IRF1, MITF and NCOA2. Interacts with STAT5; the interaction occurs on stimulation by PRL. Interacts with GFI1; the interaction relieves the inhibitory effect of PIAS3 on STAT3-mediated transcriptional activity (By similarity). Interacts with AR, PLAG1 and ZFHX3. Interacts with STAT3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3. Interacts with MTA1.
    SequenceCaution:
    • Sequence=BAA78533.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PIAS3 Gene

neXtProt entry for PIAS3 Gene

Proteomics data for PIAS3 Gene at MOPED

Post-translational modifications for PIAS3 Gene

Other Protein References for PIAS3 Gene

No data available for DME Specific Peptides for PIAS3 Gene

Domains for PIAS3 Gene

Gene Families for PIAS3 Gene

HGNC:
  • ZMIZ :Zinc fingers, MIZ-type

Protein Domains for PIAS3 Gene

UniProtKB/Swiss-Prot:

PIAS3_HUMAN
Domain:
  • The PINIT domain of PIAS3 is required for STAT3-PIAS3 interaction and for transloaction to the nucleus:
    • Q9Y6X2
  • The LXXLL motif is a transcriptional coregulator signature:
    • Q9Y6X2
  • Contains 1 PINIT domain.:
    • Q9Y6X2
  • Contains 1 SAP domain.:
    • Q9Y6X2
Family:
  • Belongs to the PIAS family.:
    • Q9Y6X2
Similarity:
  • Contains 1 SP-RING-type zinc finger.:
    • Q9Y6X2
genes like me logo Genes that share domains with PIAS3: view

Function for PIAS3 Gene

Molecular function for PIAS3 Gene

UniProtKB/Swiss-Prot Function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.
UniProtKB/Swiss-Prot Induction: By dihydrotestosterone (DHT) in prostate cancer cells.

Enzyme Numbers (IUBMB) for PIAS3 Gene

Gene Ontology (GO) - Molecular Function for PIAS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 11060035
GO:0008022 protein C-terminus binding IPI 14715251
GO:0008270 zinc ion binding IEA --
GO:0015459 potassium channel regulator activity IEA --
genes like me logo Genes that share ontologies with PIAS3: view

miRNA for PIAS3 Gene

miRTarBase miRNAs that target PIAS3

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PIAS3 Gene

Localization for PIAS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIAS3 Gene

Cytoplasm. Nucleus. Note=Mainly cytoplasmic but shuttles between the nucleus and cytoplasm. Transported to the nucleus on interaction with phosphorylated STAT3. Colocalizes with GFI1 in nuclear dots (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIAS3 Gene COMPARTMENTS Subcellular localization image for PIAS3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for PIAS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0030425 dendrite IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with PIAS3: view

Pathways for PIAS3 Gene

genes like me logo Genes that share pathways with PIAS3: view

Pathways by source for PIAS3 Gene

UniProtKB/Swiss-Prot Q9Y6X2-PIAS3_HUMAN

  • Pathway: Protein modification; protein sumoylation

Gene Ontology (GO) - Biological Process for PIAS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008152 metabolic process --
GO:0009725 response to hormone IEA --
GO:0010628 positive regulation of gene expression IEA --
genes like me logo Genes that share ontologies with PIAS3: view

Transcripts for PIAS3 Gene

Unigene Clusters for PIAS3 Gene

Protein inhibitor of activated STAT, 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIAS3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^
SP1: - - - - -
SP2: - - -
SP3: -
SP4: - - - - - - - -
SP5: - - - - - -
SP6:
SP7:
SP8: - - - -
SP9:
SP10:
SP11: - - -
SP12: - -
SP13: -

ExUns: 15a · 15b ^ 16a · 16b · 16c ^ 17a · 17b
SP1: - - -
SP2:
SP3: - - -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for PIAS3 Gene

GeneLoc Exon Structure for
PIAS3
ECgene alternative splicing isoforms for
PIAS3

Expression for PIAS3 Gene

mRNA expression in normal human tissues for PIAS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PIAS3 Gene

SOURCE GeneReport for Unigene cluster for PIAS3 Gene Hs.435761

mRNA Expression by UniProt/SwissProt for PIAS3 Gene

Q9Y6X2-PIAS3_HUMAN
Tissue specificity: Isoform 1 is expressed in most tissues except thymus and small intestine. Isoform 3 is expressed only in brain, heart, thymus, muscle, lung, testis, lactating breast and embryonic stem cells.
genes like me logo Genes that share expressions with PIAS3: view

Orthologs for PIAS3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIAS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIAS3 36
  • 95.59 (n)
  • 94.9 (a)
PIAS3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PIAS3 36
  • 93.31 (n)
  • 98.09 (a)
PIAS3 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIAS3 36
  • 92.78 (n)
  • 97.29 (a)
PIAS3 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pias3 36
  • 90.39 (n)
  • 96.97 (a)
Pias3 16
Pias3 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIAS3 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 15 (a)
OneToMany
-- 37
  • 38 (a)
OneToMany
-- 37
  • 27 (a)
OneToMany
-- 37
  • 20 (a)
OneToMany
-- 37
  • 22 (a)
OneToMany
-- 37
  • 32 (a)
OneToMany
-- 37
  • 23 (a)
OneToMany
-- 37
  • 43 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pias3 36
  • 90.23 (n)
  • 96.66 (a)
chicken
(Gallus gallus)
Aves PIAS3 37
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIAS3 37
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pias3 36
  • 69.57 (n)
  • 74.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta Su(var)2-10 37
  • 34 (a)
OneToMany
Su(var)2-10 38
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea gei-17 37
  • 20 (a)
OneToMany
gei-17 38
  • 36 (a)
W10D5.3a 38
  • 35 (a)
W10D5.3d 38
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NFI1 37
  • 14 (a)
ManyToMany
SIZ1 37
  • 11 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2754 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
OneToMany
Species with no ortholog for PIAS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PIAS3 Gene

ENSEMBL:
Gene Tree for PIAS3 (if available)
TreeFam:
Gene Tree for PIAS3 (if available)

Paralogs for PIAS3 Gene

Paralogs for PIAS3 Gene

Selected SIMAP similar genes for PIAS3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PIAS3: view

Variants for PIAS3 Gene

Sequence variations from dbSNP and Humsavar for PIAS3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4128488 -- 145,849,751(+) AATCC(C/T)GACTT intron-variant
rs6672707 -- 145,859,829(-) TAGGC(C/G)GGGCG upstream-variant-2KB
rs7549713 -- 145,860,835(-) AGCAC(C/T)TAATG upstream-variant-2KB
rs9726019 -- 145,849,934(-) CGCCC(A/C)CAAAG intron-variant
rs10910827 -- 145,853,560(-) CCTAC(A/G)TGGAC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for PIAS3 Gene

Variant ID Type Subtype PubMed ID
nsv7181 OTHER Inversion 18451855
dgv15n16 CNV Deletion 17901297
dgv46e201 CNV Deletion 23290073
esv2422428 CNV Duplication 17116639
dgv347n71 CNV Gain 21882294
nsv831370 CNV Gain 17160897
nsv831381 CNV Gain 17160897
nsv872232 CNV Gain 21882294

Relevant External Links for PIAS3 Gene

HapMap Linkage Disequilibrium report
PIAS3

Disorders for PIAS3 Gene

(1) University of Copenhagen DISEASES for PIAS3 Gene

(1) Novoseek inferred disease relationships for PIAS3 Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 11.9 2
genes like me logo Genes that share disorders with PIAS3: view

No data available for UniProtKB/Swiss-Prot for PIAS3 Gene

Publications for PIAS3 Gene

  1. Protein inhibitor of activated STAT3 regulates androgen receptor signaling in prostate carcinoma cells. (PMID: 11071847) Junicho A. … Muraguchi A. (Biochem. Biophys. Res. Commun. 2000) 3 4 23
  2. Isolation and chromosomal assignment of a human gene encoding protein inhibitor of activated STAT3 (PIAS3). (PMID: 10319586) Ueki N. … Muramatsu M.-A. (J. Hum. Genet. 1999) 2 3 4
  3. Specific inhibition of Stat3 signal transduction by PIAS3. (PMID: 9388184) Chung C.D. … Shuai K. (Science 1997) 3 4 23
  4. Identifying a common molecular mechanism for inhibition of MITF and STAT3 by PIAS3. (PMID: 16368885) Levy C. … Razin E. (Blood 2006) 3 23
  5. ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3. (PMID: 14715251) Nojiri S. … Ito M. (Biochem. Biophys. Res. Commun. 2004) 3 4

Products for PIAS3 Gene

Sources for PIAS3 Gene

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